antiplated

Fusaramin ( 1 ) was isolated as a mitochondrial inhibitor. However, the fungal producer stops producing 1 , which necessitates us to supply 1 by total synthesis. We proposed the complete stereochemical structure based on the biosynthetic pathway of sambutoxin. We have established concise and robust total synthesis of 1 , enabling us to determine the complete stereochemical structure and to elucidate the structure-activity relationship, and uncover the hidden antiplant pathogenic fungal activity.

The application of antiplant virus agents on leaf surfaces faces challenges due to their vulnerability to wear, instability, and limited duration, which in turn jeopardizes plant health and yield. In recent years, high-aspect-ratio nanomaterials have gained prominence as powerful carriers for disease treatment, thanks to their exceptional penetrability and precise drug delivery capabilities. Here, we synthesized a pH-responsive nanoimmune inducer (CNC-AMO) with strong leaf adhesion through a Schiff base reaction, achieved by grafting amino-oligosaccharides (AMOs) on the surface of aldehyde-based CNC (CNC-CHO)...

Selective autophagy receptors play both proviral and antiviral roles during plant-virus interaction. However, little is known about the balance between such contradictory dual roles of these receptors. Tong et al. have deciphered the temporal regulation of antiviral and antiplant roles of a selective autophagy receptor, a virus-induced small peptide 1 (VISP1).

BACKGROUND: Antisynthetase syndrome is an inflammatory myopathy that is characterized by the presence of anti-aminoacyl-tRNA synthetase antibodies. Only 30% of those who suffer from the disease can be identified. We present three Hispanic cases of antisynthetase syndrome with unusual clinical pictures were extended myositis panel results enable disease diagnosis and treatment. CASE PRESENTATION: A 57-year-old Hispanic/Latino female with an erythematous scaly plaque, unresolved fever and non-immune haemolytic anaemia in whom inpatient work-up for fever of unknown origin was positive for anti-PL12 positive myositis extended panel...

Plant virus disease is the second most prevalent plant diseases and can cause extensive loss in global agricultural economy. Extensive work has been carried out on the development of novel antiplant virus agents for preventing and treating plant virus diseases. In this review, we summarize the achievements of the research and development of new antiviral agents in the recent five years and provide our own perspective on the future development in this highly active research field.

Dufulin is a new type of chiral antiplant virus agent independently developed in China. The present study was conducted to determine the effects of different concentrations of rac-dufulin and dufulin enantiomers (1, 5, and 10 mg/L) on oxidative stress in Tubifex after exposure for 3, 7, and 14 d. Results showed that rac-dufulin and individual enantiomers had no significant effects on total protein content and glutathione reductase activities. Increased superoxide dismutase demonstrated the generation of superoxide anion radical...

Patients with peripheral artery disease are at high-risk for cardiovascular events. Anti-thrombotic treatment is very important for secondary prevention. In symptomatic patients single antiplatelet therapy with clopidogrel or Aspirin is recommended. After peripheral revascularisation transient dual antiplatelet therapy is widely used although there is only little evidence. Following peripheral bypass surgery most patients are treated with single antiplatelet therapy, in some cases (prostetic bypass grafts) dual antiplated therapy can be useful and selected patients with complex venous grafts might profit from anticoagulation with vitamin K antagonists...

BACKGROUND: Large-scale clinical trials have shown that routine monitoring of the platelet function in patients after percutanous coronary intervention (PCI) is not necessary. However, it is still unclear whether patients received high-risk PCI would benefit from a therapy which is guided by a selective platelet function monitoring. This explanatory study sought to assess the benefit of a therapy guided by platelet function monitoring for these patients. METHODS: Acute coronary syndrome (ACS) patients (n = 384) who received high-risk, complex PCI were randomized into two groups...

On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good anti-TMV activity, and some of them exhibited higher antiviral activity than that of commercial Ningnanmycin (perhaps the most successful registered antiplant viral agent)...

BACKGROUND/AIM: Inflammation as a consequence of vascular injury after percutaneous coronary intervention (PCI) is a pathological substrate of restenosis and of its complications. The aim of the study was to examine perprocedural inflammatory response expressed by soluble CD40 ligand (sCD40L) and C-reactive protein (CRP) in patients treated with PCI and dual antiplatelet therapy. METHODS: The experimental group included 52 patients (80.8% men, age 60 +/- 9 years) with angina pectoris treated by PCI (22 urgent PCI) with stent implantation, and dual antiplatelet therapy (tienopiridins and aspirin), according to the current recommendations for the execution of the intervention...

We identified many novel oxygenated fatty acids produced from linoleic acid by Bacillus megaterium ALA2: 12,13,17-trihydroxy-9(Z)-octadecenoic acid (12,13,17-THOA); 12,13,16-trihydroxy-9(Z)-octadecenoic acid (12,13,16-THOA); 12-hydroxy-13,16-epoxy-9(Z)-octadecenoic acid; and 12,17;13,17-diepoxy-16-hydroxy-9(Z)-octadecenoic acid. 12,13,17-THOA, the main product, has antiplant pathogenic fungal activity. To develop an industrial process for the production of these new oxygenated fatty acids by strain ALA2, the effect of environmental factors on the production and their impact on the amount of various products were studied...

The method for dosing with urokinase (UK) during toxemia of pregnancy, now being studied by us with non- and pregnant rabbits has remained unclarified. The kg/body weight doses determined were 2,500, 5,000, 10,000 and 20,000 in each unit, and the following results were obtained from methods A: a rapid injection, and B: a rapid injection of half the volume followed by drip infusion of the remaining half. The following characteristics of both groups tended to resemble each other: (a) The ELT shortening rate was enhanced with A at doses of 2,500 and 5,000 units/kg, and with B at doses of 10,000 and 20,000 units/kg...

Pathogenesis of toxemia of pregnancy has been studied of late in terms of coagulation and fibrinolysis, and the results show evidence of hypercoagulability but not of fibrinolysis which has remained unclarified. Our study aims to elucidate the fibrinolytic kinetics of toxemia in normal pregnant women divided into mild and severe types and eclampsia, and also to study changes in the coagulation and fibrinolytic system in toxemia given urokinase. In the affected group the following 1)--3) parameters characteristics were more significant than in other groups...

Bioequivalence of Antiplate 75 mg was assessed versus Persantine 75 mg in a two-way crossover study. At the 5% confidence level, no significant difference was found between the area under the plasma concentration-time curves of the two products. The Cmax were comparable for both products. Quality control data including assay, content uniformity, disintegration and dissolution indicated that both products passed the pharmacopoeial requirements, USP XXI and BP 1980, Addendum 1983. It is concluded that Antiplate-75 is bioequivalent to Persantine...