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https://www.readbyqxmd.com/read/29790806/bisphenol-s-modulates-concentrations-of-bisphenol-a-and-oestradiol-in-female-and-male-mice
#1
Tyler Pollock, Lucas J Greville, Rachel E Weaver, Marija Radenovic, Denys deCatanzaro
1. Concern over endocrine-disrupting actions of bisphenol A (BPA) has prompted some manufacturers to remove it from consumer products. Among the chemical replacements in 'BPA-free' products are other bisphenol analogues, such as bisphenol S (BPS). Given evidence that BPA and BPS possess similar oestrogenic activity, their capacity to interact and disrupt oestrogen homeostasis should be examined. 2. We investigated whether BPS can modulate concentrations of 14 C-BPA, exogenous 3 H-oestradiol (E2), or natural E2...
May 23, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29782684/intelligent-mesoporous-materials-for-selective-adsorption-and-mechanical-release-of-organic-pollutants-from-water
#2
Siying Xie, Shanshan Wu, Sihan Bao, Yanqiu Wang, Yongtai Zheng, Danfeng Deng, Liping Huang, Lingling Zhang, Myongsoo Lee, Zhegang Huang
Despite recent advances in the porous materials for efficient removal of dissolved organic pollutants from water, the regeneration of porous characteristics for reuse with preventing secondary contamination remains a challenge. Here, novel supramolecular absorbents with hydrophobic pore are prepared by the self-assembly of propeller-shaped aromatic amphiphiles. The assembly of folded propeller provides a mesoporous environment within aromatic segments, which is suitable for the removal of organic pollutants from waste water...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29778102/effects-of-extending-the-length-of-pro-oestrus-in-an-oestradiol-and-progesterone-based-oestrus-synchronisation-program-on-ovarian-function-uterine-environment-and-pregnancy-establishment-in-beef-heifers
#3
J J de la Mata, R Núñez-Olivera, F Cuadro, D Bosolasco, V de Brun, A Meikle, G A Bó, A Menchaca
The aim of the present study was to investigate the effects of a strategy for extending pro-oestrus (the interval between luteolysis and ovulation) in an oestrus synchronisation protocol (named J-Synch) in beef heifers on follicular growth, sexual steroid concentrations, the oestrogen receptor ERα and progesterone receptors (PR) in the uterus, insulin-like growth factor (IGF) 1 and pregnancy rates. In Experiment 1, heifers treated with the new J-Synch protocol had a longer pro-oestrus period than those treated with the conventional protocol (mean (±s...
May 21, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29765691/sexual-phenotype-drives-variation-in-endocrine-responses-to-social-challenge-in-a-quasi-clonal-animal
#4
Cheng-Yu Li, Shu-Ping Huang, Mark Garcia, Adam Fuller, Yuying Hsu, Ryan L Earley
In many species, males tend to behave more aggressively than females and female aggression often occurs during particular life stages such as maternal defence of offspring. Though many studies have revealed differences in aggression between the sexes, few studies have compared the sexes in terms of their neuroendocrine responses to contest experience. We investigated sex differences in the endocrine response to social challenge using mangrove rivulus fish, Kryptolebias marmoratus . In this species, sex is determined environmentally, allowing us to produce males and hermaphrodites with identical genotypes...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29754425/effects-of-oestradiol-for-luteal-phase-support-in-fresh-embryo-transfer-cycles-a-retrospective-cohort-study
#5
Wei Zhao, Yifeng Liu, Peng Xu, Yiqing Wu, Kai Chen, Xiaoyan Guo, Fan Zhang, Yun Huang, Linlin Zhu, Runjv Zhang, Dan Zhang
OBJECTIVE: Any benefit of oestradiol supplementation with progesterone for luteal support after fresh embryo transfer in in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) cycles remains controversial. In this study, we further addressed this question in cycles using gonadotropin-releasing hormone (GnRH) agonist for ovarian stimulation. DESIGN: A retrospective cohort study in a tertiary teaching and research hospital. PATIENT(S): A total of 1602 patients were given oestradiol valerate (E) in addition to progesterone(P) as luteal support...
May 12, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#6
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29723157/testosterone-and-dihydrotestosterone-reduce-platelet-activation-and-reactivity-in-older-men-and-women
#7
Kamil Karolczak, Lucyna Konieczna, Tomasz Kostka, Piotr J Witas, Bartlomiej Soltysik, Tomasz Baczek, Cezary Watala
The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no ex vivo studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets - one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation (surface membrane expression of GPII/IIIa complex and P-selectin) and platelet reactivity in response to arachidonate, collagen or ADP, monitored with whole blood aggregometry and flow cytometry...
May 2, 2018: Aging
https://www.readbyqxmd.com/read/29720397/increased-long-qt-and-torsade-de-pointes-reporting-on-tamoxifen-compared-with-aromatase-inhibitors
#8
Virginie Grouthier, Benedicte Lebrun-Vignes, Andrew M Glazer, Philippe Touraine, Christian Funck-Brentano, Antoine Pariente, Carine Courtillot, Anne Bachelot, Dan M Roden, Javid J Moslehi, Joe-Elie Salem
OBJECTIVE: A prolonged QTc (LQT) is a surrogate for the risk of torsade de pointes (TdP). QTc interval duration is influenced by sex hormones: oestradiol prolongs and testosterone shortens QTc. Drugs used in the treatment of breast cancer have divergent effects on hormonal status. METHODS: We performed a disproportionality analysis using the European database of suspected adverse drug reaction (ADR) reports to evaluate the reporting OR (ROR χ2 ) of LQT, TdP and ventricular arrhythmias associated with selective oestrogen receptor modulators (SERMs: tamoxifen and toremifene) as opposed to aromatase inhibitors (AIs: anastrozole, exemestane and letrozole)...
May 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29720337/insulin-promotes-preantral-follicle-growth-and-antrum-formation-through-temporal-expression-of-genes-regulating-steroidogenesis-and-water-transport-in-the-cat
#9
Chommanart Thongkittidilok, Ram Pratap Singh, Pierre Comizzoli, David Wildt, Nucharin Songsasen
The aims of the present study were to determine the effects of insulin, invitro, on: (1) the viability and growth of domestic cat ovarian follicles; (2) mRNA expression of genes regulating steroidogenesis (cytochrome P450 family 17 subfamily, A polypeptide 1 (Cyp17a1), cytochrome P450 family 19 subfamily, A polypeptide 1 (Cyp19a1) and steroidogenic acute regulatory protein (Star)) and water transport (aquaporins (AQPs) Aqp1, Aqp3, Aqp7, Aqp9); and (3) steroid production (17β-oestradiol (E2), progesterone (P4), androstenedione (A4))...
May 3, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29705296/glyphosate-affects-the-secretion-of-regulators-of-uterine-contractions-in-cows-while-it-does-not-directly-impair-the-motoric-function-of-myometrium-in-vitro
#10
Wrobel Michael Hubert
The effects of pure glyphosate and its most popular product (brand name: Roundup) on the secretion of hormones involved in the regulation of myometrial contractions as well as their direct effects on myometrial contractions were examined. Myometrial strips as well as uterine and ovarian cells were taken from cows during the oestrous cycle and they were treated with both compounds at concentrations from their environmental range. Glyphosate stimulated the secretion of oestradiol from granulosa cells while both herbicides increased and decreased oxytocin (OT) and progesterone secretion from luteal cells respectively...
April 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29680774/targeting-hypothalamic-pituitary-adrenal-axis-hormones-and-sex-steroids-for-improving-cognition-in-major-mood-disorders-and-schizophrenia-a-systematic-review-and-narrative-synthesis
#11
REVIEW
Virginia Soria, Alexandre González-Rodríguez, Elena Huerta-Ramos, Judith Usall, Jesús Cobo, Miquel Bioque, Juan David Barbero, Clemente García-Rizo, Meritxell Tost, José Antonio Monreal, Javier Labad
Cognitive deficits are a core feature of serious mental illnesses such as schizophrenia, major depressive disorder (MDD) and bipolar disorder (BD) and are a common cause of functional disability. There is limited efficacy of pharmacological interventions for improving the cognitive deficits in these disorders. As pro-cognitive pharmacological treatments are lacking, hormones or drugs that target the endocrine system may become potential candidates for 'repurposing' trials aiming to improve cognition. We aimed to study whether treatment with drugs targeting the hypothalamic-pituitary-adrenal (HPA) axis and sex steroids can improve cognition in patients with schizophrenia, MDD or BD...
April 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29673411/dietary-minerals-reproductive-hormone-levels-and-sporadic-anovulation-associations-in-healthy-women-with-regular-menstrual-cycles
#12
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Karen C Schliep, Torie C Plowden, Ellen N Chaljub, Sunni L Mumford
Although minerals are linked to several reproductive outcomes, it is unknown whether dietary minerals are associated with ovulatory function. We hypothesised that low intakes of minerals would be associated with an increased risk of anovulation. We investigated associations between dietary mineral intake and both reproductive hormones and anovulation in healthy women in the BioCycle Study, which prospectively followed up 259 regularly menstruating women aged 18-44 years who were not taking mineral supplements for two menstrual cycles...
April 20, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29628021/regulation-by-3-5-3-tri-iodothyronine-and-fsh-of-cytochrome-p450-family-19-cyp19-expression-in-mouse-granulosa-cells
#13
Juan Liu, Yingying Han, Ye Tian, Xuechun Weng, Xusong Hu, Wenbo Liu, Dai Heng, Kaili Xu, Yanzhou Yang, Cheng Zhang
Cytochrome P450 family 19 (CYP19) plays an important role in follicular development, which is regulated by FSH. Although 3,5,3'-tri-iodothyronine (T3) combines with FSH to induce preantral follicle growth and granulosa cell development, the mechanism involved remains unclear. The aim of the present study was to determine the cellular and molecular mechanisms by which thyroid hormone (TH) and FSH regulate CYP19 expression and sterol biosynthesis during preantral follicle growth. Mice were injected subcutaneously (s...
April 9, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29620427/blocking-oestradiol-synthesis-pathways-with-potent-and-selective-coumarin-derivatives
#14
Sanna Niinivehmas, Pekka A Postila, Sanna Rauhamäki, Elangovan Manivannan, Sami Kortet, Mira Ahinko, Pasi Huuskonen, Niina Nyberg, Pasi Koskimies, Sakari Lätti, Elina Multamäki, Risto O Juvonen, Hannu Raunio, Markku Pasanen, Juhani Huuskonen, Olli T Pentikäinen
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HSD1 inhibition at 5 µM and, furthermore, three of them produced ≥68% inhibition at 1 µM. A docking-based structure-activity relationship analysis was done to determine the molecular basis of the inhibition and the cross-reactivity of the analogues was tested against oestrogen receptor, aromatase, cytochrome P450 1A2, and monoamine oxidases...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29611653/the-evaluation-of-blood-concentrations-of-testosterone-17%C3%AE-oestradiol-and-anti-mu%C3%A2-llerian-hormone-in-dogs-with-cryptorchidism-and-testicular-tumours
#15
L Hornakova, T Vrbovska, M Pavl'ak, A Valencakova-Agyagosova, M Halo, J Hajurka
Cryptorchidism and testicular tumours are very common disorders in dogs genitalia. The aim of the present study was o obtain an overview of serum 17β-oestradiol, anti-Muellerian hormone (AMH) and testosterone levels in intact dogs compared to dogs with different testicular tumours and dogs with cryptorchidism. Testosterone, AMH and 17β-oestradiol concentrations were measured in peripheral and local spermatic venous blood in dogs with unilateral cryptorchidism (n=8), dogs with neoplastic testicular diseases (n=8) and in a control group of mature intact dogs (n=8)...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29547878/the-effect-of-metabolic-syndrome-on-male-reproductive-health-a-cross-sectional-study-in-a-group-of-fertile-men-and-male-partners-of-infertile-couples
#16
Kristel Ehala-Aleksejev, Margus Punab
This study aimed to determine the effect of metabolic syndrome (MS) on the reproductive function in fertile (FM) and male partners of infertile couples (MPIC). We performed a cross-sectional study formatting two study groups: partners of pregnant women (n = 238; mean age 32.0) as FM and male partners of infertile couples (n = 2642; mean age 32.6) as MPIC. A standard semen analysis was performed and clinical, laboratory and lifestyle data were analysed. The adapted NCEP-ATPIII criteria were used to define MS...
2018: PloS One
https://www.readbyqxmd.com/read/29543369/neuroanatomical-connections-between-kisspeptin-neurones-and-somatostatin-neurones-in-female-and-male-rat-hypothalamus-a-possible-involvement-of-sstr1-in-kisspeptin-release
#17
Laurence Dufourny, Oona Delmas, Ana-Paula Teixeira-Gomes, Caroline Decourt, Joanna H Sliwowska
Somatostatin (SST) a neuropeptide involved in the central modulation of several physiological functions, is co-distributed in the same hypothalamic areas as kisspeptin (KP), the most potent secretagogue of the gonadotropin-releasing hormone (GnRH) secretion known to date. As SST infused intracerebroventricularly (icv) evoked a potent inhibition of GnRH release, we explored neuroanatomical relationships between KP and SST populations in male and female rats. For that, intact males and ovariectomised oestradiol-replaced females were killed and their brains processed in order to simultaneously detect KP, SST and synapsin, a marker for synapses...
March 15, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29537325/a-comparison-of-two-different-oral-contraceptives-in-patients-with-severe-primary-dysmenorrhoea
#18
Gulsum Uysal, Hatice Akkaya, Fulya Cagli, Sadan Tutus, Ahter T Tayyar
Pain relief of two different oral contraceptive pills (OCPs) in severe primary dysmenorrhoea (PD) was compared. Sixty-six nulliparous patients with severe PD requiring contraception were evaluated. Group 1 comprised 33 healthy controls. Patients with severe PD were divided into two groups. Patients in Group 2 were administered oestradiol valerate/dienogest and patients in Group 3 were administered ethinylestradiol/drospirenone. Doppler indices of both uterine arteries (left and right) including systolic/diastolicrates (S/D), pulsatility index (PI) and resistance index (RI) were measured, and a visual analogue scale (VAS) was applied to patients before treatment...
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29537093/natural-endocrine-profiles-of-the-group-living-skunk-anemonefish-amphiprion-akallopisos-in-relation-to-their-size-based-dominance-hierarchy
#19
S C Mills, J L O'Donnell, G Bernardi, R Beldade
Group-living animals commonly display differences in behaviour, physiology and endocrine profiles between conspecifics within the group, which are tightly linked to reproduction. Teleosts exhibit a variety of social systems, where social status, as well as sex, has been linked to different androgen and oestrogen profiles. Levels of gonadal androgen and oestrogen were investigated as a function of sex and position in a social hierarchy in free-living individuals of the skunk anemonefish Amphiprion akallopisos, a protandrous pomacentrid fish with a size-based dominance hierarchical social system...
March 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29530425/medical-treatment-of-endometriosis-related-pain
#20
REVIEW
Paolo Vercellini, Laura Buggio, Maria Pina Frattaruolo, Alessandra Borghi, Dhouha Dridi, Edgardo Somigliana
Available medical treatments for symptomatic endometriosis act by inhibiting ovulation, reducing serum oestradiol levels, and suppressing uterine blood flows. For this, several drugs can be used with a similar magnitude of effect, in terms of pain relief, independently of the mechanism of action. Conversely, safety, tolerability, and cost differ. Medications for endometriosis can be categorized into low-cost drugs including oral contraceptives (OCs) and most progestogens, and high-cost drugs including dienogest and GnRH agonists...
February 15, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
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