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https://www.readbyqxmd.com/read/29342269/a-silent-epidemic-the-prevalence-incidence-and-persistence-of-mycoplasma-genitalium-among-young-asymptomatic-high-risk-women-in-the-united-states
#1
Arlene C Seña, Jeannette Y Lee, Jane Schwebke, Susan S Philip, Harold C Wiesenfeld, Anne M Rompalo, Robert L Cook, Marcia M Hobbs
Background: Mycoplasma genitalium (MG) is a sexually transmitted infection (STI) that can result in pelvic inflammatory disease and adverse pregnancy outcomes. We analyzed data collected from a prospective study of asymptomatic bacterial vaginosis (BV) to determine the natural history of MG. Methods: Women aged 15-25 years, with ≥2 STI risk factors and asymptomatic BV were recruited from 10 sites throughout the United States. Vaginal swabs were collected at enrollment, and by home-based testing every 2 months over 12 months...
January 12, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29335216/a-new-screened-microbial-consortium-oem2-for-lignocellulosic-biomass-deconstruction-and-chlorophenols-detoxification
#2
Jiajin Liang, Xiuxiu Fang, Yunqin Lin, Dehan Wang
Recalcitrance limits biomass application in biorefinery. It is even more so when toxic chlorophenols are present. In this study, we screened a microbial consortium, OEM2, for lignocellulose deconstruction and chlorophenols detoxification through a short-term and efficient screening process. Microbial consortium OEM2 had a good buffer capability in the cultivation process and exhibited a high xylanase activity, with over 85% hemicellulose degradation within 12 days. Throughout the treatment process, 41.5% rice straw decomposition on day 12 and around 75% chlorophenols (MCP, 2,4-DCP, 2,4,6-TCP) removal on day 9, were recorded...
January 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29333040/pharmacological-screening-of-trachyspermum-ammi-for-antihyperlipidemic-activity-in-triton-x-100-induced-hyperlipidemia-rat-model
#3
Uzma Saleem, Saba Riaz, Bashir Ahmad, Mohammad Saleem
Background: Mortality rate is increasing due to cardiovascular problems throughout the world. These cardiac problems are directly associated with dyslipidemia. Aim: The aim of this study was to evaluate the antihyperlipidemic effect of aqueous extract and methanol extract of Trachyspermum ammi at 1 g/kg, 3 g/kg, and 5 g/kg dose levels in rats. Materials and Methods: For this purpose, 45 male albino rats were used and randomly divided into nine equal groups (n = 5)...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29332863/lipid-parameters-are-independently-associated-with-cardio-ankle-vascular-index-cavi-in-healthy-japanese-subjects
#4
Daiji Nagayama, Yasuhiro Watanabe, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
AIM: To investigate the associations of conventional lipid parameters with arterial stiffness assessed by cardio-ankle vascular index (CAVI). METHODS: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1±12.5 years, body mass index (BMI) 22.9±3.4 kg/m2) who underwent health screening between 2004 and 2006 in Japan. RESULTS: Male subjects had significantly higher BMI, CAVI and triglycerides (TG), and lower high-density lipoprotein cholesterol (HDL-C) compared to female subjects...
January 12, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29302782/functional-results-following-high-tibial-osteotomy-a-review-of-the-literature
#5
REVIEW
Mark Webb, Varun Dewan, David Elson
INTRODUCTION: High tibial osteotomy (HTO) is an operation used to treat patients with medial compartment knee osteoarthritis. The United Kingdom Knee Osteotomy Registry (UKKOR) has been set up to gather contemporaneous data on HTO throughout the patient journey. UKKOR uses a variety of patient-reported outcome measures (PROMs) to gauge the surgical outcome. AIM: The aim of this review is to analyse the published literature that has used PROMs to assess the outcomes following HTO...
January 4, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29297315/utilizing-random-forest-qsar-models-with-optimized-parameters-for-target-identification-and-its-application-to-target-fishing-server
#6
Kyoungyeul Lee, Minho Lee, Dongsup Kim
BACKGROUND: The identification of target molecules is important for understanding the mechanism of "target deconvolution" in phenotypic screening and "polypharmacology" of drugs. Because conventional methods of identifying targets require time and cost, in-silico target identification has been considered an alternative solution. One of the well-known in-silico methods of identifying targets involves structure activity relationships (SARs). SARs have advantages such as low computational cost and high feasibility; however, the data dependency in the SAR approach causes imbalance of active data and ambiguity of inactive data throughout targets...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29289377/treatment-of-paraphilic-disorders-in-sexual-offenders-or-men-with-a-risk-of-sexual-offending-with-luteinizing-hormone-releasing-hormone-agonists-an-updated-systematic-review
#7
REVIEW
Daniel Turner, Peer Briken
BACKGROUND: Different pharmacologic agents are used in the treatment of paraphilic disorders in sexual offenders or men with a risk of sexual offending, with luteinizing hormone-releasing hormone (LHRH) agonists being the agents introduced more recently to treatment regimens. AIM: To summarize the relevant literature concerning LHRH agonist treatment of paraphilic disorders in sexual offenders and update the previously published systematic review by Briken et al (J Clin Psychiatry 2003;64:890-897)...
January 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29288544/metabarcoding-for-the-parallel-identification-of-several-hundred-predators-and-their-preys-application-to-bat-species-diet-analysis
#8
Maxime Galan, Jean-Baptiste Pons, Orianne Tournayre, Éric Pierre, Maxime Leuchtmann, Dominique Pontier, Nathalie Charbonnel
Assessing diet variability is of main importance to better understand the biology of bats and design conservation strategies. Although the advent of metabarcoding has facilitated such analyses, this approach does not come without challenges. Biases may occur throughout the whole experiment, from fieldwork to biostatistics, resulting in the detection of false negatives, false positives or low taxonomic resolution. We detail a rigorous metabarcoding approach based on a short COI minibarcode and two-step PCR protocol enabling the 'all at once' taxonomic identification of bats and their arthropod preys for several hundreds of samples...
December 30, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29287061/the-effects-of-interrupting-prolonged-sitting-with-intermittent-activity-on-appetite-sensations-and-subsequent-food-intake-in-preadolescent-children
#9
Tiwaloluwa A Ajibewa, Molly P O'Sullivan, Matthew R Nagy, Shannon S Block, Leah E Robinson, Natalie Colabianchi, Rebecca E Hasson
BACKGROUND: Short-term and long-term exposure to prolonged sitting is associated with excess food intake and weight gain in children. Interrupting prolonged sitting with low-intensity activity has been shown to not alter hunger, satiety, or food consumption in children, however it is unclear whether interrupting sitting with high-intensity activity will alter appetite regulation in children. PURPOSE: The purpose of this study was to examine the acute effects of interrupting prolonged sitting with intermittent activity performed at varying intensities on hunger, satiety, prospective food consumption (PFC), and food intake in preadolescent children...
2017: PloS One
https://www.readbyqxmd.com/read/29284343/evaluation-of-a-medication-intensity-screening-tool-used-in-malignant-hematology-and-bone-marrow-transplant-services-to-identify-patients-at-risk-for-medication-related-problems
#10
Mariana Lucena, Carolyn Bondarenka, Genevieve Luehrs Hayes, Andy Perez
Background In 2014, a screening tool was implemented at Medical University of South Carolina (MUSC) Health to identify patients who are at risk for medication-related events. Patients are classified as high-risk if they meet one of the following criteria: receiving anticoagulation therapy, taking more than 10 scheduled medications upon admission, or readmission within the past 30 days. The goal of this study was to determine risk criteria specific to the malignant hematology (MH) and bone marrow transplant (BMT) patients...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29275068/sucrose-octasulfate-dressing-versus-control-dressing-in-patients-with-neuroischaemic-diabetic-foot-ulcers-explorer-an-international-multicentre-double-blind-randomised-controlled-trial
#11
Michael Edmonds, José Luis Lázaro-Martínez, Jesus Manuel Alfayate-García, Jacques Martini, Jean-Michel Petit, Gerry Rayman, Ralf Lobmann, Luigi Uccioli, Anne Sauvadet, Serge Bohbot, Jean-Charles Kerihuel, Alberto Piaggesi
BACKGROUND: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. We aimed to assess the effect of a sucrose octasulfate dressing versus a control dressing on wound closure in patients with neuroischaemic diabetic foot ulcers...
December 20, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29273943/thyroid-disease-in-children-and-adolescents-with-pten-hamartoma-tumor-syndrome-phts
#12
Michaela Plamper, Felix Schreiner, Bettina Gohlke, Janina Kionke, Eckard Korsch, James Kirkpatrick, Mark Born, Stefan Aretz, Joachim Woelfle
Patients with PTEN hamartoma tumor syndrome (PHTS) are at increased risk of developing benign and malignant tumors, including thyroid carcinoma. Benign thyroid lesions and single cases of thyroid carcinoma have been reported in children with PHTS. We conducted a retrospective, single-centered study including children and adolescents with a molecularly proven diagnosis of PTEN. Our cohort consists of 16 patients, with a mean age at diagnosis PHTS of 5.7 years. Twelve of 16 cases exhibited thyroid abnormalities (75%)...
December 22, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29258505/malaria-prevalence-in-mangaluru-city-area-in-the-southwestern-coastal-region-of-india
#13
Kiran K Dayanand, Kishore Punnath, Valleesha Chandrashekar, Rajeshwara N Achur, Srinivas B Kakkilaya, Susanta K Ghosh, Suchetha Kumari, D Channe Gowda
BACKGROUND: Malaria is highly prevalent in many parts of India and the Indian subcontinent. Mangaluru, a city in the southwest coastal region of Karnataka state in India, and surrounding areas are malaria endemic with 10-12 annual parasite index. Despite high endemicity, to-date, very little has been reported on the epidemiology and burden of malaria in this area. METHODS: A cross-sectional surveillance of malaria cases was performed among 900 febrile symptomatic native people (long-time residents) and immigrant labourers (temporary residents) living in Mangaluru city area...
December 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29249913/new-strategies-to-improve-polypectomy-during-colonoscopy
#14
Michael B Wallace
In the United States, colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. The most effective strategy for prevention of CRC is to screen for and remove precancerous polyps. There are various ways to screen for CRC. In the United States, the most common method is colonoscopy. Polyps are classified primarily through pathology. Size is the primary risk factor for malignancy. In general, the bigger the polyp, the greater the risk for malignancy. There are 3 basic options for removal: standard polypectomy; advanced resection techniques, known as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD); and surgical removal...
October 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29246899/genetic-identification-of-separase-regulators-in-caenorhabditis-elegans
#15
Michael Melesse, Dillon E Sloan, Joseph T Benthal, Quincey Caylor, Krishen Gosine, Xiaofei Bai, Joshua N Bembenek
Separase is a highly conserved protease required for chromosome segregation. Although observations that separase also regulates membrane trafficking events have been made, it is still not clear how separase achieves this function. Here we present an extensive ENU mutagenesis suppressor screen aimed at identifying suppressors of sep-1(e2406), a temperature-sensitive maternal effect embryonic lethal separase mutant that primarily attenuates membrane trafficking rather than chromosome segregation. We screened nearly a million haploid genomes, and isolated sixty-eight suppressed lines...
December 15, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29242195/key-programme-science-lessons-from-an-hiv-prevention-learning-site-for-sex-workers-in-mombasa-kenya
#16
Leigh M McClarty, Parinita Bhattacharjee, Shajy Isac, Faran Emmanuel, Japheth Kioko, Margaret Njiraini, Peter Gichangi, Clifford Duncan Okoth, Janet Musimbi-Mbole, James F Blanchard, Stephen Moses, Helgar Muysyoki, Marissa L Becker
OBJECTIVES: In 2013, Kenya's National AIDS and STI Control Programme established a Learning Site (LS) in Mombasa County to support and strengthen capacity for HIV prevention programming within organisations working with sex workers. A defining feature of LS was the use of a Programme Science approach throughout its development and implementation. We provide an overview of the key components of LS, present findings from 23 months of programme monitoring data, and highlight key Programme Science lessons from its implementation and monitoring...
December 14, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29239901/prevention-of-hiv-1-transmission-through-breastfeeding-efficacy-and-safety-of-maternal-antiretroviral-therapy-versus-infant-nevirapine-prophylaxis-for-duration-of-breastfeeding-in-hiv-1-infected-women-with-high-cd4-cell-count-impaact-promise-a-randomized-open
#17
Patricia M Flynn, Taha E Taha, Mae Cababasay, Mary Glenn Fowler, Lynne M Mofenson, Maxensia Owor, Susan Fiscus, Lynda Stranix-Chibanda, Anna Coutsoudis, Devasena Gnanashanmugam, Nahida Chakhtoura, Katie McCarthy, Cornelius Mukuzunga, Bonus Makanani, Dhayendre Moodley, Teacler Nematadzira, Bangini Kusakara, Sandesh Patil, Tichaona Vhembo, Raziya Bobat, Blandina T Mmbaga, Maysseb Masenya, Mandisa Nyati, Gerhard Theron, Helen Mulenga, Kevin Butler, David E Shapiro
BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in sub-Saharan Africa and India. METHODS: A randomized, open label strategy trial was conducted in HIV-1-infected women with CD4 counts >350 cells/mm (or >country-specific ART threshold if higher) and their breastfeeding HIV-1-uninfected newborns...
December 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29228046/genome-wide-microarray-analysis-leads-to-identification-of-genes-in-response-to-herbicide-metribuzin-in-wheat-leaves
#18
Whitney Pilcher, Hana Zandkamiri, Kelly Arceneaux, Stephen Harrison, Niranjan Baisakh
Herbicides are an important component of weed management in wheat, particularly in the southeastern US where weeds actively compete with wheat throughout the winter for nutrients and reduce tillering and ultimately the yield of the crop. Some wheat varieties are sensitive to metribuzin, a low-cost non-selective herbicide, leading to leaf chlorosis, stand loss, and decreased yield. Knowledge of the genetics of herbicide tolerance in wheat is very limited and most new varieties have not been screened for metribuzin tolerance...
2017: PloS One
https://www.readbyqxmd.com/read/29227878/harm-reduction-based-and-peer-supported-hepatitis-c-treatment-for-people-who-inject-drugs-in-georgia
#19
Tamar Kikvidze, Niklas Luhmann, Elisabeth Avril, Maia Butsashvili, Konstantine Labartkava, Aurélie Etienne, Diane Le Pluart, Ina Inaridze, Ana Gamezardashvili, David Kharshiladze, Julie Bouscaillou
BACKGROUNDS: Georgia faces high HCV rates (5.4% of chronic cases in general population) with an epidemic concentrated among people who inject drugs (PWID). A National HCV Elimination Program (NHCEP), was launched in April 2015, aiming to eliminate HCV by 2020. To succeed, this program must develop tailored interventions to enroll PWID in treatment. INTERVENTION: We implemented a pilot intervention to facilitate access to and retention of PWID in the NHCEP, and to prevent reinfection after treatment...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29226996/breast-and-gynecological-cancer-patients-risk-factors-associated-with-biopsychosocial-problem-related-distress
#20
Cristiane Decat Bergerot, Karen Lynn Clark, Richard Obenchain, Errol J Philip, Matthew Loscalzo
OBJECTIVES: Inequalities exist between breast and gynecological cancer patients' experiences, leading to high levels of distress throughout the cancer journey. The present study aims to identify differences in source of biopsychosocial problem-related distress between women diagnosed with breast or gynecological cancers. METHODS: From 2009 to 2016 women with breast (n=2,111) and gynecological (n=641) cancers were screened using the core items of the instrument You, Your Family, and City of Hope are a Team...
December 11, 2017: Psycho-oncology
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