Rupert F G Simpson, Josef Dankiewicz, Grigoris V Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P Wise, Anders M Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R Davies, Niklas Nielsen, Thomas R Keeble
BACKGROUND: Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. METHODS: In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia (33 °C), followed by controlled re-warming, or normothermia with early treatment of fever (body temperature, ≥ 37...
November 15, 2022: Critical Care: the Official Journal of the Critical Care Forum