keyword
MENU ▼
Read by QxMD icon Read
search

norovirus vaccine

keyword
https://www.readbyqxmd.com/read/27914364/structure-based-exploration-and-exploitation-of-the-s4-subsite-of-norovirus-3cl-protease-in-the-design-of-potent-and-permeable-inhibitors
#1
Anushka C Galasiti Kankanamalage, Yunjeong Kim, Athri D Rathnayake, Vishnu C Damalanka, Pathum M Weerawarna, Sean T Doyle, Amer F Alsoudi, D M Padmasankha Dissanayake, Gerald H Lushington, Nurjahan Mehzabeen, Kevin P Battaile, Scott Lovell, Kyeong-Ok Chang, William C Groutas
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development of anti-norovirus agents...
November 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27853451/high-protective-efficacy-of-probiotics-and-rice-bran-against-human-norovirus-infection-and-diarrhea-in-gnotobiotic-pigs
#2
Shaohua Lei, Ashwin Ramesh, Erica Twitchell, Ke Wen, Tammy Bui, Mariah Weiss, Xingdong Yang, Jacob Kocher, Guohua Li, Ernawati Giri-Rachman, Nguyen Van Trang, Xi Jiang, Elizabeth P Ryan, Lijuan Yuan
Probiotics have been recognized as vaccine adjuvants and therapeutic agents to treat acute gastroenteritis in children. We previously showed that rice bran (RB) reduced human rotavirus diarrhea in gnotobiotic pigs. Human noroviruses (HuNoVs) are the major pathogens causing non-bacterial acute gastroenteritis worldwide. In this study, Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) were first screened for their ability to bind HuNoV P particles and virions derived from clinical samples containing HuNoV genotype GII...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27821278/targeting-pediatric-versus-elderly-populations-for-norovirus-vaccines-a-model-based-analysis-of-mass-vaccination-options
#3
Molly K Steele, Justin V Remais, Manoj Gambhir, John W Glasser, Andreas Handel, Umesh D Parashar, Benjamin A Lopman
BACKGROUND: Noroviruses are the leading cause of acute gastroenteritis and foodborne diarrheal disease in the United States. Norovirus vaccine development has progressed in recent years, but critical questions remain regarding which age groups should be vaccinated to maximize population impact. METHODS: We developed a deterministic, age-structured compartmental model of norovirus transmission and immunity in the U.S. POPULATION: The model was fit to age-specific monthly U...
October 24, 2016: Epidemics
https://www.readbyqxmd.com/read/27809881/norovirus-in-benign-convulsions-with-mild-gastroenteritis
#4
Gun-Ha Kim, Jung Hye Byeon, Deog-Yong Lee, Hyun Ju Jeong, Baik-Lin Eun
BACKGROUND: Benign convulsions with gastroenteritis (CwG) are defined as afebrile convulsions accompanying symptoms of gastroenteritis without evidence of laboratory derangement. Although the main pathogen has been known as rotavirus, since the introduction of rotavirus vaccine, associated viruses with CwG may have changed. Thus, we evaluated the viral association of CwG for patients admitting for recent 2.5 years. METHODS: All patients hospitalized for CwG between November 2012 and May 2015 were included in our study...
November 3, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27807684/inhibition-of-murine-norovirus-and-feline-calicivirus-by-edible-herbal-extracts
#5
Dong Joo Seo, Changsun Choi
Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86...
November 2, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27755184/no-when-the-immunologist-becomes-a-virologist-norovirus-an-emerging-infection-in-immune-deficiency-diseases
#6
Stella Hartono, Amrita Bhagia, Avni Y Joshi
PURPOSE OF REVIEW: Norovirus infection is an emerging chronic infection in immunocompromised hosts. The aim of this review is to discuss the pathophysiology of Norovirus infection and explore mechanistic models for chronic infection/shedder state, especially in patients with immune deficiency diseases. RECENT FINDINGS: Chronic Norovirus infection is increasingly associated with enteropathy associated with both primary and secondary immune deficiency diseases. There is an ongoing debate in the immune deficiency community whether it is truly a causative agent for the enteropathy or it is an innocent bystander...
December 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27746682/ginseng-the-natural-effectual-antiviral-protective-effects-of-korean-red-ginseng-against-viral-infection
#7
Kyungtaek Im, Jisu Kim, Hyeyoung Min
Korean Red Ginseng (KRG) is a heat-processed ginseng developed by the repeated steaming and air-drying of fresh ginseng. Compared with fresh ginseng, KRG has been shown to possess greater pharmacological activities and stability because of changes that occur in its chemical constituents during the steaming process. In addition to anticancer, anti-inflammatory, and immune-modulatory activities, KRG and its purified components have also been shown to possess protective effects against microbial infections. Here, we summarize the current knowledge on the properties of KRG and its components on infections with human pathogenic viruses such as respiratory syncytial virus, rhinovirus, influenza virus, human immunodeficiency virus, human herpes virus, hepatitis virus, norovirus, rotavirus, enterovirus, and coxsackievirus...
October 2016: Journal of Ginseng Research
https://www.readbyqxmd.com/read/27736665/norovirus-genetic-diversity-and-evolution-implications-for-antiviral-therapy
#8
Joana Rocha-Pereira, Jana Van Dycke, Johan Neyts
Human noroviruses are the leading cause of foodborne illness causing both acute and chronic gastroenteritis. In recent years, a number of vaccine candidates entered (pre-) clinical development and the first efforts to develop antiviral therapy have been made. We here discuss aspects of norovirus genetic evolution, persistence in immunocompromised patients as well as the risk and potential consequences of resistance development toward future antiviral drugs.
October 10, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27693623/characterization-of-nov-p-particle-based-chimeric-protein-vaccines-developed-from-two-different-expression-systems
#9
Lu Fu, Hao Jin, Yongjiao Yu, Bin Yu, Haihong Zhang, Jiaxin Wu, Yuhe Yin, Xianghui Yu, Hui Wu, Wei Kong
The Norovirus (NoV) P domain, with three surface loops for foreign antigen insertion, has been demonstrated as an excellent platform for antigen presentation and novel vaccine development. The P domain alone can self-assemble into a P dimer, 12-mer small particle or 24-mer P particle, and vaccines based on those particles may elicit different levels of immunogenicity. Currently, P particles are generally produced in soluble expression systems in Escherichia coli, mainly in the 24-mer form. However, the low yield of the soluble protein has hindered further clinical applications of P particle-based protein vaccines...
September 28, 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/27689099/rotavirus-recombinant-vp6-nanotubes-act-as-an-immunomodulator-and-delivery-vehicle-for-norovirus-virus-like-particles
#10
Maria Malm, Kirsi Tamminen, Suvi Lappalainen, Timo Vesikari, Vesna Blazevic
We have recently shown that tubular form of rotavirus (RV) recombinant VP6 protein has an in vivo adjuvant effect on the immunogenicity of norovirus (NoV) virus-like particle (VLP) vaccine candidate. In here, we investigated in vitro effect of VP6 on antigen presenting cell (APC) activation and maturation and whether VP6 facilitates NoV VLP uptake by these APCs. Mouse macrophage cell line RAW 264.7 and dendritic cell line JAWSII were used as model APCs. Internalization of VP6, cell surface expression of CD40, CD80, CD86, and major histocompatibility class II molecules, and cytokine and chemokine production were analyzed...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27664943/detection-of-poliovirus-infection-in-children-with-acute-gastroenteritis-in-chiang-mai-thailand
#11
Kattareeya Kumthip, Pattara Khamrin, Niwat Maneekarn
Poliovirus (PV) is typically transmitted by the fecal-oral route, which means that the risk of infection and virus distribution could be achieved by exposure to the virus contaminated in food and water. The aim of this study was to determine the occurrence of PV strains by detecting the virus in pediatric patients who admitted to the hospitals with diarrhea in Chiang Mai, Thailand during 2010-2015. By applying a reverse transcription-polymerase chain reaction and nucleotide sequencing analysis of 1,300 stool specimens collected from pediatric patients, PVs were detected at 0...
September 24, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27615516/viral-gastrointestinal-infections-and-norovirus-genotypes-in-a-paediatric-uk-hospital-2014-2015
#12
Julianne R Brown, Divya Shah, Judy Breuer
BACKGROUND: Diarrhoea in children is a common disease; understanding the incidence of causative viruses can aid infection control and vaccine development. OBJECTIVES: Describe the incidence and characteristics of gastroenteric viruses including norovirus genotypes in a paediatric hospital cohort. STUDY DESIGN: Norovirus, adenovirus, sapovirus, astrovirus, rotavirus qPCR and norovirus genotyping results for all stool specimens (n=4786; 1393 patients) at a UK paediatric tertiary referral hospital June 2014-July 2015...
August 30, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27527773/infectivity-of-a-recombinant-murine-norovirus-recmnv-in-balb-cbyj-mice
#13
Elisabeth Mathijs, Edmilson F de Oliveira-Filho, Fabiana Dal Pozzo, Axel Mauroy, Damien Thiry, François Massart, Claude Saegerman, Etienne Thiry
The infectivity of a recombinant murine norovirus (RecMNV) strain, previously isolated following in vitro coinfections, was evaluated in vivo in comparison with its parental strains (MNV-1-CW1 and WU20) in Balb/cByJ mice via measurement of weight loss and estimation of viral loads in faeces, tissues and organs 48 and 72h post-infection. The presence of infectious virus in all analysed tissues and organs suggests that, similarly to its parental viruses, RecMNV can disseminate beyond organs associated with the digestive tract...
August 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27503019/viral-and-bacterial-etiology-of-acute-diarrhea-among-children-under-5-years-of-age-in-wuhan-china
#14
Xu-Hui Zhu, Lei Tian, Zhong-Ju Cheng, Wei-Yong Liu, Song Li, Wei-Ting Yu, Wen-Qian Zhang, Xu Xiang, Zi-Yong Sun
BACKGROUND: Acute diarrhea remains the serious problem in developing countries, especially among children under 5 years of age. Currently, only two or three common diarrhea pathogens were screened at most hospitals in China. The aim of this study was to provide a wide variety of diarrhea pathogens and their antimicrobial resistance patterns in children under 5 years of age. METHODS: Totally 381 stool samples collected from Tongji Hospital between July 1, 2014 and June 30, 2015 were tested by culture and/or polymerase chain reaction for eight kinds of bacteria and five kinds of viruses...
August 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27495982/correction-for-hesse-et-al-serological-responses-to-a-norovirus-nonstructural-fusion-protein-after-vaccination-and-infection
#15
Shayla Hesse, Frederick H Neill, Mary K Estes, Sreejesh Shanker, B V Venkataram Prasad, Jennifer Ferreira, Robert L Atmar
No abstract text is available yet for this article.
August 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27476607/characterization-of-novel-intragenotype-recombination-events-among-norovirus-pandemic-gii-4-variants
#16
Jones Anderson Monteiro Siqueira, Renato da Silva Bandeira, Maria Cleonice Aguiar Justino, Alexandre da Costa Linhares, Yvone Benchimol Gabbay
Recently, there has been an increase in the number of children hospitalized due to norovirus infection in Brazil. This is due both to the occurrence of more severe norovirus-related gastroenteritis cases after the introduction of the rotavirus vaccine and an increase in the tools for the detection of the disease. This pathogen is transmitted by the fecal-oral route, and the illness is characterized by diarrhea, vomiting, nausea and abdominal cramps. The genome of the virus is organized into three open reading frames showing strong mutation rates...
October 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27455440/decrease-of-rotavirus-gastroenteritis-to-a-low-level-without-resurgence-for-5-years-after-universal-rotateq%C3%A2-vaccination-in-finland
#17
Maria Hemming-Harlo, Jukka Markkula, Leena Huhti, Marjo Salminen, Timo Vesikari
BACKGROUND: Universal rotavirus (RV) vaccination with RotaTeq® was introduced into National Immunization Programme (NIP) of Finland in September 2009. We have previously reported reduction of RV gastroenteritis (GE) cases in the first two years after RV vaccination in NIP in Finland. MATERIAL AND METHODS: In Tampere University Hospital, a 2-year survey of acute gastroenteritis (AGE) in children was conducted before NIP in the years 2006-2008. This was followed by a similar prospective survey in years 2009-2011 and now extended to years 2012-2014...
July 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27365054/comparison-of-norovirus-genogroup-i-ii-and-iv-seroprevalence-among-children-in-the-netherlands-1963-1983-and-2006
#18
Janko van Beek, Miranda de Graaf, Ming Xia, Xi Jiang, Jan Vinjé, Mathias Beersma, Erwin de Bruin, David van de Vijver, Melle Holwerda, Marlies van Houten, Annemarie M Buisman, Rob van Binnendijk, Albert D M E Osterhaus, Fiona van der Klis, Harry Vennema, Marion P G Koopmans
Noroviruses are a major cause of acute gastroenteritis worldwide and are a genetically diverse group of viruses. Since 2002, an increasing number of norovirus outbreaks have been reported globally, but it is not clear whether this increase has been caused by a higher awareness or reflects the emergence of new genogroup II genotype 4 (GII.4) variants. The hypothesis that norovirus prevalence has increased post-2002 and is related to the emergence of GII.4 is tested in this study. Sera collected from children aged <5 years of three Dutch cross-sectional population based cohorts in 1963, 1983 and 2006/2007 (n=143, n=130 and n=376, respectively) were tested for specific serum IgG by protein array using antigens to GII...
September 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27355511/frequent-use-of-the-iga-isotype-in-human-b-cells-encoding-potent-norovirus-specific-monoclonal-antibodies-that-block-hbga-binding
#19
Gopal Sapparapu, Rita Czakó, Gabriela Alvarado, Sreejesh Shanker, B V Venkataram Prasad, Robert L Atmar, Mary K Estes, James E Crowe
Noroviruses (NoV) are the most common cause of non-bacterial acute gastroenteritis and cause local outbreaks of illness, especially in confined situations. Despite being identified four decades ago, the correlates of protection against norovirus gastroenteritis are still being elucidated. Recent studies have shown an association of protection with NoV-specific serum histo-blood group antigen-blocking antibody and with serum IgA in patients vaccinated with NoV VLPs. Here, we describe the isolation and characterization of human monoclonal IgG and IgA antibodies against a GI...
June 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27354368/rapid-responses-to-2-virus-like-particle-norovirus-vaccine-candidate-formulations-in-healthy-adults-a-randomized-controlled-trial
#20
Robert L Atmar, Frank Baehner, Jakob P Cramer, Eric Song, Astrid Borkowski, Paul M Mendelman
BACKGROUND: Noroviruses pose a significant public health risk, particularly in very young individuals, older adults, and individuals with underlying conditions. We assessed 2 bivalent norovirus virus-like particle (VLP) vaccine candidate formulations in healthy adults aged 18-49 years. METHODS: Enrolled subjects (n = 454) randomly assigned among 3 groups received intramuscular placebo (saline) or vaccines containing either 15 µg or 50 µg of GI.1 VLP and 50 µg GII...
September 15, 2016: Journal of Infectious Diseases
keyword
keyword
80193
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"