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Nolwenn Briand, Cécilia Prado, Guillaume Mabilleau, Françoise Lasnier, Xavier Le Lièpvre, Jeffrey D Covington, Eric Ravussin, Soazig Le Lay, Isabelle Dugail
Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic diabetes in humans, which cannot be reversed by endothelial rescue of caveolin expression in mice, indicating major importance of adipocyte caveolae. However, how caveolae participate in fat cell functions is poorly understood. We investigated dynamic conditions of lipid store fluctuations and demonstrate reciprocal regulation of caveolae density and fat cell lipid droplet storage...
December 2014: Diabetes
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