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TSH AND Iodine

Julia Elisabeth von Oettingen, Tesha Dawn Brathwaite, Christopher Carpenter, Ric Bonnell, Xuemei He, Lewis E Braverman, Elizabeth N Pearce, Philippe Larco, Nancy Charles Larco, Eddy Jean-Baptiste, Rosalind S Brown
CONTEXT: Iodine deficiency is the leading cause of preventable neurodevelopmental delay in children worldwide. It is a possible public health concern in Haiti. OBJECTIVE: To perform a population iodine survey in Haitian young children, and its influence by environmental factors. DESIGN: Cross-sectional study, March-June 2015. SETTING: Community churches in 3 geographical regions in Haiti. PARTICIPANTS: 299 healthy Haitian children aged 9 months to 6 years; 100 enrolled in coastal (C) and mountainous (M) regions, and 99 in an urban region (U)...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
Sarah C Bath, Victor J M Pop, Victoria L Furmidge-Owen, Maarten Broeren, Margaret P Rayman
Background Though iodine deficiency in pregnancy is a matter of public-health concern, a functional measure of iodine status is lacking. The thyroid-specific protein, thyroglobulin (Tg), which reflects thyroid size, has shown promise as a functional measure in studies of children and adults, but data in pregnancy are sparse. In a cohort of mildly-to-moderately iodine-deficient pregnant women, we aimed to explore whether serum Tg is a sensitive functional biomarker of iodine status and to examine longitudinal change in Tg with gestational age...
October 20, 2016: Thyroid: Official Journal of the American Thyroid Association
Anelia V Bivolarska, Ana I Maneva, Penka D Gatseva, Mariana N Katsarova
AIM: To find correlations between high thiocyanate and nitrate levels and low selenium levels and the indicators of the iodine and iron status of postpartum women. MATERIALS AND METHODS: The study included 41 mothers aged 26.4±5.9 yrs from Asenovgrad and nearby villages. Urinary iodine was determined by the Sandell-Kolthoff reaction and thiocyanate - by the interaction of these ions with acidic solution of KMnO4; for serum nitrates we used the colorimetric method; serum selenium was assessed by electro-thermal atomic-absorption spectrophotometry; thyroxin (FT4), the thyroid stimulating hormone (TSH), serum ferritin (SF), and serum transferrin receptor (sTfR) were determined using ELISA; Hb levels were determined by hematology analyzer...
September 1, 2016: Folia Medica
M H Listewnik, M J Listewnik, T Miazgowski, K Jaskólska, K Jasiakiewicz, B Birkenfeld
Introduction: Earlier studies suggest increased serum levels of thyroid peroxidase antibodies (TPOAb) in some cases with non-autoimmune hyperthyroidism. The aim of the study was to assess the incidence of hypothyroidism in patients with nodular toxic goitre and toxic adenoma at 12 months after radioactive iodine therapy in the relation to TPOAb levels. Patients & Measurements: The study comprised 100 patients (83 females; 17 males) treated with radioactive iodine therapy. Serum concentrations of thyrotropin, free thyroxin, TPOAb, and anti-TSH receptor antibodies were assessed at baseline and 12 months after radioactive iodine therapy...
October 2016: Experimental and Clinical Endocrinology & Diabetes
Pawel Kawalec, Iwona Malinowska-Lipień, Tomasz Brzostek, Maria Kózka
Thyroid carcinoma is the most prevalent endocrine malignancy, with an increasing incidence over the past decades. Treatment of differentiated thyroid cancer consists of surgery followed by radioactive iodine (RAI) ablation of the thyroid remnant, and TSH suppression. Among new therapeutic solutions for patients with advanced RR-DTC stage, the most promising seem to be sorafenib and lenvatinib, up to now considered to be orphan drugs. Areas covered: We performed a systematic review of medical databases to collect all eligible clinical trials referring to the topic of our analysis...
October 13, 2016: Expert Review of Anticancer Therapy
Michala Vosátková, Denisa Janíčková Žďarská, Václav Zamrazil, Martina Salátová, Martin Hill, Karel Vondra
INTRODUCTION: In patients with type 1 and 2 diabetes mellitus only rare data concerning the status of iodine supplementation and impact of possible iodine deficiency is available. AIM: To get basic information about (a) state of supply with iodine in patients with type 1 diabetes mellitus (DM1T), (b) the difference from non-diabetic population, (c) possible association of iodine saturation with some clinical and laboratory features of the diabetic syndrome, including the state of thyroid gland...
2016: Vnitr̆ní Lékar̆ství
Xiaomei Zhang, Baoting Yao, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Xiaochun Teng, Cheng Han, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Liu Yang, Chenling Fan, Weiping Teng, Zhongyan Shan
BACKGROUND: Self-sequential longitudinal reference interval may be expected to minimize the inter-individual variation of thyroid function. Comparison between self-sequential longitudinal reference interval and cross-sectional reference interval in pregnancy has not been well investigated. The objective of this study is to establish a stringent self-sequential longitudinal reference interval (SLRI) of thyroid function in pregnant women and to compare it with the conventional cross-sectional reference interval (CSRI)...
October 12, 2016: Thyroid: Official Journal of the American Thyroid Association
Sara Stinca, Maria Andersson, Sandra Weibel, Isabelle Aeberli-Herter, Ralph Fingerhut, Sueppong Gowachirapant, Sonja Y Hess, Nidhi Jaiswal, Tomislav Jukić, Zvonko Kusic, Ngoako Solomon Mabapa, Ashwini Kumar Nepal, Teofilo O L San Luis, Jia Qing Zhen, Michael Bruce Zimmermann
CONTEXT: Thyroglobulin (Tg) may be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. OBJECTIVES: Our aims were to: 1) establish a reference range for DBS-Tg in iodine-sufficient PW; 2) test this reference range in PW with a range of iodine intakes; and 3) determine if co-measurement of Tg antibodies (Ab) is necessary to define population iodine status. Design, Settings and Participants: Standardized cross-sectional studies in 3870 PW from 11 countries with iodine intakes from deficient to more-than-adequate...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Eric De Zoysa, Manjula Hettiarachchi, Chandrani Liyanage
BACKGROUND: Iodine deficiency and thyroid dysfunction during pregnancy is associated with number of adverse outcomes that includes mental and physical disabilities creating a huge human and economic burden in later life. Several indicators are used to assess the iodine status of a population: thyroid size by palpation and/or by ultrasonography, urinary iodine excretion and the blood thyroid hormone profile. METHODS: This prospective study was designed to assess the iodine nutrition during the course of pregnancy with reference to urine iodine concentration (UIC) and thyroid determinants among 425 pregnant women from Galle district, Sri Lanka...
October 12, 2016: BMC Pregnancy and Childbirth
Na Liu, Zhaowei Meng, Qiang Jia, Jian Tan, Guizhi Zhang, Wei Zheng, Renfei Wang, Xue Li, Tianpeng Hu, Arun Upadhyaya, Pingping Zhou, Sen Wang
(131)I treatment is an important management method for patients with differentiated thyroid cancer (DTC). Unsuccessful (131)I ablation drastically affects the prognosis of the patients. This study aimed to analyze potential predictive factors influencing the achievement of a disease-free status following the first (131)I therapy. This retrospective review included 315 DTC patients, and multiple factors were analyzed. Tumor size, pathological tumor stage, lymph node (LN) metastasis, distant metastasis, American Thyroid Association recommended risks, pre-ablation thyroglobulin (Tg), and thyroid stimulating hormone (TSH) displayed significant differences between unsuccessful and successful group...
October 10, 2016: Scientific Reports
F Acıbucu, D O Acıbucu, Ö B Akkar, H S Dokmetas
Introduction: Radioactive iodine (RAI) ablation treatment is used for patients diagnosed with well-differentiated thyroid cancer in order to reduce the risk of recurrence. RAI ablation treatment can adversely affect gonads in males and females. In this study, we aimed to determine ovary damage and infertility risk due to RAI, using serum anti-Müllerian hormone (AMH) level, in females who received RAI ablation treatment. Materials and Methods: 45 female patients who have not gone through the menopause and had received RAI ablation treatment for well-differentiated thyroid cancer in premenopausal period, and 40 healthy females as control groups were included in this study...
October 6, 2016: Experimental and Clinical Endocrinology & Diabetes
J Capdevila, J C Galofré, E Grande, C Zafón Llopis, T Ramón Y Cajal Asensio, E Navarro González, P Jiménez-Fonseca, J Santamaría Sandi, J M Gómez Sáez, G Riesco Eizaguirre
Thyroid cancer is the single most prevalent endocrine malignancy; differentiated thyroid cancer (DTC) accounts for more than 90 % of all malignancies and its incidence has been rising steadily. For more patients, surgical treatment, radioactive iodine (RAI) ablation, and thyroid-stimulating hormone (TSH) suppressive therapy achieve an overall survival (OS) rate of 97.7 % at 5 years. Nevertheless, locoregional recurrence occurs in up to 20 % and distant metastases in approximately 10 % at 10 years. Two-thirds of these patients will never be cured with radioactive iodine therapy and will become RAI-refractory, with a 3-year OS rate of less than 50 %...
October 4, 2016: Clinical & Translational Oncology
Adina Elena Stanciu, Anca Elena Hurduc, Marcel Marian Stanciu
OBJECTIVE: We aimed to investigate the effects of thyroid hormone withdrawal on N-terminal prohormone forms of atrial natriuretic peptide (NT-proANP) and brain natriuretic peptide (NT-proBNP) during radioiodine therapy in female patients with differentiated thyroid cancer (DTC). METHODS: Serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), NT-proANP and NT-proBNP were measured in 51 female patients with DTC (48.7 ± 4.2 years) at three time-points: day of radioiodine therapy (t1 - under acute hypothyroidism), 5 days after radioiodine (t2 - under acute hypothyroidism) and 3 months after radioiodine (t3 - under TSH suppression)...
September 26, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
Ramamoorthy Ravichandran, Naima Al Balushi
Radioactive(131) iodine (RAI) body burden is estimated in thyroid cancer patients by a) exposure rate meter and b) external probe counting. A calibration factor of 301 cpm/MBq (d = 16 cm) is used for the probe for estimates of whole body activity. Patients sit in a rotating stool with their center corresponding to the field of view for estimation of whole body RAI. Radioactive counts are obtained for anterio posterior (AP) and postero anterior (PA) geometries. Whole body retention factor is expressed as a ratio against assayed activity administered to the patient on day 1...
September 2016: World Journal of Nuclear Medicine
Nunzia Brusca, Camilla Virili, Miriam Cellini, Silvia Capriello, Lucilla Gargano, Rita Salvatori, Marco Centanni, Maria Giulia Santaguida
OBJECTIVE: Autonomously functioning thyroid areas may be associated with subclinical or overt hyperthyroidism, but may exist even in the presence of normal TSH. This study was aimed at comparing the rate of autonomously functioning areas and their cardiac sequelae in patients with nodular goitre studied with the usual and a novel approach. DESIGN AND METHODS: A total of 490 adult outpatients with thyroid nodular goitre, living in a mild iodine-deficient area, were selected in our Referral Center for thyroid diseases from 2009 to 2014 on the basis of a suspicion of thyroid functional autonomy...
September 19, 2016: European Journal of Endocrinology
Luca Giovanella, Federica D'Aurizio, Alfredo Campenni', Rosaria Maddalena Ruggeri, Sergio Baldari, Frederik Anton Verburg, Pierpaolo Trimboli, Luca Ceriani
The purpose of this study is to evaluate the distribution of thyrotropin (TSH) values in patients with autonomously functioning thyroid nodules and to set a TSH threshold above which thyroid scintigraphy would be obviated. Four hundred fifty one patients were included in the present study. Inclusion criteria were age > 18 years, TSH levels between 0.40 and 4.0 mIU/L, detection of a single solid or predominantly solid thyroid nodule >10 mm in the longest diameter. Thyroid ultrasound and thyroid scintigraphy with (99m)Tc-pertechnetate were performed concurrently in all patients...
September 15, 2016: Endocrine
Haidong Cai, Yu Qiao, Xiao Huang, Ming Sun, Qiong Luo, Xueyu Yuan, Yuehua Yang, Weiqing Mao, Zhongwei Lv
OBJECTIVE: In the initial assessment of thyroid nodules, thyrotropin (TSH) has very low sensitivity for assessing functional thyroid nodules (FTNs). The false negativity in FTNs and the false positivity in non-FTNs misinterpreted by TSH will raise unnecessary assessment costs. Therefore, the aim of this study is to explore the values of the TSH and color flow Doppler sonography (CFDS) combined strategies in reducing the unnecessary assessment costs. METHODS: 2383 patients with thyroid nodules were retrospectively analyzed, including 107 FTNs and 2276 non-FTNs...
September 13, 2016: Annals of Nuclear Medicine
Markus-Johann Dechant, Natascha van der Werf-Grohmann, Elena Neumann, Ute Spiekerkoetter, Brigitte Stiller, Jochen Grohmann
BACKGROUND: Cardiac catheterisation requiring the use of contrast medium is increasingly utilised in infants with congenital heart disease. Thyroid function in infants is potentially vulnerable to relatively high doses of iodine. METHODS: Single-centre prospective study of 21 patients (10 neonates, 11 infants) exposed to iodine during cardiac catheterisation. Median age was 30days (1-180), median body weight 3.3kg (1.6-7.0). Serum-levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) were measured at baseline before, and at three different times points after intervention...
November 15, 2016: International Journal of Cardiology
Haidong Cai, Yu Qiao, Hao Xi, Ming Sun, Qiong Luo, Xueyu Yuan, Yuehua Yang, Zhongwei Lv
OBJECTIVE: The use of thyrotropin (TSH) in the initial assessment of thyroid nodules is inefficient and leads to unnecessary assessment costs. We compared the total costs of thyroid nodule assessment with or without the use of TSH in the initial assessment. METHODS: 1808 patients with thyroid nodules received TSH, fine-needle aspiration (FNA) and thyroid scintigraphy (TS) assessment, including 83 autonomously functioning thyroid nodule (AFTN) cases and 1725 non-AFTN cases...
September 1, 2016: Clinical Endocrinology
Min Jhi Kim, Jandee Lee, Seul Gi Lee, Jung Bum Choi, Tae Hyung Kim, Eun Jeong Ban, Cho Rok Lee, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Young Suk Jo, Woong Youn Chung
BACKGROUND: Robotic modified radical neck dissection (MRND) using a gasless transaxillary approach has been reported to be a safe and meticulous technique in patients with papillary thyroid carcinoma (PTC) and lateral neck node metastasis (N1b). Few studies, however, have attempted to assess the long-term oncologic outcomes of robotic MRND in these patients. This study aimed to compare perioperative and 5-year oncologic outcomes of robotic MRND with conventional open procedures in patients with N1b PTC...
August 29, 2016: Surgical Endoscopy
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