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Li Xu, Lefeng Wang, Xinchun Yang, Kuibao Li, Hao Sun, Dapeng Zhang, Hongshi Wang, Weiming Li, Zhuhua Ni, Kun Xia, Yu Liu
BACKGROUND: Large-scale clinical trials have shown that routine monitoring of the platelet function in patients after percutanous coronary intervention (PCI) is not necessary. However, it is still unclear whether patients received high-risk PCI would benefit from a therapy which is guided by a selective platelet function monitoring. This explanatory study sought to assess the benefit of a therapy guided by platelet function monitoring for these patients. METHODS: Acute coronary syndrome (ACS) patients (n = 384) who received high-risk, complex PCI were randomized into two groups...
2014: Chinese Medical Journal
Ziwen Wang, Peng Wei, Lizhong Wang, Qingmin Wang
On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent)...
October 17, 2012: Journal of Agricultural and Food Chemistry
Nenad Ratković, Radoslav Romanović, Aleksandra Jovelić, Branko Gligić, Saso Rafajlovski, Danilo Vojvodić, Slobodan Obradović
BACKGROUND/AIM: Inflammation as a consequence of vascular injury after percutaneous coronary intervention (PCI) is a pathological substrate of restenosis and of its complications. The aim of the study was to examine perprocedural inflammatory response expressed by soluble CD40 ligand (sCD40L) and C-reactive protein (CRP) in patients treated with PCI and dual antiplatelet therapy. METHODS: The experimental group included 52 patients (80.8% men, age 60 +/- 9 years) with angina pectoris treated by PCI (22 urgent PCI) with stent implantation, and dual antiplatelet therapy (tienopiridins and aspirin), according to the current recommendations for the execution of the intervention...
September 2010: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Ching T Hou
We identified many novel oxygenated fatty acids produced from linoleic acid by Bacillus megaterium ALA2: 12,13,17-trihydroxy-9(Z)-octadecenoic acid (12,13,17-THOA); 12,13,16-trihydroxy-9(Z)-octadecenoic acid (12,13,16-THOA); 12-hydroxy-13,16-epoxy-9(Z)-octadecenoic acid; and 12,17;13,17-diepoxy-16-hydroxy-9(Z)-octadecenoic acid. 12,13,17-THOA, the main product, has antiplant pathogenic fungal activity. To develop an industrial process for the production of these new oxygenated fatty acids by strain ALA2, the effect of environmental factors on the production and their impact on the amount of various products were studied...
December 2005: Applied Microbiology and Biotechnology
A Kano
The method for dosing with urokinase (UK) during toxemia of pregnancy, now being studied by us with non- and pregnant rabbits has remained unclarified. The kg/body weight doses determined were 2,500, 5,000, 10,000 and 20,000 in each unit, and the following results were obtained from methods A: a rapid injection, and B: a rapid injection of half the volume followed by drip infusion of the remaining half. The following characteristics of both groups tended to resemble each other: (a) The ELT shortening rate was enhanced with A at doses of 2,500 and 5,000 units/kg, and with B at doses of 10,000 and 20,000 units/kg...
January 1984: Nihon Sanka Fujinka Gakkai Zasshi
A Kano
Pathogenesis of toxemia of pregnancy has been studied of late in terms of coagulation and fibrinolysis, and the results show evidence of hypercoagulability but not of fibrinolysis which has remained unclarified. Our study aims to elucidate the fibrinolytic kinetics of toxemia in normal pregnant women divided into mild and severe types and eclampsia, and also to study changes in the coagulation and fibrinolytic system in toxemia given urokinase. In the affected group the following 1)--3) parameters characteristics were more significant than in other groups...
December 1983: Nihon Sanka Fujinka Gakkai Zasshi
T Arafat, M Saket, R Awad, H Ibrahim, M Saleh, M Gharaibeh, E Sallam, M Shuber
Bioequivalence of Antiplate 75 mg was assessed versus Persantine 75 mg in a two-way crossover study. At the 5% confidence level, no significant difference was found between the area under the plasma concentration-time curves of the two products. The Cmax were comparable for both products. Quality control data including assay, content uniformity, disintegration and dissolution indicated that both products passed the pharmacopoeial requirements, USP XXI and BP 1980, Addendum 1983. It is concluded that Antiplate-75 is bioequivalent to Persantine...
November 1989: International Journal of Clinical Pharmacology, Therapy, and Toxicology
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