Johannes Lübke, Alicia Schmid, Deborah Christen, Hanneke N G Oude Elberink, Lambert F R Span, Marek Niedoszytko, Aleksandra Górska, Magdalena Lange, Karoline V Gleixner, Emir Hadzijusufovic, Alex Stefan, Irena Angelova-Fischer, Roberta Zanotti, Massimiliano Bonifacio, Patrizia Bonadonna, Khalid Shoumariyeh, Nikolas von Bubnoff, Sabine Müller, Cecelia Perkins, Chiara Elena, Luca Malcovati, Hans G Hagglund, Mattias Mattsson, Roberta Parente, Judit Varkonyi, Anna Belloni Fortina, Francesca Caroppo, Knut Brockow, Alexander Zink, Christine Breynaert, Toon Ieven, Akif Selim Yavuz, Michael Doubek, Vito Sabato, Tanja Schug, Karin Hartmann, Massimo Triggiani, Jason Gotlib, Olivier Hermine, Michel Arock, Hanneke C Kluin-Nelemans, Jens Peter Panse, Wolfgang R Sperr, Peter Valent, Andreas Reiter, Juliana Schwaab
Certain laboratory abnormalities correlate with subvariants of systemic mastocytosis (SM) and are often prognostically relevant. To assess the diagnostic and prognostic value of individual serum chemistry parameters in SM, 2607 patients enrolled within the European Competence Network on Mastocytosis (ECNM) and 575 patients enrolled within the German Registry on Eosinophils and Mast Cells (GREM) were analyzed. For screening and diagnosis of SM, tryptase was identified as the most specific serum parameter. For differentiation between indolent and advanced SM (AdvSM), the following serum parameters were most relevant: tryptase, alkaline phosphatase (AP), ß2-microglobulin, lactate dehydrogenase (LDH), albumin, vitamin B12, and C-reactive protein (P<0...
April 9, 2024: Blood Advances