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https://www.readbyqxmd.com/read/28093926/oestradiol-treatment-for-mood-stabilisation-in-borderline-personality-disorder
#1
Jasmin Grigg, Caroline Thew, Jayashri Kulkarni
No abstract text is available yet for this article.
January 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28067781/gestational-zearalenone-exposure-causes-reproductive-and-developmental-toxicity-in-pregnant-rats-and-female-offspring
#2
Xin Gao, Lvhui Sun, Niya Zhang, Chong Li, Jiacai Zhang, Zhuohui Xiao, Desheng Qi
Zearalenone (ZEN) is an oestrogenic mycotoxin commonly found in food and feed products and can affect reproduction and development in both humans and animals. This study aimed to determine the toxic effects of ZEN on maternal SD rats and the F1 female offspring. Sixty-four pregnant rats were divided into 4 groups and exposed to feed contaminated with ZEN (0, 5, 10, and 20 mg/kg feed) on gestational days (GDs) 0-21. Compared with the controls, the groups exposed to 10 and 20 mg/kg ZEN showed significantly decreased feed intake and body weight of pregnant rats and/or female offspring...
January 5, 2017: Toxins
https://www.readbyqxmd.com/read/28039834/disruption-of-sex-hormone-levels-and-steroidogenic-related-gene-expression-on-mongolia-racerunner-eremias-argus-after-exposure-to-triadimefon-and-its-enantiomers
#3
Jitong Li, Jing Chang, Wei Li, Baoyuan Guo, Jianzhong Li, Huili Wang
Triadimefon (TF) is a widely used chiral fungicide with one chiral centre and two enantiomers (TF1 and TF2). However, little is reported about the ecological toxicity of reptiles on an enantioselective level. TF is a potential endocrine disruptor that may interfere with sex steroid hormones, such as testosterone (T) and 17beta-estradiol (E2). In our study, the lizards Mongolia Racerunner (Eremias argus) were orally exposed to TF and its enantiomers for 21 days. Plasma sex steroid hormones and steroidogenic-related genes, including 17-beta-hydroxysteroid (hsd17β), cytochrome P450 enzymes (cyp19 and cyp17), and steroid hormone receptors (erα and Ar) were evaluated...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28018218/protective-effects-of-pleurotus-tuber-regium-on-carbon-tetrachloride-induced-testicular-injury-in-sprague-dawley-rats
#4
Kenneth O Okolo, Iyeopu M Siminialayi, Orish E Orisakwe
The high rate of male infertility and the meager resources to manage same in sub Saharan Africa have necessitated the search for cost effective and available alternatives. Mushrooms have been used traditionally in folk medicine and as nutraceuticals. This study has investigated the effect of the wild mushroom Pleurotus tuber-regium on carbon tetrachloride (CCl4) deleterious effects on the reproductive system of male rats. Thirty six rats were divided into six groups of six animals each. Group I (negative control) received 10 ml/kg olive oil intraperitoneal weekly in addition to feed and water ad libitum...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28017339/malignant-oestrogen-producing-teratoma-in-a-cat
#5
Y Machida, M Michishita, M Wada, T Hori, E Kawakami, H Yoshimura, K Ohkusu-Tsukada, K Taya, K Takahashi
A 5-year-old female domestic shorthair cat was presented with abdominal distension and serum biochemical evaluation indicated a high concentration of oestradiol (32.81 pg/ml). Exploratory laparotomy revealed a large cystic mass in the right ovary with cystic fluid containing a high level of oestradiol (18.80 pg/ml). The tumour was composed of immature neuroectodermal tissue, mature cartilage, smooth muscle, adipose tissue and aggregated, poorly differentiated mesenchymal cells. It contained cysts of various sizes that were lined by epithelium of different types...
December 22, 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28008984/melatonin-implantation-improved-the-egg-laying-rate-and-quality-in-hens-past-their-peak-egg-laying-age
#6
Yaxiong Jia, Minghui Yang, Kuanfeng Zhu, Liang Wang, Yukun Song, Jing Wang, Wenxiang Qin, Zhiyuan Xu, Yu Chen, Guoshi Liu
The egg-laying rates of hens approximately 470 days of age exhibited a positive correlation to blood melatonin levels. The hens with an egg-laying rate <30%, 30~90% and ≥90% had blood melatonin levels of 5.8 ± 2.6, 74.0 ± 32.9 and 445.9 ± 115.3 ng/ml, respectively. When 10 mg of melatonin was implanted into the hens at 300, 360, 470 and 550 days of age, the egg-laying rates increased 4.63 ± 0.46%, 8.38 ± 1.45%, 4.93 ± 0.85% and 7.93 ± 0.91%, respectively, compared to that of the controls...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000947/a-potential-mechanism-associated-with-lead-induced-testicular-toxicity-in-rats
#7
M A El-Magd, K A Kahilo, N E Nasr, T Kamal, M Shukry, A A Saleh
This study was conducted to investigate the mechanism of lead (Pb)-induced testicular toxicity. We examined the impact of Pb toxicity on 17β-oestradiol (E2), oestrogen receptors (ERs) and aromatase P450 which are key factors in spermatogenesis. Treatment of rats with Pb acetate (PbAc, 50 mg/L in drinking water) significantly reduced sperm count, motility, viability and increased sperm abnormalities along with degenerative changes in seminiferous tubules and Leydig cells. Additionally, administration of PbAc resulted in a significant reduction in serum testosterone, serum and testicular E2 as well as increased level of testicular testosterone...
December 21, 2016: Andrologia
https://www.readbyqxmd.com/read/27997335/intrafollicular-oestradiol-production-expression-of-the-lh-receptor-lhr-gene-and-its-isoforms-and-early-follicular-deviation-in-bos-indicus
#8
S Wohlres-Viana, E K N Arashiro, M A Machado, L S A Camargo, L G B Siqueira, M P Palhao, J H M Viana
The aim of the present study was to characterise the roles of intrafollicular oestradiol production and granulosa cell (GC) expression of the LH receptor (LHR) gene and its isoforms during follicular deviation in Bos indicus. Follicular wave emergence was synchronised in heifers from a Bos taurus dairy (Holstein; n=10) and a B. indicus dairy breed (Gir; n=10). Follicles were aspirated individually at sizes corresponding to the periods of predeviation, deviation and postdeviation. Intrafollicular oestradiol (IF-E2) and progesterone (IF-P4) concentrations were determined in the follicular fluid (FF) by radioimmunoassay, and relative expression of P450 aromatase (CYP19A1) and LHR forms was evaluated in GC using real-time quantitative-polymerase chain reaction...
December 21, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27993100/bisphenol-a-influences-oestrogen-and-thyroid-hormone-regulated-thyroid-hormone-receptor-expression-in-rat-cerebellar-cell-culture
#9
Virág Somogyi, Tamás L Horváth, István Tóth, Tibor Bartha, László Vilmos Frenyó, Dávid Sándor Kiss, Gergely Jócsák, Annamária Kerti, Frederick Naftolin, Attila Zsarnovszky
Thyroid hormones (THs) and oestrogens are crucial in the regulation of cerebellar development. TH receptors (TRs) mediate these hormone effects and are regulated by both hormone families. We reported earlier that THs and oestradiol (E2) determine TR levels in cerebellar cell culture. Here we demonstrate the effects of low concentrations (10(-10) M) of the endocrine disruptor (ED) bisphenol A (BPA) on the hormonal (THs, E2) regulation of TRα,β in rat cerebellar cell culture. Primary cerebellar cell cultures, glia-containing and glia-destroyed, were treated with BPA or a combination of BPA and E2 and/or THs...
December 2016: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/27981512/reduced-serum-levels-of-oestradiol-and-brain-derived-neurotrophic-factor-in-both-diabetic-women-and-hfd-feeding-female-mice
#10
Yi Zhang, Shan-Wen Zhang, Neeta Khandekar, Shi-Fei Tong, He-Qin Yang, Wan-Ru Wang, Xu-Feng Huang, Zhi-Yuan Song, Shu Lin
The estrogen levels in the pre and post menstrual phases interact with brain-derived neurotrophic factor in a complex manner, which influences the overall state of the body. To study the role of oestradiol and brain-derived neurotrophic factor in modulating obesity related type 2 diabetes and the interactions between two factors, we enrolled 15 diabetic premenopausal women and 15 diabetic postmenopausal women respectively, the same number of healthy pre and postmenopausal women were recruited as two control groups...
December 16, 2016: Endocrine
https://www.readbyqxmd.com/read/27973745/association-between-changes-in-oestradiol-and-follicle-stimulating-hormone-levels-during-the-menopausal-transition-and-risk-of-diabetes
#11
S K Park, S D Harlow, H Zheng, C Karvonen-Gutierrez, R C Thurston, K Ruppert, I Janssen, J F Randolph
AIM: To investigate the association between changes in oestradiol and follicle-stimulating hormone levels during the menopausal transition and incident diabetes. METHODS: We followed 1407 pre-menopausal women, aged 42-52 years at baseline, who experienced natural menopause, from baseline to the 12(th) annual follow-up visit in the Study of Women's Health Across the Nation (SWAN). Diabetes was defined based on fasting glucose level, medication use and self-report of physician diagnosis...
December 14, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27927075/soy-isoflavones-exert-beneficial-effects-on-letrozole-induced-rat-polycystic-ovary-syndrome-pcos-model-through-anti-androgenic-mechanism
#12
Ravi Kumar Rajan, Siva Selva Kumar M, Bhaskar Balaji
CONTEXT: Soy is the main source of phytoestrogens, which has long been used as traditional food. One major subtype of phytoestrogens includes isoflavones and they are scientifically validated for their beneficial actions on many hormone-dependent conditions. OBJECTIVE: The present study examines the effect of soy isoflavones on letrozole-induced polycystic ovary syndrome (PCOS) rat model. MATERIALS AND METHODS: PCOS was induced in Sprague-Dawley rats with of 1 mg/kg letrozole, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27899085/oestradiol-levels-and-superoxide-dismutase-activity-in-age-related-cataract-a-case-control-study
#13
Dragana Škiljić, Staffan Nilsson, Anne Petersen, Jan-Olof Karlsson, Anders Behndig, Lada Kalaboukhova, Madeleine Zetterberg
BACKGROUND: It has been suggested that the higher prevalence of cataract in women is caused by a withdrawal effect of oestrogen at menopause. In vitro studies have demonstrated protection of serum oestradiol (E2) against oxidative stress through upregulation of antioxidant enzymes, including superoxide dismutase (SOD). The purpose of the present study was to investigate E2 levels and SOD erythrocyte activity in patients with age-related cataract. METHODS: The studied subjects consisted of 103 patients with age-related cataract and 22 controls...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27898110/associations-of-blood-lead-levels-with-reproductive-hormone-levels-in-men-and-postmenopausal-women-results-from-the-spect-china-study
#14
Chi Chen, Ningjian Wang, Hualing Zhai, Xiaomin Nie, Honglin Sun, Bing Han, Qin Li, Yi Chen, Jing Cheng, Fangzhen Xia, Li Zhao, Yanjun Zheng, Zhoujun Shen, Yingli Lu
We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin(SHBG) levels were measured. The results showed that median values (interquartile range) of BLLs were 44.00 μg/L (29...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894940/changes-in-the-mrna-expression-of-structural-proteins-hormone-synthesis-and-secretion-from-bovine-placentome-sections-after-ddt-and-dde-treatment
#15
A Wojciechowska, J Mlynarczuk, J Kotwica
Disorders in the barrier function and secretory activity of the placenta can be caused by xenobiotics (XB) present in the environment and their accumulation in tissues of living organisms. Thus, the aim of this study was to investigate the effect of 1,1,1-trichloro-2,2,-bis-4-chlorophenyl-ethane (DDT) and its metabolite 1,1-dichloro-2,2-bis-4-chlorophenyl-ethene (DDE) (for 24 or 48h) at doses of 1, 10 or 100ng/ml on the function of cow placentome sections in the second trimester of pregnancy. DDT and DDE affected neither (P>0...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27883324/hormone-therapy-reduces-bone-resorption-but-not-bone-formation-in-postmenopausal-athletes
#16
Suzy Y Honisett, David Pagliaro, Kathy Tangalakis, Bronwyn Kingwell, Peter Ebeling, Robyn Craven, Juliana Antonopillai, Vasso Apostolopoulos, Lily Stojanovska
INTRODUCTION: Independently, hormone therapy and exercise have well-established protective effects on bone parameters. The combined effects of hormone therapy and exercise, however, are less clear. We, therefore, examined the effects of hormone therapy on bone turnover markers in postmenopausal women undergoing regular high intensity exercise. METHODS: In a randomised, double blind study, postmenopausal athletes competing at Masters level, received either hormone therapy (50 μg transdermal oestradiol, 5 mg MPA, n = 8) or placebo (n = 7) for 20 weeks...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27862950/region-specific-effects-of-oestradiol-on-adipose-derived-stem-cell-differentiation-in-post-menopausal-women
#17
Kimberly A Cox-York, Christopher B Erickson, Rocio I Pereira, Daniel H Bessesen, Rachael E Van Pelt
The goal of this study was to determine the effect of acute transdermal 17β-oestradiol (E2 ) on the adipogenic potential of subcutaneous adipose-derived stem cells (ASC) in post-menopausal women. Post-menopausal women (n = 11; mean age 57 ± 4.5 years) were treated for 2 weeks, in a randomized, cross-over design, with transdermal E2 (0.15 mg) or placebo patches. Biopsies of abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) were obtained after each treatment and mature adipocytes were analysed for cell size and ASC for their capacity for proliferation (growth rate), differentiation (triglyceride accumulation) and susceptibility to tumour necrosis factor alpha-induced apoptosis...
November 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27856396/oestrogens-prolactin-hypothalamic-pituitary-gonadal-axis-and-schizophrenic-psychoses
#18
REVIEW
Anita Riecher-Rössler
Interest is growing in the potential effect of gonadal hormones, prolactin, and the hypothalamic-pituitary-gonadal axis in schizophrenic psychoses. Many studies from clinical, epidemiological, and fundamental research have confirmed that oestradiol, the main component of oestrogens, can have protective effects in schizophrenic psychoses. Furthermore, many patients with schizophrenic psychoses-even in the untreated prodromal stages-have hyperprolactinaemia and gonadal dysfunction, with oestrogen deficiency in women and testosterone deficiency in men...
January 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/27856395/why-are-women-so-vulnerable-to-anxiety-trauma-related-and-stress-related-disorders-the-potential-role-of-sex-hormones
#19
REVIEW
Sophie H Li, Bronwyn M Graham
Increased prevalence, severity, and burden of anxiety, trauma-related and stress-related disorders in women compared with men has been well documented. Evidence from a variety of fields has emerged suggesting that sex hormones, particularly oestradiol and progesterone, play a significant part in generation of these sex differences. In this Series paper, we aim to integrate the literature reporting on the effects of sex hormones on biological, behavioural, and cognitive pathways, to propose two broad mechanisms by which oestradiol and progesterone influence sex differences in anxiety disorders: augmentation of vulnerability factors associated with anxiety disorder development; and facilitation of the maintenance of anxious symptoms post-development...
January 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/27832828/influence-of-the-inflammatory-status-of-entire-male-pigs-on-their-pubertal-development-and-fat-androstenone
#20
S P Parois, A Faoüen, N Le Floc'h, A Prunier
Androstenone production increases during pubertal development and plays a major role in boar taint. The objective of the present study was to evaluate the effect of a subclinical inflammation on the pubertal development of boars and hence on fat androstenone. Contrasted hygiene conditions were applied during rearing to increase the variability of the inflammatory status. Boars from a commercial cross line were allocated at 139±0.9 days of age (Day 0) and 81.3±5.9 kg of live weight either to Good (n=61) or Poor (n=54) hygiene conditions until slaughter at 172...
November 11, 2016: Animal: An International Journal of Animal Bioscience
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