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association of vitamin d with gestational diabetes

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https://www.readbyqxmd.com/read/27933507/determinants-of-maternal-vitamin%C3%A2-d-concentrations-in-slovenia-a%C3%A2-prospective-observational-study
#1
Andraž Dovnik, Faris Mujezinović, Milena Treiber, Breda Pečovnik Balon, Maksimiljan Gorenjak, Uroš Maver, Iztok Takač
OBJECTIVE: To analyze the vitamin D status of pregnant women in Slovenia and the factors influencing it. METHODS: The study was performed in Maribor University Medical Centre (location 46°N). Maternal serum 25-hydroxy-vitamin D (25(OH)D) in 4 groups of 100 pregnant women in 4 different seasons of the year was measured at the time of delivery. Data on life style, eating habits, sunbathing and intake of vitamin D supplements during pregnancy were obtained using a questionnaire...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27843556/seasonality-of-gestational-diabetes-mellitus-a-south-australian-population-study
#2
Petra E Verburg, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Gus A Dekker, Claire T Roberts
OBJECTIVE: To investigate whether there is a seasonal variation in the incidence of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: This retrospective cohort study of 60 306 eligible South Australian live-born singletons during 2007-2011 recorded in the South Australian Perinatal Statistics Collection (SAPSC) examined the incidence of GDM in relation to estimated date of conception (eDoC). Fourier series analysis was used to model seasonal trends...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27764194/vitamin-d-deficiency-increases-the-risk-of-adverse-neonatal-outcomes-in-gestational-diabetes
#3
Letícia Schwerz Weinert, Angela Jacob Reichelt, Leonardo Rauber Schmitt, Roberta Boff, Maria Lucia Rocha Oppermann, Joiza Lins Camargo, Sandra Pinho Silveiro
BACKGROUND: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. METHODS: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement...
2016: PloS One
https://www.readbyqxmd.com/read/27753425/the-relationship-between-25-hydroxyvitamin-d-concentration-in-early-pregnancy-and-pregnancy-outcomes-in-a-large-prospective-cohort
#4
Veronica T Boyle, Eric B Thorstensen, David Mourath, M Beatrix Jones, Lesley M E McCowan, Louise C Kenny, Philip N Baker
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27690002/serum-25-oh-vitamin-d-levels-in-polish-women-during-pregnancies-complicated-by-hypertensive-disorders-and-gestational-diabetes
#5
Piotr Domaracki, Pawel Sadlecki, Grazyna Odrowaz-Sypniewska, Ewa Dzikowska, Pawel Walentowicz, Joanna Siodmiak, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
BACKGROUND: An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM. MATERIAL AND METHODS: The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension (n = 45), preeclampsia (n = 23) or GDM (n = 103)...
September 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27679649/the-impact-of-vitamin-d-supplementation-on-post-partum-glucose-tolerance-and-insulin-resistance-in-gestational-diabetes-a-randomized-controlled-trial
#6
Majid Valizadeh, Zahra Piri, Farnaz Mohammadian, Koorosh Kamali, Hamid Reza Amir Moghadami
BACKGROUND: Hypovitaminosis D has been associated with the development of gestational diabetes mellitus (GDM) in many observational studies. OBJECTIVES: We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a randomized clinical trial. PATIENTS AND METHODS: Women with GDM at 12 - 32 weeks of gestation were assigned randomly to either the intervention group (in which serum 25-hydroxy vitamin D [25OHD] levels were measured immediately, n = 48) or the control group (in which the serum was stored and assayed at 6 - 12 weeks post-partum, n = 48)...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27651580/prevalence-of-vitamin-d-deficiency-in-burka-clad-pregnant-women-in-a-450-bedded-maternity-hospital-of-delhi
#7
Sangita Nangia Ajmani, Mohini Paul, Poonam Chauhan, A K Ajmani, Namrta Yadav
AIM: To assess the prevalence of vitamin D deficiency in burka-clad pregnant women and to study feto-maternal outcome in these women. METHODS: 200 pregnant burka-clad women of 18-40-year age group irrespective of the period of gestation were recruited from the ANC OPD/ward of Kasturba hospital, and their vitamin D levels were estimated. Patients were categorized into vitamin D deficient, vitamin D inadequate, and vitamin D adequate according to The Endocrine Society Guidelines...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27636996/genetic-variants-in-vitamin-d-signaling-pathways-and-risk-of-gestational-diabetes-mellitus
#8
Aiwu Shi, Juan Wen, Guangquan Liu, Heng Liu, Ziyi Fu, Jing Zhou, Yao Zhu, Yaoqiu Liu, Xirong Guo, Jianguo Xu
Vitamin D (VD) deficiency during pregnancy has been repeatedly linked to an increased gestational diabetes mellitus (GDM) risk. We sought to determine the influences of genetic variants in vitamin D signaling pathways on the risk of GDM. In this study, we genotyped 15 single nucleotide polymorphisms (SNPs) within 8 representative genes (CYP27A1, CYP27B1, CYP24A1, VDR, RXRA, RXRB, RXRG and GC) of the vitamin D signaling pathways in a case-control study with 964 GDM cases and 1,021 controls using the Sequenom MassARRAY iPLEX platform...
September 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27588106/effect-of-various-doses-of-vitamin-d-supplementation-on-pregnant-women-with-gestational-diabetes-mellitus-a-randomized-controlled-trial
#9
Qingying Zhang, Yan Cheng, Mulan He, Tingting Li, Ziwen Ma, Haidong Cheng
It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM)...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27558700/vitamin-d-and-its-impact-on-maternal-fetal-outcomes-in-pregnancy-a-critical-review
#10
Shreya Agarwal, Oormila Kovilam, Devendra K Agrawal
The role of vitamin D beyond its classical function in calcium homeostasis has been of significant interest in recent years. There has been expanding research on the pleiotropic role of vitamin D in pregnancy and the implications of its deficiency on maternal-fetal outcomes. Several studies have associated low maternal vitamin D status to adverse outcomes in pregnancy, including preeclampsia, gestational diabetes, preterm births, low birth weight, and others. Several randomized controlled clinical trials of Vitamin D supplementation during pregnancy have also been conducted...
August 24, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27424441/-maternal-serum-25-hydroxy-vitamin-d-levels-in-the-first-trimester-and-adverse-gestational-outcomes
#11
E Álvarez-Silvares, M Vilouta-Romero, E Borrajo-Hernández, M L Morales-Serrano, M T Alves-Pérez
BACKGROUND: Some disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today. OBJECTIVE: The aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction. MATERIAL AND METHOD: We conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N)...
March 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27221615/impact-of-vitamin-d-deficiency-on-maternal-and-birth-outcomes-in-the-saudi-population-a-cross-sectional-study
#12
Ghadeer K Al-Shaikh, Gehan H Ibrahim, Amel A Fayed, Hazem Al-Mandeel
BACKGROUND: Low serum vitamin D [25(OH)D] has been associated with different health problems worldwide. However, its causal role in several diseases remains unclear. We aimed to correlate vitamin D status with maternal and neonatal outcomes in pregnant females. METHOD: One thousand pregnant women were recruited during early labour from the labour ward of King Khaled University Hospital, Riyadh, Saudi Arabia. Detailed medical data of all participants were collected from their records...
May 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27103201/vitamin-d-binding-protein-and-25-hydroxyvitamin-d-during-pregnancy-in-mothers-whose-children-later-developed-type-1-diabetes
#13
Ingvild M Sørensen, Geir Joner, Pål A Jenum, Anne Eskild, Cathrine Brunborg, Peter A Torjesen, Lars C Stene
BACKGROUND: Levels of 25-hydroxyvitamin D (25-OH D) during late pregnancy have been linked to type 1 diabetes risk in the offspring. Vitamin D-binding protein (DBP) increases in concentration during pregnancy. We aimed to test whether concentrations of DBP and 25-OH D throughout pregnancy differed between women whose offspring later developed type 1 diabetes (cases) and controls. METHODS: A nested case-control study was conducted within a cohort of pregnant women from all over Norway in 1992-94...
April 21, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27038010/umbilical-cord-serum-25-hydroxyvitamin-d-concentrations-and-relation-to-birthweight-head-circumference-and-infant-length-at-age-14-days
#14
Christine Dalgård, Maria Skaalum Petersen, Ulrike Steuerwald, Pál Weihe, Philippe Grandjean
BACKGROUND: Insufficient supply of vitamin D during early development may negatively affect offspring growth. METHODS: We examined the association between umbilical cord (UC) serum 25-hydroxyvitamin D (25(OH)D) concentrations and infant size in a study of two Faroese birth cohorts of 1038 singleton infants. In the third trimester, the pregnant women completed questionnaires, and clinical examination included birthweight, head circumference, and infant length at age 14 days...
May 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/26882050/influence-of-vitamin-d-and-parathyroid-hormone-on-bone-and-metabolic-risk-in-women-with-previous-gestational-diabetes
#15
M C Serra, A S Ryan
The purpose of this study was to compare plasma 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), VO2max, bone (by DXA), and metabolic outcomes across age and race-matched postmenopausal women (54±1 years; mean±SEM): 1) with previous gestational diabetes (GDM) (32±1 kg/m(2); n=17), 2) without previous GDM, but with a similar BMI to GDM (32±1 kg/m(2); n=17), and 3) without previous GDM, but with a higher BMI than GDM (36±1 kg/m(2); n=17; p<0.01). The prevalence of 25(OH)D insufficiency and deficiency was high (~80%), but not different across groups, while PTH tended to be ~30% lower in women with a history of GDM (p=0...
August 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/26870091/association-of-vitamin-d-receptor-gene-bsmi-a-g-and-foki-c-t-polymorphism-in-gestational-diabetes-among-saudi-women
#16
Hesham A El-Beshbishy, Manal A Tawfeek, Inass M Taha, Thoraya FadulElahi, Amal Y Shaheen, Fouad A Bardi, Intessar I Sultan
OBJECTIVE: Vitamin D receptor (VDR) gene polymorphism have a role in diabetes mellitus pathogenesis. Present study was conducted to determine VDR gene variants among Saudi gestational diabetics (GDM) in Madina, KSA. METHODS: This cross sectional study was conducted on 112 GDM patients and 218 normal healthy control. Age, body mass index and blood pressure levels were recorded. Serum triglycerides (mg/dl), total cholesterol, HDL-cholesterol, LDL-cholesterol, fasting blood glucose FBG and post-prandial blood glucose PPBG were estimated...
November 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26848814/vitamin-d-status-and-gestational-diabetes-effect-of-smoking-status-during-pregnancy
#17
Linda Dodds, Christy G Woolcott, Hope Weiler, Anne Spencer, Jean-Claude Forest, B Anthony Armson, Yves Giguère
BACKGROUND: Vitamin D status, as measured by serum 25-hydroxyvitamin D (25(OH)D), has been shown in some studies to be inversely associated with gestational diabetes risk. Recently, it has been suggested that maternal smoking status may modify this relationship. We explored the association between 25(OH)D concentration and gestational diabetes and determined if there was an interaction between smoking and 25(OH)D. METHODS: A nested case-control study was conducted in Halifax, Nova Scotia and Quebec City, Quebec...
May 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/26824237/gestational-diabetes-mellitus
#18
REVIEW
Caroline Spaight, Justine Gross, Antje Horsch, Jardena Jacqueline Puder
Based on the Hyperglycemia and Adverse Pregnancy Outcome study, new universal screening recommendations and cut-offs for gestational diabetes mellitus (GDM) have been proposed. In addition to the immediate perinatal risk, GDM carries an increased risk of metabolic disease in the mother and child. Maternal obesity has even been shown to be associated with increased all-cause mortality in offspring. In addition to known risk factors, excessive gestational weight gain, increased fat consumption, a low vitamin D level, psychological stress and negative mood are risk factors for GDM...
2016: Endocrine Development
https://www.readbyqxmd.com/read/26784653/association-between-vitamin-d-receptor-apai-and-taqi-gene-polymorphisms-and-gestational-diabetes-mellitus-in-an-iranian-pregnant-women-population
#19
Golzar Rahmannezhad, Farideh Jalali Mashayekhi, Mohammad Taghi Goodarzi, Mohammad Reza Rezvanfar, Abdorrahim Sadeghi
It has been proposed that variants of the nuclear vitamin D receptor (VDR) gene are associated with a susceptibility to type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). Our study was aimed to evaluate a possible association between the VDR ApaI (rs7975232) and TaqI (rs731236) gene polymorphisms and susceptibility to GDM in an Iranian pregnant women population. This case-control study was performed on a population of pregnant Iranian women, including 157 GDM and 157 non-GDM subjects.VDR ApaI and TaqI polymorphisms were assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
April 25, 2016: Gene
https://www.readbyqxmd.com/read/26692878/severe-vitamin-d-deficiency-in-preterm-infants-maternal-and-neonatal-clinical-features
#20
Sook-Hyun Park, Gi-Min Lee, Jung-Eun Moon, Heng-Mi Kim
PURPOSE: We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency. METHODS: A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collected maternal and neonatal data such as maternal gestational diabetes, premature rupture of membranes, maternal preeclampsia, birth date, gestational age, and birth weight...
November 2015: Korean Journal of Pediatrics
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