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FSH AND Iodine

F Acıbucu, D O Acıbucu, Ö B Akkar, H S Dokmetas
Introduction: Radioactive iodine (RAI) ablation treatment is used for patients diagnosed with well-differentiated thyroid cancer in order to reduce the risk of recurrence. RAI ablation treatment can adversely affect gonads in males and females. In this study, we aimed to determine ovary damage and infertility risk due to RAI, using serum anti-Müllerian hormone (AMH) level, in females who received RAI ablation treatment. Materials and Methods: 45 female patients who have not gone through the menopause and had received RAI ablation treatment for well-differentiated thyroid cancer in premenopausal period, and 40 healthy females as control groups were included in this study...
October 6, 2016: Experimental and Clinical Endocrinology & Diabetes
Domenico Canale, Claudia Ceccarelli, Carolina Caglieresi, Agnese Moscatelli, Silvia Gavioli, Pierina Santini, Rossella Elisei, Paolo Vitti
OBJECTIVE: To evaluate the effects of radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) on testis function. DESIGN: A prospective longitudinal single-centre study was performed. A comprehensive andrological evaluation including hormonal assessment, semen analysis and scrotal ultrasound was undertaken in male patients undergoing RAI treatment for DTC. METHODS: Hormonal assessment of FSH, LH, testosterone (T), sperm concentration and motility and testis volume were determined in 20 patients in basal conditions, 6 and 12 months after RAI...
February 2015: Clinical Endocrinology
George R Bousfield, Vladimir Y Butnev, Viktor Y Butnev, Yasuaki Hiromasa, David J Harvey, Jeffrey V May
Hypo-glycosylated hFSH(21/18) (possesses FSHβ(21) and FSHβ(18)bands) was isolated from hLH preparations by immunoaffinity chromatography followed by gel filtration. Fully-glycosylated hFSH(24) was prepared by combining the fully-glycosylated FSHβ(24) variant with hCGα and isolating the heterodimer. The hFSH(21/18) glycoform preparation was significantly smaller than the hFSH(24) preparation and possessed 60% oligomannose glycans, which is unusual for hFSH. Hypo-glycosylated hFSH(21/18) was 9- to 26-fold more active than fully-glycosylated hFSH(24) in FSH radioligand assays...
February 15, 2014: Molecular and Cellular Endocrinology
S C Clement, K C J M Kraal, B L F van Eck-Smit, C van den Bos, L C M Kremer, G A M Tytgat, H M van Santen
BACKGROUND: Primary ovarian insufficiency (POI) is a noted late effect in childhood cancer survivors treated with alkylating agents or after radiation to a field that includes the ovaries. Gonadal failure in children with neuroblastoma (NBL) who were exposed to 131I- metaiodobenzylguanidine (MIBG) has only been reported in those who were also treated with chemotherapy. In these cases, the cause of gonadal failure was assumed to be the cytotoxic therapy. Here, we present the first two cases of POI after 131I-MIBG treatment only for NBL, indicating that 131I-MIBG treatment may have a causative role...
January 2014: Journal of Clinical Endocrinology and Metabolism
James A Dias, Béatrice Bonnet, Barbara A Weaver, Julie Watts, Kerri Kluetzman, Richard M Thomas, Sonia Poli, Vincent Mutel, Brice Campo
High quality gamete production in males and females requires the pituitary gonadotropin follicle stimulating hormone (FSH). In this report a novel chemical class of small molecule inhibitors of FSH receptor (FSHR) is described. ADX61623, a negative allosteric modulator (NAM), increased the affinity of interaction between (125)I-hFSH and human FSHR (hFSHR) five fold. This form of FSHR occupied simultaneously by FSH and ADX61623 was inactive for cAMP and progesterone production in primary cultures of rat granulosa cells...
February 20, 2011: Molecular and Cellular Endocrinology
Pedro Weslley Rosário, Michelle Aparecida Ribeiro Borges, Saulo Purisch
UNLABELLED: Preparation with recombinant human thyroid-stimulating hormone (rhTSH) for thyroid remnant ablation results in lower extrathyroidal radiation than does hypothyroidism. The objective of this prospective study was to compare the damage caused by 131I (3.7 GBq) when these 2 preparations are used. METHODS: Ninety-four consecutive patients who underwent total thyroidectomy and remnant ablation with 3.7 GBq of 131I were studied. Thirty patients (group A) received rhTSH, and 64 (group B) were prepared by levothyroxine withdrawal...
November 2008: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Antoine Hannoun, Johnny Awwad, Tony Zreik, Ghina Ghaziri, Antoine Abu-Musa
OBJECTIVE: The objective of this study is to assess the effect of two methods of vaginal scrubbing before egg retrieval on the outcome of in vitro fertilization-embryo transfer (IVF-ET) cycles. METHOD: 721 consecutive cycles of IVF-ET, at the American University Hospital of Beirut, were randomized prospectively into one of two groups. In the study group the betadine used to scrub the vagina, prior to egg retrieval, was not washed out, whereas in the control group this betadine was cleansed by saline irrigation...
2008: Gynecologic and Obstetric Investigation
Anna M Sawka, Jane Lea, Bandar Alshehri, Sharon Straus, Richard W Tsang, James D Brierley, Lehana Thabane, Lorne Rotstein, Amiram Gafni, Shereen Ezzat, David P Goldstein
BACKGROUND: For patients with well-differentiated thyroid carcinoma (WDTC), the gonadal effects of radioactive iodine (RAI) therapy is an important consideration. OBJECTIVE AND METHODS: We systematically reviewed the controlled studies examining the gonadal effects of RAI therapy in male WDTC survivors. We searched in nine electronic databases. All abstracts and papers were independently reviewed by two reviewers. RESULTS: After reviewing 334 abstracts and 59 full-text papers, seven papers were included...
April 2008: Clinical Endocrinology
P Agretti, G De Marco, A Pinchera, P Vitti, J Bernal, M Tonacchera
Ras homolog enriched in striatum (Rhes) is a member of the Ras family of small GTPases detected in the thyroid. Rhes inhibits signal transduction from Galphas protein. In this study we investigated whether Rhes can interfere with stimulation of cAMP/protein kinase A (PKA) pathway of TSH, FSH and LH receptors (TSHr, FSHr, LHr) and of activated TSHr mutants. Receptors were transiently transfected in COS-7 cells with or without Rhes; cAMP was evaluated in basal conditions and after hormone stimulation. Constitutive and bovine TSH (bTSH)-stimulated activity of wild type (wt) and mutated TSHr was inhibited after Rhes co-transfection...
April 2007: Journal of Endocrinological Investigation
Ginny L Ryan, Xiuyan Feng, Catarina Brasil d'Alva, Meilin Zhang, Bradley J Van Voorhis, Emilia Modolo Pinto, Ana Elisa F Kubias, Sonir R Antonini, Ana Claudia Latronico, Deborah L Segaloff
CONTEXT: Rare activating mutations of the human (h)FSHR have been reported in some women with spontaneous ovarian hyperstimulation in pregnancy, where follicular growth is inappropriately stimulated by elevated concentrations of human chorionic gonadotropin acting through the hFSHR. It is not known whether ovarian hyperstimulation in peripubertal girls with untreated primary hypothyroidism is caused by hFSHR mutations and/or influenced by hFSHR allelic variants, rendering the hFSHR more sensitive to circulating TSH...
June 2007: Journal of Clinical Endocrinology and Metabolism
Takashi Minegishi, Kazuto Nakamura, Soichi Yamashita, Yuki Omori
A splice variant of human lutropin/choriogonadotropin-receptor [hLHR (exon 9)] that lacks exon 9 was previously cloned in the corpus luteum of a woman with a regular menstrual-cycle. Supported by detergent soluble binding assay and receptor biotinylation experiment, the receptor binding assay shows hLHR (exon 9) is neither expressed at the cell surface nor have the capability of binding to hCG. Interactions between hLHR (exon 9) with the immature bands of gonadotropin receptors not with the mature bands were seen...
January 2, 2007: Molecular and Cellular Endocrinology
Win Lin, Michael P Bernard, Donghui Cao, Rebecca V Myers, John E Kerrigan, William R Moyle
Human choriogonadotropin (hCG) and follitropin (hFSH) have been shown to contact different regions of the extracellular domains of G-protein coupled lutropin (LHR) and follitropin (FSHR) receptors. We report here that hCG and hFSH analogs interact with different regions of an FSHR/LHR chimera having only two unique LHR residues and that binds both hormones with high affinity. hCG and hFSH analogs dock with this receptor chimera in a manner similar to that in which they bind LHR and FSHR, respectively. This shows that although the FSHR does not normally bind hCG, it contains a cryptic lutropin binding site that has the potential to recognize hCG in a manner similar to the LHR...
January 2, 2007: Molecular and Cellular Endocrinology
Claudia Ceccarelli, Domenico Canale, Paolo Battisti, Carolina Caglieresi, Cecilia Moschini, Emilio Fiore, Lucia Grasso, Aldo Pinchera, Paolo Vitti
OBJECTIVE: Radioiodine-131 is commonly used for treatment of hyperthyroidism but there are few available data on the effects of this treatment on male gonadal function. The untoward effects of (131)I have been mainly studied in male patients treated with high doses for thyroid cancer. In the present work we studied the absorbed radiation dose to the testes and testicular function in hyperthyroid men after (131)I treatment. PATIENTS AND MEASUREMENTS: Nineteen male hyperthyroid patients were enrolled in the study before (131)I therapy...
October 2006: Clinical Endocrinology
Pedro W S Rosário, Alvaro L Barroso, Leonardo L Rezende, Eduardo L Padrão, Michelle A R Borges, Valéria C Guimarães, Saulo Purisch
Our aim was to assess testicular function in patients treated with high-dose radioiodine. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels were determined in 52 men with thyroid carcinoma before and 6, 12, and 18 months after radioiodine therapy (3.7-5.5 GBq (131)I; mean, 4.25 GBq (131)I) (group 1) and were also determined before and 18 months after the last radioiodine therapy in 22 patients who received high cumulative activities (13-27.7 GBq; mean, 20.3 GBq (131)I) (group 2)...
July 2006: Thyroid: Official Journal of the American Thyroid Association
Armaghan Fard Esfahani, Mohammad Eftekhari, Navid Zenooz, Mohsen Saghari
The aim of this study was to evaluate the effect of treatment with radioactive iodine ((131)I) on gonadal function in males and females with follicular or papillary thyroid carcinoma. Consenting patients at reproductive age were grouped according to the cumulative dose of (131)I received and followed-up for at least 12 months. Overall, 246 patients (159 females, 87 males) were studied. In all males, serum levels of follicle-stimulating hormone (FSH), luteinising hormone (LH), and testosterone were measured before radioiodine treatment and 2, 6 and 12 months afterwards; fifty-three of all patients underwent semen analysis also...
January 2004: Hellenic Journal of Nuclear Medicine
L Starka, M Duskova, I Cermakova, J Vrbiková, M Hill
BACKGROUND: Polycystic ovary syndrome (PCOS), the most frequent endocrinopathy in women with estimated prevalence of 5-10 %, is characterised by a hormonal and metabolic imbalance of polygene autosomal trait. The complexity of symptoms and genetic base started up the hypothesis on the existence of male equivalent of PCOS. Precocious loss of hair before 30 years of age was suggested as one of the male symptoms of this syndrome. OBJECTIVES: The aim was to confirm the association of lower levels of follicle stimulating hormone (FSH) and sexual hormone binding globulin (SHBG) or higher free androgen index (FAI) in premature balding men with a reduced insulin sensitivity...
December 2005: Endocrine Regulations
Pedro Weslley S Rosário, Ludmilla David Cardoso, Alvaro Luís Barroso, Eduardo L Padrão, Leonardo Lamego Rezende, Saulo Purisch
We studied 20 patients with differentiated thyroid carcinoma undergoing radioiodine therapy (> or = 100 mCi dose) before the age of 21: 10 patients without distant metastases received a mean dose of 145 mCi and 10 with lung involvement received 270 mCi. One or more years after ablative therapy, xerostomia was present in two patients but was not accompanied by more severe complications such as oral ulcers or fissures, and 99mTcO4- scintigraphy confirmed salivary dysfunction. One patient showed keratoconjunctivitis sicca...
April 2005: Arquivos Brasileiros de Endocrinologia e Metabologia
P W Souza Rosário, T Alvarenga Fagundes, A S Villas-Boas Fagundes, A L Barroso, L Lamego Rezende, E Lanza Padrão, V C Guimarães, A C Horta, M Franco, S Purisch
OBJECTIVE: To assess ovarian function in young women treated with radioiodine. METHODS: The study was conducted on 50 women with thyroid carcinoma aged less than 40 years (mean, 29.8 years), with regular menstrual cycles and normal FSH levels prior to radioiodine therapy. FSH determination was repeated 6 and 12 months after radioiodine therapy (mean, 4.24 GBq iodine-131) and menstrual cycles were monitored during this period. RESULTS: Twenty percent of the patients reported amenorrhea during the first year...
June 2005: Experimental and Clinical Endocrinology & Diabetes
Francesc Xavier Donadeu, Mario Ascoli
Signaling pathways mediating the divergent effects of FSH and LH on aromatase in immature rat granulosa cells were studied by infecting cells with increasing amounts of adenoviral vectors for the human LH receptor (hLHR) or FSH receptor (hFSHR). Increasing amounts of Ad-hLHR, used at a multiplicity of infection (MOI) of 20 or 200 viable viral particles/cell, increased human chorionic gonadotropin (hCG) binding and hCG-induced cAMP and Akt phosphorylation, but inositol phosphates only increased in response to hCG in cells infected with 200 MOI Ad-hLHR...
September 2005: Endocrinology
A Wayne Meikle
Thyroid hormone deficiency affects all tissues of the body, including multiple endocrine changes that alter growth hormone, corticotrophin, glucocorticoids, and gonadal function. Primary hypothyroidism is associated with hypogonadotropic hypogonadism, which is reversible with thyroid hormone replacement therapy. In male children follicle-stimulating hormone (FSH) is elevated and associated with testicular enlargement without virilization. Men with primary hypothyroidism have subnormal responses of luteinizing hormone (LH) to gonadotropin-releasing hormone (GnRH) administration and normal response to human chorionic gonadotropin (hCG)...
2004: Thyroid: Official Journal of the American Thyroid Association
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