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Sex differences, antidepressant

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https://www.readbyqxmd.com/read/28730691/effect-of-abrupt-discontinuation-of-antidepressants-in-critically-ill-hospitalized-adults
#1
Taryn B Bainum, David S Fike, Diana Mechelay, Krystal K Haase
OBJECTIVES: To determine whether discontinuation of chronic antidepressant therapy is associated with a higher risk of antidepressant discontinuation syndrome (ADS) symptoms in patients admitted to the intensive care unit (ICU) when compared with those who were continued on therapy and to identify factors associated with increased risk of ADS in this population. DESIGN: Single-center retrospective observational cohort study. SETTING: ICUs in a tertiary care hospital...
July 21, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28729116/convergence-of-glycogen-synthase-kinase-3%C3%AE-and-gr-signaling-in-response-to-fluoxetine-treatment-in-chronically-stressed-female-and-male-rats
#2
Milos Mitic, Zeljka Brkic, Iva Lukic, Miroslav Adzic
Accumulating evidence strongly suggest that impaired glucocorticoid receptor (GR) signaling is involved in stress-related mood disorders, and nominate GR as a potential target for antidepressants (ADs). It is known that different classes of ADs affects the GR action via modifying its phosphorylation, while the mechanism through which ADs alter GR phosphorylation targeted by GSK3β, a kinase modulated via serotonin neurotransmission, are unclear. On this basis, we investigated whether GSK3β-GR signaling could be a convergence point of fluoxetine action on brain function and behavior, by examining its effect on GSK3β targeted-GR phosphorylation on threonine 171 (pGR171), and expression of GR-regulated genes in the hippocampus of female and male rats exposed to chronic isolation stress...
July 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28718661/anxiety-and-self-care-behaviour-in-patients-with-chronic-systolic-heart-failure-a-multivariate-model
#3
Thomas Müller-Tasch, Bernd Löwe, Nicole Lossnitzer, Lutz Frankenstein, Tobias Täger, Markus Haass, Hugo Katus, Jobst-Hendrik Schultz, Wolfgang Herzog
BACKGROUND: While comprehensive evidence exists regarding negative effects of depression on self-care behaviours in patients with chronic heart failure (CHF), the relation between anxiety and self-care behaviours in patients with CHF is not clear. The aim of this study was to analyse the interactions between anxiety, depression and self-care behaviours in patients with CHF. METHODS: The self-care behaviour of CHF outpatients was measured using the European Heart Failure Self-care Behaviour Scale (EHFScBS)...
July 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28684241/anxious-depression-and-neurocognition-among-middle-aged-and-older-hispanic-latino-adults-hispanic-community-health-study-study-of-latinos-hchs-sol-results
#4
Alvaro Camacho, Wassim Tarraf, Daniel E Jimenez, Linda C Gallo, Patricia Gonzalez, Robert C Kaplan, Melissa Lamar, Tasneem Khambaty, Bharat Thyagarajan, Krista M Perreira, Rosalba Hernandez, Jianwen Cai, Martha L Daviglus, Sylvia Wassertheil-Smoller, Hector M González
OBJECTIVE: The purpose of this study is to examine the association between verbal learning, fluency, and processing speed with anxious depression symptomatology (ADS) among diverse Hispanics. We hypothesized an inverse association of anxious depression with neurocognition among Hispanics of different heritage. DESIGN: Data are from the Hispanic Community Health Study/Study of Latinos. The sample included 9,311participants aged 45-74 years (mean: 56.5 years). A latent class analysis of items from the Center for Epidemiological Studies for Depression scale and the Spielberger Trait Anxiety Inventory was used to derive an anxious depression construct...
July 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28655740/diabetes-in-a-large-dementia-cohort-clinical-characteristics-and-treatment-from-the-swedish-dementia-registry
#5
Juraj Secnik, Pavla Cermakova, Seyed-Mohammad Fereshtehnejad, Pontus Dannberg, Kristina Johnell, Johan Fastbom, Bengt Winblad, Maria Eriksdotter, Dorota Religa
OBJECTIVE: We aimed to investigate the differences in clinical characteristics and pharmacological treatment associated with the presence of diabetes in a large cohort of patients with dementia. RESEARCH DESIGN AND METHODS: A cross-sectional registry-based study was conducted using data from the Swedish Dementia Registry (SveDem). Data on dementia diagnosis, dementia type, and demographic determinants were extracted from SveDem. Data from Swedish Patient Register and Prescribed Drug Register were combined for the diagnosis of diabetes...
June 27, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28632121/anti-inflammatory-treatment-and-risk-for-depression-after-first-time-stroke-in-a-cohort-of-147-487-danish-patients
#6
Ida Kim Wium-Andersen, Marie Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
BACKGROUND: Depression is a common complication after stroke, and inflammation may be a pathophysiological mechanism. This study examines whether anti-inflammatory treatment with acetylsalicylic acid (ASA), nonsteroid anti-inflammatory drugs (NSAID) or statins influence the risk of depression after stroke. METHODS: A register-based cohort including all patients admitted to hospital with a first-time stroke from Jan. 1, 2001, through Dec. 31, 2011, and a nonstroke population with a similar age and sex distribution was followed for depression until Dec...
June 20, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28622660/assessing-the-effects-of-the-antidepressant-venlafaxine-to-fathead-minnows-exposed-to-environmentally-relevant-concentrations-over-a-full-life-cycle
#7
Joanne L Parrott, Chris D Metcalfe
Venlafaxine is an antidepressant drug that has been detected in municipal wastewater effluents at low μg/L concentrations. To assess the potential of this compound to affect the survival, development and reproductive capacity of fish, we exposed fathead minnow (Pimephales promelas) over a full lifecycle in a flow-through system to nominal venlafaxine concentrations of 0.88, 8.8, and 88 μg/L. Mean measured venlafaxine concentrations in these treatments were 1.0, 9.3 and 75 μg/L. During the 167-168 d exposure, no significant changes were observed in survival, or the weights and lengths of fathead minnows...
June 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28593691/psychopharmacological-treatment-of-psychotic-mania-and-psychotic-bipolar-depression-compared-to-non-psychotic-mania-and-non-psychotic-bipolar-depression
#8
Louise B Bjørklund, Henriette T Horsdal, Ole Mors, Christiane Gasse, Søren D Østergaard
OBJECTIVES: An evidence base for the treatment of mania and bipolar depression with psychotic symptoms is lacking. Nevertheless, clinicians may have a preference for treating episodes of bipolar disorder with or without psychotic symptoms in different ways, which is likely to reflect notions of differential efficacy of treatments between these subtypes. This study aimed to investigate whether the psychopharmacological treatment of psychotic and non-psychotic episodes of mania and bipolar depression, respectively, differs in clinical practice...
June 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28591782/sex-dependent-effects-of-stress-on-immobility-behavior-and-vta-dopamine-neuron-activity-modulation-by-ketamine
#9
Millie Rincón-Cortés, Anthony A Grace
Background: Stress constitutes a risk factor across several psychiatric disorders. Moreover, females are more susceptible to stress-related disorders, such as depression, than males. Although dopamine (DA) system underactivation is implicated in the pathophysiology of depression, little is known about the female DA system at baseline and post-stress. Methods: The effects of chronic mild stress (CMS) were examined on ventral tegmental area (VTA) DA neuron activity and forced swim test (FST) immobility by comparing male and female rats...
June 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28584860/integrative-analysis-of-sex-differences-in-the-rapid-antidepressant-effects-of-ketamine-in-preclinical-models-for-individualized-clinical-outcomes
#10
Samantha K Saland, Florian Duclot, Mohamed Kabbaj
In major depressive disorder, women exhibit higher lifetime prevalence and different antidepressant response rates than men, which illustrates the importance of examining individual differences in the pathophysiology of depression and therapeutic response. In recent years, the consideration of sex in related preclinical research has thus gained interest-particularly in light of novel evidence for rapid-acting antidepressants. Notably, the literature recently revealed a higher sensitivity of females to the antidepressant effects of the N-methyl-D-aspartate receptor antagonist ketamine, in both baseline and preclinical conditions...
April 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28580124/sex-dependent-effects-of-maternal-corticosterone-and-ssri-treatment-on-hippocampal-neurogenesis-across-development
#11
Aarthi R Gobinath, Joanna L Workman, Carmen Chow, Stephanie E Lieblich, Liisa A M Galea
BACKGROUND: Postpartum depression affects approximately 15% of mothers and represents a form of early life adversity for developing offspring. Postpartum depression can be treated with prescription antidepressants like fluoxetine (FLX). However, FLX can remain active in breast milk, raising concerns about the consequences of neonatal FLX exposure. The hippocampus is highly sensitive to developmental stress, and males and females respond differently to stress at many endpoints, including hippocampal plasticity...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28545507/psychotropic-drug-use-and-mortality-in-old-people-with-dementia-investigating-sex-differences
#12
Jon Brännström, Gustaf Boström, Erik Rosendahl, Peter Nordström, Håkan Littbrand, Hugo Lövheim, Yngve Gustafson
BACKGROUND: Psychotropic drugs are common among old people with dementia, and have been associated with increased mortality. Previous studies have not investigated sex differences in this risk. This study was conducted to analyse associations between the use of antipsychotics, antidepressants, and benzodiazepines and 2-year mortality in old people with dementia, and to investigate sex differences therein. METHODS: In total, 1037 participants (74% women; mean age, 89 years) with dementia were included from four cohort studies and followed for 2 years...
May 25, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28481169/a-comparison-of-sexual-side-effects-of-antidepressants-with-and-without-naltrexone
#13
Mona Thapa, Ismene Petrakis, Elizabeth Ralevski
OBJECTIVE: The aim of the study was to compare the rate of sexual side effects of the selective serotonin reuptake inhibitor paroxetine versus the tricyclic antidepressant desipramine and to examine the effect of co-prescription of naltrexone on sexual side effects among participants in a randomized clinical trial. METHODS: This was a secondary analysis (N = 88) of veterans who participated in a 12-week trial. All veterans were randomized into one of four treatment groups: (a) desipramine/naltrexone, (b) desipramine/placebo, (c) paroxetine/naltrexone, and (d) paroxetine/placebo...
May 8, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28433385/perioperative-risks-of-narcolepsy-in-patients-undergoing-general-anesthesia-a-case-control-study
#14
Alexandre N Cavalcante, Ryan E Hofer, Maja Tippmann-Peikert, Juraj Sprung, Toby N Weingarten
STUDY OBJECTIVE: To compare the perioperative outcomes between patients with narcolepsy and matched controls undergoing anesthetic management. DESIGN: Retrospective 2:1 matched study design. SETTING: Large tertiary medical center. PATIENTS: Narcoleptic patients who underwent general anesthesia from January 1, 2011, through September 30, 2015, were matched with controls by age, sex, and type and year of surgery. MEASUREMENTS: Medical records were reviewed for episodes of respiratory depression during phase I recovery and for other meaningful perioperative outcomes...
April 19, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28384235/risk-analysis-of-use-of-different-classes-of-antidepressants-on-subsequent-dementia-a-nationwide-cohort-study-in-taiwan
#15
Chee-Kin Then, Nai-Fang Chi, Kuo-Hsuan Chung, Lynn Kuo, Kao-Hui Liu, Chaur-Jong Hu, Shing-Chuan Shen, Yen-Kuang Lin
Depression and dementia are common mental health problems and are associated in several ways. Early-life depression is associated with increased risk of later life dementia, and depression can present as a preclinical symptom or consequence of dementia. Despite the plausible relationship between these two clinical entities, the potential association between antidepressant medication and dementia has rarely been investigated. We conducted a 9-year retrospective analysis of Taiwan's National Health Insurance Research Database (NHIRD), enrolling 5819 cases who had received prescriptions of antidepressants between 2003 and 2006, and 23,276 (with ratio of 1:4) age, sex, and index date-matched controls...
2017: PloS One
https://www.readbyqxmd.com/read/28342066/antidepressant-use-in-suicides-a-case-control-study-from-the-friuli-venezia-giulia-region-italy-2005-2014
#16
Giulio Castelpietra, Michele Gobbato, Francesca Valent, Clarissa De Vido, Matteo Balestrieri, Göran Isacsson
PURPOSE: To compare the use of antidepressant (AD) classes and compounds in individuals who committed suicide and in controls from the general population and to assess to what extent adherence and current use of different AD classes can affect the risk of committing suicide. METHODS: Individual data on suicide, diagnoses and AD use in Friuli Venezia Giulia from 2005 to 2014 were obtained from the Regional Social and Health Information System. All suicides that had at least one prescription of AD in the 730 days before death (N = 876) were included as cases...
July 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28301398/a-pilot-study-cardiac-parameters-in-children-receiving-new-generation-antidepressants
#17
Mai Uchida, Andrea E Spencer, Tara Kenworthy, James Chan, Maura Fitzgerald, Ana Maria Rosales, Elana Kagan, Alexandra Saunders, Joseph Biederman
OBJECTIVE: Because of concerns about potential associations between high doses of citalopram and QTc prolongation in adults, this study examined whether such associations are operant in children. We hypothesized that therapeutic doses of nontricyclic antidepressant medications (non-TCAs) prescribed to children would be cardiovascularly safe. STUDY DESIGN: The sample consisted of 49 psychiatrically referred children and adolescents 6 to 17 years old of both sexes treated with a non-TCA (citalopram, escitalopram, fluoxetine, paroxetine, sertraline, bupropion, duloxetine, venlafaxine, mirtazapine)...
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28285255/relationships-between-circadian-measures-depression-and-response-to-antidepressant-treatment-a-preliminary-investigation
#18
Leslie M Swanson, Helen J Burgess, Edward D Huntley, Holli Bertram, Ann Mooney, Jennifer Zollars, Richard Dopp, Robert Hoffmann, Roseanne Armitage, J Todd Arnedt
Few studies have examined relationships between circadian rhythms and unipolar major depressive disorder. Further, no study to date has examined circadian markers as predictors of response to depression treatment. In the present study, we examined associations between circadian timing and its alignment with sleep and depression severity in 30 adults with major depressive disorder who completed a randomized controlled trial of two weeks of time in bed (TIB) restriction administered adjunctive to fluoxetine, with a focus on sex differences...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28281386/effects-of-depression-and-melatonergic-antidepressant-treatment-alone-and-in-combination-with-sedative-hypnotics-on-heart-rate-variability-implications-for-cardiovascular-risk
#19
Chuan-Chia Chang, Nian-Sheng Tzeng, Chin-Bin Yeh, Terry B J Kuo, San-Yuan Huang, Hsin-An Chang
OBJECTIVES: To examine heart rate variability (HRV) in unmedicated patients with major depressive disorder (MDD) and its changes after treatment with agomelatine alone and in combination with sedative-hypnotics. METHODS: We recruited 152 physically healthy, unmedicated patients with MDD and 472 age- and sex-matched healthy volunteers. Frequency-domain measures of HRV were obtained during enrolment for all participants and again for MDD patients after 6 weeks of treatment with agomelatine alone and combining sedative-hypnotics...
March 10, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28264149/hippocampal-%C3%AE-7-nicotinic-ach-receptors-contribute-to-modulation-of-depression-like-behaviour-in-c57bl-6j-mice
#20
Yann S Mineur, Tenna N Mose, Sam Blakeman, Marina R Picciotto
BACKGROUND AND PURPOSE: Clinical studies have identified links between cholinergic signalling and depression in human subjects. Increased cholinergic signalling in hippocampus also increases behaviours related to anxiety and depression in mice, which can be reversed by ACh receptor antagonists. EXPERIMENTAL APPROACH: As the α7 subunit of the nicotinic ACh receptor (nAChR) is highly expressed in hippocampus, we determined whether blocking α7 nAChRs could reverse the effects of increased ACh signalling in anxiety- and depression-related behaviours in mice...
March 6, 2017: British Journal of Pharmacology
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