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https://www.readbyqxmd.com/read/28736445/dietary-fat-and-total-energy-intake-modifies-the-effect-of-genetic-profile-risk-score-on-obesity-evidence-from-48-170-uk-biobank-participants
#1
C A Celis-Morales, D M Lyall, S Gray, L Steell, J Anderson, S Iliodromiti, P Welsh, Y Guo, F Petermann, D F Mackay, M E S Bailey, J Pell, J M R Gill, N Sattar
BACKGROUND: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study. METHODS: This study included cross-sectional data from 48 170 white European adults, aged 37-73 years, participating on the UK Biobank...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28733112/distinctions-in-gene-specific-changes-in-dna-methylation-in-response-to-folic-acid-supplementation-between-women-with-normal-weight-and-obesity
#2
Hea Jin Park, Lynn B Bailey, Deanna C Shade, Dorothy B Hausman, Natalie M Hohos, Richard B Meagher, Gail Pa Kauwell, Richard D Lewis, Alicia K Smith
BACKGROUND/OBJECTIVES: Obesity and maternal folate deficiency are associated with increased risk for neural tube defects (NTDs). Limited knowledge exists on the impact of folate status or obesity on DNA methylation of genes related to NTD risk and folate metabolism. SUBJECTS/METHODS: Women (18-35y) with normal weight (NW; BMI 18.5-24.9kg/m(2); n=12) and obesity (OB; BMI >30kg/m(2); n=6) were provided FA (800μg/d) for 8-weeks. Serum folate concentration and changes in DNA methylation across 2098 CpG sites in 91 genes related to NTD risk and folate metabolism were examined...
July 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28732035/vaccine-induced-immune-responses-against-both-gag-and-env-improve-control-of-simian-immunodeficiency-virus-replication-in-rectally-challenged-rhesus-macaques
#3
Mauricio A Martins, Young C Shin, Lucas Gonzalez-Nieto, Aline Domingues, Martin J Gutman, Helen S Maxwell, Iris Castro, Diogo M Magnani, Michael Ricciardi, Nuria Pedreño-Lopez, Varian Bailey, Dillon Betancourt, John D Altman, Matthias Pauthner, Dennis R Burton, Benjamin von Bredow, David T Evans, Maoli Yuan, Christopher L Parks, Keisuke Ejima, David B Allison, Eva Rakasz, Glen N Barber, Saverio Capuano, Jeffrey D Lifson, Ronald C Desrosiers, David I Watkins
The ability to control lentivirus replication may be determined, in part, by the extent to which individual viral proteins are targeted by the immune system. Consequently, defining the antigens that elicit the most protective immune responses may facilitate the design of effective HIV-1 vaccines. Here we vaccinated four groups of rhesus macaques with a heterologous vector prime/boost/boost/boost (PBBB) regimen expressing the following simian immunodeficiency virus (SIV) genes: env, gag, vif, rev, tat, and nef (Group 1); env, vif, rev, tat, and nef (Group 2); gag, vif, rev, tat, and nef (Group 3); or vif, rev, tat, and nef (Group 4)...
July 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28727009/effects-of-energy-supplementation-on-energy-losses-and-nitrogen-balance-of-steers-fed-green-chopped-wheat-pasture-i-calorimetry
#4
A L Shreck, P J Ebert, E A Bailey, J S Jennings, K D Casey, B E Meyer, N A Cole
Cattle grazing wheat pasture in the southern Great Plains are sometimes fed an energy supplement; however, the benefits of supplementation on nutrient balance, energy metabolism, and greenhouse gas emissions have not been elucidated. Therefore, we used 10 British crossbred steers (206 ± 10.7 kg initial BW) in a respiration calorimetry study to evaluate the effects of energy supplementation on energy losses, N balance, and nutrient digestibility of steers fed green-chopped wheat forage. The study design was an incomplete replicated 4 × 4 Latin square with treatments in a 2 × 2 factorial arrangement...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725399/optimizing-performance-of-nonparametric-species-richness-estimators-under-constrained-sampling
#5
Harshana Rajakaruna, D Andrew R Drake, Farrah T Chan, Sarah A Bailey
Understanding the functional relationship between the sample size and the performance of species richness estimators is necessary to optimize limited sampling resources against estimation error. Nonparametric estimators such as Chao and Jackknife demonstrate strong performances, but consensus is lacking as to which estimator performs better under constrained sampling. We explore a method to improve the estimators under such scenario. The method we propose involves randomly splitting species-abundance data from a single sample into two equally sized samples, and using an appropriate incidence-based estimator to estimate richness...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28722569/mass-azithromycin-and-malaria-parasitemia-in-niger-results-from-a-community-randomized-trial
#6
Kieran S O'Brien, Sun Y Cotter, Abdou Amza, Boubacar Kadri, Baido Nassirou, Nicole E Stoller, Zhaoxia Zhou, Chris Cotter, Sheila K West, Robin L Bailey, Philip J Rosenthal, Bruce D Gaynor, Travis C Porco, Thomas M Lietman
Studies designed to determine the effects of mass administration of azithromycin on trachoma have suggested that mass azithromycin distributions may also reduce the prevalence of malaria. These studies have typically examined the impact of a small number of treatments over short durations. In this prespecified substudy of a cluster-randomized trial for trachoma, we compared malaria parasitemia prevalence in 24 communities in Niger randomized to receive either annual or biannual mass azithromycin distributions over 3 years...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28707937/first-searches-for-axions-and-axionlike-particles-with-the-lux-experiment
#7
D S Akerib, S Alsum, C Aquino, H M Araújo, X Bai, A J Bailey, J Balajthy, P Beltrame, E P Bernard, A Bernstein, T P Biesiadzinski, E M Boulton, P Brás, D Byram, S B Cahn, M C Carmona-Benitez, C Chan, A A Chiller, C Chiller, A Currie, J E Cutter, T J R Davison, A Dobi, J E Y Dobson, E Druszkiewicz, B N Edwards, C H Faham, S R Fallon, S Fiorucci, R J Gaitskell, V M Gehman, C Ghag, K R Gibson, M G D Gilchriese, C R Hall, M Hanhardt, S J Haselschwardt, S A Hertel, D P Hogan, M Horn, D Q Huang, C M Ignarra, R G Jacobsen, W Ji, K Kamdin, K Kazkaz, D Khaitan, R Knoche, N A Larsen, C Lee, B G Lenardo, K T Lesko, A Lindote, M I Lopes, A Manalaysay, R L Mannino, M F Marzioni, D N McKinsey, D-M Mei, J Mock, M Moongweluwan, J A Morad, A St J Murphy, C Nehrkorn, H N Nelson, F Neves, K O'Sullivan, K C Oliver-Mallory, K J Palladino, E K Pease, L Reichhart, C Rhyne, S Shaw, T A Shutt, C Silva, M Solmaz, V N Solovov, P Sorensen, S Stephenson, T J Sumner, M Szydagis, D J Taylor, W C Taylor, B P Tennyson, P A Terman, D R Tiedt, W H To, M Tripathi, L Tvrznikova, S Uvarov, V Velan, J R Verbus, R C Webb, J T White, T J Whitis, M S Witherell, F L H Wolfs, J Xu, K Yazdani, S K Young, C Zhang
The first searches for axions and axionlike particles with the Large Underground Xenon experiment are presented. Under the assumption of an axioelectric interaction in xenon, the coupling constant between axions and electrons g_{Ae} is tested using data collected in 2013 with an exposure totaling 95 live days ×118  kg. A double-sided, profile likelihood ratio statistic test excludes g_{Ae} larger than 3.5×10^{-12} (90% C.L.) for solar axions. Assuming the Dine-Fischler-Srednicki-Zhitnitsky theoretical description, the upper limit in coupling corresponds to an upper limit on axion mass of 0...
June 30, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28705897/cas9-mediated-excision-of-nematostella-brachyury-disrupts-endoderm-development-pharynx-formation-and-oral-aboral-patterning
#8
Marc D Servetnick, Bailey Steinworth, Leslie S Babonis, David Simmons, Miguel Salinas-Saavedra, Mark Q Martindale
The mesoderm was a key novelty in animal evolution, though we understand little of how mesoderm arose. brachyury, the founding member of the T-box gene family, is a key gene in chordate mesoderm development. However, the brachyury gene was present in the common ancestor of fungi and animals, long before mesoderm appeared. To explore ancestral roles of brachyury prior to the evolution of definitive mesoderm, we excised the gene using CRISPR/Cas9 in the diploblastic cnidarian Nematostella vectensisNvbrachyury is normally expressed in precursors of the pharynx, which separates endoderm from ectoderm...
July 13, 2017: Development
https://www.readbyqxmd.com/read/28703290/the-association-between-peri-operative-acute-risk-change-arc-and-long-term-survival-after-cardiac-surgery
#9
T G Coulson, M Bailey, C M Reid, L Tran, D V Mullany, J A Smith, D Pilcher
Acute risk change has been described as the difference in calculated mortality risk between the pre-operative and postoperative periods of cardiac surgery. We aimed to assess whether this was associated with long-term survival after cardiac surgery. We retrospectively analysed 22,570 cardiac surgical patients, with minimum and maximum follow-up of 1.0 and 6.7 years. Acute risk change was calculated as the arithmetic difference between pre- and postoperative mortality risk. 'Rising risk' represented an increase in risk from pre- to postoperative phase...
July 13, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28699886/interleukin-1-inhibition-chronic-kidney-disease-mineral-and-bone-disorder-and-physical-function%C3%A2
#10
Kristen L Nowak, Adriana Hung, Talat Alp Ikizler, Heather Farmer-Bailey, Natjalie Salas-Cruz, Sudipa Sarkar, Andrew Hoofnagle, Zhiying You, Michel Chonchol
OBJECTIVE: Epidemiologic studies have suggested a link between chronic systemic inflammation and chronic kidney disease-mineral and bone disorder (CKD-MBD). Additionally, declining renal function is associated with worsening physical and cognitive function, which may potentially be explained by systemic inflammation, CKD-MBD, or both. We hypothesized that inhibiting inflammation with an interleukin-1 (IL-1) trap would improve markers of CKD-MBD as well as physical/cognitive function in patients with moderate-to-severe CKD...
July 12, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28696768/limits-on-spin-dependent-wimp-nucleon-cross-section-obtained-from-the-complete-lux-exposure
#11
D S Akerib, S Alsum, H M Araújo, X Bai, A J Bailey, J Balajthy, P Beltrame, E P Bernard, A Bernstein, T P Biesiadzinski, E M Boulton, P Brás, D Byram, S B Cahn, M C Carmona-Benitez, C Chan, A A Chiller, C Chiller, A Currie, J E Cutter, T J R Davison, A Dobi, J E Y Dobson, E Druszkiewicz, B N Edwards, C H Faham, S R Fallon, S Fiorucci, R J Gaitskell, V M Gehman, C Ghag, M G D Gilchriese, C R Hall, M Hanhardt, S J Haselschwardt, S A Hertel, D P Hogan, M Horn, D Q Huang, C M Ignarra, R G Jacobsen, W Ji, K Kamdin, K Kazkaz, D Khaitan, R Knoche, N A Larsen, C Lee, B G Lenardo, K T Lesko, A Lindote, M I Lopes, A Manalaysay, R L Mannino, M F Marzioni, D N McKinsey, D-M Mei, J Mock, M Moongweluwan, J A Morad, A St J Murphy, C Nehrkorn, H N Nelson, F Neves, K O'Sullivan, K C Oliver-Mallory, K J Palladino, E K Pease, L Reichhart, C Rhyne, S Shaw, T A Shutt, C Silva, M Solmaz, V N Solovov, P Sorensen, S Stephenson, T J Sumner, M Szydagis, D J Taylor, W C Taylor, B P Tennyson, P A Terman, D R Tiedt, W H To, M Tripathi, L Tvrznikova, S Uvarov, V Velan, J R Verbus, R C Webb, J T White, T J Whitis, M S Witherell, F L H Wolfs, J Xu, K Yazdani, S K Young, C Zhang
We present experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from the total 129.5  kg yr exposure acquired by the Large Underground Xenon experiment (LUX), operating at the Sanford Underground Research Facility in Lead, South Dakota (USA). A profile likelihood ratio analysis allows 90% C.L. upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of σ_{n}=1.6×10^{-41}  cm^{2} (σ_{p}=5×10^{-40}  cm^{2}) at 35  GeV c^{-2}, almost a sixfold improvement over the previous LUX spin-dependent results...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28694349/the-linguistic-and-interactional-factors-impacting-recognition-and-dispatch-in-emergency-calls-for-out-of-hospital-cardiac-arrest-a-mixed-method-linguistic-analysis-study-protocol
#12
Marine Riou, Stephen Ball, Teresa A Williams, Austin Whiteside, Kay L O'Halloran, Janet Bray, Gavin D Perkins, Peter Cameron, Daniel M Fatovich, Madoka Inoue, Paul Bailey, Deon Brink, Karen Smith, Phillip Della, Judith Finn
INTRODUCTION: Emergency telephone calls placed by bystanders are crucial to the recognition of out-of-hospital cardiac arrest (OHCA), fast ambulance dispatch and initiation of early basic life support. Clear and efficient communication between caller and call-taker is essential to this time-critical emergency, yet few studies have investigated the impact that linguistic factors may have on the nature of the interaction and the resulting trajectory of the call. This research aims to provide a better understanding of communication factors impacting on the accuracy and timeliness of ambulance dispatch...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28692407/overdose-history-is-associated-with-post-detoxification-treatment-preference-for-persons-with-opioid-use-disorder
#13
Michael D Stein, Jessica N Flori, Megan M Risi, Micah T Conti, Bradley J Anderson, Genie L Bailey
BACKGROUND: Without aftercare treatment, persons discharged from short-term inpatient detoxification for opioid use disorder are at high risk of relapse. In previous work, those who were recently homeless or had pending legal problems were more likely to prefer residential treatment for aftercare. Here, based on clinical experience, we hypothesize that a particular clinical factor, surviving an opioid overdose, will be associated with aftercare preference. METHODS: Between May and December 2015, we surveyed consecutive persons seeking inpatient opioid detoxification...
July 10, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28686083/ischemic-preconditioning-enhances-critical-power-during-a-3-minute-all-out-cycling-test
#14
Patrick J Griffin, Richard A Ferguson, Conor Gissane, Stephen J Bailey, Stephen D Patterson
This study tested the hypothesis that ischemic preconditioning (IPC) would increase critical power (CP) during a 3 minute all-out cycling test. Twelve males completed two 3 minute all-out cycling tests, in a crossover design, separated by 7 days. These tests were preceded by IPC (4 x 5 minute intervals at 220 mmHg bilateral leg occlusion) or SHAM treatment (4 x 5 minute intervals at 20 mmHg bilateral leg occlusion). CP was calculated as the mean power output during the final 30 s of the 3 minute test with W' taken as the total work done above CP...
July 7, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28673827/the-impact-of-spine-stability-on-cervical-spinal-cord-injury-with-respect-to-demographics-management-and-outcome-a-prospective-cohort-from-a-national-sci-registry
#15
Jérôme Paquet, Carly S Rivers, Dilinuer Kuerban, Joel Finkelstein, Jin W Tee, Vanessa K Noonan, Brian K Kwon, R John Hurlbert, Sean Christie, Eve C Tsai, Henry Ahn, Brian Drew, Christopher S Bailey, Daryl R Fourney, Najmedden Attabib, Michael G Johnson, Michael G Fehlings, Stefan Parent, Marcel F Dvorak
BACKGROUND CONTEXT: Emergent surgery for patients with a traumatic spinal cord injury (SCI) is seen as the gold standard in acute management. However, optimal treatment for those with the clinical diagnosis of central cord syndrome (CCS) is less clear and classic definitions of CCS do not identify a unique population of patients. PURPOSE: To test the authors' hypothesis that spine stability can identify a unique group of patients with regards to demographics, management, and outcomes, which classic CCS definitions do not...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28673774/development-functional-characterization-and-validation-of-methodology-for-gmp-compliant-manufacture-of-phagocytic-macrophages-a-novel-cellular-therapeutic-for-liver-cirrhosis
#16
Alasdair R Fraser, Chloe Pass, Paul Burgoyne, Anne Atkinson, Laura Bailey, Audrey Laurie, Neil W A McGowan, Akib Hamid, Joanna K Moore, Benjamin J Dwyer, Marc L Turner, Stuart J Forbes, John D M Campbell
BACKGROUND AIMS: Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration of macrophages has been shown to reduce inflammation and drive fibrotic scar breakdown and tissue repair in relevant models. This therapeutic approach is being assessed for safety and feasibility in a first-in-human trial (MAcrophages Therapy for liver CirrHosis [MATCH] trial). METHODS: We outline the development and validation phases of GMP production...
June 30, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28657340/icrp-publication-134-occupational-intakes-of-radionuclides-part-2
#17
F Paquet, M R Bailey, R W Leggett, J Lipsztein, T P Fell, T Smith, D Nosske, K F Eckerman, V Berkovski, E Ansoborlo, A Giussani, W E Bolch, J D Harrison
No abstract text is available yet for this article.
December 2016: Annals of the ICRP
https://www.readbyqxmd.com/read/28656541/prevalence-and-correlates-of-smoking-among-low-income-adults-residing-in-new-york-city-public-housing-developments-2015
#18
A Feinberg, P M Lopez, K Wyka, N Islam, L Seidl, E Drackett, A Mata, J Pinzon, M R Baker, J Lopez, C Trinh-Shevrin, D Shelley, Z Bailey, K A Maybank, L E Thorpe
To guide targeted cessation and prevention programming, this study assessed smoking prevalence and described sociodemographic, health, and healthcare use characteristics of adult smokers in public housing. Self-reported data were analyzed from a random sample of 1664 residents aged 35 and older in ten New York City public housing developments in East/Central Harlem. Smoking prevalence was 20.8%. Weighted log-binomial models identified to be having Medicaid, not having a personal doctor, and using health clinics for routine care were positively associated with smoking...
June 27, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28653339/fibrinogen-concentration-and-use-of-fibrinogen-supplementation-with-cryoprecipitate-in-patients-with-critical-bleeding-receiving-massive-transfusion-a-bi-national-cohort-study
#19
Zoe K McQuilten, Michael Bailey, Peter A Cameron, Simon J Stanworth, Kylie Venardos, Erica M Wood, D James Cooper
We aimed to compare hypofibrinogenaemia prevalence in major bleeding patients across all clinical contexts, fibrinogen supplementation practice, and explore the relationship between fibrinogen concentrations and mortality. This cohort study included all adult patients from 20 hospitals across Australia and New Zealand who received massive transfusion between April 2011 and October 2015. Of 3566 patients, 2829 (79%) had fibrinogen concentration recorded, with a median first and lowest concentration of 2·0 g/l (interquartile range [IQR] 1·5-2·7) and 1·8 g/l (IQR 1·3-2·4), respectively...
June 27, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28652290/imaging-pain-relief-in-osteoarthritis-ipro-protocol-of-a-double-blind-randomised-controlled-mechanistic-study-assessing-pain-relief-and-prediction-of-duloxetine-treatment-outcome
#20
Diane Reckziegel, Helen Bailey, William J Cottam, Christopher R Tench, Ravi P Mahajan, David A Walsh, Roger D Knaggs, Dorothee P Auer
INTRODUCTION: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current lack of understanding of mechanisms of chronic pain. Recently, duloxetine has demonstrated clinically relevant pain relief, but only in half of treated patients with OA. Here, the aim is to investigate the neural mechanisms of pain relief and neural signatures that may predict treatment response to duloxetine in chronic knee OA pain...
June 26, 2017: BMJ Open
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