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https://www.readbyqxmd.com/read/28816408/endoscopic-treatment-of-barrett-s-esophagus-what-can-we-learn-from-the-western-perspective
#1
REVIEW
Yuto Shimamura, Yugo Iwaya, Kenichi Goda, Christopher W Teshima
The incidence of Barrett's esophagus (BE) related neoplasia in Western countries has increased in the past several decades, and even in Eastern countries, it appears to be increasing. Endoscopic therapies are the first-line treatment for BE-related neoplasia, however there is still no standardized treatment strategy. Most of the data have been published from Western countries where the ultimate goal of treatment is complete eradication of BE mucosa removing subtle synchronous lesions and preventing metachronous neoplasia...
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28811965/adjuvant-immunotherapy-with-autologous-dendritic-cells-for-hepatocellular-carcinoma-randomized-phase-ii-study
#2
Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Yong-Soo Bae, Yoon Jun Kim
Our previous phase I/IIA study showed that autologous dendritic cells (DCs) pulsed with tumor-associated antigens are well tolerated in patients with hepatocellular carcinoma (HCC). In this randomized, multicenter, open-label, phase II trial, we investigated the efficacy and safety of this DC-based adjuvant immunotherapy with 156 patients, who treated for HCC with no evidence of residual tumor after standard treatment modalities. Patients were randomly assigned to immunotherapy (n = 77; injection of 3 × 10(7) DC cells, six times over 14 weeks) or control (n = 79; no treatment)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28809734/wait-time-for-curative-intent-radio-frequency-ablation-is-associated-with-increased-mortality-in-patients-with-early-stage-hepatocellular-carcinoma
#3
Mayur Brahmania, Osman Ahmed, Melissa Kelley, David Wong, Matthew Kowgier, Korosh Khalili, Rob Beecroft, Eberhard L Renner, Hemant Shah, Jordan Feld, Harry L A Janssen, Morris Sherman
INTRODUCTION: Radiofrequency ablation (RFA) is a recommended curative intent treatment option for patients with early stage hepatocellular carcinoma (HCC). We investigated if wait times for RFA were associated with residual tumor, tumor recurrence, need for liver transplantation, or death. MATERIAL AND METHODS: We conducted a retrospective study of patients diagnosed with HCC between January 2010 and December 2013 presenting to University Health Network (UHN) in Toronto, Canada...
August 8, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28807571/radiofrequency-ablation-for-osteoid-osteoma-recurrence-rates-and-predictive-factors
#4
David W Shields, Sadaf Sohrabi, Evan O Crane, Chris Nicholas, Ashish Mahendra
BACKGROUND AND PURPOSE: Osteoid osteoma is an infrequent but debilitating benign bone lesion which can be successfully managed by percutaneous radiofrequency ablation (RFA). There are few studies investigating the efficacy and follow-up of this treatment. An arbitrary upper limit of 15 mm has been used to differentiate between osteoid osteoma and osteoblastoma with surgery used for lesions above this limit. We aimed to analyse the cases identified from our prospectively maintained database over a ten year period since adoption of this technique in our unit...
August 11, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28807570/albumin-bilirubin-grade-predicts-the-outcomes-of-liver-resection-versus-radiofrequency-ablation-for-very-early-early-stage-of-hepatocellular-carcinoma
#5
Charing Ching-Ning Chong, Anthony Wing-Hung Chan, John Wong, Cheuk-Man Chu, Stephen Lam Chan, Kit-Fai Lee, Simon Chun-Ho Yu, Ka-Fai To, Philip Johnson, Paul Bo-San Lai
BACKGROUND AND PURPOSE: Whether liver resection or ablation should be the first-line treatment for very early/early hepatocellular carcinoma (HCC) in patients who are candidates for both remains controversial. The aim of this study was to determine if the newly-developed Albumin-Bilirubin (ALBI) grade might help in treatment selections and to evaluate the survival of patients treated with liver resection and radiofrequency ablation (RFA). METHODS: Patients with BCLC stage 0/A HCC who were treated with curative liver resection and RFA from 2003 to 2013 were included...
August 11, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28807242/efficacy-and-safety-of-combination-therapy-of-chemoembolization-and-radiofrequency-ablation-with-different-time-intervals-for-hepatocellular-carcinoma-patients
#6
Yue-Min Feng, Xing Wang, Le Wang, Xiao-Wen Ma, Hao Wu, Hao-Ran Bu, Xiao-Yu Xie, Jian-Ni Qi, Qiang Zhu
BACKGROUND AND OBJECTIVES: Combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) has become an effective alternative therapy for hepatocellular carcinoma (HCC). In clinical practice, the choice of time interval between TACE and RFA is a key point for curative effect, but optimal time interval is uncertain in guidelines. We aim to explore the optimal time interval for HCC patients of Child-Pugh classification A or B. METHODS: Two hundred and thirty-three HCC patients of Child A or B who had undergone TACE and RFA were enrolled and divided into seven groups according to different time intervals (1-7weeks)...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28799842/midterm-safety-and-efficacy-of-irreversible-electroporation-of-malignant-liver-tumors-located-close-to-major-portal-or-hepatic-veins
#7
Martina Distelmaier, Alexandra Barabasch, Philipp Heil, Nils A Kraemer, Peter Isfort, Sebastian Keil, Christiane K Kuhl, Philipp Bruners
Purpose To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of hepatic tumors not suitable for thermal ablation (radiofrequency ablation [RFA] or microwave ablation). Materials and Methods This was an institutional review board-approved prospective study in 29 patients (15 men, 14 women; mean age, 63 years ± 12 [standard deviation]) with 43 primary (n = 8) or secondary (n = 35) malignant liver tumors who underwent computed tomography (CT)-guided IRE. All target tumors were located immediately adjacent to major hepatic veins, portal veins, or both; thus, they were not considered suitable for RFA or microwave ablation...
August 11, 2017: Radiology
https://www.readbyqxmd.com/read/28797997/hepatocellular-carcinoma-peritoneal-metastasis-role-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec
#8
John Spiliotis, Georgios Nikolaou, Nikolaos Kopanakis, Dimitra Vassiliadou, Alexios Terra, Elias Efstathiou
INTRODUCTION: Peritoneal dissemination of hepatocellular carcinoma (HCC) is a rare presentation with an incidence of 2-6%. The most common cause of peritoneal deposits is a ruptured HCC that results in tumor spillage into the peritoneal cavity. The overall incidence of spontaneous ruptures of HCC ranges from 5 to 15% and carries a high mortality rate of up to 50%. Other factors influencing peritoneal dissemination are the lymph node metastasis and the direct diaphragmatic invasion and there is no significant association with past history of FNAB, or percutaneous RFA or ethanol injection and lung or adrenal metastasis...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28797677/emergence-of-atrioventricular-nodal-reentry-tachycardia-after-surgical-or-catheter-ablation-for-atrial-fibrillation-are-we-creating-the-arrhythmia-substrate
#9
Jorge Romero, Saurabh Kumar, Fujii Akira, David F Briceño, Usha B Tedrow, Laurence Epstein, Roy John, William G Stevenson, Gregory F Michaud
BACKGROUND: Atrioventricular nodal reentry tachycardia (AVNRT) is common in adults and often involves reentry through two or more AV nodal-atrial connections. Although AVNRT can be a trigger for atrial fibrillation (AF), we have observed new onset AVNRT after AF ablation procedures. OBJECTIVE: To determine whether ablation involving the septum or proximal coronary sinus during AF ablation may create a substrate favorable for AVNRT METHODS: Cases of ablation for persistent AF who required a repeat ablation procedure between 2009 to 2016 were reviewed for diagnosis of AVNRT...
August 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28795996/initial-alpha-fetoprotein-response-predicts-prognosis-in-hepatitis-b-related-solitary-hcc-patients-after-radiofrequency-ablation
#10
Su Jong Yu, Jee Hye Kwon, Won Kim, Jung-Hwan Yoon, Jeong Min Lee, Jae Young Lee, Eun Ju Cho, Jeong-Hoon Lee, Hwi Young Kim, Yong Jin Jung, Yoon Jun Kim
BACKGROUND: Radiofrequency ablation (RFA) is effective for early-stage hepatocellular carcinoma but recurrence is problem. GOALS: To identify prognostic factors including alpha-fetoprotein (AFP) for overall survival and intrahepatic recurrence after RFA. PATIENTS AND METHODS: Not only naïve but also previously treated patients with solitary hepatitis B virus-related hepatocellular carcinoma <5 cm were prospectively enrolled and a ≥50% decrease from baseline to 1 month after RFA was defined as an initial AFP response...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28791798/cost-effectiveness-analysis-of-potentially-curative-and-combination-treatments-for-hepatocellular-carcinoma-with-person-level-data-in-a-canadian-setting
#11
Hla-Hla Thein, Wanrudee Isaranuwatchai, Yao Qiao, Kenny Wong, Gonzalo Sapisochin, Kelvin K W Chan, Eric M Yoshida, Craig C Earle
Patients with early-stage hepatocellular carcinoma (HCC) are potential candidates for curative treatments such as radiofrequency ablation (RFA), surgical resection (SR), or liver transplantation (LT), which have demonstrated a significant survival benefit. We aimed to estimate the cost-effectiveness of curative and combination treatment strategies among patients diagnosed with HCC during 2002-2010. This study used Ontario Cancer Registry-linked administrative data to estimate effectiveness and costs (2013 USD) of the treatment strategies from the healthcare payer's perspective...
August 8, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28773005/implant-stability-of-biological-hydroxyapatites-used-in-dentistry
#12
Maria Piedad Ramírez Fernández, Sergio A Gehrke, Patricia Mazón, Jose L Calvo-Guirado, Piedad N De Aza
The aim of the present study was to monitor implant stability after sinus floor elevation with two biomaterials during the first six months of healing by resonance frequency analysis (RFA), and how physico-chemical properties affect the implant stability quotient (ISQ) at the placement and healing sites. Bilateral maxillary sinus augmentation was performed in 10 patients in a split-mouth design using a bobine HA (BBM) as a control and porcine HA (PBM). Six months after sinus lifting, 60 implants were placed in the posterior maxilla...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28770555/efficacy-of-liquid-nitrogen-cryotherapy-for-barrett-s-esophagus-after-endoscopic-resection-of-intramucosal-cancer-a-multicenter-study
#13
Arvind J Trindade, Douglas K Pleskow, Neil Sengupta, Shivangi Kothari, Sumant Inamdar, Joshua Berkowitz, Vivek Kaul
BACKGROUND AND AIM: Liquid nitrogen cryotherapy (LNC) allows increased depth of ablation compared to radiofrequency ablation (RFA) in Barrett's esophagus (BE). Expert centers may use LNC over RFA to ablate Barrett's esophagus after endoscopic resection of intramucosal cancer (IMCA). The aim of our study was to: 1) evaluate the safety and efficacy of LNC ablation in patients with BE and IMCA and 2) to evaluate the progression to invasive disease despite therapy. METHODS: This was a multicenter, retrospective study of consecutive patients with BE who received LNC following endoscopic mucosal resection (EMR) of IMCA...
August 2, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28768450/outcome-of-dichorionic-triamniotic-triplet-the-experience-from-an-emerging-fetal-therapy-center
#14
Luming Sun, Gang Zou, Fenhe Zhou, Yingjun Yang, Dick Oepkes, Tao Duan
OBJECTIVES: To report a cohort of dichorionic triamniotic (DCTA) triplets with access to contemporary fetal interventions. DESIGN: Prospective study. SETTING: A regional referral center for the diagnosis and management of complicated multiple pregnancies. POPULATION: All DCTA triplets receiving consultation and prenatal care at our center from 2010 to 2015. METHODS: The following management alternatives for DCTA were offered: 1) expectant management; 2) reduction of 1 or 2 fetus of the monochorionic component using radio frequency ablation (RFA) after 16 weeks or potassium chloride (KCL) before 16 weeks, respectively; 3) reduction of the isolated fetus using KCL before 16 weeks...
August 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28766106/a-piecewise-function-of-resistivity-of-liver-determining-parameters-with-finite-element-analysis-of-radiofrequency-ablation
#15
Ricardo Possebon, Yansheng Jiang, Stefaan Mulier, Chong Wang, Feng Chen, Yuanbo Feng, Yicheng Ni
Radiofrequency ablation (RFA) is a widely used thermal treatment for liver tumors. Knowledge about the resistivity of liver is a prerequisite for the predictability of producible thermo-necrosis with RFA. Most research to date has focused on performing specific experiments to determine the resistivity of a given liver. This work aims to determine the resistivity from the time course of impedance obtained in RFA. We assume that the liver resistivity obeys a piecewise function of temperature. We determine in this work the means and standard derivations of parameters in the resistivity function with finite element analysis of ex vivo bipolar RFA...
August 2, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28766023/how-i-do-it-optimizing-radiofrequency-ablation-in-spinal-metastases-using-ict-and-navigation
#16
Pujan Kavakebi, C F Freyschlag, C Thomé
BACKGROUND: Exact positioning of the radiofrequency ablation (RFA) probe for tumor treatment under fluoroscopic guidance can be difficult because of potentially small inaccessible lesions and the radiation dose to the medical staff in RFA. In addition, vertebroplasty (VP) can be significantly high. METHOD: Description and workflow of RFA in spinal metastasis using iCT (intraoperative computed tomography) and 3D-navigation-based probe placement followed by VP. CONCLUSION: RFA and VP can be successfully combined with iCT-based navigation, which leads to a reduction of radiation to the staff and optimal probe positioning due to 3D navigation...
August 1, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28765087/circardian-variability-patterns-predict-and-guide-premature-ventricular-contraction-ablation-procedural-inducibility-and-outcomes
#17
David Hamon, Guillaume Abehsira, Kai Gu, Albert Liu, Marie Blaye-Felice Sadron, Sophie Billet, Thomas Kambur, Mohammed Amer Swid, Noel G Boyle, Gopi Dandamudi, Philippe Maury, Minglong Chen, John M Miller, Nicolas Lellouche, Kalyanam Shivkumar, Jason S Bradfield
BACKGROUND: Infrequent intra-procedural premature ventricular complexes (PVCs) may impede radiofrequency catheter ablation (RFA) outcome and pharmacological induction is unpredictable. OBJECTIVE: To determine whether PVC circadian variation could help predict drug response. METHODS: Consecutive patients referred for RFA with detailed Holter monitoring and frequent monomorphic PVCs were included. Patients were divided into 3 groups based on hourly PVC count relationship to corresponding mean HR during each of the 24 hours on Holter: fast-HR-dependent PVC (F-HR-PVC) type for a positive correlation (Pearson, P<0...
July 29, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28761039/atrio-esophageal-fistula-a-case-series-and-literature-review
#18
Craig A Schuring, Luke J Mountjoy, Ashley B Priaulx, Robert J Schneider, Hayden L Smith, Geoffrey C Wall, Dipen Kadaria, Amik Sodhi
BACKGROUND Percutaneous catheter radiofrequency ablation (RFA) and cryoablation of the left atrium and pulmonary vein ostia have become successful therapeutic modalities in the management of atrial fibrillation. Atrio-esophageal fistula is a rare complication. Awareness of complication risk is imperative because without prompt diagnosis and urgent surgical intervention, the outcome is often fatal. We present 3 cases of atrio-esophageal fistula following percutaneous catheter radiofrequency ablation (RFA). CASE REPORT Case 1: A 72-year old white male presented 27 days after percutaneous RFA for atrial fibrillation with fever, altered mental status, and melena...
August 1, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28755240/bridging-to-liver-transplantation-in-hcc-patients
#19
REVIEW
Dagmar Kollmann, Nazia Selzner, Markus Selzner
BACKGROUND: Liver transplantation (LT) is the only cure for patients diagnosed with unresectable hepatocellular carcinoma (HCC), and HCC has become the leading indication for LT in the USA. The shortage of liver grafts results in a significant waiting time for LT with the risk of tumour progression. Treating HCCs during the waiting time prior to transplantation (bridging therapy) is an attractive strategy to reduce the risk of exceeding the tumour criteria for transplantation. Studies on bridging therapy are heterogenous and due to ethical issues, mostly of retrospective design...
July 28, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28749166/ablative-safety-margin-depicted-by-fusion-imaging-with-post-treatment-contrast-enhanced-ultrasound-and-pre-treatment-cect-cemri-after-radiofrequency-ablation-for-liver-cancers
#20
Xiao-Wan Bo, Hui-Xiong Xu, Le-Hang Guo, Li-Ping Sun, Xiao-Long Li, Chong-Ke Zhao, Ya-Ping He, Bo-Ji Liu, Dan-Dan Li, Kun Zhang, Dan Wang
OBJECTIVES: To evaluate the value of fusion imaging with post-treatment contrast-enhanced ultrasound (CEUS) and pre-treatment contrast-enhanced computed tomography/magnetic resonance imaging (CECT/CEMRI) in evaluating ablative safety margin after percutaneous ultrasound (US)-guided radiofrequency ablation (RFA) for liver cancers. METHODS: 34 consecutive patients with 47 liver lesions who had undergone RFA were included. Fusion imaging with post-treatment CEUS and pre-treatment CECT/CEMRI was carried out to evaluate local treatment response and ablative safety margin within 1-3 days after RFA...
July 27, 2017: British Journal of Radiology
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