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https://www.readbyqxmd.com/read/29054032/constipation-and-other-common-symptoms-reported-by-women-and-men-in-methadone-and-buprenorphine-maintenance-treatment
#1
Paul S Haber, Mahmoud Elsayed, David Espinoza, Nicholas Lintzeris, Anne-Sophie Veillard, Richard Hallinan
BACKGROUND: Opioid substitution treatment (OST) is often continued long-term and, therefore, opioid-associated symptoms are of interest. Symptoms associated with methadone maintenance treatment (MMT) in men are well described, but there are fewer reports concerning symptoms associated with buprenorphine maintenance treatment (BMT) and very few reports among women. METHOD: Recipients of BMT (n=113) and MMT (n=184), non-opioid users (n=105) and opioid users not receiving OST (n=87) completed the Patient Assessment of Constipation (PAC-SYM) and a general symptom checklist...
October 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29054014/sex-differences-in-behavioral-and-neurochemical-effects-of-gonadectomy-and-aromatase-inhibition-in-rats
#2
N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dalla
Aromatase inhibitors, which are widely used for the treatment of estrogen-dependent cancers, have been associated with psychiatric side effects ranging from mania to depression. In the present study, we investigated sex differences in the behavioral and neurochemical effects of aromatase inhibition on male and female, sham-operated or gonadectomized adult rats. Three weeks after surgery, rats received chronic treatment with the aromatase inhibitor letrozole or vehicle and were then subjected to the open field test, which assesses general activity...
October 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29038777/the-abcd-study-of-neurodevelopment-identifying-neurocircuit-targets-for-prevention-and-treatment-of-adolescent-substance-abuse
#3
James M Bjork, Lisa K Straub, Rosellen G Provost, Michael C Neale
Substance use disorders (SUD) can be considered developmental disorders in light of their frequent origins in substance initiation during adolescence. Cross-sectional functional magnetic resonance imaging (fMRI) studies of adolescent substance users or adolescents with SUD have indicated aberrations in brain structures or circuits implicated in motivation, self-control, and mood-regulation. However, attributing these differences to the neurotoxicological effects of chronic substance use has been problematic in that these circuits are also aberrant in at-risk children, such as those with prenatal substance exposure, externalizing disorders (such as conduct disorder), or prodromal internalizing disorders such as depression...
June 2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29031183/childhood-hunger-and-depressive-symptoms-in-adulthood-findings-from-a-population-based-study
#4
Andrew Stickley, Mall Leinsalu
BACKGROUND: Several studies have linked childhood hunger to an increased risk for later depression. However, as yet, there has been little research on this relation in adults of all ages or whether there are sex differences in this association. The current study examined these issues using data from a national population-based sample. METHODS: Data were analyzed from 5095 adults aged 25-84 collected during the Estonian Health Interview Survey 2006. Information was obtained on the frequency of going to bed hungry in childhood and on depressive symptoms using the Emotional State Questionnaire (EST-Q)...
September 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28993631/establishment-of-a-repeated-social-defeat-stress-model-in-female-mice
#5
Aki Takahashi, Jia-Ru Chung, Song Zhang, Hongxing Zhang, Yael Grossman, Hossein Aleyasin, Meghan E Flanigan, Madeline L Pfau, Caroline Menard, Dani Dumitriu, Georgia E Hodes, Bruce S McEwen, Eric J Nestler, Ming-Hu Han, Scott J Russo
Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl)...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992584/ogt-related-mitochondrial-motility-is-associated-with-sex-differences-and-exercise-effects-in-depression-induced-by-prenatal-exposure-to-glucocorticoids
#6
Weina Liu, Hongmei Wang, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi, Liu Ji
BACKGROUND: Prenatal exposure to glucocorticoids (GCs) has been found to trigger abnormal behaviors and deleterious neurological effects on offspring both in animals and in humans. The sex differences in depression have been replicated in numerous studies across cultures, persisting throughout the reproductive years. As an X-linked gene in rodents and in humans, O-GlcNAc transferase (OGT) may provide a novel perspective for the sex differences in depression. METHODS: In the last third of pregnancy (gestational day 14-21), rats were subcutaneously administered either 0...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28992527/sex-differences-in-the-mediators-of-functional-disability-in-major-depressive-disorder
#7
Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Danielle S Cha, Yena Lee, Dominika Fus, Roger S McIntyre
The aim of this study was to investigate sex differences in discrete domains of psychopathology as mediators of functional disability among individuals with Major Depressive Disorder (MDD). Adults (ages 18-65) with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls (HC; n = 100) participated in a clinical trial validating the THINC-integrated tool, a newly developed cognitive assessment tool for patients with MDD. Variables assessed as possible mediators included depression symptom severity, anxiety symptoms, sleep disturbance, perceived cognitive deficits, and objective cognitive performance...
September 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#8
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28978356/is-the-hospital-anxiety-and-depression-scale-hads-a-valid-measure-in-a-general-population-65-80%C3%A2-years-old-a-psychometric-evaluation-study
#9
Ingrid Djukanovic, Jörg Carlsson, Kristofer Årestedt
BACKGROUND: The HADS (Hospital Anxiety and Depression Scale) aims to measure symptoms of anxiety (HADS Anxiety) and depression (HADS Depression). The HADS is widely used but has shown ambiguous results both regarding the factor structure and sex differences in the prevalence of depressive symptoms. There is also a lack of psychometric evaluations of the HADS in non-clinical samples of older people. The aim of the study was to evaluate the factor structure of the HADS in a general population 65-80 years old and to exam possible presence of differential item functioning (DIF) with respect to sex...
October 4, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28974457/sex-differences-in-stress-regulation-of-arousal-and-cognition
#10
Debra A Bangasser, Samantha R Eck, Alexander M Telenson, Madeleine Salvatore
There are sex differences in the prevalence and presentation of many psychiatric disorders. For example, posttraumatic stress disorder (PTSD) and major depression are more common in women than men, and women with these disorders present with more hyperarousal symptoms than men. In contrast, attention deficit hyperactivity (ADHD) and schizophrenia are more common in men than women, and men with these disorders have increased cognitive deficits compared to women. A shared feature of the aforementioned psychiatric disorders is the contribution of stressful events to their onset and/or severity...
September 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28954870/sex-and-estrus-dependent-differences-in-rat-basolateral-amygdala
#11
Shannon R Blume, Mari Freedberg, Jaime E Vantrease, Ronny Chan, Mallika Padival, Matthew J Record, M Regina DeJoseph, Janice H Urban, J Amiel Rosenkranz
Depression and anxiety are diagnosed almost twice as often in women, the symptomology differs in men and women and is sensitive to sex hormones. The basolateral amygdala (BLA) contributes to emotion-related behaviors that differ between males and females and across the reproductive cycle. This hints to sex- or estrus-dependent features of BLA function, about which very little is known. The purpose of this study was to test whether there are sex differences or estrous cyclicity in rat BLA physiology and to determine their mechanistic correlates...
September 27, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28954244/depressive-symptoms-are-associated-with-salivary-shedding-of-epstein-barr-virus-in-female-adolescents-the-role-of-sex-differences
#12
Jodi L Ford, Raymond P Stowe
BACKGROUND: Adolescent females have a higher prevalence of depression in comparison to their male peers - a disparity that has been increasing over the past decade. Depression is of concern as it is associated with chronic disease and to immune dysregulation, which may be one mechanism linking depression to future pathology. This study examined the extent to which sex moderated the association between depressive symptoms and immune dysregulation during adolescence using Epstein-Barr virus (EBV) reactivation, a biomarker of cellular immune response, as a model...
September 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28944102/sex-differences-in-suicide-related-symptoms-in-a-large-military-sample
#13
Megan L Rogers, Fallon B Ringer, Matthew S Michaels, Bruno Chiurliza, Christopher R Hagan, Carol Chu, Matthew E Schneider, Ingrid C Lim, Thomas E Joiner
Little research has focused on suicide-related symptoms in female servicemembers, despite high rates of suicidal behaviors. This study examined sex differences in suicide-related risk factors in 3,374 U.S. Army Recruiters (91.9% male). Female servicemembers had a greater number of past major depressive and suicidal ideation episodes than males; there were no differences in suicide attempt histories or mental health visits. Females reported significantly fewer symptoms of current suicidal ideation, perceived burdensomeness, and acquired capability...
2017: Military Behavioral Health
https://www.readbyqxmd.com/read/28942527/psychological-pathways-from-racial-discrimination-to-cortisol-in-african-american-males-and-females
#14
Daniel B Lee, Melissa K Peckins, Justin E Heinze, Alison L Miller, Shervin Assari, Marc A Zimmerman
The association between racial discrimination (discrimination) and stress-related alterations in the neuroendocrine response-namely, cortisol secretion-is well documented in African Americans (AAs). Dysregulation in production of cortisol has been implicated as a contributor to racial health disparities. Guided by Clark et al. (Am Psychol 54(10):805-816, 1999. doi: 10.1037/0003-066X.54.10.805 ) biopsychosocial model of racism and health, the present study examined the psychological pathways that link discrimination to total cortisol concentrations in AA males and females...
September 23, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28942288/differences-in-behavioral-health-disorders-and-unmet-treatment-needs-between-medical-marijuana-users-and-recreational-marijuana-users-results-from-a-national-adult-sample
#15
Ji-Yeun Park, Li-Tzy Wu
BACKGROUND: Available data suggest that medical marijuana users may have more mental health problems than recreational marijuana users. There is limited information about differences in behavioral health disorders and unmet treatment needs between medical and recreational marijuana users. METHODS: We compared past-year prevalence of behavioral health disorders and unmet treatment needs across three marijuana subgroups (recreational use only, medical use only, and both)...
November 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28939955/differences-in-clinical-characteristics-in-patients-with-first-st-segment-elevation-myocardial-infarction-and-ventricular-fibrillation-according-to-sex
#16
Reza Jabbari, Charlotte Glinge, Bjarke Risgaard, Thomas Hadberg Lynge, Bo Gregers Winkel, Stig Haunsø, Christine M Albert, Thomas Engstrøm, Jacob Tfelt-Hansen
PURPOSE: We aimed to assess sex differences in clinical characteristics, circumstances of arrest, and procedural characteristics in ST-elevation myocardial infarction (STEMI) patients with ventricular fibrillation (VF) prior to angioplasty. METHODS: Cases of VF with first STEMI (n = 329; 276 men and 53 women) were identified from the GEVAMI study, which is prospectively assembled case-control study among first STEMI patients in Denmark. RESULTS: Compared to men, women experienced symptoms for a longer time interval prior to angioplasty (140 vs...
September 22, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28937938/anxiety-and-depression-among-college-students-with-attention-deficit-hyperactivity-disorder-adhd-cross-informant-sex-and-subtype-differences
#17
Jason M Nelson, Spencer W Liebel
OBJECTIVE: This study examined symptoms of anxiety and depression among college students with attention-deficit/hyperactivity disorder (ADHD). PARTICIPANTS: Data were collected between March 2011 and March 2016 from 150 college students with ADHD and 150 college students without ADHD. METHOD: Participants with ADHD were compared to a sex- and ethnicity-matched control group. For the ADHD group, parent and self-report of anxiety and depression were also compared...
September 22, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28936020/predictors-of-depressive-symptoms-in-emerging-adulthood-in-a-low-income-urban-cohort
#18
Christina F Mondi, Arthur J Reynolds, Suh-Ruu Ou
This study examined predictors of depressive symptoms in emerging adulthood in a sample of 1,142 individuals (94% African American) who grew up in urban poverty. Data were drawn from a longitudinal study that followed participants from age five and included participant, parent, and teacher surveys, and administrative records. Depressive symptoms were self-reported at age 22-24 using a modified version of the Brief Symptom Inventory (BSI; Derogatis, 1975). Binary logistic regression analyses identified several significant predictors of depressive symptoms in emerging adulthood, including: sex, adverse childhood experiences (ACE) score, socio-emotional adjustment in the classroom, juvenile arrest, and on-time graduation...
May 2017: Journal of Applied Developmental Psychology
https://www.readbyqxmd.com/read/28912210/sex-differences-in-clinical-characteristics-psychosocial-factors-and-outcomes-among-patients-with-stable-coronary-heart-disease-insights-from-the-stability-stabilization-of-atherosclerotic-plaque-by-initiation-of-darapladib-therapy-trial
#19
Patricia Oliveira Guimarães, Christopher B Granger, Amanda Stebbins, Karen Chiswell, Claes Held, Judith S Hochman, Susan Krug-Gourley, Eva Lonn, Renato D Lopes, Ralph A H Stewart, Dragos Vinereanu, Lars Wallentin, Harvey D White, Emil Hagström, Nicolas Danchin
BACKGROUND: Greater understanding of differences between men and women with coronary heart disease is needed. METHODS AND RESULTS: In this post hoc analysis of the STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, we described psychosocial factors, treatments, and outcomes of men versus women with stable coronary heart disease and explored the association of sex with psychosocial characteristics and cardiovascular risk...
September 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28904986/sex-matters-repetitive-mild-traumatic-brain-injury-in-adolescent-rats
#20
David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk
OBJECTIVE: Whether sex differences contribute to the heterogeneity of mild traumatic brain injury (mTBI) and repeated mTBI (RmTBI) outcomes in adolescents is unknown. Therefore, this study examined changes in, and differences between, male and female rats following single mTBI and RmTBI. METHODS: Rats were given a single mTBI, RmTBI (i.e., 3x), or sham injuries. Injuries were administered using a lateral impact model that mimics forces common in human mTBI. After the final injury, rats underwent extensive behavioral testing to examine cognition, motor function, and anxiety- and depressive-like behavior...
September 2017: Annals of Clinical and Translational Neurology
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