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https://www.readbyqxmd.com/read/28086902/exploiting-temporal-and-nonstationary-features-in-breathing-sound-analysis-for-multiple-obstructive-sleep-apnea-severity-classification
#1
Jaepil Kim, Taehoon Kim, Donmoon Lee, Jeong-Whun Kim, Kyogu Lee
BACKGROUND: Polysomnography (PSG) is the gold standard test for obstructive sleep apnea (OSA), but it incurs high costs, requires inconvenient measurements, and is limited by a one-night test. Thus, a repetitive OSA screening test using affordable data would be effective both for patients interested in their own OSA risk and in-hospital PSG. The purpose of this research was to develop a four-OSA severity classification model using a patient's breathing sounds. METHODS: Breathing sounds were recorded from 83 subjects during a PSG test...
January 7, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28070873/animal-models-of-ptsd-a-critical-review
#2
Elizabeth I Flandreau, Mate Toth
The goals of animal research in post-traumatic stress disorder (PTSD) include better understanding the neurophysiological etiology of PTSD, identifying potential targets for novel pharmacotherapies, and screening drugs for their potential use as PTSD treatment in humans. Diagnosis of PTSD relies on a patient interview and, as evidenced by changes to the diagnostic criteria in the DSM-5, an adequate description of this disorder in humans is a moving target. Therefore, it may seem insurmountable to model the construct of PTSD in animals such as rodents...
January 10, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28063257/genetic-screen-in-drosophila-muscle-identifies-autophagy-mediated-t-tubule-remodeling-and-a-rab2-role-in-autophagy
#3
Naonobu Fujita, Wilson Huang, Tzu-Han Lin, Jean-Francois Groulx, Steve Jean, Yoshihiko Kuchitsu, Ikuko Koyama-Honda, Noboru Mizushima, Mitsunori Fukuda, Amy A Kiger
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout the contractile system despite the ongoing muscle remodeling that occurs with muscle atrophy, damage and aging. We uncovered an essential role for autophagy in T-tubule remodeling with genetic screens of a developmentally regulated remodeling program in Drosophila abdominal muscles...
January 7, 2017: ELife
https://www.readbyqxmd.com/read/28053538/inverse-relationship-of-cardioankle-vascular-index-with-bmi-in-healthy-japanese-subjects-a-cross-sectional-study
#4
Daiji Nagayama, Haruki Imamura, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
OBJECTIVE: The objective of this study is to investigate the association of body mass index (BMI) with arterial stiffness assessed by cardioankle vascular index (CAVI). SUBJECTS AND METHODS: A retrospective cross-sectional study was conducted in 23,257 healthy Japanese subjects (12,729 men and 10,528 women, aged 47.1 ± 12.5 years, BMI 22.9 ± 3.4 kg/m(2)) who underwent health screening between 2004 and 2006 in Japan. Exclusion criteria were current medication use and a past history of cardiovascular disease, hypertension, stroke, diabetes, and nephritis...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28052021/serum-hepatitis-b-core-antibody-titer-use-in-screening-for-significant-fibrosis-in-treatment-na%C3%A3-ve-patients-with-chronic-hepatitis-b
#5
Min-Ran Li, Huan-Wei Zheng, Jian-Hua Lu, Shun-Mao Ma, Li-Hong Ye, Zhi-Quan Liu, Hai-Cong Zhang, Yun-Yan Liu, Ying Lv, Yan Huang, Er-Hei Dai, Dian-Xing Sun
BACKGROUND: Previous studies have revealed that hepatitis B core antibody (anti-HBc) levels vary throughout the different phases of treatment-naïve chronic hepatitis B (CHB) patients and can be used as a predictor of treatment response in both interferon-α and nucleoside analogue therapies. However, few data have been published regarding the relationship between quantitative anti-HBc (qAnti-HBc) levels and liver fibrosis in patients with CHB. RESULTS: A total of 489 HBeAg-positive (HBeAg (+)) and 135 HBeAg-negative (HBeAg (-)) patients were recruited...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28049477/the-effect-of-small-solar-powered-b%C3%AD-k%C3%AD-%C3%AD-net-fans-on-mosquito-net-use-results-from-a-randomized-controlled-cross-over-trial-in-southern-ghana
#6
Olivier J T Briët, Joshua O Yukich, Constanze Pfeiffer, William Miller, Mulako S Jaeger, Nitin Khanna, Samuel Oppong, Peter Nardini, Collins K Ahorlu, Joseph Keating
BACKGROUND: Long-lasting insecticidal nets (LLINs) are ineffective malaria transmission prevention tools if they are unused. Discomfort due to heat is the most commonly reported reason for not using nets, but this problem is largely unaddressed. With increasing rural electrification and the dropping price of solar power, fans could improve comfort inside nets and be affordable to populations in malaria endemic areas. Here, results are presented from a pilot randomized controlled cross-over study testing the effect of fans on LLIN use...
January 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28048515/th-ab-207a-09-tailoring-tcm-schemes-to-a-task-evaluating-the-impact-of-customized-tcm-profiles-on-detection-of-lung-nodules-in-simulated-ct-lung-cancer-screening
#7
J Hoffman, F Noo, S Young, M McNitt-Gray
PURPOSE: Recent work has shown that current TCM profile designs boost detection of low-contrast lung lesions in the lung apices, but yield reduced detection performance in the mid and lower lung regions relative to fixed tube current cases. This observed imbalance suggests that the TCM scheme might be tailored in new ways to maximize nodule detection throughout the entire lung. In this work, we begin a preliminary investigation into custom TCM profiles in an attempt to achieve uniform lesion detection throughout the extent of the lung...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047992/su-f-t-94-plan2pdf-a-software-tool-for-automatic-plan-report-for-philips-pinnacle-tps
#8
C Wu
PURPOSE: To implement an automatic electronic PDF plan reporting tool for Philips Pinnacle treatment planning system (TPS) METHODS: An electronic treatment plan reporting software is developed by us to enable fully automatic PDF report from Pinnacle TPS to external EMR programs such as MOSAIQ. The tool is named "plan2pdf". plan2pdf is implemented using Pinnacle scripts, Java and UNIX shell scripts, without any external program needed. plan2pdf supports full auto-mode and manual mode reporting...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045200/quality-of-colonoscopy-performed-in-rural-practice-experience-from-the-clinical-outcomes-research-initiative-and-the-oregon-rural-practice-based-research-network
#9
Jennifer L Holub, Cynthia Morris, Lyle J Fagnan, Judith R Logan, LeAnn C Michaels, David A Lieberman
PURPOSE: Colon cancer screening is effective. To complete screening in 80% of individuals over age 50 years by 2018 will require adequate colonoscopy capacity throughout the country, including rural areas, where colonoscopy providers may have less specialized training. Our aim was to study the quality of colonoscopy in rural settings. METHODS: The Clinical Outcomes Research Initiative (CORI) and the Oregon Rural Practice-based Research Network (ORPRN) collaborated to recruit Oregon rural practices to submit colonoscopy reports to CORI's National Endoscopic Database (NED)...
January 3, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28042640/toxicology-of-microcystins-with-reference-to-cases-of-human-intoxications-and-epidemiological-investigations-of-exposures-to-cyanobacteria-and-cyanotoxins
#10
REVIEW
Zorica Svirčev, Damjana Drobac, Nada Tokodi, Biljana Mijović, Geoffrey A Codd, Jussi Meriluoto
Blooms of cyanobacteria have been documented throughout history, all over the world. Mass populations of these organisms typically present hazards to human health and are known for the production of a wide range of highly toxic metabolites-cyanotoxins, of which among the most common and most investigated are the microcystins. The toxicity of the family of microcystin congeners to animal and cell models has received much attention; however, less is known about their negative effects on human health, whether via acute or chronic exposure...
January 2, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28035693/identification-of-a-u-zn-cu-responsive-global-regulatory-two-component-system-in-caulobacter-crescentus
#11
Dan M Park, K Wesley Overton, Megan J Liou, Yongqin Jiao
Despite the well-known toxicity of uranium (U) to bacteria, little is known about how cells sense and respond to U. The recent finding of a U-specific stress response in Caulobacter crescentus has provided a foundation for studying the mechanisms of U- perception in bacteria. To gain insight into this process, we used a forward genetic screen to identify the regulatory components governing expression of the urcA promoter (PurcA ) that is strongly induced by U. This approach unearthed a previously uncharacterized two-component system, named UzcRS, which is responsible for U-dependent activation of PurcA ...
December 30, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/28034363/the-screening-of-novel-inhibitors-against-leishmania-donovani-calcium-ion-channel-to-fight-leishmaniasis
#12
Mohammad Kashif, Partha Pratim Manna, Yusuf Akhter, Mohammed Alaidarous, Abdur Rub
Leishmania is an intracellular protozoan parasite which causes Leishmaniasis, a global health problem affecting millions of people throughout 89 different countries in the world. The current treatment which includes use of amphotericin B, antimonials, and others has major drawbacks due to toxicity, resistance, and extraordinary high cost. So there is an urgent need of development of new drug targets to fight against leishmaniasis. In this regard we have selected Leishmania donovani Ca2+ ion channel (Ld-CC) as potential drug target...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28018175/progressive-seizure-aggravation-in-the-repeated-6-hz-corneal-stimulation-model-is-accompanied-by-marked-increase-in-hippocampal-p-erk1-2-immunoreactivity-in-neurons
#13
Carmela Giordano, Anna M Costa, Chiara Lucchi, Giuseppina Leo, Luc Brunel, Jean-Alain Fehrentz, Jean Martinez, Antonio Torsello, Giuseppe Biagini
The 6-Hz corneal stimulation test is used to screen novel antiepileptic molecules to overcome the problem of drug refractoriness. Although recognized as a standard test, it has been evaluated only recently in the attempt to characterize the putative neuronal networks involved in seizures caused by corneal stimulation. In particular, by recording from the CA1 region we previously established that the hippocampus participates to propagation of seizure activity. However, these findings were not corroborated by using markers of neuronal activation such as FosB/ΔFosB antigens...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27999334/hybridization-capture-based-next-generation-sequencing-to-evaluate-coding-sequence-and-deep-intronic-mutations-in-the-nf1-gene
#14
Karin Soares Cunha, Nathalia Silva Oliveira, Anna Karoline Fausto, Carolina Cruz de Souza, Audrey Gros, Thomas Bandres, Yamina Idrissi, Jean-Philippe Merlio, Rodrigo Soares de Moura Neto, Rosane Silva, Mauro Geller, David Cappellen
Neurofibromatosis 1 (NF1) is one of the most common genetic disorders and is caused by mutations in the NF1 gene. NF1 gene mutational analysis presents a considerable challenge because of its large size, existence of highly homologous pseudogenes located throughout the human genome, absence of mutational hotspots, and diversity of mutations types, including deep intronic splicing mutations. We aimed to evaluate the use of hybridization capture-based next-generation sequencing to screen coding and noncoding NF1 regions...
December 17, 2016: Genes
https://www.readbyqxmd.com/read/27996962/an-atlas-of-transcriptional-chromatin-accessibility-and-surface-marker-changes-in-human-mesoderm-development
#15
Pang Wei Koh, Rahul Sinha, Amira A Barkal, Rachel M Morganti, Angela Chen, Irving L Weissman, Lay Teng Ang, Anshul Kundaje, Kyle M Loh
Mesoderm is the developmental precursor to myriad human tissues including bone, heart, and skeletal muscle. Unravelling the molecular events through which these lineages become diversified from one another is integral to developmental biology and understanding changes in cellular fate. To this end, we developed an in vitro system to differentiate human pluripotent stem cells through primitive streak intermediates into paraxial mesoderm and its derivatives (somites, sclerotome, dermomyotome) and separately, into lateral mesoderm and its derivatives (cardiac mesoderm)...
December 20, 2016: Scientific Data
https://www.readbyqxmd.com/read/27992095/faecal-occult-blood-testing-screening-for-colorectal-cancer-and-missed-interval-cancers-are-we-ignoring-the-elephant-in-the-room-results-of-a-multicentre-study
#16
A T George, S Aggarwal, S Dharmavaram, A Menon, M Dube, M Vogler, A Field
AIM: Biennial faecal occult testing (FOBT) is used to screen for colorectal cancer throughout the United Kingdom (UK). Interval cancers are tumours that develop in patients between screening rounds who have had a negative FOBT. Through a multicentre study, we compared demographics of patients with interval cancers, FOBT screen detected cancers and cancers that developed in patients who chose not to participate in the screening programme. METHOD: Five hundred and sixteen colorectal cancers were detected in the screening age group (60-74 years) population in three United Kingdom NHS Hospitals over two years...
December 19, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27979753/healthy-caregivers-healthy-children-hc2-phase-2-integrating-culturally-sensitive-childhood-obesity-prevention-strategies-into-childcare-center-policies
#17
Sarah E Messiah, Cynthia Lebron, Rhoda Moise, M Sunil Mathew, Krystal Sardinas, Catherina Chang, Joanne Palenzuela, Jennifer Walsh, Karla P Shelnutt, Rachel Spector, Fiorella Altare, Ruby Natale
OBJECTIVE: Despite the high prevalence of obesity among preschool-aged children, most states lack childcare center (CCC) nutrition and physical activity policies. The Healthy Caregivers, Healthy Children (HC) Phase 2 project is examining the relationship between the CCC nutrition and physical activity environment and child dietary intake/physical activity patterns and body mass index (BMI). PARTICIPANTS: A total of 24 "Quality Counts" (Miami Dade County, Florida's Quality Rating Improvement System [QRIS)]) CCCs serving low resource families with ≥50 2-to-5year olds attending have been randomized to either intervention (n=12) or control (n=12)...
December 12, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27974006/safety-and-effectiveness-of-therapeutic-magnetic-resonance-in-diabetic-foot-ulcers-a-prospective-randomised-controlled-trial
#18
A Piaggesi, M Sambataro, C Nicoletti, C Goretti, E Lacopi, A Coppelli
OBJECTIVE: To test the efficacy and safety of therapeutic magnetic resonance (TMR) in the management of diabetic foot ulcers (DFU), the authors designed a prospective randomised controlled trial in three highly specialised diabetic foot clinics. METHOD: All the patients consecutively visited in a period of 18 months were screened according to the inclusion (presence of an ulcer >1 cm(2) in the foot lasting at least 6 weeks; ABPI>0.6; consent to participate in the study) and exclusion (Charcot's foot; local or systemic infections; chronic renal failure; any wearable electrically-driven life-supporting device) criteria...
December 2, 2016: Journal of Wound Care
https://www.readbyqxmd.com/read/27964869/relapse-to-opioid-use-in-opioid-dependent-individuals-released-from-compulsory-drug-detention-centres-compared-with-those-from-voluntary-methadone-treatment-centres-in-malaysia-a-two-arm-prospective-observational-study
#19
Martin P Wegman, Frederick L Altice, Sangeeth Kaur, Vanesa Rajandaran, Sutayut Osornprasop, David Wilson, David P Wilson, Adeeba Kamarulzaman
BACKGROUND: Detention of people who use drugs into compulsory drug detention centres (CDDCs) is common throughout East and Southeast Asia. Evidence-based pharmacological therapies for treating substance use disorders, such as opioid agonist treatments with methadone, are generally unavailable in these settings. We used a unique opportunity where CDDCs coexisted with voluntary drug treatment centres (VTCs) providing methadone in Malaysia to compare the timing and occurrence of opioid relapse (measured using urine drug testing) in individuals transitioning from CDDCs versus methadone maintenance in VTCs...
December 7, 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27956531/clr-a-a-novel-immune-related-c-type-lectin-like-molecule-exclusively-expressed-by-mouse-gut-epithelium
#20
Emilia Rutkowski, Stefan Leibelt, Christina Born, Miriam E Friede, Stefan Bauer, Sandra Weil, Joachim Koch, Alexander Steinle
The mouse gut epithelium represents a constitutively challenged environment keeping intestinal commensal microbiota at bay and defending against invading enteric pathogens. The complex immunoregulatory network of the epithelial barrier surveillance also involves NK gene complex (NKC)-encoded C-type lectin-like molecules such as NKG2D and Nkrp1 receptors. To our knowledge, in this study, we report the first characterization of the orphan C-type lectin-like molecule Clr-a encoded by the Clec2e gene in the mouse NKC...
December 12, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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