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miRNA,Hepatic fibrosis

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https://www.readbyqxmd.com/read/29892294/the-interleukin-20-cytokine-family-in-liver-disease
#1
REVIEW
Esther Caparrós, Rubén Francés
The three main causes of inflammation and chronic injury in the liver are viral hepatitis, alcohol consumption, and non-alcoholic steatohepatitis, all of which can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, which in turn may prompt the need for liver transplant. The interleukin (IL)-20 is a subfamily part of the IL-10 family of cytokines that helps the liver respond to damage and disease, they participate in the control of tissue homeostasis, and in the immunological responses developed in this organ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29881991/plasma-mirna-122-5p-and-mirna-151a-3p-identified-as-potential-biomarkers-for-liver-injury-among-chb-patients-with-pnalt
#2
Jin-Lin Cheng, Hong Zhao, Shi-Gui Yang, Er-Mei Chen, Wen-Qian Chen, Lan-Juan Li
BACKGROUND: Plasma microRNA (miRNA) levels may be altered during pathological processes; therefore, they may potentially serve as biomarkers for the diagnosis and prognosis of human diseases. This study aimed to explore whether plasma miRNAs may serve as new biomarkers for liver injury among chronic hepatitis B (CHB) patients with normal or nearly normal alanine aminotransferase (ALT) levels. METHODS: Plasma miRNAs from each of three independent groups (no prominent liver injury and persistently normal ALT levels, NPNALT; significant liver injury with persistently normal ALT levels, SPNALT; and healthy) were profiled by miRNA microarray analysis...
June 7, 2018: Hepatology International
https://www.readbyqxmd.com/read/29881235/hepatitis-b-virus-pathogenesis-fresh-insights-into-hepatitis-b-virus-rna
#3
REVIEW
Kazuma Sekiba, Motoyuki Otsuka, Motoko Ohno, Mari Yamagami, Takahiro Kishikawa, Tatsunori Suzuki, Rei Ishibashi, Takahiro Seimiya, Eri Tanaka, Kazuhiko Koike
Hepatitis B virus (HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host miRNAs and may deregulate miRNA functions, possibly leading to pathological consequences...
June 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29807039/large-scale-screening-of-circulating-micrornas-in-individuals-with-hiv-1-mono-infections-reveals-specific-liver-damage-signatures
#4
Sandra Franco, Daniela Buccione, Raquel Pluvinet, Beatriz Mothe, Lidia Ruiz, Maria Nevot, Ana Jordan-Paiz, Laia Ramos, Susanna Aussó, Rosa M Morillas, Lauro Sumoy, Miguel Angel Martinez, Cristina Tural
Human immunodeficiency virus type 1 (HIV-1)-induced inflammation and/or long-term antiretroviral drug toxicity may contribute to the evolution of liver disease. We investigated circulating plasma microRNAs (miRNAs) as potential biomarkers of liver injury in patients mono-infected with HIV-1. We performed large-scale deep sequencing analyses of small RNA level on plasma samples from patients with HIV-1 mono-infection that had elevated or normal levels of alanine aminotransferase (ALT) or focal nodular hyperplasia (FNH)...
May 25, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29740327/extracellular-vesicles-as-carriers-of-non-coding-rnas-in-liver-diseases
#5
REVIEW
Junfa Yang, Changyao Li, Lei Zhang, Xiao Wang
Extracellular vesicles (EVs) are small membranous vesicles secreted from normal, diseased, and transformed cells in vitro and in vivo . EVs have been found to play a critical role in cell-to-cell communication by transferring non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long ncRNAs (lncRNAs) and so on. Emerging evidence shows that transferring biological information through EVs to neighboring cells in intercellular communication not only keep physiological functions, but also participate in the pathogenesis of liver diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29627726/generation-of-wae001-a-15-a-human-embryonic-stem-cell-line-with-mir-122-doxycycline-inducible-expression
#6
Yanli Liu, Feima Wu, Dong Liu, Ruzhi Wei, Nasir Abbas, Jianhong Xia, Dongwei Li, Haiyun Wang, Yuanqi Zhuang, Dongsheng Guo, Yan Chen, Yuhang Wu, Xinrong Ke, Jiawang Tao, Fan Yang, Keyu Lai, Xiaodong Shu, Yin-Xiong Li
MiR-122 is the most abundant miRNA in the human liver accounting for 52% of the entire hepatic miRNome. Previous studies have demonstrated that miR-122 is a valuable therapeutic target for liver diseases, including viral hepatitis, fibrosis, steatosis, and hepatocarcinoma. Here, we constructed a miR-122 doxycycline-inducible expression human embryonic stem cell line WAe001-A-15 using the piggyBac transposon system. The cell line retained its pluripotency, in vitro differentiation potential, normal morphology, and karyotype...
March 23, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29587268/microrna-30a-suppresses-the-activation-of-hepatic-stellate-cells-by-inhibiting-epithelial-to-mesenchymal-transition
#7
Jianjian Zheng, Wei Wang, Fujun Yu, Peihong Dong, Bicheng Chen, Meng-Tao Zhou
BACKGROUND/AIMS: The activation of hepatic stellate cells (HSCs) is considered as a pivotal event in liver fibrosis and epithelial-mesenchymal transition (EMT) process has been reported to be involved in HSC activation. It is known that microRNAs (miRNAs) play a pro-fibrotic or anti-fibrotic role in HSC activation. Recently, emerging studies show that miR-30a is down-regulated in human cancers and over-expression of miR-30a inhibits tumor growth and invasion via suppressing EMT process...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29564929/hepatotoxicity-after-paracetamol-overdose-in-a-patient-with-cystic-fibrosis-despite-early-acetylcysteine-and-utility-of-microrna-to-predict-hepatotoxicity
#8
Anselm Wong, Benjamin Cheung, Charlotte Nejad, Michael Gantier, Andis Graudins
CASE DETAILS: A 19-year-old girl presented to the emergency department following overdose of 10 g of paracetamol on a background history of cystic fibrosis. Paracetamol concentration was below the nomogram line, but was treated with acetylcysteine seven hours post-overdose given her symptomatology. Nineteen hours following her overdose she developed hepatotoxicity, despite early initiation of acetylcysteine. She was discharged well six days post-ingestion. On presentation, delta miRNA-122-miR483 was 20 times that of control patients, however, alanine aminotransferase was normal...
March 22, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29554131/down-regulation-of-microrna-203-3p-initiates-type-2-pathology-during-schistosome-infection-via-elevation-of-interleukin-33
#9
Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan
The type 2 immune response is the central mechanism of disease progression in schistosomiasis, but the signals that induce it after infection remain elusive. Aberrant microRNA (miRNA) expression is a hallmark of human diseases including schistosomiasis, and targeting the deregulated miRNA can mitigate disease outcomes. Here, we demonstrate that efficient and sustained elevation of miR-203-3p in liver tissues, using the highly hepatotropic recombinant adeno-associated virus serotype 8 (rAAV8), protects mice against lethal schistosome infection by alleviating hepatic fibrosis...
March 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29524604/altered-global-microrna-expression-in-hepatic-stellate-cells-lx-2-by-angiotensin-1-7-and-mirna-1914-5p-identification-as-regulator-of-pro-fibrogenic-elements-and-lipid-metabolism
#10
Brenda de Oliveira da Silva, Luciane Carla Alberici, Letícia Ferreira Ramos, Caio Mateus Silva, Marina Bonfogo da Silveira, Carlos R P Dechant, Scott L Friedman, Kumiko Koibuchi Sakane, Letícia Rocha Gonçalves, Karen C M Moraes
The development of new therapeutic strategies to control or reverse hepatic fibrosis requires thorough knowledge about its molecular and cellular basis. It is known that the heptapeptide angiotensin-(1-7) [ang-(1-7)] can reduce hepatic fibrosis and steatosis in vivo; therefore, it is important to uncover the mechanisms regulating its activity and cellular model of investigation. Ang-(1-7) is a peptide of the renin-angiotensin system (RAS), and here we investigated its modulatory effect on the expression pattern of microRNAs (miRNAs) in hepatic stellate cells (HSCs) LX-2, which transdifferentiate into fibrogenic and proliferative cells...
May 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29469324/-changes-of-liver-fibrosis-related-mirnas-induced-by-soluble-egg-antigen-of-schistosoma-japonicum
#11
Wang Huan, Lu Ya-Jing, Gao Yan-Ru, Wang Shu-Hong, Zhou Rui, Dong Hui-Fen
OBJECTIVE: To investigate the expression of miRNA associated with hepatic fibrosis induced by Schistosoma japonicum soluble egg antigen stimulation in mouse hepatocytes (AML12), so as to lay the foundation for clarifying the mechanism of schistosome infection leading to hepatic fibrosis. METHODS: The expressions of miR-122, miR-182, miR-23b, miR27b and KSRP in AML12 cells treated with SEA were measured by q-PCR. KSRP protein in cell lyses was measured by Western blotting...
March 8, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29426919/dietary-supplementation-with-hybrid-palm-oil-alters-liver-function-in-the-common-marmoset
#12
Flavia Spreafico, Rafael Carvalho Sales, Judit Gil-Zamorano, Priscylla da Costa Medeiros, Maria-Jesús Latasa, Monique Ribeiro Lima, Sergio Augusto Lopes de Souza, Roberto Martin-Hernández, Diego Gómez-Coronado, Eduardo Iglesias-Gutierrez, Diana C Mantilla-Escalante, Maria das Graças Tavares do Carmo, Alberto Dávalos
Hybrid palm oil, which contains higher levels of oleic acid and lower saturated fatty acids in comparison with African palm oil, has been proposed to be somehow equivalent to extra virgin olive oil. However, the biological effects of its consumption are poorly described. Here we have explored the effects of its overconsumption on lipid metabolism in a non-human primate model, the common marmoset. Dietary supplementation of marmoset with hyperlipidic diet containing hybrid palm oil for 3 months did not modify plasma lipids levels, but increased glucose levels as compared to the supplementation with African palm oil...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29393361/baicalin-inhibits-pdgf-bb-induced-hepatic-stellate-cell-proliferation-apoptosis-invasion-migration-and-activation-via-the-mir-3595-acsl4-axis
#13
Xiongjian Wu, Fachao Zhi, Weijian Lun, Qiliang Deng, Wendi Zhang
Hepatic fibrosis is a physiological response to liver injury that includes a range of cell types. The pathogenesis of hepatic fibrosis currently focuses on hepatic stellate cell (HSC) activation into muscle fiber cells and fibroblasts. Baicalin is a flavone glycoside. It is the glucuronide of baicalein, which is extracted from the dried roots of Scutellaria baicalensis Georgi. Previous work focused on the anti‑viral, ‑inflammatory and ‑tumor properties of baicalin. However, the potential anti‑fibrotic effects and mechanisms of baicalin are not known...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29391222/micrornas-in-the-pathogenesis-and-treatment-of-progressive-liver-injury-in-nafld-and-liver-fibrosis
#14
Qiaozhu Su, Virender Kumar, Neetu Sud, Ram I Mahato
Non-alcoholic fatty liver disease (NAFLD) increases the risk of various liver injuries, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and ultimately hepatocellular carcinoma (HCC). Ample evidence has suggested that aberrant expression of microRNAs (miRNAs) is functionally involved in the activation of cellular stress, inflammation and fibrogenesis in hepatic cells, including hepatocytes, Kupffer and hepatic stellate cells (HSCs), at different pathological stages of NAFLD and liver fibrosis...
January 31, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29323718/effect-of-mir-182-on-hepatic-fibrosis-induced-by-schistosomiasis-japonica-by-targeting-foxo1-through-pi3k-akt-signaling-pathway
#15
Yu Huang, Xiangxue Fan, Ran Tao, Qiqin Song, Likui Wang, Hongyue Zhang, Hongyan Kong, Jiaquan Huang
The study aimed to investigate the impact of miR-182 and FOXO1 on S. japonica-induced hepatic fibrosis. Microarray analysis was performed to screen out differential expressed miRNAs and mRNAs. Rat hepatic fibrosis model and human hepatocellular cell line LX-2 were used to study the effect of miR-182 and FOXO1. qRT-PCR and Western blot were used to detect the expression of miR-182, FOXO1 or other fibrosis markers. The targeting relationship between FOXO1 and miR-182 was verified by luciferase reporter assay...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29248466/leptin-suppresses-microrna-122-promoter-activity-by-phosphorylation-of-foxo1-in-hepatic-stellate-cell-contributing-to-leptin-promotion-of-mouse-liver-fibrosis
#16
Qing Cao, Xiaofei Zhu, Xuguang Zhai, Li Ji, Fangyun Cheng, Yiqi Zhu, Pengfei Yu, Yajun Zhou
Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA-122 (miR-122) is the most abundant liver-specific miRNA and was demonstrated to inhibit liver fibrosis and reduced HSC proliferation. Our previous study revealed that leptin reduced miR-122 level in HSCs. This study was aimed to investigate whether leptin affected miR-122 promoter and the underlying mechanisms in HSCs. Results showed that leptin inhibited miR-122 promoter activity...
January 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29236317/association-of-rno-mir-183-96-182-cluster-with-diethyinitrosamine-induced-liver-fibrosis-in-wistar-rats
#17
Rajeev Chandel, Roli Saxena, Ashim Das, Jyotdeep Kaur
Chronic liver injury due to various etiological factors including environmental carcinogens results in development of liver fibrosis. Numerous studies showed role of miRNAs in liver fibrosis. In the present study, we determined the rno-miR-183-96-182 cluster expression during hepatic fibrosis induced by diethylnitrosamine (DEN) treated Wistar rats and its association with plasma levels of circulating rno-miR-96, rno-miR-182, rno-miR-183, liver function test and lipid profile, aiming to identify their potential for histological stratification and early diagnosis of liver fibrosis...
May 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29229992/mirna-21-ablation-protects-against-liver-injury-and-necroptosis-in-cholestasis
#18
Marta B Afonso, Pedro M Rodrigues, André L Simão, Maria M Gaspar, Tânia Carvalho, Paula Borralho, Jesús M Bañales, Rui E Castro, Cecília M P Rodrigues
Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas. Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation (BDL) murine model. We aimed to evaluate the role of miR-21 in mediating deleterious processes associated with cholestasis. Mechanistic studies established a functional link between miR-21 and necroptosis through cyclin-dependent kinase 2-associated protein 1 (CDK2AP1). miR-21 expression increased in the liver of primary biliary cholangitis (PBC) patients and BDL wild-type (WT) mice at both 3 and 14 days...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29196165/osteopontin-promotes-collagen-i-synthesis-in-hepatic-stellate-cells-by-mirna-129-5p-inhibition
#19
Yinghua Chen, Yitao Ou, Jiale Dong, Guizhi Yang, Zhi Zeng, Ying Liu, Bing Liu, Weidong Li, Xiaoshun He, Tian Lan
Activation of hepatic stellate cells (HSCs) is an essential event in the initiation and progression of liver fibrosis. HSCs are believed to be the major source of collagen-producing myofibroblasts in fibrotic livers. A key feature in the pathogenesis of liver fibrosis is fibrillar Collagen I (Col 1) deposition. Osteopontin (OPN), an extracellular matrix (ECM) cytokine expressed in HSCs, could drive fibrogenesis by modulating the HSC pro-fibrogenic phenotype and Col 1 expression. Here, we aimed to investigate the molecular mechanism of OPN regulating the activation of HSCs...
January 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29194684/global-microrna-expression-profiling-in-the-liver-biopsies-of-hepatitis-b-virus-infected-patients-suggests-specific-microrna-signatures-for-viral-persistence-and-hepatocellular-injury
#20
Avishek Kumar Singh, Sheetalnath Babasaheb Rooge, Aditi Varshney, Madavan Vasudevan, Ankit Bhardwaj, Senthil Kumar Venugopal, Nirupama Trehanpati, Manoj Kumar, Robert Geffers, Vijay Kumar, Shiv Kumar Sarin
Hepatitis B virus (HBV) can manipulate the microRNA (miRNA) regulatory networks in infected cells to create a permissive environment for viral replication, cellular injury, disease onset, and its progression. The aim of the present study was to understand the miRNA networks and their target genes in the liver of hepatitis B patients involved in HBV replication, liver injury, and liver fibrosis. We investigated differentially expressed miRNAs by microarray in liver biopsy samples from different stages of HBV infection and liver disease (immune-tolerant [n = 8], acute viral hepatitis [n = 8], no fibrosis [n = 16], early [F1+F2, n = 19] or late [F3+F4, n = 14] fibrosis, and healthy controls [n = 7])...
May 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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