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Sex differences, antidepressant

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https://www.readbyqxmd.com/read/29239976/abnormalities-of-p300-before-and-after-antidepressant-treatment-in-depression-an-erp-sloreta-study
#1
Lina Zhou, Gaohua Wang, Huiling Wang
Despite a wide range of reports on depression-induced P300 changes, it is still debatable whether P300 can return to a pattern characteristic of healthy individuals following antidepressant treatment. Thus, the present study aims to compare P300 and its underlying neural activation in depressed patients before and after antidepressant treatment to explore the brain regions related to pathogenesis and to evaluate the prognosis after treatment. P300 was evoked by the oddball auditory paradigm and collected from 14 sex-matched, age-matched, and education level-matched patients and controls...
December 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/29238228/prenatal-exposure-to-antipsychotic-medication-and-use-of-primary-health-care-system-in-childhood-a-population-based-cohort-study-in-denmark
#2
Anne Mette Lund Würtz, Claus Høstrup Vestergaard, Dorte Rytter, Merete Juul Sørensen, Jakob Christensen, Mogens Vestergaard, Bodil Hammer Bech
Background: Antipsychotic (AP) medication is increasingly used for many health conditions. Prenatal exposure to AP medication has been associated with several adverse outcomes, but the findings remain inconsistent. Purpose: We aimed to investigate prenatal exposure to AP medication and the use of primary health care system in childhood. Subjects and methods: All live-born singletons in Denmark during 1997-2012 were identified in the nationwide Danish National Patient Register and followed until December 31, 2013 (n = 963,010)...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29197324/altered-phosphorylation-electrophysiology-and-behavior-on-attenuation-of-pde4b-action-in-hippocampus
#3
Susan L Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot, Graeme B Bolger
BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3', 5' cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions. The PDE4 isoform PDE4B1 also interacts with the DISC1 protein, implicated in neural development and behavioral disorders. The cellular functions of PDE4B1 have been investigated extensively, but its function(s) in the intact organism remained unexplored...
December 2, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/29189941/vortioxetine-clinical-pharmacokinetics-and-drug-interactions
#4
REVIEW
Grace Chen, Astrid-Maria Højer, Johan Areberg, George Nomikos
Vortioxetine is a novel antidepressant with multimodal activity currently approved for the treatment of major depressive disorder. Vortioxetine is orally administered once daily at 5- to 20-mg doses. The pharmacokinetics of vortioxetine are linear and dose proportional, with a mean terminal half-life of approximately 66 h and steady-state plasma concentrations generally achieved within 2 weeks of dosing. The mean absolute oral bioavailability of vortioxetine is 75%. No food effect on pharmacokinetics was observed...
November 30, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29175721/de-masking-oxytocin-deficiency-in-craniopharyngioma-and-assessing-its-link-with-affective-function
#5
Dorothea Gebert, Matthias K Auer, Mareike R Stieg, Martin T Freitag, Madlén Lahne, Johannes Fuss, Katharina Schilbach, Jochen Schopohl, Günter K Stalla, Anna Kopczak
Despite the high prevalence of panhypopituitarism and diabetes insipidus in patients with craniopharyngioma (CP), little is known about the functioning of the neuropeptide oxytocin in these patients. This is of special interest as tumor-associated lesions often impair sites critical for oxytocin production and release, and affective dysfunction in CP links with elsewhere reported prosocial, antidepressant and anxiolytic oxytocin effects. Using a prospective study-design, we tested whether oxytocin is reduced in CP-patients, and whether altered oxytocin levels account for affective and emotional dysfunction...
November 14, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29175352/behavioral-and-biochemical-sensitivity-to-low-doses-of-ketamine-influence-of-estrous-cycle-in-c57bl-6-mice
#6
Amanda M Dossat, Katherine N Wright, Caroline E Strong, Mohamed Kabbaj
RATIONALE: Low-dose ketamine is a rapid-acting antidepressant, to which female rodents are more sensitive as compared to males. However, the mechanism mediating this sex difference in ketamine sensitivity remains elusive. OBJECTIVES: We sought to determine whether male and female mice differ in their behavioral sensitivity to low doses of ketamine, and uncover how ovarian hormones influence females' ketamine sensitivity. We also aimed to uncover some of the molecular mechanism(s) in mood-related brain regions that mediate sex differences in ketamine antidepressant effects...
November 21, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29163055/study-of-sex-differences-in-duloxetine-efficacy-for-depression-in-transgenic-mouse-models
#7
Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Gang Wang, Rena Li
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on endogenous estrogen level remain elusive. The aim of this study is to explore the molecular mechanisms of sex differences in antidepressant duloxetine. In the present study, we used genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene as models for endogenous estrogen deficiency and elevation endogenous estrogen, respectively, to examine the anti-depressive efficacy of duloxetine in males and females by force swimming test (FST)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29151792/fluoxetine-modulates-sex-steroid-levels-in-vitro
#8
Diana Lupu, Marcus O D Sjödin, Mukesh Varshney, Johan Lindberg, Felicia Loghin, Joëlle Rüegg
Background and aims: Selective serotonin reuptake inhibitors (SSRIs) are antidepressants increasingly prescribed against depression during and after pregnancy. However, these compounds cross the placenta and are found in breast milk, thus reaching, and possibly affecting, the fetus and infant during critical developmental stages. Fluoxetine (FLX), a widely used SSRI, can interfere with estrogen signaling, which is important for the development of female sex organs and certain brain areas, among others...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29120143/restless-legs-syndrome-in-multiple-sclerosis-patients-%C3%A2-patient-experience-at-lipik-special-hospital-for-medical-rehabilitation
#9
Merisanda Časar Rovazdi, Viktor Vidović, Oto Kraml, Vanja Bašić Kes
The study included 60 patients with multiple sclerosis (MS) hospitalized at our institution from September 1 to December 31, 2014. The aim of the study was to assess the prevalence of restless legs syndrome (RLS) in MS patients and RLS relationship with patient age, sex, degree of disability, form of MS, time elapsed from MS diagnosis and use of antidepressants. The diagnosis of RLS was made according to the criteria set by the International Restless Legs Syndrome Study Group. Of the 60 patients, 24 (40%) met the criteria for the existence of RLS...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29104538/chronic-treatment-with-fluoxetine-induces-sex-dependent-analgesic-effects-and-modulates-hdac2-and-mglu2-expression-in-female-mice
#10
Magda Zammataro, Sara Merlo, Massimo Barresi, Carmela Parenti, Huijuan Hu, Maria A Sortino, Santina Chiechio
Gender and sex differences in pain recognition and drug responses have been reported in clinical trials and experimental models of pain. Among antidepressants, contradictory results have been observed in patients treated with selective serotonin reuptake inhibitors (SSRIs). This study evaluated sex differences in response to the SSRI fluoxetine after chronic administration in the mouse formalin test. Adult male and female CD1 mice were intraperitoneally injected with fluoxetine (10 mg/kg) for 21 days and subjected to pain assessment...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29075577/effects-of-hint1-deficiency-on-emotional-like-behaviors-in-mice-under-chronic-immobilization-stress
#11
Liankang Sun, Peng Liu, Fei Liu, Yuan Zhou, Zheng Chu, Yuqi Li, Guang Chu, Ying Zhang, Jiabei Wang, Yong-Hui Dang
BACKGROUND: Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender-specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain-derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29054014/sex-differences-in-behavioral-and-neurochemical-effects-of-gonadectomy-and-aromatase-inhibition-in-rats
#12
N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dalla
Aromatase inhibitors, which are widely used for the treatment of estrogen-dependent cancers, have been associated with psychiatric side effects ranging from mania to depression. In the present study, we investigated sex differences in the behavioral and neurochemical effects of aromatase inhibition on male and female, sham-operated or gonadectomized adult rats. Three weeks after surgery, rats received chronic treatment with the aromatase inhibitor letrozole or vehicle and were then subjected to the open field test, which assesses general activity...
October 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28916143/violent-behavior-by-emergency-department-patients-with-an-involuntary-hold-status
#13
Nancy L Dawson, Christian Lachner, Tyler F Vadeboncoeur, Michael J Maniaci, Veronica Bosworth, Teresa A Rummans, Archana Roy, M Caroline Burton
BACKGROUND: Violence against health care workers has been increasing. Health care workers in emergency departments (EDs) are highly vulnerable because they provide care for patients who may have mental illness, behavioral problems, or substance use disorders (alone or in combination) and who are often evaluated during an involuntary hold. Our objective was to identify factors that may be associated with violent behavior in ED patients during involuntary holds. METHODS: Retrospective review of patients evaluated during an involuntary hold at a suburban acute care hospital ED from January 2014 through November 2015...
August 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28875615/prescription-trends-of-psychotropics-in-children-and-adolescents-with-autism-based-on-nationwide-health-insurance-data
#14
Minha Hong, Seung Yup Lee, Juhee Han, Jin Cheol Park, Yeon Jung Lee, Ram Hwangbo, Hyejung Chang, Seong Woo Cho, Soo Young Bhang, Bongseog Kim, Jun Won Hwang, Geon Ho Bahn
Children with autism are often medicated to manage emotional and behavioral symptoms; yet, data on such pharmacotherapy is insufficient. In this study, we investigated the Korean National Health Insurance Claims Database (NHICD) information related to autism incidence and psychotropic medication use. From the 2010-2012 NHICD, we selected a total of 31,919,732 subjects under 19 years old. To examine the diagnostic incidence, we selected patients who had at least one medical claim containing an 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) code for pervasive developmental disorder, F84, not diagnosed in the previous 360 days...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28864716/trajectories-and-characteristics-of-work-disability-before-and-after-acute-myocardial-infarction
#15
Mo Wang, Marjan Vaez, Thomas Ernst Dorner, Jari Tiihonen, Margaretha Voss, Torbjörn Ivert, Ellenor Mittendorfer-Rutz
OBJECTIVE: Scientific knowledge on work disability in terms of sickness absence and disability pension (SA/DP) among patients with acute myocardial infarction (AMI) is scarce. The study aimed to investigate trajectories of SA/DP among individuals with or without AMI and examined the associations between sociodemographic, morbidity and coronary revascularisation characteristics with such trajectories among patients with AMI. METHODS: This is a population-based cohort study of 10 255 individuals aged 30-60 years who had a first AMI during 2008-2010 and were alive 30 days after AMI...
September 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28860772/factors-associated-with-failure-to-achieve-remission-and-with-relapse-after-remission-in-patients-with-major-depressive-disorder-in-the-perform-study
#16
Delphine Saragoussi, Maëlys Touya, Josep Maria Haro, Bengt Jönsson, Martin Knapp, Bastien Botrel, Ioana Florea, Henrik Loft, Benoît Rive
BACKGROUND: The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28840629/extent-and-risks-of-antidepressant-off-label-use-in-children-and-adolescents-in-germany-between-2004-and-2011
#17
Carsten Schröder, Michael Dörks, Bianca Kollhorst, Tilo Blenk, Ralf W Dittmann, Edeltraut Garbe, Oliver Riedel
PURPOSE: So far, only little is known about antidepressant off-label use in pediatric patients. This is the first study examining the prevalence and the risks of off-label antidepressant prescriptions in minors over time in Germany and analyzing patterns regarding age, sex, drug class, and type of off-label use. METHODS: We used claims data of about two million individuals (<18 y) to calculate the share of off-label antidepressant prescriptions for the years 2004 to 2011, stratified by age, sex, and drug class...
August 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28837274/association-between-bone-mineral-density-and-depressive-symptoms-in-a-population-based-sample
#18
Rocco D Hlis, Roger S McIntyre, Naim M Maalouf, Erin Van Enkevort, E Sherwood Brown
OBJECTIVE: This analysis was conducted to determine the relationship between bone mineral density (BMD) and depressive symptoms in a population-based cohort. METHODS: Data were extracted from the second phase of the Dallas Heart Study (DHS-2), a large, multiethnic population sample in Dallas County, Texas, from September 1, 2007, to December 31, 2009. Depressive symptom severity was measured with the 16-item Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR₁₆), which is derived from DSM-IV major depressive disorder criteria...
August 22, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28826680/patient-characteristics-associated-with-quality-of-colonoscopy-preparation-a-systematic-review-and-meta-analysis
#19
Kunjal Gandhi, Christina Tofani, Carly Sokach, Devin Patel, David Kastenberg, Constantine Daskalakis
BACKGROUND & AIMS: Some features of patients are associated with inadequate bowel preparation, which reduces the effectiveness of colonoscopy examination. We performed a systematic review and meta-analysis of the association between patients' sociodemographic characteristics, health conditions, and medications with inadequate bowel preparation. METHODS: We searched the PubMed, Scopus, and Cochrane Review databases for randomized controlled trials and cohort (prospective and retrospective), case-control, and cross-sectional studies published through March 2016...
August 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28796415/white-matter-tract-integrity-is-associated-with-antidepressant-response-to-lurasidone-in-bipolar-depression
#20
Martin J Lan, Harry Rubin-Falcone, Fatima Motiwala, Ying Chen, Jonathan W Stewart, David J Hellerstein, J John Mann, Patrick J McGrath
OBJECTIVES: Patients with bipolar disorder spend the most time in the depressed phase, and that phase is associated with the most morbidity and mortality. Treatment of bipolar depression lacks a test to determine who will respond to treatment. White matter disruptions have been found in bipolar disorder. Previous reports suggest that white matter disruptions may be associated with resistance to antidepressant medication, but this has never been investigated in a prospective study using a Food and Drug Administration (FDA)-approved medication...
September 2017: Bipolar Disorders
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