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https://www.readbyqxmd.com/read/28625549/the-long-term-effects-of-stress-and-kappa-opioid-receptor-activation-on-conditioned-place-aversion-in-male-and-female-california-mice
#1
Abigail R Laman-Maharg, Tiffany Copeland, Evelyn Ordoñes Sanchez, Katharine L Campi, Brian C Trainor
Psychosocial stress leads to the activation of kappa opioid receptors (KORs), which induce dysphoria and facilitate depression-like behaviors. However, less is known about the long-term effects of stress and KORs in females. We examined the long-term effects of social defeat stress on the aversive properties of KOR activation in male and female California mice (Peromyscus californicus) using a conditioned place aversion paradigm. Female California mice naïve to social defeat, formed a place aversion following treatment with 2...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28615948/marijuana-use-recent-marijuana-initiation-and-progression-to-marijuana-use-disorder-among-young-male-and-female-adolescents-aged-12-14-living-in-us-households
#2
Valerie L Forman-Hoffman, Cristie Glasheen, Kathryn R Batts
Marijuana initiation during adolescence, and early adolescence in particular, is associated with adverse health consequences. Our study used 2005-2014 data from the annual, cross-sectional National Survey on Drug Use and Health to study the prevalence and correlates of marijuana initiation, use, and marijuana use disorder (MUD; abuse or dependence) among 12- to 14-year olds living in civilian US households (n = 84 954). Examined correlates included age, sex, race/ethnicity, poverty status, metropolitan status, year of survey, depression, tobacco use, alcohol use, and fighting at school...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28614083/pain-catastrophizing-moderates-relationships-between-pain-intensity-and-opioid-prescription-nonlinear-sex-differences-revealed-using-a-learning-health-system
#3
Yasamin Sharifzadeh, Ming-Chih Kao, John A Sturgeon, Thomas J Rico, Sean Mackey, Beth D Darnall
BACKGROUND: Pain catastrophizing is a maladaptive response to pain that amplifies chronic pain intensity and distress. Few studies have examined how pain catastrophizing relates to opioid prescription in outpatients with chronic pain. METHODS: The authors conducted a retrospective observational study of the relationships between opioid prescription, pain intensity, and pain catastrophizing in 1,794 adults (1,129 women; 63%) presenting for new evaluation at a large tertiary care pain treatment center...
July 2017: Anesthesiology
https://www.readbyqxmd.com/read/28608287/increased-glutamic-acid-decarboxylase-expression-in-the-hypothalamic-suprachiasmatic-nucleus-in-depression
#4
Xueyan Wu, Rawien Balesar, Jing Lu, Sahar Farajnia, Qiongbin Zhu, Manli Huang, Ai-Min Bao
In depression, disrupted circadian rhythms reflect abnormalities in the central circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN). Although many SCN neurons are said to be GABAergic, it was not yet known whether and how SCN GABA changes occur in the SCN in depression. We, therefore, studied GABA in the SCN in relation to the changes in arginine vasopressin (AVP), which is one of the major SCN output systems. Postmortem hypothalamus specimens of 13 subjects suffering from depression and of 13 well-matched controls were collected...
June 12, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28591782/sex-dependent-effects-of-stress-on-immobility-behavior-and-vta-dopamine-neuron-activity-modulation-by-ketamine
#5
Millie Rincón-Cortés, Anthony A Grace
Background: Stress constitutes a risk factor across several psychiatric disorders. Moreover, females are more susceptible to stress-related disorders, such as depression, than males. Although dopamine (DA) system underactivation is implicated in the pathophysiology of depression, little is known about the female DA system at baseline and post-stress. Methods: The effects of chronic mild stress (CMS) were examined on ventral tegmental area (VTA) DA neuron activity and forced swim test (FST) immobility by comparing male and female rats...
June 7, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28588958/women-s-health-a-new-global-agenda
#6
Sanne A E Peters, Mark Woodward, Vivekanand Jha, Stephen Kennedy, Robyn Norton
Global efforts to improve the health of women largely focus on improving sexual and reproductive health. However, the global burden of disease has changed significantly over the past decades. Currently, the greatest burden of death and disability among women is attributable to non-communicable diseases (NCDs), most notably cardiovascular diseases, cancers, respiratory diseases, diabetes, dementia, depression and musculoskeletal disorders. Hence, to improve the health of women most efficiently, adequate resources need to be allocated to the prevention, management and treatment of NCDs in women...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28588517/sleep-affect-and-social-competence-from-preschool-to-preadolescence-distinct-pathways-to-emotional-and-social-adjustment-for-boys-and-for-girls
#7
Joan E Foley, Marsha Weinraub
Using a normative sample of 1,057 children studied across 4 waves over 6 years with multiple informants, we investigated transactional relations for sleep problems, anxious-depressed symptoms, and social functioning from preschool to preadolescence, assessing cumulative effects on children's emotional and social adjustment. To examine sex differences in the developmental processes, we conducted separate analyses for boys and girls. For both boys and girls, longitudinal cross-lagged panel analyses showed that preschool sleep problems directly predicted anxious-depressed symptoms 2 years later; indirect effects continued into preadolescence...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28585019/women-in-the-midluteal-phase-of-the-menstrual-cycle-have-difficulty-suppressing-the-processing-of-negative-emotional-stimuli-an-event-related-potential-study
#8
Bethany R Lusk, Andrea R Carr, Valerie A Ranson, Kim L Felmingham
Emotion regulation deficits have been implicated in anxiety and depressive disorders, and these internalising disorders are more prevalent in women than men. Few electrophysiological studies have investigated sex differences in emotional reactivity and emotion regulation controlling for menstrual phase. Event-related potentials (ERPs) were recorded from 28 early follicular women, 29 midluteal women, and 27 men who completed an emotion regulation task. A novel finding of increased N2 amplitude during suppression was found for midluteal women compared with men...
June 5, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28584860/integrative-analysis-of-sex-differences-in-the-rapid-antidepressant-effects-of-ketamine-in-preclinical-models-for-individualized-clinical-outcomes
#9
Samantha K Saland, Florian Duclot, Mohamed Kabbaj
In major depressive disorder, women exhibit higher lifetime prevalence and different antidepressant response rates than men, which illustrates the importance of examining individual differences in the pathophysiology of depression and therapeutic response. In recent years, the consideration of sex in related preclinical research has thus gained interest-particularly in light of novel evidence for rapid-acting antidepressants. Notably, the literature recently revealed a higher sensitivity of females to the antidepressant effects of the N-methyl-D-aspartate receptor antagonist ketamine, in both baseline and preclinical conditions...
April 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28580124/sex-dependent-effects-of-maternal-corticosterone-and-ssri-treatment-on-hippocampal-neurogenesis-across-development
#10
Aarthi R Gobinath, Joanna L Workman, Carmen Chow, Stephanie E Lieblich, Liisa A M Galea
BACKGROUND: Postpartum depression affects approximately 15% of mothers and represents a form of early life adversity for developing offspring. Postpartum depression can be treated with prescription antidepressants like fluoxetine (FLX). However, FLX can remain active in breast milk, raising concerns about the consequences of neonatal FLX exposure. The hippocampus is highly sensitive to developmental stress, and males and females respond differently to stress at many endpoints, including hippocampal plasticity...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28576898/sex-differences-in-auditory-verbal-hallucinations-in-early-middle-and-late-adolescence-results-from-a-survey-of-17-451-japanese-students-aged-12-18-years
#11
Yoko Morokuma, Kaori Endo, Atushi Nishida, Syudo Yamasaki, Shuntaro Ando, Yuko Morimoto, Miharu Nakanishi, Yuji Okazaki, Toshi A Furukawa, Shigeru Morinobu, Shinji Shimodera
OBJECTIVES: Women have higher rates of auditory verbal hallucinations (AVH) than men; however, less is known about sex differences in the prevalence of AVH in early, middle and late adolescence. We sought to elucidate the differences in the prevalence of AVH and to examine the degree to which these differences could be explained by differences in levels of depressive symptoms. DESIGN: We used a cross-sectional design and a self-reported questionnaire. SETTING: Participants were recruited from public junior and senior high schools in Tsu, Mie Prefecture and Kochi Prefecture, Japan...
June 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28559571/sex-differences-in-the-clinical-characteristics-and-brain-gray-matter-volume-alterations-in-unmedicated-patients-with-major-depressive-disorder
#12
Xiao Yang, Zugui Peng, Xiaojuan Ma, Yajing Meng, Mingli Li, Jian Zhang, Xiuliu Song, Ye Liu, Huanhuan Fan, Liansheng Zhao, Wei Deng, Tao Li, Xiaohong Ma
This study was to explore the sex differences in clinical characteristics and brain gray matter volume (GMV) alterations in 29 male patients with major depressive disorder (MDDm), 53 female patients with MDD (MDDf), and in 29 male and 53 female matched healthy controls. Maps of GMV were constructed using magnetic resonance imaging data and compared between groups. We evaluated clinical symptoms using the Hamilton Rating Scale for Depression and obtained a total score and five syndrome scores. A two-factor ANCOVA model was specified using SPM8, with sex and diagnosis as the between-subject factors...
May 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28556831/sex-differences-in-recent-first-onset-depression-in-an-epidemiological-sample-of-adolescents
#13
J Breslau, S E Gilman, B D Stein, T Ruder, T Gmelin, E Miller
Prior studies provide limited and contradictory evidence regarding sex differences in the incidence of depression during adolescence, a critical period for development of the disorder. Data from six consecutive years (2009-2014) of a national survey of US adolescents aged 12-17 (N=101 685) are used to characterize sex differences in the incidence of depression by age and to compare recent first-onset and persistent depression with respect to impairment, suicide attempts, conduct problems and academic functioning...
May 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28546280/absolute-values-of-lung-function-explain-the-sex-difference-in-breathlessness-in-the-general-population
#14
Magnus Ekström, Linus Schiöler, Rune Grønseth, Ane Johannessen, Cecilie Svanes, Benedicte Leynaert, Deborah Jarvis, Thorarinn Gislason, Pascal Demoly, Nicole Probst-Hensch, Isabelle Pin, Angelo G Corsico, Bertil Forsberg, Joachim Heinrich, Dennis Nowak, Chantal Raherison-Semjen, Shyamali C Dharmage, Giulia Trucco, Isabel Urrutia, Jesús Martinez-Moratalla Rovira, José Luis Sánchez-Ramos, Christer Janson, Kjell Torén
Activity-related breathlessness is twice as common among females as males in the general population and is associated with adverse health outcomes. We tested whether this sex difference is explained by the lower absolute forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) in females.This was a cross-sectional analysis of 3250 subjects (51% female) aged 38-67 years across 13 countries in the population-based third European Community Respiratory Health Survey. Activity-related breathlessness was measured using the modified Medical Research Council (mMRC) scale...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28541768/sex-differences-in-the-presentation-of-body-dysmorphic-disorder-in-a-community-sample-of-adolescents
#15
Sophie C Schneider, Jonathan Mond, Cynthia M Turner, Jennifer L Hudson
The current study sought to explore sex differences in the presentation of probable full-syndrome and subthreshold body dysmorphic disorder (BDD) in adolescents from an Australian community sample. Specifically, it examined sex differences in the types of BDD symptoms endorsed, body areas of concern, and the association with elevated symptoms of comorbid disorders. In male participants, it also compared the presenting features of those with and without muscle dysmorphia. Of 3,149 adolescents assessed using self-report questionnaires, 162 (5...
May 25, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28527954/sex-differences-in-the-effect-of-chronic-mild-stress-on-mouse-prefrontal-cortical-bdnf-levels-a-role-of-major-ovarian-hormones
#16
Bhanu Chandra Karisetty, Pranav Chintamani Joshi, Arvind Kumar, Sumana Chakravarty
Depression induced by stress is affected by sex, age and hormonal status of the animal and also by duration and type of the stressors. Moreover, higher prevalence of depression and comorbidities in women than men implies the need to include the sex variable in studies on animal models of depression. The present study was therefore initiated to evaluate the effect of sex and ovarian hormones on depression-like phenotypes in mice exposed to a 21-day Chronic Variable Mild Stress (CVMS) paradigm. Adult male, intact female and, ovariectomized (OVX) female mice exposed to CVMS displayed despair behavior, a depression-like phenotype, in all the groups...
May 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28521620/depression-inflammation-and-physiological-risk-in-late-life-a-national-longitudinal-study
#17
Aniruddha Das
This nationally representative study queried effects of community dwelling older adults' depression and inflammation at baseline on over-time changes in surrogate markers of their cardiometabolic risk. Data were from the 2005-2006 and 2010-2011 waves of the U.S. National Social Life, Health, and Aging Project. Inflammation was indicated by C-reactive protein and depression by the CES-D scale. Cardiometabolic markers included hemoglobin A1c and systolic BP. Lagged dependent variable models were used to examine effects...
2017: Biodemography and Social Biology
https://www.readbyqxmd.com/read/28502781/checks-and-balances-the-glucocorticoid-receptor-and-nf%C3%A4-b-in-good-times-and-bad
#18
REVIEW
Mandakh Bekhbat, Sydney A Rowson, Gretchen N Neigh
Mutual regulation and balance between the endocrine and immune systems facilitate an organism's stress response and are impaired following chronic stress or prolonged immune activation. Concurrent alterations in stress physiology and immunity are increasingly recognized as contributing factors to several stress-linked neuropsychiatric disorders including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) - effectors of the stress and immune axes, respectively - may play a key role in mediating the harmful effects of chronic stress on mood and behavior...
May 11, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28498792/sex-differences-in-1-year-outcomes-after-percutaneous-coronary-intervention-in-the-veterans-health-administration
#19
Melissa M Farmer, Maggie A Stanislawski, Mary E Plomondon, Bevanne Bean-Mayberry, Nataria T Joseph, Lauren E Thompson, Jessica L Zuchowski, Stacie L Daugherty, Elizabeth M Yano, P Michael Ho
BACKGROUND: Advancements in percutaneous coronary intervention (PCI) for treating obstructive coronary artery disease have reduced major adverse events, including mortality. Yet, evidence as to whether women and men experience similar outcomes is mixed. The objective was to examine sex differences in 1-year major adverse cardiac outcomes for the national population of patients undergoing PCI at Veterans Health Administration (VA) cardiac catheterization laboratories. METHODS: All Veterans undergoing PCI at VA hospitals between October 1, 2007 and September 30, 2013 (N = 64,757; Women = 1,040) were included...
May 12, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28465602/body-mass-index-and-depressive-symptoms-in-adolescents-in-taiwan-testing-mediation-effects-of-peer-victimization-and-sleep-problems
#20
L-Y Chang, H-Y Chang, W-C Wu, L N Lin, C-C Wu, L-L Yen
BACKGROUND: Despite recognition of the link between body mass index (BMI) and depression in adolescence, the underlying mechanisms behind this association remain understudied. This study aims to examine three mediational pathways from BMI to depressive symptoms through peer victimization and sleep problems. Sex differences in the mediating effects were also explored. METHODS: Data came from 1893 adolescents participating in a multi-wave longitudinal study from grade 9 to 12 in northern Taiwan were analyzed...
May 3, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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