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https://www.readbyqxmd.com/read/28549220/physiological-responses-during-intermittent-running-exercise-differ-between-outdoor-and-treadmill-running
#1
Marco Panascì, Romuald Lepers, Antonio La Torre, Matteo Bonato, Hervè Assadi
The aim of this study was to compare the physiological responses during 15 min of intermittent running consisting of 30 s high intensity running exercise at maximal aerobic velocity (MAV) interspersed with 30 s passive recovery (30-30) performed outdoor versus on a motorized treadmill. Fifteen collegiate physically active males (age: 22±1 years-old; body mass: 66±7 kg; stature: 176±06 cm, weekly training volume: 5±2 h·week<sup>-1</sup>), performed Fitness Intermittent test 45-15 in order to determine VO<sub>2max</sub> and Maximal Aerobic Velocity (MAV) and then completed in random order three different training sessions consisting of 30s run -30s rest outdoor on athletic track (30-30 Track) at MAV; 30s run -30s rest on treadmill (30-30 Treadmill) at MAV; 30s run -30s rest at MAV+15% (30-30+15% MAV Treadmill)...
May 26, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28549141/risk-factors-for-acquisition-of-ctx-m-genes-in-pilgrims-during-hajj-2013-and-2014
#2
Thongpan Leangapichart, Hervé Tissot-Dupont, Didier Raoult, Ziad A Memish, Jean-Marc Rolain, Philippe Gautret
Background: Mass gatherings, especially the Hajj pilgrimage, provide favourable conditions for bacterial transmission among participants, which might contribute to the international spread of ESBL-producing Enterobacteriaceae (ESBL-E). Objectives: We conducted an analysis aimed at investigating risk factors for CTX-M gene ( bla CTX-M ) rectal carriage in 2013 and 2014 Hajj pilgrims. Methods: A total of 218 pilgrims provided paired pre- and post-Hajj rectal samples (2013, 129 pilgrims; 2014, 89 pilgrims)...
May 26, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28546310/heterozygous-gnal-mice-are-a-novel-animal-model-to-study-dystonia-pathophysiology
#3
Assunta Pelosi, Fabien Menardy, Daniela Popa, Jean-Antoine Girault, Denis Hervé
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions. Its pathophysiological mechanisms are still poorly understood. Dominant mutations of the GNAL gene are a cause of isolated dystonia (DYT25) in patients. Some mutations result in a complete loss of function of the encoded protein, Gαolf, an adenylyl-cyclase-stimulatory G protein highly enriched in striatal projection neurons, in which it mediates the actions of dopamine and adenosine. We used male and female heterozygous Gnal knockout mice (Gnal+/-) to study how GNAL haplodeficiency is implicated in dystonia...
May 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28543998/hexakis-60-fullerene-adduct-mediated-covalent-assembly-of-ruthenium-nanoparticles-and-their-catalytic-properties
#4
Philippe Serp, Faqiang Leng, Iann C Gerber, Pierre Lecante, Ahmed Bentaleb, Antonio Muñoz, Beatriz M Illescas, Nazario Martín, Georgian Melinte, Ovidiu Ersen, Hervé Martinez, M Rosa Axet
The C66(COOH)12 hexa-adduct has been successfully used as a building block to construct, via carboxylate bridges, 3D networks with very homogeneous sub-1.8 nm ruthenium nanoparticles. This strategy allows the control of the interparticle distance. The obtained nanostructures are active in nitrobenzene selective hydrogenation.
May 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28542843/next-generation-sequencing-of-a-family-with-a-high-penetrance-of-monoclonal-gammopathies-for-the-identification-of-candidate-risk-alleles
#5
Niccolo Bolli, Matteo Barcella, Erika Salvi, Francesca D'Avila, Antonio Vendramin, Chiara De Philippis, Nikhil C Munshi, Herve Avet-Loiseau, Peter J Campbell, Alberto Mussetti, Cristiana Carniti, Francesco Maura, Cristina Barlassina, Paolo Corradini, Vittorio Montefusco
BACKGROUND: The authors describe a family with a high penetrance of plasma cell dyscrasias, suggesting inheritance of an autosomal dominant risk allele. METHODS: The authors performed whole-exome sequencing and reported on a combined approach aimed at the identification of causative variants and risk loci, using the wealth of data provided by this approach. RESULTS: The authors identified gene mutations and single-nucleotide polymorphisms of potential significance, and pinpointed a known risk locus for myeloma as a potential area of transmissible risk in the family...
May 23, 2017: Cancer
https://www.readbyqxmd.com/read/28542724/viruses-and-endogenous-retroviruses-in-multiple-sclerosis-from-correlation-to-causation
#6
REVIEW
A-F A Mentis, E Dardiotis, N Grigoriadis, E Petinaki, G M Hadjigeorgiou
Multiple sclerosis is an immune-mediated disease with an environmental component. According to a long-standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (MS) at the end of the 19th century, viruses are either directly or indirectly implicated in MS pathogenesis. Whether viruses in MS are principally causal or simply contributory remains to be proven, but many viruses or viral elements-predominantly Epstein-Barr virus, human endogenous retroviruses (HERVs) and human herpesvirus 6 (HHV-6) but also less common viruses such as Saffold and measles viruses-are associated with MS...
May 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28542137/dt-13-synergistically-enhanced-vinorelbine-mediated-mitotic-arrest-through-inhibition-of-foxm1-bicd2-axis-in-non-small-cell-lung-cancer-cells
#7
Hongyang Li, Li Sun, Hang Li, Xiaodan Lv, Herve Semukunzi, Ruiming Li, Jun Yu, Shengtao Yuan, Sensen Lin
Non-small-cell lung cancer (NSCLC) is the most commonly diagnosed malignant disease with the leading cause of cancer-related death. Combination treatment remains the major strategy in the clinical therapy of NSCLC. Vinorelbine (NVB), a semi-synthetic vinca alkaloid, is used for advanced and metastatic NSCLC by destabilizing microtubule formation to induce mitotic arrest and cell death. However, the side effect of NVB heavily affected its effectiveness in clinical therapy. Hence, it is of great significance to develop new agents to synergize with NVB and decrease the adverse effect...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28539933/mal-de-r%C3%A3-o-cuarto-virus-infection-triggers-the-production-of-distinctive-viral-derived-sirna-profiles-in-wheat-and-its-planthopper-vector
#8
Luis A de Haro, Analía D Dumón, María F Mattio, Evangelina Beatriz Argüello Caro, Gabriela Llauger, Diego Zavallo, Hervé Blanc, Vanesa C Mongelli, Graciela Truol, María-Carla Saleh, Sebastián Asurmendi, Mariana Del Vas
Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus infection. For this purpose, we characterized the sRNA profiles of wheat and planthopper vectors infected by Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae) and quantified virus genome segments by quantitative reverse transcription PCR We provide evidence that plant and insect silencing machineries differentially recognize the viral genome, thus giving rise to distinct profiles of virus-derived small interfering RNAs (vsiRNAs)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28539440/uncovering-the-repertoire-of-endogenous-flaviviral-elements-in-aedes-mosquito-genomes
#9
Yasutsugu Suzuki, Lionel Frangeul, Laura B Dickson, Hervé Blanc, Yann Verdier, Joelle Vinh, Louis Lambrechts, Maria-Carla Saleh
Endogenous viral elements derived from non-retroviral RNA viruses were described in various animal genomes. Whether they have a biological function such as host immune protection against related viruses is a field of intense study. Here, we investigated the repertoire of endogenous flaviviral elements (EFVEs) in Aedes mosquitoes, the vectors of arboviruses such as dengue and chikungunya viruses. Previous studies identified three EFVEs from Ae. albopictus and one from Ae. aegypti cell lines. However, in-depth characterization of EFVEs in wild-type mosquito populations and individuals in vivo has not been performed...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28534234/functional-outcome-of-patients-with-prolonged-hypoglycemic-encephalopathy
#10
Guillaume Barbara, Bruno Mégarbane, Laurent Argaud, Guillaume Louis, Nicolas Lerolle, Francis Schneider, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot, Pierre-Edouard Bollaert
BACKGROUND: Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy. METHODS: In a multicenter retrospective study conducted in patients hospitalized from July 1, 2004, to July 1, 2014, we investigated functional long-term prognosis and identified prognosis factors of patients admitted in an intensive care unit (ICU) with prolonged neurological manifestations related to hypoglycemia...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28531832/fighting-falsified-medicines-the-analytical-approach
#11
REVIEW
Hervé Rebiere, Pauline Guinot, Denis Chauvey, Charlotte Brenier
Given the harm to human health, the fight against falsified medicines has become a priority issue that involves numerous actors. Analytical laboratories contribute by performing analyses to chemically characterise falsified samples and assess their hazards for patients. A wide range of techniques can be used to obtain individual information on the organic and inorganic composition, the presence of an active substance or impurities, or the crystalline arrangement of the formulation's compound. After a presentation of these individual techniques, this review puts forward a methodology to combine them...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28530551/angular-velocity-integration-in-a-fly-heading-circuit
#12
Daniel Turner-Evans, Stephanie Wegener, Hervé Rouault, Romain Franconville, Tanya Wolff, Johannes D Seelig, Shaul Druckmann, Vivek Jayaraman
Many animals maintain an internal representation of their heading as they move through their surroundings. Such a compass representation was recently discovered in a neural population in the Drosophila melanogaster central complex, a brain region implicated in spatial navigation. Here, we use two-photon calcium imaging and electrophysiology in head-fixed walking flies to identify a different neural population that conjunctively encodes heading and angular velocity, and is excited selectively by turns in either the clockwise or counterclockwise direction...
May 22, 2017: ELife
https://www.readbyqxmd.com/read/28528548/taylor-dispersion-analysis-of-polysaccharides-using-backscattering-interferometry
#13
Phoonthawee Saetear, Joseph Chamieh, Michael N Kammer, Thomas J Manuel, Jean-Philippe Biron, Darryl J Bornhop, Hervé Cottet
Taylor Dispersion Analysis (TDA) allows the determination of the molecular diffusion coefficient (D) or the hydrodynamic radius (Rh) of a solute from the peak broadening of a plug of solute in a laminar Poiseuille flow. The main limitation plagu-ing the broader applicability of TDA is the lack of a sensitive detection modality. UV absorption is typically used with TDA, but is only suitable for UV-absorbing or derivatized compounds. In this work, we present a development of TDA method for non-UV absorbing compounds by using a universal detector based on refractive index (RI) sensing with backscattering inter-ferometry (BSI)...
May 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28528280/aortic-involvement-in-relapsing-polychondritis
#14
Maëlle Le Besnerais, Laurent Arnaud, Jonathan Boutémy, Boris Bienvenu, Hervé Lévesque, Zahir Amoura, Isabelle Marie
OBJECTIVE: To assess prevalence of aortic involvement in relapsing polychondritis (RP) patients; to evaluate clinical features and long-term outcome of RP patients exhibiting aortitis, aortic ectasia and/or aneurysm. METHODS: 172 RP patients underwent aortic computed tomography (CT)-scan; they were seen in 3 medical centers. RESULTS: 11 patients (6.4%) had aortic involvement, occurring within a median time of 2 years after RP diagnosis. CT-scan showed isolated aortitis (n=2); the 9 other patients exhibited: aortitis and aortic aneurysm (n=2) or ectasia (n=1), isolated aortic aneurysm (n=4) or ectasia (n=2); aortic localizations were as follows: thoracic (n=6), abdominal (n=2), thoracic and abdominal (n=4) aorta...
May 17, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28527636/shared-decision-making-in-west-africa-the-forgotten-area
#15
Ndeye Thiab Diouf, Ali Ben Charif, Lionel Adisso, Rhéda Adekpedjou, Hervé Tchala Vignon Zomahoun, Tatiana Titilayo Agbadjé, Mama Joyce Dogba, Mirjam Marjolein Garvelink
Up to now, little attention has been paid to West Africa when it comes to shared decision making (SDM). West African countries seem to lag behind with regard to SDM initiatives compared to many other countries in the world. There is some interest in informed decision-making or informed consent, but little in a full SDM process. Few decision-making tools are available for healthcare professionals and the majority are not designed to support decision-making with patients. Furthermore, to the best of our knowledge, there are no training programs for implementing SDM in healthcare teams...
May 18, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28527420/factors-predictive-of-locoregional-recurrence-following-neoadjuvant-chemotherapy-in-patients-with-large-operable-or-locally-advanced-breast-cancer-an-analysis-of-the-eortc-10994-big-1-00-study
#16
Pauline Gillon, Nathan Touati, Christel Breton-Callu, Leen Slaets, David Cameron, Hervé Bonnefoi
PURPOSE: Identification of clinicopathological factors predicting for a locoregional recurrence (LRR) after neoadjuvant chemotherapy (NAC) could help to decide on the optimal locoregional radiotherapy. The objective of this trial is to identify those factors in the context of a phase III trial (European Organisation for Research and Treatment of Cancer 10994). METHODS: Patients received NAC followed by surgery with or without radiotherapy. Radiotherapy was administered according to pre-specified guidelines...
May 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28526583/the-connexin-43-c-terminus-a-tail-of-many-tales
#17
REVIEW
Edward Leithe, Marc Mesnil, Trond Aasen
Connexins are chordate gap junction channel proteins that, by enabling direct communication between the cytosols of adjacent cells, create a unique cell signalling network. Gap junctional intercellular communication (GJIC) has important roles in controlling cell growth and differentiation and in tissue development and homeostasis. Moreover, several non-canonical connexin functions unrelated to GJIC have been discovered. Of the 21 members of the human connexin family, connexin 43 (Cx43) is the most widely expressed and studied...
May 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28526367/discovery-of-a-novel-aminopyrazine-series-as-selective-pi3k%C3%AE-inhibitors
#18
Bernard Barlaam, Sabina Cosulich, Martina Fitzek, Hervé Germain, Stephen Green, Lyndsey L Hanson, Craig S Harris, Urs Hancox, Kevin Hudson, Christine Lambert-van der Brempt, Maryannick Lamorlette, Françoise Magnien, Gilles Ouvry, Ken Page, Linette Ruston, Lara Ward, Bénédicte Delouvrié
We report the discovery of a novel aminopyrazine series of PI3Kα inhibitors, designed by hybridizing two known scaffolds of PI3K inhibitors. We describe the progress achieved from the first compounds plagued with poor general kinase selectivity to compounds showing high selectivity for PI3Kα over PI3Kβ and excellent general kinase selectivity. This effort culminated with the identification of compound 5 displaying high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration...
May 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28525304/minimal-residual-disease-negativity-is-a-new-end-point-of-myeloma-therapy
#19
Jean-Luc Harousseau, Herve Avet-Loiseau
No abstract text is available yet for this article.
May 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28521907/chronic-diseases-in-cats-from-the-medieval-site-of-qalh%C3%A3-t-oman
#20
Hervé Monchot, Claude Guintard
Paleopathological information observed in cats (Felis catus, L. 1758) is rarely described in zooarcheological assemblages. This article is intended to present different bone diseases (infections, degenerative and traumatic lesions) affecting several bones (i.e. femur, hip bone, skull, etc.) of at least two cats from the medieval harbor site of Qalhât (Oman) and to inform us about the health status of these felines.
June 2017: International Journal of Paleopathology
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