keyword
MENU ▼
Read by QxMD icon Read
search

norovirus vaccine

keyword
https://www.readbyqxmd.com/read/29718582/rota-and-norovirus-in-children-with-severe-diarrhea-in-burkina-faso-before-rotavirus-vaccine-introduction
#1
Isidore Juste O Bonkoungou, Nafissatou Ouédraogo, Laure Tamini, Rabieta Kouboura Teguera, Pouiré Yaméogo, Maxime Koiné Drabo, Isaïe Medah, Nicolas Barro, Sumit Sharma, Lennart Svensson, Johan Nordgren
Burkina Faso introduced rotavirus vaccine (RotaTeq) to the national immunization program in November 2013. This study describes the detection rates, clinical profiles and molecular epidemiology of rotavirus and norovirus infections among children <5 years hospitalized (n=154) due to acute diarrhea in Ouagadougou, Burkina Faso, from December 2012 to November 2013, just prior to start of vaccination. Overall, 44% and 23% of fecal samples were positive for rotavirus and norovirus respectively, most of them detected during the cold dry season (Dec-Mar)...
May 2, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29709903/prevention-the-spread-of-norovirus-infection-on-airborne-route-by-using-plasma-assisted-catalytic-technology-pact-device
#2
Yoshimoto Tanaka, Kan Fujino, Gerald Andrew Larkins, Atsushi Osawa, Yuji Hayashi, Satoshi Taharaguchi
Zoonosis becomes a popular word. Highly pathogenic influenza virus (HPI), Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) recently occurred at around Africa, Meddle-East and South-East Asia area, whose virus is classified as airborne. Sterilization capability was investigated by using chemical reactor of PACT device. Test on airborne infection was carried out by Feline Calicivirus Vaccine (FCV) strain F9, which is also surrogated human norovirus. It was found that PACT device could sterilize instantly FCV when passing through the plasma space of PACT device...
April 30, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29682589/parenterally-administered-norovirus-gii-4-virus-like-particle-vaccine-formulated-with-aluminum-hydroxide-or-monophosphoryl-lipid-a-adjuvants-induces-systemic-but-not-mucosal-immune-responses-in-mice
#3
Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic
Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosal immunity has a significant role in protection from infection in the intestine. Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH)3 ) or monophosphoryl lipid A (MPLA) would induce mucosal antibodies in mice...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29681427/incidence-and-characteristics-of-norovirus-associated-benign-convulsions-with-mild-gastroenteritis-in-comparison-with-rotavirus-ones
#4
Bo Ram Kim, Ga Eun Choi, Young Ok Kim, Min Ji Kim, Eun Song Song, Young Jong Woo
BACKGROUND AND PURPOSE: Rotavirus was detected in 40-50% of patients with benign convulsions with mild gastroenteritis (CwG) before the rotavirus vaccine was introduced in late 2000. However, the rate of rotavirus positivity has decreased since 2010 while the prevalence of norovirus has gradually increased. We investigated the incidence of norovirus-associated CwG during a recent 3-year period and additionally compared the characteristics of norovirus-associated CwG with those of rotavirus-associated CwG...
April 19, 2018: Brain & Development
https://www.readbyqxmd.com/read/29656244/human-organoid-cultures-transformative-new-tools-for-human-virus-studies
#5
REVIEW
Sasirekha Ramani, Sue E Crawford, Sarah E Blutt, Mary K Estes
Studies of human infectious diseases have been limited by the paucity of functional models that mimic normal human physiology and pathophysiology. Recent advances in the development of multicellular, physiologically active organotypic cultures produced from embryonic and pluripotent stem cells, as well as from stem cells isolated from biopsies and surgical specimens are allowing unprecedented new studies and discoveries about host-microbe interactions. Here, we summarize recent developments in the use of organoids for studying human viral pathogens, including intestinal infections with human rotavirus, norovirus, enteroviruses and adenoviruses (intestinal organoids and enteroids), neuronal infections with Zika virus (cerebral organoids) and respiratory infections with respiratory syncytial virus in (lung bud organoids)...
April 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29582734/knowledge-of-norovirus-and-attitudes-toward-a-potential-norovirus-vaccine-in-rural-guatemala-a-cross-sectional-exploratory-survey
#6
Daniel Olson, Steven Krager, Molly Lamb, Anne-Marie Rick, Edwin J Asturias
Given limited data on norovirus vaccine acceptance, we performed an exploratory survey in a rural Guatemalan community on knowledge, interest, and willingness to pay (WTP) for a norovirus vaccine. Cluster-randomized households with children aged 6 weeks to 17 years were enrolled into one of two norovirus surveillance studies: 1) a prospective cohort ( N = 207 households) and 2) two separate, community-based, cross-sectional surveys ( N = 420 households). After completion of the surveillance study, vaccine surveys were completed by 564 (90%) of 627 households...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29540599/development-of-a-broadly-accessible-vee-replicon-particle-vaccine-platform
#7
Sudhakar Agnihothram, Vineet D Menachery, Boyd L Yount, Lisa C Lindesmith, Trevor Scobey, Alan Whitmore, Alexandra Schäfer, Mark T Heise, Ralph S Baric
Zoonotic viruses circulate as swarms in animal reservoirs and can emerge into human populations causing epidemics that adversely affect public health. Portable, safe, and effective vaccine platforms are needed in the context of these outbreak and emergence situations. In this manuscript, we report the generation and characterization of an alphavirus replicon vaccine platform based on a non-select agent, attenuated Venezuelan equine encephalitis (VEE) virus vaccine strain 3526 (VRP 3526). Using both noroviruses and coronaviruses as model systems, we demonstrate utility of the VRP 3526 platform in generation of recombinant proteins, production of virus like particles, and in vivo efficacy as a vaccine against emergent viruses...
March 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29530860/selection-and-characterization-of-rupintrivir-resistant-norwalk-virus-replicon-cells-in-vitro
#8
Mitsutaka Kitano, Myra Hosmillo, Edward Emmott, Jia Lu, Ian Goodfellow
Human norovirus (HuNoV) is a major cause of nonbacterial gastroenteritis worldwide, yet despite its impact on society, vaccines and antivirals are currently lacking. A HuNoV replicon system has been widely applied to the evaluation of antiviral compounds and has thus accelerated the process of drug discovery against HuNoV infection. Rupintrivir, an irreversible inhibitor of the human rhinovirus 3C protease, has been reported to inhibit the replication of the Norwalk virus replicon via the inhibition of the norovirus protease...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29530841/tlr7-agonists-display-potent-antiviral-effects-against-norovirus-infection-via-innate-stimulation
#9
Daniel Enosi Tuipulotu, Natalie E Netzler, Jennifer H Lun, Jason M Mackenzie, Peter A White
Norovirus infections are a significant health and economic burden globally, accounting for hundreds of millions of cases of acute gastroenteritis every year. In the absence of an approved norovirus vaccine, there is an urgent need to develop antivirals to treat chronic infections and provide prophylactic therapy to limit viral spread during epidemics and pandemics. Toll-like receptor (TLR) agonists have been explored widely for their antiviral potential, and several are progressing through clinical trials for the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and as adjuvants for norovirus viruslike particle (VLP) vaccines...
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29529135/estimating-the-hospital-burden-of-norovirus-associated-gastroenteritis-in-england-and-its-opportunity-costs-for-non-admitted-patients
#10
Frank G Sandmann, Laura Shallcross, Natalie Adams, David J Allen, Pietro G Coen, Annette Jeanes, Zisis Kozlakidis, Lesley Larkin, Fatima Wurie, Julie V Robotham, Mark Jit, Sarah R Deeny
Background: Norovirus places a substantial burden on healthcare systems, arising from infected patients, disease outbreaks, beds kept unoccupied for infection control, and staff absences due to infection. In settings with high rates of bed occupancy, opportunity costs arise from patients who cannot be admitted due to beds being unavailable. With several treatments and vaccines against norovirus in development, quantifying the expected economic burden is timely. Methods: The number of inpatients with norovirus-associated gastroenteritis in England were modelled using infectious and non-infectious gastrointestinal Hospital Episode Statistics codes and laboratory reports of gastrointestinal pathogens collected at Public Health England...
February 26, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29446040/significance-of-continuous-rotavirus-and-norovirus-surveillance-in-indonesia
#11
REVIEW
Mohamad Saifudin Hakim, Hera Nirwati, Abu Tholib Aman, Yati Soenarto, Qiuwei Pan
BACKGROUND: Diarrhea significantly contributes to the global burden of diseases, particularly in developing countries. Rotavirus and norovirus are the most dominant viral agents responsible for diarrheal disease globally. The aim of this review was to conduct a comprehensive assessment of rotavirus and norovirus study in Indonesia. DATA SOURCES: Articles about rotavirus and norovirus surveillance in Indonesia were collected from databases, including PubMed and Google Scholar...
February 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29435493/conformational-occlusion-of-blockade-antibody-epitopes-a-novel-mechanism-of-gii-4-human-norovirus-immune-evasion
#12
Lisa C Lindesmith, Michael L Mallory, Kari Debbink, Eric F Donaldson, Paul D Brewer-Jensen, Excel W Swann, Timothy P Sheahan, Rachel L Graham, Martina Beltramello, Davide Corti, Antonio Lanzavecchia, Ralph S Baric
Extensive antigenic diversity within the GII.4 genotype of human norovirus is a major driver of pandemic emergence and a significant obstacle to development of cross-protective immunity after natural infection and vaccination. However, human and mouse monoclonal antibody studies indicate that, although rare, antibodies to conserved GII.4 blockade epitopes are generated. The mechanisms by which these epitopes evade immune surveillance are uncertain. Here, we developed a new approach for identifying conserved GII...
January 2018: MSphere
https://www.readbyqxmd.com/read/29420688/incidence-and-clinical-profile-of-norovirus-disease-in-guatemala-2008-2013
#13
Marieke Bierhoff, Wences Arvelo, Alejandra Estevez, Joe Bryan, John P McCracken, María Reneé López, Beatriz López, Umesh D Parashar, Kim A Lindblade, Aron J Hall
Background: Acute gastroenteritis (AGE) is a leading infectious cause of morbidity worldwide, particularly among children in developing countries. With the decline of rotavirus disease rates following introduction of rotavirus vaccines, the relative importance of norovirus will likely increase. The objectives of this study were to determine the incidence and clinical profile of norovirus disease in Guatemala. Methods: We analyzed data from a population-based surveillance study conducted in Guatemala from 2008-2013...
February 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29406972/norovirus-illnesses-in-children-and-adolescents
#14
REVIEW
Minesh P Shah, Aron J Hall
Norovirus is a leading cause of childhood vomiting and diarrhea in the United States and globally. Although most illnesses caused by norovirus are self-resolving, severe outcomes may occur from dehydration, including hospitalization and death. A vast majority of deaths from norovirus occur in developing countries. Immunocompromised children are at risk for more severe outcomes. Treatment of norovirus illness is focused on early correction of dehydration and maintenance of fluid status and nutrition. Hand hygiene, exclusion of ill individuals, and environmental cleaning are important for norovirus outbreak prevention and control, and vaccines to prevent norovirus illness are currently under development...
March 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29396001/molecular-surveillance-of-norovirus-2005-16-an-epidemiological-analysis-of-data-collected-from-the-noronet-network
#15
Janko van Beek, Miranda de Graaf, Haider Al-Hello, David J Allen, Katia Ambert-Balay, Nadine Botteldoorn, Mia Brytting, Javier Buesa, Maria Cabrerizo, Martin Chan, Fiona Cloak, Ilaria Di Bartolo, Susana Guix, Joanne Hewitt, Nobuhiro Iritani, Miao Jin, Reimar Johne, Ingeborg Lederer, Janet Mans, Vito Martella, Leena Maunula, Georgina McAllister, Sandra Niendorf, Hubert G Niesters, Alexander T Podkolzin, Mateja Poljsak-Prijatelj, Lasse Dam Rasmussen, Gábor Reuter, Gráinne Tuite, Annelies Kroneman, Harry Vennema, Marion P G Koopmans
BACKGROUND: The development of a vaccine for norovirus requires a detailed understanding of global genetic diversity of noroviruses. We analysed their epidemiology and diversity using surveillance data from the NoroNet network. METHODS: We included genetic sequences of norovirus specimens obtained from outbreak investigations and sporadic gastroenteritis cases between 2005 and 2016 in Europe, Asia, Oceania, and Africa. We genotyped norovirus sequences and analysed sequences that overlapped at open reading frame (ORF) 1 and ORF2...
May 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29391385/the-nice-gut-trial-protocol-a-randomised-placebo-controlled-trial-of-oral-nitazoxanide-for-the-empiric-treatment-of-acute-gastroenteritis-among-australian-aboriginal-children
#16
Claire S Waddington, Charlie McLeod, Peter Morris, Asha Bowen, Mark Naunton, Jonathan Carapetis, Keith Grimwood, Roy Robins-Browne, Carl D Kirkwood, Robert Baird, David Green, Ross Andrews, Deborah Fearon, Joshua Francis, Julie A Marsh, Thomas Snelling
INTRODUCTION: Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. Randomised trials in other populations suggest nitazoxanide accelerates recovery for children with Giardia , amoebiasis, Cryptosporidium, Rotavirus and Norovirus gastroenteritis, as well as in cases where no enteropathogens are found. METHODS AND ANALYSIS: This double blind, 1:1 randomised, placebo controlled trial is investigating the impact of oral nitazoxanide on acute gastroenteritis in hospitalised Australian Aboriginal children aged 3 months to <5 years...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29383589/detection-and-genetic-characterization-of-classic-human-astroviruses-in-brazil-2010-2012
#17
Simone Guadagnucci Morillo, Adriana Luchs, Audrey Cilli, Rita de Cássia Compagnoli Carmona, Maria do Carmo S T Timenetsky
The aims of this study were to monitor human astrovirus (HAstV) infections in patients presenting with acute gastroenteritis in Brazil and to determine the HAstV genotypes of these viruses. From May 2010 to July 2012, a total of 140 samples that were negative for both rotaviruses and noroviruses were randomly selected and tested for the presence of HAstV using an RT-PCR assay specific for the ORF2 region. Viral genotypes were identified and genetic diversity was investigated by sequencing. HAstV infection was detected in 2...
May 2018: Archives of Virology
https://www.readbyqxmd.com/read/29369754/bimodal-seasonality-and-alternating-predominance-of-norovirus-gii-4-and-non-gii-4-hong-kong-china-2014-2017-1
#18
Martin Chi-Wai Chan, Kirsty Kwok, Lin-Yao Zhang, Kirran N Mohammad, Nelson Lee, Grace C Y Lui, E Anthony S Nelson, Raymond W M Lai, Ting F Leung, Paul K S Chan
We report emerging subtropical bimodal seasonality and alternating predominance of norovirus GII.4 and non-GII.4 genotypes in Hong Kong. GII.4 predominated in summer and autumn months and affected young children, whereas emergent non-GII.4 genotypes predominated in winter months and affected all age groups. This highly dynamic epidemiology should inform vaccination strategies.
April 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29304015/development-of-a-surrogate-neutralization-assay-for-norovirus-vaccine-evaluation-at-the-cellular-level
#19
Xiaoli Wang, Shuxia Wang, Chao Zhang, Yu Zhou, Pei Xiong, Qingwei Liu, Zhong Huang
Noroviruses (NoVs) are the main pathogens responsible for sporadic and epidemic nonbacterial gastroenteritis, causing an estimated 219,000 deaths annually worldwide. There is no commercially available vaccine for NoVs, due partly to the difficulty in establishing NoV cell culture models. The histo-blood group antigen (HBGA) blocking assay is used extensively to assess the protective potential of candidate vaccine-elicited antibodies, but there is still no widely used cellular evaluation model. In this study, we have established a cell line-based NoV vaccine evaluation model through the construction of human α1,2-fucosyltransferase 2-overexpressing 293T (293T-FUT2) cell lines...
January 5, 2018: Viruses
https://www.readbyqxmd.com/read/29246474/functionality-and-avidity-of-norovirus-specific-antibodies-and-t-cells-induced-by-gii-4-virus-like-particles-alone-or-co-administered-with-different-genotypes
#20
Maria Malm, Kirsi Tamminen, Suvi Heinimäki, Timo Vesikari, Vesna Blazevic
Norovirus (NoV) is the main cause of acute gastroenteritis worldwide across all age groups. Current NoV vaccine candidates are based on non-infectious highly immunogenic virus-like particles (VLPs) produced in cell cultures in vitro. As NoVs infecting human population are highly divergent, it is proposed that the vaccine should contain at least two different NoV genotypes, potentially affecting the immunogenicity of each other. We investigated the immunogenicity of NoV GII.4 VLPs administered by intramuscular (IM) or intradermal (ID) injections to BALB/c mice either alone or co-delivered with genogroup I (GI) and other genogroup GII VLPs...
January 25, 2018: Vaccine
keyword
keyword
80193
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"