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https://www.readbyqxmd.com/read/28227392/structural-and-functional-changes-during-epileptogenesis-in-the-mouse-model-of-medial-temporal-lobe-epilepsy
#1
Yvan Dietrich, Pierre-Antoine Eliat, Gabriel Dieuset, Herve Saint-Jalmes, Charles Pineau, Fabrice Wendling, Benoit Martin, Yvan Dietrich, Pierre-Antoine Eliat, Gabriel Dieuset, Herve Saint-Jalmes, Charles Pineau, Fabrice Wendling, Benoit Martin, Pierre-Antoine Eliat, Charles Pineau, Benoit Martin, Gabriel Dieuset, Yvan Dietrich, Herve Saint-Jalmes, Fabrice Wendling
An important issue in epilepsy research is to understand the structural and functional modifications leading to chronic epilepsy, characterized by spontaneous recurrent seizures, after initial brain insult. To address this issue, we recorded and analyzed electroencephalography (EEG) and quantitative magnetic resonance imaging (MRI) data during epileptogenesis in the in vivo mouse model of Medial Temporal Lobe Epilepsy (MTLE, kainate). Besides, this model of epilepsy is a particular form of drug-resistant epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227077/optimal-control-of-inspired-perfluorocarbon-temperature-for-induction-of-hypothermia-by-total-liquid-ventilation-in-juvenile-lamb-model
#2
Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Michael Sage, Philippe Micheau, Jean-Paul Praud, Mathieu Nadeau, Herve Walti, Renaud Tissier
Mild hypothermia is well known for its therapeutic value in cardio- and neuroprotection. Many recent experimental studies have shown that the swiftness of the cooling offered by total liquid ventilation (TLV) holds great promise in achieving maximal therapeutic effect. TLV is an emerging ventilation technique in which the lungs are filled with breathable liquids, namely perfluorocarbons (PFCs). A liquid ventilator ensures subject ventilation by periodically renewing a volume of oxygenated, CO2-free and temperature-controlled breathable PFC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225162/mandibular-position-and-movements-suitability-for-diagnosis-of-sleep-apnoea
#3
Jean-Benoit Martinot, Jean-Christian Borel, Valérie Cuthbert, Hervé Jean-Pierre Guénard, Stéphane Denison, Philip E Silkoff, David Gozal, Jean-Louis Pepin
BACKGROUND AND OBJECTIVE: Mandibular movements (MMs) and position during sleep reflect respiratory efforts related to increases in upper airway resistance and micro-arousals. The study objective was to assess whether MM identifies sleep-disordered breathing (SDB) in patients with moderate to high pre-test probability. METHODS: This was a prospective study of 87 consecutive patients referred for an in-laboratory sleep test. Magnetometer-derived MM signals were incorporated into standard polysomnography (PSG)...
November 6, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28223229/theranostic-of-biopharmaceuticals
#4
REVIEW
Benjamin Chaigne, Hervé Watier
Monoclonal antibodies (mAbs) and fusion proteins with an Fc portion of immunoglobulin G (IgG) are emblematic of the remarkable expansion of biopharmaceuticals. Despite their biological origin, these products display an interindividual variability in their efficacy and/or side effects, which must be taken into consideration. Biological monitoring allowing for adapted prescription and dose adjustments may lead to therapeutic optimization and limitation of the high costs of these drugs. Herein, we review the biological theranostic of mAbs and Fc fusion proteins, including pre-treatment analyses, monitoring of efficacy, therapeutic drug monitoring, and monitoring of side effects...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28222829/assessing-the-likelihood-of-hand-to-hand-cross-transmission-of-bacteria-an-experimental-study
#5
Fernando Bellissimo-Rodrigues, Daniela Pires, Hervé Soule, Angèle Gayet-Ageron, Didier Pittet
BACKGROUND Although the hands of healthcare workers (HCWs) are implicated in most episodes of healthcare-associated infections, the correlation between hand contamination and the likelihood of cross-transmission remains unknown. METHODS We conducted a laboratory-based study involving pairs of HCWs. The hands of a HCW (transmitter) were contaminated with Escherichia coli ATCC 10536 before holding hands with another HCW (host) for 1 minute. Meanwhile, the unheld hand of the transmitter was sampled. Afterward, the host's held hand was also sampled...
February 22, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28221862/randomized-phase-ii-study-of-clofarabine-based-consolidation-for-younger-adults-with-acute-myeloid-leukemia-in-first-remission
#6
Xavier Thomas, Stéphane de Botton, Sylvie Chevret, Denis Caillot, Emmanuel Raffoux, Emilie Lemasle, Jean-Pierre Marolleau, Céline Berthon, Arnaud Pigneux, Norbert Vey, Oumedaly Reman, Marc Simon, Christian Recher, Jean-Yves Cahn, Olivier Hermine, Sylvie Castaigne, Karine Celli-Lebras, Norbert Ifrah, Claude Preudhomme, Christine Terré, Hervé Dombret
Purpose To evaluate the efficacy and safety of a clofarabine-based combination (CLARA) versus conventional high-dose cytarabine (HDAC) as postremission chemotherapy in younger patients with acute myeloid leukemia (AML). Patients and Methods Patients age 18 to 59 years old with intermediate- or unfavorable-risk AML in first remission and no identified donor for allogeneic stem-cell transplantation (SCT) were eligible. Two hundred twenty-one patients were randomly assigned to receive three CLARA or three HDAC consolidation cycles...
February 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28220314/supportive-care-organization-in-france-a-national-in-depth-survey-among-patients-and-oncologists
#7
Florian Scotté, Christian Hervé, Pauline Leroy, Jean-Marc Tourani, René-Jean Bensadoun, Marie-Eve Bugat, Fadila Farsi, Nicolas Jovenin, Moïse Namer, Christophe Tournigand, Sophie Morin, Cloé Brami, Stéphane Oudard, Alexandre Saadi, Ivan Krakowski
PURPOSE: Medical doctors' (MDs), but not patients', perception of supportive care in cancer (SCC) in France has been previously assessed in a national survey. This study evaluated MDs and patients' perceptions of the SCC organization and implementation in France. METHODS: The French SCC Association conducted two observational studies: study 1 (S1), containing a 30-point questionnaire sent to 2263 MDs, and study 2 (S2), containing a 40-point questionnaire sent to 2000 patients...
February 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28214919/grapevine-acclimation-to-water-deficit-the-adjustment-of-stomatal-and-hydraulic-conductance-differs-from-petiole-embolism-vulnerability
#8
Uri Hochberg, Andrea Giulia Bonel, Rakefet David-Schwartz, Asfaw Degu, Aaron Fait, Hervé Cochard, Enrico Peterlunger, Jose Carlos Herrera
Drought-acclimated vines maintained higher gas exchange compared to irrigated controls under water deficit; this effect is associated with modified leaf turgor but not with improved petiole vulnerability to cavitation. A key feature for the prosperity of plants under changing environments is the plasticity of their hydraulic system. In the present research we studied the hydraulic regulation in grapevines (Vitis vinifera L.) that were first acclimated for 39 days to well-watered (WW), sustained water deficit (SD), or transient-cycles of dehydration-rehydration-water deficit (TD) conditions, and then subjected to varying degrees of drought...
February 18, 2017: Planta
https://www.readbyqxmd.com/read/28214070/microbiote-intestinal%C3%A2-qu%C3%A2-en-attendre-au-plan-physiologique-et-th%C3%A3-rapeutique%C3%A2
#9
Joël Doré, Marie-Christine Multon, Jehan-Michel Béhier, Hervé Affagard, Antoine Andremont, Philippe Barthélémy, Rui Batista, Marc Bonneville, Christophe Bonny, Gwendoline Boyaval, Mathias Chamaillard, Marie-Pierre Chevalier, Magali Cordaillat-Simmons, Fabienne Cournarie, Isabelle Diaz, Elisabeth Guillaume, Cyril Guyard, Evelyne Jouvin-Marche, François-Pierre Martin, David Petiteau
No abstract text is available yet for this article.
January 11, 2017: Thérapie
https://www.readbyqxmd.com/read/28214006/-conduct-of-epidemiologic-studies-in-french-cancer-survivors-methods-difficulties-encountered-and-solutions-provided-lessons-learned-from-the-simonal-study-on-long-term-toxicities-after-non-hodgkin-lymphoma-treatment
#10
Sabine Anthony, Pierre Hebel, André Garrel, Vanina Oliveri, Catherine Thieblemont, Vincent Ribrag, Hervé Tilly, Corinne Haioun, René-Olivier Casasnovas, Franck Morschhauser, Pierre Feugier, Richard Delarue, Loic Ysebaert, Catherine Sebban, Florence Broussais, Gandhi Damaj, Virginie Nerich, Jean-Philippe Jais, Gilles Salles, Michel Henry-Amar, Nicolas Mounier
INTRODUCTION: Since the introduction of targeted therapies, specific lymphoma mortality has decreased. Possible long-term toxicities, however, are not known yet. This article describes the implementation of the SIMONAL study that investigates the hypothesis of an overconsumption of care after lymphoma treatment with a 10-year follow-up. METHODS: After the mandatory regulatory steps (CCTIRS and CNIL) the vital status and address of 5247 patients treated in 131 French centers were retrieved using a secure web portal, in order to send a quality of life after lymphoma questionnaire...
February 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28213378/prognostic-role-of-circulating-exosomal-mirnas-in-multiple-myeloma
#11
Salomon Manier, Chia-Jen Liu, Hervé Avet-Loiseau, Jihye Park, Jiantao Shi, Federico Campigotto, Karma Z Salem, Daisy Huynh, Siobhan V Glavey, Bradley Rivotto, Antonio Sacco, Aldo M Roccaro, Juliette Bouyssou, Stéphane Minvielle, Philippe Moreau, Thierry Facon, Xavier Leleu, Edie Weller, Lorenzo Trippa, Irene M Ghobrial
Exosomes, secreted by several cell types, including cancer cells, can be isolated from the peripheral blood and have been shown to be powerful markers of disease progression in cancer. In this study, we examined the prognostic significance of circulating exosomal microRNAs (miRNAs) in multiple myeloma (MM). A cohort of 156 patients with newly diagnosed MM, uniformly treated and followed, was studied. Circulating exosomal miRNAs were isolated and used to perform small RNA sequencing analysis on 10 samples and a qRT-PCR array on 156 samples...
February 17, 2017: Blood
https://www.readbyqxmd.com/read/28212292/azacitidine-for-front-line-therapy-of-patients-with-aml-reproducible-efficacy-established-by-direct-comparison-of-international-phase-3-trial-data-with-registry-data-from-the-austrian-azacitidine-registry-of-the-agmt-study-group
#12
Lisa Pleyer, Hartmut Döhner, Hervé Dombret, John F Seymour, Andre C Schuh, C L Beach, Arlene S Swern, Sonja Burgstaller, Reinhard Stauder, Michael Girschikofsky, Heinz Sill, Konstantin Schlick, Josef Thaler, Britta Halter, Sigrid Machherndl Spandl, Armin Zebisch, Angelika Pichler, Michael Pfeilstöcker, Eva M Autzinger, Alois Lang, Klaus Geissler, Daniela Voskova, Wolfgang R Sperr, Sabine Hojas, Inga M Rogulj, Johannes Andel, Richard Greil
We recently published a clinically-meaningful improvement in median overall survival (OS) for patients with acute myeloid leukaemia (AML), >30% bone marrow (BM) blasts and white blood cell (WBC) count ≤15 G/L, treated with front-line azacitidine versus conventional care regimens within a phase 3 clinical trial (AZA-AML-001; NCT01074047; registered: February 2010). As results obtained in clinical trials are facing increased pressure to be confirmed by real-world data, we aimed to test whether data obtained in the AZA-AML-001 trial accurately represent observations made in routine clinical practice by analysing additional AML patients treated with azacitidine front-line within the Austrian Azacitidine Registry (AAR; NCT01595295; registered: May 2012) and directly comparing patient-level data of both cohorts...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28210884/energy-balance-and-obesity-what-are-the-main-drivers
#13
Isabelle Romieu, Laure Dossus, Simón Barquera, Hervé M Blottière, Paul W Franks, Marc Gunter, Nahla Hwalla, Stephen D Hursting, Michael Leitzmann, Barrie Margetts, Chizuru Nishida, Nancy Potischman, Jacob Seidell, Magdalena Stepien, Youfa Wang, Klaas Westerterp, Pattanee Winichagoon, Martin Wiseman, Walter C Willett
PURPOSE: The aim of this paper is to review the evidence of the association between energy balance and obesity. METHODS: In December 2015, the International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group of international experts to review the evidence regarding energy balance and obesity, with a focus on Low and Middle Income Countries (LMIC). RESULTS: The global epidemic of obesity and the double burden, in LMICs, of malnutrition (coexistence of undernutrition and overnutrition) are both related to poor quality diet and unbalanced energy intake...
February 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28207953/sgs1-a-neomorphic-nac52-allele-impairing-ptgs-through-sgs3-down-regulation
#14
Nicolas Butel, Ivan Le Masson, Nathalie Bouteiller, Hervé Vaucheret, Taline Elmayan
Post-transcriptional gene silencing (PTGS) is a defense mechanism that targets invading nucleic acids from endogenous (transposons) or exogenous (pathogens, transgenes) origins. Genetic screens based on the reactivation of silenced transgenes have long been used to identify cellular PTGS components and regulators. Here we show that the first isolated PTGS-deficient mutant, sgs1, is impaired in the transcription factor NAC52. This mutant exhibits striking similarities with a mutant impaired in the H3K4me3 demethylase JMJ14 isolated from the same genetic screen...
February 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28207850/the-association-between-human-endogenous-retroviruses-and-multiple-sclerosis-a-systematic-review-and-meta-analysis
#15
Elena Morandi, Radu Tanasescu, Rachael E Tarlinton, Cris S Constantinescu, Weiya Zhang, Christopher Tench, Bruno Gran
BACKGROUND: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. OBJECTIVE: To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients. METHODS: Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS...
2017: PloS One
https://www.readbyqxmd.com/read/28207736/congenital-toxoplasmosis-in-france-and-the-united-states-one-parasite-two-diverging-approaches
#16
Francois Peyron, Rima Mc Leod, Daniel Ajzenberg, Despina Contopoulos-Ioannidis, François Kieffer, Laurent Mandelbrot, L David Sibley, Hervé Pelloux, Isabelle Villena, Martine Wallon, Jose G Montoya
No abstract text is available yet for this article.
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28204806/paediatric-bone-and-joint-infections-in-french-guiana-a-6-year-retrospective-review
#17
Lindsay Osei, Nawal El Houmami, Philippe Minodier, Anicet Sika, Thierry Basset, Hervé Seligmann, Anne Terraz, Magalie Demar, Jacques Pochard, Jérôme Clouzeau, Pierre-Edouard Fournier, Narcisse Elenga
No abstract text is available yet for this article.
February 15, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28204765/cross-cultural-validation-of-lupus-impact-tracker-in-five-european-clinical-practice-settings
#18
Matthias Schneider, Marta Mosca, José-Maria Pego-Reigosa, Iva Gunnarsson, Frédérique Maurel, Anna Garofano, Alessandra Perna, Rolando Porcasi, Hervé Devilliers
No abstract text is available yet for this article.
February 14, 2017: Rheumatology
https://www.readbyqxmd.com/read/28203488/efficacy-and-safety-of-clairyg-%C3%A2-a-ready-to-use-intravenous-immunoglobulin-in-adult-patients-with-primary-immune-thrombocytopenia
#19
Borhane Slama, Olivier Fain, Hervé Maisonneuve, Eric Jourdan, Jean-François Viallard, Rabye Ouaja, Ousmane Alfa-Cissé, Bertrand Godeau
PURPOSE: The present study was designed to assess the efficacy and safety of IGNG that is a new liquid, saccharose and maltose-free highly purified ready-to-use 5% intravenous immunoglobulin (IVIg), in primary immune thrombocytopenic patients with severe thrombocytopenia. METHODS: Nineteen adults with a platelet count ≤ 25 × 10(9)/L received a single dose of IGNG (1 g/kg) on Day 1, with a second identical dose on Day 3 if needed. Patients were followed for 30 days...
2017: American Journal of Blood Research
https://www.readbyqxmd.com/read/28197999/parallel-experimental-design-and-multivariate-analysis-provides-efficient-screening-of-cell-culture-media-supplements-to-improve-biosimilar-product-quality
#20
David Brühlmann, Michael Sokolov, Alessandro Butté, Markus Sauer, Jürgen Hemberger, Jonathan Souquet, Hervé Broly, Martin Jordan
Rational and high-throughput optimization of mammalian cell culture media has a great potential to modulate recombinant protein product quality. We present a process design method based on parallel design-of-experiment (DoE) of CHO fed-batch cultures in 96-deepwell plates to modulate monoclonal antibody (mAb) glycosylation using medium supplements. To reduce risk of losing valuable information in an intricate joint screening, 17 compounds were separated into five different groups, considering their mode of biological action...
February 15, 2017: Biotechnology and Bioengineering
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