keyword
MENU ▼
Read by QxMD icon Read
search

TSH AND Iodine

keyword
https://www.readbyqxmd.com/read/29771756/thyrotropin-receptor-antibodies-an-overview
#1
Anupam Kotwal, Marius Stan
PURPOSE: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. METHODS: We reviewed and analyzed the literature reporting TRAb assays and their clinical utility...
May 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29759035/a-novel-missense-mutation-in-slc5a5-gene-in-a-sudanese-family-with-congenital-hypothyroidism
#2
Yui Watanabe, Reham Shareef Ebrhim, Mohamed A Abdullah, Roy E Weiss
Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). The proposita is a 28-year-old female whose origin is the North Sudan where neonatal screening for CH is not available. She presented with severe constipation and a goiter at the age of 40 days. Laboratory testing confirmed CH and she was started on levothyroxine (L-T4)...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29754056/nitric-oxide-is-involved-in-the-hypothyroidism-with-significant-morphology-changes-in-female-wistar-rats-induced-by-chronic-exposure-to-high-water-iodine-from-potassium-iodate
#3
Shengzhong Rong, Yanhui Gao, Yanmei Yang, Hanwen Shao, Akinkunmi Paul Okekunle, Chunpeng Lv, Yang Du, Hongna Sun, Yuting Jiang, Gottfried M Darko, Dianjun Sun
Epidemiological studies indicated that chronic exposure to high water iodine is associated with primary hypothyroidism (PH) and subclinical hypothyroidism (SCH). However, the mechanism is not well understood. In this study, we explored whether chronic exposure to high water iodine from potassium iodate (KIO3 ) can induce hypothyroidism in addition to determining if nitric oxide (NO) is involved in the pathogenesis. 96 female Wistar rats were divided into six groups: control, I1000μg/L , I3000μg/L , I6000μg/L , N-nitro-L-arginine methylester (L-NAME) and L-NAME+I6000μg/L ...
May 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29742982/the-nfe2-related-transcription-factor-2-nrf2-coordinates-antioxidant-defense-with-thyroglobulin-production-and-iodination-in-the-thyroid-gland
#4
Panos G Ziros, Ioannis Habeos, Dionysios V Chartoumpekis, Eleni Ntalampyra, Emmanuel Somm, Cédric O Renaud, Massimo Bongiovanni, Ioannis P Trougakos, Masayuki Yamamoto, Thomas W Kensler, Pilar Santisteban, Nancy Carrasco, Carrie Ris-Stalpers, Elena Amendola, Xiao-Hui Liao, Luciano Rossich, Lisa Thomasz, Guillermo Juan Juvenal, Samuel Refetoff, Gerasimos P Sykiotis
BACKGROUND: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation in order to maintain normal function. Although antioxidant and detoxification enzymes presumably aid thyroid cells to maintain homeostasis by ameliorating oxidative insults, including under conditions of exposure to excess iodide, the factors that coordinate their expression with the cellular redox status are not known...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29737268/evaluation-and-management-of-the-child-with-hypothyroidism
#5
Alexander A C Leung, Alexander K C Leung
BACKGROUND: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "hypothyroidism"...
May 8, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29737233/excessive-iodine-intake-and-subclinical-hypothyroidism-in-children-and-adolescents-aged-6-19-years-results-of-the-sixth-korean-national-health-and-nutrition-examination-survey-knhanes-2013-2015
#6
Min Jae Kang, Il Tae Hwang, Hye Rim Chung
BACKGROUND: Iodine is an important element for the thyroid hormone production, and its deficiency or excessive intake is associated with various thyroid diseases. Little is known about the association between iodine status and thyroid function among children and adolescents living in iodine-rich areas, therefore, we analyzed this association using data from a nationwide survey. METHODS: From the Korea National Health and Nutrition Examination Surveys (KNHANES) VI (2013-2015) data, 1288 subjects (711 male) aged 6-19 years who underwent urinary iodine concentration (UIC) test and 1000 subjects (564 male) aged 10-19 years who underwent thyroid function test were included in this study...
May 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29708883/graves-disease-following-allogenic-hematopoietic-stem-cell-transplantation-for-severe-aplastic-anemia-case-report-and-literature-review
#7
Ahu Paketçi, Korcan Demir, Özlem Tüfekçi, Sezer Acar, Ayhan Abacı, Şebnem Yılmaz, Ece Böber
BACKGROUND: Similar autoimmune processes (defective T-cell function) take place during the pathogenesis of aplastic anemia (AA) and Graves' disease (GD). Antithyroid drugs used for the management of GD may induce AA and GD may occur following treatment of severe aplastic anemia (SAA). CASE PRESENTATION: Clinical and laboratory investigations were performed for an 11-year-and-2-month-old girl who was referred for bilateral exophthalmus and abnormal thyroid function tests...
April 25, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29700318/iron-deficiency-is-associated-with-hypothyroxinemia-and-hypotriiodothyroninemia-in-the-spanish-general-adult-population-di-bet-es-study
#8
Cristina Maldonado-Araque, Sergio Valdés, Ana Lago-Sampedro, Juan Antonio Lillo-Muñoz, Eduardo Garcia-Fuentes, Vidal Perez-Valero, Carolina Gutierrez-Repiso, Albert Goday, Ines Urrutia, Laura Peláez, Alfonso Calle-Pascual, Luis Castaño, Contxa Castell, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Joan Vendrell, Matilde R Chacón, Felipe J Chaves, Federico Soriguer, Gemma Rojo-Martínez
Previous studies have suggested that iron deficiency (ID) may impair thyroid hormone metabolism, however replication in wide samples of the general adult population has not been performed. We studied 3846 individuals free of thyroid disease, participants in a national, cross sectional, population based study representative of the Spanish adult population. Thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) were analyzed by electrochemiluminescence (E170, Roche Diagnostics)...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700098/high-prevalence-of-iodine-deficiency-in-pregnant-women-living-in-adequate-iodine-area
#9
Veronica Carneiro Borges Mioto, Ana Carolina Castro Nassif Gomes Monteiro, Rosalinda Y A Camargo, Andreia Rodrigues Borel, Regina Maria Catarino, Sergio Kobayashi, Maria Cristina Chammas, Suemi Marui
INTRODUCTION: Iodine deficiency during pregnancy is associated with obstetrical and neonatal adverse outcomes. Serum thyroglobulin (sTg) and thyroid volume (TV) are optional tools to urinary iodine concentration (UIC) for defining iodine status. This cross sectional study aims to evaluate the iodine status of pregnant women living in iodine-adequate area by spot UIC and correlation with sTg, TV and thyroid function. METHODS: 273 pregnant women were evaluated at three trimesters...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29699957/iodine-deficiency-in-pregnant-women-at-first-trimester-in-ankara
#10
Kazibe Koyuncu, Batuhan Turgay, Feride Söylemez
OBJECTIVE: Iodine deficiency in pregnant woman in Ankara was shown in previous studies. We aimed to conduct a study in a tertiary center to investigate for the need for iodine replacement in our population. MATERIAL AND METHODS: This was a single tertiary center, non-interventional, retrospective, cross-sectional study. Data were retrieved retrospectively from 440 women who had been in first trimester in gestational age. Maternal iodine status, TSH levels, T4 levels were examined...
April 27, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29650436/iodine-nutrition-status-and-prevalence-of-abnormal-tsh-levels-in-schoolchildren-aged-6-7-years-in-the-autonomous-community-of-the-basque-country
#11
Juan José Arrizabalaga, Mercedes Jalón, Mercedes Espada, Mercedes Cañas, José María Arena, Lluís Vila
INTRODUCTION: An epidemiological study conducted between 1988 and 1992 showed iodine deficiency and endemic goiter in the schoolchildren of the autonomous community of the Basque Country. OBJECTIVES: 1) To ascertain the iodine nutrition status of schoolchildren aged 6-7 years, and 2) to estimate the prevalence of abnormal TSH levels in capillary blood. POPULATION AND METHODS: The study was conducted on 497 schoolchildren selected by random sampling...
April 10, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29650270/radioiodine-refractory-differentiated-thyroid-cancer
#12
REVIEW
Yuchen Jin, Douglas Van Nostrand, Lingxiao Cheng, Min Liu, Libo Chen
Differentiated thyroid cancer (DTC) is usually curable with surgery, radioactive iodine (RAI), and thyroid-stimulating hormone (TSH) suppression. However, local recurrence and/or distant metastases occur in approximately 15% of cases during follow-up, and nearly two-thirds of these patients will become RAI-refractory (RR-DTC) with a poor prognosis. This review focuses on the most challenging and rapidly evolving aspects of RR-DTC, and we discuss the considerable improvement in more accurately defining RR-DTC, more effective therapeutic strategies, and describe the diagnosis, pathogenesis, and future prospects of RR-DTC...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29644934/management-of-subclinical-hypothyroidism-in-pregnancy-a-comment-from-the-italian-society-of-endocrinology-sie-and-the-italian-thyroid-association-ait-to-the-2017-ata-guidelines-the-italian-way
#13
Mario Rotondi, Luca Chiovato, Furio Pacini, Luigi Bartalena, Paolo Vitti
The 2017 ATA Guidelines for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum were published six years after the previous ones. They provide comprehensive clinical recommendations for the whole spectrum of thyroid diseases as well as for optimal iodine intake during pregnancy, post-partum and lactation. The present position statement mainly regards the recommended flow-chart for therapeutic decision making in pregnant women being diagnosed with subclinical hypothyroidism. The major biochemical and clinical situations and the corresponding therapeutic indications will be commented...
April 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29624097/positive-thyrotropin-receptor-antibodies-in-patients-with-transient-thyrotoxicosis
#14
Trevor E Angell, Olivia Van Benschoten, David A Cohen, Andrea V Haas, Erik K Alexander, Ellen Marqusee
OBJECTIVE: Thyrotropin (TSH) receptor antibody (TRAb) testing is considered accurate for the diagnosis of Graves' disease (GD), and had been identified rarely in thyrotoxic patients without GD. We describe four patients with transient thyrotoxicosis and positive TRAb to highlight this clinical possibility. METHODS: Patient demographics, symptoms, laboratory findings, and time to resolution of thyrotoxicosis are summarized. TRAb testing was performed by either a third-generation thyrotropin binding inhibitory immunoglobulin competitive binding assay (TBII) or a thyroid stimulating antibody bioassay (TSI) from either Mayo Clinic Laboratory or Quest Diagnostics...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29604104/serum-thyroid-stimulating-hormone-levels-and-smoking-status-data-from-the-korean-national-health-and-nutrition-examination-survey-vi
#15
Suyeon Park, Won Gu Kim, Min Ji Jeon, Mijin Kim, Hye-Seon Oh, Minkyu Han, Tae Yong Kim, Young Kee Shong, Won Bae Kim
OBJECTIVE: We aimed to evaluate differences in serum thyroid-stimulating hormone (TSH) levels according to smoking status and urine iodine concentration (UIC) in a healthy Korean population using data from the Sixth Korean National Health and Nutrition Examination Survey (KNHANES VI). STUDY DESIGN: Sixth Korean National Health and Nutrition Examination Survey (2013-2015) is a nationwide, cross-sectional survey of the Korean population. PATIENTS: Research subjects were selected by two-stage stratified cluster sampling of the population and housing census data...
March 31, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29594050/ultrasound-measurements-of-thyroid-gland-volume-at-36-weeks-corrected-gestational-age-in-extremely-preterm-infants-born-before-28-weeks-gestation
#16
Sze May Ng, Mark A Turner, Shivaram Avula
Background: Thyroid ultrasound is a non-invasive imaging tool and provides good evaluation of thyroid anatomy, location, vascularisation, and echogenicity. The aim of this study was to assess thyroid function and thyroid volume in extremely preterm infants born before 28 weeks' gestation evaluated at 36 weeks' corrected gestational age (CGA) compared to term infants' normative data in the literature. Design: In this largest prospective UK study of extremely premature infants born at less than 28 weeks' gestation, thyroid volume measurement was assessed at 36 weeks' CGA...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29592779/the-associations-of-urinary-cotinine-verified-active-and-passive-smoking-with-thyroid-function-analysis-of-population-based-nationally-representative-data
#17
Jihun Kang, Eunhee Kong, Jongsoon Choi
BACKGROUND: The effects of active and passive smoking on thyroid function in the Korean population have not been determined. Furthermore, related research is based on self-reported smoking status, which may be inaccurate, especially among women. The present study aimed to evaluate the association between biochemically verified smoking status and thyroid function in a nationally representative Korean population. METHODS: This population-based cross-sectional study included 3,404 subjects without thyroid disease and who were not taking thyroid medication...
March 28, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29590674/-influence-of-glucocorticoid-therapy-on-intratherapeutic-biodistribution-of-131i-radioiodine-therapy-in-graves-disease
#18
Jörg Halstenberg, Wolfgang Tilman Kranert, Hüdayi Korkusuz, Amelie Mayer, Hanns Ackermann, Frank Grünwald, Christian Happel
AIM: Radioiodine therapy (RIT) is an important therapeutic method in the definitive treatment of Graves' disease (GD). However, RIT may trigger development of Graves' ophthalmopathy (GO) or exacerbate a pre-existing GO. Therefore, the procedure recommendation of the DGN (German Society of Nuclear Medicine) for RIT of benign thyroid diseases recommends an additional glucocorticoid therapy for patients with pre-existing GO. Aim of this study was to analyze the influence of a protective glucocorticoid therapy on131 I biokinetics during RIT of patients with GD...
April 2018: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29569122/impact-of-maternal-thyroid-autoantibodies-positivity-on-the-risk-of-early-term-birth-ma-anshan-birth-cohort-study
#19
Yan Han, Lei-Jing Mao, Xing Ge, Kun Huang, Shuang-Qin Yan, Ling-Ling Ren, Shu-Qing Hong, Hui Gao, Jie Sheng, Yuan-Yuan Xu, Wei-Jun Pan, Peng Zhu, Jia-Hu Hao, De-Fa Zhu, Fang-Biao Tao
PURPOSE: We aim to investigate associations of maternal serum anti-thyroperoxidase autoantibody (TPOAb) with duration of gestation. We aim to investigate whether maternal TPOAb positivity is associated with the risk of premature or early term birth. METHODS: This was a prospective birth cohort study performed in an iodine sufficient area of China. Serum samples were collected from 2931 women at both the first and second trimesters of pregnancy. Thyrotropin (TSH), free thyroxine (FT4), and TPOAb levels were measured...
March 22, 2018: Endocrine
https://www.readbyqxmd.com/read/29546542/association-of-tshr-gene-copy-number-variation-with-tsh-abnormalities
#20
Yi Pang, Yunfeng Guan, Xing Jin, Hongmei Shen, Lixiang Liu, Qingzhen Jia, Fangang Meng, Xiaoye Zhang
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. By consulting the literature, we found that the TSHR, PAX8, and PDE4B genes are associated with thyroid function. Recently, copy number variations (CNVs) have been used as genetic markers to investigate inter-individual variation. Therefore, we investigated the relationship between the TSHR, PAX8, and PDE4B gene CNVs and TSH abnormalities, by calculating variations in gene copy number...
March 15, 2018: Biological Trace Element Research
keyword
keyword
80229
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"