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https://www.readbyqxmd.com/read/27908181/defining-and-assessing-an-anisotropic-delineation-margin-for-modern-radiotherapy
#1
L R Bell, E M Pogson, P E Metcalfe, L C Holloway
PURPOSE: Uncertainty in target volume delineation for modern radiotherapy impacts dosimetry and patient outcomes. Delineation uncertainty is generally overlooked in practice as a source of error, potentially since historically, other uncertainties have been the main focus. This work defined and assessed an anisotropic delineation margin in both polar and spherical coordinate systems in order to account for the spatially varying nature of this uncertainty using a whole breast radiotherapy cohort as a proof of concept...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#2
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27858093/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy
#3
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S Vaidya
INTRODUCTION: The use of targeted intraoperative radiotherapy (TARGIT-IORT) as a tumour bed boost during breast-conserving surgery (BCS) for breast cancer has been reported since 1998. We present its use in patients undergoing breast conservation following neoadjuvant therapy (NACT). METHOD: In this retrospective study involving 116 patients after NACT we compared outcomes of 61 patients who received a tumour bed boost with IORT during lumpectomy versus 55 patients treated in the previous 13 months with external (EBRT) boost...
November 17, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27842982/in-vivo-skin-dose-measurement-using-moskin-detectors-in-tangential-breast-radiotherapy
#4
W L Jong, N M Ung, J H D Wong, K H Ng, W Z Wan Ishak, R Abdul Malik, V C E Phua, D L Cutajar, P E Metcalfe, A B Rosenfeld, G F Ho
The purpose of this study is to measure patient skin dose in tangential breast radiotherapy. Treatment planning dose calculation algorithm such as Pencil Beam Convolution (PBC) and in vivo dosimetry techniques such as radiochromic film can be used to accurately monitor radiation doses at tissue depths, but they are inaccurate for skin dose measurement. A MOSFET-based (MOSkin) detector was used to measure skin dose in this study. Tangential breast radiotherapies ("bolus" and "no bolus") were simulated on an anthropomorphic phantom and the skin doses were measured...
November 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27825796/evaluation-of-acute-skin-toxicity-in-breast-radiotherapy-with-a-new-quantitative-approach
#5
Amparo González Sanchis, Luis Brualla González, Jose Luis Sánchez Carazo, Jose Carlos Gordo Partearroyo, Altea Esteve Martínez, Aurora Vicedo González, Jose Luis López Torrecilla
BACKGROUND AND PURPOSE: Current criteria to evaluate acute radiodermatitis are highly subjective so quantification of physiological parameters is needed. We describe a non-invasive method of assessing skin microcirculation in breast cancer patients treated with hypofractionated radiotherapy and correlate them with the CTCAE scale. METHODS: Prospective study of 63 patients where blood flow was measured with real-time laser Doppler flowmetry (LDF) at baseline, weekly, and 3-months post-radiotherapy...
November 5, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27741383/comparison-of-setup-accuracy-of-three-different-image-assessment-methods-for-tangential-breast-radiotherapy
#6
Vikneswary Batumalai, Penny Phan, Callie Choong, Lois Holloway, Geoff P Delaney
INTRODUCTION: To compare the differences in setup errors measured with electronic portal image (EPI) and cone-beam computed tomography (CBCT) in patients undergoing tangential breast radiotherapy (RT). Relationship between setup errors, body mass index (BMI) and breast size was assessed. METHODS: Twenty-five patients undergoing postoperative RT to the breast were consented for this study. Weekly CBCT scans were acquired and retrospectively registered to the planning CT in three dimensions, first using bony anatomy for bony registration (CBCT-B) and again using breast tissue outline for soft tissue registration (CBCT-S)...
December 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27741382/tangential-intensity-modulated-radiation-therapy-imrt-to-the-intact-breast
#7
Jenna Dean, Carmen J Hansen, Justin Westhuyzen, Brett Waller, Kirsty Turnbull, Maree Wood, Andrew Last
INTRODUCTION: Inverse-planned intensity modulated radiation therapy (IP-IMRT) has potential benefits over other techniques for tangential intact breast radiotherapy. Possible benefits include increased homogeneity, faster planning time, less inter-planner variability and lower doses to organs at risk (OAR). We therefore conducted a pilot study of previously treated intact breast patients to compare the current forward-planned 'field-in-field' technique (FP-IMRT) with an IP-IMRT alternative...
December 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27716875/advantage-of-deep-inspiration-breath-hold-in-left-sided-breast-cancer-patients-treated-with-3d-conformal-radiotherapy
#8
Luciana Lastrucci, Simona Borghesi, Silvia Bertocci, Chiara Gasperi, Andrea Rampini, Giovanna Buonfrate, Paola Pernici, Roberta De Majo, Pietro Giovanni Gennari
PURPOSE: To compare 3D-conformal radiotherapy (3D-CRT) treatment plans based on free-breathing (FB) and deep inspiration breath hold (DIBH) and investigated whether DIBH technique enables a decrease of cardiac left anterior descending coronary artery (LADCA) and lungs dose with respect to the FB. METHODS: Twenty-three left-sided breast cancer patients referred for breast radiotherapy were included. The planning target volume (PTV) encompassed the breast and organs at risk including heart, LADCA, lungs, and contralateral breast, which were contoured in FB and DIBH CT scans...
September 27, 2016: Tumori
https://www.readbyqxmd.com/read/27710100/a-randomised-control-trial-evaluating-fluorescent-ink-versus-dark-ink-tattoos-for-breast-radiotherapy
#9
Steven J Landeg, Anna M Kirby, Steven F Lee, Freddie Bartlett, Kumud Titmarsh, Ellen Donovan, Clare L Griffin, Lone Gothard, Imogen Locke, Helen A McNair
OBJECTIVES: The purpose of this UK study was to evaluate inter-fraction reproducibility and body image score when using Ultraviolet (UV) tattoos (not visible in ambient lighting) for external references during breast/chest wall radiotherapy and compare to conventional dark ink. METHODS: In this non-blinded, single centre, parallel group, randomised control trial, patients were allocated 1:1 to receive either conventional dark ink or UV ink tattoos using computer generated random blocks...
October 6, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27698590/dosimetric-feasibility-of-an-off-breast-isocenter-technique-for-whole-breast-cancer-radiotherapy
#10
Juan-Francisco Calvo-Ortega, Sandra Moragues, Miquel Pozo, Joan Casals
AIM: To investigate the viability of placing the treatment isocenter at the patient midline for breast cancer radiotherapy in order to avoid the risk of collisions during image-guided setup and treatment delivery. BACKGROUND: The use of kilovoltage orthogonal setup images has spread in last years in breast radiotherapy. There is a potential risk of an imaging system-patient collision when the isocenter is laterally placed. MATERIALS AND METHODS: Twenty IMRT plans designed by placing the isocenter within the breast volume ("plan_ref"), were retrospectively replanned by shifting the isocenter at the patient's midline ("plan_off-breast")...
November 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27681376/prospective-study-of-postoperative-whole-breast-radiotherapy-for-japanese-large-breasted-women-a-clinical-and-dosimetric-comparisons-between-supine-and-prone-positions-and-a-dose-measurement-using-a-breast-phantom
#11
Kana Takahashi, Madoka Morota, Yoshikazu Kagami, Hiroyuki Okamoto, Shuhei Sekii, Koji Inaba, Naoya Murakami, Hiroshi Igaki, Yoshinori Ito, Takashi Uno, Jun Itami
BACKGROUND: This prospective study aimed to compare dose volume histograms (DVH) of the breasts and organs at risk (OARs) of whole breast radiotherapy in the supine and prone positions, and frequency and severity of acute and late toxicities were analyzed. METHODS: Early-stage breast cancer patients with large breasts (Japanese bra size C or larger, or the widest measurements of the bust ≥ 95 cm) undergoing partial mastectomy participated in this study. CT-based treatment plans were made in each position, and various dosimetric parameters for the breast and OARs were calculated to compare the supine and prone radiotherapy plans...
September 29, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27666929/prolongation-of-overall-treatment-time-as-a-cause-of-treatment-failure-in-early-breast-cancer-an-analysis-of-the-uk-start-standardisation-of-breast-radiotherapy-trials-of-radiotherapy-fractionation
#12
Joanne S Haviland, Søren M Bentzen, Judith M Bliss, John R Yarnold
BACKGROUND: Tests of tumour treatment time effect in patients prescribed post-operative radiotherapy for early breast cancer have focussed on time to start of radiotherapy rather than overall treatment time. The START randomised trials of radiotherapy fractionation provide an opportunity to directly estimate the effect of treatment acceleration. METHODS: Between 1986 and 2002, a total of 5861 women with early breast cancer were recruited into the UK START pilot (START-P), START-A and START-B randomised trials...
September 22, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27614520/-establishing-margins-from-ctv-to-ptv-in-breast-cancer-treatment
#13
A Cabanne, U Schick, O Pradier, S Rivera
The benefit of postoperative radiotherapy for breast cancer both in terms of local control and overall survival is widely acknowledged. Today, technological advances in simulation imaging and positioning control enable the definition of new margins from CTV to PTV. Improvements in mathematical modeling of random and systematic errors impact the treatment plans. However, there is no universal absolute value to consistently determine the margins from CTV to PTV. It is down to each centre to assess and correct as much as possible uncertainties due to positioning and internal movements depending on techniques and methods used for the implementation of treatment and monitoring...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27614504/-what-is-the-role-of-intraoperative-radiotherapy-in-breast-cancer-treatment
#14
M Aumont
Breast-conserving surgery followed by whole breast postoperative irradiation is considered to be the current standard treatment for patients with early stage breast cancer. It allows an excellent local tumour control with 6% of local recurrence. Over the last years, partial breast radiotherapy has been developed to reduce treatment volume and duration. Intraoperative radiotherapy is one of the techniques. It offers an excellent delineation of the tumour bed and high normal tissue sparing. This purpose of this review is to describe the different intraoperative radiotherapy techniques available, to assess their potential clinical efficiency and tolerance, the recommendations for new practice with a selected population of patients and for future research...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27606932/who-benefits-from-a-tumor-bed-boost-after-whole-breast-radiotherapy
#15
Laurie W Cuttino, Charlotte Dai Kubicky
No abstract text is available yet for this article.
September 8, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27601955/risk-factors-for-seroma-evacuation-in-breast-cancer-patients-treated-with-intraoperative-radiotherapy
#16
Michał Falco, Bartłomiej Masojć, Magdalena Rolla, Agnieszka Czekała, Jolanta Pietruszewska, Agnieszka Rubik-Leszczyńska, Mirosław Lewocki, Magdalena Łukowiak, Andrzej Kram
BACKGROUND: Novel techniques in oncology provide new treatment opportunities but also introduce different patterns of side effects. Intraoperative radiotherapy (IORT) allows a shortened overall treatment time for early breast cancer either combined with whole breast radiotherapy (WBRT), or alone. Although the early side effects of IORT are well known, data on clinically important late side effects, which require medical intervention, are scarce. AIM: In this study, we analyze risk factors for seroma evacuation more than 6 months after IORT...
May 2016: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27592267/-respiratory-synchronization-and-breast-radiotherapy
#17
A Mège, A Ziouèche-Mottet, V Bodez, R Garcia, A Arnaud, G de Rauglaudre, N Pourel, B Chauvet
Adjuvant radiation therapy following breast cancer surgery continues to improve locoregional control and overall survival. But the success of highly targeted-conformal radiotherapy such as intensity-modulated techniques, can be compromised by respiratory motion. The intrafraction motion can potentially result in significant under- or overdose, and also expose organs at risk. This article summarizes the respiratory motion and its effects on imaging, dose calculation and dose delivery by radiotherapy for breast cancer...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27579712/mean-heart-dose-variation-over-a-course-of-breath-holding-breast-cancer-radiotherapy
#18
Nicolle Dunkerley, Frederick R Bartlett, Anna M Kirby, Philip M Evans, Ellen M Donovan
OBJECTIVES: The purpose of the work was to estimate the dose received by the heart throughout a course of breath holding breast radiotherapy. METHODS: 113 cone beam CT (CBCT) scans were acquired for 20 patients treated within the HeartSpare 1A study in which both an Active Breathing Control (ABC) device and a voluntary breath hold method (VBH) were used. Predicted mean heart doses were obtained from treatment plans. CBCT scans were imported into a treatment planning system, heart outlines defined, images registered to the CT planning scan and mean heart dose recorded...
August 31, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27579310/comprehensive-evaluation-of-personal-clinical-and-radiation-dosimetric-parameters-for-acute-skin-reaction-during-whole-breast-radiotherapy
#19
Dae Sik Yang, Jung Ae Lee, Won Sup Yoon, Nam Kwon Lee, Young Je Park, Suk Lee, Chul Yong Kim, Gil Soo Son
Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving surgery and adjuvant whole breast irradiation were retrospectively reviewed. All patients had both whole breast irradiation and boost to the tumour bed. Skin reaction was measured on the first day of boost therapy based on photography of the radiation field and medical records...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27542573/building-a-new-model-of-care-for-rapid-breast-radiotherapy-treatment-planning-evaluation-of-the-advanced-practice-radiation-therapist-in-cavity-delineation
#20
G Lee, R Dinniwell, F F Liu, A Fyles, K Han, T Conrad, W Levin, A Marshall, T G Purdie, C A Koch
AIMS: Breast radiotherapy treatment is commonly managed by a multidisciplinary team to ensure optimal delivery of care. We sought a new model of care whereby a clinical specialist radiation therapist (CSRT) delineates the cavity target for whole breast radiotherapy treatment planning and the radiation oncologist validates the contour during final plan review. This study evaluated the radiation oncologist's acceptance of these contours and identified characteristics of cavities suitable for CSRT-directed contouring...
August 16, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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