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https://www.readbyqxmd.com/read/28431841/cognitive-profile-and-disorders-affecting-higher-brain-functions-in-paediatric-patients-with-neurofibromatosis-type-1
#1
E Vaucheret Paz, A López Ballent, C Puga, M J García Basalo, F Baliarda, C Ekonen, R Ilari, G Agosta
INTRODUCTION: Neurofibromatosis type 1 (NF1) is a common neurocutaneous syndrome often associated with specific cognitive deficits that are rarely monitored during follow-up of these patients. OBJECTIVE: The purpose of our study is two-fold. First, we aimed to describe the cognitive profile of patients with NF1 and detect disorders in higher brain functions associated with the disease. Second, we identified the reasons for consultation associated with school performance in these patients...
April 18, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28431197/serum-c-reactive-protein-procalcitonin-and-lactate-dehydrogenase-for-the-diagnosis-of-pancreatic-necrosis
#2
REVIEW
Oluyemi Komolafe, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: The treatment of people with pancreatic necrosis differs from that of people with oedematous pancreatitis. It is important to know the diagnostic accuracy of serum C-reactive protein (CRP), serum procalcitonin, and serum lactate dehydrogenase (LDH) as a triage test for the detection of pancreatic necrosis in people with acute pancreatitis, so that an informed decision can be made as to whether the person with pancreatic necrosis needs further investigations such as computed tomography (CT) scan or magnetic resonance imaging (MRI) scan and treatment for pancreatic necrosis started...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28430294/grn-mutation-in-a-patient-with-a-behavioral-variant-of-frontotemporal-lobar-degeneration-bvftd
#3
Sylwia Walczysková, Pavel Ressner, Šárka Hilscherová, Jaroslav Kotlas, Jiří Konrád, Věnceslava Svobodová
<i>The clinical spectrum of frontotemporal lobar degeneration (FTLD) is characterized by personality changes, language impairment, and executive function deficits. About 40% of FTLD cases have a family history of the disease, and the GRN gene is currently the most frequent genetic determinant. In cases of inherited FTLD with GRN mutations, parkinsonism is often an early sign due to greater grey matter atrophy in the caudate nucleus and bilateral atrophy in the thalamus. We investigated a female patient with signs of frontotemporal lobe atrophy and unilateral caudate nucleus atrophy on MRI...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28430082/a-community-based-survey-on-syrian-refugee-women-s-health-and-its-predictors-in-%C3%A5-anliurfa-turkey
#4
Zeynep Simsek, Nebiye Yentur Doni, Nese Gül Hilali, Gokhan Yildirimkaya
Reproductive characteristics, mental health symptoms, micronutrient deficiencies, and symptoms of sexually transmitted infections (STI) were determined among married Syrian refugee women aged 15-49 years who were living outside of camps in 2015, using probability sampling. Of the 458 participants, 51.3% married before the age of 18 years. Early-age marriages and number of desired children increased after the war. In multivariable analyses, education (adjusted odds ratio [aOR] = 1.2; 95% confidence interval [CI] = 1...
April 21, 2017: Women & Health
https://www.readbyqxmd.com/read/28429816/a-randomised-controlled-trial-to-test-the-effect-of-promoting-caregiver-contingent-talk-on-language-development-in-infants-from-diverse-socioeconomic-status-backgrounds
#5
Michelle McGillion, Julian M Pine, Jane S Herbert, Danielle Matthews
BACKGROUND: Early language skills are critical for later academic success. Lower socioeconomic status (SES) children tend to start school with limited language skills compared to advantaged peers. We test the hypothesis that this is due in part to differences in caregiver contingent talk during infancy (how often the caregiver talks about what is in the focus of the infant's attention). METHODS: In a randomised controlled trial with high and low SES families, 142 11-month olds and their caregivers were randomly allocated to either a contingent talk intervention or a dental health control...
April 21, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28429383/altered-eigenvector-centrality-is-related-to-local-resting-state-network-functional-connectivity-in-patients-with-longstanding-type-1-diabetes-mellitus
#6
Eelco van Duinkerken, Menno M Schoonheim, Richard G IJzerman, Annette C Moll, Jesus Landeira-Fernandez, Martin Klein, Michaela Diamant, Frank J Snoek, Frederik Barkhof, Alle-Meije Wink
INTRODUCTION: Longstanding type 1 diabetes (T1DM) is associated with microangiopathy and poorer cognition. In the brain, T1DM is related to increased functional resting-state network (RSN) connectivity in patients without, which was decreased in patients with clinically evident microangiopathy. Subcortical structure seems affected in both patient groups. How these localized alterations affect the hierarchy of the functional network in T1DM is unknown. Eigenvector centrality mapping (ECM) and degree centrality are graph theoretical methods that allow determining the relative importance (ECM) and connectedness (degree centrality) of regions within the whole-brain network hierarchy...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28426949/agarra-agarran-evidence-of-early-comprehension-of-subject-verb-agreement-in-spanish
#7
Nayeli Gonzalez-Gomez, Lisa Hsin, Isabelle Barrière, Thierry Nazzi, Géraldine Legendre
Studies across many languages (e.g., Dutch, English, Farsi, Spanish, Xhosa) have failed to show early acquisition of subject-verb (SV) agreement, whereas recent studies on French reveal acquisition by 30months of age. Using a similar procedure as in previous French studies, the current study evaluated whether earlier comprehension of SV agreement in (Mexican) Spanish can be revealed when task demands are lowered. Two experiments using a touch-screen pointing task tested comprehension of SV agreement by monolingual Spanish-speaking children growing up in Mexico City between about 3 and 5years of age...
April 17, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28426947/structural-neuroplasticity-of-the-superior-temporal-plane-in-early-and-late-blindness
#8
Hicret Atilgan, Olivier Collignon, Uri Hasson
Blindness is associated with well-documented changes to the morphometry and function of the occipital cortex. By comparison, its impact on the perisylvian regions in the superior temporal plane (STP) is poorly understood, with many studies reporting null findings on this issue. Here we re-approach this question using a morphometric analysis that relied on fine-scale, manual annotation of 13 sub-regions within the STP and that quantified both univariate and multivariate differences in morphometry. We applied these analyses to both cortical thickness (CT) and surface area (SA) data from congenitally and late blind, as compared to two matched sighted control groups...
April 17, 2017: Brain and Language
https://www.readbyqxmd.com/read/28426943/how-strong-is-the-evidence-for-using-blood-biomarkers-alone-to-screen-for-alcohol-consumption-during-pregnancy-a-systematic-review
#9
Helen Howlett, Sarah Abernethy, Nigel W Brown, Judith Rankin, William K Gray
Accurate and early identification of women at risk from alcohol consumption during pregnancy allows education and support programmes to be targeted at those most in need. We aimed to conduct a systematic review to compare the efficacy of blood analysis and maternal self-report in detecting at risk women during pregnancy. This review investigated diagnostic accuracy. We searched four databases (Medline, Embase, Psychinfo and CINAHL) for relevant articles and conducted hand searches of recent issues of key journals in the field...
April 5, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28425775/academic-outcomes-of-multilingual-children-in-australia
#10
Meredith O'Connor, Elodie O'Connor, Joanne Tarasuik, Sarah Gray, Amanda Kvalsvig, Sharon Goldfeld
PURPOSE: The Australian educational system is increasingly challenged to meet the needs of multilingual students, who comprise a fifth of the student population. Within the context of a monolingual English curriculum, multilingual children who enter school not yet English proficient may be at risk of experiencing inequitable educational outcomes. METHOD: We examined the relationship between the timing of multilingual children's acquisition of receptive English vocabulary skills and subsequent reading and numeracy outcomes, as well as factors associated with earlier versus later timing of acquisition...
February 24, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28425742/comparing-and-validating-methods-of-reading-instruction-using-behavioural-and-neural-findings-in-an-artificial-orthography
#11
J S H Taylor, Matthew H Davis, Kathleen Rastle
There is strong scientific consensus that emphasizing print-to-sound relationships is critical when learning to read alphabetic languages. Nevertheless, reading instruction varies across English-speaking countries, from intensive phonic training to multicuing environments that teach sound- and meaning-based strategies. We sought to understand the behavioral and neural consequences of these differences in relative emphasis. We taught 24 English-speaking adults to read 2 sets of 24 novel words (e.g., /buv/, /sig/), written in 2 different unfamiliar orthographies...
April 20, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28424636/the-neural-basis-of-speech-perception-through-lipreading-and-manual-cues-evidence-from-deaf-native-users-of-cued-speech
#12
Mario Aparicio, Philippe Peigneux, Brigitte Charlier, Danielle Balériaux, Martin Kavec, Jacqueline Leybaert
We present here the first neuroimaging data for perception of Cued Speech (CS) by deaf adults who are native users of CS. CS is a visual mode of communicating a spoken language through a set of manual cues which accompany lipreading and disambiguate it. With CS, sublexical units of the oral language are conveyed clearly and completely through the visual modality without requiring hearing. The comparison of neural processing of CS in deaf individuals with processing of audiovisual (AV) speech in normally hearing individuals represents a unique opportunity to explore the similarities and differences in neural processing of an oral language delivered in a visuo-manual vs...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28424614/relationship-between-cognitive-and-sleep-wake-variables-in-asymptomatic-offspring-of-patients-with-late-onset-alzheimer-s-disease
#13
Carolina Abulafia, Bárbara Duarte-Abritta, Mirta F Villarreal, María S Ladrón-de-Guevara, Celeste García, Geraldine Sequeyra, Gustavo Sevlever, Leticia Fiorentini, Karl-Jürgen Bär, Deborah R Gustafson, Daniel E Vigo, Salvador M Guinjoan
Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28424604/mapping-critical-language-sites-in-children-performing-verb-generation-whole-brain-connectivity-and-graph-theoretical-analysis-in-meg
#14
Vahab Youssofzadeh, Brady J Williamson, Darren S Kadis
A classic left frontal-temporal brain network is known to support language processes. However, the level of participation of constituent regions, and the contribution of extra-canonical areas, is not fully understood; this is particularly true in children, and in individuals who have experienced early neurological insult. In the present work, we propose whole-brain connectivity and graph-theoretical analysis of magnetoencephalography (MEG) source estimates to provide robust maps of the pediatric expressive language network...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28419590/cracking-the-neural-code-treating-paralysis-and-the-future-of-bioelectronic-medicine
#15
C Bouton
The human nervous system is a vast network carrying not only sensory and movement information, but also information to and from our organs, intimately linking it to our overall health. Scientists and engineers have been working for decades to tap into this network and 'crack the neural code' by decoding neural signals and learning how to 'speak' the language of the nervous system. Progress has been made in developing neural decoding methods to decipher brain activity and bioelectronic technologies to treat rheumatoid arthritis, paralysis, epilepsy and for diagnosing brain-related diseases such as Parkinson's and Alzheimer's disease...
April 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28419188/interactive-book-reading-to-accelerate-word-learning-by-kindergarten-children-with-specific-language-impairment-identifying-adequate-progress-and-successful-learning-patterns
#16
Holly L Storkel, Rouzana Komesidou, Kandace K Fleming, Rebecca Swinburne Romine
Purpose: The goal of this study was to provide guidance to clinicians on early benchmarks of successful word learning in an interactive book reading treatment and to examine how encoding and memory evolution during treatment contribute to word learning outcomes by kindergarten children with specific language impairment (SLI). Method: Twenty-seven kindergarten children with SLI participated in a preliminary clinical trial using interactive book reading to teach 30 new words...
April 20, 2017: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/28418939/exploring-the-molecular-pathogenesis-and-biomarkers-of-high-risk-oral-premalignant-lesions-on-the-basis-of-long-noncoding-rna-expression-profiling-by-serial-analysis-of-gene-expression
#17
Hongcheng Jia, Xuan Wang, Zheng Sun
Oral premalignant lesions (OPLs) have malignant transformation potential, with no reliable markers available. This study aimed to assess molecular events to identify biomarkers that can reflect high-risk lesions as predictive factors to tailor clinical decision for patients on the basis of long noncoding RNAs (lncRNA) expression profiling by serial analysis of gene expression. The GSE31021 and GSE8127 datasets were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and lncRNAs were identified using the LIMMA package in R language...
April 17, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28418456/mapping-the-early-language-environment-using-all-day-recordings-and-automated-analysis
#18
Jill Gilkerson, Jeffrey A Richards, Steven F Warren, Judith K Montgomery, Charles R Greenwood, D Kimbrough Oller, John H L Hansen, Terrance D Paul
Purpose: This research provided a first-generation standardization of automated language environment estimates, validated these estimates against standard language assessments, and extended on previous research reporting language behavior differences across socioeconomic groups. Method: Typically developing children between 2 to 48 months of age completed monthly, daylong recordings in their natural language environments over a span of approximately 6-38 months...
April 16, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28418329/phoneme-error-pattern-by-heritage-speakers-of-spanish-on-an-english-word-recognition-test
#19
Lu-Feng Shi
BACKGROUND: Heritage speakers acquire their native language from home use in their early childhood. As the native language is typically a minority language in the society, these individuals receive their formal education in the majority language and eventually develop greater competency with the majority than their native language. To date, there have not been specific research attempts to understand word recognition by heritage speakers. It is not clear if and to what degree we may infer from evidence based on bilingual listeners in general...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28418261/preschool-children-s-communication-motor-and-social-development-parents-and-educators-concerns
#20
Sharynne McLeod, Kathryn Crowe, Jane McCormack, Paul White, Yvonne Wren, Elise Baker, Sarah Masso, Sue Roulstone
PURPOSE: During early childhood, it is important to identify which children require intervention before they face the increased demands of school. This study aimed to: (1) compare parents' and educators' concerns, (2) examine inter-rater reliability between parents' and educators' concerns and (3) determine the group difference between level of concern and children's performance on clinical testing. METHOD: Parents and educators of 1205 4- to 5-year-old children in the Sound Start Study completed the Parents' Evaluation of Developmental Status...
April 18, 2017: International Journal of Speech-language Pathology
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