Dan Chen, Xindi Zhou, Chun Gan, Qing Yang, Wanbing Chen, Xiaoqian Feng, Tao Zhang, Li Zhang, Lujun Dai, Yaxi Chen, Haiping Yang, Mo Wang, Wei Jiang, Qiu Li
BACKGROUND: Disruptions in gene expression associated with the glomerular basement membrane (GBM) could precipitate glomerular dysfunction. Nevertheless, a comprehensive understanding of the characterization of GBM components within pediatric glomerular diseases and their potential association with glomerular function necessitates further systematic investigation. METHODS: We conducted a systematic analysis focusing on the pathological transformations and molecular attributes of key constituents within the GBM, specifically Collagen IV α3α4α5, Laminin α5β2γ1, and Integrin α3β1, across prevalent pediatric glomerular diseases...
March 2024: Clinical Kidney Journal