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association of vitamin d with gestational diabetes

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https://www.readbyqxmd.com/read/29883217/association-between-vitamin-d-status-and-hyperinsulinism
#1
Catherine McCormack, Shalem Leemaqz, Denise Furness, Gustaaf Dekker, Claire Roberts
AIMS: Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes. Hyperinsulinism is also thought to increase miscarriages. We investigated the association between vitamin D levels and hyperinsulinism in a cohort of recurrent miscarriage patients. METHODS: Patients undergoing miscarriage investigations had insulin and vitamin D levels tested...
June 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29875736/deconvoluting-the-biological-roles-of-vitamin-d-binding-protein-during-pregnancy-a-both-clinical-and-theoretical-challenge
#2
REVIEW
Spyridon N Karras, Theocharis Koufakis, Hana Fakhoury, Kalliopi Kotsa
The teleological purpose of an ongoing pregnancy is to fulfill its fundamental role of a successful, uncomplicated delivery, in conjunction with an optimal intrauterine environment for the developing fetus. Vitamin D metabolism is adapted to meet both these demands during pregnancy; first by stimulation of calcium absorption for adequate intrauterine bone mineral accrual of the fetus, and second, by enhancing systemic and local maternal tolerance to paternal and fetal alloantigens. Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29850611/vitamin-d-gestational-diabetes-and-measures-of-glucose-metabolism-in-a-population-based-multiethnic-cohort
#3
Åse Ruth Eggemoen, Christin Wiegels Waage, Line Sletner, Hanne L Gulseth, Kåre I Birkeland, Anne Karen Jenum
Objective: We explored associations between maternal 25-hydroxyvitamin D (25(OH)D) status during pregnancy and gestational diabetes (GDM) and other measures of glucose metabolism. Methods: We analysed 25(OH)D at 15 and 28 gestational weeks (GW) in 745 multiethnic pregnant women attending antenatal care units in Oslo, Norway, between 2008 and 2010. GDM was diagnosed with a 75 g oral glucose tolerance test at 28 GW. Separate regression analyses were performed to investigate associations between 25(OH)D and GDM and measures of glucose metabolism...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29842806/systematic-review-and-meta-analysis-of-spanish-studies-regarding-the-association-between-maternal-25-hydroxyvitamin-d-levels-and-perinatal-outcomes
#4
Samuel J Martínez-Domínguez, Mauricio Tajada, Peter Chedraui, Faustino R Pérez-López
OBJECTIVE: This systematic review and meta-analysis of Spanish studies assessed the association of maternal 25-hydroxyvitamin D [25(OH)D] levels on perinatal outcomes. METHODS: PubMed, Cochrane Library, Embase, Scielo, Scopus, and Web of Science research databases were searched from inception through December 30 2017 using the terms 'vitamin D', 'pregnancy', and 'Spain'. Studies that compared first or second half of pregnancy normal 25(OH)D (≥30.0 ng/mL) versus insufficient (20...
May 29, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29788364/effectiveness-of-prenatal-vitamin-d-deficiency-screening-and-treatment-program-a-stratified-randomized-field-trial
#5
Maryam Rostami, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Razieh Bidhendi Yarandi, Sonia Minooee, Bruce W Hollis, Farhad Hosseinpanah
Context: Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of a routine prenatal care. Objective: We aimed at determining the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D(25(OH)D) levels and preventing pregnancy complications. Also, to identify a safe regimen, we compared several regimens in a subgroup of vitamin D deficient pregnant women...
May 18, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29783717/associations-of-maternal-vitamin-d-deficiency-with-pregnancy-and-neonatal-complications-in-developing-countries-a-systematic-review
#6
REVIEW
Paige van der Pligt, Jane Willcox, Ewa A Szymlek-Gay, Emily Murray, Anthony Worsley, Robin M Daly
Pregnant women in Asia, the Middle East, Africa and Latin America are at risk of vitamin D deficiency (VDD) and prevalence throughout these regions are among the highest, globally. Maternal VDD has been associated with increased risk of a number of adverse maternal and neonatal health outcomes, yet research from developing countries is limited. We assessed the associations of maternal VDD during pregnancy with adverse health outcomes by synthesizing the literature from observational studies conducted in developing countries...
May 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29740234/associations-of-spexin-and-cardiometabolic-parameters-among-women-with-and-without-gestational-diabetes-mellitus
#7
Nasser M Al-Daghri, Hazim A Al-Hazmi, Abdulrahman Al-Ajlan, Mohammad S Masoud, Abeer Al-Amro, Amani Al-Ghamdi, Abdullah M Alnaami, Omar S Al-Attas, Majed S Alokail
Spexin (SPX) is a novel biomarker abundantly expressed in several animal and human tissues implicated in food intake and glucose control, respectively. As new roles for SPX are emerging, the present study explored for the first time, the associations of SPX to several cardiometabolic indices and inflammatory markers in pregnant women, a demographic not yet investigated with respect to SPX. A total of 117 Saudi women subdivided to those with gestational diabetes mellitus (GDM) (N = 63) and those without (N = 54) were included in this cross-sectional study...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29690937/concentration-of-25-hydroxyvitamin-d-from-neonatal-dried-blood-spots-and-the-relation-to-gestational-age-birth-weight-and-ponderal-index-the-d-tect-study
#8
Amélie Keller, Mina N Händel, Peder Frederiksen, Ramune Jacobsen, Arieh S Cohen, John J McGrath, Berit L Heitmann
Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002...
April 25, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29674191/seasonality-of-hypertensive-disorders-of-pregnancy-a-south-australian-population-study
#9
Petra E Verburg, Gus A Dekker, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Claire T Roberts
OBJECTIVES: To investigate the seasonal variation of hypertensive disorders of pregnancy (HDP) in South Australia. STUDY DESIGN: Retrospective population study including all 107,846 liveborn singletons during 2007-2014 in South Australia. Seasonality in incidence of HDP in relation to estimated date of conception (eDoC) and date of birth (DoB) were examined using Fourier series analysis. MAIN OUTCOME MEASURES: Seasonality of HDP in relation to eDoC and DoB...
April 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29608221/maternal-vitamin-d-and-markers-of-glycaemia-during-pregnancy-in-the-belfast-centre-of-the-hyperglycaemia-and-adverse-pregnancy-outcome-study
#10
C Casey, A McGinty, V A Holmes, A J Hill, C C Patterson, I S Young, D R McCance
AIMS: To measure total 25-hydroxyvitamin D levels in women in mid-pregnancy who participated in the Belfast centre of the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) observational study, and to investigate the associations between levels of 25-hydroxyvitamin D and markers of gestational diabetes mellitus and lipid biomarkers. METHODS: A total of 1585 pregnant women had serum samples available for measurement. Participants were recruited from the Royal Jubilee Maternity Hospital, Belfast, Northern Ireland, at 24-32 weeks' gestation, as part of the HAPO study...
April 2, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29558518/risk-factors-for-type-2-diabetes-mellitus-an-exposure-wide-umbrella-review-of-meta-analyses
#11
Vanesa Bellou, Lazaros Belbasis, Ioanna Tzoulaki, Evangelos Evangelou
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a global epidemic associated with increased health expenditure, and low quality of life. Many non-genetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed. METHODS: We searched PubMed to capture all meta-analyses and Mendelian randomization studies for risk factors of T2DM. For each association, we estimated the summary effect size, its 95% confidence and prediction interval, and the I2 metric...
2018: PloS One
https://www.readbyqxmd.com/read/29523876/association-between-maternal-mid-gestation-vitamin-d-status-and-neonatal-abdominal-adiposity
#12
Mya Thway Tint, Mary F Chong, Izzuddin M Aris, Keith M Godfrey, Phaik Ling Quah, Jeevesh Kapur, Seang Mei Saw, Peter D Gluckman, Victor S Rajadurai, Fabian Yap, Michael S Kramer, Yap-Seng Chong, Christiani Jeyakumar Henry, Marielle V Fortier, Yung Seng Lee
OBJECTIVES: Lower vitamin D status has been associated with adiposity in children through adults. However, the evidence of the impact of maternal vitamin-D status during pregnancy on offspring's adiposity is mixed. The objective of this study was to examine the associations between maternal vitamin-D [25(OH)D] status at mid-gestation and neonatal abdominal adipose tissue (AAT) compartments, particularly the deep subcutaneous adipose tissue linked with metabolic risk. METHODS: Participants (N = 292) were Asian mother-neonate pairs from the mother-offspring cohort, Growing Up in Singapore Towards healthy Outcomes...
March 9, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29449829/effects-of-vitamin-d-deficiency-on-incidence-risk-of-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#13
Mansour Amraei, Safoura Mohamadpour, Kourosh Sayehmiri, Seyedeh Fatemeh Mousavi, Ehsan Shirzadpour, Ardeshir Moayeri
Introduction: Proper nutrition is important for overall health, and it reduces healthcare costs associated with malnutrition. Many studies have investigated vitamin D deficiency and its role in gestational diabetes and controversial data have reported. A comprehensive consideration of articles in this field provides the possibility of a general study of this relationship. This meta-analysis is an evaluation of the relationship between vitamin D deficiency and gestational diabetes. Material and methods: Different databases (such as PubMed, Science Information Institute, EmBase, Scopus, and the Cochrane Library) were searched for studies and eligible English articles published before February 2017 that have reported the risk of gestational diabetes in relation to vitamin D deficiency...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29447091/obesity-in-pregnancy-a-comparison-of-four-national-guidelines
#14
Dana Vitner, Kristin Harris, Cynthia Maxwell, Dan Farine
BACKGROUND: Obesity in pregnancy has become one of the most important challenges in obstetrical care given its prevalence and potential adverse impact on both mother and fetus. The primary objective of this descriptive review is to identify common themes and distinctions within the current recommendations for maternal obesity in the most updated version of four published national guidelines. METHODS: We reviewed the following guidelines for obesity in pregnancy: American College of Obstetricians and Gynecologists (ACOG) 2015, Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG) 2013, Royal College of Obstetrics and Gynecology (RCOG) 2010, and Society of Obstetrics and Gynecologists of Canada (SOGC) 2010...
February 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29402818/maternal-vitamin-d-status-and-risk-of-gestational-diabetes-a-meta-analysis
#15
Lingmin Hu, Yue Zhang, Xing Wang, Lianghui You, Pengfei Xu, Xianwei Cui, Lijun Zhu, Chenbo Ji, Xirong Guo, Juan Wen
BACKGROUND/AIMS: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. METHODS: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29388405/-vitamin-d-deficiency-during-pregnancy-what-s-the-local-situation
#16
L Vranken, P Emonts, O Bruyère, E Cavalier
Vitamin D deficiency is a worldwide health problem, also during pregnancy. Inadequate maternal vitamin D status in pregnancy is associated with poor fetal growth, impaired bone development and rickets in infants after birth. Furthermore, higher rates of preeclampsia and gestational diabetes are associated with low maternal vitamin D status during pregnancy. Toxicity of vitamin D is rare. Most countries recommend vitamin D supplementation during pregnancy but guidelines are controversial and inadequate compared to real mother's and child's needs...
January 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29321080/prenatal-vitamin-d-status-and-offspring-s-growth-adiposity-and-metabolic-health-a-systematic-review-and-meta-analysis
#17
Christina Santamaria, Wei Guang Bi, Line Leduc, Negar Tabatabaei, Prévost Jantchou, Zhong-Cheng Luo, François Audibert, Anne Monique Nuyt, Shu Qin Wei
In this systematic review and meta-analysis of observational studies, we aimed to estimate the associations between prenatal vitamin D status and offspring growth, adiposity and metabolic health. We searched the literature in human studies on prenatal vitamin D status and offspring growth in PubMed, up to July 2017. Studies were selected according to their methodological quality and outcomes of interest (anthropometry, fat mass and diabetes in offspring). The inverse variance method was used to calculate the pooled mean difference (MD) with 95 % CI for continuous outcomes, and the Mantel-Haenszel method was used to calculate the pooled OR with 95 % CI for dichotomous outcomes...
February 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29262380/vitamin-d-effects-on-human-reproduction-pregnancy-and-fetal-well-being
#18
REVIEW
E L Heyden, S J Wimalawansa
Pregnancy places exceptional demands on vitamin D and calcium availability; thus, their deficiencies during pregnancy threaten the woman and her fetus. Globally, vitamin D and other micronutrient deficiencies are common during pregnancy, especially in developing countries where pregnant women have less access to nutritional supplements. Vitamin D deficiency has been reported to be as high as 40% among pregnant women. As a pregnancy progresses, the requirements for vitamin D increase and thus, can worsen preexisting hypovitaminosis D...
December 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29246128/maternal-vitamin-d-status-gestational-diabetes-and-infant-birth-size
#19
Helena H Hauta-Alus, Heli T Viljakainen, Elisa M Holmlund-Suila, Maria Enlund-Cerullo, Jenni Rosendahl, Saara M Valkama, Otto M Helve, Timo K Hytinantti, Outi M Mäkitie, Sture Andersson
BACKGROUND: Maternal vitamin D status has been associated with both gestational diabetes mellitus (GDM) and fetal growth restriction, however, the evidence is inconsistent. In Finland, maternal vitamin D status has improved considerably due to national health policies. Our objective was to compare maternal 25-hydroxy vitamin D concentrations [25(OH)D] between mothers with and without GDM, and to investigate if an association existed between maternal vitamin D concentration and infant birth size...
December 15, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29244241/vitamin-d-and-gestational-diabetes-mellitus-a-systematic-review-based-on-data-free-of-hawthorne-effect
#20
REVIEW
Y Zhang, Y Gong, H Xue, J Xiong, G Cheng
BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly prevalent disorder, associated with low blood vitamin D level. OBJECTIVES: To evaluate the relationship between vitamin D and GDM. SEARCH STRATEGY: EMBASE, MEDLINE, Cochrane Library and China Biology Medicine disc were searched up to May 2017. The references of previous studies were screened. SELECTION CRITERIA: Observational studies on the relationship between vitamin D and GDM free from Hawthorne effect and randomised controlled trials of vitamin D supplementation during pregnancy for preventing or treating GDM were included...
June 2018: BJOG: An International Journal of Obstetrics and Gynaecology
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