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https://www.readbyqxmd.com/read/28645753/multi-immunoreaction-based-dual-color-capillary-electrophoresis-for-enhanced-diagnostic-reliability-of-thyroid-gland-disease
#1
Nain Woo, Su-Kang Kim, Seong Ho Kang
Thyroid-stimulating hormone (TSH) secretion plays a critical role in regulating thyroid gland function and circulating thyroid hormones (i.e., thyroxine (T4) and triiodothyronine (T3)). A novel multi-immunoreaction-based dual-color capillary electrophoresis (CE) technique was investigated in this study to assess its reliability in diagnosing thyroid gland disease via simultaneous detection of TSH, T3, and T4 in a single run of CE. Compared to the conventional immunoreaction technique, multi-immunoreaction of biotinylated streptavidin antibodies increased the selectivity and sensitivity for individual hormones in human blood samples...
June 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28640754/raised-tsh-is-associated-with-endothelial-dysfunction-in-metabolic-syndrome-a-case-control-study
#2
Ashok Kumar Ahirwar, Archana Singh, Anju Jain, Surajeet Kumar Patra, Binita Goswami, M K Bhatnagar, Jayashree Bhatacharjee
Introduction- Endothelial dysfunction has been considered as one of the important factor in pathogenesis of Metabolic Syndrome (Met S). Sub clinical hypothyroidism (SCH) has also been reported to be associated with Met S. The aim of our study is to evaluate the association of raised TSH with mediators of endothelial dysfunction in Met S with Sub clinical hypothyroidism as compared to healthy controls. Methods- Study population consisted of 100 subjects, out of which 50 were cases of Met S and 50 were healthy controls...
June 15, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28637498/incidence-of-thyroid-dysfunction-in-an-iranian-adult-population-the-predictor-role-of-thyroid-autoantibodies-results-from-a-prospective-population-based-cohort-study
#3
Ashraf Aminorroaya, Rokhsareh Meamar, Massoud Amini, Awat Feizi, Azamosadat Tabatabae, Elham Faghih Imani
BACKGROUND: The prevalence of thyroid dysfunction is high in Isfahan, an area of iodine sufficient in Iran. The aim of this study is to investigate the incidence of thyroid dysfunctions in adults of metropolitan Isfahan and to determine the role of thyroid autoantibodies. METHODS: In a population-based cohort study in 2006-2011, we measured TSH, T4, T3, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) in 618 out of 2254 people who were euthyroid in 2006...
June 21, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28633507/digenic-duox1-and-duox2-mutations-in-cases-with-congenital-hypothyroidism
#4
Zehra Aycan, Hakan Cangul, Marina Muzza, Veysel N Bas, Laura Fugazzola, V Krishna Chatterjee, Luca Persani, Nadia Schoenmakers
Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the TPO-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result in dyshormonogenetic Congenital Hypothyroidism (CH) which may be phenotypically heterogeneous, leading to the hypothesis that CH severity may be influenced by environmental factors (eg dietary iodine) and oligogenic modifiers (eg variants in the homologous NADPH-oxidase DUOX1). However, loss of function mutations in DUOX1 have not hitherto been described and its role in thyroid biology remains undefined...
June 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28627204/iodine-levels-are-associated-with-oxidative-stress-and-antioxidant-status-in-pregnant-women-with-hypertensive-disease
#5
Sergio Cuellar-Rufino, Mónica Navarro-Meza, Pablo García-Solís, Irene Xochihua-Rosas, Omar Arroyo-Helguera
BACKGROUND: The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported. AIM: To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD). METHOD: Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28626131/homozygous-duoxa2-mutation-p-tyr138-in-a-girl-with-congenital-hypothyroidism-and-her-apparently-unaffected-brother-case-report-and-review-of-the-literature
#6
Chiho Sugisawa, Shinji Higuchi, Masaki Takagi, Yukihiro Hasegawa, Matsuo Taniyama, Kiyomi Abe, Tomonobu Hasegawa, Satoshi Narumi
Mutations in DUOXA2, encoding dual oxidase maturation factor 2, is a rare genetic cause of congenital hypothyroidism. Only four biallelic DUOXA2 mutation carriers have been described to date. This study was conducted to report the clinical and genetic findings of a DUOXA2 mutation-carrying family, and to review the previously reported cases. The proband was a 4-year-old girl, who was diagnosed as having congenital hypothyroidism in the frame of newborn screening. She had a high serum TSH level (138 mU/L) and a low free T4 level (0...
June 16, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28621046/impact-of-borderline-subclinical-hypothyroidism-on-subsequent-pregnancy-outcome-in-women-with-unexplained-recurrent-pregnancy-loss
#7
Sayaka Uchida, Tetsuo Maruyama, Maki Kagami, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka
AIM: Because subclinical hypothyroidism (thyroid-stimulating hormone [TSH] > 4.5 IU/mL) is associated with adverse pregnancy outcome, including early pregnancy loss, TSH is recommended to be titrated to ≤2.5 mIU/L in levothyroxine-treated women before pregnancy. The purpose of this study was to determine whether borderline-subclinical hypothyroidism (borderline-SCH; 2.5 < TSH ≤ 4.5 IU/mL) affects the outcome of subsequent pregnancies in women with unexplained recurrent pregnancy loss (uRPL)...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28620500/lugol-s-solution-induced-painless-thyroiditis
#8
Ji Wei Yang, Jacques How
Lugol's solution is usually employed for a limited period for thyroidectomy preparation in patients with Graves' disease and for the control of severe thyrotoxicosis and thyroid storm. We describe a rare case of Lugol's solution-induced painless thyroiditis. In November 2014, a 59-year-old woman was prescribed Lugol's solution four drops per day for the alleviation of menopausal symptoms. She was referred to our clinic in June 2015 for fatigue, hair loss, and a 20-lb weight loss without thyroid pain or discomfort...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28618407/association-between-thyroid-function-and-body-mass-index-a-10-year-follow-up
#9
Hengameh Abdi, Elham Kazemian, Safoora Gharibzadeh, Atieh Amouzegar, Ladan Mehran, Maryam Tohidi, Zahra Rashvandi, Fereidoun Azizi
BACKGROUND/AIMS: We aimed to evaluate the association between change in thyroid function tests within the euthyroid range and body mass index (BMI) in persons with normal weight at baseline. METHODS: This study investigated 1,100 normal-weight euthyroid persons in a population-based cohort study, Tehran Thyroid Study. BMI was calculated and serum concentrations of thyrotropin (TSH) and free T4 (FT4) were assayed at baseline and after 10 years of follow-up. We evaluated the relationship between thyroid and obesity based on 2 definitions for outcome: (1) a binary outcome as BMI <25 or ≥25 kg/m2, and (2) a multinomial outcome as normal BMI, overweight, and obese...
June 16, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28614993/a-single-10mg-oral-dose-of-biotin-interferes-with-thyroid-function-tests
#10
Rosa Paula M Biscolla, Maria Izabel Chiamolera, Ina Kanashiro, Rui M B Maciel, Jose Gilberto Henriques Vieira
This letter reports a study with a single 10 mg oral dose of biotin in 19 health subjects. The acute use of biotin interferes with measurement of TSH, free T4 and T3, in a fashion similar to a hyperthyroid subject, and the changes are reversible 24 hours after the biotin ingestion.
June 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28611576/maternal-different-degrees-of-iodine-deficiency-during-pregnant-and-lactation-impair-the-development-of-cerebellar-pinceau-in-offspring
#11
Jing Dong, Heling Song, Yuan Wang, Min Li, Ye Yu, Yi Wang, Jie Chen
Aims: Iodine is critical for synthesis of thyroid hormones (TH). And iodine deficiency (ID) is one of the most significant reasons of intellectual disability and motor memory impairment, although the potential mechanisms are still under investigation. Presently, mild ID and marginal ID are largely ignored problems for women of child bearing age. Mild ID is a subtle form of TH deficiency, which shows low levels of free thyroxine (FT4) and relatively normal free triiodothyronine (FT3) or thyroid stimulation hormone (TSH)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28604338/intra-individual-variability-in-tsh-levels-of-healthy-women-during-the-first-half-of-pregnancy
#12
Mayte Murillo-Llorente, Carmen Fajardo-Montañana, Marcelino Pérez-Bermejo, Rafael Vila-Candel, José Gómez-Vela, Inés Velasco
OBJECTIVE: TSH is the parameter most widely accepted to assess thyroid function, especially in pregnant women. The aim of this current study was to analyze intra-individual changes in TSH during the first half of pregnancy in women with TSH levels higher than 2.5mIU/L in early pregnancy. METHODS: An observational, prospective study was conducted on 243 healthy pregnant women in the first trimester of pregnancy. Thyroid function was assessed by testing TSH and free T4 levels...
June 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28597456/-hypothyreosis-after-hemithyroidectomy-surprisingly-frequent-complication-in-aftercare
#13
Firat Elmas, Fabienne Lauber, Thomas Linder, Werner Müller
Background Hemithyroidectomy is a frequent treatment for thyroid nodules. Postoperative hypothyroidism is an often underestimated complication. We studied the incidence, time, symptoms and risk factors of postoperative hypothyroidism. Material and methods 127 Patients were analyzed in a retrospective chart review and with a structured assessment of the general practitioners and endocrinologists. Patients were classified according to the postoperative TSH as hypothyroid (>4.0 mU/L) or euthyroid (0.4-4.0 mU/L)...
June 8, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28593471/effects-of-combined-exposure-to-chronic-high-fat-diet-and-arsenic-on-thyroid-function-and-lipid-profile-in-male-mouse
#14
Akram Ahangarpour, Soheila Alboghobeish, Ali Akbar Oroojan, Leila Zeidooni, Azin Samimi, Golshan Afshari
The thyroid is one of the major endocrine glands that contribute to body and fat metabolism. The present study evaluated the effects of combined exposure to chronic high-fat diet (HFD) and arsenic on thyroid function and lipid profile. In this experimental study, 72 male Naval Medical Research Institute mice were divided into six groups and fed HFD or low-fat diet (LFD) while being exposed to 25 or 50 ppm of arsenic in drinking water for 20 weeks. After 24 h of the last experimental day, blood samples were collected for hormonal and biochemical measurements...
June 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28589090/neither-baseline-nor-changes-in-serum-triiodothyronine-during-levothyroxine-liothyronine-combination-therapy-predict-a-positive-response-to-this-treatment-modality-in-hypothyroid-patients-with-persistent-symptoms
#15
Bjarke Borregaard Medici, Jeppe Lerche la Cour, Luba Freja Michaelsson, Jens Oscar Faber, Birte Nygaard
BACKGROUND: Despite biochemical euthyroidism, some levothyroxine (L-T4)-treated hypothyroid patients report persisting symptoms and some of these patients are tentatively treated with a combination of L-T4 and liothyronine (L-T3). Combination therapy and the appropriate choice of blood tests to monitor treatment are highly debated among specialists and patients. AIM: To evaluate whether measuring serum triiodothyronine (S-T3) at baseline or during combination therapy can be used as an indicator of a positive effect from L-T4/L-T3 combination therapy...
April 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28585021/the-relationship-between-hyperthyrotropinemia-and-metabolic-and-cardiovascular-risk-factors-in-a-large-group-of-overweight-and-obese-children-and-adolescents
#16
G Radetti, G Grugni, F Lupi, N Marazzi, S Longhi, A Fanolla, A Sartorio
PURPOSE: Mild TSH elevations are frequently observed in obese patients, in the absence of any detectable thyroid disease. Our objective is to evaluate the relationship between the raised TSH levels and the biochemical and clinical consequences of obesity. METHODS: This is a retrospective cross-sectional study of a large population of obese children and adolescents. We evaluated 833 subjects (340 m, 493 f), aged 14.4 ± 2.5 (range 5.2-18.5) years, height SDS 0...
June 5, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28580441/impact-of-subclinical-hypothyroidism-on-cardiometabolic-biomarkers-in-women
#17
Paulo H N Harada, Julie E Buring, Nancy R Cook, Michael E Cobble, Krishnaji R Kulkarni, Samia Mora
CONTEXT: Whether subclinical hypothyroidism (SCH) is associated with cardiometabolic abnormalities is uncertain. OBJECTIVE: To examine diverse cardiometabolic biomarkers across euthyroid, SCH, and overt hypothyroidism (HT) in women free of cardiovascular disease (CVD). DESIGN: Cross-sectional adjusted associations for lipids, lipoprotein subclasses, lipoprotein insulin resistance score, inflammatory, coagulation, and glycemic biomarkers by ANCOVA for thyroid categories or TSH quintiles on a Women's Health Study subcohort...
February 1, 2017: J Endocr Soc
https://www.readbyqxmd.com/read/28575418/sorafenib-induced-changes-in-thyroid-hormone-levels-in-patients-treated-for-hepatocellular-carcinoma
#18
Carolien M Beukhof, Leni van Doorn, Theo J Visser, Sander Bins, W Edward Visser, Ramona van Heerebeek, Folkert J van Kemenade, Yolanda B de Rijke, Wouter W de Herder, Layal Chaker, Ron H Mathijssen, Robin P Peeters
Context: The pathogenesis of tyrosine kinase inhibitor-induced thyroid hormone (TH) alterations and the effects on TH metabolism and transport are still a matter of debate. Objective: To study the effects of sorafenib on TH levels in patients with hepatocellular carcinoma (HCC) and evaluate possible mechanisms underlying these changes. Design: Prospective cohort study between 2009 and 2016. Setting: Tertiary referral center...
May 26, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28572820/tsh-variability-of-patients-affected-by-differentiated-thyroid-cancer-treated-with-levothyroxine-liquid-solution-or-tablet-form
#19
Carlo Cappelli, Ilenia Pirola, Elena Gandossi, Claudio Casella, Davide Lombardi, Barbara Agosti, Fiorella Marini, Andrea Delbarba, Maurizio Castellano
BACKGROUND: Recent guidelines from the American Thyroid Association (ATA) indicate that, in many patients affected by differentiated thyroid cancer (DTC), the serum TSH should be maintained between 0.1 and 0.5 mU/L. The purpose of this study was to evaluate the TSH variability of patients affected by DTC treated with liquid L-T4 formulation or in tablet form. PATIENTS AND METHODS: Patients were eligible if (a) they were submitted to a total thyroidectomy and (131)I remnant ablation for DTC in our institution and (b) they were classified low-risk patients according to ATA guidelines 2009...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28571126/study-of-glycated-haemoglobin-hba1c-in-non-diabetic-subjects-with-subclinical-hypothyroidism
#20
Mayur Goradhanbhai Makadia, Vishwal Indravadan Patel, Kinjal Prahaladbhai Patel, Aashna Darshanbhai Shah, Kaushik Salubhai Chaudhari, Hitesh Natvarbhai Shah, Haridas Neelakandan Nilayangode
INTRODUCTION: India has the higher prevalence of prediabetes, diabetes and hypothyroidism. Subclinical Hypothyroidism (SH) is more prevalent in the females than in the males. Studies have shown the elevated HbA1c in the non-diabetic hypothyroid patients. SH is defined by normal serum triiodothyronine (T3), thyroxine (T4) levels and serum Thyroid Stimulating Hormone (TSH) level falling between 4.2 to 10 mU/L. AIM: To study the HbA1c level in the non-diabetic SH patients and to compare the HbA1c level with the controls...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
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