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https://www.readbyqxmd.com/read/29773535/should-patients-with-ductal-carcinoma-in-situ-be-treated-with-adjuvant-whole-breast-radiotherapy-after-breast-conservation-surgery
#1
Jessamy Bagenal, Nicola Roche, Gill Ross, Anna Kirby, David Dodwell
No abstract text is available yet for this article.
May 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29740971/target-position-reproducibility-in-left-breast-irradiation-with-deep-inspiration-breath-hold-using-multiple-optical-surface-control-points
#2
Aurora Fassi, Giovanni B Ivaldi, Paola Tabarelli de Fatis, Marco Liotta, Ilaria Meaglia, Patrizia Porcu, Lea Regolo, Marco Riboldi, Guido Baroni
The aim of this study was to investigate the use of 3D optical localization of multiple surface control points for deep inspiration breath-hold (DIBH) guidance in left-breast radiotherapy treatments. Ten left-breast cancer patients underwent whole-breast DIBH radiotherapy controlled by the Real-time Position Management (RPM) system. The reproducibility of the tumor bed (i.e., target) was assessed by the position of implanted clips, acquired through in-room kV imaging. Six to eight passive fiducials were positioned on the patients' thoraco-abdominal surface and localized intrafractionally by means of an infrared 3D optical tracking system...
May 8, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29696752/clinical-implementation-of-axb-from-aaa-for-breast-plan-quality-and-subvolume-analysis
#3
Alexandra Guebert, Leigh Conroy, Sarah Weppler, Majed Alghamdi, Jessica Conway, Lindsay Harper, Tien Phan, Ivo A Olivotto, Wendy L Smith, Sarah Quirk
PURPOSE: Two dose calculation algorithms are available in Varian Eclipse software: Anisotropic Analytical Algorithm (AAA) and Acuros External Beam (AXB). Many Varian Eclipse-based centers have access to AXB; however, a thorough understanding of how it will affect plan characteristics and, subsequently, clinical practice is necessary prior to implementation. We characterized the difference in breast plan quality between AXB and AAA for dissemination to clinicians during implementation...
April 25, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29678596/evaluation-of-acute-skin-toxicity-of-breast-radiotherapy-using-thermography-results-of-a-prospective-single-centre-trial
#4
O Maillot, N Leduc, V Atallah, P Escarmant, A Petit, S Belhomme, P Sargos, V Vinh-Hung
PURPOSE: Radiotherapy is a common adjuvant treatment of breast cancer. Acute radiation-induced dermatitis is a frequent side effect. We hypothesized whether it is possible to capture the increase of local temperature as a surrogate of the inflammatory state induced by radiotherapy. We designed a prospective, observational, single-centre study to acquire data on temperature rise in the treated breast during the course of radiotherapy, establish a possible association with the occurrence of dermatitis and investigate the predictive value of temperature increase in future occurrences of radiation-induced dermatitis...
April 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29670854/deep-inspiration-breath-hold-techniques-and-advantages-for-cardiac-sparing-during-breast-cancer-irradiation
#5
REVIEW
Carmen Bergom, Adam Currey, Nina Desai, An Tai, Jonathan B Strauss
Historically, heart dose from left-sided breast radiotherapy has been associated with a risk of cardiac injury. Data suggests that there is not a threshold for the deleterious effects from radiation on the heart. Over the past several years, advances in radiation delivery techniques have reduced cardiac morbidity due to treatment. Deep inspiration breath hold (DIBH) is a technique that takes advantage of a more favorable position of the heart during inspiration to minimize heart doses over a course of radiation therapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29651533/spatial-orientation-of-coronary-arteries-and-its-implication-for-breast-and-thoracic-radiotherapy-proposing-coronary-strip-as-a-new-organ-at-risk
#6
Anusheel Munshi, Nilaxi Khataniar, Biplab Sarkar, Moti Lal Bera, Bidhu Kalyan Mohanti
OBJECTIVES: Radiotherapy for breast cancer has been associated with various side effects including cardiac sequelae. Our study aimed to define the spatial arc of spread of coronary vessels in a radian angle. MATERIALS AND METHODS: We analysed the records of 51 CT coronary angiographies done in our hospital from January 2016 to July 2016. Left anterior descending (LAD) and right coronary (RC) were contoured for each patient. In each axial section, the radial spread of each artery was noted...
April 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29628633/dosimetric-comparison-of-treatment-plans-using-physical-wedge-and-enhanced-dynamic-wedge-for-the-planning-of-breast-radiotherapy
#7
Zhenia Gopalakrishnan, Raghuram K Nair, P Raghukumar, B Sarin
The aim of this study is to compare the physical wedge (PW) with enhanced dynamic wedge (EDW) to determine the difference in the dose distribution affecting the treated breast and the contralateral breast, lungs, heart, esophagus, spine, and surrounding skin in the radiotherapy of breast cancer. Computed tomography (CT) data sets of 30 breast cancer patients were selected from the database for the study. The treatment plans which were executed with PW were re-planned with EDW without changing the beam parameters...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29616366/de-escalation-of-breast-radiotherapy-after-conserving-surgery-in-low-risk-early-breast-cancer-patients
#8
REVIEW
Pierfrancesco Franco, Giuseppe Carlo Iorio, Sara Bartoncini, Mario Airoldi, Corrado De Sanctis, Isabella Castellano, Umberto Ricardi
The reduction in the burden related to treatment is becoming more and more important in modern oncology. Radiation therapy is a mainstay option in the postoperative setting for early breast cancer patients after breast-conserving surgery. Nowadays, different options are available to de-escalate radiotherapy in this scenario such as the use of hypofractionated whole-breast radiation, the selective delivery of the boost dose to the lumpectomy cavity, the introduction of accelerated partial breast irradiation and the omission of treatment in appropriately selected patients with low-risk features...
April 3, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29594228/vmat-radiation-induced-nausea-and-vomiting-in-adjuvant-breast-cancer-radiotherapy-the-incidental-effect-of-low-dose-bath-exposure
#9
G Lazzari, A Terlizzi, M G Leo, G Silvano
Background and purpose: To investigate the hypothesis on low-dose bath exposure related to radiation-induced nausea and vomiting (RINV) in adjuvant breast volumetric modulated arch therapy (VMAT). Methods and materials: A total of 106 consecutive breast cancer patients (pts) treated with adjuvant radiotherapy (RT) with VMAT from January 2013 to May 2016 were evaluated retrospectively. For each pt, a planning CT was reimported and the coeliac plexus and gastroesophageal junction with gastric mouth (GEJCPs) were contoured as a new organ at risk (OAR) in the upper abdominal area...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29576443/modifiable-risk-factors-for-acute-skin-toxicity-in-adjuvant-breast-radiotherapy-dosimetric-analysis-and-review-of-the-literature
#10
Lorna G Keenan, Naomi Lavan, Mary Dunne, Orla McArdle
Acute skin toxicity in adjuvant breast radiation can be reduced with modern radiotherapy (RT) techniques. However, having reviewed the literature, we found no dosimetric constraint for acute skin toxicity that would be applicable to modern RT planning. This study aimed to identify dosimetric factors that are associated with higher rates of acute skin toxicity. A retrospective review was carried out including women who received adjuvant forward-planned intensity-modulated radiotherapy (IMRT) after breast-conserving surgery...
March 23, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29536664/low-cost-kinect-version-2-imaging-system-for-breath-hold-monitoring-and-gating-proof-of-concept-study-for-breast-cancer-vmat-radiotherapy
#11
David M Edmunds, Lone Gothard, Komel Khabra, Anna Kirby, Poonam Madhale, Helen McNair, David Roberts, K K Tang, Richard Symonds-Tayler, Fatemeh Tahavori, Kevin Wells, Ellen Donovan
Voluntary inspiration breath hold (VIBH) for left breast cancer patients has been shown to be a safe and effective method of reducing radiation dose to the heart. Currently, VIBH protocol compliance is monitored visually. In this work, we establish whether it is possible to gate the delivery of radiation from an Elekta linac using the Microsoft Kinect version 2 (Kinect v2) depth sensor to measure a patient breathing signal. This would allow contactless monitoring during VMAT treatment, as an alternative to equipment-assisted methods such as active breathing control (ABC)...
March 13, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29530585/omission-of-adjuvant-radiotherapy-in-the-elderly-breast-cancer-patient-missed-opportunity
#12
Alex C Herskovic, Xian Wu, Paul J Christos, Himanshu Nagar
PURPOSE: We used the National Cancer Data Base to analyze practice patterns of adjuvant breast radiotherapy (RT) in elderly patients to see if a difference in overall survival (OS) could be detected. Additionally, we investigated factors that affected OS in these patients. PATIENTS AND METHODS: Women aged ≥ 65 years with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative pathologic T1-T2N0M0 invasive breast cancer measuring up to 3 cm who were treated with breast conservation and adjuvant endocrine therapy without adjuvant chemotherapy were identified and stratified by use of adjuvant RT...
February 20, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29502466/new-breast-cancer-radiotherapy-technology-confers-higher-complications-and-costs-before-effectiveness-proven-a-medicare-data-analysis
#13
Heather T Gold, Dawn Walter, Eleni Tousimis, Mary Katherine Hayes
A new breast cancer treatment, brachytherapy-based accelerated partial breast radiotherapy (RT), was adopted before long-term effectiveness evidence, potentially increasing morbidity and costs compared with whole breast RT. The aim of this study was to estimate complication rates and RT-specific and 1-year costs for a cohort of female Medicare beneficiaries diagnosed with breast cancer (N = 47 969). We analyzed 2005-2007 Medicare claims using multivariable logistic regression for complications and generalized linear models (log link, gamma distribution) for costs...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29483041/a-dosimetric-comparison-of-breast-radiotherapy-techniques-to-treat-locoregional-lymph-nodes-including-the-internal-mammary-chain
#14
A Ranger, A Dunlop, K Hutchinson, H Convery, M K Maclennan, H Chantler, N Twyman, C Rose, D McQuaid, R A Amos, C Griffin, N M deSouza, E Donovan, E Harris, C E Coles, A Kirby
AIMS: Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be minimised. This dosimetry study compared the ability of three-dimensional conformal radiotherapy, arc therapy and proton beam therapy (PBT) techniques with and without breath-hold to achieve target volume constraints while minimising dose to organs at risk (OARs). MATERIALS AND METHODS: In 14 patients' datasets, seven IMC radiotherapy techniques were compared: wide tangent (WT) three-dimensional conformal radiotherapy, volumetric-modulated arc therapy (VMAT) and PBT, each in voluntary deep inspiratory breath-hold (vDIBH) and free breathing (FB), and tomotherapy in FB only...
June 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29479673/the-patient-s-perspective-on-breast-radiotherapy-initial-fears-and-expectations-versus-reality
#15
Narek Shaverdian, Xiaoyan Wang, John V Hegde, Criselda Aledia, Joanne B Weidhaas, Michael L Steinberg, Susan A McCloskey
BACKGROUND: Although the efficacy and toxicity of breast radiotherapy (RT) has been studied extensively, to the authors' knowledge little is known regarding the patient's perspective on the modern breast RT experience. To better inform future patients and providers, the authors explored patient perceptions of their RT experience. METHODS: Consecutive patients who were free of disease recurrence and who had been treated between 2012 and 2016 were surveyed regarding their original fears, how short-term and long-term toxicities compared with initial expectations, and how pretreatment beliefs concerning RT compared with the actual experience...
April 15, 2018: Cancer
https://www.readbyqxmd.com/read/29463159/prophylactically-applied-hydrofilm-polyurethane-film-dressings-reduce-radiation-dermatitis-in-adjuvant-radiation-therapy-of-breast-cancer-patients
#16
Leonard Christopher Schmeel, David Koch, Sabina Stumpf, Christina Leitzen, Birgit Simon, Heinrich Schüller, Susanne Vornholt, Felix Schoroth, Thomas Müdder, Fred Röhner, Stephan Garbe, Frederic Carsten Schmeel, Hans Heinz Schild, Timo Martin Wilhelm-Buchstab
PURPOSE: Radiation-induced skin injury represents one of the most common side effects in breast cancer patients receiving adjuvant whole-breast radiotherapy. Numerous systemic and topical treatments have been studied in the prevention and management of radiation-induced skin injury without providing sustainable treatment strategies. While superficial barrier-forming skin products such as dressings are the standard of care in wound care management, their utilization as preventive treatment approach in radiotherapy has barely attracted attention...
February 20, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#17
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29436168/feasibility-study-of-individualized-optimal-positioning-selection-for-left-sided-whole-breast-radiotherapy-dibh-or-prone
#18
Hui Lin, Tianyu Liu, Chengyu Shi, Saskia Petillion, Isabelle Kindts, Caroline Weltens, Tom Depuydt, Yulin Song, Ziad Saleh, Xie George Xu, Xiaoli Tang
The deep inspiration breath hold (DIBH) and prone (P) position are two common heart-sparing techniques for external-beam radiation treatment of left-sided breast cancer patients. Clinicians select the position that is deemed to be better for tissue sparing based on their experience. This approach, however, is not always optimum and consistent. In response to this, we develop a quantitative tool that predicts the optimal positioning for the sake of organs at risk (OAR) sparing. Sixteen left-sided breast cancer patients were considered in the study, each received CT scans in the supine free breathing, supine DIBH, and prone positions...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29434659/update-on-intraoperative-radiotherapy-new-challenges-and-issues
#19
REVIEW
Emanuela Esposito, Michael Douek
Intraoperative radiotherapy (IORT) for breast cancer has challenged the standard external beam radiotherapy (EBRT) and has been shown to be non-inferior for treating early breast cancer in the past decade. Several technologies have been tested for IORT and various randomised controlled trials are still ongoing. Different methods of application of IORT have also been evaluated, from early breast cancer to tumour bed boost radiotherapy amongst high risk women. TARGIT-A and ELIOT trials have reported a low incidence of local recurrence and good survival in both arms...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29415179/incidence-of-organizing-pneumonia-after-whole-breast-radiotherapy-for-breast-cancer-and-risk-factor-analysis
#20
Hisashi Sato, Junko Ebi, Tomoaki Tamaki, Ami Yukawa, Masaru Nakajima, Tohru Ohtake, Yoshiyuki Suzuki
Radiation-induced organizing pneumonia (OP) reportedly occurs in ~2% of patients who receive whole-breast radiotherapy (WBRT). Though there are several reported risk factors, they remain unclear and controversial. We analyzed the incidence of and risk factors for OP after WBRT at our institution. We analyzed 665 breast cancer patients (with WBRT of 679 breasts) who underwent WBRT from October 2007 to September 2012 at our institution and were followed up for more than 1 year after completion of WBRT. Factors included in the analysis were age, the side affected, central lung distance (CLD), radiation dose, concurrent endocrine therapy, and chemotherapy...
February 3, 2018: Journal of Radiation Research
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