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https://www.readbyqxmd.com/read/27913647/diversity-of-antiviral-igg-effector-activities-observed-in-hiv-infected-and-vaccinated-subjects
#1
Yunda Huang, Guido Ferrari, Galit Alter, Donald N Forthal, John C Kappes, George K Lewis, J Christopher Love, Bhavesh Borate, Linda Harris, Kelli Greene, Hongmei Gao, Tran B Phan, Gary Landucci, Brittany A Goods, Karen G Dowell, Hao D Cheng, Chris Bailey-Kellogg, David C Montefiori, Margaret E Ackerman
Diverse Ab effector functions mediated by the Fc domain have been commonly associated with reduced risk of infection in a growing number of nonhuman primate and human clinical studies. This study evaluated the anti-HIV Ab effector activities in polyclonal serum samples from HIV-infected donors, VAX004 vaccine recipients, and healthy HIV-negative subjects using a variety of primary and cell line-based assays, including Ab-dependent cellular cytotoxicity (ADCC), Ab-dependent cell-mediated viral inhibition, and Ab-dependent cellular phagocytosis...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27911419/methods-of-soil-resampling-to-monitor-changes-in-the-chemical-concentrations-of-forest-soils
#2
Gregory B Lawrence, Ivan J Fernandez, Paul W Hazlett, Scott W Bailey, Donald S Ross, Thomas R Villars, Angelica Quintana, Rock Ouimet, Michael R McHale, Chris E Johnson, Russell D Briggs, Robert A Colter, Jason Siemion, Olivia L Bartlett, Olga Vargas, Michael R Antidormi, Mary M Koppers
Recent soils research has shown that important chemical soil characteristics can change in less than a decade, often the result of broad environmental changes. Repeated sampling to monitor these changes in forest soils is a relatively new practice that is not well documented in the literature and has only recently been broadly embraced by the scientific community. The objective of this protocol is therefore to synthesize the latest information on methods of soil resampling in a format that can be used to design and implement a soil monitoring program...
November 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27822316/developmental-profiles-of-infants-with-an-fmr1-premutation
#3
Anne C Wheeler, John Sideris, Randi Hagerman, Elizabeth Berry-Kravis, Flora Tassone, Donald B Bailey
BACKGROUND: Emerging evidence suggests that a subset of FMR1 premutation carriers is at an increased risk for cognitive, emotional, and medical conditions. However, because the premutation is rarely diagnosed at birth, the early developmental trajectories of children with a premutation are not known. METHODS: This exploratory study examined the cognitive, communication, and social-behavioral profiles of 26 infants with a premutation who were identified through participation in a newborn screening for fragile X syndrome pilot study...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27768656/origins-and-importance-of-the-joint-trauma-system
#4
Donald H Jenkins, Jeffrey A Bailey
No abstract text is available yet for this article.
November 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27760082/age-at-natural-menopause-genetic-risk-score-in-relation-to-age-at-natural-menopause-and-primary-open-angle-glaucoma-in-a-us-based-sample
#5
Louis R Pasquale, Hugues Aschard, Jae H Kang, Jessica N Cooke Bailey, Sara Lindström, Daniel I Chasman, William G Christen, R Rand Allingham, Allison Ashley-Koch, Richard K Lee, Sayoko E Moroi, Murray H Brilliant, Gadi Wollstein, Joel S Schuman, John Fingert, Donald L Budenz, Tony Realini, Terry Gaasterland, Douglas Gaasterland, William K Scott, Kuldev Singh, Arthur J Sit, Robert P Igo, Yeunjoo E Song, Lisa Hark, Robert Ritch, Douglas J Rhee, Vikas Gulati, Shane Havens, Douglas Vollrath, Donald J Zack, Felipe Medeiros, Robert N Weinreb, Margaret A Pericak-Vance, Yutao Liu, Peter Kraft, Julia E Richards, Bernard A Rosner, Michael A Hauser, Jonathan L Haines, Janey L Wiggs
OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their association with ANM or POAG. METHODS: Using data from the Nurses' Health Study (7,143 women), we validated the ANM weighted genetic risk score in relation to self-reported ANM. Subsequently, to assess the relation with POAG, we used data from 2,160 female POAG cases and 29,110 controls in the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (NEIGHBORHOOD), which consists of 8 datasets with imputed genotypes to 5...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27711066/corrigendum-adjuvant-dependent-innate-and-adaptive-immune-signatures-of-risk-of-sivmac251-acquisition
#6
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
No abstract text is available yet for this article.
October 6, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27692491/patient-and-family-communication-during-consultation-visits-the-effects-of-a-decision-aid-for-treatment-decision-making-for-localized-prostate-cancer
#7
Lixin Song, Christina Tyler, Margaret F Clayton, Eleanor Rodgiriguez-Rassi, Latorya Hill, Jinbing Bai, Raj Pruthi, Donald E Bailey
OBJECTIVE: To analyze the effects of a decision aid on improving patients' and family members' information giving and question asking during consultations for prostate cancer treatment decision-making. METHODS: This study is a secondary analysis of archived audio-recorded real-time consultation visits with participants from a randomized clinical trial. Participants were randomly assigned into three groups: TD-intervention targeted patient-only; TS-intervention targeted patients and family members; and control-a handout on staying healthy during treatment...
September 23, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27661856/assessing-the-association-of-mitochondrial-genetic-variation-with-primary-open-angle-glaucoma-using-gene-set-analyses
#8
Anthony P Khawaja, Jessica N Cooke Bailey, Jae Hee Kang, R Rand Allingham, Michael A Hauser, Murray Brilliant, Donald L Budenz, William G Christen, John Fingert, Douglas Gaasterland, Terry Gaasterland, Peter Kraft, Richard K Lee, Paul R Lichter, Yutao Liu, Felipe Medeiros, Syoko E Moroi, Julia E Richards, Tony Realini, Robert Ritch, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Douglas Vollrath, Gadi Wollstein, Donald J Zack, Kang Zhang, Margaret Pericak-Vance, Robert N Weinreb, Jonathan L Haines, Louis R Pasquale, Janey L Wiggs
Purpose: Recent studies indicate that mitochondrial proteins may contribute to the pathogenesis of primary open-angle glaucoma (POAG). In this study, we examined the association between POAG and common variations in gene-encoding mitochondrial proteins. Methods: We examined genetic data from 3430 POAG cases and 3108 controls derived from the combination of the GLAUGEN and NEIGHBOR studies. We constructed biological-system coherent mitochondrial nuclear-encoded protein gene-sets by intersecting the MitoCarta database with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database...
September 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27537254/a-common-variant-in-mir182-is-associated-with-primary-open-angle-glaucoma-in-the-neighborhood-consortium
#9
Yutao Liu, Jessica Cooke Bailey, Inas Helwa, W Michael Dismuke, Jingwen Cai, Michelle Drewry, Murray H Brilliant, Donald L Budenz, William G Christen, Daniel I Chasman, John H Fingert, Douglas Gaasterland, Terry Gaasterland, Mae O Gordon, Robert P Igo, Jae H Kang, Michael A Kass, Peter Kraft, Richard K Lee, Paul Lichter, Sayoko E Moroi, Anthony Realini, Julia E Richards, Robert Ritch, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Yeunjoo E Song, Douglas Vollrath, Robert Weinreb, Felipe Medeiros, Gadi Wollstein, Donald J Zack, Kang Zhang, Margaret A Pericak-Vance, Pedro Gonzalez, W Daniel Stamer, John Kuchtey, Rachel W Kuchtey, R Rand Allingham, Michael A Hauser, Louis R Pasquale, Jonathan L Haines, Janey L Wiggs
PURPOSE: Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). METHODS: Using the NEIGHBORHOOD data set (3853 cases/33,480 controls with European ancestry), we first assessed the relation between 85 variants in 76 MIR genes and overall POAG. Subtype-specific analyses were performed in high-tension glaucoma (HTG) and normal-tension glaucoma subsets...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27533911/origins-and-importance-of-the-joint-trauma-system
#10
Donald H Jenkins, Jeffrey Bailey
No abstract text is available yet for this article.
August 16, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27526258/parental-intentions-to-enroll-children-in-a-voluntary-expanded-newborn-screening-program
#11
Ryan S Paquin, Holly L Peay, Lisa M Gehtland, Megan A Lewis, Donald B Bailey
BACKGROUND AND OBJECTIVES: Nearly all babies in the United States are tested at birth for rare, serious, and treatable disorders through mandatory state newborn screening (NBS). Recently, there have been calls for an expanded, voluntary model to facilitate early diagnosis and treatment of a wider range of disorders. We applied the reasoned action framework to examine parental intentions to participate in voluntary expanded screening. METHODS: We recruited a national cohort of recent and expectant parents living in the U...
October 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27486851/recommendations-of-common-data-elements-to-advance-the-science-of-self-management-of-chronic-conditions
#12
Shirley M Moore, Rachel Schiffman, Drenna Waldrop-Valverde, Nancy S Redeker, Donna Jo McCloskey, Miyong T Kim, Margaret M Heitkemper, Barbara J Guthrie, Susan G Dorsey, Sharron L Docherty, Debra Barton, Donald E Bailey, Joan K Austin, Patricia Grady
PURPOSE: Common data elements (CDEs) are increasingly being used by researchers to promote data sharing across studies. The purposes of this article are to (a) describe the theoretical, conceptual, and definition issues in the development of a set of CDEs for research addressing self-management of chronic conditions; (b) propose an initial set of CDEs and their measures to advance the science of self-management; and (c) recommend implications for future research and dissemination. DESIGN AND METHODS: Between July 2014 and December 2015 the directors of the National Institute of Nursing Research (NINR)-funded P20 and P30 centers of excellence and NINR staff met in a series of telephone calls and a face-to-face NINR-sponsored meeting to select a set of recommended CDEs to be used in self-management research...
September 2016: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/27284980/risk-factors-for-venous-thromboembolism-after-acute-trauma-a-population-based-case-cohort-study
#13
Myung S Park, Sarah E Perkins, Grant M Spears, Aneel A Ashrani, Cynthia L Leibson, Christine M Boos, William S Harmsen, Donald H Jenkins, Kent R Bailey, Karla V Ballman, John A Heit
BACKGROUND: Predictors of venous thromboembolism (VTE) after trauma are uncertain. OBJECTIVE: To identify independent predictors of VTE after acute trauma. METHODS: Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident VTE within 92days after hospitalization for acute trauma over the 18-year period, 1988-2005. We also identified all Olmsted County residents hospitalized for acute trauma over this time period and chose one to two residents frequency-matched to VTE cases on sex, event year group and ICD-9-CM trauma code predictive of surgery...
August 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27239761/adjuvant-dependent-innate-and-adaptive-immune-signatures-of-risk-of-sivmac251-acquisition
#14
Monica Vaccari, Shari N Gordon, Slim Fourati, Luca Schifanella, Namal P M Liyanage, Mark Cameron, Brandon F Keele, Xiaoying Shen, Georgia D Tomaras, Erik Billings, Mangala Rao, Amy W Chung, Karen G Dowell, Chris Bailey-Kellogg, Eric P Brown, Margaret E Ackerman, Diego A Vargas-Inchaustegui, Stephen Whitney, Melvin N Doster, Nicolo Binello, Poonam Pegu, David C Montefiori, Kathryn Foulds, David S Quinn, Mitzi Donaldson, Frank Liang, Karin Loré, Mario Roederer, Richard A Koup, Adrian McDermott, Zhong-Min Ma, Christopher J Miller, Tran B Phan, Donald N Forthal, Matthew Blackburn, Francesca Caccuri, Massimiliano Bissa, Guido Ferrari, Vaniambadi Kalyanaraman, Maria G Ferrari, DeVon Thompson, Marjorie Robert-Guroff, Silvia Ratto-Kim, Jerome H Kim, Nelson L Michael, Sanjay Phogat, Susan W Barnett, Jim Tartaglia, David Venzon, Donald M Stablein, Galit Alter, Rafick-Pierre Sekaly, Genoveffa Franchini
A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)-HIV and gp120 alum decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution of alum with the more immunogenic MF59 adjuvant is under consideration for the next efficacy human trial. We found here that an ALVAC-simian immunodeficiency virus (SIV) and gp120 alum (ALVAC-SIV + gp120) equivalent vaccine, but not an ALVAC-SIV + gp120 MF59 vaccine, was efficacious in delaying the onset of SIVmac251 in rhesus macaques, despite the higher immunogenicity of the latter adjuvant...
July 2016: Nature Medicine
https://www.readbyqxmd.com/read/27168124/adolescent-depression-in-the-arab-region-a-systematic-literature-review
#15
Latefa A Dardas, Donald E Bailey, Leigh Ann Simmons
Adolescent depression is a primary cause of global disability and burden with considerable variability across countries in its prevalence, diagnosis, management, and prognosis. No systematic reviews have been published on adolescent depression in Arab countries despite the unique sociocultural background that can play a major role in shaping Arab depressed adolescents' prognosis and response to treatment. The purpose of this study was to provide such a review with the goal of identifying the necessary foundations for culturally competent mental health care practices to address the unique needs of Arab adolescents and their families...
May 11, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27156778/evaluation-of-a-peer-mentoring-program-for-early-career-gerontological-nursing-faculty-and-its-potential-for-application-to-other-fields-in-nursing-and-health-sciences
#16
Abraham A Brody, Linda Edelman, Elena O Siegel, Victoria Foster, Donald E Bailey, Ashley Leak Bryant, Stewart M Bond
BACKGROUND: As the retirement rate of senior nursing faculty increases, the need to implement new models for providing mentorship to early career academics will become key to developing and maintaining an experienced faculty. PURPOSE: This evaluation of a peer mentorship program for predoctoral and postdoctoral gerontological nurses examined its efficacy, utility, and potential for improvement. METHODS: A web-based survey was developed, implemented, and completed by 22 mentees and 17 mentors (71% and 61% response rates, respectively) as part of the evaluation...
July 2016: Nursing Outlook
https://www.readbyqxmd.com/read/27103599/alzheimer-disease-genetic-risk-factor-apoe-e4-and-cognitive-abilities-in-111-739-uk-biobank-participants
#17
Donald M Lyall, Joey Ward, Stuart J Ritchie, Gail Davies, Breda Cullen, Carlos Celis, Mark E S Bailey, Jana Anderson, Jon Evans, Daniel F Mckay, Andrew M Mcintosh, Naveed Sattar, Daniel J Smith, Ian J Deary, Jill P Pell
BACKGROUND: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases. OBJECTIVE: we tested whether any association with APOE e4 status on cognitive ability was larger in older ages or in those with cardiometabolic diseases. SUBJECTS: UK Biobank includes over 500,000 middle- and older aged adults who have undergone detailed medical and cognitive phenotypic assessment...
July 2016: Age and Ageing
https://www.readbyqxmd.com/read/27064619/adaptive-challenges-rising-from-the-life-context-of-african-american-caregiving-grandmothers-with-diabetes-a-pilot-study
#18
Dana Carthron, Donald E Bailey, Ruth Anderson
To understand the challenges arising from the context within which diabetic African-American caregiving grandmothers self-manage their diabetes we used the Adaptive Leadership Framework. Additionally, challenges to retaining this population in a longitudinal study were examined. In this exploratory, longitudinal, qualitative pilot study, data were collected at five time-points over 18 months. We coded the data using content analysis and conducted the within-case and cross-case analyses using data matrices. Lack of awareness of available resources, represented a technical challenge within the life context of these grandmothers and the remaining three themes: family upheaval; priority setting (with subthemes of difficulty meeting basic needs and competing demands); and self-silencing and self-sacrifice represented adaptive challenges...
September 1, 2015: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/26966976/development-of-a-competence-based-spine-surgery-fellowship-curriculum-set-of-learning-objectives-in-canada
#19
Jeremie Larouche, Albert J M Yee, Veronica Wadey, Henry Ahn, Douglas M Hedden, Hamilton Hall, Robert Broad, Chris Bailey, Andrew Nataraj, Charles Fisher, Sean Christie, Michael Fehlings, Paul J Moroz, Jacques Bouchard, Timothy Carey, Michael Chapman, Donald Chow, Kris Lundine, Iain Dommisse, Joel Finkelstein, Richard Fox, Michael Goytan, John Hurlbert, Eric Massicotte, Jerome Paquet, Jan Splawinski, Eve Tsai, Eugene Wai, Brian Wheelock, Scott Paquette
STUDY DESIGN: Modified-Delphi expert consensus method. OBJECTIVE: The aim of this study was to develop competence-based spine fellowship curricula as a set of learning goals through expert consensus methodology in order to provide an educational tool for surgical educators and trainees. Secondarily, we aimed to determine potential differences among specialties in their rating of learning objectives to defined curriculum documents. SUMMARY OF BACKGROUND DATA: There has been recent interest in competence-based education in the training of future surgeons...
March 2016: Spine
https://www.readbyqxmd.com/read/26961978/family-communication-and-cascade-testing-for-fragile-x-syndrome
#20
Melissa Raspa, Anne Edwards, Anne C Wheeler, Ellen Bishop, Donald B Bailey
A total of 679 families who had at least one child with fragile X syndrome (FXS) were recruited from a research registry to participate in a survey examining cascade testing and communication about FXS. Families had a total of 1117 children (804 males, 313 females). Most families (84 %) had tested all of their children. The main reason for not testing, which did not differ by gender or age of the child, was that the child did not show signs of FXS (68 %). Families talked with their children about FXS occasionally (47 %) although 16 % said they do not talk about it...
October 2016: Journal of Genetic Counseling
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