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Yimei Zhang, Liqun Wang, Jie Chen, Yalong Zhao, Yuxian Lai, Panpan Wu
The conventional risk assessment methods may be defective for more effective health risk assessment due to ignoring heavy metal species and the accuracy and integrity of sampling and analysis results. Using the accurate and integral data to quantify the human health effects of metal species can provide great support for more effective health risk assessment. This study presents a new methodology to optimize sampling and analysis results for implementing the spatial human health risk of heavy metal species in contaminated sites...
May 17, 2018: Science of the Total Environment
Yanjiao Ma, Ling Xue, Xin Chen, Yingbo Kang, Yong Wang, Liqing Wang
Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacokinetic (PPK) approaches could achieve it and many PPK studies of theophylline have been reported in infants. However, none was conducted in Chinese adults and none has explored the effect of CYP1A2 genotypes on the PPK characteristics of theophylline in adults. Objective To evaluate the PPK characteristics of theophylline and to assess the possible influence of covariates, including CYP1A2 genotypes, on theophylline clearance in Chinese adult patients...
May 18, 2018: International Journal of Clinical Pharmacy
Carmela De Santo, Paul Cheng, Andrew Beggs, Sharon Egan, Alberto Bessudo, Francis Mussai
BACKGROUND: Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell responses, yet a number of patients will relapse and die of disease. Here, we report the first sustained complete remission in a patient with metastatic melanoma who failed two immunotherapy strategies, by targeting tumour arginine metabolism...
May 18, 2018: Journal of Hematology & Oncology
John B Bartholomew, Esbelle M Jowers, Gregory Roberts, Anna-Mária Fall, Vanessa L Errisuriz, Sharon Vaughn
Purpose: Given the need to find more opportunities for physical activity within the elementary school day, this study was designed to asses the impact of I-CAN!, active lessons on: 1) student physical activity (PA) outcomes via accelerometry; and 2) socioeconomic status (SES), race, sex, body mass index (BMI), or fitness as moderators of this impact. Methods: Participants were 2,493 fourth grade students (45.9% male, 45.8% white, 21.7% low SES) from 28 central Texas elementary schools randomly assigned to intervention (n=19) or control (n=9)...
January 2018: Translational Journal of the American College of Sports Medicine
Haskel J Greenfield, Itzhaq Shai, Tina L Greenfield, Elizabeth R Arnold, Annie Brown, Adi Eliyahu, Aren M Maeir
Analysis of a sacrificed and interred domestic donkey from an Early Bronze Age (EB) IIIB (c. 2800-2600 BCE) domestic residential neighborhood at Tell eṣ-Ṣâfi/Gath, Israel, indicate the presence of bit wear on the Lower Premolar 2 (LPM2). This is the earliest evidence for the use of a bit among early domestic equids, and in particular donkeys, in the Near East. The mesial enamel surfaces on both the right and left LPM2 of the particular donkey in question are slightly worn in a fashion that suggests that a dental bit (metal, bone, wood, etc...
2018: PloS One
Arthur S Cunha, Willian Orlando Castillo, Catarina Satie Takahashi, Erika Calvano Küchler, Raquel Assed Bezerra Segato, Léa Assed Bezerra da Silva, Fábio Lourenço Romano, Mírian Aiko Nakane Matsumoto, Paulo Nelson-Filho
OBJECTIVES: To evaluate the genotoxic and cytotoxic effects of Haas appliances through micronuclei test and cytogenetic damage analysis in buccal mucosa epithelial cells of patients undergoing orthodontic treatment. MATERIALS AND METHODS: Twenty-eight patients, 6-12 years of age and of both genders, who required a Haas appliance for the correction of a posterior crossbite were included. Epithelial cells from the mucosa were collected by gently scraping the inside of both the right and left cheeks...
May 15, 2018: Angle Orthodontist
Johannes R Björk, Francis K C Hui, Robert B O'Hara, Jose M Montoya
In addition to the processes structuring free-living communities, host-associated microbiota are directly or indirectly shaped by the host. Therefore, microbiota data have a hierarchical structure where samples are nested under one or several variables representing host-specific factors, often spanning multiple levels of biological organization. Current statistical methods do not accommodate this hierarchical data structure, and therefore cannot explicitly account for the effect of the host in structuring the microbiota...
May 14, 2018: Molecular Ecology
Vesna Martic, Ivo Bozovic, Ivana Berisavac, Ivana Basta, Stojan Peric, Milica Babic, Sonja Lukic Rajic, Bogdan Bjelica, Olivera Stojiljkovic Tamas, Aleksandar Stojanov, Marija Grunauer, Mina Cobeljic, Nenad Komatina, Vanja Djuric, Milutin Petrovic, Balsa Vujovic, Aleksandra Dominovic Kovacevic, Gordana Djordjevic, Dejana Jovanovic, Zorica Stevic
A majority of patients with Guillain-Barré syndrome (GBS) have tendency of a good recovery. Our aim was to evaluate the outcome of the disease 1 and 3 years after GBS symptom onset. METHODS: During 2014, GBS was diagnosed in 82 patients in seven tertiary healthcare centers. Neurological follow-up was conducted in 57 (70%) patients after 1 year, and in 54 (66%) after 3 years. Functional disability was estimated according to the GBS disability scale (GDS), with a score of 0-3 indicating mild disability and a score of 4-6 indicating severe disability during acute phase, whereas a score >1 indicated poor recovery on follow-ups...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
L Cornara, A Smeriglio, J Frigerio, M Labra, E Di Gristina, M Denaro, E Mora, D Trombetta
Today, in many European countries, people are looking for wild edible plants to experience new tastes and flavors, by following the new trend of being green and environmentally friendly. Young borage and spinach leaves can be easily confused by inexpert pickers with those of other plants, including poisonous ones, such as Mandragora autumnalis Bertol. (mandrake) or Digitalis purpurea L. (foxglove), common in southern and northern Italy respectively. In the last twenty years, several cases of intoxication by accidental ingestion of mandrake and foxglove have been reported...
May 10, 2018: Food and Chemical Toxicology
Juan Pena, Nihan Dulger, Tanya Singh, Jing Zhou, Robert Majeska, Stephen Redenti, Maribel Vazquez
Emerging therapies have begun to evaluate the abilities of Müller glial cells (MGCs) to protect and/or regenerate neurons following retina injury. The migration of donor cells is central to many reparative strategies, where cells must achieve appropriate positioning to facilitate localized repair. Although chemical cues have been implicated in the MGC migratory responses of numerous retinopathies, MGC-based therapies have yet to explore the extent to which external biochemical stimuli can direct MGC behavior...
May 10, 2018: Experimental Eye Research
Priscilla Coutinho Romualdo, Nayane Barbosa Fernandes Furlanetto Cunha, Graziela Bianchi Leoni, Manoel Damião Sousa-Neto, Alberto Consolaro, Alexandra Mussolino de Queiroz, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Paulo Nelson-Filho
OBJECTIVE: The aim of this study was to evaluate bone mineral density (BMD) and microarchitecture in femurs and maxillary bones of ovariectomized (OVX) rats treated or not treated with alendronate (ALD) or odanacatib (ODN). STUDY DESIGN: Twenty rats were divided into groups: SHAM, OVX, OVX/ALD, and OVX/ODN. After 12 weeks, the femurs and maxillae were removed and subjected to 3-dimensional analysis by micro-computed tomography. Results were analyzed with 1-way analysis of variance and Tukey's post hoc test (α = 0...
April 13, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Diego Alberto Morales Urrea, Patricia Mónica Haure, Fernando Sebastián García Einschlag, Edgardo Martín Contreras
Enzymatic decolourization of azo-dyes could be a cost-competitive alternative compared to physicochemical or microbiological methods. Stoichiometric and kinetic features of peroxidase-mediated decolourization of azo-dyes by hydrogen peroxide (P) are central for designing purposes. In this work, a modified version of the Dunford mechanism of peroxidases was developed. The proposed model takes into account the inhibition of peroxidases by high concentrations of P, the substrate-dependant catalatic activity of peroxidases (e...
May 9, 2018: Environmental Science and Pollution Research International
Martin Salö, Pernilla Stenström, Magnus Anderberg, Einar Arnbjörnsson
Background  We determined time frames for dilatation of anastomotic strictures (ASs) occurring during the first 2 years after esophageal atresia (EA) repair. Methods  A retrospective study was conducted on children with EA (Gross type C) who underwent direct repair between January 2008 and March 2015 at a single tertiary center of pediatric surgery. Endoscopic signs of stricture were indications for dilatation because the endoscopy provides more reliable information than X-ray imagining methods. Results  Among our cohort of 49 children with EA, 19 (39%) required at least one esophageal dilatation...
April 2018: Surgery Journal
J G Lorén, Maribel Farfán, M C Fusté
The definition of species boundaries constitutes an important challenge in biodiversity studies. In this work we applied the Generalized Mixed Yule Coalescent (GMYC) method, which determines a divergence threshold to delimit species in a phylogenetic tree. Based on the tree branching pattern, the analysis fixes the transition threshold between speciation and the coalescent process associated with the intra-species diversification. This approach has been widely used to delineate eukaryote species and establish their diversification process from sequence data...
2018: Frontiers in Microbiology
Daniela Silva Barroso de Oliveira, Raquel Assed Bezerra Segato, Sara Oliveira, André Luiz Tannus Dutra, Adriana Stone Dos Santos, Ananda Deva Noronha Praxedes, Leandro Coelho Belém, Livia Azeredo Antunes, Andrea Lips, Paulo Nelson-Filho, Léa Assed Bezerra da Silva, Gutemberg Gomes Alves, Leonardo Santos Antunes, Erika Calvano Küchler
OBJECTIVE: This replication study aimed to evaluate an association between caries experience and polymorphisms in DEFB1 and miRNA202 in two different Brazilian groups. DESIGN: The population consisted in 312 Brazilian children. Genomic DNA for was extracted from buccal cells isolated from saliva. The genotyping analysis of the polymorphisms in DEFB1 and miRNA202 was performed by real-time polymerase chain reactions. The associations between caries experience, genotype and allele distribution was performed, with an alpha of 0...
April 20, 2018: Archives of Oral Biology
Roshni Vara, Anil Dhawan, Maesha Deheragoda, Stephanie Grünewald, Germaine Pierre, Nigel D Heaton, Hector Vilca-Melendez, Nedim Hadžić
Citrullinemia or ASS deficiency in its classical form presents in the neonatal period with poor feeding, hyperammonemia, encephalopathy, seizures, and if untreated can be fatal. Despite advances in medical therapy, neurocognitive outcomes remain suboptimal. LT has emerged as a potential management option. A retrospective single-center review identified 7 children with a median age of 1.1 years (range, 0.6-5.8) at referral. Five children presented clinically, and 2 were treated prospectively from birth due to positive family history...
May 3, 2018: Pediatric Transplantation
Angela Notarnicola, Fabrizio Perroni, Alessio Campese, Giuseppe Maccagnano, Antonio Monno, Biagio Moretti, Silvio Tafuri
Introduction: The aims of study were: 1) to verify the effectiveness of different stretching methods and training; 2) to compare the effects with only training on the flexibility of joints in basketball players. Methods: 30 males basketball players (age: 17±1yrs; BMI: 23.4±3.1), divided into 2 groups (15 experimental group - EG - and 15 control group, CG), participated to study. EG performed 5 different stretching method: passive stretching, active stretching, postural protocol, PNF and dynamic stretching...
October 2017: Muscles, Ligaments and Tendons Journal
Paula A O Araujo, Marilda Guimarães Silva, Eduardo Ferreira Borba, Samuel K Shinjo
OBJECTIVES: A high frequency of metabolic syndrome (MetS) has been recently described in different idiopathic inflammatory myopathies, but not in antisynthetase syndrome (ASS). Therefore, the aim of the present study was to determine the prevalence of MetS in ASS and also its possible association with cardiovascular the risk factors and ASS-related disease characteristics. METHODS: A cross-sectional single centre study of 42 consecutive ASS patients was conducted from 2012 to 2015 and compared to 84 healthy individuals matched for gender, age, ethnicity and body mass index-matched (control group)...
March 2018: Clinical and Experimental Rheumatology
Piotr Rutkowski, Paweł Teterycz, Anna Klimczak, Elżbieta Bylina, Katarzyna Szamotulska, Iwona Lugowska
INTRODUCTION: Neutrophil-to-lymphocyte ratio (NLR) was shown to be prognostic in several solid malignancies. There are limited data about predictive/prognostic value of NLR during targeted therapy of patients with advanced gastrointestinal stromal tumors (GIST). The aim of this study was to asses a clinical value of this ratio in patients with advanced GIST. METHODS: Between 2001 and 2016, 385 patients with metastatic/unresectable GIST treated initially with imatinib were included in the analysis...
April 1, 2018: Tumori
Etevaldo Matos Maia Filho, Amanda Martins Calisto, Rudys Rodolfo De Jesus Tavarez, Claudia de Castro Rizzi, Raquel Assed Bezerra Segato, Léa Assed Bezerra da Silva
Introduction: The study aimed to correlate the Periapical Index (PAI), obtained by way of periapical radiographs, with the volume of chronic periapical lesion, obtained through cone-beam computed tomography (CBCT), in the permanent teeth. Methods and Materials: Radiographs and CBCT images were selected from 35 single-rooted permanent teeth, with fully formed apices, with a diagnosis of pulp necrosis and chronic apical periodontitis that was radiographically visible...
2018: Iranian Endodontic Journal
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