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il 17 inhibition

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https://www.readbyqxmd.com/read/29331376/microrna-425-facilitates-pathogenic-th17-cell-differentiation-by-targeting-forkhead-box-o1-foxo1-and-is-associated-with-inflammatory-bowel-disease
#1
Xue Yang, Qinyu He, Zhenzhen Guo, Fei Xiong, Yi Li, Yan Pan, Caiping Gao, Liangping Li, Chong He
Inflammatory bowel disease (IBD) is a chronic autoimmune disease, and its pathogenesis remains mostly unknown. MicroRNAs (miRs) has drawn much attention as a crucial regulator of autoimmune diseases. In this study, we demonstrated, for the first time, that miR-425 was significantly up-regulated in peripheral blood mononuclear cells (PBMC) and mucosa of patients with IBD. In note, T helper (Th) 17 cells were found to be the major source of miR-425 expression. Using gain-of-function approaches, we demonstrated that miR-425 could facilitate the differentiation of CD4+ T cells into Th17 lineage...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29330324/betaine-ameliorates-experimental-autoimmune-encephalomyelitis-by-inhibiting-dendritic-cell-derived-il-6-production-and-th17-differentiation
#2
Cuixia Yang, Weiming Lai, Jinfeng Zhou, Xinyuan Zheng, Yingying Cai, Wanjie Yang, Sirong Xie, Yuan Gao, Changsheng Du
IL-17-secreting T cells (Th17 cells) play a pathogenic role in multiple autoimmune diseases, including multiple sclerosis (MS), and dendritic cell (DC)-derived cytokines play pivotal roles in promoting the differentiation of naive CD4+ T cells into Th cell subsets (Th1 and Th17). Therefore, small molecules blocking the key cytokines produced by DCs will be beneficial in MS. In this article, we report that betaine treatment ameliorates MS pathogenesis by inhibiting DC-derived IL-6 production and Th17 differentiation...
January 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29325294/-effects-of-lactobacillus-paracasei-n1115-combined-with-fructooligosaccharides-on-non-alcoholic-fatty-liver-disease-induced-by-high-fat-diet-in-mice
#3
F F Yao, P Y Zheng, H Huang, L M Bai, Y R Ding, L Mei, S M Liu
Objective: To investigate the effects of Lactobacillus paracasei N1115 combined with fructooligosaccharides (FOS) on non-alcoholic fatty liver disease (NAFLD) in mice and its possible mechanism. Methods: A total of 50 male C57 mice were randomly and equally divided into five experimental groups. Group 1 received a normal diet (ND). Other four groups received a high-fat diet (HFD) to establish NAFLD models. In addition to HFD, group 3 received Lactobacillus paracasei N1115 (2.2×10(9) CFU/mL), group 4 received FOS (4 g/kg per day), and group 5 received Lactobacillus paracasei N1115 (2...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29305939/ablation-of-interleukin-17-alleviated-cardiac-interstitial-fibrosis-and-improved-cardiac-function-via-inhibiting-long-non-coding-rna-ak081284-in-diabetic-mice
#4
Yang Zhang, Yi-Yuan Zhang, Ting-Ting Li, Jin Wang, Yuan Jiang, Yue Zhao, Xue-Xin Jin, Gen-Long Xue, Ying Yang, Xiao-Fang Zhang, Yang-Yang Sun, Zhi-Ren Zhang, Xu Gao, Zhi-Min Du, Yan-Jie Lu, Bao-Feng Yang, Zhen-Wei Pan
Interleukin 17 (IL-17) plays an important role in the pathogenesis of cardiac interstitial fibrosis. In this study, we explored the role of interleukin-17 in the development of diabetic cardiomyopathy and the underlying mechanisms. The level of IL-17 increased in both the serum and cardiac tissue of diabetic mice. Knockout of IL-17 improved cardiac function of diabetic mice induced by streptozotocin (STZ), and significantly alleviated interstitial fibrosis as manifested by reduced collagen mRNA expression and collagen deposition evaluated by Masson's staining...
January 3, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29305916/pkc-%C3%AE-%C3%AE-regulates-th17-differentiation-and-house-dust-mite-induced-allergic-airway-inflammation
#5
Yingying Yang, Panpan Dong, Jing Zhao, Wei Zhou, Yonghua Zhou, Yongliang Xu, Congjin Mei, Fukun Guo, Yi Zheng, Jun-Qi Yang
Asthma is a chronic airway inflammation in which Th2 and Th17 cells play critical roles in its pathogenesis. We have reported that atypical protein kinase (PKC) λ/ι is a new regulator for Th2 differentiation and function. However, the role of PKCλ/ι for Th17 cells remains elusive. In this study, we explored the effect of PKCλ/ι on Th17 cells in the context of ex vivo cell culture systems and an in vivo murine model of allergic airway inflammation with the use of activated T cell-specific conditional PKCλ/ι-deficient mice...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29301573/dengue-virus-causes-changes-of-microrna-genes-regulatory-network-revealing-potential-targets-for-antiviral-drugs
#6
Mohamed Shahen, Zihu Guo, Akhtar Hussain Shar, Reham Ebaid, Qin Tao, Wenjuan Zhang, Ziyin Wu, Yaofei Bai, Yingxue Fu, Chunli Zheng, He Wang, Piar Ali Shar, Jianling Liu, Zhenzhong Wang, Wei Xiao, Yonghua Wan
BACKGROUND: Dengue virus (DENV) is an increasing global health threat and associated with induction of both a long-lived protective immune response and immune-suppression. So far, the potency of treatment of DENV via antiviral drugs is still under investigation. Recently, increasing evidences suggest the potential role of microRNAs (miRNAs) in regulating DENV. The present study focused on the function of miRNAs in innate insusceptible reactions and organization of various types of immune cells and inflammatory responses for DENV...
January 4, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29301301/immunosuppressive-effect-of-geniposide-on-mitogen-activated-protein-kinase-signalling-pathway-and-their-cross-talk-in-fibroblast-like-synoviocytes-of-adjuvant-arthritis-rats
#7
Feng Li, Miaomiao Dai, Hong Wu, Ran Deng, Jun Fu, Zhengrong Zhang, Li Dai, Wenyu Wang, Xuejing Dai, Xiang Zhan, Yan Wang
Geniposide (GE), an iridoid glycoside compound derived from Gardenia jasminoides Ellis fruit, is known to have anti-inflammatory and immunoregulatory activities. The aim of this study was to investigate the protective mechanism of GE in the regulation of the mitogen-activated protein kinase (MAPK) signalling pathway and the cross-talk among the MAPK signalling pathway in fibroblast-like synoviocytes (FLS) of adjuvant arthritis (AA) rats. AA was induced by injecting with Freund's complete adjuvant. Male SD rats and FLS were subjected to treatment with GE (30, 60 and 120 mg/kg) in vivo from day 14 to 21 after immunization and GE (25, 50 and 100 μg/mL) in vitro, respectively...
January 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29299950/interleukin-17-promotes-the-production-of-underglycosylated-iga1-in-dakiki-cells
#8
Jia-Ru Lin, Ji Wen, Hui Zhang, Li Wang, Fang-Fang Gou, Man Yang, Jun-Ming Fan
BACKGROUND: Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN). This study aimed to investigate the effect of IL-17 on autoimmune pathogenesis in IgA nephropathy. METHODS: DAKIKI cells were cultured and stimulated with IL-17 to perform dose-dependent and time-dependent experiments. Cell proliferation was examined by cell counting and the Cell Counting Kit-8 (CCK-8) assay. The IgA concentration and the degree of galactosylation in the supernatant were tested using ELISA and a helix aspersa (HAA) lectin binding assay, respectively...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29295585/topical-application-of-glycolipids-from-isochrysis-galbana-prevents-epidermal-hyperplasia-in-mice
#9
Azahara Rodríguez-Luna, Elena Talero, María Del Carmen Terencio, María Luisa González-Rodríguez, Antonio M Rabasco, Carolina de Los Reyes, Virginia Motilva, Javier Ávila-Román
Chronic inflammatory skin diseases such as psoriasis have a significant impact on society. Currently, the major topical treatments have many side effects, making their continued use in patients difficult. Microalgae have emerged as a source of bio-active molecules such as glycolipids with potent anti-inflammatory properties. We aimed to investigate the effects of a glycolipid (MGMG-A) and a glycolipid fraction (MGDG) obtained from the microalga Isochrysis galbana on a TPA-induced epidermal hyperplasia murine model...
December 25, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29284473/involvements-of-p38-mapk-and-oxidative-stress-in-the-ozone-induced-enhancement-of-ahr-and-pulmonary-inflammation-in-an-allergic-asthma-model
#10
Aihua Bao, Hong Yang, Jie Ji, Yuqin Chen, Wuping Bao, Feng Li, Min Zhang, Xin Zhou, Qiang Li, Suqin Ben
BACKGROUND: Exposure to ambient ozone (O3) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O3 to trigger asthma exacerbations are still unclear. METHODS: An ovalbumin (OVA)-established asthmatic mouse model was selected to expose to filtered air (OVA-model) or 1.0 ppm O3 (OVA-O3 model) during the process of OVA challenge. Next, the possible involvements of p38 MAPK and oxidative stress in the ozone actions on the asthma exacerbations were investigated on the mice of OVA-O3 model by treating them with SB239063 (a p38 MAPK inhibitor), and/or the α-tocopherol (antioxidant)...
December 29, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29278210/biologics-in-inflammatory-and-immunomediated-arthritis
#11
Michele Maria Luchetti, Devis Benfaremo, Armando Gabrielli
BACKGROUND: Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spondyloarthritis. METHODS: Several compounds targeting different pathways have been marketed and approved for the treatment of inflammatory arthritis, with a significant impact on the clinical outcomes and the natural history of the diseases...
December 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29275848/mir-23b-suppresses-leukocyte-migration-and-pathogenesis-of-experimental-autoimmune-encephalomyelitis-by-targeting-ccl7
#12
Yuan Zhang, Juan-Juan Han, Xiao-Yan Liang, Li Zhao, Fei Zhang, Javad Rasouli, Zhe-Zhi Wang, Guang-Xian Zhang, Xing Li
MicroRNAs (miRNAs) are small, non-coding RNAs involved in immune response regulation. Specific miRNAs have been linked to the development of various autoimmune diseases; however, their contribution to the modulation of CNS-directed cellular infiltration remains unclear. In this study, we found that miR-23b, in addition to its reported functions in the suppression of IL-17-associated autoimmune inflammation, halted the progression of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by directly inhibiting the migration of pathogenic leukocytes to the CNS...
November 26, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29273710/urinary-potassium-is-a-potential-biomarker-of-disease-activity-in-ulcerative-colitis-and-displays-in-vitro-immunotolerant-role
#13
Sandeep Goyal, Ritika Rampal, Saurabh Kedia, Sandeep Mahajan, Sawan Bopanna, Devesh P Yadav, Saransh Jain, Amit Kumar Singh, Md Nahidul Wari, Govind Makharia, Amit Awasthi, Vineet Ahuja
We evaluated the in-vitro effect of potassium on CD4+ T cells and the role of urinary potassium as a potential biomarker of disease activity in patients with ulcerative colitis (UC). This prospective observational cohort study included healthy controls (n = 18) and UC patients [n = 30, median age: 40 (IQR: 28-46) years, 17 males)] with active disease(assessed by Mayo score) from September 2015-May 2016. Twenty-four hours urinary potassium along with fecal calprotectin (FCP) were estimated in UC patients (at baseline and follow-up after 3-6 months) and controls...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246798/dlx3-dependent-stat3-signaling-in-keratinocytes-regulates-skin-immune-homeostasis
#14
Shreya Bhattacharya, Jin-Chul Kim, Youichi Ogawa, Gaku Nakato, Veronica Nagle, Stephen R Brooks, Mark C Udey, Maria I Morasso
Epidermal specific deletion of the homeobox transcription regulator DLX3 disrupts keratinocyte differentiation and results in an IL-17-linked psoriasis-like skin inflammation. To identify the epidermal initiating signals produced by DLX3-null keratinocytes, we performed acute deletion of DLX3 in adult epidermis using a tamoxifen-inducible Krt14-cre/ERT system. K14CreERT;DLX3fl/fl (icKO) skin exhibited dysregulated expression of differentiation-associated genes, upregulation of proinflammatory cytokines, and accumulation of Langerhans cells and macrophages within 3 days of tamoxifen-induced DLX3 ablation...
December 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29239790/anti-inflammatory-profile-of-aegle-marmelos-l-correa-bilva-with-special-reference-to-young-roots-grown-in-different-parts-of-india
#15
Azad Rajaram, G R Vanaja, Preeti Vyakaranam, Aparna Rachamallu, Gorla V Reddy, Kotha Anilkumar, Kalle M Arunasree, Anurag Dhyani, Narapureddy Krishna Prasad, Sakshee Sharma, Mahesh Chandra Joshi, Gaya Prasad Kimothi, N B Brindavanam, Pallu Reddanna
BACKGROUND: Aegle marmelos (Bilva) is being used in Ayurveda for the treatment of several inflammatory disorders. The plant is a member of a fixed dose combination of Dashamoola in Ayurveda. However, the usage of roots/root bark or stems is associated with sustainability concerns. OBJECTIVES: The present study is aimed to compare the anti-inflammatory properties of different extracts of young roots (year wise) and mature parts of Bilva plants collected from different geographical locations in India, so as to identify a sustainable source for Ayurvedic formulation...
November 24, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29237778/mpges1-dependent-prostaglandin-e2-pge2-controls-antigen-specific-th17-and-th1-responses-by-regulating-t-autocrine-and-paracrine-pge2-production
#16
Damian Maseda, Elizabeth M Johnson, Lindsay E Nyhoff, Bridgette Baron, Fumiaki Kojima, Ashley J Wilhelm, Martin R Ward, Jerold G Woodward, David D Brand, Leslie J Crofford
The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly PGE2, are critical molecules in the initiation and resolution of inflammation and in the transition from innate to acquired immune responses. Microsomal PGE synthase 1 (mPGES1) is an integral membrane enzyme whose regulated expression controls PGE2 levels and is highly expressed at sites of inflammation. PGE2 is also associated with modulation of autoimmunity through altering the IL-23/IL-17 axis and regulatory T cell (Treg) development...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29236491/short-chain-fatty-acids-suppress-inflammatory-reactions-in-caco-2-cells-and-mouse-colons
#17
Tran Van Hung, Takuya Suzuki
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, play an important role in the maintenance of intestinal homeostasis. In the present study, anti-inflammatory effects of SCFAs were examined in human intestinal Caco-2 cells and mouse colonic cultures. Stimulation of Caco-2 cells with tumor necrosis factor (TNF)-α induced interleukin (IL)-8 (TNF-α, 17.1 ± 7.2 vs Control, 1.00 ± 0.26, P < 0.01) and IL-6 expression (TNF-α, 21.7 ± 10.0 vs Control, 1.00 ± 0.28, P < 0.01) through the activation of nuclear factor κB p65, spleen tyrosine kinase, and mitogen-activated protein kinase pathways...
December 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29234390/astragaloside-iv-ameliorates-airway-inflammation-in-an-established-murine-model-of-asthma-by-inhibiting-the-mtorc1-signaling-pathway
#18
Hualiang Jin, Limin Wang, Bei Li, Cui Cai, Jian Ye, Junbo Xia, Shenglin Ma
Astragaloside IV (AS-IV), a main active constituent of Astragalus membranaceus, has been confirmed to have antiasthmatic effects. However, it remained unclear whether the beneficial effects of AS-IV on asthma were attributed to the mTOR inhibition; this issue was the focus of the present work. BALB/c mice were sensitized and challenged with ovalbumin followed with 3 weeks of rest/recovery and then reexposure to ovalbumin. AS-IV was administrated during the time of rest and reexposure. The characteristic features of allergic asthma, including airway hyperreactivity, histopathology, cytokines (IL-4, IL-5, IL-13, IL-17, and INF-γ), and CD4+CD25+Foxp3+Treg cells in bronchoalveolar lavage fluid (BALF), and downstream proteins of mTORC1/2 signaling were examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29233147/neutrophil-extracellular-traps-are-downregulated-by-glucocorticosteroids-in-lungs-in-an-equine-model-of-asthma
#19
Amandine Vargas, Roxane Boivin, Patricia Cano, Yoana Murcia, Isabelle Bazin, Jean-Pierre Lavoie
BACKGROUND: Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammation in asthma, and were found to be unaffected by GC in vitro. As IL-17 is overexpressed in neutrophilic asthma and contributes to steroid insensitivity in different cell types, we hypothesized that NETs formation in asthmatic airways would be resistant to GC through an IL-17 mediated pathway...
December 12, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29228446/telmisartan-reduces-arrhythmias-through-increasing-cardiac-connexin43-by-inhibiting-il-17-after-myocardial-infarction-in-rats
#20
H-Y Chang, X Li, Y Tian
OBJECTIVE: To observe the expressions of myocardial connexin43 (Cx43) and interleukin-17 (IL-17) in acute myocardial infarction (AMI) rats and investigate its possible mechanism of telmisartan in the prevention and treatment of arrhythmia in AMI. MATERIALS AND METHODS: Sprague Dawley (SD) rats were selected and myocardial infarction model was established. After the successful modeling, the rats were randomly divided into three groups: Sham group, MI group, Telm group...
November 2017: European Review for Medical and Pharmacological Sciences
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