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association of vitamin d with gestational diabetes

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https://www.readbyqxmd.com/read/28276579/glucose-homeostasis-beta-cell-function-and-insulin-resistance-in-relation-to-vitamin-d-status-after-gestational-diabetes-mellitus
#1
Nael Shaat, Claes Ignell, Anastasia Katsarou, Kerstin Berntorp
INTRODUCTION: We wanted to determine vitamin D status after gestational diabetes mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D3 (25OHD3 ) are associated with beta cell function, insulin resistance, or a diagnosis of diabetes after GDM. MATERIAL AND METHODS: Glucose homeostasis was assessed during a 75-g oral glucose tolerance test 1-2 years after delivery in 376 women with previous GDM (287 European and 78 non-European, including 33 Arab and 35 Asian women)...
March 9, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28244707/serum-25-hydroxyvitamin-d-in-pregnant-women-during-preterm-labor
#2
Nalina Bhupornvivat, Vorapong Phupong
BACKGROUND AND OBJECTIVES: Pregnancy complications hypothesized to be related to vitamin D include preeclampsia, gestational diabetes, low birth weight, preterm delivery, Cesarean section and infectious disease. There have been a few studies which have demonstrated maternal serum vitamin D to be associated with preterm labor. The objective was to evaluate the serum vitamin D concentrations in Thai pregnant women with and without preterm labor and to find the prevalence of vitamin D deficiency and insufficiency in both groups...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28212289/the-effects-of-myo-inositol-and-b-and-d-vitamin-supplementation-in-the-db-mouse-model-of-gestational-diabetes-mellitus
#3
Jasmine F Plows, Florence Budin, Rebecka A M Andersson, Valerie J Mills, Katherine Mace, Sandra T Davidge, Mark H Vickers, Philip N Baker, Irma Silva-Zolezzi, Joanna L Stanley
Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams)...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28120286/adverse-perinatal-outcomes-and-postpartum-multi-systemic-dysregulation-adding-vitamin-d-deficiency-to-the-allostatic-load-index
#4
Eynav Elgavish Accortt, James Mirocha, Christine Dunkel Schetter, Calvin J Hobel
Background Allostatic load (AL) is an index of multi-system physiological "wear-and-tear," operationalizing emergent chronic disease risk and predicting morbidity and mortality. AL has been proposed as an organizing framework for studying pregnancy outcomes and additional AL biomarkers for the study of maternal health would be valuable. Objectives To test whether adverse perinatal outcomes are associated with postpartum AL and if including vitamin D deficiency (serum 25(OH)D < 20 ng/ml) as an additional marker of postpartum AL increases the association...
March 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27933507/determinants-of-maternal-vitamin%C3%A2-d-concentrations-in-slovenia-a%C3%A2-prospective-observational-study
#5
Andraž Dovnik, Faris Mujezinović, Milena Treiber, Breda Pečovnik Balon, Maksimiljan Gorenjak, Uroš Maver, Iztok Takač
OBJECTIVE: To analyze the vitamin D status of pregnant women in Slovenia and the factors influencing it. METHODS: The study was performed in Maribor University Medical Centre (location 46°N). Maternal serum 25-hydroxy-vitamin D (25(OH)D) in 4 groups of 100 pregnant women in 4 different seasons of the year was measured at the time of delivery. Data on life style, eating habits, sunbathing and intake of vitamin D supplements during pregnancy were obtained using a questionnaire...
January 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27843556/seasonality-of-gestational-diabetes-mellitus-a-south-australian-population-study
#6
Petra E Verburg, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Gus A Dekker, Claire T Roberts
OBJECTIVE: To investigate whether there is a seasonal variation in the incidence of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: This retrospective cohort study of 60 306 eligible South Australian live-born singletons during 2007-2011 recorded in the South Australian Perinatal Statistics Collection (SAPSC) examined the incidence of GDM in relation to estimated date of conception (eDoC). Fourier series analysis was used to model seasonal trends...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27764194/vitamin-d-deficiency-increases-the-risk-of-adverse-neonatal-outcomes-in-gestational-diabetes
#7
Letícia Schwerz Weinert, Angela Jacob Reichelt, Leonardo Rauber Schmitt, Roberta Boff, Maria Lucia Rocha Oppermann, Joiza Lins Camargo, Sandra Pinho Silveiro
BACKGROUND: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. METHODS: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement...
2016: PloS One
https://www.readbyqxmd.com/read/27753425/the-relationship-between-25-hydroxyvitamin-d-concentration-in-early-pregnancy-and-pregnancy-outcomes-in-a-large-prospective-cohort
#8
Veronica T Boyle, Eric B Thorstensen, David Mourath, M Beatrix Jones, Lesley M E McCowan, Louise C Kenny, Philip N Baker
Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27690002/serum-25-oh-vitamin-d-levels-in-polish-women-during-pregnancies-complicated-by-hypertensive-disorders-and-gestational-diabetes
#9
Piotr Domaracki, Pawel Sadlecki, Grazyna Odrowaz-Sypniewska, Ewa Dzikowska, Pawel Walentowicz, Joanna Siodmiak, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
BACKGROUND: An association between the level of vitamin D and the risk of pregnancy-related complications remains unclear. The aim of this study was to examine concentrations of 25(OH) vitamin D in Polish women with normal pregnancies and pregnancies complicated by gestational hypertension, preeclampsia or gestational diabetes mellitus (GDM). Moreover, we analyzed an association between maternal serum 25(OH)D and the risk of gestational hypertension, preeclampsia and GDM. MATERIAL AND METHODS: The study included 207 pregnant women, among them 171 with pregnancy-related complications: gestational hypertension (n = 45), preeclampsia (n = 23) or GDM (n = 103)...
September 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27679649/the-impact-of-vitamin-d-supplementation-on-post-partum-glucose-tolerance-and-insulin-resistance-in-gestational-diabetes-a-randomized-controlled-trial
#10
Majid Valizadeh, Zahra Piri, Farnaz Mohammadian, Koorosh Kamali, Hamid Reza Amir Moghadami
BACKGROUND: Hypovitaminosis D has been associated with the development of gestational diabetes mellitus (GDM) in many observational studies. OBJECTIVES: We report the first study of the impact of prenatal vitamin D supplementation on postpartum dysglycemia in GDM patients in a randomized clinical trial. PATIENTS AND METHODS: Women with GDM at 12 - 32 weeks of gestation were assigned randomly to either the intervention group (in which serum 25-hydroxy vitamin D [25OHD] levels were measured immediately, n = 48) or the control group (in which the serum was stored and assayed at 6 - 12 weeks post-partum, n = 48)...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27651580/prevalence-of-vitamin-d-deficiency-in-burka-clad-pregnant-women-in-a-450-bedded-maternity-hospital-of-delhi
#11
Sangita Nangia Ajmani, Mohini Paul, Poonam Chauhan, A K Ajmani, Namrta Yadav
AIM: To assess the prevalence of vitamin D deficiency in burka-clad pregnant women and to study feto-maternal outcome in these women. METHODS: 200 pregnant burka-clad women of 18-40-year age group irrespective of the period of gestation were recruited from the ANC OPD/ward of Kasturba hospital, and their vitamin D levels were estimated. Patients were categorized into vitamin D deficient, vitamin D inadequate, and vitamin D adequate according to The Endocrine Society Guidelines...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27636996/genetic-variants-in-vitamin-d-signaling-pathways-and-risk-of-gestational-diabetes-mellitus
#12
Aiwu Shi, Juan Wen, Guangquan Liu, Heng Liu, Ziyi Fu, Jing Zhou, Yao Zhu, Yaoqiu Liu, Xirong Guo, Jianguo Xu
Vitamin D (VD) deficiency during pregnancy has been repeatedly linked to an increased gestational diabetes mellitus (GDM) risk. We sought to determine the influences of genetic variants in vitamin D signaling pathways on the risk of GDM. In this study, we genotyped 15 single nucleotide polymorphisms (SNPs) within 8 representative genes (CYP27A1, CYP27B1, CYP24A1, VDR, RXRA, RXRB, RXRG and GC) of the vitamin D signaling pathways in a case-control study with 964 GDM cases and 1,021 controls using the Sequenom MassARRAY iPLEX platform...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27588106/effect-of-various-doses-of-vitamin-d-supplementation-on-pregnant-women-with-gestational-diabetes-mellitus-a-randomized-controlled-trial
#13
Qingying Zhang, Yan Cheng, Mulan He, Tingting Li, Ziwen Ma, Haidong Cheng
It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM)...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27558700/vitamin-d-and-its-impact-on-maternal-fetal-outcomes-in-pregnancy-a-critical-review
#14
Shreya Agarwal, Oormila Kovilam, Devendra K Agrawal
The role of vitamin D beyond its classical function in calcium homeostasis has been of significant interest in recent years. There has been expanding research on the pleiotropic role of vitamin D in pregnancy and the implications of its deficiency on maternal-fetal outcomes. Several studies have associated low maternal vitamin D status to adverse outcomes in pregnancy, including preeclampsia, gestational diabetes, preterm births, low birth weight, and others. Several randomized controlled clinical trials of Vitamin D supplementation during pregnancy have also been conducted...
August 24, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27424441/-maternal-serum-25-hydroxy-vitamin-d-levels-in-the-first-trimester-and-adverse-gestational-outcomes
#15
E Álvarez-Silvares, M Vilouta-Romero, E Borrajo-Hernández, M L Morales-Serrano, M T Alves-Pérez
BACKGROUND: Some disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today. OBJECTIVE: The aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction. MATERIAL AND METHOD: We conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N)...
March 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27221615/impact-of-vitamin-d-deficiency-on-maternal-and-birth-outcomes-in-the-saudi-population-a-cross-sectional-study
#16
Ghadeer K Al-Shaikh, Gehan H Ibrahim, Amel A Fayed, Hazem Al-Mandeel
BACKGROUND: Low serum vitamin D [25(OH)D] has been associated with different health problems worldwide. However, its causal role in several diseases remains unclear. We aimed to correlate vitamin D status with maternal and neonatal outcomes in pregnant females. METHOD: One thousand pregnant women were recruited during early labour from the labour ward of King Khaled University Hospital, Riyadh, Saudi Arabia. Detailed medical data of all participants were collected from their records...
May 24, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27103201/vitamin-d-binding-protein-and-25-hydroxyvitamin-d-during-pregnancy-in-mothers-whose-children-later-developed-type-1-diabetes
#17
Ingvild M Sørensen, Geir Joner, Pål A Jenum, Anne Eskild, Cathrine Brunborg, Peter A Torjesen, Lars C Stene
BACKGROUND: Levels of 25-hydroxyvitamin D (25-OH D) during late pregnancy have been linked to type 1 diabetes risk in the offspring. Vitamin D-binding protein (DBP) increases in concentration during pregnancy. We aimed to test whether concentrations of DBP and 25-OH D throughout pregnancy differed between women whose offspring later developed type 1 diabetes (cases) and controls. METHODS: A nested case-control study was conducted within a cohort of pregnant women from all over Norway in 1992-94...
April 21, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27038010/umbilical-cord-serum-25-hydroxyvitamin-d-concentrations-and-relation-to-birthweight-head-circumference-and-infant-length-at-age-14-days
#18
MULTICENTER STUDY
Christine Dalgård, Maria Skaalum Petersen, Ulrike Steuerwald, Pál Weihe, Philippe Grandjean
BACKGROUND: Insufficient supply of vitamin D during early development may negatively affect offspring growth. METHODS: We examined the association between umbilical cord (UC) serum 25-hydroxyvitamin D (25(OH)D) concentrations and infant size in a study of two Faroese birth cohorts of 1038 singleton infants. In the third trimester, the pregnant women completed questionnaires, and clinical examination included birthweight, head circumference, and infant length at age 14 days...
May 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/26882050/influence-of-vitamin-d-and-parathyroid-hormone-on-bone-and-metabolic-risk-in-women-with-previous-gestational-diabetes
#19
M C Serra, A S Ryan
The purpose of this study was to compare plasma 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), VO2max, bone (by DXA), and metabolic outcomes across age and race-matched postmenopausal women (54±1 years; mean±SEM): 1) with previous gestational diabetes (GDM) (32±1 kg/m(2); n=17), 2) without previous GDM, but with a similar BMI to GDM (32±1 kg/m(2); n=17), and 3) without previous GDM, but with a higher BMI than GDM (36±1 kg/m(2); n=17; p<0.01). The prevalence of 25(OH)D insufficiency and deficiency was high (~80%), but not different across groups, while PTH tended to be ~30% lower in women with a history of GDM (p=0...
August 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/26870091/association-of-vitamin-d-receptor-gene-bsmi-a-g-and-foki-c-t-polymorphism-in-gestational-diabetes-among-saudi-women
#20
Hesham A El-Beshbishy, Manal A Tawfeek, Inass M Taha, Thoraya FadulElahi, Amal Y Shaheen, Fouad A Bardi, Intessar I Sultan
OBJECTIVE: Vitamin D receptor (VDR) gene polymorphism have a role in diabetes mellitus pathogenesis. Present study was conducted to determine VDR gene variants among Saudi gestational diabetics (GDM) in Madina, KSA. METHODS: This cross sectional study was conducted on 112 GDM patients and 218 normal healthy control. Age, body mass index and blood pressure levels were recorded. Serum triglycerides (mg/dl), total cholesterol, HDL-cholesterol, LDL-cholesterol, fasting blood glucose FBG and post-prandial blood glucose PPBG were estimated...
November 2015: Pakistan Journal of Medical Sciences Quarterly
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