keyword
MENU ▼
Read by QxMD icon Read
search

TSH AND T4

keyword
https://www.readbyqxmd.com/read/29768692/prevalence-of-subclinical-hypothyroidism-in-obese-children-or-adolescents-and-association-between-thyroid-hormone-and-the-components-of-metabolic-syndrome
#1
Hye Young Jin
AIM: Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones. METHODS: A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI...
May 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29763838/the-overweight-increases-circulating-inflammatory-mediators-commonly-associated-with-obesity-in-young-individuals
#2
Laís Roquete Lopes, Silvana Mara Luz Turbino Ribeiro, Vivian Paulino Figueiredo, Ana Luísa Junqueira Leite, Roney Luiz de Carvalho Nicolato, Juliana Assis Estanislau Gomes, Fernando Luiz Pereira de Oliveira, Andre Talvani
Obesity is a serious and growing world healthy problem affecting developed and developing countries. The new conception of obesity as a basal inflammatory condition has opened a new window of possibilities to identify inflammatory biomarkers to be used in the diagnosis or prognosis of obesity-associated comorbidities. This present work aims the identification of the adipokines (leptin and resistin), chemokines (CCL2, CCL5, CXCL16) and the BMP-2 and their association with the clinical, biochemical (fasting glucose, hemogram, cholesterol, T3, T4 and TSH) and anthropometric (weight, height, body circumferences, skinfold thickness and percentage of body fat) parameters in young adults (18-30 years old) presenting obesity and overweight...
May 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29759035/a-novel-missense-mutation-in-slc5a5-gene-in-a-sudanese-family-with-congenital-hypothyroidism
#3
Yui Watanabe, Reham Shareef Ebrhim, Mohamed A Abdullah, Roy E Weiss
Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). The proposita is a 28-year-old female whose origin is the North Sudan where neonatal screening for CH is not available. She presented with severe constipation and a goiter at the age of 40 days. Laboratory testing confirmed CH and she was started on levothyroxine (L-T4)...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29748035/direct-correlation-between-serum-homocysteine-level-and-insulin-resistance-index-in-patients-with-subclinical-hypothyroidism-does-subclinical-hypothyroidism-increase-the-risk-of-diabetes-and-cardio-vascular-disease-together
#4
Anahita Ebrahimpour, Mostafa Vaghari-Tabari, Durdi Qujeq, Soheila Moein, Zoleikha Moazezi
BACKGROUND: Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue. METHODS AND MATERIALS: Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group...
May 5, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29746532/association-between-perfluoroalkyl-substances-exposure-and-thyroid-function-in-adults-a-meta-analysis
#5
Min Joo Kim, Shinje Moon, Byung-Chul Oh, Dawoon Jung, Kyunghee Ji, Kyungho Choi, Young Joo Park
OBJECTIVE: Many people are exposed to perfluoroalkyl substances (PFASs) because these substances are widely used as industrial products. Although epidemiological studies suggest that PFASs can disrupt thyroid hormones, the association between PFAS exposure and thyroid function remains inconclusive. Therefore, we performed a comprehensive meta-analysis to investigate the association between PFASs exposure and thyroid hormones. METHODS: We searched medical literature databases for articles on the association between PFASs-perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS)-and thyroid hormone levels in adults...
2018: PloS One
https://www.readbyqxmd.com/read/29737268/evaluation-and-management-of-the-child-with-hypothyroidism
#6
Alexander A C Leung, Alexander K C Leung
BACKGROUND: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "hypothyroidism"...
May 8, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29737233/excessive-iodine-intake-and-subclinical-hypothyroidism-in-children-and-adolescents-aged-6-19-years-results-of-the-sixth-korean-national-health-and-nutrition-examination-survey-knhanes-2013-2015
#7
Min Jae Kang, Il Tae Hwang, Hye Rim Chung
BACKGROUND: Iodine is an important element for the thyroid hormone production, and its deficiency or excessive intake is associated with various thyroid diseases. Little is known about the association between iodine status and thyroid function among children and adolescents living in iodine-rich areas, therefore, we analyzed this association using data from a nationwide survey. METHODS: From the Korea National Health and Nutrition Examination Surveys (KNHANES) VI (2013-2015) data, 1288 subjects (711 male) aged 6-19 years who underwent urinary iodine concentration (UIC) test and 1000 subjects (564 male) aged 10-19 years who underwent thyroid function test were included in this study...
May 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29734584/longitudinal-assessment-of-prenatal-phthalate-exposure-on-serum-and-cord-thyroid-hormones-homeostasis-during-pregnancy-tainan-birth-cohort-study-tbcs
#8
Han-Bin Huang, Pao-Lin Kuo, Jung-Wei Chang, Jouni J K Jaakkola, Kai-Wei Liao, Po-Chin Huang
An increasing number of studies have revealed that phthalate exposure alters thyroid hormone homeostasis in the general population, but there is insufficient evidence of the effect of longitudinal maternal phthalate exposure on maternal and fetal thyroid hormones during pregnancy. We longitudinally assessed the effect of prenatal phthalate exposure in pregnant women on umbilical cord and maternal thyroid hormones at three trimesters during pregnancy. We recruited 98 pregnant women and collected urine and blood samples at three trimesters in an obstetrics clinic in Southern Taiwan from 2013 to 2014...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29733970/thyroxine-binding-globulin-deficiency-due-to-a-novel-serpina7-mutation-clinical-characterization-analysis-of-x-chromosome-inactivation-pattern-and-protein-structural-modeling
#9
Cristiane Jeyce Gomes Lima, Andressa Aby Faraj Linhares Maciel, Matheus de Oliveira Andrade, Vinicius Santos da Cunha, Juliana Forte Mazzeu, Lucas Bleicher, Francisco de Assis Rocha Neves, Adriana Lofrano-Porto
OBJECTIVE: Thyroxine-binding globulin (TBG) is the major human thyroid hormone transport protein, encoded by the SERPINA7 gene (Xq22.2). We aim to investigate the molecular basis of partial TBG deficiency (TBG-PD) in a female, by evaluating the X-chromosome inactivation pattern as well as the mutant protein structural modeling. DESIGN AND METHODS: Sequencing of the coding region of the SERPINA7 gene was performed in a female with a TBG-PD phenotype and her first-degree relatives...
May 4, 2018: Gene
https://www.readbyqxmd.com/read/29720960/increased-requirement-of-replacement-doses-of-levothyroxine-caused-by-liver-cirrhosis
#10
Salvatore Benvenga, Giovanni Capodicasa, Sarah Perelli, Silvia Martina Ferrari, Poupak Fallahi, Alessandro Antonelli
Background: Since hypothyroidism is a fairly common dysfunction, levothyroxine (L-T4) is one of the most prescribed medications. Approximately 70% of the administered L-T4 dose is absorbed. The absorption process takes place in the small intestine. Some disorders of the digestive system and some medicines, supplements, and drinks cause L-T4 malabsorption, resulting in failure of serum TSH to be normal. Only rarely liver cirrhosis is mentioned as causing L-T4 malabsorption. Case report: In this study, we report increased requirement of daily doses of l-thyroxine in two patients with the atrophic variant of Hashimoto's thyroiditis and liver cirrhosis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29720101/a-novel-mutation-in-the-tg-gene-g2322s-causing-congenital-hypothyroidism-in-a-sudanese-family-a-case-report
#11
Y Watanabe, E Sharwood, B Goodwin, M K Creech, H Y Hassan, M G Netea, M Jaeger, A Dumitrescu, S Refetoff, T Huynh, R E Weiss
BACKGROUND: Congenital hypothyroidism (CH) has an incidence of approximately 1:3000, but only 15% have mutations in the thyroid hormone synthesis pathways. Genetic analysis allows for the precise diagnosis. CASE PRESENTATION: A 3-week old girl presented with a large goiter, serum TSH > 100 mIU/L (reference range: 0.7-5.9 mIU/L); free T4  < 3.2 pmol/L (reference range: 8.7-16 pmol/L); thyroglobulin (TG) 101 μg/L. Thyroid Tc-99 m scan showed increased radiotracer uptake...
May 2, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29715188/possible-protective-effect-of-curcumin-on-the-thyroid-gland-changes-induced-by-sodium-fluoride-in-albino-rats-light-and-electron-microscopic-study
#12
Mohamed Mostafa Abdelaleem, Nashwa Fathy Gamal El-Tahawy, Samah Mohammed Mahmoud Abozaid, Shima Abdel-Baset Abdel-Hakim
OBJECTIVES: Thyroid gland regulates the body's metabolic rate and plays an exquisitely important role in the human health. Fluoride exposure can affect thyroid function. Curcumin is a potent antioxidant that works through several mechanisms. The aim of the present study was to demonstrate the hormonal, histological, and ultrastructural changes occurred in the thyroid gland induced by exposure to sodium fluoride (NaF) and study the possible protective effect of curcumin on the NaF-induced effects...
April 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29713225/utility-of-quantitative-parameters-from-single-photon-emission-computed-tomography-computed-tomography-in-patients-with-destructive-thyroiditis
#13
Ji-Young Kim, Ji Hyun Kim, Jae Hoon Moon, Kyoung Min Kim, Tae Jung Oh, Dong-Hwa Lee, Young So, Won Woo Lee
Objective: Quantitative parameters from Tc-99m pertechnetate single-photon emission computed tomography/computed tomography (SPECT/CT) are emerging as novel diagnostic markers for functional thyroid diseases. We intended to assess the utility of SPECT/CT parameters in patients with destructive thyroiditis. Materials and Methods: Thirty-five destructive thyroiditis patients (7 males and 28 females; mean age, 47.3 ± 13.0 years) and 20 euthyroid patients (6 males and 14 females; mean age, 45...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29699957/iodine-deficiency-in-pregnant-women-at-first-trimester-in-ankara
#14
Kazibe Koyuncu, Batuhan Turgay, Feride Söylemez
OBJECTIVE: Iodine deficiency in pregnant woman in Ankara was shown in previous studies. We aimed to conduct a study in a tertiary center to investigate for the need for iodine replacement in our population. MATERIAL AND METHODS: This was a single tertiary center, non-interventional, retrospective, cross-sectional study. Data were retrieved retrospectively from 440 women who had been in first trimester in gestational age. Maternal iodine status, TSH levels, T4 levels were examined...
April 27, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29692575/asymptomatic-thyroid-dysfunction-in-human-immunodeficiency-virus-1-infected-subjects
#15
Mathias Abiodun Emokpae, Imwonghomwen Mercy Akinnuoye
BACKGROUND: Thyroid hormone abnormalities have been reported elsewhere in human immunodeficiency virus-1 (HIV-1)-infected individuals, but such studies in Nigerians are scarce in literature. OBJECTIVE: To evaluate thyroid function in HIV-1-infected individuals and to correlate thyroid function parameters with cluster of differentiation (CD4+ ) cell count. MATERIALS AND METHODS: Total thyroxine (T4), total triiodothyronine (T3), thyroid-stimulating hormone (TSH), and CD4+ were estimated in 100 HIV-1-positive individuals on highly active antiretroviral therapy (HAART), 100 HIV-1-positive HAART naïve, and 100 HIV-1-negative controls...
April 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29686704/the-change-of-left-ventricular-function-in-rats-with-subclinical-hypothyroid-and-the-effects-of-thyroxine-replacement
#16
Xuedi Chen, Cuixia Gao, Ningning Gong, Yu Wang, Limin Tian
Objective: The main purpose of this study was to explore the relationships between serca2a, Ryr2, adipokines, and the left ventricular function in the subclinical hypothyroidism with different TSH levels and to determine the impact of L-T4 treatment on these indexes. Methods: Sixty-five male Wistar rats were randomly divided into five groups: control group; sHT A, B, and C group; and sHT + T4 group. The sHT rats were induced by methimazole (MMI), and the sHT + T4 rats were administered with L-T4 treatment after 8 weeks of MMI administration...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29684825/exposure-to-polybrominated-diphenyl-ethers-and-phthalates-in-healthy-men-living-in-the-greater-montreal-area-a-study-of-hormonal-balance-and-semen-quality
#17
Océane Albert, Jonathan Y Huang, Katarina Aleksa, Barbara F Hales, Cynthia G Goodyer, Bernard Robaire, Jonathan Chevrier, Peter Chan
Studies investigating the associations between exposure of young men to polybrominated diphenyl ethers (PBDEs) or phthalates and hormone levels or semen quality have produced inconsistent results. Our goal was to investigate the association of exposure to PBDEs or phthalate metabolites with changes in markers of thyroid (TSH, free T3 and free T4) and reproductive function (sperm concentrations, motility, and quality; serum LH and testosterone) in 153 healthy young men from the greater Montreal area. Using covariate-adjusted models, we found that each 10-fold increase in BDE-47 was associated with lower TSH levels (-17...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29674996/association-between-thyroid-hormones-thyroid-antibodies-and-cardiometabolic-factors-in-non-obese-individuals-with-normal-thyroid-function
#18
Jia Liu, Yan Duan, Jing Fu, Guang Wang
Background: Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29665650/selenium-nanoparticles-prevents-lead-acetate-induced-hypothyroidism-and-oxidative-damage-of-thyroid-tissues-in-male-rats-through-modulation-of-selenoenzymes-and-suppression-of-mir-224
#19
Hebatallah Husseini Atteia, Manar Hamed Arafa, Kousalya Prabahar
Selenium nanoparticles (Se-NPs) are customizable drug delivery vehicles that show good bioavailability, higher efficacy and lower toxicity than ordinary Se. Pre-treatment of male rats with these NPs has been recently shown to exert a protective effect against chromium-induced thyroid dysfunction. This study, therefore, aimed to investigate and characterize the potential protective mechanism of Se-NPs against lead (Pb) acetate-induced thyrotoxicity. We found that prophylactic and concurrent treatment of Pb acetate-exposed rats with Nano-Se (0...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664655/short-term-assessment-of-hsct-effects-on-the-hypothalamus-pituitary-axis-in-pediatric-thalassemic-patients
#20
Amir Ali Hamidieh, Fariba Mohseni, Maryam Behfar, Zohreh Hamidi, Kamran Alimoghaddam, Mohamad Pajouhi, Bagher Larijani, Mohammad-Reza Mohajeri-Tehrani, Ardeshir Ghavamzadeh
BACKGROUND: Beta thalassemia major (BTM) and its treatment by hematopoietic stem cell transplantation (HSCT) may have deleterious effects on the endocrine systems. We assessed endocrine complications of HSCT in pediatric patients for 3 months. METHODS: In 20 (6 female) pediatric major thalassemic patients (mean age of 10.8 ± 3.9 years old), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), T4, T3, thyroid-stimulating hormone (TSH), IGF-1, testosterone (in males) or estradiol (in females) were measured as a batch at the Endocrinology and Metabolism Research Center (EMRC) of Tehran University of Medical Sciences (TUMS) laboratories before HSCT and 1 and 3 months afterwards...
February 1, 2018: Archives of Iranian Medicine
keyword
keyword
80228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"