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https://www.readbyqxmd.com/read/28431450/-livestock-associated-methicillin-resistant-staphylococcus-aureus-epidemiological-data-from-an-orthopaedic-department-in-north-west-germany
#1
Gerrit Steffen Maier, Fritz Thorey, Kristina Kolbow, Djordje Lazovic, Markus Lühmann, Jörg Ohnsorge, Uwe Maus
Background MRSA represents a considerable health threat to orthopaedic patients. Throughout the last decade, livestock-associated MRSA emerged increasingly in livestock all over Europe. LA-MRSA broke the species barrier, colonizing and causing infections in humans. Nevertheless, to date there are no studies concerning livestock-associated MRSA and orthopaedic patients. Therefore, we aimed to investigate the prevalence of LA-MRSA in a regional orthopaedic department localized in an area with high-density livestock...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28427570/high-resolution-mass-spectrometry-based-screening-reveals-lipophilic-toxins-in-multiple-trophic-levels-from-the-north-sea
#2
Gabriel Orellana, Lieven Van Meulebroek, Maarten De Rijcke, Colin R Janssen, Lynn Vanhaecke
Lipophilic marine biotoxins, which are mainly produced by small dinoflagellates, are increasingly detected in coastal waters across the globe. As these producers are consumed by zooplankton and shellfish, the toxins are introduced, bioaccumulated and possibly biomagnified throughout marine food chains. Recent research has demonstrated that ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) is an excellent tool to detect marine toxins in algae and seafood. In this study, UHPLC-HRMS was used to screen lipophilic marine biotoxins in organisms from different trophic levels of the Belgian coastal zone ecosystem...
April 2017: Harmful Algae
https://www.readbyqxmd.com/read/28411225/genome-wide-search-for-ionizing-radiation-responsive-elements-in-deinococcus-radiodurans-reveals-regulatory-role-of-the-dna-gyrase-subunit-a-5-utr-in-the-radiation-and-desiccation-response-rdr
#3
Jordan K Villa, Paul Amador, Justin Janovsky, Arijit Bhuyan, Roland Saldanha, Thomas J Lamkin, Lydia M Contreras
Tight regulation of gene expression is important for Deinococcus radiodurans survival, a model bacterium of extreme stress resistance. Few studies have examined the use of regulatory RNAs as a possible contributing mechanism to ionizing radiation (IR) resistance, despite their proffered efficient and dynamic gene expression regulation under IR stress. This work presents a transcriptome-based approach for identification of stress-responsive regulatory 5' UTR elements in D. radiodurans R1 that can be broadly applied to other bacteria...
April 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28409029/biophysical-approaches-facilitate-computational-drug-discovery-for-atp-binding-cassette-proteins
#4
REVIEW
Steven V Molinski, Zoltán Bozóky, Surtaj H Iram, Saumel Ahmadi
Although membrane proteins represent most therapeutically relevant drug targets, the availability of atomic resolution structures for this class of proteins has been limited. Structural characterization has been hampered by the biophysical nature of these polytopic transporters, receptors, and channels, and recent innovations to in vitro techniques aim to mitigate these challenges. One such class of membrane proteins, the ATP-binding cassette (ABC) superfamily, are broadly expressed throughout the human body, required for normal physiology and disease-causing when mutated, yet lacks sufficient structural representation in the Protein Data Bank...
2017: International Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28407947/tuneable-surface-enhanced-raman-spectroscopy-hyphenated-to-chemically-derivatized-thin-layer-chromatography-plates-for-screening-histamine-in-fish
#5
Zhengjun Xie, Yang Wang, Yisheng Chen, Xueming Xu, Zhengyu Jin, Yunlian Ding, Na Yang, Fengfeng Wu
Reliable screening of histamine in fish was of urgent importance for food safety. This work presented a highly selective surface enhanced Raman spectroscopy (SERS) method mediated by thin-layer chromatography (TLC), which was tailored for identification and quantitation of histamine. Following separation and derivatization with fluram, plates were assayed with SERS, jointly using silver nanoparticle and NaCl. The latter dramatically suppressed the masking effect caused by excessive fluram throughout the plate, thus offering clear baseline and intensive Raman fingerprints specific to the analyte...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28401632/role-of-four-dimensional-echocardiography-with-high-definition-flow-imaging-and-spatiotemporal-image-correlation-in-detecting-fetal-pulmonary-veins
#6
Xue Sun, Ying Zhang, Miao Fan, Yu Wang, Meilian Wang, Faiza Amber Siddiqui, Wei Sun, Feifei Sun, Dongyu Zhang, Wenjia Lei, Guyue Hu
BACKGROUND: Prenatal diagnosis of fetal total anomalous pulmonary vein connection (TAPVC) remains challenging for most screening sonographers. The purpose of this study was to evaluate the use of four-dimensional echocardiography with high-definition flow imaging and spatiotemporal image correlation (4D-HDFI) in identifying pulmonary veins in normal and TAPVC fetuses. MATERIAL & METHODS: We retrospectively reviewed and performed 4D-HDFI in 204 normal and 12 fetuses with confirmed diagnosis of TAPVC...
April 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28396446/identification-of-a-cono-rfamide-from-the-venom-of-conus-textile-that-targets-asic3-and-enhances-muscle-pain
#7
Catharina Reimers, Cheng-Han Lee, Hubert Kalbacher, Yuemin Tian, Chih-Hsien Hung, Axel Schmidt, Lea Prokop, Silke Kauferstein, Dietrich Mebs, Chih-Cheng Chen, Stefan Gründer
Acid-sensing ion channels (ASICs) are proton-gated Na(+) channels that are expressed throughout the nervous system. ASICs have been implicated in several neuronal disorders, like ischemic stroke, neuronal inflammation, and pathological pain. Several toxins from venomous animals have been identified that target ASICs with high specificity and potency. These toxins are extremely useful in providing protein pharmacophores and to characterize function and structure of ASICs. Marine cone snails contain a high diversity of toxins in their venom such as conotoxins, which are short polypeptides stabilized by disulfide bonds, and conopeptides, which have no or only one disulfide bond...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28392974/-knowing-what-matters-in-diabetes-healthier-below-7-results-of-the-campaign-s-first-10-years-part-2-participants-without-known-diabetes-history
#8
Stephan Jacob, Andrea Klimke-Huebner, Franz W Dippel, Werner Hopfenmueller
INTRODUCTION: Type 2 diabetes represents a major problem in many societies. Early detection and, even better, prevention could help to reduce the burden of the disease. Therefore, increased awareness of disorders of glucose metabolism is important. During the campaign 'Knowing what Matters in diabetes: Healthier below 7', in the last few years, more than 31 000 shopping mall visitors in Germany were voluntarily checked for their potential diabetes risk. METHODS: With a modified FINDRISK questionnaire, demographic, anthropometric and anamnestic data relevant for the estimation of the potential diabetes risk were collected...
March 2017: Cardiovascular Endocrinology
https://www.readbyqxmd.com/read/28371708/comprehensive-strategy-for-pesticide-residue-analysis-through-the-production-cycle-of-gilthead-sea-bream-and-atlantic-salmon
#9
T Portolés, M Ibáñez, B Garlito, J Nácher-Mestre, V Karalazos, J Silva, M Alm, R Serrano, J Pérez-Sánchez, F Hernández, M H G Berntssen
Plant ingredients and processed animal proteins are alternative feedstuffs for fish feeds in aquaculture. However, their use can introduce contaminants like pesticides that are not previously associated with marine Atlantic salmon and gilthead sea bream farming. This study covers the screening of around 800 pesticides by gas chromatography (GC) and liquid chromatography (LC) coupled to high resolution time-of-flight mass spectrometry in matrices throughout the entire marine food production chain. Prior to analysis of real-world samples, the screening methodology was validated for 252 pesticides to establish the screening detection limit...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28360387/genetic-structure-of-pseudococcus-microcirculus-hemiptera-pseudococcidae-populations-on-epiphytic-orchids-in-south-florida
#10
J A Zettler, K Adams, B Frederick, A Gutting, N Ingebretsen, A Ragsdale, A Schrey
In 2012, the orchid mealy bug Pseudococcus microcirculus was first detected in situ in North America's more diverse orchid region, the Big Cypress Basin (Collier Co FL). A follow-up survey showed that the mealy bug is more widespread and found on epiphytic orchids in two locations, in both the Fakahatchee Strand State Preserve (sites B and F) and the Florida Panther National Wildlife Refuge (sites M and C). There, we collected mealy bugs (n = 54) from 35 orchid individuals and screened allelic variation at seven microsatellite loci...
March 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28349236/concurrent-trajectories-of-female-drinking-and-smoking-behaviors-throughout-transitions-to-pregnancy-and-early-parenthood
#11
Weiwei Liu, Elizabeth A Mumford
The purpose of this longitudinal study was to investigate whether there are distinct etiological processes explaining dual usage of alcohol and conventional cigarettes by mothers from preconception through the early parenting years. Data on 8800 biological mothers were drawn from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), representative of US births in 2001. A general growth mixture model (GGMM) was used to empirically identify developmental trajectories of maternal smoking and drinking over the 5-6-year study period...
March 27, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28346680/human-papillomavirus-in-cervical-cancer-and-oropharyngeal-cancer-one-cause-two-diseases
#12
REVIEW
Tara A Berman, John T Schiller
Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the second most common cause of death from cancer in women worldwide, as developing countries lack resources for universal, high-quality screening. In the United States, HPV-related OPC is only 1 of 5 cancers with a rising incidence since 1975 and now has taken over the cervix as the most common site of HPV-related cancer...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28342321/improvement-of-paracellular-transport-in-the-caco-2-drug-screening-model-using-protein-engineered-substrates
#13
Rebecca L DiMarco, Daniel R Hunt, Ruby E Dewi, Sarah C Heilshorn
The Caco-2 assay has achieved wide popularity among pharmaceutical companies in the past two decades as an in vitro method for estimation of in vivo oral bioavailability of pharmaceutical compounds during preclinical characterization. Despite its popularity, this assay suffers from a severe underprediction of the transport of drugs which are absorbed paracellularly, that is, which pass through the cell-cell tight junctions of the absorptive cells of the small intestine. Here, we propose that simply replacing the collagen I matrix employed in the standard Caco-2 assay with an engineered matrix, we can control cell morphology and hence regulate the cell-cell junctions that dictate paracellular transport...
March 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28339845/expanded-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolated-from-chickens-with-colibacillosis-in-egypt
#14
D A El-Shazly, S A Nasef, F F Mahmoud, Daniel Jonas
Throughout the world, expanded spectrum β-lactamases (ESBL) are increasing among clinical isolates of Enterobacteriaceae, both in humans and animals. Unfortunately, there is a paucity of data on ESBL or Ampicillin class C β-lactamase (AmpC) in Egypt, although antimicrobial consumption is high in this developing country. This study aims to characterize the resistance mechanisms to expanded spectrum cephalosporins among resistant veterinary Escherichia coli isolates in Egypt. We investigated 50 clinical multi-resistant E...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28336382/migration-and-infectious-diseases
#15
REVIEW
F Castelli, G Sulis
BACKGROUND: Infectious diseases still represent an important cause of morbidity and mortality among foreign-born individuals. The rising migration flows towards Europe throughout the last few years are raising renewed concerns about management issues and the potential associated risk for the native population. AIMS: To discuss the health implications and challenges related to the four phases of migration, from first arrival to stable resettlement. SOURCES: Scientific literature and relevant statistical reports...
March 20, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28335860/-muscling-throughout-life-integrating-studies-of-muscle-development-homeostasis-and-disease-in-zebrafish
#16
Michelle F Goody, Erin V Carter, Elisabeth A Kilroy, Lisa Maves, Clarissa A Henry
The proper development and function of skeletal muscle is vital for health throughout the lifespan. Skeletal muscle function enables posture, breathing, and locomotion; and also impacts systemic processes-such as metabolism, thermoregulation, and immunity. Diseases of skeletal muscle (myopathies, muscular dystrophies) and even some neurological, age-related, and metabolic diseases compromise muscle function and negatively affect health span and quality of life. There have been numerous, recent examples of studies on skeletal muscle development with exciting, therapeutic implications for muscle diseases...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28332639/evaluation-of-the-bacteriological-quality-of-raw-cow-s-milk-at-various-stages-of-the-milk-production-chain-on-farms-in-algeria-%C3%A2-oie-world-organisation-for-animal-health-2016
#17
M Hamiroune, A Berber, S Boubekeur
This study evaluates hygiene practices on 53 dairy farms in the Jijel and Blida regions of Algeria. A survey questionnaire was drawn up covering milking conditions and cleaning of the equipment. In parallel, bacteriological analyses were carried out to estimate the rate, source and development of bacterial contamination in raw milk produced on the farm. In addition, screening was performed to detect the presence of inhibitor residues. The results of the survey revealed poor livestock conditions and milking practices that could explain the presence of bacteria in cow's milk...
December 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28329059/anticoagulation-for-pregnant-women-with-mechanical-heart-valves-a-systematic-review-and-meta-analysis
#18
Rohan D'Souza, Jackie Ostro, Prakesh S Shah, Candice K Silversides, Ann Malinowski, Kellie E Murphy, Mathew Sermer, Nadine Shehata
Aims: To review maternal and foetal outcomes in women with mechanical heart valves (MHVs) treated with vitamin-K antagonists (VKAs), first-trimester heparin followed by VKAs (sequential treatment), low molecular weight heparin (LMWH) and unfractionated heparin (UFH) during pregnancy, in order to inform practice. Methods and results: Medline, Embase and Central were searched from inception until February 2016. Two reviewers independently screened 1786 titles, reviewed 110 full-texts and extracted data and assessed risk-of-bias from 46 articles...
March 9, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28322884/cardiovascular-disease-screening-in-general-practice-general-practitioner-recording-of-common-risk-factors
#19
Lyle R Turner, Flavia Cicuttini, Christopher Pearce, Danielle Mazza
The assessment and screening of individual risk factors for cardiovascular disease (CVD) is a critical component of CVD prevention strategies in general practice (GP). This study sought to examine current CVD risk factor recording as recommended by Australian guidelines for the management of absolute cardiovascular disease risk. A retrospective analysis of routine GP data from 149,306 GP patients aged 45years and above in eastern Melbourne was conducted. Data were collected from GP clinics located throughout inner east Melbourne from July 2011 to September 2014 through the Melbourne East Monash General Practice Database...
March 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28322758/increased-seat-dump-angle-in-a-manual-wheelchair-is-associated-with-changes-in-thoracolumbar-lordosis-and-scapular-kinematics-during-propulsion
#20
Beth A Cloud, Kristin D Zhao, Arin M Ellingson, Ahmad Nassr, Anthony J Windebank, Kai-Nan An
OBJECTIVE: To quantify and compare spinal curvature and shoulder kinematics throughout the manual wheelchair propulsion cycle for individuals with spinal cord injury (SCI) who were seated at 2 different seat dump angles. DESIGN: Single-group, repeated-measures study. SETTING: Academic medical center. PARTICIPANTS: Twenty-eight individuals completed the telephone screening; 21 were eligible and completed the study. INTERVENTIONS: Participants' personal manual wheelchairs were modified to have seat dump angles of 0° or 14°, with a vertical backrest...
March 18, 2017: Archives of Physical Medicine and Rehabilitation
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