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https://www.readbyqxmd.com/read/28922194/benign-neonatal-sleep-myoclonus-evokes-somatosensory-responses
#1
Emma Losito, Monika Eisermann, Patricia Vignolo, Shushanik Hovhannisyan, Jean François Magny, Anna Kaminska
PURPOSE: Benign neonatal sleep myoclonus is a common nonepileptic condition occurring in neurologically normal full-term newborns. During jerks, EEG has always been described as normal. The aim of this study was to describe EEG changes associated with the myoclonic jerks. METHODS: Polygraphic video-EEG recordings of four full-term neonates presenting benign neonatal sleep myoclonus were studied. Myoclonic jerks were analyzed regarding their topography, frequency, propagation pattern, and reflex component...
September 14, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28920785/detomidine-and-butorphanol-for-standing-sedation-in-a-range-of-zoo-kept-ungulate-species
#2
Tim Bouts, Joanne Dodds, Karla Berry, Abdi Arif, Polly Taylor, Andrew Routh, Frank Gasthuys
General anesthesia poses risks for larger zoo species, like cardiorespiratory depression, myopathy, and hyperthermia. In ruminants, ruminal bloat and regurgitation of rumen contents with potential aspiration pneumonia are added risks. Thus, the use of sedation to perform minor procedures is justified in zoo animals. A combination of detomidine and butorphanol has been routinely used in domestic animals. This drug combination, administered by remote intramuscular injection, can also be applied for standing sedation in a range of zoo animals, allowing a number of minor procedures...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28901631/equine-behavioral-enrichment-toys-as-tools-for-non-invasive-recovery-of-viral-and-host-dna
#3
Peter A Seeber, Sanatana E Soilemetzidou, Marion L East, Chris Walzer, Alex D Greenwood
Direct collection of samples from wildlife can be difficult and sometimes impossible. Non-invasive remote sampling for the purpose of DNA extraction is a potential tool for monitoring the presence of wildlife at the individual level, and for identifying the pathogens shed by wildlife. Equine herpesviruses (EHV) are common pathogens of equids that can be fatal if transmitted to other mammals. Transmission usually occurs by nasal aerosol discharge from virus-shedding individuals. The aim of this study was to validate a simple, non-invasive method to track EHV shedding in zebras and to establish an efficient protocol for genotyping individual zebras from environmental DNA (eDNA)...
September 12, 2017: Zoo Biology
https://www.readbyqxmd.com/read/28900115/a-phase-ii-study-of-arginine-deiminase-adi-peg20-in-relapsed-refractory-or-poor-risk-acute-myeloid-leukemia-patients
#4
Hui-Jen Tsai, Shih Sheng Jiang, Wen-Chun Hung, Gautam Borthakur, Sheng-Fung Lin, Naveen Pemmaraju, Elias Jabbour, John S Bomalaski, Ya-Ping Chen, Hui-Hua Hsiao, Ming-Chung Wang, Ching-Yuan Kuo, Hung Chang, Su-Peng Yeh, Jorge Cortes, Li-Tzong Chen, Tsai-Yun Chen
Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits growth in various ASS-deficient cancers by depleting arginine. The efficacy of pegylated ADI (ADI-PEG20) in relapsed/refractory/poor-risk acute myeloid leukemia (AML) was evaluated in 43 patients in a prospective, phase II trial (NCT01910012 (10/07/2013), https://clinicaltrials.gov/ct2/show/NCT01910012?term = ADI-PEG20&rank = 12 ). Despite almost all pre-treatment tumor samples showing ASS deficiency, the best response among 21 evaluable patients was complete response (CR) in 2 (9...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887786/assessing-psycho-social-barriers-to-rehabilitation-in-injured-workers-with-chronic-musculoskeletal-pain-development-and-item-properties-of-the-yellow-flag-questionnaire-yfq
#5
Cornelia Rolli Salathé, Maurizio Alen Trippolini, Livio Claudio Terribilini, Michael Oliveri, Achim Elfering
Purpose To develop a multidimensional scale to asses psychosocial beliefs-the Yellow Flag Questionnaire (YFQ)-aimed at guiding interventions for workers with chronic musculoskeletal (MSK) pain. Methods Phase 1 consisted of item selection based on literature search, item development and expert consensus rounds. In phase 2, items were reduced with calculating a quality-score per item, using structure equation modeling and confirmatory factor analysis on data from 666 workers. In phase 3, Cronbach's α, and Pearson correlations coefficients were computed to compare YFQ with disability, anxiety, depression and self-efficacy and the YFQ score based on data from 253 injured workers...
September 8, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28884012/performance-of-seven-criteria-to-assess-ca125-increments-among-ovarian-cancer-patients-monitored-during-first-line-chemotherapy-and-the-post-therapy-follow-up-period
#6
Suher O Abu Hassan, Dorte L Nielsen, Malgorzata K Tuxen, Per H Petersen, György Sölétormos
AIM: To investigate seven CA125 criteria to monitor progressive ovarian cancer among patients with stage IC-IV disease. MATERIALS & METHODS: Four criteria were used to asses CA125 increments starting from concentrations ≥35 U/ml and three criteria to asses increments starting from concentrations <35 U/ml. RESULTS: A total of 231 patients were allocated to CA125 monitoring. The performances of the CA125 criteria were similar with sensitivities of 30-55%, negative predictive values of 28-46%, positive predictive values of 90-100% and median lead times of 26-87 days...
August 2017: Future Science OA
https://www.readbyqxmd.com/read/28882160/intrinsic-fluorescence-of-the-clinically-approved-multikinase-inhibitor-nintedanib-reveals-lysosomal-sequestration-as-resistance-mechanism-in-fgfr-driven-lung-cancer
#7
Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R Kowol, Petra Heffeter, Michael Grusch, Walter Berger
BACKGROUND: Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedical research. It constitutes a prerequisite for a better understanding of the molecular mechanisms underlying drug action and resistance development. Hyperactivated fibroblast growth factor receptors (FGFRs) constitute a promising therapy target in several types of malignancies including lung cancer. The clinically approved small-molecule FGFR inhibitor nintedanib exerts strong cytotoxicity in FGFR-driven lung cancer cells...
September 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28877283/bacterial-endotoxin-adhesion-to-different-types-of-orthodontic-adhesives
#8
Priscilla Coutinho Romualdo, Thaís Rodrigues Guerra, Fábio Lourenço Romano, Raquel Assed Bezerra da Silva, Izaíra Tincani Brandão, Célio Lopes Silva, Lea Assed Bezerra da Silva, Paulo Nelson-Filho
Objective: The aim of this study was to assess whether LPS adheres to orthodontic adhesive systems, comparing two commercial brands. Material and Methods: Forty specimens were fabricated from Transbond XT and Light Bond composite and bonding agent components (n=10/component), then contaminated by immersion in a bacterial endotoxin solution. Contaminated and non-contaminated acrylic resin samples were used as positive and negative control groups, respectively. LPS quantification was performed by the Limulus Amebocyte Lysate QCL-1000™ test...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28871713/cognitive-functions-and-serum-cortisol-concentration-in-perimenopausal-and-postmenopausal-women-working-non-manually
#9
Dorota Raczkiewicz, Beata Sarecka-Hujar, Alfred Owoc, Iwona Bojar
OBJECTIVES: To asses a possible relationship between serum cortisol concentration and cognitive function in peri- and postmenopausal women engaging in non-manual work. METHODS: The Montreal Cognitive Assessment (MoCA) was used to screen women for the study and the Computerized Neurocognitive-assessment Software (CNS) Vital Signs to diagnose cognitive functions. RESULTS: Cognitive functions and serum cortisol concentration did not differ between women in early and late perimenopause and postmenopause...
August 5, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28864398/the-role-of-asymptomatics-and-dogs-on-leishmaniasis-propagation
#10
Lourdes Esteva, Cristobal Vargas, Cruz Vargas de León
Leishmaniasis is a parasite disease transmitted by the bites of sandflies. Cutaneous leishmaniasis is the most common form of the disease and it is endemic in the Americas. Around 70 animal species, including humans, have been found as natural reservoir hosts of leishmania parasites. Among the reservoirs, dogs are the most important ones due to their proximity to the human habitat. Infection by leishmaniasis does not invariably cause illness in the host, and it also can remain asymptomatic for a long period, specially in dogs...
August 31, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28863335/an-efficient-analytical-method-for-determination-of-s-phenylmercapturic-acid-in-urine-by-hplc-fluorimetric-detector-to-assessing-benzene-exposure
#11
Michele P Rocha Mendes, Josianne Nicácio Silveira, Leiliane Coelho Andre
Benzene is an important occupational and environmental contaminant, naturally present in petroleum and as by-product in the steel industry. Toxicological studies showed pronounced myelotoxic action, causing leukemic and others blood cells disorders. Assessing of benzene exposure is performed by biomarkers as trans, trans-muconic acid (AttM) and S-phenylmercapturic acid (S-PMA) in urine. Due to specificity of S-PMA, this biomarker has been proposed to asses lower levels of benzene in air. The aim of this study was to validate an analytical method for the quantification of S-PMA by High-Performance Liquid Chromatography with fluorometric detector...
August 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28859863/catechol-o-methyltransferase-gene-val158met-polymorphisms-and-anxious-symptoms-in-early-childhood-the-roles-of-hypothalamus-pituitary-adrenal-axis-reactivity-and-life-stress
#12
Haroon I Sheikh, Katie R Kryski, Yuliya Kotelnikova, Elizabeth P Hayden, Shiva M Singh
Individual differences in hypothalamus-pituitary-adrenal (HPA) axis reactivity to stress (measured via salivary cortisol) have been widely implicated in the etiology of internalizing problems such as depression and anxiety. Literature suggests that stress during early childhood is an important source of contextual risk although its effects may be moderated by polymorphisms of neurotransmitter genes. The COMT val158met is one such polymorphism, and literature documents its link to internalizing problems. To extend these findings, and to better understand the role of this polymorphism in developmental risk, we investigated links between the val158met polymorphism and early-age cortisol response...
August 30, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28859492/retzius-sparing-robotic-assisted-laparoscopic-radical-prostatectomy-a-safe-surgical-technique-with-superior-continence-outcomes
#13
Rashid Sayyid, William G Simpson, Caroline Lu, Martha Terris, Zachary Klaassen, Rabii Madi
PURPOSE: To report early operative outcomes and asses continence in 100 consecutive patients who underwent Retzius-sparing robotic-assisted laparoscopic radical prostatectomy Materials and Methods: This was a prospective, single-center, consecutive case series of 100 and 100 patients undergoing a Retzius-sparing and a conventional robotic-assisted laparoscopic radical prostatectomy, respectively, by a single surgeon between March 2015 and April 2017. RESULTS: Baseline patient characteristics were similar between the two groups...
August 31, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28837225/towards-image-quality-assessment-in-mammography-using-model-observers-detection-of-a-calcification-like-object
#14
Ramona W Bouwman, Alistair Mackenzie, Ruben E van Engen, Mireille J M Broeders, Kenneth C Young, David R Dance, Gerard J den Heeten, Wouter J H Veldkamp
PURPOSE: Model observers (MOs) are of interest in the field of medical imaging to asses image quality. However, before procedures using MOs can be proposed in quality control guidelines for mammography systems, we need to know whether MOs are sensitive to changes in image quality and correlations in background structure. Therefore, as a proof of principle, in this study human and model observer (MO) performance are compared for the detection of calcification like objects using different background structures and image quality levels of unprocessed mammography images...
August 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28830984/arginine-deprivation-therapy-putative-strategy-to-eradicate-glioblastoma-cells-by-radiosensitization
#15
C Noreen Hinrichs, Mirjam Ingargiola, Theresa Käubler, Steffen Löck, Achim Temme, Alvaro Köhn-Luque, Andreas Deutsch, Olena Vovk, Oleh Stasyk, Leoni A Kunz-Schughart
Tumor cells - even if non-auxotrophic - are often highly sensitive to arginine deficiency. We hypothesized that arginine deprivation therapy (ADT) if combined with irradiation could be a new treatment strategy for glioblastoma (GBM) patients since systemic ADT is independent of local penetration and diffusion limitations. A proof-of-principle in vitro study was performed with ADT been mimicked by application of recombinant human arginase or arginine-free diets. <p>ADT inhibited 2-D growth and cell cycle progression, and reduced growth recovery after completion of treatment in four different GBM cell line models...
August 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28827941/analytical-study-of-short-and-long-term-results-of-home-based-palliative-care-services-to-cancer-patients
#16
Dhritiman Datta, Gautam Majumdar, Shiromani Debbarma, Badan Janapati, Amit Kumar Datta
AIMS AND OBJECT: Identification and selection of patients suffering from terminal stage in bed ridden condition upto village level and to determine the type of palliative care need. Also to asses the effectiveness of the palliative care provided at the bed side. MATERIALS: All registered patients under palliative care of Regional Cancer Centre, Agartala from 2014 April to 2016 March. METHODS: A retrospective study. Ten teams comprising of doctors, nurses, pharmacists & Social Workers were trained and engaged in this study for symptom assessment and pain relief of palliative patients...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28817610/an-overview-of-financial-sources-being-utilized-to-support-zika-virus-published-research
#17
Keisha Goodridge, Ludovic Reveiz, Vanessa Elias
BACKGROUND: Since its initial detection in Brazil in 2015, Zika Virus (ZIKV) has spread rapidly throughout most of the Caribbean and South, Central and North America. An upsurge in congenital syndrome associated with ZIKV and Guillain-Barre Syndrome (GBS) has been associated with the increase in ZIKV. This amplification in numbers led to the need for funded research initiatives focusing on various countries globally and on specific experimental types. OBJECTIVES: To determine the financial institutions involved in the production of primary research into the ZIKV epidemic...
2017: PloS One
https://www.readbyqxmd.com/read/28813782/urea-cycle-pathway-targeted-therapeutic-action-of-naringin-against-ammonium-chloride-induced-hyperammonemic-rats
#18
Arumugam Ramakrishnan, Natesan Vijayakumar
Ammonia is a well-known neurotoxin that causes liver disease and urea cycle disorder. Excessive ammonia content in the blood leads to hyperammonemic condition and affects both excitatory and inhibitory neurotransmission including brain edema and coma. Naringin, a plant bioflavonoid present in various citrus fruits and mainly extracted from the grape fruit. This study was designed to assess the protective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitoneal injections (i...
August 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28813096/cytotoxicity-and-bacterial-membrane-destabilization-induced-by-annona-squamosa-l-extracts
#19
Nícolas C C Pinto, Jucélia B Silva, Laura M Menegati, Maria Clara M R Guedes, Lucas B Marques, Thiago P DA Silva, Rossana C N DE Melo, Elaine M DE Souza-Fagundes, Marcos J Salvador, Elita Scio, Rodrigo L Fabri
This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were used. ASL showed significant antibacterial activity against S. aureus, K. pneumoniae and E. faecalis with MIC values of 78, 78 and 39 µg/mL respectively. Moreover, ASL exhibited significant biofilm disruption, rapid time dependent kinetics of bacterial killing, increased membrane permeability and significantly reduced the cell numbers and viability...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28812021/association-analysis-of-arsenic-induced-straighthead-in-rice-oryza-sativa-l-based-on-the-selected-population-with-a-modified-model
#20
Xiaobai Li, Biaolin Hu, Xuhao Pan, Ning Zhang, Dianxing Wu
A rice physiological disorder makes mature panicle keep erect with empty grains termed as "straighthead." Straighthead causes yield losses and is a serious threat to rice production worldwide. Here, a new study of association mapping was conducted to identify QTL involved in straighthead. A subset of 380 accessions was selected from the USDA rice core collection and genotyped with 72 genome-wide SSR markers. An optimal model implemented with principle components (PCs) was used in this association mapping. As a result, five markers were identified to be significantly associated with straighthead...
2017: BioMed Research International
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