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https://www.readbyqxmd.com/read/28818810/evaluating-quality-of-life-in-epilepsy-the-role-of-screening-for-adverse-drug-effects-depression-and-anxiety
#1
Jean-Arthur Micoulaud-Franchi, Fabrice Bartolomei, Roderick Duncan, Aileen McGonigal
OBJECTIVE: The objective of this study was to evaluate the contribution of validated screening tools for antiepileptic drug (AED) adverse effects, depression, and anxiety to measure the quality of life (QoL) in people with epilepsy (PWE). METHODS: Patients in a tertiary epilepsy service were screened for quality of life (using QOLIE-31), major depressive disorder (MDD) (NDDI-E), generalized anxiety disorder (GAD) (GAD-7), and AED effects (AEP). Mini International Neuropsychiatric Interview (MINI) generalized anxiety disorder module was also performed...
August 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28789949/reduced-hippocampal-il-10-expression-altered-monoaminergic-activity-and-anxiety-and-depressive-like-behavior-in-female-mice-subjected-to-chronic-social-instability-stress
#2
Ainitze Labaka, Eneritz Gómez-Lázaro, Oscar Vegas, Joana Pérez-Tejada, Amaia Arregi, Larraitz Garmendia
Evidence indicates that release of pro-inflammatory cytokines induced by social stress contributes to affective disorders. Additionally, there are known sex differences in both the stress response and the stressors that can elicit this response. In this regard, the chronic social instability (CSI) rodent model of stress appears to be the best fit for the social nature of females. This study analyzed the effects of CSI on female mouse behavior, hippocampal cytokine expression, tryptophan metabolism and monoaminergic activity...
August 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28771498/autonomy-connectedness-mediates-sex-differences-in-symptoms-of-psychopathology
#3
Marrie H J Bekker, Marcel A L M van Assen
OBJECTIVES: This study aimed to examine if autonomy-connectedness, capacity for self-governance under the condition of connectedness, would mediate sex differences in symptoms of various mental disorders (depression, anxiety, eating disorders, antisocial personality disorder). METHOD: Participants (N = 5,525) from a representative community sample in the Netherlands filled out questionnaires regarding the variables under study. RESULTS: Autonomy-connectedness (self-awareness, SA; sensitivity to others, SO; capacity for managing new situations, CMNS) fully mediated the sex differences in depression and anxiety, and partly in eating disorder -(drive for thinness, bulimia, and body dissatisfaction) and anti-social personality disorder characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28760765/high-sex-ratios-in-rural-china-declining-well-being-with-age-in-never-married-men
#4
Xudong Zhou, Therese Hesketh
In parts of rural China male-biased sex ratios at birth, combined with out-migration of women, have led to highly male-biased adult sex ratios, resulting in large numbers of men being unable to marry, in a culture where marriage and reproduction are an expectation. The aim of this study was to test the hypotheses that older unmarried men are more predisposed to depression, low self-esteem and aggression than both those who are married, and those who are younger and unmarried. Self-completion questionnaires were administered among men aged 20-40 in 48 villages in rural Guizhou province, southwestern China...
September 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28759308/vasopressin-deletion-is-associated-with-sex-specific-shifts-in-the-gut-microbiome
#5
Christopher T Fields, Benoit Chassaing, Matthew J Paul, Andrew T Gewirtz, Geert J de Vries
Brattleboro rats harbor a spontaneous deletion of the arginine-vasopressin (Avp) gene. In addition to diabetes insipidus, these rats exhibit low levels of anxiety and depressive behaviors. Recent work on the gut-brain axis has revealed that gut microbiota can influence anxiety behaviors. Therefore, we studied the effects of Avp gene deletion on gut microbiota. Since Avp gene expression is sexually different, we also examined how Avp deletion affects sex differences in gut microbiota. Males and females show modest but differentiated shifts in taxa abundance across 3 separate Avp deletion genotypes: wildtype (WT), heterozygous (Het) and AVP-deficient Brattleboro (KO) rats...
July 31, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28756082/asthma-morbidity-comorbidities-and-modifiable-factors-among-older-adults
#6
Joy Hsu, Jessica Chen, Maria C Mirabelli
BACKGROUND: Asthma morbidity is increased among older adults, especially older adult women. Interventions to improve asthma control in this population are not well described. OBJECTIVE: The objective of this study was to identify risk factors (including modifiable factors) associated with asthma-related hospitalizations and emergency department or urgent care center visits (ED/UCV) among older adults. A secondary objective was to investigate sex differences in variables relevant to asthma control...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28754386/sex-specific-differences-in-the-association-between-childhood-adversity-and-cardiovascular-disease-in-adulthood-evidence-from-a-national-cohort-study
#7
Yasmin Garad, Katerina Maximova, Nathalie MacKinnon, Jennifer J McGrath, Anita L Kozyrskyj, Ian Colman
BACKGROUND: Childhood adversity increases the risk for cardiovascular disease (CVD) in adulthood. Previously proposed mechanisms suggest that the association is mediated by stress reactivity-known to be higher in women-and is aggravated by adult stress, but this has not yet been confirmed. Therefore, we investigated sex differences to better understand possible pathways from childhood adversity to CVD. METHODS: The National Population Health Survey, a 15-year cohort study of Canadians aged 18-49 years at baseline was used...
August 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28744228/adolescent-major-depressive-disorder-neuroimaging-evidence-of-sex-difference-during-an-affective-go-no-go-task
#8
Jie-Yu Chuang, Cindy C Hagan, Graham K Murray, Julia M E Graham, Cinly Ooi, Roger Tait, Rosemary J Holt, Rebecca Elliott, Adrienne O van Nieuwenhuizen, Edward T Bullmore, Belinda R Lennox, Barbara J Sahakian, Ian M Goodyer, John Suckling
Compared to female major depressive disorder (MDD), male MDD often receives less attention. However, research is warranted since there are significant sex differences in the clinical presentation of MDD and a higher rate of suicide in depressed men. To the best of our knowledge, this is the first functional magnetic resonance imaging (fMRI) study with a large sample addressing putative sex differences in MDD during adolescence, a period when one of the most robust findings in psychiatric epidemiology emerges; that females are twice as likely to suffer from MDD than males...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28735700/sex-differences-in-the-relationship-between-conduct-disorder-and-cortical-structure-in%C3%A2-adolescents
#9
Areti Smaragdi, Harriet Cornwell, Nicola Toschi, Roberta Riccelli, Karen Gonzalez-Madruga, Amy Wells, Roberta Clanton, Rosalind Baker, Jack Rogers, Nayra Martin-Key, Ignazio Puzzo, Molly Batchelor, Justina Sidlauskaite, Anka Bernhard, Anne Martinelli, Gregor Kohls, Kerstin Konrad, Sarah Baumann, Nora Raschle, Christina Stadler, Christine Freitag, Edmund J S Sonuga-Barke, Stephane De Brito, Graeme Fairchild
OBJECTIVE: Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such sex differences extend to cortical and subcortical structure. METHOD: As part of a European multisite study (FemNAT-CD), structural magnetic resonance imaging (MRI) data were collected from 48 female and 48 male participants with CD and from 104 sex-, age-, and pubertal-status-matched controls (14-18 years of age)...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28712429/the-association-between-multiple-chemical-sensitivity-and-mental-illness-evidence-from-a-nationally-representative-sample-of-canadians
#10
Dylan Johnson, Ian Colman
OBJECTIVE: The goal of the present study was to investigate the association between multiple chemical sensitivity (MCS) and major depressive disorder (MDD), generalized anxiety disorder (GAD), MDD and GAD comorbidity (MDD+GAD), severe distress, and positive mental wellbeing. METHODS: This cross-sectional investigation was carried out using the 2012 Canadian Community Health Survey - Mental Health Component. The study population consisted of 21,977 individuals aged 20 and older, from Canada's ten provinces...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28708121/sex-differences-in-the-relationship-between-sleep-behavior-fish-consumption-and-depressive-symptoms-in-the-general-population-of-south-korea
#11
Atin Supartini, Taro Oishi, Nobuyuki Yagi
Sleep, fish consumption, and depression have a close relationship; however, the role of sex differences in sleep, fish consumption, and depression research is not yet well-established. This study aimed to examine whether the impact of bedtime, sleep-onset latency, sleep duration, sleep quality, and fish consumption on depressive symptoms differed in women and men. An online survey was conducted in South Korea with a stratified random sample of 600 participants between the ages of 20 and 69, whose gender and age were proportional to estimates of Korea's general population...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28695280/effect-of-post-weaning-isolation-on-anxiety-and-depressive-like-behaviors-of-c57bl-6j-mice
#12
Qian Huang, Ying Zhou, Lin-Yun Liu
Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field...
July 10, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28694824/burden-and-correlates-of-falls-among-rural-elders-of-south-india-mobility-and-independent-living-in-elders-study
#13
Pawan Kumar Sharma, Clareann H Bunker, Tushar Singh, Enakshi Ganguly, P Sudhakar Reddy, Anne B Newman, Jane A Cauley
AIM: Falls are an important contributor to loss of function, morbidity, and mortality in elders. Little is known about falls in Indian populations. The objective of this cross-sectional report was to identify the prevalence and correlates of falls in a cohort of 562 rural southern Indian men and women. METHODS: Risk factors included demographics, anthropometrics, self-reported health, medical history, physical function, vision, depression, and lifestyle. Odds ratios were calculated using logistic regression...
2017: Current Gerontology and Geriatrics Research
https://www.readbyqxmd.com/read/28678409/exposure-to-chronic-variable-social-stress-during-adolescence-alters-affect-related-behaviors-and-adrenocortical-activity-in-adult-male-and-female-inbred-mice
#14
Michael J Caruso, Helen M Kamens, Sonia A Cavigelli
Rodent models provide valuable insight into mechanisms that underlie vulnerability to adverse effects of early-life challenges. Few studies have evaluated sex differences in anxiogenic or depressogenic effects of adolescent social stress in a rodent model. Furthermore, adolescent stress studies often use genetically heterogeneous outbred rodents which can lead to variable results. The current study evaluated the effects of adolescent social stress in male and female inbred (BALB/cJ) mice. Adolescent mice were exposed to repeat cycles of alternating social isolation and social novelty for 4 weeks...
July 5, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28670290/sex-differences-in-the-peripheral-immune-system-in-patients-with-depression
#15
Badari Birur, Ellen M Amrock, Richard C Shelton, Li Li
BACKGROUND: Females are twice as likely as males to experience depression. Recent findings indicate a relationship linking inflammation with depression. Whether the higher prevalence of depression in women is sex-specific or if inflammation contributes to a higher prevalence of depression in females is unclear. Thus, the objective was to determine whether depressed females show higher inflammation compared to males in a cross-sectional study. MATERIALS AND METHODS: Two hundred participants were enrolled...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28668344/maternal-thyroid-hormone-trajectories-during-pregnancy-and-child-behavioral-problems
#16
Joyce J Endendijk, Hennie A A Wijnen, Victor J M Pop, Anneloes L van Baar
There is ample evidence demonstrating the importance of maternal thyroid hormones, assessed at single trimesters in pregnancy, for child cognition. Less is known, however, about the course of maternal thyroid hormone concentrations during pregnancy in relation to child behavioral development. Child sex might be an important moderator, because there are sex differences in externalizing and internalizing behavioral problems. The current study examined the associations between maternal thyroid hormone trajectories versus thyroid assessments at separate trimesters of pregnancy and child behavioral problems, as well as sex differences in these associations...
July 11, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28655362/measuring-depressive-symptoms-during-adolescence-what-is-the-role-of-gender
#17
C Bulhões, E Ramos, M Severo, S Dias, H Barros
AIMS: The higher prevalence of depressive symptoms among females is well recognised but the reasons for this gender difference are not fully understood. There is growing evidence that current diagnostic criteria and instruments used to assess depression are less sensitive to depression in men, but studies about this issue among adolescents are scarce, especially in Latin countries. Our aim was to assess sex differences in the intensity of depressive symptoms, measured using the Beck Depression Inventory second edition (BDI-II), among Portuguese adolescents, at 13 and 17 years of age...
June 28, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28625549/the-long-term-effects-of-stress-and-kappa-opioid-receptor-activation-on-conditioned-place-aversion-in-male-and-female-california-mice
#18
Abigail R Laman-Maharg, Tiffany Copeland, Evelyn Ordoñes Sanchez, Katharine L Campi, Brian C Trainor
Psychosocial stress leads to the activation of kappa opioid receptors (KORs), which induce dysphoria and facilitate depression-like behaviors. However, less is known about the long-term effects of stress and KORs in females. We examined the long-term effects of social defeat stress on the aversive properties of KOR activation in male and female California mice (Peromyscus californicus) using a conditioned place aversion paradigm. Female California mice naïve to social defeat, formed a place aversion following treatment with 2...
August 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28615948/marijuana-use-recent-marijuana-initiation-and-progression-to-marijuana-use-disorder-among-young-male-and-female-adolescents-aged-12-14-living-in-us-households
#19
Valerie L Forman-Hoffman, Cristie Glasheen, Kathryn R Batts
Marijuana initiation during adolescence, and early adolescence in particular, is associated with adverse health consequences. Our study used 2005-2014 data from the annual, cross-sectional National Survey on Drug Use and Health to study the prevalence and correlates of marijuana initiation, use, and marijuana use disorder (MUD; abuse or dependence) among 12- to 14-year olds living in civilian US households (n = 84 954). Examined correlates included age, sex, race/ethnicity, poverty status, metropolitan status, year of survey, depression, tobacco use, alcohol use, and fighting at school...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28614083/pain-catastrophizing-moderates-relationships-between-pain-intensity-and-opioid-prescription-nonlinear-sex-differences-revealed-using-a-learning-health-system
#20
Yasamin Sharifzadeh, Ming-Chih Kao, John A Sturgeon, Thomas J Rico, Sean Mackey, Beth D Darnall
BACKGROUND: Pain catastrophizing is a maladaptive response to pain that amplifies chronic pain intensity and distress. Few studies have examined how pain catastrophizing relates to opioid prescription in outpatients with chronic pain. METHODS: The authors conducted a retrospective observational study of the relationships between opioid prescription, pain intensity, and pain catastrophizing in 1,794 adults (1,129 women; 63%) presenting for new evaluation at a large tertiary care pain treatment center...
July 2017: Anesthesiology
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