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https://www.readbyqxmd.com/read/29771697/influenza-vaccine-strategies-for-solid-organ-transplant-recipients
#1
Cédric Hirzel, Deepali Kumar
PURPOSE OF REVIEW: The aim of this study was to highlight recent evidence on important aspects of influenza vaccination in solid organ transplant recipients. RECENT FINDINGS: Influenza vaccine is the most evaluated vaccine in transplant recipients. The immunogenicity of the vaccine is suboptimal after transplantation. Newer formulations such as inactivated unadjuvanted high-dose influenza vaccine and the administration of a booster dose within the same season have shown to increase response rates...
May 15, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29769448/tlr-adjuvanted-nanoparticle-vaccines-differentially-influence-the-quality-and-longevity-of-responses-to-malaria-antigen-pfs25
#2
Elizabeth A Thompson, Sebastian Ols, Kazutoyo Miura, Kelly Rausch, David L Narum, Mats Spångberg, Michal Juraska, Ulrike Wille-Reece, Amy Weiner, Randall F Howard, Carole A Long, Patrick E Duffy, Lloyd Johnston, Conlin P O'Neil, Karin Loré
Transmission-blocking vaccines (TBVs) are considered an integral element of malaria eradication efforts. Despite promising evaluations of Plasmodium falciparum Pfs25-based TBVs in mice, clinical trials have failed to induce robust and long-lived Ab titers, in part due to the poorly immunogenic nature of Pfs25. Using nonhuman primates, we demonstrate that multiple aspects of Pfs25 immunity were enhanced by antigen encapsulation in poly(lactic-co-glycolic acid)-based [(PLGA)-based] synthetic vaccine particles (SVP[Pfs25]) and potent TLR-based adjuvants...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29769270/effective-combination-adjuvants-engage-both-tlr-and-inflammasome-pathways-to-promote-potent-adaptive-immune-responses
#3
Emilie Seydoux, Hong Liang, Natasha Dubois Cauwelaert, Michelle Archer, Nicholas D Rintala, Ryan Kramer, Darrick Carter, Christopher B Fox, Mark T Orr
The involvement of innate receptors that recognize pathogen- and danger-associated molecular patterns is critical to programming an effective adaptive immune response to vaccination. The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) synergizes with the squalene oil-in-water emulsion (SE) formulation to induce strong adaptive responses. Although TLR4 signaling through MyD88 and TIR domain-containing adapter inducing IFN-β are essential for GLA-SE activity, the mechanisms underlying the synergistic activity of GLA and SE are not fully understood...
May 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29769118/protection-against-neonatal-enteric-colibacillosis-employing-e-coli-derived-outer-membrane-vesicles-in-formulation-and-without-vitamin-d3
#4
Babak Beikzadeh, Gholamreza Nikbakht Brujeni
OBJECTIVE: Enterotoxigenic Escherichia Coli (ETEC) is the cause of diarrhea and even death in humans and offspring of animals. Outer membrane vesicles (OMVs) of the ETEC was prepared and its potential as a vaccine candidate against enteric colibacillosis in neonatal mice was evaluated. Dam mice intradermally injected with ETEC-derived OMVs and OMVs plus an active form of vitamin D3 (avD3). Mucosal and systemic immune responses in mice and passive immunity protection against ETEC lethality in their offspring was investigated...
May 16, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29767789/effects-of-tannic-acid-extract-on-performance-and-intestinal-health-of-broiler-chickens-following-coccidiosis-vaccination-and-or-a-mixed-species-eimeria-challenge
#5
R M Tonda, J K Rubach, B S Lumpkins, G F Mathis, M J Poss
Two experiments were conducted to investigate the effects of tannic acid extract (TAE) formulations on the performance and intestinal health of male Cobb × Cobb 500 broilers exposed to coccidiosis. In the first experiment, 320 broiler chicks were randomly assigned to 5 treatments with 8 replicates. Treatments included non-medicated, uninfected (NC); non-medicated, infected (PC); salinomycin (SAL, 66 mg/kg); tannic acid (TA, 0.5 g/kg) and TAE (TAE, 0.5 g/kg). On d 14, all groups (except NC) were orally inoculated with Eimeria acervulina, E...
May 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29766005/the-enhancement-of-the-pasteurella-s-bacterin-by-propolis-extracts
#6
Tarek Adnan Ahmad, Samar Saeed Rammah, Salah Ahmed Sheweita, Medhat Haroun, Laila Hamdy El-Sayed
Background: Pasteurella multocida continues to pose a danger to prone farm and wild animals all over the world. Chemotherapeutic treatments are progressively losing their effectiveness, last for long time, and cost a lot of money, as well as being toxic to human consumers. Therefore, clearing the way for immunization as a big-wheel alternative against the economic grain. Yet, the vaccines available in the market do not confer the necessary protection against the pathogen. The integration of the well adjuvanted killed vaccine with the attenuated vaccines proved to offer an effective protection to the host animals...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765911/immunization-with-skp-delivered-on-outer-membrane-vesicles-protects-mice-against-enterotoxigenic-escherichia-coli-challenge
#7
Michael P Hays, Diane Houben, Yang Yang, Joen Luirink, Philip R Hardwidge
Outer membrane vesicles (OMVs) are promising vaccine components because they combine antigen and adjuvant in a single formulation. Detoxified Salmonella enterica strains that express penta-acylated lipid A retain OMV immunogenicity but with reduced reactogenicity. We have previously shown that a recombinant form of the enterotoxigenic Escherichia coli (ETEC) 17 kilodalton protein (Skp) protects mice in a pulmonary challenge model, when fused to the glutathione-S-transferase (GST) epitope and combined with cholera toxin...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29761648/poly-%C3%AE-amino-ester-co-poly-caprolactone-terpolymers-as-nonviral-vectors-for-mrna-delivery-in-vitro-and-in-vivo
#8
Umberto Capasso Palmiero, James C Kaczmarek, Owen S Fenton, Daniel G Anderson
The production of new proteins with messenger RNA (mRNA) has gained a broad interest due to its potential for addressing a wide range of diseases. Here, the design and characterization of novel ionizable poly(β-amino ester)-co-poly(caprolactone) terpolymers, synthesized via the combination of the ring opening polymerization and the Michael step-growth polymerization, are reported. The versatility of this method is demonstrated by varying the number of caprolactone units attached to each poly(β-amino ester) (PBAE) terpolymer...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29760705/induction-of-cytotoxic-t-lymphocyte-responses-upon-subcutaneous-administration-of-a-subunit-vaccine-adjuvanted-with-an-emulsion-containing-the-toll-like-receptor-3-ligand-poly-i-c
#9
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Malene Aaby Neustrup, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Camilla Foged, Dennis Christensen
There is an unmet medical need for new subunit vaccines that induce cytotoxic T-lymphocyte (CTL) responses to prevent infection with a number of pathogens. However, stimulation of CTL responses via clinically acceptable subcutaneous (s.c.) and intramuscular (i.m.) injection is challenging. Recently, we designed a liposomal adjuvant [cationic adjuvant formulation (CAF)09] composed of the cationic lipid dimethyldioctadecylammonium (DDA) bromide, a synthetic monomycoloyl glycerol analog and polyinosinic:polycytidylic acid, which induce strong CTL responses to peptide and protein antigens after intraperitoneal administration...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755461/efficient-uptake-of-recombinant-lipidated-survivin-by-antigen-presenting-cells-initiates-antigen-cross-presentation-and-antitumor-immunity
#10
Chen-Yi Chiang, Yi-Jyun Chen, Chiao-Chieh Wu, Shih-Jen Liu, Chih-Hsiang Leng, Hsin-Wei Chen
Survivin is overexpressed in various types of human cancer, but rarely expressed in terminally differentiated adult tissues. Thus, survivin is a potential target antigen for a cancer vaccine. However, self-tumor-associated antigens are not highly immunogenic. Bacteria-derived lipoproteins can activate antigen-presenting cells through their toll-like receptors to enhance immune responses. In this context, lipidated survivin is an attractive candidate for cancer immunotherapy. In the present study, recombinant lipidated human survivin (LSur) was prepared from an Escherichia coli -based system...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755431/outer-membrane-vesicles-current-status-and-future-direction-of-these-novel-vaccine-adjuvants
#11
REVIEW
Kuang Tan, Ruizhen Li, Xiaotian Huang, Qiong Liu
Adjuvants have been of great interest to vaccine formulation as immune-stimulators. Prior to the recent research in the field of immune stimulation, conventional adjuvants utilized for aluminum-based vaccinations dominated the adjuvant market. However, these conventional adjuvants have demonstrated obvious defects, including poor protective efficiency and potential side effects, which hindered their widespread circulation. Outer membrane vesicles (OMVs) naturally exist in gram-negative bacteria and are capable of engaging innate and adaptive immunity and possess intrinsic adjuvant capacity...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29743502/the-amino-acid-selected-for-generating-mutant-tbpb-antigens-defective-in-binding-transferrin-can-compromise-the-in-vivo-protective-capacity
#12
João Antônio Guizzo, Somshukla Chaudhuri, Simone Ramos Prigol, Rong-Hua Yu, Cláudia Cerutti Dazzi, Natalia Balbinott, Gabriela Paraboni Frandoloso, Luiz Carlos Kreutz, Rafael Frandoloso, Anthony Bernard Schryvers
Haemophilus parasuis is the causative agent of the Glässer's disease (GD), one of the most important bacterial diseases that affect young pigs worldwide. GD prevention based on vaccination is a major concern due to the limited cross-protection conferred by the inactivated whole cell vaccines used currently. In this study, vaccines based on two mutant recombinant proteins derived from transferrin binding protein B of H. parasuis (Y167A-TbpB and W176A-TbpB) were formulated and evaluated in terms of protection against lethal challenge using a serovar 7 (SV7) H...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742893/synthesis-liposomal-formulation-and-immunological-evaluation-of-a-minimalistic-carbohydrate-%C3%AE-galcer-vaccine-candidate
#13
Felix Broecker, Sebastian Götze, Jonathan Hudon, Dominea C K Rathwell, Claney L Pereira, Pierre Stallforth, Anish Chakkumkal, Peter H Seeberger
Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic vaccines against infectious diseases as well as cancer. Here, we present a two-component platform based on the facile conjugation of carbohydrate antigens to α-galactosylceramide (α-GalCer) to yield fully synthetic vaccine candidates. Formulation of a cancer-associated Tn antigen glycolipid model vaccine candidate into liposomes of different sizes and subsequent immunization of mice generated specific, high-affinity antibodies against the carbohydrate antigen with characteristics of T cell-dependent immunity...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29742226/influenza-a-non-h1n1-associated-with-acute-respiratory-failure-and-acute-renal-failure-in-a-previously-vaccinated-cystic-fibrosis-patient
#14
Louise Piva Penteado, Cecília Susin Osório, Antônio Balbinotto, Paulo de Tarso Roth Dalcin
In the 2014 - 2015 season, most influenza infections were due to A (H3N2) viruses. More than two-thirds of circulating A (H3N2) viruses are antigenically and genetically different (drifted) from the A (H3N2) vaccine component of 2014 - 2015 northern and southern Hemisphere seasonal influenza vaccines. The purpose of this paper is to report a case of seasonal influenza A non-H1N1 infection that occurred in June 2015 in an adult cystic fibrosis patient with severe lung disease previously vaccinated with the anti-flu trivalent vaccine...
March 2018: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29739720/heterologous-prime-boost-vaccination-with-adenoviral-vector-and-protein-nanoparticles-induces-both-th1-and-th2-responses-against-middle-east-respiratory-syndrome-coronavirus
#15
Seo-Yeon Jung, Kyung Won Kang, Eun-Young Lee, Dong-Won Seo, Hong-Lim Kim, Hak Kim, TaeWoo Kwon, Hye-Lim Park, Hun Kim, Sang-Myeong Lee, Jae-Hwan Nam
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29735325/alternate-vaccine-strain-selection-in-the-wake-of-emerging-foot-and-mouth-disease-virus-serotype-a-antigenic-variants-in-india
#16
Jajati Keshari Mohapatra, Biswajit Das, Manoranjan Rout, B P Sreenivasa, Saravanan Subramaniam, Aniket Sanyal, Bramhadev Pattnaik
'National foot-and-mouth disease (FMD) control programme' is being implemented in India and therefore predicting vaccine match is a key surveillance task. Recently, a considerable proportion of field viruses (75.6%) showed antigenic drift from the existing serotype A vaccine strain A IND 40/2000 necessitating search for an alternate strain. Here, antigenic relationship ('r1 ' value) of 87 field viruses with each of the 8 candidate strains was estimated by virus neutralization test. A IND 27/2011 strain emerged to be the one with the widest spectrum of antigenic coverage showing 'r1 ' value of more than 0...
May 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29729407/from-allergen-to-oral-vaccine-carrier-a-new-face-of-ragweed-pollen
#17
Md Jasim Uddin, Harvinder Singh Gill
Oral delivery of vaccines is highly desirable, yet it has met with limited success. Previously we developed allergen-free pollen grains as a novel approach for oral vaccination. We showed that spores of Lycopodium clavatum can be used for oral vaccination. However, it is unknown if pollens of other species can be similarly used as an oral vaccine carrier. Therefore, in this study, we evaluated common ragweed (RW) pollen (Ambrosia elatior) for its oral vaccination potential. Allergen-free RW pollens were prepared from natural pollens through chemical treatment...
May 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29728823/comparison-of-protection-and-viral-shedding-following-vaccination-with-newcastle-disease-virus-strains-of-different-genotypes-used-in-vaccine-formulation
#18
Abdul Wajid, Asma Basharat, Tasra Bibi, Shafqat Fatima Rehmani
Newcastle disease (ND) is a devastating disease and cause high t mortality and morbidity in poultry and nonpoultry avian species worldwide. An intensive vaccination program against ND is a routine practice in Pakistan like other developing countries, but still frequent outbreaks have been recorded in the field. In this study, vaccines prepared from ND viruses corresponding to four different genotypes were compared, to determine if the phylogenetic distance between vaccine and challenge strain influences the protection induced the amount of challenge virus shed...
May 4, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29728336/evaluation-of-the-protective-efficacy-of-ornithodoros-moubata-midgut-membrane-antigens-selected-using-omics-and-in-silico-prediction-algorithms
#19
Prosper Obolo-Mvoulouga, Ana Oleaga, Raúl Manzano-Román, Ricardo Pérez-Sánchez
The African argasid tick Ornithodoros moubata transmits two important pathogens, the African swine fever virus and the spirochete Borrelia duttoni, the cause of human relapsing fever. To date, only conventional control measures such as widespread application of acaricides, strict control measures, and animal movement restrictions have been implemented to confine these diseases. Vaccines against tick infestations have the potential to be among the most efficacious interventions for the management of these diseases...
April 30, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29725603/stimulation-of-dectin-1-and-dectin-2-during-parenteral-immunization-but-not-mincle-induces-secretory-iga-in-intestinal-mucosa
#20
Alina S Dzharullaeva, Amir I Tukhvatulin, Alina S Erokhova, Alina S Bandelyuk, Nikita B Polyakov, Andrey I Solovyev, Natalia A Nikitenko, Dmitry V Shcheblyakov, Boris S Naroditsky, Denis Y Logunov, Alexander L Gintsburg
Induction of a robust and long-lived mucosal immune response during vaccination is critical to achieve protection against numerous pathogens. However, traditional injected vaccines are generally poor inducers of mucosal immunity. One of the effective strategies to improve vaccine efficacy is incorporation of adjuvant molecules that enhance and polarize adaptive immune reactions. Effects of Syk-coupled lectin receptor agonists as adjuvants to induce mucosal immune reactions during parenteral immunization are not fully studied...
2018: Journal of Immunology Research
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