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pediatric acid reflux

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https://www.readbyqxmd.com/read/27823773/surgical-management-of-gastroesophageal-reflux-disease-gerd-in-children-a-systematic-review
#1
Tim Jancelewicz, Monica E Lopez, Cynthia D Downard, Saleem Islam, Robert Baird, Shawn J Rangel, Regan F Williams, Meghan A Arnold, Dave Lal, Elizabeth Renaud, Julia Grabowski, Roshni Dasgupta, Mary Austin, Julia Shelton, Danielle Cameron, Adam B Goldin
OBJECTIVE: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to derive recommendations from the medical literature regarding the surgical treatment of pediatric gastroesophageal reflux disease (GERD). METHODS: Five questions were addressed by searching the MEDLINE, Cochrane, Embase, Central, and National Guideline Clearinghouse databases using relevant search terms. Consensus recommendations were derived for each question based on the best available evidence...
October 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27736035/role-of-non-acid-gastro-esophageal-reflux-in-children-with-respiratory-symptoms
#2
Letizia Zenzeri, Paolo Quitadamo, Renato Tambucci, Dario Ummarino, Antonio Poziello, Erasmo Miele, Annamaria Staiano
OBJECTIVES: Respiratory symptoms are a possible atypical clinical picture of gastro-esophageal reflux disease (GERD). However, a significant number of patients with GERD-related respiratory symptoms do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. The aim of our study is to assess the pH-impedance features of GER inducing airway symptoms, compared with GER inducing typical gastro-intestinal (GI) symptoms...
October 13, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27671545/alginate-therapy-is-effective-treatment-for-gastroesophageal-reflux-disease-symptoms-a-systematic-review-and-meta-analysis
#3
D A Leiman, B P Riff, S Morgan, D C Metz, G W Falk, B French, C A Umscheid, J D Lewis
In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective. However, in some patients, especially those with non-erosive reflux disease or atypical GERD symptoms, acid suppressive therapy with PPIs is not as successful. Alginates are medications that work through an alternative mechanism by displacing the post-prandial gastric acid pocket. We performed a systematic review and meta-analysis to examine the benefit of alginate-containing compounds in the treatment of patients with symptoms of GERD...
September 26, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27543119/computing-quantitative-indicators-of-structural-renal-damage-in-pediatric-dmsa-scans
#4
F Sampedro, A Domenech, S Escalera, I Carrio
OBJECTIVES: The proposal and implementation of a computational framework for the quantification of structural renal damage from (99m)Tc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independent manner. MATERIALS AND METHODS: From a set of 16 pediatric DMSA-positive scans and 16 matched controls and using both expert-guided and automatic approaches, a set of image-derived quantitative indicators was computed based on the relative size, intensity and histogram distribution of the lesion...
August 16, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27493880/barriers-to-drug-adherence-in-the-treatment-of-urea-cycle-disorders-assessment-of-patient-caregiver-and-provider-perspectives
#5
Oleg A Shchelochkov, Klara Dickinson, Bruce F Scharschmidt, Brendan Lee, Miguel Marino, Cynthia Le Mons
UNLABELLED: Patients and families living with metabolic disorders face challenging dietary and drug treatment regimens. On the hypothesis that poor palatability, volume and frequency of drug/formula administration contribute to treatment non-adherence and hyperammonemic episodes, a survey was conducted of patient, caregiver (CG) and physician perspectives on treatments used in urea cycle disorders (UCD). METHODS: A paper and online survey assessed experience with UCD medications, medical foods and dietary supplements...
September 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27455161/early-antibiotic-treatment-for-pediatric-febrile-urinary-tract-infection-and-renal-scarring
#6
Nader Shaikh, Tej K Mattoo, Ron Keren, Anastasia Ivanova, Gang Cui, Marva Moxey-Mims, Massoud Majd, Harvey A Ziessman, Alejandro Hoberman
IMPORTANCE: Existing data regarding the association between delayed initiation of antimicrobial therapy and the development of renal scarring are inconsistent. OBJECTIVE: To determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections (UTIs) is associated with the occurrence and severity of renal scarring. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study that combined data from 2 previously conducted longitudinal studies (the Randomized Intervention for Children With Vesicoureteral Reflux trial and the Careful Urinary Tract Infection Evaluation Study)...
September 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27438415/combined-24-hours-esophageal-ph-monitoring-and-multichannel-intraluminal-impedance-for-comparison-of-gastroesophageal-reflux-in-children-with-typical-versus-atypical-symptoms-of-gastroesophageal-reflux-disease
#7
Seyed Mohsen Dehghani, Seyed Alireza Taghavi, Hazhir Javaherizadeh, Maryam Nasri
BACKGROUND: - Gastroesophageal reflux disease is the most common esophageal disorder in pediatrics. OBJECTIVE: - The aim of this study was to compare reflux parameters of typical and atypical symptoms of gastroesophageal reflux disease using 24-hour esophageal pH monitoring and multichannel intraluminal impedance in pediatric population. METHODS: - In this prospective study, 43 patients aged less than 18 year with suspected gastroesophageal reflux disease were enrolled...
July 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27412739/-clinical-analysis-of-enteral-nutrition-in-47-children
#8
R D Zhuang, L J Tang, Y H Fang, K R Peng, J Chen
OBJECTIVE: To explore the efficacy and safety of the application of enteral nutrition (EN) in gastrointestinal disease in children, and to explore the possibility of the implementation of family EN. METHOD: Retrospective analysis of disease spectrum, EN approach, preparation, speed and time as well as adverse reactions and outcomes in 47 pediatric patients with gastrointestinal disease underwent EN therapy during July 2014 to March 2015. The nutrition indicators before and after EN therapy were compared by paired t-test...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27369283/effects-and-efficacy-of-laparoscopic-fundoplication-in-children-with-gerd-a-prospective-multicenter-study
#9
Femke A Mauritz, J M Conchillo, L W E van Heurn, P D Siersema, C E J Sloots, R H J Houwen, D C van der Zee, M Y A van Herwaarden-Lindeboom
INTRODUCTION: Laparoscopic antireflux surgery (LARS) in children primarily aims to decrease reflux events and reduce reflux symptoms in children with therapy-resistant gastroesophageal reflux disease (GERD). The aim was to objectively assess the effect and efficacy of LARS in pediatric GERD patients and to identify parameters associated with failure of LARS. METHODS: Twenty-five children with GERD [12 males, median age 6 (2-18) years] were included prospectively...
July 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27368473/helicobacter-pylori-seroprevalence-in-children-with-sleep-disordered-breathing
#10
J Wasilewska, M Klukowski, K Debkowska, J Kilon, D Citko, M Flisiak, M Oleksinska, M Kaczmarski
OBJECTIVE: Chronic Helicobacter pylori (HP) infection is considered to be a factor involved in obstructive sleep apnea syndrome (OSAS). This cross-sectional study examined the seroprevalence of HP in children with sleep-disordered breathing (SDB) in respect to OSAS severity and in reference to other common pediatric medical conditions. METHODS: Overnight polysomnography with pH-metry (PSG) was performed at a Sleep Laboratory (in the years 2008-2011). OSAS severity was determined based on Obstructive Apnea Index (OAI)...
August 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27363638/cost-and-radiation-exposure-in-the-workup-of-febrile-pediatric-urinary-tract-infections
#11
Jason E Michaud, Natasha Gupta, Timothy S Baumgartner, Brian Kim, Thangamadhan Bosemani, Ming-Hsien Wang
BACKGROUND: Technetium-99m dimercaptosuccinic acid (DMSA) scans are often used in the evaluation of pediatric patients with febrile urinary tract infections (UTIs). Given the prevalence of febrile UTIs, we sought to quantify the cost, radiation exposure, and clinical utility of DMSA scans when compared with dedicated pediatric renal ultrasounds (RUSs). MATERIALS AND METHODS: An institutional review board approved retrospective study of children under the age of 18 years evaluated at our institution for febrile UTIs between the years 2004-2013 was conducted...
June 15, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27310222/airway-reflux
#12
Nikki Johnston, Frank Ondrey, Rachel Rosen, Bryan P Hurley, Jon Gould, Jacquie Allen, John DelGaudio, Kenneth W Altman
An ever-increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and complicated aspect of medicine that requires a multidisciplinary approach. Evidence indicates that it is not only the acidic components of gastric refluxate that injure extraesophageal tissues but also the nonacidic components, such as pepsin and bile. There is a realization that proton pump inhibitors will not be effective when nonacidic components of refluxate are causing the problem...
June 16, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27193974/laryngopharyngeal-reflux-in-children-with-chronic-otitis-media-with-effusion
#13
Anna Górecka-Tuteja, Izabela Jastrzębska, Jacek Składzień, Krzysztof Fyderek
BACKGROUND/AIMS: To evaluate the characteristic properties of laryngopharyngeal reflux (LPR) and gastroesophageal reflux (GER) in children with otitis media with effusion (OME) using 24-hour multichannel intraluminal impedance combined with dual-probe (pharyngeal and esophageal) pH-metry. METHODS: Children aged 7-10 years of age with OME underwent 24-hour multichannel intraluminal impedance pH-metry. The upper pH sensor was situated 1 cm above the upper esophageal sphincter, and the lower pH sensor was placed 3-5 cm above the lower esophageal sphincter...
July 30, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/27186221/usefulness-of-neutrophil-lymphocyte-ratio-in-young-children-with-febrile-urinary-tract-infection
#14
Song Yi Han, I Re Lee, Se Jin Park, Ji Hong Kim, Jae Il Shin
PURPOSE: Acute pyelonephritis (APN) is a serious bacterial infection that can cause renal scarring in children. Early identification of APN is critical to improve treatment outcomes. The neutrophil-lymphocyte ratio (NLR) is a prognostic marker of many diseases, but it has not yet been established in urinary tract infection (UTI). The aim of this study was to determine whether NLR is a useful marker to predict APN or vesicoureteral reflux (VUR). METHODS: We retrospectively evaluated 298 pediatric patients (age≤36 months) with febrile UTI from January 2010 to December 2014...
March 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27151185/impact-of-laparoscopic-antireflux-surgery-on-belching-in-pediatric-gerd-patients
#15
N F Rinsma, F A Mauritz, L W E van Heurn, C E J Sloots, P D Siersema, R H J Houwen, D C van der Zee, A A M Masclee, J M Conchillo, M Y A Van Herwaarden-Lindeboom
BACKGROUND: Laparoscopic antireflux surgery (LARS) is a well-established treatment option for children with proton pomp inhibitor (PPI)-resistant gastroesophageal reflux disease (GERD). Besides preventing reflux of gastric fluid and solid content, LARS may also impair the ability of the stomach to vent intragastric air (i.e. gastric belching) and induce gas-related complications, such as bloating and/or hyperflatulence. Furthermore, it was previously hypothesized that LARS induces a behavioral type of belching, not originating from the stomach, called supragastric belching...
October 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27068927/gastroesophageal-reflux-disease-in-children-with-interstitial-lung-disease
#16
M A Dziekiewicz, K Karolewska-Bochenek, Ł Dembiński, A Gawronska, K Krenke, J Lange, M Banasiuk, E Kuchar, M Kulus, P Albrecht, A Banaszkiewicz
Gastroesophageal reflux disease is common in adult patients with interstitial lung disease. However, no data currently exist regarding the prevalence and characteristics of the disease in pediatric patients with interstitial lung disease. The aim of the present study was to prospectively assess the incidence of gastroesophageal reflux disease and characterize its features in children with interstitial lung disease. Gastroesophageal reflux disease was established based on 24 h pH-impedance monitoring (MII-pH)...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27068720/2015-david-y-graham-lecture-the-first-two-decades-of-eosinophilic-esophagitis-from-acid-reflux-to-food-allergy
#17
REVIEW
Ikuo Hirano
Collaborative efforts by pediatric and adult gastroenterologists, allergists, dieticians, and pathologists have brought about marked progress in the recognition, understanding, and management of eosinophilic esophagitis (EoE) over the past two decades. Once an esoteric diagnosis, EoE is now increasingly identified as a major cause of morbidity, afflicting both children and adults. The detection of mucosal eosinophils has evolved from a diagnostic feature of acid reflux to a biomarker of food sensitization of the esophagus...
June 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26906020/laparoscopic-nissen-fundoplication-mainly-reduces-the-volume-of-acid-reflux-and-potentially-improves-mucosal-integrity-up-to-the-middle-esophagus-in-neurologically-impaired-children-detected-by-esophageal-combined-ph-multichannel-intraluminal-impedance-measurements
#18
Suguru Fukahori, Minoru Yagi, Shinji Ishii, Kimio Asagiri, Nobuyuki Saikusa, Naoki Hashizume, Motomu Yoshida, Daisuke Masui, Saki Sakamoto, Shihori Tsuruhisa, Tomohiro Kurahachi, Yoshiaki Tanaka
BACKGROUND: The aim of this study was to evaluate detailed changes of gastroesophageal reflux disease (GERD) in children before and after laparoscopic Nissen fundoplication (LNF) utilizing esophageal combined pH-multichannel intraluminal impedance (pH/MII) measurements. PATIENTS AND METHODS: Thirteen patients with neurological impairment, who received laparoscopic Nissen fundoplication (LNF) owing to refractory pathological GERD, were enrolled in this study. 24h pH/MII was conducted in all patients before and one year after LNF...
August 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26439564/op-23-functional-dyspepsia-is-associated-with-duodenal-eosinophilia-in-a-pediatric-cohort
#19
L Wauters, S Nightingale, B Sulaiman, N Talley, M Walker
OBJECTIVES: Functional dyspepsia (FD) is a highly prevalent gastrointestinal disorder with unknown etiology. We aimed to assess the association between dyspeptic symptoms and duodenal eosinophilia in children referred for upper endoscopy. METHODS: In this retrospective cohort study, all histopathology reports of normal upper endoscopies performed at a single tertiary center between 2010 and 2014 were reviewed. FD was defined as epigastric pain or discomfort for more than 2 months with no response to acid suppressants...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26422097/esomeprazole-for-the-treatment-of-gerd-in-infants-ages-1-11-months
#20
RANDOMIZED CONTROLLED TRIAL
Harland Winter, Thirumazhisai Gunasekaran, Vasundhara Tolia, Frederic Gottrand, Peter N Barker, Marta Illueca
OBJECTIVES: Gastroesophageal reflux disease (GERD) is present in pediatric patients when reflux of gastric contents causes troublesome symptoms and/ or complications. The present study evaluates the efficacy and safety of esomeprazole in infants ages 1 to 11 months with GERD. METHODS: In this multicenter randomized, double-blind, placebo-controlled, parallel-group, treatment-withdrawal study, infants received open-label, weight-adjusted doses of esomeprazole (2...
July 2015: Journal of Pediatric Gastroenterology and Nutrition
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