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Human menopausal gonadotropin

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https://www.readbyqxmd.com/read/27922279/clinical-experience-with-an-ovarian-stimulation-protocol-for-intrauterine-insemination-adopting-a-gonadotropin-releasing-hormone-antagonist-at-low-dose
#1
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation (COS) for intrauterine insemination (IUI) have provided controversial results. The present study was undertaken to evaluate, whether the use of a half of the conventional dose of the GnRH antagonist cetrorelix can be effective in increasing the successful rate of IUI cycles. Patients started COS with human menopausal gonadotropin (hMG) on day three of the menstrual cycle. Cetrorelix was started when at least one follicle of ≥14 mm, was detected at the ultrasound scan, according to the flexible multiple daily dose protocol, and continued until the trigger day with recombinant hCG...
December 6, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27847314/luteinizing-hormone-acts-at-the-hippocampus-to-dampen-spatial-memory
#2
Veronica Burnham, Christopher Sundby, Abigail Laman-Maharg, Janice Thornton
Luteinizing hormone (LH) rises dramatically during and after menopause, and has been correlated with an increased incidence of Alzheimer's disease and decreased memory performance in humans and animal models. To test whether LH acts directly on the dorsal hippocampus to affect memory, ovariectomized female rats were infused with either the LH-homologue human chorionic gonadotropin (hCG) or the LH receptor antagonist deglycosylated-hCG (dg-hCG).Infusion of hCG into either the lateral ventricle or the dorsal hippocampus caused significant memory impairments in ovariectomized estradiol-treated females...
November 12, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27499598/complete-molar-pregnancy-in-postmenopausal-women
#3
Jasmina Begum, Pallavee Palai, Seetesh Ghose
Gestational trophoblastic disease (GTD) is an abnormal proliferation of trophoblastic tissue during pregnancy. It is a disease of reproductive age, and a few cases have also been seen in women with advanced age, although it is extremely rare in postmenopausal women. Here, we describe an uncommon case of complete hydatidiform mole (CHM) in a postmenopausal woman, who has presented to us with complaints of bleeding per vagina, vomiting with 22 weeks size gravid uterus. Ultrasound finding along with raised serum beta-human chorionic gonadotropin (β-HCG) 400,000 mIU/ml suggested the diagnosis of CHM...
April 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27457513/eular-recommendations-for-women-s-health-and-the-management-of-family-planning-assisted-reproduction-pregnancy-and-menopause-in-patients-with-systemic-lupus-erythematosus-and-or-antiphospholipid-syndrome
#4
L Andreoli, G K Bertsias, N Agmon-Levin, S Brown, R Cervera, N Costedoat-Chalumeau, A Doria, R Fischer-Betz, F Forger, M F Moraes-Fontes, M Khamashta, J King, A Lojacono, F Marchiori, P L Meroni, M Mosca, M Motta, M Ostensen, C Pamfil, L Raio, M Schneider, E Svenungsson, M Tektonidou, S Yavuz, D Boumpas, A Tincani
OBJECTIVES: Develop recommendations for women's health issues and family planning in systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). METHODS: Systematic review of evidence followed by modified Delphi method to compile questions, elicit expert opinions and reach consensus. RESULTS: Family planning should be discussed as early as possible after diagnosis. Most women can have successful pregnancies and measures can be taken to reduce the risks of adverse maternal or fetal outcomes...
July 25, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27428219/the-utrogestan-and-hmg-protocol-in-patients-with-polycystic-ovarian-syndrome-undergoing-controlled-ovarian-hyperstimulation-during-ivf-icsi-treatments
#5
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
Poor oocyte quality is a main concern for decreased reproductive outcomes in women with polycystic ovarian syndrome (PCOS) during controlled ovarian hyperstimulation (COH). A primary way to improve oocyte quality is to optimize the COH protocol. It was demonstrated that the viable embryo rate per oocyte retrieved in the Utrogestan and hMG protocol, a novel regimen based on frozen-thawed embryo transfer (FET), is statistically higher than that in the short protocol. Thus, a retrospective study was conducted to evaluate the endocrine characteristics and clinical outcomes in PCOS patients subjected to the Utrogestan and hMG protocol compared with those subjected to the short protocol...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27385972/comparison-pregnancy-outcomes-between-minimal-stimulation-protocol-and-conventional-gnrh-antagonist-protocols-in-poor-ovarian-responders
#6
Shamim Pilehvari, Ensieh ShahrokhTehraninejad, Batool Hosseinrashidi, Fatemeh Keikhah, Fedyeh Haghollahi, Elham Aziminekoo
OBJECTIVE: To compare the pregnancy outcomes achieved by in vitro fertilization (IVF) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (PORs). MATERIALS AND METHODS: In this randomized controlled trial, 77 PORs undergoing IVF were selected and divided into two groups. First group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphene citrate on day 2of the cycle for 5 day that was followed by150IU/day human menopausal gonadotropin (hMG) on day 5 of the cycle...
March 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/27382239/successful-birth-of-south-india-s-first-twins-after-preimplantation-genetic-screening-of-embryos
#7
Priya Selvaraj, Kamala Selvaraj, Kalaichelvi Srinivasan, Mahalakshmi Sivakumar
We report the first documented successful birth of twins following preimplantation genetic screening (PGS) of cleavage stage embryos by array comparative genomic hybridization (CGH) technology, in South India. The case was a 28-year-old woman with the previous history of preclinical pregnancy and a miscarriage in two attempted in vitro fertilization cycles. Day 3 cleavage stage embryos were generated by conventional long protocol with the use of a gonadotropin-releasing hormone analog and a combination of recombinant folliculotropins and human menopausal gonadotropins...
April 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27343309/antagonist-protocol-versus-clomiphene-in-unexplained-infertility-a-randomized-controlled-study
#8
Adel M Nada, Khaled A ElSetohy, Moh'd M Banat, Ahmed F Shaheen
OBJECTIVE: The primary purpose of this randomized controlled trial study was to compare clinical pregnancy rates and ovulation parameters in female patients of unexplained infertility undergoing intrauterine insemination (IUI) using an antagonist protocol versus a conventional clomiphene citrate protocol. MATERIALS AND METHODS: This was a multicenter parallel randomized controlled, open-label trial. A central randomization center used computer generated tables to allocate treatments...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27203307/a-successful-healthy-live-birth-from-a-female-patient-with-hypogonadotropic-hypogonadism-and-oocytes-with-unusually-large-cytoplasmic-inclusions
#9
Candan İltemir Duvan, Aslıhan Pekel, Ummu Gulsum Ercan, Yuksel Onaran Arıkan
This study aimed to report the case of a successful live birth from a woman having oocytes with abnormally large cytoplasmic inclusions. The patient described in this case is a 28 year-old woman with hypogonadotropic hypogonadism (HH) with a history of two previous unsuccessful in vitro fertilization (IVF) attempts offered an antagonist protocol. Stimulation was performed with human menopausal gonadotropin 300 IU/day. The intracytoplasmic sperm injection (ICSI) procedure was performed 4-6 hours after oocyte aspiration for all mature oocytes...
2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27125407/dose-finding-study-of-leuplin-depot-for-prevention-of-premature-luteinizing-hormone-surge-during-controlled-ovarian-stimulation-a-pilot-study-in-intrauterine-insemination-treatment
#10
Heng-Ju Chen, Yu-Hung Lin, Mei-Zen Huang, Kok-Min Seow, Lee-Wen Huang, Bih-Chwen Hsieh, Chii-Ruey Tzeng, Jiann-Loung Hwang
OBJECTIVE: The standard dose of depot gonadotropin releasing hormone agonist (GnRHa) may be too much to prevent premature luteinizing hormone (LH) surge in controlled ovarian stimulation (COS). The purpose of this study was to find out the minimal effective dose of Leuplin depot to prevent premature LH surge in patients undergoing intrauterine insemination (IUI). MATERIALS AND METHODS: From January 2006 to December 2007, unexplained infertile patients who were going to undergo IUI were recruited into the study...
April 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26986651/a-comparison-between-r-lh-and-urinary-supplements-containing-lh-activity-in-patients-undergoing-the-microdose-gnrh-agonist-flare-protocol-for-in-vitro-fertilization-a-pilot-study
#11
Tal Shavit, Mohammed Agdi, Weon Y Son, Josseph Hasson, Michael H Dahan
BACKGROUND: The aim of this study was to compare pregnancy rates and stimulation parameters in patients with diminished ovarian reserve, who were treated with recombinant human luteinizing hormone (r-LH) or menopausal gonadotropins (hMG), as part of a microdose flare protocol. METHODS: A retrospective cohort study was performed. Comparisons between the group that was stimulated with r-LH plus follicle stimulating hormone (FSH) to those treated with hMG and FSH, were performed...
August 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/26963897/does-dehydroepiandrosterone-improve-pregnancy-rate-in-women-undergoing-ivf-icsi-with-expected-poor-ovarian-response-according-to-the-bologna-criteria-a-randomized-controlled-trial
#12
Mohamed M M Kotb, AbdelGany M A Hassan, Ahmed M A AwadAllah
OBJECTIVE: To provide the best available evidence on the role of dehydroepiandrosterone (DHEA) treatment in improving the outcome of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) in women with poor ovarian response (POR). STUDY DESIGN: A randomized controlled trial conducted in Cairo University hospitals and Dar Al-Teb subfertility and assisted conception centre, Giza, Egypt. 140 women undergoing IVF/ICSI with POR according to the Bologna criteria were randomly divided into 2 equal groups...
May 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26945402/controlled-ovarian-stimulation-using-medroxyprogesterone-acetate-and-hmg-in-patients-with-polycystic-ovary-syndrome-treated-for-ivf-a-double-blind-randomized-crossover-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Yun Wang, Qiuju Chen, NingLing Wang, Hong Chen, Qifeng Lyu, Yanping Kuang
Ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation is a current challenge for patients with polycystic ovarian syndrome (PCOS). Our previous studies indicated that progestin can prevent premature luteinizing hormone (LH) surge or moderate/severe OHSS in the general subfertile population, both in the follicular-phase and luteal-phase ovarian stimulation but it is unclear if this is true for patients with PCOS. The aim of the article was to analyze cycle characteristics and endocrinological profiles using human menopausal gonadotropin (hMG) in combination with medroxyprogesterone acetate (MPA) for PCOS patients who are undergoing IVF/intracytoplasmic sperm injection (ICSI) treatments and investigate the subsequently pregnancy outcomes of frozen embryo transfer (FET)...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26945370/efficacy-and-outcome-predictors-of-gonadotropin-treatment-for-male-congenital-hypogonadotropic-hypogonadism-a-retrospective-study-of-223-patients
#14
Zhaoxiang Liu, Jangfeng Mao, Xueyan Wu, Hongli Xu, Xi Wang, Bingkun Huang, Junjie Zheng, Min Nie, Hongbing Zhang
Gonadotropin induces masculinization and spermatogenesis in men with congenital hypogonadotropic hypogonadism (CHH). However, large cohort studies for the efficacy and reliable predictors of this therapy need to be conducted. The aim of this study was to investigate the efficacy of gonadotropin treatment in a large cohort of male CHH patients and analyze putative predictors for successful spermatogenesis. This retrospective study included 223 CHH azoospermic patients without puberty development treated between 2005 and 2014...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26939574/comparison-between-stimulation-with-highly-purified-hmg-or-recombinant-fsh-in-patients-undergoing-ivf-with-gnrh-antagonist-protocol
#15
Tal Shavit, Einat Shalom-Paz, Nivin Samara, Nardin Aslih, Madiea Michaeli, Adrian Ellenbogen
PURPOSE: Highly purified Human Menopausal Gonadotropins (hp-hMG) and recombinant FSH (rFSH) are widely used in assisted reproductive technology (ART). The aim of this study was to compare ART results of the two preparations in GnRH antagonist cycles. METHODS: In this retrospective cohort study, IVF antagonist cycles performed from 2011 through 2013 were reviewed. There were 508 antagonist cycles: 320 stimulated with rFSH and 188 with hp-hMG. For every hp-hMG, two rFSH were matched for patient's age and infertility diagnosis...
March 3, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26924636/strategies-for-improving-outcome-of-assisted-reproduction-in-women-with-polycystic-ovary-syndrome-systematic-review-and-meta-analysis
#16
REVIEW
M Kollmann, W P Martins, M L S Lima, L Craciunas, C O Nastri, A Richardson, N Raine-Fenning
OBJECTIVES: To identify, appraise and summarize the current evidence regarding the efficacy of strategies aimed at improving assisted reproductive techniques in women with polycystic ovary syndrome (PCOS). METHODS: A comprehensive literature search of the standard medical databases was performed. The last electronic search was run in July 2015. The primary outcome measures were live birth/ongoing pregnancy and ovarian hyperstimulation syndrome (OHSS). The secondary outcome measures were clinical pregnancy and miscarriage...
December 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26894126/open-label-prospective-investigator-initiated-study-to-assess-the-clinical-role-of-oral-natural-or-synthetic-progesterone-during-stimulated-iui-cycles-for-unexplained-infertility
#17
Jaideep Malhotra, Korukonda Krishnaprasad
BACKGROUND: Unexplained infertility remains as one of the important subtype of infertility that follows expectant management with Intrauterine Insemination (IUI) in most cases. AIM: To evaluate the clinical role of progesterone supplement as luteal phase support for women with unexplained infertility following stimulation protocol with Clomiphene Citrate (CC)/Human Menopausal Gonadotropin (HMG). MATERIALS AND METHODS: An investigator initiated study to survey the success rate for first cycle of IUI following stimulation protocol with CC/HMG & luteal phase support with oral natural or synthetic progesterone was conducted...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26873125/anti-m%C3%A3-llerian-hormone-concentrations-and-antral-follicle-counts-for-the-prediction-of-pregnancy-outcomes-after-intrauterine-insemination
#18
Francesca Moro, Anna Tropea, Elisa Scarinci, Emanuele Leoncini, Stefania Boccia, Alex Federico, Ornella Alesiani, Antonio Lanzone, Rosanna Apa
OBJECTIVE: To evaluate anti-Müllerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. METHODS: A retrospective study included women with unexplained infertility aged 41years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin...
April 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26843390/comparing-blastocyst-quality-and-live-birth-rates-of-intravaginal-culture-using-invocell%C3%A2-to-traditional-in-vitro-incubation-in-a-randomized-open-label-prospective-controlled-trial
#19
Kevin J Doody, E Jason Broome, Kathleen M Doody
PURPOSE: The purpose of this study is to to compare the efficacy of intravaginal culture (IVC) of embryos in INVOcell™ (INVO Bioscience, MA, USA) to traditional in vitro fertilization (IVF) incubators in a laboratory setting using a mild pre-determined stimulation regimen based solely on anti-mullerian hormone (AMH) and body weight with minimal ultrasound monitoring. The primary endpoint examined was total quality blastocysts expressed as a percentage of total oocytes placed in incubation...
April 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/26814088/-feasibility-of-treatment-of-cesarean-scar-pregnancy-with-dilatation-and-curettage-under-ultrasound-guidance
#20
Zhiyi Liang, Jiying Su, Hua Yang
OBJECTIVE: The present study sought to investigate the predictors of successful dilatation and curettage (D&C) in treatment of cesarean scar pregnancy (CSP). METHODS: Retrospective analysis was conducted in 84 CSP patients undergoing D&C from January 2013 to December 2014. Failure was defined as D&C followed by transcatheter uterine arterial embolization due to uncontrolled hemorrhage. Sub-stratification of success group as residue group or non-residue group was performed according to the residues at the site of cesarean scar after D&C...
October 6, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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