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https://www.readbyqxmd.com/read/28727631/one-year-of-baclofen-in-100-patients-with-or-without-cirrhosis-a-french-real-life-experience
#1
Camille Barrault, Hortensia Lison, Françoise Roudot-Thoraval, Armand Garioud, Charlotte Costentin, Véronique Béhar, Mourad Medmoun, Georges Pulwermacher, Hervé Hagège, Jean-François Cadranel
BACKGROUND: Several studies have suggested the efficacy of baclofen in reducing alcohol consumption, leading to a temporary recommendation for use in France. AIM: Our aim was to report our experience in using baclofen in alcohol-dependant patients with or without liver cirrhosis. PATIENTS AND METHODS: Consecutive patients from two liver and alcohol units were recruited over a 3-year period and received increasing doses of baclofen associated with social, psychological, and medical care...
July 19, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28726854/erratum-the-gut-microbiota-a-major-player-in-the-toxicity-of-environmental-pollutants
#2
Sandrine P Claus, Hervé Guillou, Sandrine Ellero-Simatos
[This corrects the article DOI: 10.1038/npjbiofilms.2016.3.].
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/28726614/occupational-exposures-to-ebola-virus-in-ebola-treatment-center-conakry-guinea
#3
Hélène Savini, Frédéric Janvier, Ludovic Karkowski, Magali Billhot, Marc Aletti, Julien Bordes, Fassou Koulibaly, Pierre-Yves Cordier, Jean-Marie Cournac, Nancy Maugey, Nicolas Gagnon, Jean Cotte, Audrey Cambon, Christine Mac Nab, Sophie Moroge, Claire Rousseau, Vincent Foissaud, Thierry De Greslan, Hervé Granier, Gilles Cellarier, Eric Valade, Philippe Kraemer, Philippe Alla, Audrey Mérens, Emmanuel Sagui, Thierry Carmoi, Christophe Rapp
We report 77 cases of occupational exposures for 57 healthcare workers at the Ebola Treatment Center in Conakry, Guinea, during the Ebola virus disease outbreak in 2014-2015. Despite the high incidence of 3.5 occupational exposures/healthcare worker/year, only 18% of workers were at high risk for transmission, and no infections occurred.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28724465/visual-speech-fills-in-both-discrimination-and-identification-of-non-intact-auditory-speech-in-children
#4
Susan Jerger, Markus F Damian, Rachel P McAlpine, Hervé Abdi
To communicate, children must discriminate and identify speech sounds. Because visual speech plays an important role in this process, we explored how visual speech influences phoneme discrimination and identification by children. Critical items had intact visual speech (e.g. bæz) coupled to non-intact (excised onsets) auditory speech (signified by /-b/æz). Children discriminated syllable pairs that differed in intactness (i.e. bæz:/-b/æz) and identified non-intact nonwords (/-b/æz). We predicted that visual speech would cause children to perceive the non-intact onsets as intact, resulting in more same responses for discrimination and more intact (i...
July 20, 2017: Journal of Child Language
https://www.readbyqxmd.com/read/28723791/arthritis-secondary-to-meningococcal-disease-a-case-series-of-7-patients
#5
Vanina Masson-Behar, Hervé Jacquier, Pascal Richette, Jean-Marc Ziza, Valérie Zeller, Christophe Rioux, Baptiste Coustet, Philippe Dieudé, Sébastien Ottaviani
Arthritis secondary to invasive meningococcemia is rare and has been described as a direct result of bacteremia or as immunoallergic-type arthritis, related to the immune complex. Only a few case series have been reported.This multicenter study aimed to describe the clinical characteristics and therapeutic outcomes of arthritis secondary to meningococcal infection.We performed a 5-year retrospective study. We included all patients with inflammatory joint symptoms and proven meningococcal disease defined by the identification of Neisseria meningitidis in blood, cerebrospinal fluid, or synovial fluid...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722345/anti-markovnikov-hydrofunctionalization-of-alkenes-use-of-a-benzyl-group-as-a-traceless-redox-active-hydrogen-donor
#6
Geoffroy Hervé Lonca, Derek Yiren Ong, Thi Mai Huong Tran, Ciputra Tejo, Shunsuke Chiba, Fabien Gagosz
A protocol for the anti-Markovnikov hydrofunctionalization of alkenes, that utilizes a benzyl group as a traceless redox-active hydrogen donor, has been developed. Under copper catalysis and in the presence of CF3- or N3-containing hypervalent iodine reagents, a series of homoallylic alcohol derivatives could be regioselectivity hydrofunctionalized. A similar principle was also applied to the hydrofunctionalization of alkenols.
July 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28721847/classical-scrapie-transmission-in-arr-arr-genotype-sheep
#7
Caroline Lacroux, Hervé Cassard, Hugh Simmons, Jean Yves Douet, Fabien Corbière, Severine Lugan, Pierette Costes, Naima Aron, Alvina Huor, Cécile Tillier, Francois Schelcher, Olivier Andreoletti
The ARR allele is considered to provide a very strong resistance against classical scrapie infection in sheep. In this study, we report the occurrence of clinical transmissible spongiform encephalopathy in ARR/ARR sheep, following their inoculation by the intracerebral route with a classical scrapie isolate. On first passage, the disease displayed an incomplete attack rate transmission, with incubation periods exceeding 6 years. On second passage, the obtained prion did not display better abilities to propagate than the original isolate...
July 18, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28716794/incidence-of-live-attenuated-influenza-vaccine-administration-beyond-expiry-date-in-children-and-adolescents-aged-2-17-years-in-the-uk-a-population-based-cohort-study
#8
Herve Caspard, Robert P Wise, Amy Steffey, Robert S Brody
OBJECTIVES: To estimate the proportion of live-attenuated influenza vaccine (LAIV) doses administered beyond expiry date in children and adolescents during influenza seasons 2013-2014 and 2014-2015 in the UK. DESIGN: This was a retrospective cohort study. Two cohorts of children and adolescents who received LAIV from 1 September 2013 to 31 March 2014 and from 1 September 2014 to 31 March 2015 and aged 2-17 years at time of LAIV administration were identified from the Clinical Practice Research Datalink (CPRD)...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28716741/inferring-the-shallow-phylogeny-of-true-salamanders-salamandra-by-multiple-phylogenomic-approaches
#9
Ariel Rodríguez, James D Burgon, Mariana Lyra, Iker Irisarri, Denis Baurain, Leon Blaustein, Bayram Göcmen, Sven Künzel, Barbara Mable, Arne W Nolte, Michael Veith, Sebastian Steinfartz, Kathryn R Elmer, Hervé Philippe, Miguel Vences
The rise of high-throughput sequencing techniques provides the unprecedented opportunity to analyse controversial phylogenetic relationships in great depth, but also introduce the risk of being misinterpreted by high node support values influenced by unevenly distributed missing data or unrealistic model assumptions. Here, we use three largely independent phylogenomic data sets to reconstruct the controversial phylogeny of true salamanders of the genus Salamandra. a group of amphibians providing an intriguing model to study the evolution of aposematism and viviparity...
July 14, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28716637/update-on-the-management-of-abnormal-uterine-bleeding
#10
Yael Levy-Zauberman, Anne-Gaëlle Pourcelot, Perrine Capmas, Hervé Fernandez
Abnormal uterine bleeding (AUB) is a common complaint that affects large numbers of women from puberty to menopause. It negatively affects health by causing anemia, and impacts the quality of life of women affected. AUB also has an economic impact for both women and society. Therefore, it should not be under- or overestimate and diagnosis, investigations and treatment should be proposed, taking into account the scientific data available in the current state of medical knowledge. Using the new terminology and etiologic classification of AUB is essential to communicate properly around the subject...
July 14, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28714480/the-impact-of-replication-stress-on-replication-dynamics-and-dna-damage-in-vertebrate-cells
#11
REVIEW
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas, Michelle Debatisse
The interplay between replication stress and the S phase checkpoint is a key determinant of genome maintenance, and has a major impact on human diseases, notably, tumour initiation and progression. Recent studies have yielded insights into sequence-dependent and sequence-independent sources of endogenous replication stress. These stresses result in nuclease-induced DNA damage, checkpoint activation and genome-wide replication fork slowing. Several hypotheses have been proposed to account for the mechanisms involved in this complex response...
July 17, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/28710453/intrinsic-dynamics-study-identifies-two-amino-acids-of-timp-1-critical-for-its-lrp-1-mediated-endocytosis-in-neurons
#12
Laurie Verzeaux, Nicolas Belloy, Jessica Thevenard-Devy, Jérôme Devy, Géraldine Ferracci, Laurent Martiny, Stéphane Dedieu, Manuel Dauchez, Hervé Emonard, Nicolas Etique, Emmanuelle Devarenne-Charpentier
The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated by the low-density lipoprotein receptor-related protein-1 (LRP-1). To gain insight into the interaction between TIMP-1 and LRP-1, we considered conformational changes that occur when a ligand binds to its receptor...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#13
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708305/a-novel-variant-of-dhh-in-a-familial-case-of-46-xy-disorder-of-sex-development-insights-from-molecular-dynamics-simulations
#14
Francoise Paris, Delphine Flatters, Sandrine Caburet, Bérangère Legois, Nadège Servant, Hervé Lefebvre, Charles Sultan, Reiner A Veitia
OBJECTIVE: Disorders of sex development (DSD) are a heterogeneous group of conditions affecting the differentiation and development of the internal and external genitalia. Here, we aimed at identifying the genetic cause of DSD in two 46,XY sisters from a consanguineous family. DESIGN: We performed a whole-exome sequencing of two 46,XY female individuals. Sanger sequencing was used to validate the most likely candidate variant, affecting the desert hedgehog (DHH) gene...
July 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28705649/a-new-approach-for-endoscopicneurolysis-of-the-supra-scapular-nerve-at-the-spinoglenoidnotch-a-preliminary-cadaver-study
#15
Marc-Alexandre Loirat, Maxime Tierny, Anthony Hervé, Arthur Lignel, Eric Berton, Mickaël Ropars, Hervé Thomazeau
INTRODUCTION: The suprascapular nerve (SSN) can become compressedatits 2 scapularattachments: the suprascapular and the spinoglenoid notch. The objective of this study was to describe a new arthroscopicapproach for SSN neurolysis at the spinoglenoid notch. METHOD: 10 cadaver shoulderswereused. Two weredissected to simulate the "classical" arthroscopic approach and to help in the creation of a new "direct medial retrospinal" approach. Eight othershoulders were used to validatethis new approach, with control of the whole juxta-glenoidcourse of the SSN as criterion of success...
July 10, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28705563/la-transition-enfant-adulte-pour-les-patients-souffrant-de-troubles-des-conduites-alimentaires
#16
Corinne Blanchet-Collet, Hervé Lefevre, Marie Rose Moro
THE CHILD-ADULT TRANSITION FOR PATIENTS SUFFERING FROM EATING DISORDERS.: Eating disorders are chronic and evolutive psychiatric conditions which develop on a continuum between childhood and adulthood. The transition between child, adolescent and then adult care is a period of great vulnerability which may induce drop-out and aggravation of symptoms. In the case of eating disorders in particular, personalised transition programmes have been implemented in order to provide this support.
July 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28705318/progressive-atrial-conduction-defects-associated-with-bone-malformation-caused-by-a-connexin-45-mutation
#17
Akiko Seki, Taisuke Ishikawa, Xavier Daumy, Hiroyuki Mishima, Julien Barc, Ryo Sasaki, Kiyomasa Nishii, Kayoko Saito, Mari Urano, Seiko Ohno, Saki Otsuki, Hiroki Kimoto, Alban-Elouen Baruteau, Aurelie Thollet, Swanny Fouchard, Stéphanie Bonnaud, Philippe Parent, Yosaburo Shibata, Jean-Philippe Perrin, Hervé Le Marec, Nobuhisa Hagiwara, Sandra Mercier, Minoru Horie, Vincent Probst, Koh-Ichiro Yoshiura, Richard Redon, Jean-Jacques Schott, Naomasa Makita
BACKGROUND: Inherited cardiac conduction disease is a rare bradyarrhythmia associated with mutations in various genes that affect action potential propagation. It is often characterized by isolated conduction disturbance of the His-Purkinje system, but it is rarely described as a syndromic form. OBJECTIVES: The authors sought to identify the genetic defect in families with a novel bradyarrhythmia syndrome associated with bone malformation. METHODS: The authors genetically screened 15 European cases with genotype-negative de novo atrioventricular (AV) block and their parents by trio whole-exome sequencing, plus 31 Japanese cases with genotype-negative familial AV block or sick sinus syndrome by targeted exon sequencing of 457 susceptibility genes...
July 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28703098/surveillance-perspective-on-lyme-borreliosis-across-the-european-union-and-european-economic-area
#18
Cees C van den Wijngaard, Agnetha Hofhuis, Mariana Simões, Ente Rood, Wilfrid van Pelt, Herve Zeller, Wim Van Bortel
Lyme borreliosis (LB) is the most prevalent tick-borne disease in Europe. Erythema migrans (EM), an early, localised skin rash, is its most common presentation. Dissemination of the bacteria can lead to more severe manifestations including skin, neurological, cardiac, musculoskeletal and ocular manifestations. Comparison of LB incidence rates in the European Union (EU)/European Economic Area (EEA) and Balkan countries are difficult in the absence of standardised surveillance and reporting procedures. We explored six surveillance scenarios for LB surveillance in the EU/EEA, based on the following key indicators: (i) erythema migrans, (ii) neuroborreliosis, (iii) all human LB manifestations, (iv) seroprevalence, (v) tick bites, and (vi) infected ticks and reservoir hosts...
July 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28702001/metschnikowia-pulcherrima-influences-the-expression-of-genes-involved-in-pdh-bypass-and-glyceropyruvic-fermentation-in-saccharomyces-cerevisiae
#19
Mohand Sadoudi, Sandrine Rousseaux, Vanessa David, Hervé Alexandre, Raphaëlle Tourdot-Maréchal
Previous studies reported that the use of Metschnikowia pulcherrima in sequential culture fermentation with Saccharomyces cerevisiae mainly induced a reduction of volatile acidity in wine. The impact of the presence of this yeast on the metabolic pathway involved in pyruvate dehydrogenase (PDH) bypass and glycerol production in S. cerevisiae has never been investigated. In this work, we compared acetic acid and glycerol production kinetics between pure S. cerevisiae culture and its sequential culture with M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28701367/a-fdg-pet-driven-consolidation-strategy-in-diffuse-large-b-cell-lymphoma-final-results-of-a-randomized-phase-ii-study
#20
Rene-Olivier Casasnovas, Loic Ysebaert, Catherine Thieblemont, Emmanuel Bachy, Pierre Feugier, Alain Delmer, Sabine Tricot, Jean Gabarre, Marc Andre, Christophe Fruchart, Nicolas Mounier, Richard Delarue, Michel Meignan, Alina Berriolo-Riedinger, Stephane Bardet, Jean-Francois Emile, Jean-Philippe Jais, Corinne Haioun, Herve Tilly, Franck Morschhauser
Dose-dense induction and upfront consolidation with autologous stem cell transplantation (ASCT) remain controversial issues when treating high-risk diffuse large B cell lymphoma patients. GELA designed a randomized phase II trial evaluating the efficacy of either R-ACVBP or R-CHOP14 induction and a PET-driven ASCT or standard immunochemotherapy (SIC) consolidation in aaIPI2-3 patients. PET was done at baseline, after 2 (PET2) and 4 induction cycles (PET4) and centrally assessed using international harmonization project (IHP) criteria...
July 12, 2017: Blood
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