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High throughout screening

Duk Hwan Kim, Soo Jung Park, Jae Hee Cheon, Tae Il Kim, Won Ho Kim, Sung Pil Hong
OBJECTIVES: The objective of this study was to determine whether a pre-training program influences the entire learning process and overall proficiency of colonoscopy during fellowship. METHODS: From March 2011 to February 2013, a total of 28 first-year gastrointestinal fellows were trained in colonoscopy at a single tertiary center. Before entering their fellowship training, all fellows were board certified in internal medicine, but had no experience performing a full colonoscopy...
2016: PloS One
Ido Sagi, Dieter Egli, Nissim Benvenisty
Haploid human pluripotent stem cells (PSCs) integrate haploidy and pluripotency, providing a novel system for functional genomics and developmental research in humans. We have recently derived haploid human embryonic stem cells (ESCs) by parthenogenesis and demonstrated their wide differentiation potential and applicability for genetic screening. Because haploid cells can spontaneously become diploid, their enrichment at an early passage is key for successful derivation. In this protocol, we describe two methodologies, namely metaphase spread analysis and cell sorting, for the identification of haploid human cells within parthenogenetic ESC lines...
November 2016: Nature Protocols
Daiji Nagayama, Rena Watanabe, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
OBJECTIVE: To investigate the association of body mass index (BMI) with cardio-ankle vascular index (CAVI). DESIGN AND METHOD: We analyzed cross-sectional data from 23,257 healthy Japanese subjects (12,729 males and 10528 females) without past history of heart disease, hypertension, stroke, diabetes and nephritis between 20 and 74 (47.1 ± 12.5) years of age who underwent health screening during 2004 to 2006 in Japan. RESULTS: Male showed markedly higher BMI, CAVI, TG and lower HDL-C...
September 2016: Journal of Hypertension
Florian Richter, Ines Fonfara, Boris Bouazza, Charlotte Helene Schumacher, Majda Bratovič, Emmanuelle Charpentier, Andreas Möglich
Sensory photoreceptors have enabled non-invasive and spatiotemporal control of numerous biological processes. Photoreceptor engineering has expanded the repertoire beyond natural receptors, but to date no generally applicable strategy exists towards constructing light-regulated protein actuators of arbitrary function. We hence explored whether the homodimeric Rhodobacter sphaeroides light-oxygen-voltage (LOV) domain (RsLOV) that dissociates upon blue-light exposure can confer light sensitivity onto effector proteins, via a mechanism of light-induced functional site release...
October 15, 2016: Nucleic Acids Research
Joseph F Levy, Marjorie A Rosenberg, Philip M Farrell
BACKGROUND: Previous estimates of the cost of care for pediatric Cystic fibrosis (CF) showed wide variation, without specific summary of pulmonary drug costs. METHODS: Enrolled CF children from the Wisconsin newborn screening trial were evaluated quarterly per protocol. Assessments systematically included all treatments, hospitalizations, and nutritional and pulmonary outcomes. Direct medical costs from hospital billing and medical records from 1989 to 2010 were used to describe costs by age-ranges and subgroups throughout follow-up...
October 14, 2016: Pediatric Pulmonology
Apurv Soni, Allison Earon, Anna Handorf, Nisha Fahey, Kandarp Talati, John Bostrom, Ki Chon, Craig Napolitano, Michael Chin, John Sullivan, Shyamsundar Raithatha, Robert Goldberg, Somashekhar Nimbalkar, Jeroan Allison, Sunil Thanvi, David McManus
BACKGROUND: Atrial fibrillation, the world's most common arrhythmia, is a leading risk factor for stroke, a disease striking nearly 1.6 million Indians annually. Early detection and management of atrial fibrillation is a promising opportunity to prevent stroke but widespread screening programs in limited resource settings using conventional methods is difficult and costly. OBJECTIVE: The objective of this study is to screen people for atrial fibrillation in rural western India using a US Food and Drug Administration-approved single-lead electrocardiography device, Alivecor...
October 13, 2016: JMIR Public Health and Surveillance
Lieke J J Klinkenberg, Karin Wildi, Noreen van der Linden, Imre W K Kouw, Marijke Niens, Raphael Twerenbold, Maria Rubini Gimenez, Christian Puelacher, Jean Daniel Neuhaus, Petra Hillinger, Thomas Nestelberger, Jasper Boeddinghaus, Karin Grimm, Zaid Sabti, Judith A P Bons, Jeroen D E van Suijlen, Frans E S Tan, Joop Ten Kate, Otto Bekers, Luc J C van Loon, Marja P van Dieijen-Visser, Christian Mueller, Steven J R Meex
BACKGROUND: Interpretation of serial high-sensitivity cardiac troponin (hs-cTn) measurements for the diagnosis of acute myocardial infarction (AMI) assumes random fluctuation of hs-cTn around an individual's homeostatic set point. The aim of this study was to challenge this diagnostic concept. METHODS: Study 1 examined the presence of a diurnal hs-cTn rhythm by hourly blood sampling, day and night, in 24 individuals without a recent history of AMI. Study 2 assessed morning vs evening diagnostic accuracy of hs-cTnT and hs-cTnI in a prospective multicenter diagnostic study of 2782 unselected patients, presenting to the emergency department with acute chest pain...
October 5, 2016: Clinical Chemistry
Julia Davourie, Luke Westfall, Mohammed Ali, Doreen McGough
Life-cycle assessments (LCAs) provide a wealth of industry data to assist in evaluating the environmental impacts of industrial processes and product supply chains. In this investigation, data from a recent LCA covering global manganese alloy production was used to evaluate sources of particulate matter (PM) emissions associated with the manganese alloy supply chain. The analysis is aimed at providing an empirical, industry-averaged breakdown of the contribution that processes and emissions controls have on total emissions, manganese releases and occupational exposure...
September 28, 2016: Neurotoxicology
Alexander Aliper, Aleksey V Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G Swick, Alexey Moskalev, Alex Zhavoronkov
Populations in developed nations throughout the world are rapidly aging, and the search for geroprotectors, or anti-aging interventions, has never been more important. Yet while hundreds of geroprotectors have extended lifespan in animal models, none have yet been approved for widespread use in humans. GeroScope is a computational tool that can aid prediction of novel geroprotectors from existing human gene expression data. GeroScope maps expression differences between samples from young and old subjects to aging-related signaling pathways, then profiles pathway activation strength (PAS) for each condition...
September 24, 2016: Aging
Santiago Ávila-Ríos, Claudia García-Morales, Margarita Matías-Florentino, Karla A Romero-Mora, Daniela Tapia-Trejo, Verónica S Quiroz-Morales, Helena Reyes-Gopar, Hezhao Ji, Paul Sandstrom, Jesús Casillas-Rodríguez, Juan Sierra-Madero, Eddie A León-Juárez, Marisol Valenzuela-Lara, Carlos Magis-Rodríguez, Patricia Uribe-Zuñiga, Gustavo Reyes-Terán
BACKGROUND: WHO has developed a global HIV-drug resistance surveillance strategy, including assessment of pretreatment HIV-drug resistance. We aimed to do a nationally representative survey of pretreatment HIV-drug resistance in Mexico using WHO-recommended methods. METHODS: Among 161 Ministry of Health antiretroviral therapy (ART) clinics in Mexico, the largest, including 90% of ART initiators within the Ministry of Health (66 in total), were eligible for the survey...
September 14, 2016: Lancet HIV
Yan Zhang, Shan Lu, Rong Li
BACKGROUND: A recent study reported a positive association between elevated serum levels of angiopoietin-like protein 2 (ANGPTL2) and the development of type 2 diabetes in a general population. However, the relationship of serum ANGPTL2 levels with the risk of developing gestational diabetes mellitus (GDM) has not been reported to date. The aim of this study was to investigate the change of maternal serum ANGPTL2 concentrations in the first trimester of pregnancy and to determine whether ANGPTL2 is a biomarker for subsequent GDM development...
2016: Chinese Medical Journal
Daiji Nagayama, Rena Watanabe, Yasuhiro Watanabe, Haruki Imamura, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
OBJECTIVE: To investigate the association of body mass index (BMI) with cardio-ankle vascular index (CAVI). DESIGN AND METHOD: We analyzed cross-sectional data from 23,257 healthy Japanese subjects (12,729 males and 10528 females) without past history of heart disease, hypertension, stroke, diabetes and nephritis between 20 and 74 (47.1 ± 12.5) years of age who underwent health screening during 2004 to 2006 in Japan. RESULTS: Male showed markedly higher BMI, CAVI, TG and lower HDL-C...
September 2016: Journal of Hypertension
B T Cunningham, M Zhang, Y Zhuo, L Kwon, C Race
Photonic crystal surfaces that are designed to function as wavelength-selective optical resonators have become a widely adopted platform for label-free biosensing, and for enhancement of the output of photon-emitting tags used throughout life science research and in vitro diagnostics. While some applications, such as analysis of drug-protein interactions, require extremely high resolution and the ability to accurately correct for measurement artifacts, others require sensitivity that is high enough for detection of disease biomarkers in serum with concentrations less than 1 pg/ml...
May 15, 2016: IEEE Sensors Journal
Loredana Cavalli, Andrea Guazzini, Luisella Cianferotti, Simone Parri, Tiziana Cavalli, Alessia Metozzi, Francesca Giusti, Caterina Fossi, Dennis M Black, Maria Luisa Brandi
BACKGROUND: BoneTour is a campaign conducted throughout the Italian territory for the assessment of Italian people bone status and for the prevention of osteoporosis. METHODS: A total of 7305 sequential subjects of both sexes were screened, collecting clinical data through the FRAX™ questionnaire, and measuring heel bone stiffness by Quantitative Ultrasonography (QUS). The 10-year risk for hip and major osteoporotic fractures was calculated taking into account personal or family history of fragility fracture, smoking, alcohol abuse, rheumatoid arthritis, prolonged steroids assumption...
2016: BMC Musculoskeletal Disorders
Paul A Tiffin, Lazaro M Mwandigha, Lewis W Paton, H Hesselgreaves, John C McLachlan, Gabrielle M Finn, Adetayo S Kasim
BACKGROUND: The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of medical school. This study evaluates whether this predictive ability extends throughout the whole of undergraduate medical study and explores the potential impact of using the test as a selection screening tool...
2016: BMC Medicine
Irshad Ahmad
BACKGROUND: Viral hepatitis during pregnancy is associated with a high risk of maternal complications. The virus has a high risk of vertical transmission and it has been reported as the leading cause of maternal death. OBJECTIVES: To study the prevalence of hepatitis B (HBV) and hepatitis C (HCV) viral infections among pregnant women in the Peshawar district of Pakistan. MATERIALS AND METHODS: The cross-sectional study took place between July 2013 and April 2014...
June 2016: Hepatitis Monthly
Haocong Zhang, Yan Wang
BACKGROUND: Spinal cord injury (SCI) is highly related to the devastating sensory and motor dysfunction. METHODS: The GSE45006 gene expression profile dataset was downloaded from Gene Expression Omnibus, which was collected from 24 rats including 20 animals with injured T7 spinal cords using an aneurysm clip impact-compression injury model and killed after 1 day, 3 days, 1 week, 2 weeks, and 8 weeks and four sham-operated rats. Differentially expressed genes (DEGs) between the injured rats at each time point and the sham-operated rats were screened...
2016: Journal of Orthopaedic Surgery and Research
Guy Dubuis, Yizhak Yacoby, Hua Zhou, Xi He, Anthony T Bollinger, Davor Pavuna, Ron Pindak, Ivan Božović
We studied structural changes in a 5 unit cell thick La1.96Sr0.04CuO4 film, epitaxially grown on a LaSrAlO4 substrate with a single unit cell buffer layer, when ultra-high electric fields were induced in the film by applying a gate voltage between the film (ground) and an ionic liquid in contact with it. Measuring the diffraction intensity along the substrate-defined Bragg rods and analyzing the results using a phase retrieval method we obtained the three-dimensional electron density in the film, buffer layer, and topmost atomic layers of the substrate under different applied gate voltages...
2016: Scientific Reports
Z N Khan, S Ahmed, M Ali
Metal Oxide Semiconductor (MOS) capacitors (MOSCAP) have been instrumental in making CMOS nano-electronics realized for back-to-back technology nodes. High-k gate stacks including the desirable metal gate processing and its integration into CMOS technology remain an active research area projecting the solution to address the requirements of technology roadmaps. Screening, selection and deposition of high-k gate dielectrics, post-deposition thermal processing, choice of metal gate structure and its post-metal deposition annealing are important parameters to optimize the process and possibly address the energy efficiency of CMOS electronics at nano scales...
2016: PloS One
Charlotte Dewdney, Margaret MacDougall, Rachel Blackburn, Gavin Lloyd, Alasdair Gray
INTRODUCTION: Procedural sedation and analgesia (PSA) is commonplace in the ED. Previous studies have identified capnography as a reliable indicator of PSA-induced respiratory depression. This review investigates the potential effect on patient safety of the use of capnography in addition to standard monitoring for adult patients undergoing PSA in the ED. METHODS: MEDLINE, Embase, Scopus, CINAHL and Google Scholar were searched systematically for ED studies using capnography during PSA...
August 26, 2016: Emergency Medicine Journal: EMJ
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