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https://www.readbyqxmd.com/read/29351716/effect-of-metformin-on-glycemic-control-in-patients-with-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#1
Haiyang Meng, Ailing Zhang, Yan Liang, Jie Hao, Xiaojian Zhang, Jingli Lu
BACKGROUND: For T1D patients, adding metformin to insulin therapies is thought to improve blood glucose levels, but current evidence does not support this clinical benefit. Additional data from large clinical trials are now available; therefore, we conducted a meta-analysis of studies on assessing the efficacy and adverse effects of metformin. METHODS: We searched the MEDLINE, EMBASE and Cochrane Library databases for data from randomized controlled trials (RCTs)...
January 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29351711/-beck-anxiety-inventory-german-version-a-reliable-valid-patientfriendly-instrument-for-measuring-clinical-anxiety
#2
Edgar Geissner, Anne Huetteroth
The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351710/-implementation-of-an-internet-based-self-help-for-patients-waiting-for-outpatient-psychotherapy-first-results
#3
Kristina Fuhr, Bettina Fahse, Martin Hautzinger, Marco Daniel Gulewitsch
INTRODUCTION: Numerous studies prove the efficacy of internet-based self-help programs, but integration into the health-care system was rarely investigated. The present study addresses the implementation of an internet-based self-help program into routine care of patients with depressive symptoms waiting for psychotherapy at the university outpatient center. MATERIAL AND METHODS: Patients waiting for outpatient psychotherapy were randomly assigned to either a control group or an intervention group that received access to the internet-based program Deprexis during the waiting period...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351692/homonymous-hemianopia-in-children-and-adolescents-an-mri-study
#4
Manja Haaga, Susanne Trauzettel-Klosinski, Anna Krumm, Stephan Küster, Iliya Ivanov, Angelika Cordey, Claudia Gehrlich, Martin Staudt
AIM:  Diagnosing homonymous hemianopia (HH) in children can be difficult due to inability to comply with perimetry. Therefore, HH can often only be suspected by magnetic resonance imaging (MRI) showing lesions to the retrochiasmatic visual pathways. The aim of our retrospective observational cross-sectional study was to improve the radiologic detection of HH. METHODS:  MRIs of 21 subjects (5-17 years old) with ophthalmologically confirmed HH (14 complete, 7 incomplete hemianopias) were analyzed...
January 19, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29351691/out-of-field-doses-in-children-treated-for-large-arteriovenous-malformations-using-hypofractionated-gamma-knife-radiosurgery-and-intensity-modulated-radiation-therapy
#5
Marijke De Saint-Hubert, Marija Majer, Hrvoje Hršak, Zdravko Heinrich, Željka Kneževic, Saveta Miljanic, Paulina Porwol, Liliana Stolarczyk, Filip Vanhavere, Roger M Harrison
The purpose of this study was to measure out-of-field organ doses in two anthropomorphic child phantoms for the treatment of large brain arteriovenous malformations (AVMs) using hypofractionated gamma knife (GK) radiosurgery and to compare these with an alternative treatment using intensity-modulated radiation therapy (IMRT). Target volume was identical in size and shape in all cases. Radiophotoluminescent (RPL), thermoluminescent (TL) and optically stimulated luminescent (OSL) dosimeters were used for out-of-field dosimetry during GK treatment and a good agreement within 1-2% between results was shown...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29351679/landmarks-for-identifying-the-suprascapular-foramen-anteriorly-application-to-anterior-neurotization-and-decompressive-procedures
#6
Olga V Manouvakhova, Veronica Macchi, Fabian N Fries, Marios Loukas, Raffaele De Caro, Rod J Oskouian, Robert J Spinner, R Shane Tubbs
BACKGROUND: Additional landmarks for identifying the suprascapular nerve at its entrance into the suprascapular foramen from an anterior approach would be useful to the surgeon. OBJECTIVE: To identify landmarks for the identification of this hidden site within an anterior approach. METHODS: In 8 adult cadavers (16 sides), lines were used to connect the superior angle of the scapula, the acromion, and the coracoid process tip thus creating an anatomic triangle...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29351668/evaluation-of-the-rapid-carbapenem-inactivation-method-rcim-a-phenotypic-screening-test-for-carbapenemase-producing-enterobacteriaceae
#7
Madalina-Maria Muntean, Andrei-Alexandru Muntean, Lauraine Gauthier, Elodie Creton, Garance Cotellon, Mircea Ioan Popa, Rémy A Bonnin, Thierry Naas
Objectives: Fast and accurate diagnostic tests to identify carbapenemase-producing Enterobacteriaceae (CPE) are mandatory for proper antimicrobial therapy and implementing infection control measures. Here, we have developed a rapid Carbapenem Inactivation Method (rCIM) for CPE detection. Methods: The rCIM consists of the incubation of a potential carbapenemase producer with meropenem discs and use of the resulting supernatant to challenge a susceptible indicator strain...
January 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29351662/the-versatile-tanycyte-a-hypothalamic-integrator-of-reproduction-and-energy-metabolism
#8
Vincent Prevot, Bénédicte Dehouck, Ariane Sharif, Philippe Ciofi, Paolo Giacobini, Jerome Clasadonte
The fertility and survival of an individual rely on the ability of the periphery to promptly, effectively and reproducibly communicate with brain neural networks that control reproduction, food intake and energy homeostasis. Tanycytes, a specialized glial cell type lining the wall of the third ventricle in the median eminence of the hypothalamus, appear to act as the linchpin of these processes by dynamically controlling the secretion of neuropeptides into the portal vasculature by hypothalamic neurons and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on the ability of these cells to adapt their morphology to the physiological state of the individual...
January 17, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29351654/what-is-the-role-of-imaging-in-the-clinical-diagnosis-of-osteoarthritis-and-disease-management
#9
Xia Wang, Win Min Oo, James M Linklater
While OA is predominantly diagnosed on the basis of clinical criteria, imaging may aid with differential diagnosis in clinically suspected cases. While plain radiographs are traditionally the first choice of imaging modality, MRI and US also have a valuable role in assessing multiple pathologic features of OA, although each has particular advantages and disadvantages. Although modern imaging modalities provide the capability to detect a wide range of osseous and soft tissue (cartilage, menisci, ligaments, synovitis, effusion) OA-related structural damage, this extra information has not yet favourably influenced the clinical decision-making and management process...
January 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29351646/effect-of-a-postpartum-training-program-on-prevalence-of-diastasis-recti-abdominis-in-postpartum-primiparous-women-a-randomized-controlled-trial
#10
Sandra L Gluppe, Gunvor Hilde, Merete K Tennfjord, Marie E Engh, Kari Bø
Background: Diastasis recti abdominis affects a significant number of women during the prenatal and postnatal period. Objective: The objective was to evaluate the effect of a postpartum training program on prevalence of diastasis recti abdominis. Design: The design was a secondary analysis of an assessor-masked randomized controlled trial. Methods: One hundred and seventy-five primiparous women (mean age 29.8±4.1) were randomized to an exercise or control group...
January 17, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29351639/call-to-action-prevention-of-mother-to-child-transmission-of-hepatitis-b-in-africa
#11
Peyton Wilson, Jonathan B Parr, Ravi Jhaveri, Steve R Meshnick
Hepatitis B virus (HBV) is a significant public health issue that has not been adequately addressed, especially in the high-prevalence region of Africa. Despite the incorporation of HBV vaccines into the Expanded Program on Immunization (EPI), children continue to be infected with HBV through maternal-to-child transmission (MTCT). The addition of a birth dose of HBV vaccine would be a cost-effective method to reduce MTCT. Birth-dose HBV vaccine policies have been adopted in the Western Pacific region but have yet to be implemented in the African region...
January 17, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29351632/presenteeism-in-academic-employees-occupational-and-individual-factors
#12
G Kinman, S Wray
Background: There is growing evidence that presenteeism can be damaging for individuals and organizations. It is, therefore, important to identify the prevalence of working while sick in different working environments and the factors that contribute to such behaviour. Aims: To examine the prevalence of self-reported presenteeism in academic staff working in UK universities and colleges and the extent to which job demands, control, support and work engagement are risk factors...
January 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29351626/neuroendovascular-fellowship-training-self-assessment-of-a-program-accredited-by-the-committee-on-advanced-subspecialty-training
#13
Hakeem J Shakir, Hussain Shallwani, Leonardo Rangel-Castilla, Amade Bregy, Jason M Davies, Ashish Sonig, Christopher S Ogilvy, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy
The University at Buffalo's neuroendovascular fellowship is one of the longest running fellowship programs in North America. The burgeoning neurointerventional workforce and the rapid growth in the neurointerventional space on the heels of groundbreaking clinical trials prompted us to assess the fellowship's academic impact and its graduates' perceptions and productivity. An anonymized web-based survey was sent to all former neuroendovascular fellows with specific questions pertaining to current practice, research and funding, and perceptions about the fellowship's impact on their skills, competitiveness, and compensation...
January 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29351615/18f-fluorodeoxyglucose-positron-emission-computed-tomography-and-computed-tomography-angiography-in-prosthetic-heart-valve-endocarditis-from-guidelines-to-clinical-practice
#14
Laurens E Swart, Asbjørn M Scholtens, Wilco Tanis, Koen Nieman, Ad J J C Bogers, Fred J Verzijlbergen, Gabriel P Krestin, Jolien W Roos-Hesselink, Ricardo P J Budde
The timely diagnosis of prosthetic heart valve endocarditis remains challenging yet of utmost importance. 18F-fluorodeoxyglucose (18 F-FDG) positron emission/computed tomography (PET/CT) and cardiac computed tomography angiography (CTA) were recently introduced as additional diagnostic tools in the most recent ESC guidelines on infective endocarditis. However, how to interpret PET/CT findings with regard to what is to be considered abnormal, what the potential confounders may be, as well as which patients benefit most from these additional imaging techniques and how to best perform them in these often-complex patients, remains unclear...
January 16, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29351603/the-unexpected-function-of-a-flavin-dependent-oxidoreductase-fox-from-variovorax-paradoxus-tbea6
#15
Christina Meinert, Marc Schürmann, Jan-Eike Domeyer, Anja Poehlein, Rolf Daniel, Alexander Steinbüchel
3,3'-Thiodipropionic acid (TDP) is used as an additive in food and cosmetic industry and as precursor substrate for biotechnical polythioester production. Its catabolism was investigated in Variovorax paradoxus TBEA6 previous to this study. It was reported that the insertion of the transposon Tn5::mob into a gene showing high homology to flavin-dependent oxidoreductases (fox) resulted in impaired growth with TDP. Therefore, it was assumed that the initial cleavage of TDP is catalyzed by an FAD-dependent oxidoreductase (Fox, VPARA_05580)...
January 17, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29351594/sero-efficacy-of-vi-polysaccharide-tetanus-toxoid-typhoid-conjugate-vaccine-typbar-tcv
#16
Merryn Voysey, Andrew J Pollard
Background: Salmonella Typhi is the major cause of enteric fever in lower income countries. New conjugate vaccines show promise as public health interventions, however there are no efficacy data available from endemic areas. Methods: Data were obtained from a previously published phase 3 randomised controlled trial comparing Vi-polysaccharide tetanus-toxoid conjugate vaccine (Typbar-TCV; Bharat Biotech Intl Ltd, India): (Vi-TT) with Vi-polysaccharide (Typbar; Bharat Biotech Intl Ltd, India): (Vi-PS) in participants aged 2- 45 years...
January 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29351582/sco2-mutations-cause-early-onset-axonal-charcot-marie-tooth-disease-associated-with-cellular-copper-deficiency
#17
Adriana P Rebelo, Dimah Saade, Claudia P Pereira, Amjad Farooq, Tyler C Huff, Lisa Abreu, Carlos T Moraes, Diana Mnatsakanova, Kathy Mathews, Hua Yang, Eric A Schon, Stephan Zuchner, Michael E Shy
Recessive mutations in the mitochondrial copper-binding protein SCO2, cytochrome c oxidase (COX) assembly protein, have been reported in several cases with fatal infantile cardioencephalomyopathy with COX deficiency. Significantly expanding the known phenotypic spectrum, we identified compound heterozygous variants in SCO2 in two unrelated patients with axonal polyneuropathy, also known as Charcot-Marie-Tooth disease type 4. Different from previously described cases, our patients developed predominantly motor neuropathy, they survived infancy, and they have not yet developed the cardiomyopathy that causes death in early infancy in reported patients...
January 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29351557/effects-of-night-time-and-weekend-admissions-on-in-hospital-mortality-in-acute-myocardial-infarction-patients-in-japan
#18
Seiko Mizuno, Susumu Kunisawa, Noriko Sasaki, Kiyohide Fushimi, Yuichi Imanaka
BACKGROUND: Patients admitted to hospital during off-hours may experience poorer quality of care and clinical outcomes. However, few studies have examined the variations in clinical processes and outcomes across admission times and days of the week in acute myocardial infarction (AMI) patients. This study aimed to comparatively analyze the effect of weekend and weekday admissions stratified by admission time on in-hospital mortality in AMI patients. METHODS AND RESULTS: Using a large nationwide administrative database, we analyzed 103,908 AMI patients admitted to 639 Japanese acute care hospitals between April 2011 and March 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29351465/emerging-potential-benefits-of-modulating-nad-metabolism-in-cardiovascular-disease
#19
Daniel S Matasic, Charles Brenner, Barry London
Nicotinamide adenine dinucleotide (NAD+) and related metabolites are central mediators of fuel oxidation and bioenergetics within cardiomyocytes. Additionally, NAD+ is required for the activity of multifunctional enzymes including sirtuins and poly(ADP-ribose) polymerases (PARPs) that regulate post-translational modifications, DNA damage responses, and calcium signaling. Recent research indicates that NAD+ participates in a multitude of processes dysregulated in cardiovascular diseases. Therefore, supplementation of NAD+ precursors including nicotinamide riboside (NR) that boost or replete the NAD+ metabolome may be cardioprotective...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351464/vitamin-d-and-regulation-of-vascular-cell-function
#20
Nasim Jamali, Christine M Sorenson, Nader Sheibani
Vitamin D deficiency is linked to pathogenesis of many diseases including cardiovascular, cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation of immune function, inflammation, angiogenesis, and aging have been demonstrated. Thus, vitamin D and its analogs have been evaluated for treatment of various types of cancer and chronic diseases. We previously showed that the active form of vitamin D (1, 25(OH)2D3) is a potent inhibitor of angiogenesis. This activity is consistent with the important role proposed for vitamin D and its analogs in the mitigation of tumor growth through inhibition of angiogenesis...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
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