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https://www.readbyqxmd.com/read/29782488/insight-into-small-molecule-binding-to-the-neonatal-fc-receptor-by-x-ray-crystallography-and-100-khz-magic-angle-spinning-nmr
#1
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 kHz after sedimentation, exploiting very fast spinning of the nondeuterated soluble 42 kDa receptor construct to obtain resolved proton-detected 2D and 3D NMR spectra. FcRn plays a crucial role in regulation of IgG and serum albumin catabolism. It is a clinically validated drug target for the treatment of autoimmune diseases caused by pathogenic antibodies via the inhibition of its interaction with IgG...
May 21, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29781256/improved-performance-in-mammalian-cell-perfusion-cultures-by-growth-inhibition
#2
Moritz K F Wolf, Aurélie Closet, Monika Bzowska, Jean-Marc Bielser, Jonathan Souquet, Hervé Broly, Massimo Morbidelli
Mammalian cell perfusion cultures represent a promising alternative for the production of various biopharmaceuticals to the current fed-batch technology. Long-term operation at a fixed viable cell density (VCD) requires a viable culture and a constant removal of excessive cells. Product loss in the cell removing bleed stream deteriorates the process yield. In this study, we investigated the use of chemical and environmental growth inhibition on culture performance by either adding valeric acid (VA) to the production media or by reducing the culture temperature (33...
May 21, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29777925/epidemiology-of-respiratory-pathogen-carriage-in-the-homeless-population-within-2-shelters-in-marseille-france-2015-2017-cross-sectional-one-day-surveys
#3
Tran Duc Anh Ly, Sophie Edouard, Sekene Badiaga, Herve Tissot-Dupont, Van Thuan Hoang, Vincent Pommier de Santi, Philippe Brouqui, Didier Raoult, Philippe Gautret
OBJECTIVES: To assess risk factors for respiratory tract infection symptoms and signs in sheltered homeless people in Marseille during the winter season, including pathogen carriage. METHODS: Data on 479 male participants within 2 shelters who completed questionnaires and a total of 950 nasal and pharyngeal samples were collected during the winters of 2015-2017. Respiratory pathogen carriage including 7 viruses and 4 bacteria was assessed by quantitative polymerase chain reaction...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29776718/high-urinary-ferritin-reflects-myoglobin-iron-evacuation-in-dmd-patients
#4
Jérémy Rouillon, Thibaud Lefebvre, Jérôme Denard, Vincent Puy, Raed Daher, Jérôme Ausseil, Aleksandar Zocevic, Paul Fogel, Katell Peoc'h, Brenda Wong, Laurent Servais, Thomas Voit, Herve Puy, Zoubida Karim, Fedor Svinartchouk
Duchenne muscular dystrophy (DMD) is an X-linked disease caused by mutations in the dystrophin gene leading to the absence of the normal dystrophin protein. The efforts of many laboratories brought new treatments of DMD to the reality, but ongoing and forthcoming clinical trials suffer from absence of valuable biomarkers permitting to follow the outcome of the treatment day by day and to adjust the treatment if needed. In the present study the levels of 128 urinary proteins including growth factors, cytokines and chemokines were compared in urine of DMD patients and age related control subjects by antibody array approach...
March 20, 2018: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29772613/safety-of-dual-kidney-transplantation-compared-to-single-kidney-transplantation-from-expanded-criteria-donors-a-single-center-cohort-of-39-recipients
#5
Lionel Mendel, Laetitia Albano, Imad Bentellis, Thierry Yandza, Caroline Bernardi, Herve Quintens, Brannwel Tibi, Jacques Jourdan, Matthieu Durand, Jean Amiel, Daniel Chevallier
Our objective was to compare outcomes of DKT to single kidney transplantation (SKT) performed with grafts from expanded criteria donors (ECD) in recipients ≥65 years, focusing on surgical complications. All kidney transplantations (KT) performed between 2006 and 2014 in our institution were analyzed. DKT were indicated according to the criteria of the French national Agence de la Biomedecine. Thirty-nine DKT and 155 SKT were included, with a median follow-up of 36 and 26.5 months, respectively. The rate of early surgical revisions was not significantly higher after DKT (23...
May 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29772015/the-influence-of-spatial-and-temporal-discontinuities-of-forest-habitats-on-the-current-presence-of-flightless-saproxylic-beetles
#6
Eugénie Cateau, Pierre-Alexis Herrault, David Sheeren, Sylvie Ladet, Hervé Brustel
Flightless saproxylic beetles were selected in order to study the impact of temporal and spatial discontinuity of forests. They were chosen because: (1) they are unable to fly, making them dispersal-limited species, (2) they have a saproxylic diet, which means they are closely linked to the forest, and (3), they have rarely been studied. Forest temporal continuity was expected to be the main factor explaining the presence of these species, modulated by the past and present amount of forest in the surrounding landscape...
2018: PloS One
https://www.readbyqxmd.com/read/29765685/discrepancies-in-the-spiking-threshold-and-frequency-sensitivity-of-nocturnal-moths-explainable-by-biases-in-the-canonical-auditory-stimulation-method
#7
Herve Thevenon, Gerit Pfuhl
The auditory stimulation method used in experiments on moth A cell(s) is generally believed to be adequate to characterize the encoding of bat echolocation signals. The stimulation method hosts, though, several biases. Their compounded effects can explain a range of discrepancies between the reported electrophysiological recordings and significantly alter the current interpretation. To test the hypothesis that the bias may significantly alter our current understanding of the moth's auditory transducer characteristics, papers using the same auditory stimulation method and reporting on either spiking threshold or spiking activity of the moth's A cells were analysed...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29763740/combining-magnetic-resonance-imaging-mri-and-medical-infrared-thermography-mit-in-the-pre-and-per-operating-management-of-severe-hidradenitis-suppurativa-hs
#8
Stéphane Derruau, Yohann Renard, Hervé Pron, Redha Taiar, Ellie Abdi, Guillaume Polidori, Sandrine Lorimier
Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurrent skin disease. Surgical excision of wounds appears to be the only curative treatment for the prevention of recurrence of moderate to severe stages. Magnetic resonance imaging (MRI) is a standard reference examination for the detection of HS peri-anal inflammatory fistula. In this case study, the use of real-time medical infrared thermography, in combination with MRI as appropriate imaging, is proposed. The aim is to assist surgeons in the pre- and peri-surgical management of severe perianal hidradenitis suppurativa with the intent to ensure that all diseased lesions were removed during surgery and therefore to limit recurrence...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29762276/short-term-effect-of-low-dose-electromyography-guided-botulinum-toxin-a-injection-in-the-treatment-of-chronic-lateral-epicondylar-tendinopathy-a-randomized-double-blinded-study
#9
Alexandre Creuzé, Hervé Petit, Mathieu de Sèze
BACKGROUND: Botulinum toxin A (BoNT-A) is a novel treatment for chronic lateral epicondylar tendinopathy. Preliminary studies have demonstrated promising results; however, confirmation of the effectiveness of BoNT-A treatment and further assessment of its side effects are required. This study investigated the analgesic effects of BoNT-A in the treatment of chronic lateral epicondylar tendinopathy. METHODS: This was a phase-III, single-center, randomized, double-blinded, placebo-controlled study including 60 patients with chronic lateral epicondylar tendinopathy that had been resistant to treatment for >6 months...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29761698/assessment-of-compressive-raman-versus-hyperspectral-raman-for-microcalcification-chemical-imaging
#10
Camille Scotté, Hilton B de Aguiar, Didier Marguet, Ellen Marie Green, Pascaline Bouzy, Sébastien Vergnole, Charles Peter Winlove, Nicholas Stone, Herve Rigneault
We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are generated with an algorithm based on the Cramer-Rao lower bound. We com-pared the developed CRT microspectrometer with two conventional state-of-the-art Raman hyperspectral imaging systems on samples mimicking microcalcifications relevant for breast cancer diagnosis...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29761116/estimation-of-intrathecal-igg-synthesis-simulation-of-the-risk-of-underestimation
#11
Mickael Bonnan, Mariana Gianoli-Guillerme, Henri Courtade, Stéphanie Demasles, Elsa Krim, Raluca Marasescu, Hervé Dréau, Stéphane Debeugny, Bruno Barroso
Objective: The low level of passively diffused IgG through the blood-brain barrier is sufficient to blur the estimation of intrathecal IgG synthesis (ITS). Therefore, this estimation requires a mathematical calculation derived from empirical laws, but the range of normal values in healthy controls is wide enough to prevent a precise calculation. This study investigated the precision of various methods of ITS estimations and their application to two clinical situations: plasma exchange and immune suppression targeting ITS...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29761115/depdc5-knockdown-causes-mtor-dependent-motor-hyperactivity-in-zebrafish
#12
Hortense de Calbiac, Adriana Dabacan, Elise Marsan, Hervé Tostivint, Gabrielle Devienne, Saeko Ishida, Eric Leguern, Stéphanie Baulac, Raul C Muresan, Edor Kabashi, Sorana Ciura
Objective: DEPDC5 was identified as a major genetic cause of focal epilepsy with deleterious mutations found in a wide range of inherited forms of focal epilepsy, associated with malformation of cortical development in certain cases. Identification of frameshift, truncation, and deletion mutations implicates haploinsufficiency of DEPDC5 in the etiology of focal epilepsy. DEPDC5 is a component of the GATOR1 complex, acting as a negative regulator of mTOR signaling. Methods: Zebrafish represents a vertebrate model suitable for genetic analysis and drug screening in epilepsy-related disorders...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29760213/changes-in-iga-protease-expression-are-conferred-by-changes-in-genomes-during-persistent-infection-by-nontypeable-haemophilus-influenzae-in-chronic-obstructive-pulmonary-disease
#13
Mary C Gallo, Charmaine Kirkham, Samantha Eng, Remon S Bebawee, Yong Kong, Melinda M Pettigrew, Hervé Tettelin, Timothy F Murphy
Nontypeable Haemophilus influenzae (NTHi) is an exclusively human pathobiont that plays a critical role in the course and pathogenesis of chronic obstructive pulmonary disease (COPD). NTHi causes acute exacerbations of COPD and also causes persistent infection of the lower airways. NTHi expresses four IgA protease variants (A1, A2, B1, and B2) that play different roles in virulence. Expression of IgA proteases varies among NTHi strains, but little is known about the frequency and mechanisms by which NTHi modulates IgA protease expression during infection in COPD...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29759974/the-ceramide-transporter-cert-is-involved-in-muscle-insulin-signaling-defects-under-lipotoxic-conditions
#14
Cécile L Bandet, Rana Mahfouz, Julien Véret, Athanassia Sotiropoulos, Maxime Poirier, Paola Giussani, Mélanie Campana, Erwann Philippe, Agnieszka Blachnio-Zabielska, Raphaëlle Ballaire, Xavier Le Liepvre, Olivier Bourron, Dušan Berkeš, Jan Górski, Pascal Ferré, Hervé Le Stunff, Fabienne Foufelle, Eric Hajduch
One main mechanism of insulin resistance (IR), a key feature of type-2 diabetes, is the accumulation of saturated fatty acids (FA) in muscles of obese and type-2 diabetic patients. Understanding the mechanism underlying lipid-induced IR is therefore a crucial challenge. Saturated FA are metabolized into lipid-derivatives called ceramides and their accumulation plays a central role in the development of muscle IR. Ceramides are produced in the endoplasmic reticulum (ER) and transported to the Golgi through a transporter called CERT, where they are converted into different sphingolipid species...
May 14, 2018: Diabetes
https://www.readbyqxmd.com/read/29756692/the-presence-of-elastic-compression-stockings-reduces-the-fluid-responsiveness-of-patients-in-the-operating-room
#15
Elie Zogheib, Julien Maizel, Nabil Cherradi, Ammar Benammar, Béatrice Labont, Abdel Hchikat, Michael Bernasinski, Faouzi Trojette, Michel Slama, Hervé Dupont
BACKGROUND: To investigate whether elastic compression stockings (ECS) can affect fluid responsiveness parameters before and during passive leg raising (PLR) maneuvers. METHODS: In the operating room (OR), we performed a prospective study including patients referred for cardiac surgery. Blood pressure (BP), ΔPP, heart rate (HR), central venous pressure (CVP), stroke volume (SV) and aortic blood flow (ABF) (by esophageal doppler) were measured according to four conditions: supine position without ECS (baseline 1), lower limbs raised to an angle of 45° (PLR 1), returned to the supine position with ECS (baseline 2), then a second PLR maneuver with ECS was performed (PLR 2)...
May 11, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29754291/defence-strategies-in-african-savanna-trees
#16
Benjamin J Wigley, Hervé Fritz, Corli Coetsee
Southern African savannas are commonly polarised into two broad types based on plant functional types and defences; infertile savannas dominated by broad-leaved trees typically defended by nitrogen-free secondary compounds and fertile savannas dominated by fine-leaved trees defended by structural defences. In this study, we use trait and other data from 15 wooded savanna sites in Southern Africa and ask if broad-leaved and fine-leaved species dominate on nutrient-poor and nutrient-rich soils, respectively. We then test if there is there any evidence for trade-offs in chemical (i...
May 12, 2018: Oecologia
https://www.readbyqxmd.com/read/29754287/protective-role-of-the-elovl2-docosahexaenoic-acid-axis-in-glucolipotoxicity-induced-apoptosis-in-rodent-beta-cells-and-human-islets
#17
Lara Bellini, Mélanie Campana, Claude Rouch, Marta Chacinska, Marco Bugliani, Kelly Meneyrol, Isabelle Hainault, Véronique Lenoir, Jessica Denom, Julien Véret, Nadim Kassis, Bernard Thorens, Mark Ibberson, Piero Marchetti, Agnieszka Blachnio-Zabielska, Céline Cruciani-Guglielmacci, Carina Prip-Buus, Christophe Magnan, Hervé Le Stunff
AIMS/HYPOTHESIS: Dietary n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), are known to influence glucose homeostasis. We recently showed that Elovl2 expression in beta cells, which regulates synthesis of endogenous DHA, was associated with glucose tolerance and played a key role in insulin secretion. The present study aimed to examine the role of the very long chain fatty acid elongase 2 (ELOVL2)/DHA axis on the adverse effects of palmitate with high glucose, a condition defined as glucolipotoxicity, on beta cells...
May 12, 2018: Diabetologia
https://www.readbyqxmd.com/read/29753589/development-of-a-highly-sensitive-pcr-dna-chip-method-to-detect-mycoplasmas-in-a-veterinary-modified-live-vaccine
#18
Sylvie Mbelo, Virginie Gay, Stephanie Blanchard, Eric Abachin, Stephanie Falque, Jacques Lechenet, Hervé Poulet, Blandine de Saint-Vis
Mycoplasmas are potential contaminants that introduce undesirable changes in mammalian cell cultures. They frequently contaminate cell substrates and other starting materials used for manufacturing cell-derived biologics, such as vaccines and pharmaceutical products. Mycoplasma purity testing of live vaccines, active ingredients, raw material, and seed lots is required during vaccine production. Previously, testing using a time-consuming, costly 28-day culture assay, which lacks sensitivity for species that do not grow in culture, was required in the European Pharmacopoeia (Ph...
May 9, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29749396/long-intergenic-non-coding-rnas-have-an-independent-impact-on-survival-in-multiple-myeloma
#19
Mehmet Kemal Samur, Stephane Minvielle, Annamaria Gulla, Mariateresa Fulciniti, Alice Cleynen, Anil Aktas Samur, Raphael Szalat, Masood Shammas, Florence Magrangeas, Yu-Tzu Tai, Daniel Auclair, Jonathan Keats, Paul Richardson, Michel Attal, Philippe Moreau, Kenneth C Anderson, Giovanni Parmigiani, Hervé Avet-Loiseau, Nikhil C Munshi
Although long intergenic non-coding RNAs (lincRNA) role in various cancers is described, their significance in Multiple Myeloma (MM) remains poorly defined. Here we have studied the lincRNA profile and their clinical impact in MM. We performed RNA-seq on MM cells from 308 newly diagnosed and uniformly treated patients, 16 normal plasma cells and utilized RNA-seq data from 532 newly diagnosed patients from CoMMpass study to analyze for lincRNAs. We observed 869 differentially expressed lincRNAs in MM compared to normal plasma cells...
March 29, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29749030/a-new-therapeutic-approach-for-type-1-diabetes-rationale-for-gnbac1-an-anti-herv-w-env-monoclonal-antibody
#20
REVIEW
Francois Curtin, Corinne Bernard, Sandrine Levet, Hervé Perron, Hervé Porchet, Julie Médina, Sam Malpass, David Lloyd, Richard Simpson
We describe a newly identified therapeutic target for type 1 diabetes: an envelope protein of endogenous retroviral origin called Human Endogenous Retrovirus W Envelope (HERV-W-Env). HERV-W-Env was found to be detected in the blood of around 60% of type 1 diabetes (T1D) patients and is expressed in acinar pancreatic cells of 75% of T1D patients at post-mortem examination. Preclinical experiments showed that this protein displays direct cytotoxicity on human β-islet cells. In vivo HERV-W-Env impairs the insulin and glucose metabolism in transgenic mice expressing HERV-W-Env...
May 10, 2018: Diabetes, Obesity & Metabolism
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