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https://www.readbyqxmd.com/read/28336316/effects-of-age-and-soybean-isoflavones-on-hepatic-cholesterol-metabolism-and-thyroid-hormone-availability-in-acyclic-female-rats
#1
Branka Šošić-Jurjević, Dieter Lütjohann, Ivana Jarić, Marko Miler, Danijela Vojnović Milutinović, Branko Filipović, Vladimir Ajdžanović, Kostja Renko, Eva Katrin Wirth, Snežana Janković, Josef Kӧhrle, Verica Milošević
Soy-food and its isoflavones, genistein (G) and daidzein (D), were reported to exert mild cholesterol-lowering effect, but the underlying mechanism is still unclear. In this research, first we studied age-related alterations in hepatic cholesterol metabolism of acyclic middle-aged (MA) female rats. Then we tested if purified isoflavones may prevent or reverse these changes, and whether putative changes in hepatic thyroid hormone availability may be associated with this effect. Serum and hepatic total cholesterol (TChol), bile acid and cholesterol precursors, as well as serum TSH and T4 concentrations, hepatic deiodinase (Dio) 1 enzyme activity and MCT8 protein expression were determined by comparing data obtained for MA with young adult (YA) intact (IC) females...
March 20, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28333900/-the-influence-of-hypothyroidism-on-the-conversion-and-binding-of-thyroid-hormones-in-patients-with-end-stage-renal-disease
#2
Iwanna Dubczak, Longin Niemczyk, Zbigniew Bartoszewicz, Katarzyna Szamotulska, Marek Saracyn, Stanisław Niemczyk
Hypothyroidism in patients with renal failure (RF) causes many metabolic and clinical problems, and both these diseases can mutually exacerbate their disturbances. AIM: The aim of this study was to evaluate the effect of hypothyroidism, and end-stage renal disease (ESRD) on conversion of thyroid hormones (TH) in patients with ESRD treated with chronic hemodialysis (HD). MATERIALS AND METHODS: The study was performed in 74 patients, including 41 women (K) and 33 men (M) aged 28-83 y...
March 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28333653/association-of-transient-hyperthyroidism-and-severity-of-hyperemesis-gravidarum
#3
Nor Zila Hassan Malek, Aida Kalok, Zainal Abidin Hanafiah, Shamsul Azhar Shah, Nor Azlin Mohamed Ismail
Background Transient non-immune hyperthyroidism in early pregnancy is hyperthyroidism diagnosed for the first time in early pregnancy, without evidence of thyroid autoimmunity or clinical findings of Grave's disease and resolved spontaneously as the pregnancy progressed. Hyperemesis gravidarum (HG) is the commonest cause with 66%-73% of women with severe HG were found to have elevated thyroid function. Materials and methods We conducted a cross sectional study to determine the prevalence of transient hyperthyroidism in patients with hyperemesis gravidarum and its relation to the severity of nausea and vomiting...
March 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28332275/thyroid-dysfunction-in-patients-with-down-syndrome-results-from-a-multi-institutional-registry-study
#4
Jenifer Lavigne, Christianne Sharr, Ibrahim Elsharkawi, Al Ozonoff, Nicole Baumer, Campbell Brasington, Sheila Cannon, Blythe Crissman, Emily Davidson, Jose C Florez, Priya Kishnani, Angela Lombardo, Jordan Lyerly, Mary Ellen McDonough, Alison Schwartz, Kathryn Berrier, Susan Sparks, Kara Stock-Guild, Tomi L Toler, Kishore Vellody, Lauren Voelz, Brian G Skotko
The goals of this undertaking were to assess the outcomes of thyroid screening tests and adherence to thyroid screening guidelines across five Down syndrome (DS) specialty clinics in various states. Data related to thyroid screening were collected for 663 individuals across five clinics specializing in the comprehensive care of individuals with DS for a period of 1 year. Of the 663 participants, 47.7% of participants had a TSH and free T4 ordered at their DS specialty clinic visit. Approximately 19.0% (60/316) had a new thyroid disorder diagnosis made...
March 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327186/clinical-behavioural-and-pharmacogenomic-factors-influencing-the-response-to-levothyroxine-therapy-in-patients-with-primary-hypothyroidism-protocol-for-a-systematic-review
#5
Rosie Dew, Onyebuchi Okosieme, Colin Dayan, Vinay Eligar, Ishrat Khan, Salman Razvi, Simon Pearce, Scott Wilkes
BACKGROUND: Suboptimal thyroid hormone therapy including under-replacement and over-replacement is common amongst patients with hypothyroidism. This is a significant health concern as affected patients are at risk of adverse cardiovascular or metabolic consequences. Despite a growing body of evidence on the effects of various factors on thyroid hormone replacement, a systematic appraisal of the evidence is lacking. This review aims to appraise and quantify the extent to which clinical, behavioural and pharmacogenomic factors affect levothyroxine therapy in patients with primary hypothyroidism...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28325735/rescue-preoperative-treatment-with-lugol-s-solution-in-uncontrolled-graves-disease
#6
Jan Calissendorff, Henrik Falhammar
BACKGROUND: Graves' disease is a common cause of hyperthyroidism. Three therapies have been used for decades: pharmacologic therapy, surgery and radioiodine. In case of adverse events, especially agranulocytosis or hepatotoxicity, pre-treatment with Lugol's solution containing iodine/potassium-iodide to induce euthyroidism before surgery could be advocated but has rarely been reported. METHOD: All patients hospitalised due to uncontrolled hyperthyroidism at the Karolinska University Hospital 2005-2015 and treated with Lugol's solution were included...
March 21, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28324063/dio2-thr92ala-reduces-deiodinase-2-activity-and-serum-t3-levels-in-thyroid-deficient-patients
#7
M G Castagna, M Dentice, S Cantara, R Ambrosio, F Maino, T Porcelli, C Marzocchi, C Garbi, F Pacini, D Salvatore
Context: A significant proportion of athyreotic LT4-treated patients experience hypothyroid-like symptoms. During LT4 replacement, levels of the active hormone triiodothyronine (T3) strictly depend on type-2-deiodinase (D2)-mediated activation of LT4. The Thr92Ala polymorphism and the 258 G/A in the DIO2 gene have been associated with various clinical conditions. Objectives: To investigate the effects of DIO2 polymorphisms in thyroid hormone homeostasis. Design: We compared the pre-surgical hormonal status of thyroidectomized LT4-treated patients who had a similar TSH level, to their post-surgery status, and analyzed their DIO2 genotype in a subgroup of 102/140 (72...
February 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322754/evaluation-of-the-clsi-ep26-a-protocol-for-detection-of-reagent-lot-to-lot-differences
#8
Brooke M Katzman, Karl M Ness, Alicia Algeciras-Schimnich
BACKGROUND: Verification of new reagent lots is a required laboratory task. The Clinical and Laboratory Standards Institute (CLSI) EP26-A guideline provides a lot-to-lot verification protocol to detect significant changes in test performance. The aim of this study was to compare the performance of EP26-A with our laboratory reagent lot verification protocol. METHODS: Prospective evaluations for two reagent lots each for thyroid stimulating hormone (TSH), thyroglobulin (Tg), thyroxine (T4), triiodothyronine (T3), free triiodothyronine (fT3), and thyroid peroxidase antibody (TPOAb) were performed...
March 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28287838/renal-function-improves-with-the-treatment-of-hypothyroidism
#9
Oktay Bulur, Kursat Dal, Derun Taner Ertugrul, Murat Eser, Fatma Kaplan Efe, Serdar Karakaya, Kubilay Şahin, Salih Baser, Naim Ata, Aysun Aybal Kutlugun, Esin Beyan
BACKGROUND: It has been known that thyroid hormones may affect renal function. In this study, we aimed to investigate the effect of levothyroxine replacement on renal function in hypothyroid patients before and after treatment. METHODS: We retrospectively investigated free T3 (fT3), free T4 (fT4), TSH, creatinine, and eGFR measurements during both hypothyroid and euthyroid states of hypothyroid patients. The eGFR was calculated using the simplified Modification of Diet in Renal Disease formula...
March 13, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28285354/endocrine-disruption-oxidative-stress-and-testicular-damage-induced-by-4-nonylphenol-in-clarias-gariepinus-the-protective-role-of-cydonia-oblonga
#10
Alaa El-Din H Sayed, Rania F K Ismail
Exposure to xenoestrogens like 4-nonylphenol (NP) is recognized by disrupting endocrine functions and causes reproductive dysfunction in male fish. The present study aimed at investigating the 4-nonylphenol propensity to induce oxidative stress and hormonal disturbances in male catfish and at studying the protective role of quince (Cydonia oblonga). To fulfill this aim, catfish Clarias gariepinus were exposed to pure 100 μg/L 4-NP and to quince the leaf extract added to 4-NP, both for 15 days. The 4-NP exposure induced a marked increase in 17ß-estradiol (E2), LH, and cortisol, while thyroid hormone (TSH, T3), testosterone (T), and FSH levels noticeably decreased; however, 4-NP had no effect on T4 level...
March 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28285281/relation-of-thyroid-hormone-levels-with-fluid-resistant-shock-among-preterm-septicemic-neonates
#11
Sourabh Dutta, Sarvendra Singh, Anish Bhattacharya, Sundaram Venkataseshan, Praveen Kumar
OBJECTIVE: To compare thyroid hormone levels between septicemic preterm neonates with and without shock. METHODS: Preterm septicemic infants with shock constituted Group A (n=36) and those without shock constituted Group B, with groups matched (1:1) for gestation and postnatal age. Those with maternal thyroid disorders, thyrotropic medication and life expectancy <12 hours were excluded. We compared serum tri-iodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) between the groups by univariate and multivariate (adjusting for SNAPPE-II) analysis...
February 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28267586/maternal-carbamazepine-alters-fetal-neuroendocrine-cytokines-axis
#12
R G Ahmed
This study detected the effects of maternal carbamazepine (CBZ) on the fetal neuroendocrine-cytokines axis. 25 or 50mg/kg of CBZ was intraperitoneally administrated to pregnant rats from gestation day (GD) 1 to 20. In dams and their fetuses, there was an elevation in the values of serum thyrotropin (TSH) which was accompanied by a decrease in the values of serum thyroxine (T4) and triiodothyronine (T3) at GD 20 due to both maternal administrations of CBZ compared to the control group. Also, both administrations had undesirable impacts on the maternal body weight gain, fetal body weight, survival of dams and fetuses, food consumption, and litter weight as compared to the corresponding control group...
March 3, 2017: Toxicology
https://www.readbyqxmd.com/read/28262328/citrus-flavanones-mildly-interfere-with-pituitary-thyroid-axis-in-old-aged-male-rats
#13
Marko Miler, Ivana Jarić, Jasmina Živanović, Vladimir Ajdžanović, Nasta Tanić, Verica Milošević, Branka Šošić-Jurjević
Citrus flavanones naringenin (NAR) and hesperetin (HES) are potent antioxidants that may contribute to maintenance of health at old age by improving cardiovascular and metabolic status. However, they may also affect thyroid hormone economy. Keeping in mind impaired thyroid function at older age, in this study we tested wheather NAR or HES administration potentiate this decline. NAR or HES were administrated orally (15mg/kg) to male 24-month-old Wistar rats during 4 weeks. Control groups received vehicle, sunflower oil...
March 2, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28259898/an-improved-method-for-the-establishment-of-a-model-of-graves-disease-in-balb-c-mice
#14
Wei Zheng, Renfei Wang, Jian Tan, Ning Li, Zhaowei Meng
The present study aimed to develop a stable Graves' disease (GD) model in BALB/c mice by immunization and electroporation (EP). A total of 90 mice were divided into experimental (n=50), control (n=20) and blank (n=20) groups. The recombinant plasmid pcDNA3.1/thyroid‑stimulating hormone (TSH) receptor 268 was constructed and injected into the bilateral gastrocnemius of experimental group mice at weeks 1, 4, 7 and 10. Equal volumes of saline were injected into the control and blank groups at the same time...
February 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28255851/the-impact-of-bariatric-surgery-on-thyroid-function-and-medication-use-in-patients-with-hypothyroidism
#15
Alex Zendel, Yasmin Abu-Ghanem, Joseph Dux, Eyal Mor, Douglas Zippel, David Goitein
BACKGROUND: Bariatric surgery (BS) is effective in treating obesity and its associated comorbidities. However, there is a paucity of data on the effect of BS on thyroid function in hypothyroid patients, specifically in those treated with thyroid hormone replacement therapy (THR). The aim of this study was to assess the effect of BS on thyroid function and on THR dosage in patients with hypothyroidism. METHODS: A retrospective analysis of prospectively collected data of all hypothyroid patients who underwent BS between 2010 and 2014 was performed...
March 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28253303/urinary-metabolomics-reveals-glycemic-and-coffee-associated-signatures-of-thyroid-function-in-two-population-based-cohorts
#16
Nele Friedrich, Maik Pietzner, Claire Cannet, Betina H Thuesen, Torben Hansen, Henri Wallaschofski, Niels Grarup, Tea Skaaby, Kathrin Budde, Oluf Pedersen, Matthias Nauck, Allan Linneberg
BACKGROUND: Triiodothyronine (T3) and thyroxine (T4) as the main secretion products of the thyroid affect nearly every human tissue and are involved in a broad range of processes ranging from energy expenditure and lipid metabolism to glucose homeostasis. Metabolomics studies outside the focus of clinical manifest thyroid diseases are rare. The aim of the present investigation was to analyze the cross-sectional and longitudinal associations of urinary metabolites with serum free T4 (FT4) and thyroid-stimulating hormone (TSH)...
2017: PloS One
https://www.readbyqxmd.com/read/28250654/insulin-plant-costus-pictus-extract-restores-thyroid-hormone-levels-in-experimental-hypothyroidism
#17
S Ashwini, Zachariah Bobby, M G Sridhar, C C Cleetus
BACKGROUND: The aim of the present study was to investigate the preventive effect of Costus pictus leaf extract in experimental hypothyroidism. MATERIALS AND METHODS: Forty male Wistar rats were randomly divided into four groups with ten rats in each group: Control (C), hypothyroid (H), control+extract (C+E), and hypothyroid+extract (H+E). Rats in C group did not receive any intervention throughout the experimental period. The rats in the C+E and H+E groups received pretreatment with C...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28249913/alteration-of-hemostatic-parameters-in-patients-with-different-levels-of-subclinical-hypothyroidism-and-the-effect-of-l-thyroxine-treatment
#18
Fang Gao, Guangya Wang, Jinxiu Xu
Subclinical hypothyroidism (SH) is associated with hypercoagulability and hypofibrinolysis. The objective of this study was to assess the effect of L-thyroxine (L-T4) treatment and to evaluate changes in the hemostatic abnormalities of patients with varying severities of SH. We measured tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), D-dimer (DDI), fibrinogen (FIB), platelet counts (PLT), mean platelet volume (MPV), platelet distribution width (PDW), activated partial thromboplastin time (APTT), and prothrombin time (PT) in 149 female subjects...
January 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28245931/disruption-of-thyroid-hormone-th-levels-and-th-regulated-gene-expression-by-polybrominated-diphenyl-ethers-pbdes-polychlorinated-biphenyls-pcbs-and-hydroxylated-pcbs-in-e-waste-recycling-workers
#19
Jing Zheng, Chun-Tao He, She-Jun Chen, Xiao Yan, Mi-Na Guo, Mei-Huan Wang, Yun-Jiang Yu, Zhong-Yi Yang, Bi-Xian Mai
Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are the primary toxicants released by electronic waste (e-waste) recycling, but their adverse effects on people working in e-waste recycling or living near e-waste sites have not been studied well. In the present study, the serum concentrations of PBDEs, PCBs, and hydroxylated PCBs, the circulating levels of thyroid hormones (THs), and the mRNA levels of seven TH-regulated genes in peripheral blood leukocytes of e-waste recycling workers were analyzed...
February 25, 2017: Environment International
https://www.readbyqxmd.com/read/28237669/disruption-of-the-hypothalamic-pituitary-thyroid-axis-on-co-exposures-to-dithiocarbamate-and-neonicotinoid-pesticides-study-in-a-wildlife-bird-amandava-amandava
#20
Surya Prakash Pandey, Banalata Mohanty
Non-target organisms, including human and wildlife, are susceptible to deleterious effects of pesticide mixtures in their environment. Present study demonstrated the disruption of the hypothalamic-pituitary-thyroid (HPT) axis in a seasonally breeding wildlife bird Amandava amandava on co-exposure to dithiocarbamate mancozeb/MCZ and neonicotinoid imidacloprid/IMI, at concentrations even lower than respective environmentally realistic exposure level of each of the pesticide. Adult male birds (n=8/group) were exposed individually to 0...
February 22, 2017: Neurotoxicology
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