keyword
MENU ▼
Read by QxMD icon Read
search

Cfs/me

keyword
https://www.readbyqxmd.com/read/27920164/epistemic-injustice-in-healthcare-encounters-evidence-from-chronic-fatigue-syndrome
#1
Charlotte Blease, Havi Carel, Keith Geraghty
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) remains a controversial illness category. This paper surveys the state of knowledge and attitudes about this illness and proposes that epistemic concerns about the testimonial credibility of patients can be articulated using Miranda Fricker's concept of epistemic injustice. While there is consensus within mainstream medical guidelines that there is no known cause of CFS/ME, there is continued debate about how best to conceive of CFS/ME, including disagreement about how to interpret clinical studies of treatments...
December 5, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27842587/experiences-of-general-practitioner-continuity-among-women-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-cross-sectional-study
#2
Anne Helen Hansen, Olaug S Lian
BACKGROUND: Continuity of care is important for patients with chronic illness in need of coordinated healthcare services from multiple providers. Little is known about how patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) experience continuity of GP care. This study explores how women with CFS/ME experience GP care across the three dimensions of continuity: informational, management, and relational continuity. METHODS: This cross-sectional study uses questionnaire data collected from members of The Norwegian ME Association...
November 14, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27835969/a-targeted-genome-association-study-examining-transient-receptor-potential-ion-channels-acetylcholine-receptors-and-adrenergic-receptors-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#3
Samantha Johnston, Donald Staines, Anne Klein, Sonya Marshall-Gradisnik
BACKGROUND: Chronic Fatigue Syndrome, also known as Myalgic Encephalomyelitis (CFS/ME) is a debilitating condition of unknown aetiology. It is characterized by a range of physiological effects including neurological, sensory and motor disturbances. This study examined candidate genes for the above clinical manifestations to identify single nucleotide polymorphism (SNP) alleles associated with CFS/ME compared with healthy controls. METHODS: DNA was extracted and whole genome genotyping was performed using the HumanOmniExpress BeadChip array...
November 11, 2016: BMC Medical Genetics
https://www.readbyqxmd.com/read/27834303/single-nucleotide-polymorphisms-and-genotypes-of-transient-receptor-potential-ion-channel-and-acetylcholine-receptor-genes-from-isolated-b-lymphocytes-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-patients
#4
Sonya Marshall-Gradisnik, Samantha Johnston, Anu Chacko, Thao Nguyen, Peter Smith, Donald Staines
OBJECTIVE: The pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is unknown; however, a small subgroup of patients has shown muscarinic antibody positivity and reduced symptom presentation following anti-CD20 intervention. Given the important roles of calcium (Ca(2+)) and acetylcholine (ACh) signalling in B cell activation and potential antibody development, we aimed to identify relevant single nucleotide polymorphisms (SNPs) and genotypes in isolated B cells from CFS/ME patients...
November 10, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27808584/support-for-the-microgenderome-invites-enquiry-into-sex-differences
#5
Amy Wallis, Henry Butt, Michelle Ball, Donald P Lewis, Dorothy Bruck
The microgenderome defines the interaction between microbiota, sex hormones and the immune system. Our recent research inferred support for the microgenderome by showing sex differences in microbiota-symptom associations in a clinical sample of patients with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). This addendum expands upon the sex-specific pattern of associations that were observed. Interpretations are hypothesized in relation to genera versus species-level analyses and D-lactate theory...
November 3, 2016: Gut Microbes
https://www.readbyqxmd.com/read/27806082/metagenomic-investigation-of-plasma-in-individuals-with-me-cfs-highlights-the-importance-of-technical-controls-to-elucidate-contamination-and-batch-effects
#6
Ruth R Miller, Miguel Uyaguari-Diaz, Mark N McCabe, Vincent Montoya, Jennifer L Gardy, Shoshana Parker, Theodore Steiner, William Hsiao, Matthew J Nesbitt, Patrick Tang, David M Patrick
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease causing indefinite fatigue. ME/CFS has long been hypothesised to have an infectious cause; however, no specific infectious agent has been identified. We used metagenomics to analyse the RNA from plasma samples from 25 individuals with ME/CFS and compare their microbial content to technical controls as well as three control groups: individuals with alternatively diagnosed chronic Lyme syndrome (N = 13), systemic lupus erythematosus (N = 11), and healthy controls (N = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27766535/hypothalamic-pituitary-adrenal-hypofunction-in-myalgic-encephalomyelitis-me-chronic-fatigue-syndrome-cfs-as-a-consequence-of-activated-immune-inflammatory-and-oxidative-and-nitrosative-pathways
#7
Gerwyn Morris, George Anderson, Michael Maes
There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS) pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS). There is also evidence that these neuroimmune diseases are accompanied by hypothalamic-pituitary-adrenal (HPA) axis hypoactivity as indicated by lowered baseline glucocorticoid levels. This paper aims to review the bidirectional communications between immune-inflammatory and O&NS pathways and HPA axis hypoactivity in ME/CFS, considering two possibilities: (a) Activation of immune-inflammatory pathways is secondary to HPA axis hypofunction via attenuated negative feedback mechanisms, or (b) chronic activated immune-inflammatory and O&NS pathways play a causative role in HPA axis hypoactivity...
October 20, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27742756/-it-s-personal-to-me-a-qualitative-study-of-depression-in-young-people-with-cfs-me
#8
Anna K Taylor, Maria Loades, Amberly Lc Brigden, Simon M Collin, Esther Crawley
BACKGROUND: Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has a prevalence of 0.4-2.4% and is defined as 'generalised disabling fatigue persisting after routine tests and investigations have failed to identify an obvious underlying cause'. One-third of young people with CFS/ME have probable depression. Little is known about why depression develops, the relationship between depression and CFS/ME, or what treatment might be helpful. METHODS: We conducted nine semi-structured interviews with young people with CFS/ME (aged 13-17 years, 8/9 female) and probable depression, covering perceived causes of depression, the relationship between CFS/ME and depression, and treatment strategies...
October 14, 2016: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/27737819/-i-always-vet-things-navigating-privacy-and-the-presentation-of-self-on-health-discussion-boards-among-individuals-with-long-term-conditions
#9
Ellen Brady, Julia Segar, Caroline Sanders
BACKGROUND: The ethics of research into online communities is a long-debated issue, with many researchers arguing that open-access discussion groups are publically accessible data and do not require informed consent from participants for their use for research purposes. However, it has been suggested that there is a discrepancy between the perceived and actual privacy of user-generated online content by community members. OBJECTIVE: There has been very little research regarding how privacy is experienced and enacted online...
October 13, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27729349/treatment-for-paediatric-chronic-fatigue-syndrome-or-myalgic-encephalomyelitis-cfs-me-and-comorbid-depression-a-systematic-review
#10
Maria E Loades, Elizabeth A Sheils, Esther Crawley
OBJECTIVES: At least 30% of young people with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) also have symptoms of depression. This systematic review aimed to establish which treatment approaches for depression are effective and whether comorbid depression mediates outcome. SETTING: A systematic review was undertaken. The search terms were entered into MEDLINE, EMBASE, PsycInfo and the Cochrane library. PARTICIPANTS: Inclusion and exclusion criteria were applied to identify relevant papers...
October 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27727448/impaired-calcium-mobilization-in-natural-killer-cells-from-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients-is-associated-with-transient-receptor-potential-melastatin-3-ion-channels
#11
T Nguyen, S Johnston, L Clarke, P Smith, D Staines, S Marshall-Gradisnik
Transient receptor potential melastatin subfamily 3 (TRPM3) ion channels play a role in calcium (Ca(2+) ) cell signalling. Reduced TRPM3 protein expression has been identified in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) patients. However, the significance of TRPM3 and association with intracellular Ca(2+) mobilization has yet to be determined. Fifteen CFS/ME patients (mean age 48·82 ± 9·83 years) and 25 healthy controls (mean age 39·2 ± 12·12 years) were examined. Isolated natural killer (NK) cells were labelled with fluorescent antibodies to determine TRPM3, CD107a and CD69 receptors on CD56(dim) CD16(+) NK cells and CD56(bright) CD16(dim/-) NK cells...
October 11, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27721367/a-pair-of-identical-twins-discordant-for-myalgic-encephalomyelitis-chronic-fatigue-syndrome-differ-in-physiological-parameters-and-gut-microbiome-composition
#12
Ludovic Giloteaux, Maureen R Hanson, Betsy A Keller
BACKGROUND Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present with profound fatigue, flu-like symptoms, pain, cognitive impairment, orthostatic intolerance, and post-exertional malaise (PEM), and exacerbation of some or all of the baseline symptoms. CASE REPORT We report on a pair of 34-year-old monozygotic twins discordant for ME/CFS, with WELL, the non-affected twin, and ILL, the affected twin. Both twins performed a two-day cardiopulmonary exercise test (CPET), pre- and post-exercise blood samples were drawn, and both provided stool samples for biochemical and molecular analysis...
October 10, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27600520/the-utility-of-patient-reported-outcome-measures-among-patients-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#13
Kyle W Murdock, Xin Shelley Wang, Qiuling Shi, Charles S Cleeland, Christopher P Fagundes, Suzanne D Vernon
PURPOSE: Debilitating fatigue is a core symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, the utility of patient-reported symptom outcome measures of fatigue for ME/CFS patients is problematic due to ceiling effects and issues with reliability and validity. We sought to evaluate the performance of three patient-reported symptom measures in a sample of ME/CFS patients and matched controls. METHODS: Two hundred and forty ME/CFS patients and 88 age, sex, race, and zip code matched controls participated in the study...
September 6, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27594784/dysregulation-of-protein-kinase-gene-expression-in-nk-cells-from-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients
#14
Anu Chacko, Donald R Staines, Samantha C Johnston, Sonya M Marshall-Gradisnik
BACKGROUND: The etiology and pathomechanism of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are unknown. However, natural killer (NK) cell dysfunction, in particular reduced NK cytotoxic activity, is a consistent finding in CFS/ME patients. Previous research has reported significant changes in intracellular mitogen-activated protein kinase pathways from isolated NK cells. The purpose of this present investigation was to examine whether protein kinase genes have a role in abnormal NK cell intracellular signaling in CFS/ME...
2016: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/27590471/comorbidities-treated-in-primary-care-in-children-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-nationwide-registry-linkage-study-from-norway
#15
Inger J Bakken, Kari Tveito, Kari M Aaberg, Sara Ghaderi, Nina Gunnes, Lill Trogstad, Per Magnus, Camilla Stoltenberg, Siri E Håberg
BACKGROUND: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex condition. Causal factors are not established, although underlying psychological or immunological susceptibility has been proposed. We studied primary care diagnoses for children with CFS/ME, with children with another hospital diagnosis (type 1 diabetes mellitus [T1DM]) and the general child population as comparison groups. METHODS: All Norwegian children born 1992-2012 constituted the study sample...
2016: BMC Family Practice
https://www.readbyqxmd.com/read/27580693/association-of-biomarkers-with-health-related-quality-of-life-and-history-of-stressors-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-patients
#16
Emmanuel Fenouillet, Aude Vigouroux, Jean Guillaume Steinberg, Alexandre Chagvardieff, Frédérique Retornaz, Regis Guieu, Yves Jammes
BACKGROUND: Myalgic encephalomyelitis chronic fatigue syndrome (ME/CFS) is a common debilitating disorder associated with an intense fatigue, a reduced physical activity, and an impaired quality of life. There are no established biological markerof the syndrome. The etiology is unknown and its pathogenesis appears to be multifactorial. Various stressors, including intense physical activity, severe infection, and emotional stress are reported in the medical history of ME/CFS patients which raises the question whether any physiological and biological abnormalities usually found in these patients could be indicative of the etiology and/or the quality-of-life impairment...
August 31, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27573827/metabolic-features-of-chronic-fatigue-syndrome
#17
Robert K Naviaux, Jane C Naviaux, Kefeng Li, A Taylor Bright, William A Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon
More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using these methods. Forty-five subjects (n = 22 men and 23 women) met diagnostic criteria for ME/CFS by Institute of Medicine, Canadian, and Fukuda criteria. Thirty-nine subjects (n = 18 men and 21 women) were age- and sex-matched normal controls. Males with CFS were 53 (±2...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27536947/serum-baff-and-april-levels-t-lymphocyte-subsets-and-immunoglobulins-after-b-cell-depletion-using-the-monoclonal-anti-cd20-antibody-rituximab-in-myalgic-encephalopathy-chronic-fatigue-syndrome
#18
Sigrid Lunde, Einar K Kristoffersen, Dipak Sapkota, Kristin Risa, Olav Dahl, Ove Bruland, Olav Mella, Øystein Fluge
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is a disease of unknown etiology. We have previously suggested clinical benefit from B-cell depletion using the monoclonal anti-CD20 antibody rituximab in a randomized and placebo-controlled study. Prolonged responses were then demonstrated in an open-label phase-II study with maintenance rituximab treatment. Using blood samples from patients in the previous two clinical trials, we investigated quantitative changes in T-lymphocyte subsets, in immunoglobulins, and in serum levels of two B-cell regulating cytokines during follow-up...
2016: PloS One
https://www.readbyqxmd.com/read/27521652/enhanced-psychological-flexibility-and-improved-quality-of-life-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#19
Sarah Densham, Deborah Williams, Anne Johnson, Julie M Turner-Cobb
OBJECTIVE: Psychological Flexibility (PF) is a relatively new concept in physical health. It can be defined as an overarching process of being able to accept the presence of wanted/unwanted experiences, choosing whether to change or persist in behaviour in response to those experiences. Associations between processes of PF and quality of life (QoL) have been found in long-term health conditions such as chronic pain, PF has not yet been applied to Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)...
September 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27436349/investigating-unexplained-fatigue-in-general-practice-with-a-particular-focus-on-cfs-me
#20
Amolak S Bansal
Unexplained fatigue is not infrequent in the community. It presents a number of challenges to the primary care physician and particularly if the clinical examination and routine investigations are normal. However, while fatigue is a feature of many common illnesses, it is the main problem in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). This is a poorly understood condition that is accompanied by several additional symptoms which suggest a subtle multisystem dysfunction. Not infrequently it is complicated by sleep disturbance and alterations in attention, memory and mood...
2016: BMC Family Practice
keyword
keyword
80147
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"