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https://www.readbyqxmd.com/read/29458142/insufficient-radiofrequency-ablation-promotes-proliferation-of-residual-hepatocellular-carcinoma-via-autophagy
#1
Zizhuo Zhao, Jiayi Wu, Xiaodi Liu, Ming Liang, Xinchuan Zhou, Shi Ouyang, Jiyi Yao, Jinquan Wang, Baoming Luo
Radiofrequency ablation (RFA) is considered to be a potentially curative therapy for hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can promote rapid progression of the residual tumor. The mechanisms underlying IRFA-induced tumor promotion remain poorly understood. In the present study, we have established a subcutaneous xenograft mouse model and monitored the location and extent of IRFA by dual monitoring with ultrasonography and a thermal imager. For the first time, we provide evidence of the activation of autophagic pathways in mice exposed to IRFA...
February 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29457964/liver-imaging-reporting-and-data-system-patient-outcomes-for-category-4-and-5-nodules
#2
Sang Hyun Choi, Jae Ho Byun, Young-Suk Lim, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin, Pyo-Nyun Kim
Purpose To determine the outcomes after initial therapy in patients with chronic liver disease and retrospectively assigned Liver Imaging Reporting and Data System (LI-RADS; version 2014) category 4 (LR-4) and 5 (LR-5) nodules at gadoxetate disodium-enhanced MR imaging. Materials and Methods In this retrospective study, 260 patients with a single LR-4 (n = 132) or LR-5 (n = 128) nodule who were assigned a LI-RADS category were included. Patients were identified between January 2012 and December 2012, and were initially treated by resection, liver transplant, radiofrequency ablation (RFA), or transcatheter arterial chemoembolization (TACE) according to the Barcelona Clinic Liver Cancer staging system...
February 19, 2018: Radiology
https://www.readbyqxmd.com/read/29457524/safety-and-effect-on-ablation-size-of-hydrochloric-acid-perfused-radiofrequency-ablation-in-animal-livers
#3
Tian-Qi Zhang, Sen-Miao Huang, Yang-Kui Gu, Fei Gao, Zhi-Mei Huang, Xiong-Ying Jiang, Ding-Xin Liu, Jin-Hua Huang
PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissue, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103°C and 30 W for 3 minutes. For each experimental setting, 6 ablations were created...
February 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29457510/hepatocellular-carcinoma-abutting-large-vessels-comparison-of-four-percutaneous-ablation-systems
#4
Amélie Loriaud, Alban Denys, Olivier Seror, Naik Vietti Violi, Antonia Digklia, Rafael Duran, Hervé Trillaud, Arnaud Hocquelet
PURPOSE: To compare overall local tumor progression (OLTP), defined as the failure of primary ablation or local tumor progression, with single applicator monopolar RFA, microwave ablation (MWA), cluster-RFA and multibipolar radiofrequency (mbpRFA) in the treatment of HCC≤5cm abutting large vessels (≥3mm). METHOD AND MATERIALS: This multicenter, retrospective, per-nodule study was performed from 2007 to 2015. The study was approved by the ethics review board, and informed consent was waived...
February 18, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29454099/two-stage-hepatectomy-vs-one-stage-major-hepatectomy-with-contralateral-resection-or-ablation-for-advanced-bilobar-colorectal-liver-metastases
#5
Takashi Mizuno, Jordan M Cloyd, Kiyohiko Omichi, Yun Shin Chun, Claudius Conrad, Ching-Wei D Tzeng, Steven H Wei, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Both two-stage hepatectomy (TSH) and one-stage hepatectomy (OSH) represent feasible strategies for resection of advanced bilobar colorectal liver metastases (CLM). However, the influence of the surgical approach on postoperative outcomes and overall survival (OS) is unknown. To define the optimal surgical approach for advanced bilobar CLM requiring right hemihepatectomy, we compared short-term and long-term outcomes following TSH and OSH with contralateral resection or radiofrequency ablation (RFA)...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29448289/lessons-from-pathological-analysis-of-recurrent-early-esophageal-squamous-cell-neoplasia-after-complete-endoscopic-radiofrequency-ablation
#6
Wen-Lun Wang, I-Wei Chang, Chien-Chuan Chen, Chi-Yang Chang, Cheng-Hao Tseng, Chi-Ming Tai, Jaw-Town Lin, Hsiu-Po Wang, Ching-Tai Lee
BACKGROUND: Endoscopic radiofrequency ablation (RFA) is a treatment option for early esophageal squamous cell neoplasia (ESCN); however, long-term follow-up studies are lacking. The risks of local recurrence and "buried cancer" are also uncertain. METHODS: Patients with flat-type ESCN who were treated with balloon-type ± focal-type RFA were consecutively enrolled. Follow-up endoscopy was performed at 1, 3, and 6 months, and then every 6 months thereafter...
February 15, 2018: Endoscopy
https://www.readbyqxmd.com/read/29444219/complex-cases-of-acquired-pulmonary-vein-stenosis-after-radiofrequency-ablation-is-surgical-repair-an-option
#7
Katharina Schoene, Philipp Sommer, Arash Arya, Martin Kostelka, Friedrich W Mohr, Martin Misfeld, Marcel Vollroth, Andreas Bollmann, Julia Lurz, Gerhard Hindricks, Joerg Seeburger
Aims: Results of catheter based interventional treatment for pulmonary vein stenosis (PVS) following radiofrequency ablation (RFA) for atrial fibrillation remain suboptimal. Surgical repair may represent an alternative therapy, though long-term results have not been thoroughly investigated. Methods and results: We retrospectively assessed all patients in our centre undergoing surgical repair for radiofrequency-induced PVS. Data regarding surgical technique, clinical outcome, and rate of pulmonary vein (PV) restenosis were collected and analysed...
February 12, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29444164/evolution-of-nodule-stiffness-might-predict-response-to-local-ablative-therapy-a-series-of-patients-with-hepatocellular-carcinoma
#8
Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P Strassburg, Jonel Trebicka, Maria A Gonzalez Carmona
BACKGROUND: Early information on treatment response of HCC to local ablative therapy is crucial. Elastography as a non-invasive method has recently been shown to play a potential role in distinguishing between benign and malignant liver lesions. Elastography of hepatocellular carcinoma (HCC) in early response to local ablative therapy has not been studied to date. METHODS: We prospectively included a cohort of 14 patients with diagnosis of HCC who were treated with local ablative therapy (transarterial chemoembolization, TACE and/or radiofrequency ablation, RFA)...
2018: PloS One
https://www.readbyqxmd.com/read/29441744/cryoballoon-ablation-for-atrial-fibrillation-a-comprehensive-review-and-practice-guide
#9
REVIEW
Eun Sun Jin, Paul J Wang
The cryoballoon was invented to achieve circumferential pulmonary vein isolation more efficiently to compliment the shortcomings of point-by-point ablation by radiofrequency ablation (RFA). Its efficacy and safety were shown to be comparable to those of RFA, and the clinical outcomes have improved with the second-generation cryoballoon. The basic biophysics, implemental techniques, procedural recommendations, clinical outcomes, and complications of the cryoballoon are presented in this practical and systematic review...
February 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29441336/a-prospective-randomized-study-comparing-radiofrequency-ablation-and-hepatic-resection-for-hepatocellular-carcinoma
#10
Hae Won Lee, Jeong Min Lee, Jung-Hwan Yoon, Yoon Jun Kim, Joong-Won Park, Sang-Jae Park, Seong Hoon Kim, Nam-Joon Yi, Kyung-Suk Suh
Purpose: Although there are several prospective clinical studies comparing radiofrequency ablation (RFA) and hepatic resection (HR) for the treatment of hepatocellular carcinoma, there are few trials that have been performed in strictly homogeneous patients. Methods: Patients who were newly diagnosed with a solitary hepatocellular carcinoma were randomized to the HR or RFA group. Inclusion criteria were as follows: age ≥ 20 years but ≤ 70 years, Child-Pugh class A, maximal diameter of the tumor ≥ 2 cm but ≤ 4 cm, no previous treatment history, and platelet count > 80,000/mm 3 ...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29435018/thermographic-real-time-monitoring-of-surgical-radiofrequency-and-microwave-ablation-in-a-perfused-porcine-liver-model
#11
Florian Primavesi, Stefan Swierczynski, Eckhard Klieser, Tobias Kiesslich, Tarkan Jäger, Romana Urbas, Jörg Hutter, Daniel Neureiter, Dietmar Öfner, Stefan Stättner
Radiofrequency ablation (RFA) and microwave ablation (MWA) are currently the dominant modalities to treat unresectable liver tumors. Monitoring the ablation process with b-mode-sonography is often hampered by artefacts. Furthermore, vessels may cause cooling in the adjacent tumor target (heat-sink-effect) with risk of local recurrence. The present study evaluated infrared-thermography to monitor surgical RFA/MWA and detect heat-sink-effects in real-time. RFA and MWA of perfused porcine livers was conducted at peripheral and central-vessel-adjacent locations, and monitored by real-time thermography...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29426988/rfa-versus-robotic-partial-nephrectomy-for-t1a-renal-cell-carcinoma-a-propensity-score-matched-comparison-of-mid-term-outcome
#12
Byung Kwan Park, In Hyuck Gong, Min Yong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Soo Jeon, Hyun Moo Lee, Seong Il Seo
OBJECTIVE: To compare oncological and functional mid-term outcomes following robotic partial nephrectomy (RPN) and radiofrequency ablation (RFA) for treating T1a renal cell carcinoma (RCC) using propensity score-matching. METHODS: Between December 2008-April 2016, 63 patients from each treatment group were propensity score-matched for age, sex, American Society of Anesthesiologists score, tumour size, tumour laterality, tumour histology, R.E.N.A.L. nephrometry score and preoperative estimated glomerular filtration rate (eGFR)...
February 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29423737/aggressive-and-multidisciplinary-local-approach-to-iterative-recurrences-of-colorectal-liver-metastases
#13
Luca Viganò, Vittorio Pedicini, Tiziana Comito, Carlo Carnaghi, Guido Costa, Dario Poretti, Ciro Franzese, Nicola Personeni, Daniele Del Fabbro, Lorenza Rimassa, Marta Scorsetti, Armando Santoro, Luigi Solbiati, Guido Torzilli
BACKGROUND: Liver resection (LR) of colorectal metastases is associated with high recurrence risk. Aggressive local retreatment is advocated, but further recurrences may occur. Poor is known about presentation, treatment, and outcome of iterative recurrences. METHODS: A series of 323 consecutive patients undergoing first LR in the period 2004-2013 was reviewed. Patients with recurrence were included. Any local treatment (surgery, radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT)) was analyzed...
February 8, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29420589/comparison-of-switching-bipolar-ablation-with-multiple-cooled-wet-electrodes-and-switching-monopolar-ablation-with-separable-clustered-electrode-in-treatment-of-small-hepatocellular-carcinoma-a-randomized-controlled-trial
#14
Won Chang, Jeong Min Lee, Dong Ho Lee, Jeong Hee Yoon, Yoon Jun Kim, Jung Hwan Yoon, Joon Koo Han
OBJECTIVE: A randomized controlled trial was conducted to prospectively compare the therapeutic effectiveness of switching bipolar (SB) radiofrequency ablation (RFA) using cooled-wet electrodes and switching monopolar (SM) RFA using separable clustered (SC) electrodes in patients with hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: This prospective study was approved by our Institutional Review Board. Between April 2014 and January 2015, sixty-nine patients with 74 HCCs were randomly treated with RFA using either internally cooled-wet (ICW) electrodes in SB mode (SB-RFA, n = 36) or SC electrodes in SM mode (SM-RFA, n = 38)...
2018: PloS One
https://www.readbyqxmd.com/read/29415262/anatomical-comparison-of-radiofrequency-ablation-techniques-for-sacroiliac-joint-pain
#15
Shannon L Roberts, Alison Stout, Eldon Y Loh, Nathan Swain, Paul Dreyfuss, Anne M Agur
Objective: To compare the percentage of sacral lateral branches (LBs) that would be captured if lesions were created by seven current sacroiliac joint (SIJ) radiofrequency ablation (RFA) techniques: three monopolar and four bipolar. Design: Cadaveric fluoroscopy study. Setting: Anatomy and surgical skills laboratories. Subjects: Forty cadaveric SIJs. Methods: LBs were exposed, radiopaque wires were sutured to LBs, and anterior-posterior fluoroscopic images through the S1 superior endplate were obtained...
February 5, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29412017/transcatheter-arterial-chemoembolization-with-or-without-radiofrequency-ablation-outcomes-in-patients-with-barcelona-clinic-liver-cancer-stage-b-hepatocellular-carcinoma
#16
Masashi Hirooka, Atsushi Hiraoka, Hironori Ochi, Yoshiyasu Kisaka, Kouji Joko, Kojiro Michitaka, Yoichi Hiasa
OBJECTIVE: The objective of our study was to clarify the indications for transcatheter arterial chemoembolization (TACE) of the hepatic artery combined with radiofrequency ablation (RFA), which we refer to as "TACE-RFA," for patients with hepatocellular carcinoma (HCC) beyond the Milan criteria. This study assessed the prognoses of patients with intermediate-stage HCC, which we defined as Barcelona Clinic Liver Cancer (BCLC) stage B (hereafter referred to as BCLC-B), according to the BCLC-B substages through treatment in a multicenter study...
February 7, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29410287/no-touch-multibipolar-radiofrequency-ablation-vs-surgical-resection-for-solitary-hepatocellular-carcinoma-ranging-from-2-to-5-cm
#17
Kayvan Mohkam, Paul-Noël Dumont, Anne-Frédérique Manichon, Jean-Christophe Jouvet, Loïc Boussel, Philippe Merle, Christian Ducerf, Mickaël Lesurtel, Agnès Rode, Jean-Yves Mabrut
BACKGROUND: No touch multibipolar radiofrequency ablation (NTM-RFA) represents a novel therapy that surpasses standard RFA for hepatocellular carcinoma (HCC), but it was never compared to surgical resection (SR). We aimed to compare outcomes of NTM-RFA and SR for intermediate-sized HCC. METHODS: Between 2012 and 2016, outcomes of patients primarily treated for solitary HCC ranging from 2 to 5 cm by NTM-RFA or SR at a single-center were compared using inverse probability of treatment weighting (IPTW)...
February 1, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29408592/stereotactic-radiofrequency-thermocoagulation-of-hypothalamic-hamartoma-using-robotic-guidance-rosa-co-registered-with-o-arm-guidance-preliminary-technical-note
#18
Vivek Tandon, Poodipedi Sarat Chandra, Ramesh Sharanappa Doddamani, Heri Subianto, Jitin Bajaj, Ajay Garg, Manjari Tripathi
INTRODUCTION: Treatment options for hypothalamic hamartoma (HH) include microvascular surgery, stereotactic radiofrequency thermocoagulation (SRT), laser interstitial thermal therapy (LITT) or Gamma knife surgery (GKS). During SRT, thermographic monitoring cannot be performed and therefore highly accurate placement of electrode and confirmation of its position are required. We have utilized robotic guidance (ROSA) and co-registered it with O-Arm, for performing ablation of hamartoma. METHODS: Five patients of HH with gelastic seizures (GS) underwent SRT...
February 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29404481/long-term-survival-after-surveillance-and-treatment-in-patients-with-chronic-viral-hepatitis-and-hepatocellular-carcinoma
#19
Myron J Tong, Alexander A Rosinski, Claiborne T Huynh, Steven S Raman, David S K Lu
Hepatocellular carcinoma (HCC) is the main cause of mortality in patients with chronic viral hepatitis (CVH). We determined the impact of surveillance and treatments on long-term outcomes in patients with CVH who developed HCC. Between 1984 and 2014, 333 patients with HCC and with hepatitis B or hepatitis C virus infection were evaluated. An adjusted lead time bias interval was added to patients with HCC who presented with HCC (no surveillance), and their survival was compared to patients whose HCC was detected by surveillance...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29404285/role-of-percutaneous-computed-tomography-guided-radiofrequency-ablation-in-treatment-of-osteoid-osteoma
#20
Ajay R Upadhyay, Nikunj Chandrakant Desai, Digish U Vaghela
Aim: The aim of the study was to evaluate efficacy of percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) of nidus in osteoid osteoma (OO). Materials and Methods: RFA was performed on fifty patients with clinically and radiologically diagnosed OO. RFA was done in the department of radio-diagnosis in our institute (a tertiary care providing institute in Ahmedabad, Western India). Ablation was performed by putting at an electrode tip (3-5 mm) into nidus under CT guidance with targeted temperature of 90°C for 3 min...
October 2017: South Asian Journal of Cancer
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