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https://www.readbyqxmd.com/read/28431129/cooled-radiofrequency-ablation-of-the-genicular-nerves-for-chronic-pain-due-to-knee-osteoarthritis-six-month-outcomes
#1
Zachary L McCormick, Marc Korn, Rajiv Reddy, Austin Marcolina, David Dayanim, Ryan Mattie, Daniel Cushman, Meghan Bhave, Robert J McCarthy, Dost Khan, Geeta Nagpal, David R Walega
Objective. : Determine outcomes of cooled radiofrequency ablation (C-RFA) of the genicular nerves for treatment of chronic knee pain due to osteoarthritis (OA). Design. : Cross-sectional survey. Setting.:  Academic pain medicine center. Subjects.:  Consecutive patients with knee OA and 50% or greater pain relief following genicular nerve blocks who underwent genicular nerve C-RFA. Methods.:  Survey administration six or more months after C-RFA...
April 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28429512/tailored-approach-for-management-of-ventricular-tachycardia-in-cardiac-sarcoidosis
#2
Sachin Yalagudri, Ngwe Zin Thu, Soumen Devidutta, Daljeet Saggu, Ajit Thachil, Sridevi Chennapragada, Calambur Narasimhan
INTRODUCTION: Treating ventricular tachycardia (VT) in patients with cardiac sarcoidosis (CS) is challenging as patients present in different phase of the disease (inflammatory, scar or sometimes both). A customized approach to treatment is required for better outcomes. We describe our experience in the management of VT in CS based on the phase of the disease. METHODS AND RESULTS: Patients were considered to have myocardial inflammation if there was an increased myocardial (18) Fluoro Deoxy Glucose (FDG) uptake in PET-CT scan of the chest (n=14)...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28429047/therapeutic-outcome-of-ct-guided-radiofrequency-ablation-in-patients-with-osteoid-osteoma
#3
Louis Lassalle, R Campagna, G Corcos, A Babinet, F Larousserie, J Stephanazzi, A Feydy
OBJECTIVE: To assess the long-term outcome of computed tomography-guided radiofrequency ablation (CT-guided RFA) in patients with suspected osteoid osteoma (OO). MATERIALS AND METHODS: Single-center retrospective study. Patients with clinical suspicion and imaging diagnosis of osteoid osteoma were treated by CT-guided RFA using the same device with either a 7- or 10-mm active tip electrode. Specific precautions were applied in case of articular or spinal OO. Patients were contacted by phone to evaluate the long-term outcome in terms of pain, ability to perform daily activities (including sports), and long-term complications...
April 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28423214/plasmodium-falciparum-otu-like-cysteine-protease-pfotu-is-essential-for-apicoplast-homeostasis-and-associates-with-non-canonical-role-of-atg8
#4
Gaurav Datta, Mohammad E Hossain, Mohd Asad, Sumit Rathore, Asif Mohmmed
The metabolic pathways associated with the mitochondrion and the apicoplast in Plasmodium, two parasite organelles of prokaryotic origin, are considered as suitable drug targets. In the present study, we have identified functional role of a novel OTU domain containing cysteine protease of Plasmodium falciparum (PfOTU). A C-terminal regulatable fluorescent affinity (RFA) tag on native protein was utilized for its localization and functional characterization. Detailed studies showed vesicular localization of PfOTU, and its association with the apicoplast...
April 18, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28421454/quality-indicators-in-endoscopic-ablation-for-barrett-s-esophagus
#5
REVIEW
Samuel Han, Sachin Wani
Barrett's esophagus (BE) is a well-established premalignant condition for esophageal adenocarcinoma (EAC); a cancer that is associated with a poor 5-year survival rate. Several strategies have been explored in the context of reducing the burden of EAC. Endoscopic eradication therapy (EET) is considered the standard of care for the management of patients with BE with dysplasia and early neoplasia; a practice that has been endorsed by all gastroenterology societal guidelines. The effectiveness of EET has been demonstrated in multiple studies and contemporary management includes a combination of endoscopic mucosal resection (EMR) of all visible lesions followed by eradication of the remaining BE using ablative techniques of which radiofrequency ablation (RFA) has the best evidence supporting effectiveness and safety...
April 18, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28417355/radiofrequency-versus-microwave-ablation-for-treatment-of-the-lung-tumours-lumira-lung-microwave-radiofrequency-randomized-trial
#6
RANDOMIZED CONTROLLED TRIAL
M Macchi, M P Belfiore, C Floridi, N Serra, G Belfiore, L Carmignani, R F Grasso, E Mazza, C Pusceddu, L Brunese, G Carrafiello
The LUMIRA trial evaluated the effectiveness of radiofrequency (RFA) and microwave ablation (MWA) in lung tumours ablation and defining more precisely their fields of application. It is a controlled prospective multi-centre random trial with 1:1 randomization. Fifty-two patients in stage IV disease (15 females and 37 males, mean age 69 y.o., range 40-87) were included. We randomized the patients in two different subgroups: MWA group and RFA group. For each group, we evaluated the technical and clinical success, the overall survival and complication rate...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28413650/clinical-features-of-hemodialysis-patients-treated-for-hepatocellular-carcinoma-comparison-between-resection-and-radiofrequency-ablation
#7
Atsushi Hiraoka, Takashi Kumada, Kojiro Michitaka, Hidenori Toyoda, Toshifumi Tada, Koichi Takaguchi, Kunihiko Tsuji, Ei Itobayashi, Daichi Takizawa, Masashi Hirooka, Yohei Koizumi, Hironori Ochi, Koji Joko, Yoshiyasu Kisaka, Yuko Shimizu, Kazuto Tajiri, Joji Tani, Tatsuya Taniguchi, Akiko Toshimori, Shinichi Fujioka
There is no consensus regarding which therapeutic option is better and/or safer for treating hemodialysis (HD) patients with hepatocellular carcinoma (HCC). The present study compared surgical resection (Hx) and radiofrequency ablation (RFA) with regard to therapeutic efficacy in HD patients with HCC. Of 108 HD patients with naïve HCC treated at 15 institutions between 1988 and 2014 enrolled in the present study, 58 fulfilled the up-to-7 criteria [7 as the sum of the size of the largest tumor (cm) and the number of tumors] and were treated with Hx (n=23) or RFA (n=35); their clinical features, complications and prognosis were assessed...
April 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28411877/combined-resection-and-radiofrequency-ablation-versus-transarterial-embolization-for-intermediate-stage-hepatocellular-carcinoma-a-propensity-score-matching-study
#8
Wendell Espinosa, Yueh-Wei Liu, Chih-Chi Wang, Chih-Che Lin, Jing-Houng Wang, Sheng-Nan Lu, Chao-Hung Hung
BACKGROUND/PURPOSE: This study aimed to compare the outcomes of combined hepatic resection (HR) plus intraoperative radiofrequency ablation (RFA) and transarterial embolization (TAE) for Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) in case-controlled patient groups using the propensity score. METHODS: A total of 179 patients with multifocal HCC treated with HR plus RFA (n = 26) or TAE (n = 153) were retrospectively studied. All patients were classified as BCLC stage B and Child-Pugh class A...
April 13, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28411697/veclose-trial-12-month-outcomes-of-cyanoacrylate-closure-versus-radiofrequency-ablation-for-incompetent-great-saphenous-veins
#9
Nick Morrison, Kathleen Gibson, Michael Vasquez, Robert Weiss, Daniel Cher, Monte Madsen, Andrew Jones
OBJECTIVE: Endovenous cyanoacrylate closure (CAC) is a new U.S. Food and Drug Administration-approved therapy for treatment of clinically symptomatic venous reflux in saphenous veins. The device is indicated for the permanent closure of lower extremity superficial truncal veins, such as the great saphenous vein (GSV). Early results from a randomized trial of CAC have been reported previously. Herein we report 1-year outcomes. METHODS: There were 222 subjects with symptomatic GSV incompetence randomly assigned to receive either CAC (n = 108) or radiofrequency ablation (RFA; n = 114)...
May 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28410102/scanned-three-dimensional-intracardiac-arfi-and-swei-for-imaging-radiofrequency-ablation-lesions
#10
Peter Hollender, Lily Kuo, Virginia Chen, Stephanie Eyerly, Patrick Wolf, Gregg Trahey
Radiofrequency ablation (RFA) is used to locally disrupt electrical propagation in myocardium and treat arrhythmias, and direct visualization of ablation lesions by acoustic radiation force methods may benefit RFA procedures. This work compares four imaging modalities, B-Mode, ARFI, STL-SWEI and MTL-SWEI, in their ability to resolve RFA lesions in four ex vivo experiments. Ablation lesions are shown to be marked by at least a local halving of ARFI displacements and doubling of shear wave speeds. In a controlled ablation of ex vivo porcine and canine cardiac tissue, STL-SWEI and ARFI are shown to have similar CNR, better than MTL-SWEI and B-Mode...
April 7, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28409546/clinical-correlation-with-failure-of-endovenous-therapy-for-leg-swelling
#11
Ahmad Alsheekh, Anil Hingorani, Natalie Marks, Yuriy Ostrozhynskyy, Enrico Ascher
Background The development and use of minimally invasive procedures provide improved options for the management of symptoms of chronic venous insufficiency. While many patients with iliac venous occlusive disease and superficial venous insufficiency improve with combined iliac venous stenting and correction of superficial venous reflux, some patients have symptoms which persist. The goal of this study was to identify clinical factors related to persistent symptoms in patients with leg swelling after treatment of both iliac vein stenting and thermal ablation...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28405317/changes-in-gene-expression-of-neo-squamous-mucosa-after-endoscopic-treatment-for-dysplastic-barrett-s-esophagus-and-intramucosal-adenocarcinoma
#12
Angelique Levert-Mignon, Michael J Bourke, Sarah J Lord, Andrew C Taylor, Antony R Wettstein, Melanie Edwards, Natalia K Botelho, Rebecca Sonson, Chatura Jayasekera, Oliver M Fisher, Melissa L Thomas, Finlay Macrae, Damian J Hussey, David I Watson, Reginald V Lord
BACKGROUND: Endoscopic therapy, including by radiofrequency ablation (RFA) or endoscopic mucosal resection (EMR), is first line treatment for Barrett's esophagus (BE) with high-grade dysplasia (HGD) or intramucosal cancer (IMC) and may be appropriate for some patients with low-grade dysplasia (LGD). OBJECTIVE: The purpose of this study was to investigate the molecular effects of endotherapy. METHODS: mRNA expression of 16 genes significantly associated with different BE stages was measured in paired pre-treatment BE tissues and post-treatment neo-squamous biopsies from 36 patients treated by RFA (19 patients, 3 IMC, 4 HGD, 12 LGD) or EMR (17 patients, 4 IMC, 13 HGD)...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28402124/percutaneous-radiofrequency-ablation-of-hepatocellular-carcinoma-in-cirrhosis-analysis-of-complications-in-a-single-center-over-20-years
#13
Antonio Giorgio, Maria Gabriella Merola, Luca Montesarchio, Francesca Merola, Pietro Gatti, Carmine Coppola, Valentina Giorgio, Giorgio Calisti
OBJECTIVES: To report on our 20 years' experience on complications after Radiofrequency Ablation (RFA) of Hepatocellular Carcinoma (HCC) in cirrhotic patients. METHODS: From 1994 to 2014, 1787 RFA procedures were performed percutaneously in 1162 cirrhotic patients (852 Child A and 310 Child B) with HCC nodules (1.2-7cm), PT>50%, platelet count of 50.000mm3 and total Bilirubin ranging from 0,80 to 4.5mg/dl. In 67 patients RFA was performed on both intraparenchymal HCC nodule and tumor thrombus extended in the main portal vein and/or its branches...
April 12, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28397974/genome-resequencing-analysis-of-salmonella-typhimurium-lt-2-strains-ta98-and-ta100-for-the-establishment-of-a-next-generation-sequencing-based-mutagenicity-assay
#14
Shoji Matsumura, Yuichi Ito, Osamu Morita, Hiroshi Honda
Next-generation sequencing (NGS) is a potentially useful technology to achieve a more precise evaluation of chemical mutagenicity. To establish NGS-based mutagenicity assays, which enable the direct detection of chemically induced mutations in a whole genome manner, the selection of appropriate biological resources and their precise genome sequences are essential. Here, we performed genome re-sequencing analyses of Salmonella typhimurium LT-2 strains TA98 and TA100, which have been frequently used in mutagenicity assays...
April 11, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28396723/laser-ablation-of-liver-tumors-an-ancillary-technique-or-an-alternative-to-radiofrequency-and-microwave
#15
EDITORIAL
Sergio Sartori, Francesca Di Vece, Francesca Ermili, Paola Tombesi
Radiofrequency ablation (RFA) is currently the most popular and used ablation modality for the treatment of non surgical patients with primary and secondary liver tumors, but in the last years microwave ablation (MWA) is being technically improved and widely rediscovered for clinical use. Laser thermal ablation (LTA) is by far less investigated and used than RFA and MWA, but the available data on its effectiveness and safety are quite good and comparable to those of RFA and MWA. All the three hyperthermia-based ablative techniques, when performed by skilled operators, can successfully treat all liver tumors eligible for thermal ablation, and to date in most centers of interventional oncology or interventional radiology the choice of the technique usually depends on the physician's preference and experience, or technical availability...
March 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28392205/radiofrequency-vs-microwave-ablation-after-neoadjuvant-transarterial-bland-and-drug-eluting-microsphere-chembolization-for-the-treatment-of-hepatocellular-carcinoma
#16
Lindsay M Thornton, Roniel Cabrera, Melissa Kapp, Michael Lazarowicz, Jeffrey D Vogel, Beau B Toskich
AIM: To retrospectively compare the initial response, local recurrence, and complication rates of radiofrequency ablation (RFA) vs microwave ablation (MWA) when combined with neoadjuvant bland transarterial embolization (TAE) or drug-eluting microsphere chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). METHODS: A total of 35 subjects with Barcelona Clinic Liver Cancer (BCLC) very early and early-stage HCC (range: 1.2-4.1cm) underwent TAE (23) or TACE (12) with RFA (15) or microwave ablation (MWA) (20) from January 2009 to June 2015 as either definitive therapy or a bridge to transplant...
February 20, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28391423/image-guided-thermal-ablative-therapies-in-the-treatment-of-sarcoma
#17
REVIEW
Scott M Thompson, John J Schmitz, Grant D Schmit, Matthew R Callstrom, Anil Nicholas Kurup
Percutaneous thermal ablation, including microwave ablation (MWA), radiofrequency ablation (RFA), and cryoablation, is a well-established focal treatment option for primary and metastatic malignancies. While published literature specific to ablation of sarcomas is relatively lacking compared with non-sarcomatous malignancies, what is available is promising. In situations where a focal treatment option is desired, strong consideration should be given to percutaneous thermal ablation, in addition to surgery and radiation therapy...
April 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28391383/percutaneous-radiofrequency-ablation-for-spinal-osteoid-osteoma-and-osteoblastoma
#18
Ben Wang, Song Bo Han, Liang Jiang, Hui Shu Yuan, Chen Liu, Bin Zhu, Zhong Jun Liu, Xiao Guang Liu
PURPOSES: We sought to verify the efficacy and safety of RFA in spinal OO and osteoblastomas (OB) (Enneking Stage 2, S2). METHODS: We retrospectively reviewed patients treated in our hospital. Surgical resection was indicated for Enneking Stage 3 OB. RFA indications for spinal OO and OB (S2) were no neurological deficits, complete bone cortex around the lesion on computed tomography (CT), and cerebrospinal fluid between a lesion and the spinal cord/nerve root on magnetic resonance imaging...
April 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28385727/multicenter-clinical-and-imaging-evaluation-of-targeted-radiofrequency-ablation-t-rfa-and-cement-augmentation-of-neoplastic-vertebral-lesions
#19
Melinda Reyes, Mark Georgy, Lorenzo Brook, Orlando Ortiz, Allan Brook, Vikas Agarwal, Mario Muto, Luigi Manfre, Stefano Marcia, Bassem A Georgy
BACKGROUND: Treatment of spinal metastatic lesions by radiofrequency ablation (RFA) before cementation can potentially help in local tumor control and pain relief. This is often limited by access and tumor location. This study reports multicenter clinical and imaging outcomes following targeted RFA (t-RFA) and cement augmentation in neoplastic lesions of the spine. MATERIAL AND METHODS: A retrospective multicenter study of 49 patients with 72 painful vertebral lesions, evaluated for clinical and imaging outcomes following RFA and cement augmentation of spinal metastatic lesions, was undertaken...
April 6, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28384223/evaluation-of-accuracy-and-precision-of-ct-guidance-in-radiofrequency-ablation-for-osteoid-osteoma-in-86-patients
#20
H Nijland, J G Gerbers, S K Bulstra, J Overbosch, M Stevens, P C Jutte
BACKGROUND AND PURPOSE: Osteoid osteoma is a benign skeletal tumour that accounts for 2-3% of all bone tumours. The male-to-female ratio is around 4:1 and it predominates in children and young adults. The most common symptom is pain, frequently at night-time. Historically the main form of treatment has been surgical excision. With the development of Radiofrequency Ablation (RFA) there is a percutaneus alternative. Success rates of RFA are lower but the main advantage is the minimal invasive character of the therapy and the low complication rate...
2017: PloS One
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