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https://www.readbyqxmd.com/read/29154201/neuroendocrine-disorder-in-chronic-fatigue-syndrome
#1
Slavica Tomic, Snezana Brkic, Dajana Lendak, Daniela Maric, Milica Medic Stojanoska, Aleksandra Novakov Mikic
Background/aim: Neuroendocrine disorders are considered a possible pathogenetic mechanism in chronic fatigue syndrome (CFS). The aim of our study was to determine the function of the hypothalamic-pituitary-adrenal axis (HPA) and thyroid function in women of reproductive age suffering from CFS. Materials and methods: The study included 40 women suffering from CFS and 40 healthy women (15-45 years old). Serum levels of cortisol (0800 and 1800 hours), ACTH, total T4, total T3, and TSH were measured in all subjects...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#2
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142854/skin-metastasis-on-the-neck-an-unusual-presentation-of-recurrence-of-papillary-thyroid-carcinoma
#3
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Skin metastasis of papillary thyroid carcinoma (PTC) is rare. Here, two cases of skin metastases of PTC are presented. Both of the patients were females, one is 83 and the other is 65 years old. The patients were admitted to the hospital with a movable skin lesion on anterior neck region. Free T3 and T4 levels were in normal levels and TSH levels were low in both patients. The 83-year-old patient underwent total thyroidectomy due to papillary thyroid cancer and received (131)I ablation therapy and then thyroid suppression therapy...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29142853/silk-suture-reaction-in-thyroid-surgery
#4
Selen Soylu, Akif Enes Arikan, Serkan Teksoz, Murat Ozcan, Yusuf Bukey
Silk suture reaction (i.e., a benign granulomatous inflammatory foreign body reaction) is a rare complication of thyroid surgery. Here, two cases of post-thyroidectomy suture reaction are presented. Both of the patients were female, one is 48 and the other is 34 years old. The patients were presented with neck swelling and leakage of serous fluid from the Kocher's incision. Both patients had normal free T4, free T3, and TSH values. The 48-year-old female patient had a right subtotal and left near-total thyroidectomy 6 years ago and the other had bilateral total thyroidectomy 6 years ago...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29139221/evaluation-of-hypothalamus-pituitary-thyroid-axis-function-by-chronic-perchlorate-exposure-in-male-rats
#5
Caroline Serrano-Nascimento, Jamile Calil-Silveira, Rafael Dalbosco, Telma Tenorio Zorn, Maria Tereza Nunes
Perchlorate is a widespread endocrine disruptor that was previously correlated with increased serum TSH levels and decreased thyroid hormones production both in animals and humans. Even so, the regulation of gene/protein expression in the hypothalamus, pituitary and thyroid by chronic perchlorate exposure was not completely elucidated. Therefore, this study aimed to investigate the underlying mechanisms involved in the disruption of hypothalamus-pituitary-thyroid axis by chronic perchlorate exposure. Male Wistar rats were treated or not with NaClO4 in the drinking water (35 mg/Kg/day) for 60 days...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29132242/relationship-between-thyroid-hormone-levels-and-transient-tachypnea-of-the-newborn-in-late-preterm-early-term-and-term-infants
#6
Sinan Kayıran, Seçil Erçin, Petek Kayıran, Tugba Gursoy, Berkan Gurakan
PURPOSE: We aimed to investigate the association between thyroid hormone levels and transient tachypnea of the newborn (TTN) among late-preterm, early-term, and term infants admitted to neonatal intensive care unit (NICU). MATERIAL AND METHODS: In the current retrospective study, neonates admitted to the NICU due to TTN were assigned to the TTN group (n = 404). Healthy neonates who were followed up in the well-baby nursery comprised the control group (n = 7335)...
November 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29121201/high-prevalence-of-radiological-vertebral-fractures-in-women-on-tsh-suppressive-therapy-for-thyroid-carcinoma
#7
Gherardo Mazziotti, Anna Maria Formenti, Stefano Frara, Roberto Olivetti, Giuseppe Banfi, Maurizio Memo, Roberto Maroldi, Raffaele Giubbini, Andrea Giustina
Context: Bone loss and non-vertebral fractures have been reported in patients with differentiated thyroid carcinoma (DTC) undergoing TSH-suppressive therapy. Radiological vertebral fractures (VFs) are an early and clinically crucial marker of bone fragility but they have never been investigated so far in this specific clinical setting. Objective and design: In this cross-sectional study we evaluated the prevalence and determinants of radiological VFs in women under L-T4 therapy for DTC...
November 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29120584/autoimmune-thyroiditis-a-case-control-study-on-a-sample-of-egyptian-type-i-diabetic-patients
#8
Hoda G Bakr, Ihab M Salem, Takwa E Meawed, Reham H Anis, Mohamed H El-Hefnawy
Type 1 diabetic patients are vulnerable for autoimmune thyroid disease. The incidence of type I Diabetes in Egypt is 8/100000. Undiagnosed thyroid dysfunction impairs metabolic status and increase cardiovascular risks in diabetic patients. Objectives of the study were to underscore autoimmune thyroiditis and thyroid dysfunction on a sample of Egyptian type I diabetes mellitus. One hundred type 1 diabetic subjects without previously known thyroid diseases and 50 controls were included. Physical examination, HbA1c, thyroid profile (TSH, free T3 and free T4), thyroid ultrasound anti-peroxidase and anti-thyroglobulin antibodies were assessed...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29113346/study-on-the-status-of-thyroid-function-and-thyroid-nodules-in-chinese-breast-cancer-patients
#9
Yanling Shi, Xin Li, Liang Ran, Bilal Arshad, Hao Li, Zhou Xu, Chunxia Zhao, Yutuan Wu, He Wu, Haoran Chen, Hong-Yuan Li, Kai-Nan Wu, Ling-Quan Kong
We performed a study to investigate the status of thyroid nodules and thyroid functions in Chinese breast cancer women. The clinical data of female patients with breast cancer or benign breast diseases and normal populace were evaluated. The thyroxine(T4) level in initially diagnosed breast cancer patients were significantly higher than those in benign breast diseases patients (7.68±1.51 vs 7.29±1.52ug/dl, p<0.001), while the TSH levels were slightly lower than in benign breast diseases patients(3.23±4...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105255/analysis-of-current-thyroid-function-test-ordering-practices
#10
Joseph K Kluesner, Darrick J Beckman, Joshua M Tate, Alexis A Beauvais, Maria I Kravchenko, Jana L Wardian, Sky D Graybill, Jeffrey A Colburn, Irene Folaron, Mark W True
RATIONALE: Current guidelines recommend thyroid stimulating hormone (TSH) alone as the best test to detect and monitor thyroid dysfunction, yet free thyroxine (FT4) and free triiodothyronine (FT3) are commonly ordered when not clinically indicated. Excessive testing can lead to added economic burden in an era of rising healthcare costs, while rarely contributing to the evaluation or management of thyroid disease. OBJECTIVE: To evaluate our institution's practice in ordering thyroid function tests (TFTs) and to identify strategies to reduce inappropriate FT4 and FT3 testing...
November 3, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29102897/the-hypothalamic-pituitary-thyroid-axis-and-personality-in-a-sample-of-healthy-subjects
#11
Aleksei Piskunov, Adela Fusté, Nadezhda Teryaeva, Aleksei Moshkin, José Ruiz
Thyroid hormones influence various brain pathologies, including psychiatric disorders. However, the relationship between these hormones and the psychological state in the normal, non-clinical population is poorly understood. We aimed to test whether serum levels of thyroid hormones are associated with personality in the healthy population. Thyrotropin (TSH), free T3 (FT4), total and free T4 (TT4 and FT4) concentrations were measured in the blood of 104 healthy participants (44% men) aged 18-59 (M=35±9). Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI)...
October 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29099903/-repeatability-and-variability-of-total-t4-measurements-at-three-german-veterinary-laboratories
#12
Ralf Mueller, Teresa Böhm, Christoph Klinger, Janine Classen, Laura Udraite, Monika Linek, Ralf S Mueller
OBJECTIVE: To evaluate the reproducibility of serum testing for total thyroxine (T4) in three German laboratories. MATERIALS AND METHODS: Serum was taken from 53 dogs with suspected hypothyroidism and divided into five aliquots. Three aliquots of each sample were marked with different names and sent to one laboratory (two aliquots simultaneously and one aliquot 1-3 days later). The remaining aliquots were sent to two other laboratories. Laboratory 1 used an enzyme immunoassay for T4 measurements, whereas laboratories 2 and 3 used a chemiluminescence immunoassay...
November 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29089885/repetitive-transcranial-magnetic-stimulation-rtms-modulates-lipid-metabolism-in-aging-adults
#13
Weicong Ren, Jiang Ma, Juan Li, Zhijie Zhang, Mingwei Wang
Hyperlipidemia, one of the cardiovascular (CV) risk factors, is associated with an increase in the risk for dementia. Repetitive transcranial magnetic stimulation (rTMS) was applied over the right dorsolateral prefrontal cortex (DLPFC) to modulate serum lipid levels in older adults. Participants received 10 sessions of rTMS or sham stimulation intervention within 2 weeks. The serum lipid and thyroid hormone-related endocrine levels were assessed before and after the treatment. We found that rTMS significantly decreased serum lipid levels, including the total cholesterol (CHO) and triglyceride (TG); meanwhile, it also increased the thyroid-stimulating hormone (TSH) as well as thyroxine (T4) levels...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29074613/the-incidence-of-congenital-hypothyroidism-ch-in-guangxi-china-and-the-predictors-of-permanent-and-transient-ch
#14
Chunyun Fu, Shiyu Luo, Yingfeng Li, Qifei Li, Shangyang She, Xuehua Hu, Mengting Li, Yue Zhang, Jiasun Su, Xuyun Hu, Yun Chen, Jin Wang, Bobo Xie, Shujie Zhang, Jingsi Luo, Xin Fan, Shaoke Chen, Yiping Shen
OBJECTIVE: To investigate the incidence of CH in Guangxi, China, and to analyze the predictors that might allow for an early differentiation between permanent (P) and transient (T) CH. DESIGN AND METHODS: Blood samples were collected on filter paper between 3-7 days after birth, TSH level was measured by time-resolved fluorescence assay. Individuals with increased TSH levels detected by newborn screening were recalled for further evaluation by electrochemiluminescence assay...
October 26, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29071237/the-effect-of-daily-versus-weekly-levothyroxine-replacement-on-thyroid-function-test-in-hypothyroid-patients-at-a-tertiary-care-centre-in-haryana
#15
Rajesh Rajput, Vaibhav Pathak
OBJECTIVE: We compare the effect of daily versus weekly levothyroxine (LT4) replacement on thyroid function test (TFT) in hypothyroid patients at a tertiary care centre in Haryana. MATERIALS AND METHODS: This was a randomised crossover study in which 100 hypothyroid patients on a stable LT4 dose were divided into 2 groups of 50 each. In group I, patients were given daily therapy for 6 weeks and then shifted to weekly therapy for the next 6 weeks. In group II, patients were given LT4 once a week for 6 weeks and then switched to daily therapy for the next 6 weeks...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29065864/do-some-anxiety-disorders-belong-to-the-prodrome-of-bipolar-disorder-a-clinical-study-combining-retrospective-and-prospective-methods-to-analyse-the-relationship-between-anxiety-disorder-and-bipolar-disorder-from-the-perspective-of-biorhythms
#16
Na Du, Ya-Ling Zhou, Xu Zhang, Jing Guo, Xue-Li Sun
BACKGROUND: In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar disorder (BD) many years later, and some cases of AD may be cured by the use of mood stabilizers. However, the relationship between AD and BD should be explored further. METHOD: To track how many cases of AD turned to BD and to discover the differences between them, we recruited 48 patients diagnosed with BD, who were assigned to the BD group for the retrospective analysis, and we also recruited 186 patients diagnosed with AD at enrolment; this latter group was asked to complete follow-up surveys conducted 3 months, 6 months, 12 months and 18 months after the primary stage of the study...
October 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29063198/dental-fluorosis-nutritional-status-kidney-damage-and-thyroid-function-along-with-bone-metabolic-indicators-in-school-going-children-living-in-fluoride-affected-hilly-areas-of-doda-district-jammu-and-kashmir-india
#17
Arjun L Khandare, Shankar Rao Gourineni, Vakdevi Validandi
A case-control study was undertaken among the school children aged 8-15 years to know the presence and severity of dental fluorosis, nutrition and kidney status, and thyroid function along with bone metabolic indicators in Doda district situated at high altitude where drinking water was contaminated and heat stress. This study included 824 participants with an age of 8-15 years. The results of the study reviled that dental fluorosis was significantly higher in affected than control area children. Urinary fluoride was significantly higher (p < 0...
October 23, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29062583/the-end-diastolic-velocity-of-thyroid-arteries-is-strongly-correlated-with-the-peak-systolic-velocity-and-gland-volume-in-patients-with-autoimmune-thyroiditis
#18
Danilo Bianchini Höfling, Suemi Marui, Carlos Alberto Buchpiguel, Giovanni Guido Cerri, Maria Cristina Chammas
BACKGROUND: The end-diastolic velocity (EDV) of thyroid arteries reflects peripheral blood flow resistance. OBJECTIVE: The aim was to evaluate EDV correlations with other Doppler sonography parameters and with clinical and biochemical variables in a sample of patients with hypothyroidism caused by chronic autoimmune thyroiditis (CAT). METHODS: A sample of 48 CAT hypothyroid patients receiving treatment with stable doses of levothyroxine was selected...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29045188/rapid-evolution-of-thyroid-dysfunction-in-patients-treated-with-nivolumab
#19
Grenye O'Malley, Hanna J Lee, Samir Parekh, Matthew D Galsky, Cardinale B Smith, Philip Friedlander, Robert T Yanagisawa, Emily J Gallagher
OBJECTIVE: To describe the evolution of thyroid dysfunction in a series of patients with cancer treated with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) monoclonal antibody, nivolumab. METHODS: Cases of thyroid dysfunction after initiation of checkpoint inhibitor treatment were identified from the Division of Endocrinology clinical practice at Mount Sinai Hospital, New York from April 2016 to February 2017. Charts were reviewed to identify patients treated with nivolumab with new onset of thyroid dysfunction...
October 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29040069/effects-of-1-year-growth-hormone-replacement-therapy-on-thyroid-volume-and-function-of-the-children-and-adolescents-with-idiopathic-growth-hormone-deficiency
#20
Meliksah Keskin, Elvan Bayramoglu, Zehra Aycan
BACKGROUND: There are different opinions about the effects of growth hormone replacement therapy (GHRT) on thyroid function and volume. This study aimed to assess the effects of GHRT on thyroid volume and function in the children and adolescents with growth hormone (GH) deficiency. METHODS: A total of 29 patients diagnosed with GH deficiency were enrolled in the study. The control group consisted of 29 cases matched for age, gender and pubertal period with the patients...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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