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Johannes Betge, Ana Barat, Verena Murphy, Thomas Hielscher, Nicole C Van Grieken, Sebastian Belle, Tianzuo Zhan, Nicolai Härtel, Melanie Kripp, Orna Bacon, Martijn Cordes, Elaine W Kay, Henk M W Verheul, Maarten Neerincx, Bryan Hennessy, Ralf D Hofheinz, Timo Gaiser, Bauke Ylstra, Jochen H M Prehn, Diether Lambrechts, Annette T Byrne, Matthias P Ebert, Nadine Schulte
BACKGROUND/AIMS: This study is aimed at analyzing the survival rates and prognostic factors of stage IV colorectal cancer patients from 3 European cohorts undergoing combination chemotherapy with bevacizumab. METHODS: Progression free-survival (PFS) and overall survival (OS) were analyzed in 172 patients using the Kaplan-Meier method and uni- and multivariable Cox proportional hazards regression models. RESULTS: The median PFS was 9.7 and the median OS 27...
October 19, 2016: Digestion
Anupam Guleria, Avadhesh Pratap, Durgesh Dubey, Atul Rawat, Smriti Chaurasia, Edavalath Sukesh, Sanat Phatak, Sajal Ajmani, Umesh Kumar, Chunni Lal Khetrapal, Paul Bacon, Ramnath Misra, Dinesh Kumar
Management of patient with Lupus Nephritis (LN) continues to remain a challenge for the treating physicians because of considerable morbidity and even mortality. The search of biomarkers in serum and urine is a focus of researchers to unravel new targets for therapy. In the present study, the utility of NMR-based serum metabolomics has been evaluated for the first time in discriminating LN patients from non-nephritis lupus patients (SLE) and further to get new insights into the underlying disease processes for better clinical management...
October 14, 2016: Scientific Reports
E B Tapper, B R Bacon, M P Curry, D T Dieterich, S L Flamm, L E Guest, K V Kowdley, Y Lee, N C Tsai, Z M Younossi, N H Afdhal
Early data regarding the "real-world" experience with novel therapies for hepatitis C (HCV) are encouraging. Data are still limited, however, regarding real-world rates of sustained virologic response (SVR) for ledipasvir-sofosbuvir (LDV-SOF), particularly for patients with prior treatment failure. We performed a retrospective cohort study of 1597 patients with chronic genotype 1 HCV who were treated using 12 weeks of the following regimens LDV-SOF±ribavirin (RBV) (n=1521 without RBV, n=76 with RBV). The primary outcome was SVR-determined at 12 weeks in an intention-to-treat design...
October 11, 2016: Journal of Viral Hepatitis
Daniel Crow, Robert Joynt, M Saffman
Motivated by limitations and capabilities of neutral atom qubits, we examine whether measurement-free error correction can produce practical error thresholds. We show that this can be achieved by extracting redundant syndrome information, giving our procedure extra fault tolerance and eliminating the need for ancilla verification. The procedure is particularly favorable when multiqubit gates are available for the correction step. Simulations of the bit-flip, Bacon-Shor, and Steane codes indicate that coherent error correction can produce threshold error rates that are on the order of 10^{-3} to 10^{-4}-comparable with or better than measurement-based values, and much better than previous results for other coherent error correction schemes...
September 23, 2016: Physical Review Letters
Catherine J Bacon, Ngaire Kerse, Karen J Hayman, Simon A Moyes, Ruth O Teh, Mere Kepa, Avinesh Pillai, Lorna Dyall
BACKGROUND AND OBJECTIVES: This study assessed vitamin D status and its determinants in a cohort of octogenarians living within New Zealand's Bay of Plenty and Lakes Districts. METHODS AND STUDY DESIGN: Serum 25- hydroxyvitamin D [25(OH)D] concentration was measured in 209 Māori (aged 80-90 years) and 357 non-Māori (85 years), along with demographic, lifestyle, supplement use and other health data. RESULTS: Mean [95% CI] 25(OH)D concentration was 69 [67 to 72] nmol/L, with 15% >100 nmol/L and 6 individuals >150 nmol/L...
December 2016: Asia Pacific Journal of Clinical Nutrition
J Papp
In his five publications Nees (1811-1834) described 263 braconid species originating mainly from Germany and, less in number, from a further seven countries in Europe. The braconid species were assigned to 19 genera: twelve have been created by him and the rest (seven genera) by three other authors. The majority of the species (218) remained valid, the rest of the names (45) were placed in synonymy (by other authors). By his descriptions the species and genera are more or less recognizable, nevertheless their redescriptions are promoting their unambiguous recognition...
September 21, 2016: Zootaxa
Donald W Lee, Hung-Lun Hsu, Kaitlyn B Bacon, Susan Daniel
With the development of single-particle tracking (SPT) microscopy and host membrane mimics called supported lipid bilayers (SLBs), stochastic virus-membrane binding interactions can be studied in depth while maintaining control over host receptor type and concentration. However, several experimental design challenges and quantitative image analysis limitations prevent the widespread use of this approach. One main challenge of SPT studies is the low signal-to-noise ratio of SPT videos, which is sometimes inevitable due to small particle sizes, low quantum yield of fluorescent dyes, and photobleaching...
2016: PloS One
Brianan McGovern, Fiona Quinn, Clare Andrews, Michael Jeffers, Christopher L Bacon, Brian Bird, Gerard Crotty, Elisabeth Vandenberghe, Richard Flavin
No abstract text is available yet for this article.
August 11, 2016: Leukemia & Lymphoma
Roxanne Pelletier, Jin Choi, Nicholas Winters, Mark J Eisenberg, Simon L Bacon, Jafna Cox, Stella S Daskalopoulou, Kim L Lavoie, Igor Karp, Avi Shimony, Derek So, George Thanassoulis, Louise Pilote
BACKGROUND: Over past decades, the incidence of acute coronary syndrome (ACS) has increased in young women, and greater mortality rates after discharge were observed among young women vs men. We revisited this issue with contemporary data from the Gender and Sex Determinants of Cardiovascular Disease: From Bench to Beyond Premature Acute Coronary Syndrome (GENESIS-PRAXY), a multicentre prospective cohort study. METHODS: One thousand two hundred thirteen patients were enrolled in GENESIS-PRAXY from 26 centres across Canada, the United States, and Switzerland between January 2009 and April 2013...
September 21, 2016: Canadian Journal of Cardiology
Oscar Arrieta, Andrés F Cardona, Luis Corrales-Rodriguez, George Oblitas, Leonardo Rojas, Ludwing Bacon, Claudio Martin, Mauricio Cuello, Luis Mass, Beatriz Wills, Carlos Vargas, Hernán Carranza, Jorge Otero, María Angelina Pérez, Lisde González, Luis Chirinos, Rafael Rosell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Luis Corrales-Rodriguez, Andrés F Cardona, Oscar Arrieta, George Oblitas, Leonardo Rojas, Ludwing Bacon, Claudio Martin, Beatriz Wills, Mauricio Cuello, Luis Mass, Carlos Vargas, Hernán Carranza, Jorge Otero, María Angelina Pérez, Lisde González, Luis Chirinos, Rafael Rosell
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Luis Corrales-Rodriguez, Oscar Arrieta, Luis Mas, Omar O Castillo-Fernandez, Normand Blais, Claudio Martin, Ludwing Bacon, Allan Ramos-Esquivel, Mauricio Cuello, Leonardo Rojas, Melissa Juárez, Andrés F Cardona
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Oncology
Andreas U Lindner, Manuela Salvucci, Clare Morgan, Naser Monsefi, Alexa J Resler, Mattia Cremona, Sarah Curry, Sinead Toomey, Robert O'Byrne, Orna Bacon, Michael Stühler, Lorna Flanagan, Richard Wilson, Patrick G Johnston, Manuel Salto-Tellez, Sophie Camilleri-Broët, Deborah A McNamara, Elaine W Kay, Bryan T Hennessy, Pierre Laurent-Puig, Sandra Van Schaeybroeck, Jochen H M Prehn
OBJECTIVE: The mitochondrial apoptosis pathway is controlled by an interaction of multiple BCL-2 family proteins, and plays a key role in tumour progression and therapy responses. We assessed the prognostic potential of an experimentally validated, mathematical model of BCL-2 protein interactions (DR_MOMP) in patients with stage III colorectal cancer (CRC). DESIGN: Absolute protein levels of BCL-2 family proteins were determined in primary CRC tumours collected from n=128 resected and chemotherapy-treated patients with stage III CRC...
September 23, 2016: Gut
Manuela Salvucci, Maximilian L Würstle, Clare Morgan, Sarah Curry, Mattia Cremona, Andreas U Lindner, Orna Bacon, Alexa J Resler, Aine C Murphy, Robert O'Byrne, Lorna Flanagan, Sonali Dasgupta, Nadege Rice, Camilla Pilati, Elisabeth Zink, Lisa M Schöller, Sinead Toomey, Mark Lawler, Patrick G Johnston, Richard H Wilson, Sophie Camilleri-Broët, Manuel Salto-Tellez, Deborah A McNamara, Elaine W Kay, Pierre Laurent-Puig, Sandra Van Schaeybroeck, Bryan T Hennessy, Daniel B Longley, Markus Rehm, Jochen Hm Prehn
PURPOSE: Apoptosis is essential for chemotherapy responses. In this discovery and validation study, we evaluated the suitability of a mathematical model of apoptosis execution (APOPTO-CELL) as a stand-alone signature and as a constituent of further refined prognostic stratification tools. EXPERIMENTAL DESIGN: Apoptosis competency of primary tumor samples from n=120 stage III colorectal cancer patients was calculated by APOPTO-CELL from measured protein concentrations of Procaspase-3, Procaspase-9, SMAC and XIAP...
September 20, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Sherif A El-Nashar, Ruchira Singh, Melissa M Bacon, Shunaha Kim-Fine, John A Occhino, John B Gebhart, Christopher J Klingele
INTRODUCTION AND HYPOTHESIS: To report on clinical presentation, diagnosis, and outcomes after treatment of female urethral diverticulum (UD). METHODS: Using a record linkage system, women with a new diagnosis of UD at Mayo Clinic from January 1, 1980, through December 31, 2011, were identified. The presenting symptoms, clinical characteristics, diagnosis, and management of women presenting with UD were recorded. Outcomes after surgery were assessed using survival analysis...
September 16, 2016: Female Pelvic Medicine & Reconstructive Surgery
Joseph L Goldstein
For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of art's three-panel triptych, a form that the modern master Francis Bacon used to distill complex stories in a bold way.
September 22, 2016: Cell
Gail C Hanson, Bruce Jones, Catherine J Bacon, Robert W Moran
To explore clinical changes following a novel manual mobilisation technique, 24 participants who experienced 'moderate' to 'severe' chronic low back pain were recruited from new patients attending a suburban osteopathy clinic. The intervention was a previously undescribed side-lying mobilisation technique targeting the lumbosacral spine (median of 6 treatment sessions). After 8 weeks reductions were shown in Oswestry Disability Index of 15 points (95% CI: 9.3, 22.7; p < 0.0001 for overall ANOVA); Quadruple Visual Analogue Scale of 2...
July 2016: Journal of Bodywork and Movement Therapies
Rachel S Johnson, Mia K Provenzano, Larynn M Shumaker, Tamara C Valovich-McLeod, Cailee E Welch Bacon
No abstract text is available yet for this article.
August 24, 2016: Journal of Sport Rehabilitation
Krista M Hixson, Hannah B Horris, Tamara C Valovich McLeod, Cailee E Welch Bacon
No abstract text is available yet for this article.
August 24, 2016: Journal of Sport Rehabilitation
Alexandre Antonelli, Hannes Hettling, Fabien L Condamine, Karin Vos, R Henrik Nilsson, Michael J Sanderson, Hervé Sauquet, Ruud Scharn, Daniele Silvestro, Mats Töpel, Christine D Bacon, Bengt Oxelman, Rutger A Vos
Rapidly growing biological data-including molecular sequences and fossils-hold an unprecedented potential to reveal how evolutionary processes generate and maintain biodiversity. However, researchers often have to develop their own idiosyncratic workflows to integrate and analyze these data for reconstructing time-calibrated phylogenies. In addition, divergence times estimated under different methods and assumptions, and based on data of various quality and reliability, should not be combined without proper correction...
September 10, 2016: Systematic Biology
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