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Culprit B cells identified for MS

Janeen R Jordan, Ernest E Moore, Eric L Sarin, Sagar S Damle, Sara B Kashuk, Christopher C Silliman, Anirban Banerjee
Mesenteric lymph is the mechanistic link between splanchnic hypoperfusion and acute lung injury (ALI), but the culprit mediator(s) remains elusive. Previous work has shown that administration of a phospholipase A(2) (PLA(2)) inhibitor attenuated postshock ALI and also identified a non-ionic lipid within the postshock mesenteric lymph (PSML) responsible for polymorphonuclear neutrophil (PMN) priming. Consequently, we hypothesized that gut-derived leukotriene B(4) (LTB(4)) is a key mediator in the pathogenesis of ALI...
April 2008: Journal of Applied Physiology
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