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https://www.readbyqxmd.com/read/28207200/a-pet-guided-framework-supports-a-multiple-arterial-input-functions-approach-in-dsc-mri-in-acute-stroke
#1
Michelle Livne, Vince I Madai, Peter Brunecker, Olivier Zaro-Weber, Walter Moeller-Hartmann, Wolf-Dieter Heiss, Kim Mouridsen, Jan Sobesky
BACKGROUND AND PURPOSE: In acute stroke, arterial-input-function (AIF) determination is essential for obtaining perfusion estimates with dynamic susceptibility-weighted contrast-enhanced magnetic resonance imaging (DSC-MRI). Standard DSC-MRI postprocessing applies single AIF selection, ie, global AIF. Physiological considerations, however, suggest that a multiple AIFs selection method would improve perfusion estimates to detect penumbral flow. In this study, we developed a framework based on comparable DSC-MRI and positron emission tomography (PET) images to compare the two AIF selection approaches and assess their performance in penumbral flow detection in acute stroke...
February 16, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28153658/first-trimester-alcohol-exposure-alters-placental-perfusion-and-fetal-oxygen-availability-affecting-fetal-growth-and-development-in-a-non-human-primate-model
#2
Jamie O Lo, Matthias C Schabel, Victoria H J Roberts, Xiaojie Wang, Katherine S Lewandowski, Kathleen A Grant, Antonio E Frias, Christopher D Kroenke
BACKGROUND: Prenatal alcohol exposure leads to impaired fetal growth, brain development, and stillbirth. Placental impairment likely contributes to these adverse outcomes, but the mechanisms and specific vasoactive effects of alcohol that links altered placental function to impaired fetal development remain areas of active research. OBJECTIVE: Recently, we developed magnetic resonance imaging techniques in nonhuman primates to characterize placental blood oxygenation through measurements of T2* and perfusion using dynamic contrast-enhanced magnetic resonance imaging...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28152250/intravoxel-incoherent-motion-mri-in-the-brain-impact-of-the-fitting-model-on-perfusion-fraction-and-lesion-differentiability
#3
Vera C Keil, Burkhard Mädler, Gerrit H Gielen, Bogdan Pintea, Kanishka Hiththetiya, Alisa R Gaspranova, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
PURPOSE: To investigate the effect of the choice of the curve-fitting model on the perfusion fraction (fIVIM ) with regard to tissue type characterization, correlation with microvascular anatomy, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters. Several curve-fitting models coexist in intravoxel incoherent motion (IVIM) MRI to derive the (fIVIM ). MATERIALS AND METHODS: In all, 29 patients with brain lesions (12 gliomas, 11 meningiomas, three metastases, two gliotic scars, one multiple sclerosis) underwent IVIM-MRI (32 b-values, 0 to 2000 s/mm(2) ) at 3T...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28149758/defining-the-endpoints-how-to-measure-the-efficacy-of-drugs-that-are-active-against-central-nervous-system-metastases
#4
REVIEW
Alessandra Fabi, Antonello Vidiri
Brain metastases (BMs) are the most common cause of malignant central nervous system (CNS) tumors in adults. In the recent past, patients with BMs were excluded from clinical trials, but now, with the advent of new biological and immunological drugs, their inclusion is more common. In the last era response and progression criteria used across clinical trials have defined the importance to consider not only measurement changes of brain lesions but also the modification of parameters related to the metastases such as metabolism of tissue and its pathological features...
December 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28137548/intraoperative-mr-imaging-of-cerebral-oxygen-metabolism-during-resection-of-brain-lesions
#5
REVIEW
Andreas Stadlbauer, Andreas Merkel, Max Zimmermann, Björn Sommer, Michael Buchfelder, Anke Meyer-Bäse, Karl Rössler
OBJECTIVE: Tissue oxygen tension is an important parameter for brain tissue viability and its non-invasive intraoperative monitoring in the whole brain is of highly clinical relevance. The purpose of this study was the introduction of a multiparametric quantitative blood oxygenation dependent (qBOLD) MRI approach for intraoperative examination of oxygen metabolism during the resection of brain lesions. METHODS: Sixteen patients suffering from brain lesions were intraoperatively examined twice (before craniotomy and after gross-total resection) using the qBOLD technique and a 1...
January 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28133747/on-the-potential-for-rf-heating-in-mri-to-affect-metabolic-rates-and-18-fdg-signal-in-pet-mr-simulations-of-long-duration-maximum-normal-mode-heating
#6
Giuseppe Carluccio, Yu-Shin Ding, Jean Logan, Christopher M Collins
PURPOSE: To examine the possibility that MR-induced RF power deposition (SAR) and the resulting effects on temperature-dependent metabolic rates or perfusion rates might affect observed 18FDG signal in PET/MR. METHODS: Using numerical simulations of the SAR, consequent temperature increase, effect on rates of metabolism or perfusion, and [18FDG] throughout the body, we simulated the potential effect of maximum-allowable whole-body SAR for the entire duration of an hour-long PET/MR scan on observed PET signal for two different 18FDG injection times: one hour before onset of imaging and concurrent with the beginning of imaging...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28101340/pseudo-continuous-arterial-spin-labeling-imaging-of-cerebral-blood-perfusion-asymmetry-in-drug-na%C3%A3-ve-patients-with-first-episode-major-depression
#7
Guangdong Chen, Haiman Bian, Deguo Jiang, Mingwei Cui, Shengzhang Ji, Mei Liu, Xu Lang, Chuanjun Zhuo
Many previous studies have reported that regional cerebral blood flow (rCBF) aberrations may be one of the pathological characteristics of depression and rCBF has demonstrated a certain degree of asymmetry. However, studies investigating the cerebral blood perfusion asymmetry changes of drug-naïve patients experiencing their first episode of major depression using pseudo-continuous arterial spin labeling (pCASL) are rare. Ten drug-naïve patients experiencing their first major depression episode and 15 healthy volunteers were enrolled in the current study...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28096729/advanced-mri-for-pediatric-brain-tumors-with-emphasis-on-clinical-benefits
#8
REVIEW
Hyun Woo Goo, Young-Shin Ra
Conventional anatomic brain MRI is often limited in evaluating pediatric brain tumors, the most common solid tumors and a leading cause of death in children. Advanced brain MRI techniques have great potential to improve diagnostic performance in children with brain tumors and overcome diagnostic pitfalls resulting from diverse tumor pathologies as well as nonspecific or overlapped imaging findings. Advanced MRI techniques used for evaluating pediatric brain tumors include diffusion-weighted imaging, diffusion tensor imaging, functional MRI, perfusion imaging, spectroscopy, susceptibility-weighted imaging, and chemical exchange saturation transfer imaging...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28095387/mri-of-cerebellar-infarction
#9
Laurens J L De Cocker, Karl-Olof Lövblad, Jeroen Hendrikse
BACKGROUND: MRI is the imaging modality of choice for diagnosing brain infarction. Because of few or atypical clinical symptoms and a relatively low sensitivity of CT scans, many cerebellar infarctions may be detected only with MRI. With adequate recognition of cerebellar infarction on MRI and prompt initiation or optimisation of preventive therapeutic measures, more dramatic strokes may be avoided in selected cases. SUMMARY: We first briefly review the clinical presentation of cerebellar infarctions, followed by a short refresher on cerebellar anatomy and pathophysiological mechanisms of cerebellar infarcts...
January 18, 2017: European Neurology
https://www.readbyqxmd.com/read/28091350/the-effects-of-flavanone-rich-citrus-juice-on-cognitive-function-and-cerebral-blood-flow-an-acute-randomised-placebo-controlled-cross-over-trial-in-healthy-young-adults
#10
Daniel J Lamport, Deepa Pal, Anna L Macready, Sofia Barbosa-Boucas, John M Fletcher, Claire M Williams, Jeremy P E Spencer, Laurie T Butler
A plausible mechanism underlying flavonoid-associated cognitive effects is increased cerebral blood flow (CBF). However, behavioural and CBF effects following flavanone-rich juice consumption have not been explored. The aim of this study was to investigate whether consumption of flavanone-rich juice is associated with acute cognitive benefits and increased regional CBF in healthy, young adults. An acute, single-blind, randomised, cross-over design was applied with two 500-ml drink conditions - high-flavanone (HF; 70·5 mg) drink and an energy-, and vitamin C- matched, zero-flavanone control...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/28090589/spiral-perfusion-imaging-with-consecutive-echoes-spice%C3%A2-for-the-simultaneous-mapping-of-dsc-and-dce-mri-parameters-in-brain-tumor-patients-theory-and-initial-feasibility
#11
Eric S Paulson, Douglas E Prah, Kathleen M Schmainda
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhibits combined T1, T2, and T2* shortening effects in tissue, and therefore, the results of both DCE- and DSC-MRI can be confounded by these opposing effects...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28070841/reproducibility-of-dynamic-contrast-enhanced-mri-and-dynamic-susceptibility-contrast-mri-in-the-study-of-brain-gliomas-a-comparison-of-data-obtained-using-different-commercial-software
#12
Gian Marco Conte, Antonella Castellano, Luisa Altabella, Antonella Iadanza, Marcello Cadioli, Andrea Falini, Nicoletta Anzalone
PURPOSE: Dynamic susceptibility contrast MRI (DSC) and dynamic contrast-enhanced MRI (DCE) are useful tools in the diagnosis and follow-up of brain gliomas; nevertheless, both techniques leave the open issue of data reproducibility. We evaluated the reproducibility of data obtained using two different commercial software for perfusion maps calculation and analysis, as one of the potential sources of variability can be the software itself. METHODS: DSC and DCE analyses from 20 patients with gliomas were tested for both the intrasoftware (as intraobserver and interobserver reproducibility) and the intersoftware reproducibility, as well as the impact of different postprocessing choices [vascular input function (VIF) selection and deconvolution algorithms] on the quantification of perfusion biomarkers plasma volume (Vp), volume transfer constant (K (trans)) and rCBV...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28046971/th-cd-206-01-expectation-maximization-algorithm-based-tissue-mixture-quantification-for-perfusion-mri
#13
H Han, Z Liang, L Li, L Xing
PURPOSE: To investigate the feasibility of estimating the tissue mixture perfusions and quantifying cerebral blood flow change in arterial spin labeled (ASL) perfusion MR images. METHODS: The proposed perfusion MR image analysis framework consists of 5 steps: (1) Inhomogeneity correction was performed on the T1- and T2-weighted images, which are available for each studied perfusion MR dataset. (2) We used the publicly available FSL toolbox to strip off the non-brain structures from the T1- and T2-weighted MR images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034995/effects-of-mri-protocol-parameters-preload-injection-dose-fractionation-strategies-and-leakage-correction-algorithms-on-the-fidelity-of-dynamic-susceptibility-contrast-mri-estimates-of-relative-cerebral-blood-volume-in-gliomas
#14
K Leu, J L Boxerman, B M Ellingson
BACKGROUND AND PURPOSE: DSC perfusion MR imaging assumes that the contrast agent remains intravascular; thus, disruptions in the blood-brain barrier common in brain tumors can lead to errors in the estimation of relative CBV. Acquisition strategies, including the choice of flip angle, TE, TR, and preload dose and incubation time, along with post hoc leakage-correction algorithms, have been proposed as means for combating these leakage effects. In the current study, we used DSC-MR imaging simulations to examine the influence of these various acquisition parameters and leakage-correction strategies on the faithful estimation of CBV...
December 29, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28030441/does-permissive-hypoxaemia-during-extracorporeal-membrane-oxygenation-cause-long-term-neurological-impairment-a-study-in-patients-with-h1n1-induced-severe-respiratory-failure
#15
Bernhard Holzgraefe, Christin Andersson, Håkan Kalzén, Viktor von Bahr, Mikael Mosskin, Elna-Marie Larsson, Kenneth Palmér, Björn Frenckner, Anders Larsson
BACKGROUND: The Extracorporeal Life Support Organisation accepts permissive hypoxaemia in adult patients during extracorporeal membrane oxygenation (ECMO). The neurological long-term outcome of this approach has not yet been studied. OBJECTIVES: We investigated the prevalence of brain lesions and cognitive dysfunction in survivors from the Influenza A/H1N1 2009 pandemic treated with permissive hypoxaemia during ECMO for severe acute respiratory distress syndrome (ARDS)...
February 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28019027/robustness-of-spatio-temporal-regularization-in-perfusion-mri-deconvolution-an-application-to-acute-ischemic-stroke
#16
Mathilde Giacalone, Carole Frindel, Marc Robini, Frédéric Cervenansky, Emmanuel Grenier, David Rousseau
PURPOSE: The robustness of a recently introduced globally convergent deconvolution algorithm with temporal and edge-preserving spatial regularization for the deconvolution of dynamic susceptibility contrast perfusion magnetic resonance imaging is assessed in the context of ischemic stroke. THEORY AND METHODS: Ischemic tissues are not randomly distributed in the brain but form a spatially organized entity. The addition of a spatial regularization term allows to take into account this spatial organization contrarily to the sole temporal regularization approach which processes each voxel independently...
December 26, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28018896/factors-influencing-neurodevelopment-after-cardiac-surgery-during-infancy
#17
REVIEW
Hedwig Hubertine Hövels-Gürich
Short- and long-term neurodevelopmental (ND) disabilities with negative impact on psychosocial and academic performance, quality of life, and independence in adulthood are known to be the most common sequelae for surviving children after surgery for congenital heart disease (CHD). This article reviews influences and risk factors for ND impairment. For a long time, the search for independent risk factors was focused on the perioperative period and modalities of cardiopulmonary bypass (CPB). CPB operations to ensure intraoperative vital organ perfusion and oxygen supply with or without circulatory arrest or regional cerebral perfusion bear specific risks...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28006726/perfusion-deconvolution-in-dsc-mri-with-dispersion-compliant-bases
#18
Marco Pizzolato, Timothé Boutelier, Rachid Deriche
Perfusion imaging of the brain via Dynamic Susceptibility Contrast MRI (DSC-MRI) allows tissue perfusion characterization by recovering the tissue impulse response function and scalar parameters such as the cerebral blood flow (CBF), blood volume (CBV), and mean transit time (MTT). However, the presence of bolus dispersion causes the data to reflect macrovascular properties, in addition to tissue perfusion. In this case, when performing deconvolution of the measured arterial and tissue concentration time-curves it is only possible to recover the effective, i...
December 6, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/28005983/alterations-of-the-blood-brain-barrier-and-regional-perfusion-in-tumor-development-mri-insights-from-a-rat-c6-glioma-model
#19
Monika Huhndorf, Amir Moussavi, Nadine Kramann, Olga Will, Kirsten Hattermann, Christine Stadelmann, Olav Jansen, Susann Boretius
OBJECTIVES: Angiogenesis and anti-angiogenetic medications play an important role in progression and therapy of glioblastoma. In this context, in vivo characterization of the blood-brain-barrier and tumor vascularization may be important for individual prognosis and therapy optimization. METHODS: We analyzed perfusion and capillary permeability of C6-gliomas in rats at different stages of tumor-growth by contrast enhanced MRI and dynamic susceptibility contrast (DSC) MRI at 7 Tesla...
2016: PloS One
https://www.readbyqxmd.com/read/27988320/heterogeneous-increases-of-regional-cerebral-blood-flow-during-preterm-brain-development-preliminary-assessment-with-pseudo-continuous-arterial-spin-labeled-perfusion-mri
#20
Minhui Ouyang, Peiying Liu, Tina Jeon, Lina Chalak, Roy Heyne, Nancy K Rollins, Daniel J Licht, John A Detre, Timothy P L Roberts, Hanzhang Lu, Hao Huang
The human brain develops rapidly during 32-45 postmenstrual weeks (PMW), a critical stage characterized by dramatic increases of metabolic demand. The increasing metabolic demand can be inferred through measurements of regional cerebral blood flow (CBF), which might be coupled to regional metabolism in preterm brains. Arterial spin labeled (ASL) perfusion MRI is one of the few viable approaches for imaging regional CBF of preterm brains, but must be optimized for the extremely slow blood velocity unique in preterm brains...
February 15, 2017: NeuroImage
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