Pedro M Rodrigues, Marta B Afonso, André L Simão, Tawhidul Islam, Maria M Gaspar, Colm J O'Rourke, Monika Lewinska, Jesper B Andersen, Enara Arretxe, Cristina Alonso, Álvaro Santos-Laso, Laura Izquierdo-Sanchez, Raúl Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J Pareja, Carina Prip-Buus, Jesus M Banales, Cecília M P Rodrigues, Rui E Castro
BACKGROUND AND AIMS: The mechanisms governing the progression of non-alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain elusive. Here, we evaluated the role of hsa-miRNA-21-5p in NASH-related hepatocarcinogenesis. METHODS: Hepatic hsa-miR-21-5p expression was evaluated in two cohorts of patients with biopsy-proven NAFLD (n = 199) or HCC (n = 366 HCC and n = 11 NAFLD-HCC)...
August 3, 2023: Liver International: Official Journal of the International Association for the Study of the Liver