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https://www.readbyqxmd.com/read/29146853/genome-sequences-of-four-subcluster-l2-mycobacterium-phages-finemlucis-miley16-wilder-and-zakai
#1
Christopher D Herren, Alexandra Peister, Timothy S Breton, Maggie S Hill, Marcy S Anderson, Adeline W Chang, Sydney B Klein, Mackenzie M Thornton, Stacy J Vars, Kasey E Wagner, Paige L Wiebe, Thomas G Williams, Coraima P Yanez, Jasanta M Ackles, Darius Artis, Ryan J Brazier, Ronald J Bryant, Kerel O Callwood, Isaiah H Carter, Cameron L DeBose, Christian D Edwards, Isaiah C Ezemba, Renshal R Joaquin, Zakai M Meghoo-Peddie, Ziha G Meghoo-Peddie, Ryan W Moore, Christopher E Smith, Adam J Turner, Raymond L Vorters, Jeffrey J Wider, Liesel L Krout, Mia S Comis, Madison J Davick, Eli E Michaud, Bailey E Shevenell, Sarah E Stanley, Chelsey I Frank, Jacob R Montgomery, Lawrence S Blumer, Jean A Doty, Martha Smith-Caldas, Welkin H Pope, Steven G Cresawn, Daniel A Russell, Rebecca A Garlena, Deborah Jacobs-Sera, Graham F Hatfull
Four subcluster L2 mycobacteriophages, Finemlucis, Miley16, Wilder, and Zakai, that infect Mycobacterium smegmatis mc(2)155 were isolated. The four phages are closely related to each other and code for 12 to 14 tRNAs and 130 to 132 putative protein-coding genes, including tyrosine integrases, cro, immunity repressors, and excise genes involved in the establishment of lysogeny.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29146117/implications-of-disturbances-in-circadian-rhythms-for-cardiovascular-health-a-new-frontier-in-free-radical-biology
#2
REVIEW
Neelam Khaper, Craig D C Bailey, Nilesh R Ghugre, Cristine Reitz, Zikra Awosanmi, Ryan Waines, Tami A Martino
Cell autonomous circadian "clock" mechanisms are present in virtually every organ, and generate daily rhythms that are important for normal physiology. This is especially relevant to the cardiovascular system, for example the circadian mechanism orchestrates rhythms in heart rate, blood pressure, cardiac contractility, metabolism, gene and protein abundance over the 24-hour day and night cycles. Conversely, disturbing circadian rhythms (e.g. via shift work, sleep disorders) increases cardiovascular disease risk, and exacerbates cardiac remodelling and worsens outcome...
November 13, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29144141/experimental-demonstration-of-a-sizeable-nonclassical-ch%C3%A2-%C3%A2-%C3%A2-g-hydrogen-bond-in-cyclohexane-derivatives-stabilization-of-an-axial-cyano-group
#3
Kyle M Lambert, Zachary D Stempel, Kenneth B Wiberg, William F Bailey
Base-catalyzed equilibration of anancomeric cyanocyclohexanes demonstrates that replacement of cis-3,5-dimethyl holding groups with electron-withdrawing CF3 groups dramatically increases the proportion of the axial cyano isomer present at equilibrium. The CF3 groups exert an effect on the conformational energy of the cyano group worth about 0.6 kcal/mol. A nonclassical hydrogen bond between the axial CN group and the syn-axial hydrogens is a major contributor to the axial stability of the group.
November 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29141885/a-role-for-bacterial-urease-in-gut-dysbiosis-and-crohn-s-disease
#4
Josephine Ni, Ting-Chin David Shen, Eric Z Chen, Kyle Bittinger, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S Friedman, Lillian Chau, Andrew Lin, Ilana Nissim, Justin Scott, Abigail Lauder, Christopher Hoffmann, Gloriany Rivas, Lindsey Albenberg, Robert N Baldassano, Jonathan Braun, Ramnik J Xavier, Clary B Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D Bushman, James D Lewis, Gary D Wu
Gut dysbiosis during inflammatory bowel disease involves alterations in the gut microbiota associated with inflammation of the host gut. We used a combination of shotgun metagenomic sequencing and metabolomics to analyze fecal samples from pediatric patients with Crohn's disease and found an association between disease severity, gut dysbiosis, and bacterial production of free amino acids. Nitrogen flux studies using (15)N in mice showed that activity of bacterial urease, an enzyme that releases ammonia by hydrolysis of host urea, led to the transfer of murine host-derived nitrogen to the gut microbiota where it was used for amino acid synthesis...
November 15, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29136597/lead-in-egyptian-soils-origin-reactivity-and-bioavailability-measured-by-stable-isotope-dilution
#5
W H Shetaya, E R Marzouk, E F Mohamed, M Elkassas, E H Bailey, S D Young
The current availability of Pb in Egyptian soils and associated plants were studied in 15 locations (n=159) that had been historically subjected to industrial and automobile Pb emissions. Isotopic dilution with enriched (204)Pb was used to estimate the soil Pb labile pool (PbE); results showed that %PbE values were mostly <25% which is likely due to the alkaline nature of the soils. Nonetheless, lability of Pb was significantly higher in urban and industrial locations indicating greater reactivity of anthropogenic Pb in comparison to geogenic-Pb...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29133803/microbial-diversity-of-genital-ulcers-of-hsv-2-seropositive-women
#6
Supriya D Mehta, Ashish K Pradhan, Stefan J Green, Ankur Naqib, Elijah Odoyo-June, Charlotte A Gaydos, Sheila Barry, Alan Landay, Robert C Bailey
We measured the microbial community structure of genital ulcers in women. Swabs from clinically detected ulcers were tested for HSV-2 and Treponema pallidum by polymerase chain reaction (PCR). HSV-2 and T. pallidum were detected by serum antibody testing. Microbial community structure was characterized by high-throughput 16 s rRNA gene amplicon sequencing. Multiple group testing and Elastic net and Lasso regressions identified taxa associated with differences in factors of interest. Among 49 ulcer specimens from 49 HSV-2 seropositive women, by PCR HSV-2 was recovered from 28 (57%) specimens and T...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29129182/integrated-one-stop-shop-youth-health-care-best-available-evidence-and-future-directions
#7
Sarah E Hetrick, Alan P Bailey, Kirsten E Smith, Ashok Malla, Steve Mathias, Swaran P Singh, Aileen O'Reilly, Swapna K Verma, Laelia Benoit, Theresa M Fleming, Marie Rose Moro, Debra J Rickwood, Joseph Duffy, Trissel Eriksen, Robert Illback, Caroline A Fisher, Patrick D McGorry
Although mental health problems represent the largest burden of disease in young people, access to mental health care has been poor for this group. Integrated youth health care services have been proposed as an innovative solution. Integrated care joins up physical health, mental health and social care services, ideally in one location, so that a young person receives holistic care in a coordinated way. It can be implemented in a range of ways. A review of the available literature identified a range of studies reporting the results of evaluation research into integrated care services...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29128708/childhood-brain-tumours-early-infections-and-immune-stimulation-a-pooled-analysis-of-the-escale-and-estelle-case-control-studies-sfce-france
#8
Judith E Lupatsch, Helen D Bailey, Brigitte Lacour, Christelle Dufour, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
BACKGROUND: Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. METHODS: We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies...
November 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29128490/responders-to-rtms-for-depression-show-increased-fronto-midline-theta-and-theta-connectivity-compared-to-non-responders
#9
N W Bailey, K E Hoy, N C Rogasch, R H Thomson, S McQueen, D Elliot, C M Sullivan, B D Fulcher, Z J Daskalakis, P B Fitzgerald
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression, but only some individuals respond. Predicting response could reduce patient and clinical burden. Neural activity related to working memory (WM) has been related to mood improvements, so may represent a biomarker for response prediction. PRIMARY HYPOTHESES: We expected higher theta and alpha activity in responders compared to non-responders to rTMS. METHODS: Fifty patients with treatment resistant depression and twenty controls performed a WM task while electroencephalography (EEG) was recorded...
October 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29127342/chemical-analysis-of-morphological-changes-in-lysophosphatidic-acid-treated-ovarian-cancer-cells
#10
Karen A Bailey, Yuliya Klymenko, Peter E Feist, Amanda B Hummon, M Sharon Stack, Zachary D Schultz
Ovarian cancer (OvCa) cells are reported to undergo biochemical changes at the cell surface in response to treatment with lysophosphatidic acid (LPA). Here we use scanning electron microscopy (SEM) and multiplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe morphological changes that result from LPA treatment. SEM images show distinct shedding of microvilli-like features upon treatment with LPA. Analysis of multiplex CARS images can distinguish between molecular components, such as lipids and proteins...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127253/first-biochemical-and-crystallographic-characterization-of-a-fast-performing-ferritin-from-a-marine-invertebrate
#11
E De Meulenaere, J B Bailey, F A Tezcan, D D Deheyn
Ferritin, a multimeric cage-like enzyme, is integral to iron metabolism across all phyla through the sequestration and storage of iron through efficient ferroxidase activity. While ferritin sequences from around 900 species have been identified, crystal structures from only 50 species have been reported, the majority from bacterial origin. We recently isolated a secreted ferritin from the marine invertebrate Chaetopterus sp. (parchment tubeworm), which resides in muddy coastal seafloors. Here, we present the first ferritin from a marine invertebrate to be crystallized, and its biochemical characterization...
November 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29122957/diminished-dynamic-cerebral-autoregulatory-capacity-with-forced-oscillations-in-mean-arterial-pressure-with-elevated-cardiorespiratory-fitness
#12
Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Samuel J E Lucas, Damian M Bailey, Jonathan D Smirl, Patrice Brassard
The effect that cardiorespiratory fitness has on the dynamic cerebral autoregulatory capacity during changes in mean arterial pressure (MAP) remains equivocal. Using a multiple-metrics approach, challenging MAP across the spectrum of physiological extremes (i.e., spontaneous through forced MAP oscillations), we characterized dynamic cerebral autoregulatory capacity in 19 male endurance athletes and eight controls via three methods: (1) onset of regulation (i.e., time delay before an increase in middle cerebral artery (MCA) conductance [MCA blood velocity (MCAv)/MAP] and rate of regulation, after transient hypotension induced by sit-to-stand, and transfer function analysis (TFA) of MAP and MCAv responses during (2) spontaneous and (3) forced oscillations (5-min of squat-stand maneuvers performed at 0...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29106697/navigational-efficiency-in-a-biased-and-correlated-random-walk-model-of-individual-animal-movement
#13
Joseph D Bailey, Jamie Wallis, Edward A Codling
Understanding how an individual animal is able to navigate through its environment is a key question in movement ecology that can give insight into observed movement patterns and the mechanisms behind them. Efficiency of navigation is important for behavioural processes at a range of different spatio-temporal scales, including foraging and migration. Random walk models provide a standard framework for modelling individual animal movement and navigation. Here we consider a vector-weighted biased and correlated random walk (BCRW) model for directed movement (taxis), where external navigation cues are balanced with forward persistence...
November 6, 2017: Ecology
https://www.readbyqxmd.com/read/29101959/pediatric-anesthesia-considerations-for-interventional-radiology
#14
REVIEW
Olivia Nelson, Philip D Bailey
Anesthesiologists are increasingly called on to care for pediatric patients undergoing diagnostic imaging and invasive procedures in interventional radiology. These procedures are typically classified as either nonvascular or vascular, and can range from short diagnostic imaging studies or biopsies to significantly longer and more invasive intravascular procedures. Anesthesia providers must consider each child's ability to cooperate reliably during the procedure, their age, and any cognitive impairment to define the best anesthetic plan...
December 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29093038/internet-gaming-disorder-in-children-and-adolescents
#15
REVIEW
Douglas A Gentile, Kira Bailey, Daphne Bavelier, Jeanne Funk Brockmyer, Hilarie Cash, Sarah M Coyne, Andrew Doan, Donald S Grant, C Shawn Green, Mark Griffiths, Tracy Markle, Nancy M Petry, Sara Prot, Cosette D Rae, Florian Rehbein, Michael Rich, Dave Sullivan, Elizabeth Woolley, Kimberly Young
The American Psychiatric Association recently included Internet gaming disorder (IGD) as a potential diagnosis, recommending that further study be conducted to help illuminate it more clearly. This paper is a summary of the review undertaken by the IGD Working Group as part of the 2015 National Academy of Sciences Sackler Colloquium on Digital Media and Developing Minds. By using measures based on or similar to the IGD definition, we found that prevalence rates range between ∼1% and 9%, depending on age, country, and other sample characteristics...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29093034/media-multitasking-and-cognitive-psychological-neural-and-learning-differences
#16
REVIEW
Melina R Uncapher, Lin Lin, Larry D Rosen, Heather L Kirkorian, Naomi S Baron, Kira Bailey, Joanne Cantor, David L Strayer, Thomas D Parsons, Anthony D Wagner
American youth spend more time with media than any other waking activity: an average of 7.5 hours per day, every day. On average, 29% of that time is spent juggling multiple media streams simultaneously (ie, media multitasking). This phenomenon is not limited to American youth but is paralleled across the globe. Given that a large number of media multitaskers (MMTs) are children and young adults whose brains are still developing, there is great urgency to understand the neurocognitive profiles of MMTs. It is critical to understand the relation between the relevant cognitive domains and underlying neural structure and function...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/29079946/depressive-symptoms-alcohol-and-drug-use-and-physical-and-sexual-abuse-among-men-who-have-sex-with-men-in-kisumu-kenya-the-anza-mapema-study
#17
Colin P Kunzweiler, Robert C Bailey, Duncan O Okall, Susan M Graham, Supriya D Mehta, Fredrick O Otieno
Men who have sex with men (MSM) are disproportionately burdened by depressive symptoms and psychosocial conditions including alcohol and substance abuse as well as physical and sexual abuse. We examined sociodemographic and psychosocial factors associated with depressive symptoms at baseline among a cohort of MSM in Kisumu, Kenya. Depressive symptoms were assessed via the Personal Health Questionnaire 9 instrument and examined dichotomously. We performed multivariable modified Poisson regression with robust standard errors for the binary outcome...
October 27, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29077470/erratum-sensitivity-of-d-p-reactions-to-high-n-p-momenta-and-the-consequences-for-nuclear-spectroscopy-studies-phys-rev-lett-117-162502-2016
#18
G W Bailey, N K Timofeyuk, J A Tostevin
This corrects the article DOI: 10.1103/PhysRevLett.117.162502.
October 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29075574/perinatal-western-type-diet-and-associated-gestational-weight-gain-alter-postpartum-maternal-mood
#19
Jessica L Bolton, Melanie G Wiley, Bailey Ryan, Samantha Truong, Melva Strait, Dana Creighton Baker, Nancy Y Yang, Olga Ilkayeva, Thomas M O'Connell, Shelley W Wroth, Cristina L Sánchez, Geeta Swamy, Christopher Newgard, Cynthia Kuhn, Staci D Bilbo, Leigh Ann Simmons
INTRODUCTION: The role of perinatal diet in postpartum maternal mood disorders, including depression and anxiety, remains unclear. We investigated whether perinatal consumption of a Western-type diet (high in fat and branched-chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A). METHODS: Mouse dams were fed one of four diets (high-fat/high BCAA, low-fat/high BCAA, high-fat, and low-fat) prior to mating and throughout gestation and lactation...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29071300/dopamine-d2-receptors-in-the-paraventricular-thalamus-attenuate-cocaine-locomotor-sensitization
#20
Abigail M Clark, Felix Leroy, Kelly M Martyniuk, Wendy Feng, Erika McManus, Matthew R Bailey, Jonathan A Javitch, Peter D Balsam, Christoph Kellendonk
Alterations in thalamic dopamine (DA) or DA D2 receptors (D2Rs) have been measured in drug addiction and schizophrenia, but the relevance of thalamic D2Rs for behavior is largely unknown. Using in situ hybridization and mice expressing green fluorescent protein (GFP) under the Drd2 promoter, we found that D2R expression within the thalamus is enriched in the paraventricular nucleus (PVT) as well as in more ventral midline thalamic nuclei. Within the PVT, D2Rs are inhibitory as their activation inhibits neuronal action potentials in brain slices...
September 2017: ENeuro
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