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immune deficiency category 2

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This policy statement provides recommendations for the prevention of serogroup B meningococcal disease through the use of 2 newly licensed serogroup B meningococcal vaccines: MenB-FHbp (Trumenba; Wyeth Pharmaceuticals, a subsidiary of Pfizer, Philadelphia, PA) and MenB-4C (Bexsero; Novartis Vaccines, Siena, Italy). Both vaccines are approved for use in persons 10 through 25 years of age. MenB-FHbp is licensed as a 2- or 3-dose series, and MenB-4C is licensed as a 2-dose series for all groups. Either vaccine is recommended for routine use in persons 10 years and older who are at increased risk of serogroup B meningococcal disease (category A recommendation)...
September 2016: Pediatrics
Ida Hafstrand, Elien M Doorduijn, Adil Doganay Duru, Jeremie Buratto, Claudia Cunha Oliveira, Tatyana Sandalova, Thorbald van Hall, Adnane Achour
MHC class I downregulation represents a significant challenge for successful T cell-based immunotherapy. T cell epitopes associated with impaired peptide processing (TEIPP) constitute a novel category of immunogenic Ags that are selectively presented on transporter associated with Ag processing-deficient cells. The TEIPP neoepitopes are CD8 T cell targets, derived from nonmutated self-proteins that might be exploited to prevent immune escape. In this study, the crystal structure of H-2D(b) in complex with the first identified TEIPP Ag (MCLRMTAVM) derived from the Trh4 protein has been determined to 2...
March 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Yalemzewod Assefa Gelaw, Goitom Halefom Senbete, Akelew Awoke Adane, Kefyalew Addis Alene
BACKGROUND: Late diagnosis and presentation to human immune deficiency virus (HIV)/acquired immune deficiency syndrome care reduce the benefits of antiretroviral therapy and increase the risk of HIV transmission. OBJECTIVES: This study was conducted to identify determinants of late presentation to HIV care among people living with HIV in Southern Tigray, Northern Ethiopia. METHODS: An institution based un-matched case-control (1:2 ratios) supported with qualitative data was conducted in Southern Tigray Zone from March 1 to April 30, 2014...
2015: AIDS Research and Therapy
Fethi Mellouli, Imen Ben Mustapha, Monia Ben Khaled, Habib Besbes, Monia Ouederni, Najla Mekki, Meriem Ben Ali, Beya Larguèche, Mongia Hachicha, Tahar Sfar, Neji Gueddiche, Siheme Barsaoui, Azza Sammoud, Khadija Boussetta, Saida Ben Becher, Ahmed Meherzi, Najoua Guandoura, Lamia Boughammoura, Abdelaziz Harbi, Fethi Amri, Fethi Bayoudh, Najla Ben Jaballah, Neji Tebib, Asma Bouaziz, Abdelmajid Mahfoudh, Hajer Aloulou, Lamia Ben Mansour, Imen Chabchoub, Raoudha Boussoffara, Jalel Chemli, Jihène Bouguila, Saida Hassayoun, Saber Hammami, Zakia Habboul, Agnès Hamzaoui, Jamel Ammar, Mohamed-Ridha Barbouche, Mohamed Bejaoui
PURPOSE: Primary immunodeficiencies (PIDs) are a large group of diseases characterized by susceptibility to not only recurrent infections but also autoimmune diseases and malignancies. The aim of this study was to describe and analyze the distribution, clinical features and eventual outcome of PID among Tunisian patients. METHODS: We reviewed the record of 710 patients diagnosed with Primary Immunodeficiency Diseases (PIDs) from the registry of the Tunisian Referral Centre for PIDs over a 25-year period...
November 2015: Journal of Clinical Immunology
Beatriz E Ramírez, Ana Sánchez, José M Herreras, Itziar Fernández, Javier García-Sancho, Teresa Nieto-Miguel, Margarita Calonge
OBJECTIVE: To evaluate outcomes of cultivated limbal epithelial transplantation (CLET) for management of ocular surface failure due to limbal stem cell deficiency (LSCD). DESIGN: Prospective, noncomparative, interventional case series and extensive comparison with recent similar studies. PARTICIPANTS: Twenty eyes with LSCD underwent CLET (11 autologous; 9 allogeneic) and were followed up for 3 years. Etiologies were divided into 3 prognostic categories: Group 1, chemical injuries (7 eyes); Group 2, immune-based inflammation (4 eyes); and Group 3, noninflammatory diseases (9 eyes)...
2015: BioMed Research International
E Wahome, L Makori, M Gikera, J Wafula, J Chakaya, M E Edginton, A M V Kumar
SETTING: Kenyatta National Hospital (KNH), Nairobi, Ken-ya, a large referral and teaching hospital. OBJECTIVE: 1) To document tuberculosis (TB) case notification rates and trends; 2) to describe demographic, clinical and workplace characteristics and treatment outcomes; and 3) to examine associations between demographic and clinical characteristics, HIV/AIDS (human immunodeficiency virus/acquired immune-deficiency syndrome) treatment and anti-tuberculosis treatment outcomes among hospital workers with TB at KNH during the period 2006-2011...
December 21, 2013: Public Health Action
Rebeca Pérez de Diego, Silvia Sánchez-Ramón, Eduardo López-Collazo, Rubén Martínez-Barricarte, Carolina Cubillos-Zapata, Antonio Ferreira Cerdán, Jean-Laurent Casanova, Anne Puel
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1). These 3 CARD-BCL10-MALT1 (CBM) complexes activate nuclear factor κB in both the innate and adaptive arms of immunity. Human inherited defects of the 3 components of the CBM complex, including the 2 adaptors CARD9 and CARD11 and the 2 core components BCL10 and MALT1, have recently been reported...
November 2015: Journal of Allergy and Clinical Immunology
Chandra L Ford, Dionne C Godette, Mesfin S Mulatu, Tommi L Gaines
BACKGROUND: Although routine human immune deficiency virus (HIV) testing during health care visits is recommended for most adults, many older adults (i.e., ages 50-64 years) do not receive it. This study identified factors associated with HIV testing in the past 12 months (i.e., recent HIV testing) among US adults in the 3 categories of older adulthood (50-54, 55-59, and 60-64 years) for which routine HIV testing is recommended. METHOD: This was a cross-sectional analysis of data from US older adult respondents to the 2010 Behavioral Risk Factor Surveillance System...
August 2015: Sexually Transmitted Diseases
Fanny Le Du, Bedrich L Eckhardt, Bora Lim, Jennifer K Litton, Stacy Moulder, Funda Meric-Bernstam, Ana M Gonzalez-Angulo, Naoto T Ueno
Significant research has been conducted to better understand the extensive, heterogeneous molecular features of triple-negative breast cancer (TNBC). We reviewed published TNBC molecular classifications to identify major groupings that have potential for clinical trial development. With the ultimate aim to streamline translational medicine, we linked these categories of TNBC according to their gene-expression signatures, biological function, and clinical outcome. To this end, we define five potential clinically actionable groupings of TNBC: 1) basal-like TNBC with DNA-repair deficiency or growth factor pathways; 2) mesenchymal-like TNBC with epithelial-to-mesenchymal transition and cancer stem cell features; 3) immune-associated TNBC; 4) luminal/apocrine TNBC with androgen-receptor overexpression; and 5) HER2-enriched TNBC...
May 30, 2015: Oncotarget
J R Macho, W P Schecter
In 1993, it is estimated that 2 million Americans are infected with the human Immunodeficiency Virus (HIV). The Acquired Immune Deficiency Syndrome (AIDS) represents the most severe manifestation of infection with the virus. In the patient with AIDS, helper T lymphocytes are depleted resulting in a defect in cell mediated immunity. The resulting state of profound immunosuppression leads to susceptibility to rare infections and tumors. Although opportunistic infections have been seen in patients on immunosuppressive therapy, those associated with AIDS are much more severe and extensive...
October 1993: Surgical Technology International
Pragna Patel, Carl Armon, Joan S Chmiel, John T Brooks, Kate Buchacz, Kathy Wood, Richard M Novak
BACKGROUND: Little is known about survival and factors associated with mortality after cancer diagnosis among persons infected with human immunodeficiency virus (HIV). METHODS: Using Poisson regression, we analyzed incidence rates of acquired immune deficiency syndrome (AIDS)-defining cancers (ADC), non-AIDS-defining infection-related cancers (NADCI), and non-AIDS-defining noninfection-related cancers (NADCNI) among HIV Outpatient Study participants seen at least twice from 1996-2010...
March 2014: Open Forum Infectious Diseases
B M Jonkman-Berk, J M van den Berg, I J M Ten Berge, R G M Bredius, G J Driessen, V A S H Dalm, J T van Dissel, M van Deuren, P M Ellerbroek, M van der Flier, P M van Hagen, J M van Montfrans, A Rutgers, E H Schölvinck, E de Vries, R T van Beem, T W Kuijpers
PURPOSE: To analyze the data of the national registry of all Dutch primary immune deficiency (PID) patients, according to the European Society for Immunodeficiencies (ESID) definitions. RESULTS: In the Netherlands, 745 patients had been registered between 2009 and 2012. An overall prevalence of 4.0 per 100,000 inhabitants was calculated. The most prevalent PID was 'predominantly antibody disorder (PAD)' (60.4%). In total, 118 transplantations were reported, mostly hematopoietic stem cell transplantations (HSCT)...
February 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Peter A Minchella, Simon Donkor, Olumuyiwa Owolabi, Jayne S Sutherland, Joann M McDermid
BACKGROUND: Anemia is common in tuberculosis, and multiple etiologies necessitate targeted interventions. The proportion of iron-responsive anemia due to iron deficiency compared with iron-unresponsive anemia due to impaired iron absorption/redistribution from tuberculosis-associated immune activation or inflammation is unknown. This impedes selection of safe and effective treatment and appropriate intervention timing. METHODS: Baseline hemoglobin, ferritin, hepcidin, soluble transferrin receptor (sTfR), and transferrin were measured in 45 patients with confirmed pulmonary tuberculosis (cases), 47 tuberculin skin test (TST)-positive controls, and 39 TST-negative controls in The Gambia...
March 1, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster
The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein Zfp335. Zfp335(bloto/bloto) mice exhibit a naïve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery, affecting T cells that have recently undergone thymic egress. The effects of Zfp335(bloto) are multigenic and cannot be attributed to altered thymic selection, proliferation or Bcl2-dependent survival...
2014: ELife
Amare Eshetu, Aster Tsegaye, Beyene Petros
Poor micronutrient levels are associated with an increased risk of progression to AIDS and are also suggested to influence outcome of highly active antiretroviral therapy (HAART), though existing data are inconclusive to support the latter. Few published data are available on micronutrient levels in Ethiopian HIV/AIDS patients taking HAART. The objective of the study was to determine the association of micronutrient levels and response to HAART (CD4(+) T cell count) among adult HIV/AIDS patients attending a teaching Hospital in Addis Ababa...
December 2014: Biological Trace Element Research
Kenneth M Kaufman, Bolan Linghu, Joseph D Szustakowski, Ammar Husami, Fan Yang, Kejian Zhang, Alexandra H Filipovich, Ndate Fall, John B Harley, N R Nirmala, Alexei A Grom
OBJECTIVE: Macrophage activation syndrome (MAS), a life-threatening complication of systemic juvenile idiopathic arthritis (JIA), resembles familial hemophagocytic lymphohistiocytosis (HLH), a constellation of autosomal-recessive immune disorders resulting from deficiency in cytolytic pathway proteins. We undertook this study to test our hypothesis that MAS predisposition in systemic JIA could be attributed to rare gene sequence variants affecting the cytotolytic pathway. METHODS: Whole-exome sequencing was used in 14 patients with systemic JIA and MAS and in their parents to identify protein-altering single-nucleotide polymorphisms/indels in known HLH-associated genes...
December 2014: Arthritis & Rheumatology
Marie Helleberg, Jan Gerstoft, Shoaib Afzal, Gitte Kronborg, Carsten S Larsen, Court Pedersen, Stig E Bojesen, Børge G Nordestgaard, Niels Obel
BACKGROUND: The relative impact of immune deficiency and lifestyle-related factors on risk of cancer in the HIV-infected population is controversial. We aimed to estimate the population-attributable fractions (PAFs) associated with smoking, being HIV-infected and with immune deficiency. METHODS: In a Danish, nationwide, population-based cohort study (1995-2011), incidences of cancer were compared between an HIV-infected cohort and a population-based matched cohort in analyses stratified on cancer category, smoking status and for HIV patients: low CD4 cell count...
June 19, 2014: AIDS
Wong Kuen Alencar, Paulo Schiavom Duarte, Eliseu Alves Waldman
INTRODUCTION: Survival of patients with acquired immune deficiency syndrome has improved with combination antiretroviral therapy; mortality due to liver diseases, however, has also increased in these patients. OBJECTIVES: To estimate the accumulated probability of survival in human immunodeficiency virus-hepatitis C virus coinfected and non-coinfected patients and to investigate factors related to acquired immune deficiency syndrome patients' survival. METHODS: Non-concurrent cohort study using data from surveillance information systems of acquired immune deficiency syndrome patients over 13 years of age...
March 2014: Brazilian Journal of Infectious Diseases
Ernest A Tako, Maryam F Hassimi, Erqiu Li, Steven M Singer
UNLABELLED: The immune system has numerous mechanisms that it can use to combat pathogens and eliminate infections. Nevertheless, studies of immune responses often focus on single pathways required for protective responses. We applied microarray analysis of RNA in order to investigate the types of immune responses produced against infection with the intestinal pathogen Giardia duodenalis. Infection with G. duodenalis is one of the most common causes of diarrheal disease in the world. While several potential antiparasitic effector mechanisms, including complement lysis, nitric oxide (NO), and α-defensin peptides, have been shown to inhibit parasite growth or kill Giardia in vitro, studies in vivo have thus far shown clear roles only for antibody and mast cell responses in parasite control...
2013: MBio
Daniel Ness, Zhao Ren, Shyra Gardai, Douglas Sharpnack, Victor J Johnson, Richard J Brennan, Elizabeth F Brigham, Andrew J Olaharski
Genetic evidence links mutations in the LRRK2 gene with an increased risk of Parkinson's disease, for which no neuroprotective or neurorestorative therapies currently exist. While the role of LRRK2 in normal cellular function has yet to be fully described, evidence suggests involvement with immune and kidney functions. A comparative study of LRRK2-deficient and wild type rats investigated the influence that this gene has on the phenotype of these rats. Significant weight gain in the LRRK2 null rats was observed and was accompanied by significant increases in insulin and insulin-like growth factors...
2013: PloS One
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