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https://www.readbyqxmd.com/read/29691986/association-of-atm-and-bmi-1-genetic-variation-with-breast-cancer-risk-in-han-chinese
#1
Li-Ling Yue, Fu-Chao Wang, Ming-Long Zhang, Dan Liu, Ping Chen, Qing-Bu Mei, Peng-Hui Li, Hong-Ming Pan, Li-Hong Zheng
We tested the hypothesis that genetic variation in ATM and BMI-1 genes can alter the risk of breast cancer through genotyping 6 variants among 524 breast cancer cases and 518 cancer-free controls of Han nationality. This was an observational, hospital-based, case-control association study. Analyses of single variant, linkage, haplotype, interaction and nomogram were performed. Risk was expressed as odds ratio (OR) and 95% confidence interval (CI). All studied variants were in the Hardy-Weinberg equilibrium and were not linked...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691980/glucocorticoids-modulate-multidrug-resistance-transporters-in-the-first-trimester-human-placenta
#2
Phetcharawan Lye, Enrrico Bloise, Lubna Nadeem, William Gibb, Stephen J Lye, Stephen G Matthews
The placental multidrug transporters, P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP, ABCG2) protect the foetus from exposure to maternally derived glucocorticoids, toxins and xenobiotics. During pregnancy, maternal glucocorticoid levels can be elevated by stress or exogenous administration. We hypothesized that glucocorticoids modulate the expression of ABCB1/P-gp and ABCG2/BCRP in the first trimester human placenta. Our objective was to examine whether dexamethasone (DEX) or cortisol modulate first trimester placental expression of multidrug transporters and determine whether cytotrophoblasts or the syncytiotrophoblast are/is responsible for mediating these effects...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691722/applying-new-magee-equations-for-predicting-the-oncotype-dx-recurrence-score
#3
Maher Sughayer, Rolla Alaaraj, Ahmad Alsughayer
BACKGROUND: Breast cancer is one of the most prevalent cancers in women. Oncotype Dx is a multi-gene assay frequently used to predict the recurrence risk for estrogen receptor-positive early breast cancer, with values < 18 considered low risk; ≥ 18 and ≤ 30, intermediate risk; and > 30, high risk. Patients at a high risk for recurrence are more likely to benefit from chemotherapy treatment. METHODS: In this study, clinicopathological parameters for 37 cases of early breast cancer with available Oncotype Dx results were used to estimate the recurrence score using the three new Magee equations...
April 24, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29691683/angio-3-a-10-residue-peptide-derived-from-human-plasminogen-kringle-3-suppresses-tumor-growth-in-mice-via-impeding-both-angiogenesis-and-vascular-permeability
#4
Shruthi Venugopal, Chieh Kao, Ritu Chandna, Konerirajapuram N Sulochana, Vivekanandan Subramanian, Mo Chen, R Manjunatha Kini, Ruowen Ge
Anti-angiogenesis therapy is an established therapeutic strategy for cancer. The endogenous angiogenic inhibitor angiostatin contains the first 3-4 kringle domains of plasminogen and inhibits both angiogenesis and vascular permeability. We present here a 10-residue peptide, Angio-3, derived from plasminogen kringle 3, which retains the functions of angiostatin in inhibiting both angiogenesis and vascular permeability. NMR studies indicate that Angio-3 holds a solution structure similar to the corresponding region of kringle 3...
April 24, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29691434/global-similarity-method-based-on-a-two-tier-random-walk-for-the-prediction-of-microrna-disease-association
#5
Min Chen, Bo Liao, Zejun Li
microRNAs (miRNAs) mutation and maladjustment are related to the occurrence and development of human diseases. Studies on disease-associated miRNA have contributed to disease diagnosis and treatment. To address the problems, such as low prediction accuracy and failure to predict the relationship between new miRNAs and diseases and so on, we design a Laplacian score of graphs to calculate the global similarity of networks and propose a Global Similarity method based on a Two-tier Random Walk for the prediction of miRNA-disease association (GSTRW) to reveal the correlation between miRNAs and diseases...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691399/a-serum-microrna-signature-predicts-trastuzumab-benefit-in-her2-positive-metastatic-breast-cancer-patients
#6
Huiping Li, Jiang Liu, Jianing Chen, Huiyun Wang, Linbin Yang, Fei Chen, Siting Fan, Jing Wang, Bin Shao, Dong Yin, Musheng Zeng, Mengfeng Li, Jun Li, Fengxi Su, Qiang Liu, Herui Yao, Shicheng Su, Erwei Song
Trastuzumab is a standard treatment for HER2-positive (HER2+ ) breast cancer, but some patients are refractory to the therapy. MicroRNAs (miRNAs) have been used to predict therapeutic effects for various cancers, but whether miRNAs can serve as biomarkers for HER2+ metastatic breast cancer (MBC) patients remains unclear. Using miRNA microarray, we identify 13 differentially expressed miRNAs in the serum of HER2+ MBC patients with distinct response to trastuzumab, and four miRNAs are selected to construct a signature to predict survival using LASSO model...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691364/primary-care-colorectal-cancer-screening-correlates-with-breast-cancer-screening-implications-for-colorectal-cancer-screening-improvement-interventions
#7
Jennifer M Weiss, Nancy Pandhi, Sally Kraft, Aaron Potvien, Pascale Carayon, Maureen A Smith
OBJECTIVE: National colorectal cancer (CRC) screening rates have plateaued. To optimize interventions targeting those unscreened, a better understanding is needed of how this preventive service fits in with multiple preventive and chronic care needs managed by primary care providers (PCPs). This study examines whether PCP practices of other preventive and chronic care needs correlate with CRC screening. METHODS: We performed a retrospective cohort study of 90 PCPs and 33,137 CRC screening-eligible patients...
April 25, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29691345/evaluating-mammographer-acceptance-of-mammorisk-software
#8
Jean Weigert, Nancy Cavanaugh, Talong Ju
PURPOSE: To evaluate mammographers' acceptance of the breast cancer risk assessment software tool MammoRisk (Statlife) in the clinical setting. METHODS: During a 6-month period, 1200 women undergoing routine mammography examinations at a regional, outpatient, comprehensive breast imaging center were assessed for breast cancer risk by mammographers who used the MammoRisk software. At the end of the 6-month period, the mammographers (N = 11) completed an 8-question survey on their willingness to the use of the software in the clinical setting...
March 2018: Radiologic Technology
https://www.readbyqxmd.com/read/29691252/high-usp6nl-levels-in-breast-cancer-sustain-chronic-akt-phosphorylation-and-glut1-stability-fueling-aerobic-glycolysis
#9
Daniele Avanzato, Emanuela Pupo, Nadia Ducano, Claudio Isella, Giovanni Bertalot, Chiara Luise, Salvatore Pece, Alejandra Bruna, Oscar M Rueda, Carlos Caldas, Pier Paolo Di Fiore, Anna Sapino, Letizia Lanzetti
USP6NL, also named RN-tre, is a GTPase activating protein (GAP) involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer (BC), mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosis in the METABRIC dataset, retaining prognostic value in multivariable analysis. High levels of USP6NL in BC cells delayed endocytosis and degradation of the epidermal growth factor receptor (EGFR), causing chronic AKT activation...
April 24, 2018: Cancer Research
https://www.readbyqxmd.com/read/29691196/clinical-characteristics-and-outcomes-of-older-women-with-breast-cancer-in-mexico
#10
Paula Cabrera-Galeana, Enrique Soto-Perez-de-Celis, Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, Claudia Arce-Salinas, Juan Matus-Santos, María Teresa Ramírez-Ugalde, Alberto Alvarado-Miranda, Abelardo Meneses-García, Fernando Lara-Medina, Juan Torres-Dominguez, Enrique Bargalló-Rocha, Alejandro Mohar
INTRODUCTION: Although the epidemiology of breast cancer in older women has been widely described before, little is known about the clinical characteristics and prognosis of older patients living in developing countries. Here, we studied older women with breast cancer treated at a public cancer center in Mexico City, and compared their outcomes with their younger counterparts. MATERIALS AND METHODS: We retrospectively analyzed a database of 5488 women treated for breast cancer at a single institution...
April 21, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29691126/outcome-and-prognostic-impact-of-surgical-staging-in-serous-tubal-intraepithelial-carcinoma-a-cohort-study-and-systematic-review
#11
N M A Van der Hoeven, K Van Wijk, S E Bonfrer, J J Beltman, L A Louwe, C D De Kroon, C J Van Asperen, K N Gaarenstroom
The optimal management of breast cancer susceptibility gene (BRCA)1/2 carriers with isolated serous tubal intraepithelial carcinoma (STIC) found at risk-reducing salpingo-oophorectomy (RRSO) is unclear. The prevalence of occult carcinoma and STIC in a consecutive series of BRCA1/2 carriers undergoing RRSO is reported. The outcome of staging procedures in BRCA1/2 carriers with isolated STIC at RRSO as well as the relationship between staging, chemotherapy treatment and risk of recurrence was assessed via a systematic review of the literature...
April 21, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29691123/a-computer-aided-detection-of-the-architectural-distortion-in-digital-mammograms-using-the-fractal-dimension-measurements-of-bemd
#12
Imad Zyout, Roberto Togneri
Achieving a high performance for the detection and characterization of architectural distortion in screening mammograms is important for an efficient breast cancer early detection. Viewing a mammogram image as a rough surface that can be described using the fractal theory is a well-recognized approach. This paper presents a new fractal-based computer-aided detection (CAD) algorithm for characterizing various breast tissues in screening mammograms with a particular focus on distinguishing between architectural distortion and normal breast parenchyma...
April 3, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29691075/estro-acrop-guideline-interstitial-multi-catheter-breast-brachytherapy-as-accelerated-partial-breast-irradiation-alone-or-as-boost-gec-estro-breast-cancer-working-group-practical-recommendations
#13
Vratislav Strnad, Tibor Major, Csaba Polgar, Michael Lotter, Jose-Luis Guinot, Cristina Gutierrez-Miguelez, Razvan Galalae, Erik Van Limbergen, Benjamin Guix, Peter Niehoff, Kristina Lössl, Jean-Michel Hannoun-Levi
PURPOSE: This consensus statement from the Breast Cancer Working Group of Groupe Européen de Curiethérapie of European Society for Radiotherapy and Oncology (GEC-ESTRO) aims at generating practical guidelines for multi-catheter image-guided brachytherapy in the conservative management of breast cancer patients used for either Accelerated Partial Breast Irradiation (APBI) or for a breast boost. METHODS: Recent advances in techniques of multi-catheter brachytherapy were summarized and all the relevant literature was reviewed by a panel of experts...
April 21, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29690887/relational-spirituality-and-quality-of-life-2007-to-2017-an-integrative-research-review
#14
REVIEW
Victor Counted, Adam Possamai, Tanya Meade
BACKGROUND: Despite the increasing number of evidence-based research on relational spirituality (RS) and quality of life (QoL) in medical-health research, little is known about the links between RS and QoL outcomes and the mechanisms by which RS aspects are functionally tied to QoL. OBJECTIVE: To determine how RS is perceived/positioned in relation to QoL, we (a) examined recent available data that identify and appraise the links between RS and QoL; (b) identified themes emerging from the association between RS and QoL, and (c) discussed the implications of the effects of RS on QoL outcomes...
April 24, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#15
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690858/effects-of-menopausal-symptoms-and-depression-on-the-quality-of-life-of-premenopausal-women-with-breast-cancer-in-korea
#16
Jeong Ae Han, So Young Choi, Seonah Lee
INTRODUCTION: As breast cancer survivors have increased, improving quality of life of the survivors becomes an important issue. The purpose of this study was to examine relationships among menopausal symptoms, depression, and quality of life and to identify the factors affecting the quality of life in premenopausal women with breast cancer. METHOD: This was a descriptive, correlational study using structured questionnaires for 90 premenopausal women with breast cancer attending the outpatient clinic of a tertiary hospital in Korea...
April 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29690801/a-link-between-expression-level-of-long-non-coding-rna-zfas1-in-breast-tissue-of-healthy-women-and-obesity
#17
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Mohammad Mehdi Naghizadeh, Zahra Zendehbad, Milad Bastami, Ziba Nariman-Saleh-Fam, Hosein Mansoori, Javad Tavakkoly-Bazzaz
BACKGROUND: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29690797/atezolizumab-for-the-treatment-of-breast-cancer
#18
Debora Basile, Giacomo Pelizzari, Maria Grazia Vitale, Camilla Lisanti, Marika Cinausero, Donatella Iacono, Fabio Puglisi
Breast cancer (BC) is the most common cancer diagnosed among women. The development of new personalized therapeutic strategies has reshaped the landscape in this field. However, BC is still the first cause of death among women. Interestingly, several preclinical studies and some clinical evidences are focused their attention on the role of immune system and immunotherapy on cancer control, also in BC. Areas covered: Usually, BC has been considered a not immunogenic tumor for its low mutational load. However, recent studies have evidenced that some subtypes, triple negative and HER-2 positive BC, are "hot" tumors, thus more immunogenic...
April 24, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29690765/miktoarm-amphiphilic-block-copolymer-with-singlet-oxygen-labile-stereospecific-%C3%AE-aminoacrylate-junction-synthesis-self-assembly-and-photodynamically-triggered-drug-release
#19
Gurusamy Saravanakumar, Hyeongmok Park, Jinhwan Kim, Dongsik Park, Swapan Pramanick, Dae Heon Kim, Won Jong Kim
Incorporation of a desired stimuli-responsive unit in a stereospecific manner at the specific location within a non-linear block copolymer architecture is a challenging task in synthetic polymer chemistry. Herein, we report a facile and versatile method to synthesize AB2 miktoarm block copolymers bearing a singlet oxygen (1O2)-labile regio and stereospecific -aminoacrylate linkage with 100% E-configuration at the junction via a combination of amino-yne click chemistry and ring opening polymerization. Using this strategy, a series of 1O2-responsive AB2 amphiphilic miktoarm copolymers composed of hydrophilic polyethylene glycol (PEG) as the A constituent and hydrophobic polycaprolactone (PCL) as the B constituent (MA-PEG-b-PCL2) was synthesized by varying the block length of PCL...
April 24, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29689710/esr1-and-pik3ca-mutational-status-in-serum-and-plasma-from-metastatic-breast-cancer-patients-a-comparative-study
#20
Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mai Tomiguchi, Aiko Sueta, Hirotaka Iwase
PURPOSE: Plasma and serum cell-free DNA (cfDNA) are useful sources of tumor DNA, but comparative investigations of the tumor mutational status between them are rare. METHODS: we performed droplet digital PCR assay for representative hotspot mutations in metastatic breast cancer (MBC) (ESR1 and PIK3CA) in serum and plasma cfDNA concurrently extracted from the blood of 33 estrogen receptor-positive MBC patients. RESULTS: ESR1 mutations in plasma cfDNA were found in 7 of the 33 patients; ESR1 mutations in serum cfDNA were detected in only one out of 7 patients with ESR1 mutations in plasma cfDNA...
April 7, 2018: Cancer Biomarkers: Section A of Disease Markers
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