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https://www.readbyqxmd.com/read/29224691/musculoskeletal-health-conditions-among-older-populations-in-urban-slums-in-sub-saharan-africa
#1
REVIEW
Isabella Aboderin, Agnes Nanyonjo
BACKGROUND: Debate on the burden of musculoskeletal (MSK) conditions in lower and middle income countries is intensifying; yet, little knowledge so far exists on patterns and impacts of such conditions among general or older adult populations in sub-Saharan Africa (SSA). The objectives of this study are to examine the prevalence, potential predictors, and sequelae of MSK among older adults residing in two low resource informal urban settlements or "slums" in Nairobi Kenya. METHODS: Data on older adults aged 60 years and over from two unrelated cross-sectional surveys on the older slum populations are used: a 2006/7 survey on the social, health, and overall well-being of older people (sample N = 831), and a 2016 survey on realities and impacts of long-term care and social protection for older adults (sample n = 1026)...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29219856/the-interaction-of-depressive-symptoms-and-hazardous-drinking-in-relation-to-tobacco-craving-among-treatment-seeking-depressed-smokers-sex-differences
#2
Rubén Rodríguez-Cano, Ana López-Durán, Daniel J Paulus, Carmela Martínez-Vispo, Elena Fernández Del Río, Elisardo Becoña, Michael J Zvolensky
OBJECTIVES: The present study sought to address whether there is sex effect in the interactive effect between depressive symptoms and hazardous drinking in the prediction of smoking craving after cognitive-behavioral smoking cessation treatment among those with at least mild depression. METHODS: Participants (n = 114, mean age 42.0, SD = 9.73, 64% women) were treatment-seeking smokers who attended 6 weekly 1-hour sessions involving psychological treatment for cessation...
December 6, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29215693/adolescent-depression-in-jordan-symptoms-profile-gender-differences-and-the-role-of-social-context
#3
Latefa Ali Dardas, Susan G Silva, Moria J Smoski, Devon Noonan, Leigh Ann Simmons
The influence of gender and other individual and context characteristics on the prevalence and severity of depressive symptoms among Jordanian adolescents remains unclear. The aims of the current study were to: (a) characterize depressive symptoms profiles for Jordanian adolescents; and (b) examine gender differences in the type, severity, and correlates of depressive symptoms. Cross-sectional data were collected from 2,349 Jordanian adolescents ages 12 to 17 using a nationally representative school survey...
December 6, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29194444/behavioral-stress-alters-corticolimbic-microglia-in-a-sex-and-brain-region-specific-manner
#4
Justin L Bollinger, Kaitlyn E Collins, Rushi Patel, Cara L Wellman
Women are more susceptible to numerous stress-linked psychological disorders (e.g., depression) characterized by dysfunction of corticolimbic brain regions critical for emotion regulation and cognitive function. Although sparsely investigated, a number of studies indicate sex differences in stress effects on neuronal structure, function, and behaviors associated with these regions. We recently demonstrated a basal sex difference in- and differential effects of stress on- microglial activation in medial prefrontal cortex (mPFC)...
2017: PloS One
https://www.readbyqxmd.com/read/29194059/self-reported-mild-traumatic-brain-injuries-in-relation-to-rumination-and-depressive-symptoms-moderating-role-of-sex-differences-and-a-brain-derived-neurotrophic-factor-gene-polymorphism
#5
Robert L Gabrys, Kaylyn Dixon, Matthew R Holahan, Hymie Anisman
OBJECTIVE: Mild traumatic brain injuries (mTBIs) have frequently been associated with the emergence and persistence of depressive symptoms. However, the factors which contribute to the increased risk for depression after these head injuries remain unclear. Accordingly, we examined the relationship between frequency of self-reported mTBIs and current symptoms of depression and the mediating role of rumination and cognitive flexibility. We also examined whether these relations were moderated by sex differences and the presence of the Val66Met polymorphism in a gene coding for brain-derived neurotrophic factor (BDNF)...
November 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29193847/genetic-loss-of-diazepam-binding-inhibitor-in-mice-impairs-social-interest
#6
A L Ujjainwala, C D Courtney, S G Rhoads, J S Rhodes, C A Christian
Neuropsychiatric disorders in which reduced social interest is a common symptom, such as autism, depression, and anxiety, are frequently associated with genetic mutations affecting GABAergic transmission. Benzodiazepine treatment, acting via GABAA receptors, improves social interaction in male mouse models with autism-like features. The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described. Here we investigated the role of DBI in the social interest and recognition behavior of mice...
November 28, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29176954/response-to-commentary-sex-differences-in-the-peripheral-immune-system-in-patients-with-depression
#7
COMMENT
Badari Birur, Richard C Shelton, Ellen M Amrock, Li Li
No abstract text is available yet for this article.
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29173194/sex-similarities-and-differences-in-risk-factors-for-recurrence-of-major-depression
#8
Hanna M van Loo, Steven H Aggen, Charles O Gardner, Kenneth S Kendler
BACKGROUND: Major depression (MD) occurs about twice as often in women as in men, but it is unclear whether sex differences subsist after disease onset. This study aims to elucidate potential sex differences in rates and risk factors for MD recurrence, in order to improve prediction of course of illness and understanding of its underlying mechanisms. METHODS: We used prospective data from a general population sample (n = 653) that experienced a recent episode of MD...
November 27, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29163055/study-of-sex-differences-in-duloxetine-efficacy-for-depression-in-transgenic-mouse-models
#9
Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Gang Wang, Rena Li
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on endogenous estrogen level remain elusive. The aim of this study is to explore the molecular mechanisms of sex differences in antidepressant duloxetine. In the present study, we used genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene as models for endogenous estrogen deficiency and elevation endogenous estrogen, respectively, to examine the anti-depressive efficacy of duloxetine in males and females by force swimming test (FST)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29155264/modulation-of-adrenal-steroidogenesis-by-testosterone-in-the-lizard-coleonyx-elegans
#10
Rocco V Carsia, Patrick J McIlroy, Henry B John-Alder
Our previous work with adrenocortical cells from several Sceloporus lizard species suggests that gonadal hormones influence the steroidogenic capacity and the sensitivity to ACTH. However, there are discrepancies in these cellular response parameters suggesting that the effects of gonadal hormones on adrenocortical function vary with species, sex, age, season, and environmental/experimental conditions. To gain further insight into these complex interactions, here we report studies on Coleonyx elegans, Eublepharidae (Yucatán Banded Gecko), which is only distantly related to Sceloporus lizards via a basal common ancestor and in captivity, reproduces throughout the year...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29123970/physiological-markers-of-interpersonal-stress-generation-in-depression
#11
Jessica L Hamilton, Lauren B Alloy
Abnormalities in parasympathetic nervous system activity have been linked to depression, but less is known about processes underlying this relationship. The present study evaluated resting and stress-reactive respiratory sinus arrhythmia (RSA) to a laboratory stressor as predictors of daily interpersonal stress generation and depressive symptoms, whether stress generation mediated the relationship between RSA and depressive symptoms, and potential sex differences. A sample of formerly depressed 102 emerging adults (18-22 years; 78% female) completed a laboratory stressor and daily assessments of stressors and depressive symptoms over two weeks...
2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/29117647/personality-changes-following-brain-artery-aneurysm-surgery
#12
Ljiljana Pačić-Turk, Tena Šulentić, Ana Havelka Meštrović, Josip Paladino, Goran Mrak
Neuropsychological testing of patients in the course of their recovery from brain injuries enables analysis of cognitive deficiencies and/or emotional changes. The principle study objective was to define organic and/or reactive personality changes and the course of these changes in the function of the time span following brain artery aneurysm surgery in both female and male patients. The study was carried out at the Clinical Department of Neurosurgery, Zagreb University Hospital Center in Zagreb. The data refer to the period from 1989 to 2012 collected in two time intervals, i...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29090856/timing-of-maternal-depression-and-sex-specific-child-growth-the-upstate-kids-study
#13
Hyojun Park, Rajeshwari Sundaram, Stephen E Gilman, Griffith Bell, Germaine M Buck Louis, Edwina H Yeung
OBJECTIVE: Equivocal findings have been reported on the association between maternal depression and children's growth, possibly because of the limited attention to its disproportionate impact by child sex. The relationship between the timing of maternal depression and children's growth was assessed in a population-based prospective birth cohort, with particular attention to sex differences. METHODS: The Upstate KIDS Study comprised 4,394 children followed through 3 years of age from 2008 to 2010...
November 1, 2017: Obesity
https://www.readbyqxmd.com/read/29084311/work-family-conflict-and-the-sex-difference-in-depression-among-training-physicians
#14
Constance Guille, Elena Frank, Zhuo Zhao, David A Kalmbach, Paul J Nietert, Douglas A Mata, Srijan Sen
Importance: Depression is common among training physicians and may disproportionately affect women. The identification of modifiable risk factors is key to reducing this disease burden and its negative impact on patient care and physician career attrition. Objective: To determine the presence and magnitude of a sex difference in depressive symptoms and work-family conflict among training physicians; and if work-family conflict impacts the sex difference in depressive symptoms among training physicians...
October 30, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29083382/do-sex-differences-in-respiratory-burst-enzyme-activities-exist-in-human-immunodeficiency-virus-1-infection
#15
Mathias Abiodun Emokpae, Beatrice Aghogho Mrakpor
Studies have shown that human immunodeficiency virus type 1 (HIV-1) disproportionally affects more females than males. Affected individuals are susceptible to infections due to depressed immunity, qualitative defects in phagocytic function and altered phagocytosis as well as lowered oxidative burst capacity. This study seeks to determine whether sex differences exist in serum activities of respiratory burst enzymes in HIV-1-infected female and male subjects. Serum myeloperoxidase, catalase and superoxide dismutase activities were assayed in 170 confirmed HIV-1 positive and 50 HIV-1 negative subjects using ELISA...
November 15, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29075577/effects-of-hint1-deficiency-on-emotional-like-behaviors-in-mice-under-chronic-immobilization-stress
#16
Liankang Sun, Peng Liu, Fei Liu, Yuan Zhou, Zheng Chu, Yuqi Li, Guang Chu, Ying Zhang, Jiabei Wang, Yong-Hui Dang
BACKGROUND: Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender-specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain-derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29073752/rora-polymorphism-interacts-with-childhood-maltreatment-in-determining-anxiety-sensitivity-by-sex-a-preliminary-study-in-healthy-young-adults
#17
Jung-Ah Min, Heon-Jeong Lee, Seung-Hwan Lee, Young-Min Park, Seung-Gul Kang, Young-Gyu Park, Jeong-Ho Chae
Objective: Recent studies have reported associations of retinoid-related orphan receptor alpha (RORA) gene single nucleotide polymorphisms (SNPs) with depression and anxiety disorders. Based on these, we attempt to test whether RORA polymorphism is associated with anxiety sensitivity (AS), the intermediate phenotype of depression and anxiety disorders. Considering gene-environment interactions and sex differences in AS, childhood maltreatment (CM) and sex were considered as confounders...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29064839/sex-differences-in-the-association-between-a-previous-cancer-diagnosis-and-the-use-of-medication
#18
Ana Rute Costa, Luís Pacheco-Figueiredo, Luís Alves, Nuno Lunet
We aimed to quantify the association between a previous cancer diagnosis and medication use, depicting possible sex differences. We analysed data from a representative sample of the Portuguese adult population (n=32 610), which was collected through face-to-face interviews, using a structured questionnaire. The effect of a previous diagnosis of cancer was quantified through prevalence ratios (PR), adjusted for age, education and region of residence. Cancer survivors (CS) reported higher use of prescribed medication, with greater adjusted PR among men (1...
October 23, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29061855/depression-and-mortality-in-a-longitudinal-study-1952-2011
#19
Stephen E Gilman, Ewa Sucha, Mila Kingsbury, Nicholas J Horton, Jane M Murphy, Ian Colman
BACKGROUND: Many studies have shown that depression increases mortality risk. We aimed to investigate the duration of time over which depression is associated with increased risk of mortality, secular trends in the association between depression and mortality, and sex differences in the association between depression and mortality. METHODS: We conducted a cohort study of 3410 adults enrolled in 3 representative samples of a county in Atlantic Canada in 1952 (n = 1003), 1970 (n = 1203) or 1992 (n = 1402) (the Stirling County Study)...
October 23, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29054032/constipation-and-other-common-symptoms-reported-by-women-and-men-in-methadone-and-buprenorphine-maintenance-treatment
#20
Paul S Haber, Mahmoud Elsayed, David Espinoza, Nicholas Lintzeris, Anne-Sophie Veillard, Richard Hallinan
BACKGROUND: Opioid substitution treatment (OST) is often continued long-term and, therefore, opioid-associated symptoms are of interest. Symptoms associated with methadone maintenance treatment (MMT) in men are well described, but there are fewer reports concerning symptoms associated with buprenorphine maintenance treatment (BMT) and very few reports among women. METHOD: Recipients of BMT (n=113) and MMT (n=184), non-opioid users (n=105) and opioid users not receiving OST (n=87) completed the Patient Assessment of Constipation (PAC-SYM) and a general symptom checklist...
October 13, 2017: Drug and Alcohol Dependence
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