keyword
MENU ▼
Read by QxMD icon Read
search

baileys, d

keyword
https://www.readbyqxmd.com/read/29772011/induction-of-influenza-specific-local-cd8-t-cells-in-the-respiratory-tract-after-aerosol-delivery-of-vaccine-antigen-or-virus-in-the-babraham-inbred-pig
#1
Katie Tungatt, Garry Dolton, Sophie B Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A Hammond, John J Miles, David K Cole, Alain Townsend, Mick Bailey, Pierre J Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K Sewell
There is increasing evidence that induction of local immune responses is a key component of effective vaccines. For respiratory pathogens, for example tuberculosis and influenza, aerosol delivery is being actively explored as a method to administer vaccine antigens. Current animal models used to study respiratory pathogens suffer from anatomical disparity with humans. The pig is a natural and important host of influenza viruses and is physiologically more comparable to humans than other animal models in terms of size, respiratory tract biology and volume...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29767701/microbiome-mediated-effects-of-the-mediterranean-diet-on-inflammation
#2
Melisa A Bailey, Hannah D Holscher
The Mediterranean diet pattern is increasingly associated with improved metabolic health. Two mechanisms by which consuming a Mediterranean diet pattern may contribute to improved metabolic health are modulation of the gastrointestinal (GI) microbiota and reduction of metabolic endotoxemia. Metabolic endotoxemia, defined as a 2- to 3-fold increase in circulating levels of bacterial endotoxin, has been proposed as a cause of inflammation during metabolic dysfunction. As the largest source of endotoxins in the human body, the GI microbiota represents a crucial area for research on strategies for reducing endotoxemia...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29760442/cross-ancestry-genome-wide-association-analysis-of-corneal-thickness-strengthens-link-between-complex-and-mendelian-eye-diseases
#3
Adriana I Iglesias, Aniket Mishra, Veronique Vitart, Yelena Bykhovskaya, René Höhn, Henriët Springelkamp, Gabriel Cuellar-Partida, Puya Gharahkhani, Jessica N Cooke Bailey, Colin E Willoughby, Xiaohui Li, Seyhan Yazar, Abhishek Nag, Anthony P Khawaja, Ozren Polašek, David Siscovick, Paul Mitchell, Yih Chung Tham, Jonathan L Haines, Lisa S Kearns, Caroline Hayward, Yuan Shi, Elisabeth M van Leeuwen, Kent D Taylor, Pieter Bonnemaijer, Jerome I Rotter, Nicholas G Martin, Tanja Zeller, Richard A Mills, Sandra E Staffieri, Jost B Jonas, Irene Schmidtmann, Thibaud Boutin, Jae H Kang, Sionne E M Lucas, Tien Yin Wong, Manfred E Beutel, James F Wilson, André G Uitterlinden, Eranga N Vithana, Paul J Foster, Pirro G Hysi, Alex W Hewitt, Chiea Chuen Khor, Louis R Pasquale, Grant W Montgomery, Caroline C W Klaver, Tin Aung, Norbert Pfeiffer, David A Mackey, Christopher J Hammond, Ching-Yu Cheng, Jamie E Craig, Yaron S Rabinowitz, Janey L Wiggs, Kathryn P Burdon, Cornelia M van Duijn, Stuart MacGregor
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758355/alcohol-and-opioid-use-in-chronic-pain-a-cross-sectional-examination-of-differences-in-functioning-based-on-misuse-status
#4
Kevin E Vowles, Katie Witkiewitz, Melissa Pielech, Karlyn A Edwards, Mindy L McEntee, Robert W Bailey, Lena Bolling, Mark D Sullivan
Opioid misuse is regularly associated with disrupted functioning in those with chronic pain. Less work has examined whether alcohol misuse may also interfere with functioning. This study examined frequency of opioid and alcohol misuse in 131 individuals (61.1% female) prescribed opioids for the treatment of chronic pain. Participants completed an anonymous survey online, consisting of measures of pain, functioning, and opioid and alcohol misuse. Cut-scores were used to categorize individuals according to substance misuse status; individuals were categorized as follows: 35...
May 11, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29757011/thermal-inactivation-of-shiga-toxin-producing-escherichia-coli-in-ground-beef-with-varying-fat-content
#5
Jagpinder S Brar, Jolena N Waddell, Matthew Bailey, Sydney Corkran, Carmen Velasquez, Vijay K Juneja, Manpreet Singh
Decimal reduction time ( D-value) was calculated for six non-O157 Shiga toxin-producing Escherichia coli (STEC) in a laboratory medium and ground beef. For the laboratory medium, an overnight culture of each strain of STEC was divided into 10-mL sample bags and heated in a water bath for a specific time on the basis of the temperatures. Survival curves were generated by plotting the surviving bacterial population against time, and a linear-log primary model was used to estimate the D-values from survival curves...
May 14, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29750070/deciphering-the-sexual-diploid-members-of-the-boechera-suffrutescens-complex-brassicaceae-boechereae
#6
David P Morin, Patrick J Alexander, James B Beck, Michael D Windham, C Donovan Bailey
Boechera is a model genus that is of particular interest for understanding apomixis due to the presence of numerous apomictic diploid lineages that are tightly correlated with hybridisation events. Boechera includes many narrowly distributed endemics and apomictic hybrid lineages that obscure morphological boundaries amongst taxa. In this study, we focus on the Boechera suffrutescens complex, a phylogenetically well-supported but taxonomically complex north-western United States clade whose diploid species currently include the widespread B...
2018: PhytoKeys
https://www.readbyqxmd.com/read/29749838/learning-gains-from-a-recurring-teach-and-question-homework-assignment-in-a-general-biology-course-using-reciprocal-peer-tutoring-outside-class
#7
E G Bailey, D Baek, J Meiling, C Morris, N Nelson, N S Rice, S Rose, P Stockdale
Providing students with one-on-one interaction with instructors is a big challenge in large courses. One solution is to have students interact with their peers during class. Reciprocal peer tutoring (RPT) is a more involved interaction that requires peers to alternate the roles of "teacher" and "student." Theoretically, advantages for peer tutoring include the verbalization and questioning of information and the scaffolded exploration of material through social and cognitive interaction...
June 2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29749794/molecular-cytogenetics-guides-massively-parallel-sequencing-of-a-radiation-induced-chromosome-translocation-in-human-cells
#8
Michael N Cornforth, Pavana Anur, Nicholas Wang, Erin Robinson, F Andrew Ray, Joel S Bedford, Bradford D Loucas, Eli S Williams, Myron Peto, Paul Spellman, Rahul Kollipara, Ralf Kittler, Joe W Gray, Susan M Bailey
Chromosome rearrangements are large-scale structural variants that are recognized drivers of oncogenic events in cancers of all types. Cytogenetics allows for their rapid, genome-wide detection, but does not provide gene-level resolution. Massively parallel sequencing (MPS) promises DNA sequence-level characterization of the specific breakpoints involved, but is strongly influenced by bioinformatics filters that affect detection efficiency. We sought to characterize the breakpoint junctions of chromosomal translocations and inversions in the clonal derivatives of human cells exposed to ionizing radiation...
May 11, 2018: Radiation Research
https://www.readbyqxmd.com/read/29747384/daily-dietary-intake-patterns-improve-after-visiting-a-food-pantry-among-food-insecure-rural-midwestern-adults
#9
Breanne N Wright, Regan L Bailey, Bruce A Craig, Richard D Mattes, Lacey McCormack, Suzanne Stluka, Lisa Franzen-Castle, Becky Henne, Donna Mehrle, Dan Remley, Heather A Eicher-Miller
Emergency food pantries provide food at no cost to low-resource populations. The purpose of this study was to evaluate single-day dietary intake patterns before and after visiting a food pantry among food-secure and food-insecure pantry clients. This observational cohort study comprised a paired, before-and-after design with a pantry visit as the intervention. Participants ( n = 455) completed a demographic and food security assessment, and two 24-h dietary recalls. Adult food security was measured using the U...
May 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29746403/amish-eye-study-baseline-spectral-domain-optical-coherence-tomography-characteristics-of-age-related-macular-degeneration
#10
Muneeswar G Nittala, Yeunjoo E Song, Rebecca Sardell, Larry D Adams, Samuel Pan, Swetha B Velaga, Violet Horst, Debra Dana, Laura Caywood, Renee Laux, Denise Fuzzell, Sarada Fuzzell, William K Scott, Jessica N Cooke Bailey, Robert P Igo, Jonathan Haines, Margaret A Pericak-Vance, SriniVas R Sadda, Dwight Stambolian
PURPOSE: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). METHODS: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50-99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus autofluorescence, infrared imaging, and color fundus photography...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29745351/evaluation-of-the-effectiveness-of-a-latrine-intervention-in-the-reduction-of-childhood-diarrhoeal-health-in-nyando-district-kisumu-county-kenya
#11
C Babb, N Makotsi, I Heimler, R C Bailey, R C Hershow, P Masanga, S D Mehta
Community-led total sanitation (CLTS) is an intervention that strives to end the practice of open defaecation. This study measured the effectiveness of CLTS in Nyando District by examining the association between community open defaecation-free (ODF) status and childhood diarrhoeal illness. A cross-sectional study design was used among households with children ⩽5 years old to ascertain information on acute diarrhoea in the past year (outcome), sanitation and health behaviours. Water testing was conducted to determine Escherichia coli and turbidity levels for 55 water sources...
May 10, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29734332/downsizing-a-long-term-precipitation-network-using-a-quantitative-approach-to-inform-difficult-decisions
#12
Mark B Green, John L Campbell, Ruth D Yanai, Scott W Bailey, Amey S Bailey, Nicholas Grant, Ian Halm, Eric P Kelsey, Lindsey E Rustad
The design of a precipitation monitoring network must balance the demand for accurate estimates with the resources needed to build and maintain the network. If there are changes in the objectives of the monitoring or the availability of resources, network designs should be adjusted. At the Hubbard Brook Experimental Forest in New Hampshire, USA, precipitation has been monitored with a network established in 1955 that has grown to 23 gauges distributed across nine small catchments. This high sampling intensity allowed us to simulate reduced sampling schemes and thereby evaluate the effect of decommissioning gauges on the quality of precipitation estimates...
2018: PloS One
https://www.readbyqxmd.com/read/29726071/a-prospective-randomised-multi-centre-study-of-the-impact-of-ga-68-psma-pet-ct-imaging-for-staging-high-risk-prostate-cancer-prior-to-curative-intent-surgery-or-radiotherapy-propsma-study-clinical-trial-protocol
#13
Michael S Hofman, Declan G Murphy, Scott G Williams, Tatenda Nzenza, Alan Herschtal, Richard De Abreu Lourenco, Dale L Bailey, Ray Budd, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk
INTRODUCTION: Accurate staging of patients with prostate cancer is important for therapeutic decision making. Relapse following surgery or radiotherapy of curative intent is not uncommon and, in part, represents a failure of staging with current diagnostic imaging techniques to detect disease spread. Prostate-specific-membrane-antigen (PSMA) positron emission tomography / computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high contrast...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29719257/csf1r-macrophages-sustain-pancreatic-tumor-growth-through-t-cell-suppression-and-maintenance-of-key-gene-programs-that-define-the-squamous-subtype
#14
Juliana B Candido, Jennifer P Morton, Peter Bailey, Andrew D Campbell, Saadia A Karim, Thomas Jamieson, Laura Lapienyte, Aarthi Gopinathan, William Clark, Ewan J McGhee, Jun Wang, Monica Escorcio-Correia, Raphael Zollinger, Rozita Roshani, Lisa Drew, Loveena Rishi, Rebecca Arkell, T R Jeffry Evans, Colin Nixon, Duncan I Jodrell, Robert W Wilkinson, Andrew V Biankin, Simon T Barry, Frances R Balkwill, Owen J Sansom
Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent immunotherapy and has a dense desmoplastic stroma, and most patients present with advanced metastatic disease. We reveal that macrophages are the dominant leukocyte population both in human PDAC stroma and autochthonous models, with an important functional contribution to the squamous subtype of human PDAC. We targeted macrophages in a genetic PDAC model using AZD7507, a potent selective inhibitor of CSF1R. AZD7507 caused shrinkage of established tumors and increased mouse survival in this difficult-to-treat model...
May 1, 2018: Cell Reports
https://www.readbyqxmd.com/read/29706668/food-consumption-patterns-and-micronutrient-density-of-complementary-foods-consumed-by-infants-fed-commercially-prepared-baby-foods
#15
Kathleen C Reidy, Regan Lucas Bailey, Denise M Deming, Lynda O'Neill, B Thomas Carr, Ruta Lesniauskas, Wendy Johnson
Nutrition is critically important in the first 1000 days, and while most American babies are fed commercial baby foods, there is little or no evidence from nationally representative data to understand the implications of such consumption. We used 24-hour dietary recall data for 505 infants from The Feeding Infants and Toddlers Study to describe food consumption patterns and micronutrient density of complementary foods consumed by infants fed commercially prepared baby food fruit, vegetables, and dinners and compared with those eaten by nonconsumers of these products...
March 2018: Nutrition Today
https://www.readbyqxmd.com/read/29695381/pulmonary-capillary-wedge-pressure-patterns-during-exercise-predict-exercise-capacity-and-incident-heart-failure
#16
Aaron S Eisman, Ravi V Shah, Bishnu P Dhakal, Paul P Pappagianopoulos, Luke Wooster, Cole Bailey, Thomas F Cunningham, Kathryn M Hardin, Aaron L Baggish, Jennifer E Ho, Rajeev Malhotra, Gregory D Lewis
BACKGROUND: Single measurements of left ventricular filling pressure at rest lack sensitivity for identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on exertion. We hypothesized that exercise hemodynamic measurements (ie, changes in pulmonary capillary wedge pressure [PCWP] indexed to cardiac output [CO]) may more sensitively differentiate HFpEF and non-HFpEF disease states, reflect aerobic capacity, and forecast heart failure outcomes in individuals with normal PCWP at rest...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29694816/azithromycin-to-reduce-childhood-mortality-in-sub-saharan-africa
#17
RANDOMIZED CONTROLLED TRIAL
Jeremy D Keenan, Robin L Bailey, Sheila K West, Ahmed M Arzika, John Hart, Jerusha Weaver, Khumbo Kalua, Zakayo Mrango, Kathryn J Ray, Catherine Cook, Elodie Lebas, Kieran S O'Brien, Paul M Emerson, Travis C Porco, Thomas M Lietman
BACKGROUND: We hypothesized that mass distribution of a broad-spectrum antibiotic agent to preschool children would reduce mortality in areas of sub-Saharan Africa that are currently far from meeting the Sustainable Development Goals of the United Nations. METHODS: In this cluster-randomized trial, we assigned communities in Malawi, Niger, and Tanzania to four twice-yearly mass distributions of either oral azithromycin (approximately 20 mg per kilogram of body weight) or placebo...
April 26, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29691387/fetal-demise-and-failed-antibody-therapy-during-zika-virus-infection-of-pregnant-macaques
#18
Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29685122/treatment-of-pancreatic-ductal-adenocarcinoma-with-tumor-antigen-specific-targeted-delivery-of-paclitaxel-loaded-plga-nanoparticles
#19
Shu-Ta Wu, Anthony J Fowler, Corey B Garmon, Adam B Fessler, Joshua D Ogle, Kajal R Grover, Bailey C Allen, Chandra D Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A Ogle, Pinku Mukherjee
BACKGROUND: Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not significantly improve overall survival rate. It is highly desirable to advance the therapeutic efficacy of chemotherapeutic drugs by targeting their delivery and increasing accumulation at the tumor site. MUC1 is a membrane-tethered glycoprotein that is aberrantly overexpressed in > 80% of PDA thus making it an attractive antigenic target...
April 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29680676/loaded-gun-involvement-among-opioid-users
#20
Michael D Stein, Shannon R Kenney, Bradley J Anderson, Genie L Bailey
INTRODUCTION: Despite ample research examining how alcohol use relates to gun involvement, little is known about the relationship between opioids and gun involvement. In the current study, we examined correlates of gun possession, accessibility, and related behaviors in an opioid dependent sample. METHODS: Between October 2016 and April 2017, we surveyed persons entering a brief, inpatient opioid detoxification (n = 386) and 51 contemporaneous persons seeking alcohol detoxification at the same facility in Massachusetts and recorded their lifetime experiences with gun involvement...
April 16, 2018: Drug and Alcohol Dependence
keyword
keyword
80159
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"