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https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#1
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28910138/hsp90-inhibition-and-cellular-stress-elicits-phenotypic-plasticity-in-hematopoietic-differentiation
#2
Abdalla A Lawag, Jennifer M Napper, Caroline A Hunter, Nickolas A Bacon, Seth Deskins, Manaf El-Hamdani, Sarah-Leigh Govender, Emine C Koc, Vincent E Sollars
Cancer cells exist in a state of Darwinian selection using mechanisms that produce changes in gene expression through genetic and epigenetic alteration to facilitate their survival. Cellular plasticity, or the ability to alter cellular phenotype, can assist in survival of premalignant cells as they progress to full malignancy by providing another mechanism of adaptation. The connection between cellular stress and the progression of cancer has been established, although the details of the mechanisms have yet to be fully elucidated...
September 14, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28901709/exploring-subjectivity-in-competency-based-assessment-judgements-of-assessors
#3
Rachel Bacon, Kay Holmes, Claire Palermo
AIM: The aim of this research was to measure variations in assessors' judgements of a student dietitian's performance and to explore the influence of group discussion on their judgements. METHODS: The assessments of a student's performance, as observed from a video recording of an authentic nutrition consultation, were measured pre- and post-group discussion by 26 experienced assessors using a mixed-methods questionnaire. The instrument included a validated 7-point visual analogue scale (VAS) rating (1 = novice; 7 = competent), a qualitative global description of performance and an assessor's confidence rating (1 = not at all confident; 10 = extremely confident)...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28876140/school-nurses-perceptions-and-experiences-with-an-interprofessional-concussion-management-team-in-the-secondary-school-setting
#4
Cailee E Welch Bacon, Casey D Erickson, Melissa C Kay, Michelle L Weber, Tamara C Valovich McLeod
Following a concussion, both cognitive and physical rest are imperative aspects of injury management. The inclusion of academic adjustments and the formation of an interprofessional concussion management team (ICMT) provide a mechanism to manage academic issues following a concussion. As one of the sole healthcare providers presents during school hours, the school nurse may offer unique insight regarding the infrastructure of an ICMT in the secondary school setting. The purpose of this study was to explore school nurses' perceptions of and experiences with an ICMT for adolescents following a concussion in the secondary school setting...
September 6, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28867084/the-contribution-of-processed-pork-meat-products-to-total-salt-intake-in-the-diet
#5
Beulah Pretorius, Hettie C Schönfeldt
Consumption of processed meats is reported to be the second largest contributor to total dietary sodium intake. This study aims to describe the contribution of commonly consumed processed pork products to total salt intake. A large variation was found in the sodium content between similar products. Sodium content (mg/100g) for bacon ranged from 558 to 1570, russians from 762 to 1403, viennas from 480 to 1340 and ham from 696 to 1360 respectively. When converting sodium content from 100g to serving size, different products contributed the most sodium to the diet...
January 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28859110/junk-food-diet-induced-obesity-increases-d2-receptor-autoinhibition-in-the-ventral-tegmental-area-and-reduces-ethanol-drinking
#6
Jason B Cook, Linzy M Hendrickson, Grant M Garwood, Kelsey M Toungate, Christina V Nania, Hitoshi Morikawa
Similar to drugs of abuse, the hedonic value of food is mediated, at least in part, by the mesostriatal dopamine (DA) system. Prolonged intake of either high calorie diets or drugs of abuse both lead to a blunting of the DA system. Most studies have focused on DAergic alterations in the striatum, but little is known about the effects of high calorie diets on ventral tegmental area (VTA) DA neurons. Since high calorie diets produce addictive-like DAergic adaptations, it is possible these diets may increase addiction susceptibility...
2017: PloS One
https://www.readbyqxmd.com/read/28859006/nurses-to-their-nurse-leaders-we-need-your-help-after-a-failure-to-rescue-patient-death
#7
Cynthia Thornton Bacon
The purpose of this study was to describe nurses' needs and how they are being met and not met after caring for surgical patients who died after a failure to rescue (FTR). A qualitative, phenomenologic approach was used for the interview and analysis framework. Methods to ensure rigor and trustworthiness were incorporated into the design. The investigator conducted semistructured 1:1 interviews with 14 nurses. Data were analyzed using Colaizzi's methods. Four themes were identified: (1) coping mechanisms are important; (2) immediate peer and supervisor feedback and support are needed for successful coping; (3) subsequent supervisor support is crucial to moving on; and (4) nurses desire both immediate support and subsequent follow-up from their nurse leaders after every FTR death...
October 2017: Nursing Administration Quarterly
https://www.readbyqxmd.com/read/28857639/what-helps-in-self-help-a-qualitative-exploration-of-interactions-within-a-borderline-personality-disorder-self-help-group
#8
Briony Bond, John Wright, Alison Bacon
BACKGROUND: Self-help groups can have a large impact on individuals well-being and could reduce costs for healthcare services. Previous research supports the effectiveness of self-help groups, but explanations for this are lacking. Identifying the active ingredients which encourage positive change could inform effectiveness of these groups producing the best outcomes for members. AIM: This research investigated how members and facilitators of a borderline personality disorder self-help group (BPD SHG) interacted and made sense of their experiences in group meetings, to determine what aspects of interaction were helpful...
August 31, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28818518/seladelpar-mbx-8025-a-selective-ppar-%C3%AE-agonist-in-patients-with-primary-biliary-cholangitis-with-an-inadequate-response-to-ursodeoxycholic-acid-a-double-blind-randomised-placebo-controlled-phase-2-proof-of-concept-study
#9
David Jones, Pol F Boudes, Mark G Swain, Christopher L Bowlus, Michael R Galambos, Bruce R Bacon, Yvonne Doerffel, Norman Gitlin, Stuart C Gordon, Joseph A Odin, David Sheridan, Markus-Alexander Wörns, Virginia Clark, Linsey Corless, Heinz Hartmann, Mark E Jonas, Andreas E Kremer, George F Mells, Peter Buggisch, Bradley L Freilich, Cynthia Levy, John M Vierling, David E Bernstein, Marek Hartleb, Ewa Janczewska, Fedja Rochling, Hemant Shah, Mitchell L Shiffman, John H Smith, Yun-Jung Choi, Alexandra Steinberg, Monika Varga, Harinder Chera, Robert Martin, Charles A McWherter, Gideon M Hirschfield
BACKGROUND: Many patients with primary biliary cholangitis have an inadequate response to first-line therapy with ursodeoxycholic acid. Seladelpar is a potent, selective agonist for the peroxisome proliferator-activated receptor-delta (PPAR-δ), which is implicated in bile acid homoeostasis. This first-in-class study evaluated the anti-cholestatic effects and safety of seladelpar in patients with an inadequate response to ursodeoxycholic acid. METHODS: The study was a 12-week, double-blind, placebo-controlled, phase 2 trial of patients with alkaline phosphatase of at least 1·67 times the upper limit of normal (ULN) despite treatment with ursodeoxycholic acid...
August 14, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28812096/perceived-racism-and-incident-diabetes-in-the-black-women-s-health-study
#10
Kathryn L Bacon, Sherri O Stuver, Yvette C Cozier, Julie R Palmer, Lynn Rosenberg, Edward A Ruiz-Narváez
AIMS/HYPOTHESIS: Our aim was to assess the association of perceived racism with type 2 diabetes, and the possible mediating influence of diet and BMI. METHODS: The Black Women's Health Study, a follow-up of 59,000 African-American women, began in 1995. Over 16 years 5344 incident cases of diabetes occurred during 576,577 person-years. Cox proportional hazards models were used to estimated HRs and 95% CIs for categories of 'everyday racism' (interpersonal racism in daily life) and 'lifetime racism' (reporting ever treated unfairly due to race with respect to police, housing or work) and incident type 2 diabetes...
August 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28811840/francis-bacon-and-his-invisible-rooms-human-emotions-so-felt-but-not-so-easily-seen
#11
Francesco Carelli
No abstract text is available yet for this article.
July 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28803559/rethinking-the-idea-of-late-autism-spectrum-disorder-onset
#12
Elizabeth C Bacon, Eric Courchesne, Cynthia Carter Barnes, Debra Cha, Sunny Pence, Laura Schreibman, Aubyn C Stahmer, Karen Pierce
A common theory of autism spectrum disorder (ASD) symptom onset includes toddlers who do not display symptoms until well after age 2, which are termed late-onset ASD cases. Objectives were to analyze differences in clinical phenotype between toddlers identified as ASD at initial evaluations (early diagnosed) versus those initially considered nonspectrum, then later identified as ASD (late diagnosed). Two hundred seventy-three toddlers recruited from the general population based on a failed developmental screening form or parent or physician concerns were followed longitudinally from 12 months and identified as early- and late-diagnosed cases of ASD, language delayed, or typically developing...
August 14, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28801851/vertical-distribution-of-soil-extractable-organic-c-and-n-contents-and-total-c-and-n-stocks-in-78-year-old-tree-plantations-in-subtropical-australia
#13
Xiaoqi Zhou, Haibo Dong, Zhongming Lan, Gary Bacon, Yanbin Hao, Chengrong Chen
Few studies have focused on the effects of long-term forest plantations on the soil profile of carbon (C) and nitrogen (N) stocks. In this study, we selected 78-year-old tree plantations that included three coniferous tree species (i.e., slash pine, hoop pine and kauri pine) and a Eucalyptus species in subtropical Australia. We measured soil extractable organic C (EOC) and N (EON) contents and total C and N stocks under different tree species on the forest floor and along a soil profile to 100 cm depth. The results showed that Eucalyptus had significantly higher soil EOC contents (3...
August 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28796530/athletic-trainers-roles-and-responsibilities-regarding-academic-adjustments-as-part-of-the-concussion-management-process-in-the-secondary-school-setting
#14
Cailee E Welch Bacon, Melissa C Kay, Tamara C Valovich McLeod
CONTEXT:   Athletic trainers (ATs) play a vital role in managing the care of student-athletes after a sport-related concussion, yet little is known about their specific involvement in the implementation of academic adjustments as part of the concussion-management plan. OBJECTIVE:   To explore ATs' perceived roles and responsibilities regarding the implementation of academic adjustments for concussed student-athletes. DESIGN:   Qualitative study...
August 10, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28764067/effect-of-flavourzyme-on-proteolysis-antioxidant-activity-and-sensory-qualities-of-cantonese-bacon
#15
Siyu Zhang, Chaoyang Zhang, Yan Qiao, Lujuan Xing, Dacheng Kang, Iftikhar Ali Khan, Ming Huang, Guanghong Zhou
The aim of this study was to investigate the influence of Flavourzyme on protein degradation, antioxidant activity and sensory qualities of Cantonese bacon made at 60°C for 28h. Flavourzyme was used at doses of 8, 16, 24, 32 and 40LAUP/kg of raw meat. Results indicated that Flavourzyme addition in Cantonese bacon promoted proteolysis, which was reflected by the increase of various free amino acids and SDS-PAGE-detected changes in the myogen and myofibrillar proteins. Sensory qualities were improved while TPA (texture profile analysis) was decreased significantly (P<0...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28764028/sensory-evaluation-of-boar-meat-products-by-trained-experts
#16
Jella Wauters, Kaat Verplanken, Vicky Vercruysse, Bart Ampe, Marijke Aluwé, Lynn Vanhaecke
Rearing entire male pigs, one of the alternatives for surgical castration, entails the possible occurrence of boar taint. This study aimed at the investigation of the acceptability of meat from entire male pigs in 8 different meat products (cutlets, bacon, blade loin, tenderloin, dry fermented sausage, cooked ham, dry-cured ham and minced meat) by trained assessors. Generally, the sensory evaluation of meat samples was affected the most in the androstenone (AEON) group, indicating that AEON is the most offensive boar taint compound for sensitive assessors...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28758989/corrigendum-palaeo-leaf-economics-reveal-a-shift-in-ecosystem-function-associated-with-the-end-triassic-mass-extinction-event
#17
W K Soh, I J Wright, K L Bacon, T I Lenz, M Steinthorsdottir, A C Parnell, J C McElwain
This corrects the article DOI: 10.1038/nplants.2017.104.
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28757485/francis-bacon-s-i-valerius-terminus-i-and-the-voyage-to-the-great-instauration
#18
Richard Serjeantson
Francis Bacon's earliest surviving natural philosophical treatise (composed circa 1603) bears the title Valerius Terminus of the Interpretation of Nature. This study, resting on fresh attention to the surviving authorial manuscript, has three goals. It begins by identifying a lost precursor work apparently entitled "Of Active Knowledge." It then examines the significance of the pseudonyms Bacon chose to introduce his ideas, considering especially his invocation of Erasmus's emblem, the Roman deity Terminus...
2017: Journal of the History of Ideas
https://www.readbyqxmd.com/read/28749581/prediction-of-transporter-mediated-drug-drug-interactions-for-baricitinib
#19
Maria M Posada, Ellen A Cannady, Christopher D Payne, Xin Zhang, James A Bacon, Y Anne Pak, J William Higgins, Nazila Shahri, Stephen D Hall, Kathleen M Hillgren
Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic and renal uptake and efflux drug transporters, based on the ratio of the unbound maximum eliminating-organ inlet concentration and the in vitro half-maximal inhibitory concentrations (IC50 ). In vitro, baricitinib was a substrate for organic anion transporter (OAT)3, multidrug and toxin extrusion protein (MATE)2-K, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP)...
July 27, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28715459/efficacy-of-abdominal-acupuncture-for-neck-pain-a-randomized-controlled-trial
#20
Lai Fun Ho, Zhi Xiu Lin, Albert Wing Nang Leung, Liyi Chen, Hongwei Zhang, Bacon Fung Leung Ng, Eric Tat Chi Ziea, Yuanqi Guo
OBJECTIVE: This study aims to provide evidence regarding the clinical efficacy of abdominal acupuncture for neck pain. METHODS: This randomized, patient and assessor-blind, sham-controlled trial was conducted at a Chinese medicine center in Hong Kong between November 2014 and March 2016. A total of 154 eligible participants (age range, 18-65 years) with neck pain were randomly assigned to receive abdominal (n = 77) or non-penetrating sham abdominal (sham group; n = 77) acupuncture...
2017: PloS One
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