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https://www.readbyqxmd.com/read/28210638/an-unusual-suspect-causing-hypoxemic-respiratory-failure
#1
Masooma Aqeel, Bjorn Batdorf, Horatiu Olteanu, Jayshil J Patel
Introduction: Antisynthetase syndrome (ASS) is characterized by the presence of anti-Jo-1 antibodies in conjunction with clinical findings of fever, polymyositis-dermatomyositis, and interstitial lung disease (ILD). Inflammatory myopathies carry a high risk of malignancy, but this association is less well outlined in ASS. We present the case of a patient with ASS who developed non-Hodgkin's lymphoma with acute hypoxemic respiratory failure. Case Presentation: A 44-year-old female with ASS presented with acute hypoxemic respiratory failure...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28210223/consumer-willingness-to-pay-for-dengue-vaccine-cyd-tdv-dengvaxia-%C3%A2-in-brazil-implications-for-future-pricing-considerations
#2
Isabella P Godói, André S Santos, Edna A Reis, Livia L P Lemos, Cristina M R Brandão, Juliana Alvares, Francisco A Acurcio, Brian Godman, Augusto A Guerra Júnior
Introduction and Objective: Dengue virus is a serious global health problem with an estimated 3.97 billion people at risk for infection worldwide. In December 2015, the first vaccine (CYD-TDV) for dengue prevention was approved in Brazil, developed by Sanofi Pasteur. However, given that the vaccine will potentially be paid via the public health system, information is need regarding consumers' willingness to pay for the dengue vaccine in the country as well as discussions related to the possible inclusion of this vaccine into the public health system...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28203458/weldability-machinability-and-surfacing-of-commercial-duplex-stainless-steel-aisi2205-for-marine-applications-a-recent-review
#3
REVIEW
A Vinoth Jebaraj, L Ajaykumar, C R Deepak, K V V Aditya
In the present review, attempts have been made to analyze the metallurgical, mechanical, and corrosion properties of commercial marine alloy duplex stainless steel AISI 2205 with special reference to its weldability, machinability, and surfacing. In the first part, effects of various fusion and solid-state welding processes on joining DSS 2205 with similar and dissimilar metals are addressed. Microstructural changes during the weld cooling cycle such as austenite reformation, partitioning of alloying elements, HAZ transformations, and the intermetallic precipitations are analyzed and compared with the different welding techniques...
May 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28199075/first-brazilian-consensus-of-advanced-prostate-cancer-recommendations-for-clinical-practice
#4
Andre Deeke Sasse, Evanius Garcia Wiermann, Daniel Herchenhorn, Diogo Assed Bastos, Fabio A Schutz, Fernando Cotait Maluf, George Coura, Igor Alexandre Protzner Morbeck, Juliano J Cerci, Oren Smaletz, Volney Soares Lima, Ari Adamy, Franz Santos de Campos, Gustavo Franco Carvalhal, Leandro Casemiro Cezar, Marcos Francisco Dall'Oglio, Marcus Vinicius Sadi, Rodolfo Borges Dos Reis, Lucas Nogueira
INTRODUCTION: Prostate cancer still represents a major cause of morbidity, and still about 20% of men with the disease are diagnosed or will progress to the advanced stage without the possibility of curative treatment. Despite the recent advances in scientific and technological knowledge and the availability of new therapies, there is still considerable heterogeneity in the therapeutic approaches for metastatic prostate cancer. OBJECTIVES: This article presents a summary of the I Brazilian Consensus on Advanced Prostate Cancer, conducted by the Brazilian Society of Urology and Brazilian Society of Clinical Oncology...
February 16, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28192846/-how-do-primary-care-physicians-manage-their-patients-with-helicobacter-pylori-infection-results-of-a-survey-and-their-implementation-into-the-german-s2k-guideline-2016
#5
Wolfgang Fischbach, Annemarie Zerl, Christine Klassert
Background The German S3 guideline "H. pylori and gastroduodenal ulcer disease" clearly recommends how to diagnose H. pylori infection. It also states when and how eradication therapy should be done. However, there are only few data available on the management of these patients in daily routine. With this survey, we wanted to gather information on how primary care physicians are involved in the management of H. pylori infection and how they follow the guideline recommendations. From this, consequences for the update of the new S2k guideline 2016 and their communication should be derived...
February 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28188855/auditory-processing-assessment-suggests-that-wistar-audiogenic-rat-neural-networks-are-prone-to-entrainment
#6
Hyorrana Priscila Pereira Pinto, Vinícius Rezende Carvalho, Daniel de Castro Medeiros, Ana Flávia Santos Almeida, Eduardo Mazoni Andrade Marçal Mendes, Marcio Flávio Dutra Moraes
Epilepsy is a neurological disease related to the occurrence of pathological oscillatory activity, but the basic physiological mechanisms of seizure remain to be understood. Our working hypothesis is that specific sensory processing circuits may present abnormally enhanced predisposition for coordinated firing in the dysfunctional brain. Such facilitated entrainment could share a similar mechanistic process as those expediting the propagation of epileptiform activity throughout the brain. To test this hypothesis, we employed the Wistar audiogenic rat (WAR) reflex animal model, which is characterized by having seizures triggered reliably by sound...
February 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28188602/umbilical-venous-catheters-placement-evaluation-on-frontal-radiogram-application-of-a-simplified-flow-chart-for-radiology-residents
#7
Sergio Salerno, Chiara Tudisca, Elena Murmura, Domenica Matranga, Giuseppe La Tona, Giuseppe Lo Re, Antonio Lo Casto
BACKGROUND: Umbilical Venous Catheter (UVC) are commonly used in neonatal period; they can be not correctly positioned and could be associated with complications. The purpose of this article is to suggest a flow-chart to evaluate the placement of UVC, testing it in young radiologists-in-training. METHOD: We developed a simple flow-chart to asses, steps by step, UVC placement considering its course and tip location (ideally placed in the atriocaval junction). We tested the flow-chart impact asking to 20 residents to evaluate the placement of 10 UVC before and after they familiarized with the flow-chart and the anatomical findings of a newborn...
February 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28188388/longer-duration-of-untreated-psychosis-hinders-improvement-in-treatment-of-chronic-schizophrenia-community-based-early-intervention-is-an-evidence-based-option
#8
Abdülkadir Tabo, Erkan Aydın, Hüseyin Yumrukçal, Sadık Yiğit, Uğraş Erman Uzun, Oğuz Karamustafalıoğlu
To determine the effects of community-based mental health services on the quality of life and disease symptoms of chronic schizophrenia patients and to determine the effects of duration of untreated psychosis on outcome. The first year records of schizophrenia patients who had been followed up at Zeytinburnu CMHC for at least 12 months, have been used to asses outcome using initial and 12th month quality of life (QoL), positive and negative symptom scale (PANSS) scores. Highly significant improvements were shown in the QoL and PANSS scores...
February 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28177100/-best-practices-on-peritoneal-dialysis-the-audit-of-lazio-region
#9
Massimo Morosetti, Ferruccio Ansali, Moreno Malaguti, Raffaele Lanzetta, Salvatore Di Giulio, Alessandro Domenici, Paolo Menè, Anna Rachele Rocca, Franca Cerroni, Walter Valentini, Armando Filippini, Dario Musone, Marisa Rosa, Valeria Tomei, Francesco De Gennaro, Maurizio Brambilla, Paolo Cogliati
The diffusion of peritoneal methodology can not be something out of the real organizational context and the regional directive can not be the only means to encourage the diffusion. There is the need to provide effective and sustainable levels of assistance through a clinical scientific support and sharing of best-practises. On one side, the aim is to provide an aid by the centers with great expertise in the methodology, recognized as reference points; on the other side, to establish the shared K.P.I.s (Key Performance Index), to asses the clinical effectiveness and measure the objectives to be achieved, through a modality of valuation to establish the real applicability...
January 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28176306/cognitive-differences-between-men-and-women-who-fracture-their-hip-and-impact-on-six-month-survival
#10
Ann L Gruber-Baldini, Mina Hosseini, Denise Orwig, Lynn Grattan, Nancy Chiles Shaffer, Marc Hochberg, Jay Magaziner
OBJECTIVES: There is limited research in cognition and its relationship to mortality after hip fracture among men compared to women. Therefore, the goals of this study were to: (1) compare men and women who fractured their hip on cognition after hospital discharge, and (2) examine the impact of cognition on the differential risk of 6-month mortality between men and women post fracture. DESIGN: Prospective cohort study. SETTING: Eight hospitals in Baltimore, Maryland...
February 8, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28174527/spatial-navigation-and-the-central-complex-sensory-acquisition-orientation-and-motor-control
#11
REVIEW
Adrienn G Varga, Nicholas D Kathman, Joshua P Martin, Peiyuan Guo, Roy E Ritzmann
Cockroaches are scavengers that forage through dark, maze-like environments. Like other foraging animals, for instance rats, they must continually asses their situation to keep track of targets and negotiate barriers. While navigating a complex environment, all animals need to integrate sensory information in order to produce appropriate motor commands. The integrated sensory cues can be used to provide the animal with an environmental and contextual reference frame for the behavior. To successfully reach a goal location, navigational cues continuously derived from sensory inputs have to be utilized in the spatial guidance of motor commands...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28162034/persons-living-with-hiv-infection-on-antiretroviral-therapy-also-consulting-traditional-healers-a-study-in-three-african-countries
#12
Jane N Wanyama, Sharon Tsui, Cynthia Kwok, Rhoda K Wanyenze, Julie A Denison, Olivier Koole, Eric van Praag, Barbara Castelnuovo, Fred Wabwire-Mangen, Gideon P Kwesigabo, Robert Colebunders
Traditional healers provide healthcare to a substantial proportion of people living with HIV infection (PLHIV) in high HIV burden countries in sub-Saharan Africa. However, the impact on the health of retained patients visiting traditional healers is unknown. In 2011, a study to asses adherence to anti-retroviral therapy (ART) performed in 18 purposefully selected HIV treatment centers in Tanzania, Zambia and Uganda showed that 'consulting a traditional healer/herbalist because of HIV' was an independent risk factor for incomplete ART adherence...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28156155/assessment-of-diastolic-dysfunction-arterial-stiffness-and-carotid-intima-media-thickness-in-patients-with-acromegaly
#13
Güven Barış Cansu, Nusret Yılmaz, Atakan Yanıkoğlu, Sebahat Özdem, Aytül Belgi Yıldırım, Gültekin Süleymanlar, Hasan Ali Altunbaş
OBJECTIVE: Early diagnosis and treatment of cardiovascular diseases, the most frequent cause of morbidity and mortality in acromegaly, may be an efficient approach to extending the lifespan of the affected patients. Therefore, it is crucial to determine any cardiovascular diseases in the subclinical period. The study objectives were to determine markers of subclinical atherosclerosis and asses heart structure and functioning. METHODS: This was a cross-sectional single-center study in 53 patients with acromegaly and 22 age- and sex-matched healthy individuals...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28150896/does-apical-negative-pressure-prevent-the-apical-extrusion-of-debris-and-irrigant-compared-with-conventional-irrigation-a-systematic-review-and-meta-analysis
#14
REVIEW
Priscilla Coutinho Romualdo, Katharina Morant Holanda de Oliveira, Mariana Alencar Nemezio, Erika Calvano Küchler, Raquel Assed Bezerra Silva, Paulo Nelson-Filho, Lea Assed Bezerra Silva
The aim of this study was to evaluate if apical negative pressure (ANP) irrigation prevents the apical extrusion of debris and irrigant compared with conventional needle irrigation through a systematic review and meta-analysis. A computer search of dental literature was performed using four different databases. A combination of the terms 'apical negative pressure', 'endovac', 'apical extrusion', 'extrusion' and 'endodontics' was used. Studies that used extracted human teeth with a mature apex and that evaluated the apical extrusion of debris and/or irrigating solution were included...
February 2, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/28149015/role-of-bioflavonoid-quercetin-on-expression-of-urea-cycle-enzymes-astrocytic-and-inflammatory-markers-in-hyperammonemic-rats
#15
Sivamani Kanimozhi, Perumal Subramanian, Sakkaravarthy Shanmugapriya, Subramanian Sathishkumar
This study evaluates the role of quercetin on the expression of urea cycle enzymes, astrocytic, neuronal and inflammatory markers in hyperammonemic rats. Hyperammonemia (provoked by intraperitonial injections of (ammonium chloride-100 mg/kg b.w for 56 days), showed diminished expression of urea cycle enzymes [carbamyl phosphate synthetase-1 (CPS-1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS) and arginase (ARG)] in liver and decreased expression of neuronal and astrocytic markers-glutamine synthase (GS) and phosphate activated glutaminase (PAG) in brain and increased expression of brain inflammatory markers such as interleukin 6 (IL6), inducible nitric oxide synthase (iNOS) and nuclear transcription factor kappa B (NF-κB) (by western blot analysis) and exhibited downregulated expression of soluble guanylate cyclase (sGC), glial fibrillary acidic protein (GFAP) in brain and ASS in liver investigated (by RT-PCR)...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28131962/spectral-structural-characteristics-of-the-extremely-scarce-silver-arsenic-sulfosalts-proustite-smithite-trechmannite-and-xanthoconite-%C3%AE-raman-spectroscopy-evidence
#16
S Kharbish
The spectral - structural features of the rare silver arsenic (Ag-As) sulfosalts, proustite, Ag3AsS3, and the extremely scarce smithite, AgAsS2, trechmannite, AgAsS2 and xanthoconite, Ag3AsS3, were studied by the μ-Raman technique. Stretching - bending vibrations of the pyramidal isolated and interconnected AsS3 groups were responsible for the Raman spectra of the studied sulfosalts. The symmetric and asymmetric stretching modes appear between 380 and 350cm(-1), whereas those of bending (SAsS) vibrations between 335 and 280cm(-1)...
January 21, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28131910/polymorphisms-in-genes-involved-in-enamel-development-are-associated-with-dental-fluorosis
#17
Erika Calvano Küchler, Patricia Nivoloni Tannure, Daniela Silva Barroso de Oliveira, Senda Charone, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva, Marcelo de Castro Costa, Leonardo Santos Antunes, Mônica Diuana Calasans Maia, Lívia Azeredo Alves Antunes
OBJECTIVE: To evaluate the association between polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 genes with dental fluorosis (DF) phenotype. DESIGN: Four hundred and eighty one subjects (108 with DF and 373 DF free) from 6 to 18 years of age were recruited. This population lived in Rio de Janeiro, a city with fluoridation of public water supplies. DF was assessed using the Deańs index modified. Only erupted permanent teeth were assessed. Genetic polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 were analyzed by real-time PCR from genomic DNA...
January 18, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28128979/studies-of-staphylococcus-aureus-fabi-inhibitors-fragment-based-approach-based-on-holographic-structure-activity-relationship-analyses
#18
Thales Kronenberger, Leonardo Rander Asse, Carsten Wrenger, Gustavo Henrique Goulart Trossini, Kathia Maria Honorio, Vinicius Gonçalves Maltarollo
AIM: FabI is a key enzyme in the fatty acid metabolism of Gram-positive bacteria such as Staphylococcus aureus and is an established drug target for known antibiotics such as triclosan. However, due to increasing antibacterial resistance, there is an urgent demand for new drug discovery. Recently, aminopyridine derivatives have been proposed as promising competitive inhibitors of FabI. METHODS: In the present study, holographic structure-activity relationship (HQSAR) analyses were employed for determining structural contributions of a series containing 105 FabI inhibitors...
January 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28128024/studies-of-staphylococcus-aureus-fabi-inhibitors-fragment-based-approach-based-on-holographic-structure-activity-relationship-analyses
#19
Thales Kronenberger, Leonardo Rander Asse, Carsten Wrenger, Gustavo Henrique Goulart Trossini, Kathia Maria Honorio, Vinicius Gonçalves Maltarollo
AIM: FabI is a key enzyme in the fatty acid metabolism of Gram-positive bacteria such as Staphylococcus aureus and is an established drug target for known antibiotics such as triclosan. However, due to increasing antibacterial resistance, there is an urgent demand for new drug discovery. Recently, aminopyridine derivatives have been proposed as promising competitive inhibitors of FabI. METHODS: In the present study, holographic structure-activity relationship (HQSAR) analyses were employed for determining structural contributions of a series containing 105 FabI inhibitors...
January 27, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28122635/comparative-analyses-of-muscle-mri-and-muscular-function-in-anti-synthetase-syndrome-patients-and-matched-controls-a-cross-sectional-study
#20
Helena Andersson, Eva Kirkhus, Torhild Garen, Ragnhild Walle-Hansen, Else Merckoll, Øyvind Molberg
BACKGROUND: Magnetic resonance imaging (MRI) of thigh muscles is increasingly used to assess disease activity and damage extent in chronic myositis, but the validity of the findings is not clear. Here, the primary aim was to compare thigh MRI findings in patients having chronic myositis associated with anti-synthetase syndrome (ASS) and in matched healthy controls. METHODS: Cross-sectional analyses of thigh muscle MRI, muscular function and creatinine kinase (CK) were performed in 68 ASS patients (median disease duration 71 months) and 67 controls matched for age and gender...
January 25, 2017: Arthritis Research & Therapy
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