keyword
MENU ▼
Read by QxMD icon Read
search

Glycine receptor

keyword
https://www.readbyqxmd.com/read/29038482/selective-binding-of-choline-by-a-phosphate-coordination-based-triple-helicate-featuring-an-aromatic-box
#1
Chuandong Jia, Wei Zuo, Dong Yang, Yanming Chen, Liping Cao, Radu Custelcean, Jiří Hostaš, Pavel Hobza, Robert Glaser, Yao-Yu Wang, Xiao-Juan Yang, Biao Wu
In nature, proteins have evolved sophisticated cavities tailored for capturing target guests selectively among competitors of similar size, shape, and charge. The fundamental principles guiding the molecular recognition, such as self-assembly and complementarity, have inspired the development of biomimetic receptors. In the current work, we report a self-assembled triple anion helicate (host 2) featuring a cavity resembling that of the choline-binding protein ChoX, as revealed by crystal and density functional theory (DFT)-optimized structures, which binds choline in a unique dual-site-binding mode...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29033788/zinc-as-a-neuromodulator-in-the-central-nervous-system-with-a-focus-on-the-olfactory-bulb
#2
REVIEW
Laura J Blakemore, Paul Q Trombley
The olfactory bulb (OB) is central to the sense of smell, as it is the site of the first synaptic relay involved in the processing of odor information. Odor sensations are first transduced by olfactory sensory neurons (OSNs) before being transmitted, by way of the OB, to higher olfactory centers that mediate olfactory discrimination and perception. Zinc is a common trace element, and it is highly concentrated in the synaptic vesicles of subsets of glutamatergic neurons in some brain regions including the hippocampus and OB...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29033133/natively-unfolded-fg-repeats-stabilize-the-structure-of-the-nuclear-pore-complex
#3
Evgeny Onischenko, Jeffrey H Tang, Kasper R Andersen, Kevin E Knockenhauer, Pascal Vallotton, Carina P Derrer, Annemarie Kralt, Christopher F Mugler, Leon Y Chan, Thomas U Schwartz, Karsten Weis
Nuclear pore complexes (NPCs) are ∼100 MDa transport channels assembled from multiple copies of ∼30 nucleoporins (Nups). One-third of these Nups contain phenylalanine-glycine (FG)-rich repeats, forming a diffusion barrier, which is selectively permeable for nuclear transport receptors that interact with these repeats. Here, we identify an additional function of FG repeats in the structure and biogenesis of the yeast NPC. We demonstrate that GLFG-containing FG repeats directly bind to multiple scaffold Nups in vitro and act as NPC-targeting determinants in vivo...
October 7, 2017: Cell
https://www.readbyqxmd.com/read/29031411/in%C3%A2-vivo-brain-glycine-and-glutamate-concentrations-in-patients-with-first-episode-psychosis-measured-by-echo-time-averaged-proton-magnetic-resonance-spectroscopy-at-4t
#4
Sang-Young Kim, Marc J Kaufman, Bruce M Cohen, J Eric Jensen, Joseph T Coyle, Fei Du, Dost Öngür
BACKGROUND: Accumulating evidence suggests the involvement of abnormal glutamateric neurotransmission and N-methyl-D-aspartate receptor hypofunction in the pathophysiology of psychotic disorders. The purpose of this study was to quantify in vivo glutamate (Glu) and glycine (Gly) levels in patients with first-episode psychosis as well as age-matched healthy control subjects with magnetic resonance spectroscopy (MRS). METHODS: The subjects were 46 patients with first-episode psychosis (20 with a schizophrenia spectrum disorder, 26 with bipolar disorder) and 50 age-matched healthy control subjects...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29024451/activation-of%C3%A2-group-ii-metabotropic-glutamate-receptors-increases-proliferation-but-does-not-influence-neuronal-differentiation-of-a-human-neural-stem-cell-line
#5
Anne Dindler, Morten Blaabjerg, Morad Kamand, Helle Bogetofte, Morten Meyer
The multiple functions of glutamate include regulation of neural development and stem cells. While the importance of the ionotropic glutamate receptors is well established, less is known about the role of metabotropic glutamate receptors (mGluRs). In this study, we examined the effects of pharmacological activation and inhibition of mGluR2/3 on proliferation, differentiation and viability of a human neural stem cell line. Immunofluorescence staining revealed the presence of mGluR2/3 receptors on both proliferating and differentiating stem cells, including cells differentiated into β-tubulin III-positive immature neurons and glial fibrillary acidic protein-positive astrocytes...
October 11, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29019082/loss-of-the-nutrient-sensor-tas1r3-leads-to-reduced-bone-resorption
#6
Michael S Eaton, Nicholas Weinstein, Jordan B Newby, Maggie M Plattes, Hanna E Foster, Jon W Arthur, Taylor D Ward, Stephen R Shively, Ryann Shor, Justin Nathan, Hannah M Davis, Lilian I Plotkin, Eric M Wauson, Brian J Dewar, Aaron Broege, Jonathan W Lowery
The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 (TAS1R1) or TAS1R member 2 (TAS1R2), respectively. It was recently reported that deletion of TAS1R3 expression in Tas1R3 mutant mice leads to increased cortical bone mass but the underlying cellular mechanism leading to this phenotype remains unclear...
October 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29018191/d-serine-released-by-astrocytes-in-brainstem-regulates-breathing-response-to-co2-levels
#7
S Beltrán-Castillo, M J Olivares, R A Contreras, G Zúñiga, I Llona, R von Bernhardi, J L Eugenín
Central chemoreception is essential for adjusting breathing to physiological demands, and for maintaining CO2 and pH homeostasis in the brain. CO2-induced ATP release from brainstem astrocytes stimulates breathing. NMDA receptor (NMDAR) antagonism reduces the CO2-induced hyperventilation by unknown mechanisms. Here we show that astrocytes in the mouse caudal medullary brainstem can synthesize, store, and release D-serine, an agonist for the glycine-binding site of the NMDAR, in response to elevated CO2 levels...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28985719/a-novel-compound-mutation-in-glra1-cause-hyperekplexia-in-a-chinese-boy-a-case-report-and-review-of-the-literature
#8
Zhiliang Yang, Guilian Sun, Fang Yao, Dongying Tao, Binlu Zhu
BACKGROUND: The pathogenesis of hereditary hyperekplexia is thought to involve abnormalities in the glycinergic neurotransmission system, the most of mutations reported in GLRA1. This gene encodes the glycine receptor α1 subunit, which has an extracellular domain (ECD) and a transmembrane domain (TMD) with 4 α-helices (TM1-TM4). CASE PRESENTATION: We investigated the genetic cause of hyperekplexia in a Chinese family with one affected member. Whole-exome sequencing of the 5 candidate genes was performed on the proband patient, and direct sequencing was performed to validate and confirm the detected mutation in other family members...
October 6, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28980941/cerebral-mglur5-availability-contributes-to-elevated-sleep-need-and-behavioral-adjustment-after-sleep-deprivation
#9
Sebastian C Holst, Alexandra Sousek, Katharina Hefti, Sohrab Saberi-Moghadam, Alfred Buck, Simon M Ametamey, Milan Scheidegger, Paul Franken, Anke Henning, Erich Seifritz, Mehdi Tafti, Hans-Peter Landolt
Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to the molecular machinery governing sleep-wake homeostasis. Using positron emission tomography, magnetic resonance spectroscopy, and electroencephalography in humans, we find that increased mGluR5 availability after sleep loss tightly correlates with behavioral and electroencephalographic biomarkers of elevated sleep need...
October 5, 2017: ELife
https://www.readbyqxmd.com/read/28979182/glycine-n-methylation-in-ngr-tagged-nanocarriers-prevents-isoaspartate-formation-and-integrin-binding-without-impairing-cd13-recognition-and-tumor-homing
#10
Angelo Corti, Anna Maria Gasparri, Michela Ghitti, Angelina Sacchi, Francesco Sudati, Martina Fiocchi, Valentina Buttiglione, Laura Perani, Alessandro Gori, Silvia Valtorta, Rosa Maria Moresco, Fabio Pastorino, Mirco Ponzoni, Giovanna Musco, Flavio Curnis
NGR (asparagine-glycine-arginine) is a tumor vasculature-homing peptide motif widely used for the functionalization of drugs, nanomaterials and imaging compounds for cancer treatment and diagnosis. Unfortunately, this motif has a strong propensity to undergo rapid deamidation. This reaction, which converts NGR into isoDGR, is associated with receptor switching from CD13 to integrins, with potentially important manufacturing, pharmacological and toxicological implications. It is found that glycine N-methylation of NGR-tagged nanocarriers completely prevents asparagine deamidation without impairing CD13 recognition...
September 26, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28969000/magnetic-resonance-metabolic-profiling-of-estrogen-receptor-positive-breast-cancer-correlation-with-currently-used-molecular-markers
#11
Ji Soo Choi, Dahye Yoon, Ja Seung Koo, Siwon Kim, Vivian Youngjean Park, Eun-Kyung Kim, Suhkmann Kim, Min Jung Kim
Estrogen receptor (ER)-positive breast cancers overall have a good prognosis, however, some patients suffer relapses and do not respond to endocrine therapy. The purpose of this study was to determine whether there are any correlations between high-resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) metabolic profiles of core needle biopsy (CNB) specimens and the molecular markers currently used in patients with ER-positive breast cancers. The metabolic profiling of CNB samples from 62 ER-positive cancers was performed by HR-MAS MRS...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28966065/involvement-of-neuronal-and-glial-activities-in-control-of-the-extracellular-d-serine-concentrations-by-the-ampa-glutamate-receptor-in-the-mouse-medial-prefrontal-cortex
#12
Sayuri Ishiwata, Asami Umino, Toru Nishikawa
It has been well accepted that d-serine may be an exclusive endogenous coagonist for the N-methyl-d-aspartate (NMDA)-type glutamate receptor in mammalian forebrain regions. We have recently found by using an in vivo dialysis method that an intra-medial prefrontal cortex infusion of S-α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (S-AMPA), a selective AMPA-type glutamate receptor agonist, causes a reduction in the extracellular levels of d-serine in a calcium-permeable AMPA receptor antagonist-sensitive manner...
September 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28963585/effects-of-eugenol-on-respiratory-burst-generation-in-newborn-rat-brainstem-spinal-cord-preparations
#13
Sayumi Kotani, Saki Irie, Masahiko Izumizaki, Hiroshi Onimaru
Eugenol is contained in several plants including clove and is used as an analgesic drug. In the peripheral and central nervous systems, this compound modulates neuronal activity through action on voltage-gated ionic channels and/or transient receptor potential channels. However, it is unknown whether eugenol exerts any effects on the respiratory center neurons in the medulla. We examined the effects of eugenol on respiratory rhythm generation in the brainstem-spinal cord preparation from newborn rat (P0-P3)...
September 29, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28959847/-prediction-of-eta-oligopeptides-antagonists-from-glycine-max-based-on-in-silico-proteolysis
#14
Lian-Sheng Qiao, Lu-di Jiang, Gang-Gang Luo, Fang Lu, Yan-Kun Chen, Ling-Zhi Wang, Gong-Yu Li, Yan-Ling Zhang
Oligopeptides are one of the the key pharmaceutical effective constituents of traditional Chinese medicine(TCM). Systematic study on composition and efficacy of TCM oligopeptides is essential for the analysis of material basis and mechanism of TCM. In this study, the potential anti-hypertensive oligopeptides from Glycine max and their endothelin receptor A (ETA) antagonistic activity were discovered and predicted based on in silico technologies.Main protein sequences of G. max were collected and oligopeptides were obtained using in silico gastrointestinal tract proteolysis...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28959846/-analgesic-effect-and-central-mechanisms-of-cq-prescription-on-cancer-invasion-induced-mirror-image-pain-in-model-mice
#15
Yu-Mao Jiang, Dan-Dan Sun, Zhi-Guo Wang, Tao Li, Xiao-Liang Zhao, Yue Jiao, Yang Liu, Yu-Juan Li, Jing-Feng Ouyang, Dan-Qiao Wang
This study aimed to analyze the analgesic effect and related central mechanisms of CQ prescription on cancer invasion induced mirror image pain (CIIMIP)in model mice.In the study, male BALB/c mice were randomly divided into normal group, operation control group (injected with 0.2 mL inactivated S180 sarcoma cell sap), model group (injected with 0.2 mL S180 sarcoma cell sap on the right leg near the greater trochanter of femur) and CQ prescription low dose group (intraperitoneally injected with CQ prescription 100 mg•kg⁻¹ on the basis of model mice), CQ prescription middle dose group (intraperitoneally injected with CQ prescription 150 mg•kg⁻¹ on the basis of model mice), and CQ prescription high dose group (intraperitoneally injected with CQ prescription 200 mg•kg⁻¹ on the basis of model mice)...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28956357/gly184-of-the-escherichia-coli-camp-receptor-protein-provides-optimal-context-for-both-dna-binding-and-rna-polymerase-interaction
#16
Matt N Hicks, Sanjiva Gunasekara, Jose Serate, Jin Park, Pegah Mosharaf, Yue Zhou, Jin-Won Lee, Hwan Youn
The Escherichia coli cAMP receptor protein (CRP) utilizes the helix-turn-helix motif for DNA binding. The CRP's recognition helix, termed F-helix, includes a stretch of six amino acids (Arg180, Glu181, Thr182, Val183, Gly184, and Arg185) for direct DNA contacts. Arg180, Glu181 and Arg185 are known as important residues for DNA binding and specificity, but little has been studied for the other residues. Here we show that Gly184 is another F-helix residue critical for the transcriptional activation function of CRP...
October 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28955208/nicotinic-acetylcholine-receptor-%C3%AE-9-and-%C3%AE-10-subunits-are-expressed-in-the-brain-of-mice
#17
Olena Lykhmus, Larysa P Voytenko, Katrin S Lips, Ivonne Bergen, Gabriela Krasteva-Christ, Douglas E Vetter, Wolfgang Kummer, Maryna Skok
The α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes acetylcholine, GABA, glycine and serotonin ionotropic receptors. nAChRs containing α9 and α10 subunits are found in the inner ear, dorsal root ganglia and many non-excitable tissues, but their expression in the central nervous system has not been definitely demonstrated. Here we show the presence of both α9 and α10 nAChR subunits in the mouse brain by RT-PCR and immunochemical approaches with a range of nAChR subunit-selective antibodies, which selectivity was demonstrated in the brain preparations of α7-/-, α9-/- and α10-/- mice...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28949296/investigating-molecular-crowding-within-nuclear-pores-using-polarization-palm
#18
Guo Fu, Li-Chun Tu, Anton Zilman, Siegfried M Musser
The key component of the nuclear pore complex (NPC) controlling permeability, selectivity, and the speed of nucleocytoplasmic transport is an assembly of natively unfolded polypeptides, which contain phenylalanine-glycine (FG) binding sites for nuclear transport receptors. The architecture and dynamics of the FG-network have been refractory to characterization due to the paucity of experimental methods able to probe the mobility and density of the FG-polypeptides and embedded macromolecules within intact NPCs...
September 26, 2017: ELife
https://www.readbyqxmd.com/read/28948156/short-poly-glutamine-repeat-in-the-androgen-receptor-in-new-world-monkeys
#19
Chihiro Hiramatsu, Annika Paukner, Hika Kuroshima, Kazuo Fujita, Stephen J Suomi, Miho Inoue-Murayama
The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys)...
December 2017: Meta Gene
https://www.readbyqxmd.com/read/28939329/potential-deficit-from-decreased-cerebellar-granule-cell-migration-in-serine-racemase-deficient-mice-is-reversed-by-increased-expression-of-glun2b-and-elevated-levels-of-nmdar-agonists
#20
He Zhang, Liping Song, Yuhua Chang, Mengjuan Wu, Xiuli Kuang, Haiyan Jiang, Shengzhou Wu
Inward migration of cerebellar granule cells (CGCs) after birth is critical for lamination in the cerebellar cortex. N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NMDAR) tethering CGCs into Bergmann glial fibers mediates the inward movement during the glial-dependent migratory phase. Activation of NMDAR depends on simultaneous binding of the GluN2 subunit by glutamate, and of the GluN1 subunit by d-serine or glycine; d-serine is believed to be an endogenous ligand of NMDAR. We hypothesized that lamination of the cerebellar cortex may be compromised in Srr (the gene for serine racemase (SR)) mutated mice (Srrnull) because of significantly low levels of d-serine per se...
September 20, 2017: Molecular and Cellular Neurosciences
keyword
keyword
80172
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"