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https://www.readbyqxmd.com/read/29329063/seasonality-of-depressive-symptoms-in-women-but-not-in-men-a-cross-sectional-study-in-the-uk-biobank-cohort
#1
Laura M Lyall, Cathy A Wyse, Carlos A Celis-Morales, Donald M Lyall, Breda Cullen, Daniel Mackay, Joey Ward, Nicholas Graham, Rona J Strawbridge, Jason M R Gill, Amy Ferguson, Mark E S Bailey, Jill P Pell, Annie M Curtis, Daniel J Smith
BACKGROUND: We examined whether seasonal variations in depressive symptoms occurred independently of demographic and lifestyle factors, and were related to change in day length and/or outdoor temperature. METHODS: In a cross-sectional analysis of >150,000 participants of the UK Biobank cohort, we used the cosinor method to assess evidence of seasonality of a total depressive symptoms score and of low mood, anhedonia, tenseness and tiredness scores in women and men...
January 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29326298/smoking-duration-alone-provides-stronger-risk-estimates-of-chronic-obstructive-pulmonary-disease-than-pack-years
#2
Surya P Bhatt, Young-Il Kim, Kathy F Harrington, John E Hokanson, Sharon M Lutz, Michael H Cho, Dawn L DeMeo, James M Wells, Barry J Make, Stephen I Rennard, George R Washko, Marilyn G Foreman, Donald P Tashkin, Robert A Wise, Mark T Dransfield, William C Bailey
BACKGROUND: Cigarette smoking is the strongest risk factor for COPD. Smoking burden is frequently measured in pack-years, but the relative contribution of cigarettes smoked per day versus duration towards the development of structural lung disease, airflow obstruction and functional outcomes is not known. METHODS: We analysed cross-sectional data from a large multicentre cohort (COPDGene) of current and former smokers. Primary outcome was airflow obstruction (FEV1/FVC); secondary outcomes included five additional measures of disease: FEV1, CT emphysema, CT gas trapping, functional capacity (6 min walk distance, 6MWD) and respiratory morbidity (St George's Respiratory Questionnaire, SGRQ)...
January 11, 2018: Thorax
https://www.readbyqxmd.com/read/29281843/liver-injury-in-hemolysis-elevated-liver-enzymes-and-low-platelets-syndrome-measured-by-diffusion-weighted-magnetic-resonance-imaging
#3
David B Nelson, Ambereen Khan, April Bailey, Takeshi Yokoo, Ivan Pedrosa, Donald D McIntire, F Gary Cunningham
OBJECTIVE:  The objective of this study was to evaluate acute liver injury (ALI) detected by diffusion-weighted magnetic resonance imaging (MRI) and the associated laboratory findings in women with hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. STUDY DESIGN:  This was a retrospective, observational study of women with HELLP syndrome defined by serum aspartate aminotransferase (AST) levels ≥100 U/L and thrombocytopenia with platelets ≤100,000/µL...
December 27, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29187730/genome-wide-analysis-in-uk-biobank-identifies-four-loci-associated-with-mood-instability-and-genetic-correlation-with-major-depressive-disorder-anxiety-disorder-and-schizophrenia
#4
Joey Ward, Rona J Strawbridge, Mark E S Bailey, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Laura M Pidgeon, Jonathan Cavanagh, Daniel F Mackay, Jill P Pell, Michael O'Donovan, Valentina Escott-Price, Daniel J Smith
Mood instability is a core clinical feature of affective and psychotic disorders. In keeping with the Research Domain Criteria approach, it may be a useful construct for identifying biology that cuts across psychiatric categories. We aimed to investigate the biological validity of a simple measure of mood instability and evaluate its genetic relationship with several psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, attention deficit hyperactivity disorder (ADHD), anxiety disorder and post-traumatic stress disorder (PTSD)...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29187271/2017-bailey-k-ashford-donald-mackay-and-walter-reed-medal-recipients
#5
American Society Of Tropical Medicine And Hygiene
No abstract text is available yet for this article.
December 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29148627/assessment-of-endpoint-criteria-and-perceived-barriers-during-maximal-cardiorespiratory-fitness-testing-among-pregnant-women
#6
Caitlin M Hesse, Rachel A Tinius, Bailey J Cooley, Alyssa A Olenick, Maire M Blankenship, Donald L Hoover, Jill M Maples
BACKGROUND: A plateau in volume of oxygen consumption (VO2) is the primary indicator for determining if an individual has reached their maximal aerobic capacity. However, secondary criteria can also be used to identify maximal effort (i.e. lactate level, rating of perceived exertion (RPE), percent of age-predicted maximal heart rate (HR) and respiratory exchange ratio (RER)). Age and gender-specific secondary criteria have been developed for the general population, but no secondary criteria have been established for pregnant women...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29093038/internet-gaming-disorder-in-children-and-adolescents
#7
REVIEW
Douglas A Gentile, Kira Bailey, Daphne Bavelier, Jeanne Funk Brockmyer, Hilarie Cash, Sarah M Coyne, Andrew Doan, Donald S Grant, C Shawn Green, Mark Griffiths, Tracy Markle, Nancy M Petry, Sara Prot, Cosette D Rae, Florian Rehbein, Michael Rich, Dave Sullivan, Elizabeth Woolley, Kimberly Young
The American Psychiatric Association recently included Internet gaming disorder (IGD) as a potential diagnosis, recommending that further study be conducted to help illuminate it more clearly. This paper is a summary of the review undertaken by the IGD Working Group as part of the 2015 National Academy of Sciences Sackler Colloquium on Digital Media and Developing Minds. By using measures based on or similar to the IGD definition, we found that prevalence rates range between ∼1% and 9%, depending on age, country, and other sample characteristics...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28960184/fragile-x-syndrome
#8
REVIEW
Randi J Hagerman, Elizabeth Berry-Kravis, Heather Cody Hazlett, Donald B Bailey, Herve Moine, R Frank Kooy, Flora Tassone, Ilse Gantois, Nahum Sonenberg, Jean Louis Mandel, Paul J Hagerman
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism spectrum disorder, and patients can present with severe behavioural alterations, including hyperactivity, impulsivity and anxiety, in addition to poor language development and seizures. FXS is a trinucleotide repeat disorder, in which >200 repeats of the CGG motif in FMR1 leads to silencing of the gene and the consequent loss of its product, fragile X mental retardation 1 protein (FMRP). FMRP has a central role in gene expression and regulates the translation of potentially hundreds of mRNAs, many of which are involved in the development and maintenance of neuronal synaptic connections...
September 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28853718/genetic-correlations-between-intraocular-pressure-blood-pressure-and-primary-open-angle-glaucoma-a-multi-cohort-analysis
#9
Hugues Aschard, Jae H Kang, Adriana I Iglesias, Pirro Hysi, Jessica N Cooke Bailey, Anthony P Khawaja, R Rand Allingham, Allison Ashley-Koch, Richard K Lee, Sayoko E Moroi, Murray H Brilliant, Gadi Wollstein, Joel S Schuman, John H Fingert, Donald L Budenz, Tony Realini, Terry Gaasterland, William K Scott, Kuldev Singh, Arthur J Sit, Robert P Igo, Yeunjoo E Song, Lisa Hark, Robert Ritch, Douglas J Rhee, Vikas Gulati, Shane Haven, Douglas Vollrath, Donald J Zack, Felipe Medeiros, Robert N Weinreb, Ching-Yu Cheng, Daniel I Chasman, William G Christen, Margaret A Pericak-Vance, Yutao Liu, Peter Kraft, Julia E Richards, Bernard A Rosner, Michael A Hauser, Caroline C W Klaver, Cornelia M vanDuijn, Jonathan Haines, Janey L Wiggs, Louis R Pasquale
Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP), while the relation between BP and POAG is controversial. The International Glaucoma Genetics Consortium (n=27 558), the International Consortium on Blood Pressure (n=69 395), and the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (n=37 333), represent genome-wide data sets for IOP, BP traits and POAG, respectively...
November 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28814542/fragile-x-newborn-screening-lessons-learned-from-a-multisite-screening-study
#10
MULTICENTER STUDY
Donald B Bailey, Elizabeth Berry-Kravis, Louise W Gane, Sonia Guarda, Randi Hagerman, Cynthia M Powell, Flora Tassone, Anne Wheeler
BACKGROUND: Delays in the diagnosis of children with fragile X syndrome (FXS) suggest the possibility of newborn screening as a way to identify children earlier. However, FXS does not have a proven treatment that must be provided early, and ethical concerns have been raised about the detection of infants who are carriers. This article summarizes major findings from a multisite, prospective, longitudinal pilot screening study. METHODS: Investigators in North Carolina, California, and Illinois collaborated on a study in which voluntary screening for FXS was offered to parents in 3 birthing hospitals...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28771249/parental-preferences-toward-genomic-sequencing-for-non-medically-actionable-conditions-in-children-a-discrete-choice-experiment
#11
Megan A Lewis, Alex Stine, Ryan S Paquin, Carol Mansfield, Dallas Wood, Christine Rini, Myra I Roche, Cynthia M Powell, Jonathan S Berg, Donald B Bailey
PurposeApplication of whole-exome and whole-genome sequencing is likely to increase in clinical practice, public health contexts, and research. We investigated how parental preference for acquiring information from genome-scale testing is influenced by the characteristics of non-medically actionable genetic disorders in children, as well as whether the preferences differed by gender and between African-American and white respondents.MethodsWe conducted a Web-based discrete-choice experiment with 1,289 parents of young children...
August 3, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28720595/transcription-controls-growth-cell-kinetics-and-cholesterol-supply-to-sustain-acth-responses
#12
Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, Christopher J Kenyon
Chronic ACTH exposure is associated with adrenal hypertrophy and steroidogenesis. The underlying molecular processes in mice have been analysed by microarray, histological and immunohistochemical techniques. Synacthen infused for 2 weeks markedly increased adrenal mass and plasma corticosterone levels. Microarray analysis found greater than 2-fold changes in expression of 928 genes (P < 0.001; 397 up, 531 down). These clustered in pathways involved in signalling, sterol/lipid metabolism, cell proliferation/hypertrophy and apoptosis...
October 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28575260/social-support-social-strain-and-cognitive-function-among-community-dwelling-u-s-chinese-older-adults
#13
Shaoqing Ge, Bei Wu, Donald E Bailey, XinQi Dong
Background: Limited research is available on the relationship between social support, social strain, and cognitive function among community-dwelling U.S. Chinese older adults. This study aims to examine the associations between social support/strain and cognitive outcomes. Methods: Data were drawn from the Population-Based Study of Chinese Elderly (N = 3,159). Cognitive function was measured by a battery of tests including the East Boston Memory Test, the Digit Span Backwards assessment, and the Symbol Digit Modalities Test...
July 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28435479/a-novel-program-for-absn-students-to-generate-interest-in-geriatrics-and-geriatric-nursing-research
#14
Jennifer Mewshaw, Donald E Bailey, Kristie A Porter, Amber L Anderson, Ruth A Anderson, Andrew L Burd, Cathleen Colón-Emeric, Kirsten N Corazzini
The current shortage of nurse researchers in geriatrics adversely affects the capacity of nurses to conduct research to advance the evidence-based care of older adults. In an effort to generate interest in geriatrics and geriatric nursing research, the Duke University School of Nursing designed a summer internship for four students enrolled in the accelerated baccalaureate nursing (ABSN) program. This paper describes the experience of these ABSN students and the staff and faculty who worked with them. The program design, staff and faculty experiences, benefits and challenges, as well as recommendations for future programs are discussed...
June 2017: Journal of Nursing Education and Practice
https://www.readbyqxmd.com/read/28362683/thrombin-generation-profiles-as-predictors-of-symptomatic-venous-thromboembolism-after-trauma-a-prospective-cohort-study
#15
Myung S Park, Grant M Spears, Kent R Bailey, Ailing Xue, Michael J Ferrara, Amy Headlee, Sabtir K Dhillon, Donald H Jenkins, Scott P Zietlow, William S Harmsen, Aneel A Ashrani, John A Heit
BACKGROUND: Reliable biomarkers predictive of venous thromboembolism (VTE) after acute trauma are uncertain. The objective of the study was to identify risk factors for symptomatic VTE after trauma, including individual plasma coagulome characteristics as reflected by thrombin generation. METHODS: In a prospective, case-cohort study, trauma patients were enrolled over the 4.5-year period, 2011 to 2015. Blood was collected by venipuncture into 3.2% trisodium citrate at 0, 6, 12, 24, and 72 hours after injury and at hospital discharge...
September 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28277289/randomized-trial-of-an-uncertainty-self-management-telephone-intervention-for-patients-awaiting-liver-transplant
#16
Donald E Bailey, Cristina C Hendrix, Karen E Steinhauser, Karen M Stechuchak, Laura S Porter, Julie Hudson, Maren K Olsen, Andrew Muir, Sarah Lowman, Andrea DiMartini, Laurel Williams Salonen, James A Tulsky
OBJECTIVE: We tested an uncertainty self-management telephone intervention (SMI) with patients awaiting liver transplant and their caregivers. METHODS: Participants were recruited from four transplant centers and completed questionnaires at baseline, 10, and 12 weeks from baseline (generally two and four weeks after intervention delivery, respectively). Dyads were randomized to either SMI (n=56) or liver disease education (LDE; n=59), both of which involved six weekly telephone sessions...
March 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28251931/sleep-characteristics-modify-the-association-of-genetic-predisposition-with-obesity-and-anthropometric-measurements-in-119-679-uk-biobank-participants
#17
Carlos Celis-Morales, Donald M Lyall, Yibing Guo, Lewis Steell, Daniel Llanas, Joey Ward, Daniel F Mackay, Stephany M Biello, Mark Es Bailey, Jill P Pell, Jason Mr Gill
Background: Obesity is a multifactorial condition influenced by genetics, lifestyle, and environment.Objective: We investigated whether the association of a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI) and waist circumference (WC) was modified by sleep characteristics.Design: This study included cross-sectional data from 119,859 white European adults, aged 37-73 y, participating in the UK Biobank. Interactions of GPRS-obesity and sleep characteristics (sleep duration, chronotype, day napping, and shift work) with their effects on BMI and WC were investigated...
April 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28237927/efficient-hardware-implementation-for-fingerprint-image-enhancement-using-anisotropic-gaussian-filter
#18
Tariq Mahmood Khan, Donald G Bailey, Mohammad A U Khan, Yinan Kong
A real-time image filtering technique is proposed which could result in faster implementation for fingerprint image enhancement. One major hurdle associated with fingerprint filtering techniques is the expensive nature of their hardware implementations. To circumvent this, a modified anisotropic Gaussian filter is efficiently adopted in hardware by decomposing the filter into two orthogonal Gaussians and an oriented line Gaussian. An architecture is developed for dynamically controlling the orientation of the line Gaussian filter...
May 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28231416/feasibility-of-combining-common-data-elements-across-studies-to-test-a-hypothesis
#19
Elizabeth J Corwin, Shirley M Moore, Andrea Plotsky, Margaret M Heitkemper, Susan G Dorsey, Drenna Waldrop-Valverde, Donald E Bailey, Sharron L Docherty, Joanne D Whitney, Carol M Musil, Cynthia M Dougherty, Donna J McCloskey, Joan K Austin, Patricia A Grady
PURPOSE: The purpose of this article is to describe the outcomes of a collaborative initiative to share data across five schools of nursing in order to evaluate the feasibility of collecting common data elements (CDEs) and developing a common data repository to test hypotheses of interest to nursing scientists. This initiative extended work already completed by the National Institute of Nursing Research CDE Working Group that successfully identified CDEs related to symptoms and self-management, with the goal of supporting more complex, reproducible, and patient-focused research...
May 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28096516/newborn-sequencing-in-genomic-medicine-and-public-health
#20
RANDOMIZED CONTROLLED TRIAL
Jonathan S Berg, Pankaj B Agrawal, Donald B Bailey, Alan H Beggs, Steven E Brenner, Amy M Brower, Julie A Cakici, Ozge Ceyhan-Birsoy, Kee Chan, Flavia Chen, Robert J Currier, Dmitry Dukhovny, Robert C Green, Julie Harris-Wai, Ingrid A Holm, Brenda Iglesias, Galen Joseph, Stephen F Kingsmore, Barbara A Koenig, Pui-Yan Kwok, John Lantos, Steven J Leeder, Megan A Lewis, Amy L McGuire, Laura V Milko, Sean D Mooney, Richard B Parad, Stacey Pereira, Joshua Petrikin, Bradford C Powell, Cynthia M Powell, Jennifer M Puck, Heidi L Rehm, Neil Risch, Myra Roche, Joseph T Shieh, Narayanan Veeraraghavan, Michael S Watson, Laurel Willig, Timothy W Yu, Tiina Urv, Anastasia L Wise
The rapid development of genomic sequencing technologies has decreased the cost of genetic analysis to the extent that it seems plausible that genome-scale sequencing could have widespread availability in pediatric care. Genomic sequencing provides a powerful diagnostic modality for patients who manifest symptoms of monogenic disease and an opportunity to detect health conditions before their development. However, many technical, clinical, ethical, and societal challenges should be addressed before such technology is widely deployed in pediatric practice...
February 2017: Pediatrics
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