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https://www.readbyqxmd.com/read/28921726/chlamydia-trachomatis-regulates-innate-immune-barrier-integrity-and-mediates-cytokine-and-antimicrobial-responses-in-human-uterine-ecc-1-epithelial-cells
#1
Lucy Rudo Mukura, Danica K Hickey, Marta Rodriguez-Garcia, John V Fahey, Charles R Wira
PROBLEM: Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection worldwide and known to increase the risk for HIV acquisition. Few studies have investigated how infection of epithelial cells compromises barrier integrity and antimicrobial response. METHOD OF STUDY: ECC-1 cells, a human uterine epithelial cell line, were treated with live and heat-killed C. trachomatis. Epithelial barrier integrity measured as transepithelial resistance (TER), chemokines antimicrobial levels, and antimicrobial mRNA expression was measured by ELISA and Real-time RT-PCR...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28920768/sexually-transmitted-infections-compelling-case-for-an-improved-screening-strategy
#2
Stephen Hull, Seán Kelley, Janice L Clarke
Sexually Transmitted Infections: Compelling Case for an Improved Screening Strategy Stephen Hull, MHS, Seán Kelley, MD, MSc, and Janice L. Clarke, RN, BBA Editorial: Sexually Transmitted Infections-A Fixable Problem: David B. Nash, MD, MBA   S-3 Introduction   S-3 Rising Prevalence of Sexually Transmitted Diseases (STIs)   S-4 Current Screening Rates for Chlamydia and Gonorrhea   S-4 The Human Toll and Economic Burden of STI-Related Illness   S-5 Current Screening Guidelines for Chlamydia and Gonorrhea   S-5 Factors Contributing to Inadequate Screening, Diagnosis, and Treatment for STIs   S-6 Methods Used to Improve Screening Rates   S-7 Benefits of Opt-Out Screening Strategies for STIs   S-8 Cost-Effectiveness of Screening for STIs   S-8 Discussion   S-9 Conclusion   S-10...
September 2017: Population Health Management
https://www.readbyqxmd.com/read/28919833/conventional-culture-versus-nucleic-acid-amplification-tests-for-screening-of-urethral-neisseria-gonorrhea-infection-among-asymptomatic-men-who-have-sex-with-men
#3
Jiratha Budkaew, Bandit Chumworathayi, Chamsai Pientong, Tipaya Ekalaksananan
BACKGROUND: Many methods are used to detect urethral Neisseria gonorrhea (NG) infection among asymptomatic men who have sex with men (MSM). The objective of this study was to define the performance of conventional culture compared to real-time polymerase chain reaction (PCR) for diagnosis of asymptomatic urethral gonorrhea among MSM. METHODS: In this cross-sectional study, 147 clinical specimens for NG testing from asymptomatic participants were evaluated. MSM >18 years old who consented to undergo urethral swab and collection of urine samples from two clinics (one was the sexually transmitted diseases (STDs) mobile clinic and the second was the antiretroviral clinic) located in Khon Kaen, Thailand, were recruited...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28919017/molecular-characterization-of-lower-vaginal-swabs-for-human-papilloma-virus-in-association-with-chlamydia-trachomatis-infection-in-cameroonian-women
#4
Pythagore Fogue, Geraldo Djeudong, George Bouting, Elom Aglago, Gustave Simo, Smiths Lueong
Human papilloma virus (HPV) infection is an etiological factor for cervical cancer development and Chlamydia trachomatis (Ct) is considered as a cofactor. Understanding the dynamics of HPV and Ct infection could help to explain the incidence of early onset of cervical cancer (CC) observed in Cameroon. Lower vaginal swabs and sera from sexually active women were analyzed for HPV and Ct infection in association with risk factors. Questionnaires were used to document patients' lifestyle and risk factors. A total of 206 women participated in the study average 28...
September 14, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28918994/meaningful-methods-for-increasing-human-papillomavirus-vaccination-rates-an%C3%A2-integrative-literature-review
#5
Kristin Vollrath, Susan Thul, Jenny Holcombe
Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and is a well-known cause of oropharyngeal, cervical, vaginal, vulvar, penile, and anal cancers. Despite the proven efficacy of the HPV vaccine, vaccination rates remain persistently low. Much literature has focused on attitudes toward the HPV vaccine; however, researchers have also investigated strategies clinicians can use to improve vaccination attitudes and acceptance. Such strategies include provider education, vaccine reminder/recall, and chart audit and feedback...
September 14, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/28918600/morphology-and-size-of-blood-cells-of-rhinella-arenarum-hensel-1867-as-environmental-health-assessment-in-disturbed-aquatic-ecosystem-from-central-argentina
#6
Zulma Anahí Salinas, Mariana Baraquet, Pablo Raúl Grenat, Adolfo Ludovico Martino, Nancy Edith Salas
Four populations of Rhinella arenarum from aquatic environments with different degrees of disturbance in central Argentina were compared to assess the ability of cytomorphology and cytomorphometry of blood cells as a hematological biomarker. A total of 93 specimens of R. arenarum (adults sexually mature) were captured during the spring. From the analysis of cell, no variations were found in terms of morphology, whereas in nuclear and cell areas and Price-Jones curves, we observed a smaller size in erythrocytes of individuals inhabiting the site most altered, "Villa Dalcar," as well as for leukocytes, lymphocytes, neutrophils, and eosinophils for the same site...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28916285/profiling-of-bisphenol-s-towards-nuclear-receptors-activities-in-human-reporter-cell-lines
#7
Ondrej Zenata, Zdenek Dvorak, Radim Vrzal
Bisphenol S (BPS) is heat-stable structural analog of bisphenol A (BPA), a known endocrine disruptor. Due to the effort to replace BPA with BPS, it is essential to know if BPS is suitable non-toxic replacement without reported deleterious effects of BPA. Since most of the BPA effects are ascribed to its ability to activate nuclear receptors, we screened some prominent members of this family in order to confirm or refute some recent findings. We found that BPS insignificantly activated aryl hydrocarbon receptor (AhR) in reporter gene assay and no induction of AhR target gene CYP1A1 was observed in human hepatocytes (HH)...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28914121/evidence-based-recommendations-to-improve-reproductive-healthcare-for-incarcerated-women
#8
Andrea Knittel, Angeline Ti, Sarah Schear, Megan Comfort
Purpose The purpose of this paper is to describe standards for evidence-based reproductive healthcare for incarcerated women. Design/methodology/approach The literature on reproductive healthcare in the US criminal justice system and recommendations from professional organizations were reviewed and critical areas of concern were identified. Within these areas, studies and expert opinion were synthesized and policy recommendations were formulated through an iterative process of group discussion and document revision...
September 11, 2017: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/28913693/human-papillomavirus-genotype-distribution-in-cervical-samples-among-vaccine-na%C3%A3-ve-barbados-women
#9
Juann M Ward, Kolin Schmalenberg, Nick A Antonishyn, Ian R Hambleton, Elizabeth L Blackman, Paul N Levett, Marquita V Gittens-St Hilaire
PURPOSE: This study was undertaken to provide baseline HPV genotype distribution among women in Barbados before HPV immunization was introduced. This information would then be used as a denominator for post-vaccine surveillance and is expected to aid in understanding the effect of vaccination on cervical disease in Barbados. METHODS: Liquid-based cytology specimens were collected from 413 women (age range 18-65 years) attending three clinics, in a pre-vaccination, population-based study...
September 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28913332/the-impact-of-disclosure-on-health-and-related-outcomes-in-human-immunodeficiency-virus-infected-children-a-literature-review
#10
REVIEW
Angela Odiachi
This review explores the association between pediatric human immunodeficiency virus (HIV) disclosure and health and related outcomes among children living with HIV. A multi-stage process was used to search for relevant articles on the ISI Web of Knowledge database. Fifteen articles met the inclusion criteria. Five major outcomes emerged from children's knowledge of their HIV-seropositive status: physical/physiological outcomes; adherence to antiretroviral therapy; psychosocial outcomes; sexual and reproductive health, including HIV prevention outcomes; and disclosure of status by the children...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28912340/donor-recipient-identification-in-para-and-poly-phyletic-trees-under-alternative-hiv-1-transmission-hypotheses-using-approximate-bayesian-computation
#11
Ethan O Romero-Severson, Ingo Bulla, Nick Hengartner, Inês Bártolo, Ana Abecasis, José M Azevedo-Pereira, Nuno Taveira, Thomas Leitner
Diversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections there is clear evidence for multiple founding variants, which can influence the efficacy of putative prevention methods and the reconstruction of epidemiologic histories. To infer who-infected-whom and to compute the probability of alternative transmission scenarios, while explicitly taking phylogenetic uncertainty into account, we created an Approximate Bayesian Computation (ABC) method based on a set of statistics measuring phylogenetic topology, branch lengths, and genetic diversity...
September 14, 2017: Genetics
https://www.readbyqxmd.com/read/28912031/hormones-and-the-coolidge-effect
#12
REVIEW
Elisa Ventura-Aquino, Alonso Fernández-Guasti, Raúl G Paredes
The Coolidge effect is the renewal of sexual behavior after the presentation of a novel sexual partner and possibly occurs as the result of habituation and dishabituation processes. This re-motivation to copulate is well studied in males and is commonly related to sexual satiety, which involves several neurobiological changes in steroid receptors and their mRNA expression in the CNS. On the other hand, there are few reports studying sexual novelty in females and have been limited to behavioral aspects. Here we report that the levels of rat proceptive behavior, a sign of sexual motivation, declines after 4 h of continuous mating, particularly in females that were unable to regulate the time of mating...
September 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28911201/gene-expression-profiling-of-puberty-associated-genes-reveals-abundant-tissue-and-sex-specific-changes-across-postnatal-development
#13
Huayun Hou, Liis Uusküla-Reimand, Maisam Makarem, Christina Corre, Shems Saleh, Ariane Metcalf, Anna Goldenberg, Mark R Palmert, And Michael D Wilson
The timing of human puberty is highly variable, sexually dimorphic, and associated with adverse health outcomes. Over 20 genes carrying rare mutations have been identified in known pubertal disorders, many of which encode critical components of the hypothalamic-pituitary-gonadal (HPG) axis. Recent genome-wide association studies (GWAS) have identified more than 100 candidate genes at loci associated with age at menarche or voice breaking in males. We know little about the spatial, temporal or postnatal expression patterns of the majority of these puberty-associated genes...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28910359/prevalence-and-determinants-of-oral-infection-by-human-papillomavirus-in-hiv-infected-and-uninfected-men-who-have-sex-with-men
#14
Francesca Rollo, Alessandra Latini, Barbara Pichi, Manuela Colafigli, Maria Benevolo, Ilenia Sinopoli, Isabella Sperduti, Valentina Laquintana, Giulia Fabbri, Mirko Frasca, Antonio Cristaudo, Massimo Giuliani, Maria Gabriella Donà
BACKGROUND: Oral Human Papillomavirus (HPV) infection is rare in the general population but common in high-risk individuals. Recent data indicate that oral HPV is associated with the development of head and neck carcinomas. HPV16 infection, in particular, increases the risk of oropharyngeal cancer. METHODS: We evaluated oral HPV prevalence and determinants of infection in cancer-free HIV-infected and uninfected men who have sex with men (MSM) recruited among attendees of an STI/HIV centre...
2017: PloS One
https://www.readbyqxmd.com/read/28906006/prevalence-of-anal-oral-penile-and-urethral-human-papillomavirus-in-hiv-infected-and-hiv-uninfected-men-who-have-sex-with-men
#15
Claudio Ucciferri, Manuela Tamburro, Katia Falasca, Michela Lucia Sammarco, Giancarlo Ripabelli, Jacopo Vecchiet
Aims of the study were to evaluate Human Papillomavirus (HPV) and type-specific prevalence in four anatomical sites in HIV infected men who have sex with men (MSM) compared with HIV uninfected MSM. Participants were recruited among the attendees of Infectious Diseases Clinics in Central Italy. A trained medical practitioner collected by interview sociodemographic data and information on medical history, sexual behavior and drug use. Swabs from anal canal, oral cavity, urethral mucosa and coronal sulcus were tested for HPV DNA and genotyping...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28905453/sexual-steroids-in-serum-and-prostatic-tissue-of-human-non-cancerous-prostate-sterproser-trial
#16
Yann Neuzillet, Jean-Pierre Raynaud, Camélia Radulescu, Jean Fiet, Franck Giton, Jean-François Dreyfus, Tarek P Ghoneim, Thierry Lebret, Henry Botto
BACKGROUND: The specific involvement of the sex steroids in the growth of the prostatic tissue remains unclear. Sex steroid concentrations in plasma and in fresh surgical samples of benign central prostate were correlated to prostate volume. METHODS: Monocentric prospective study performed between September 2014 and January 2017. Age, obesity parameters, and both serum and intraprostatic concentrations of sex steroids were collected complying with the latest Endocrine Society guidelines and the steroids assessed by GC/MS...
September 14, 2017: Prostate
https://www.readbyqxmd.com/read/28905269/differences-in-neural-response-to-romantic-stimuli-in-monogamous-and-non-monogamous-men
#17
Lisa Dawn Hamilton, Cindy M Meston
In non-human animal research, studies comparing socially monogamous and promiscuous species of voles (Microtus) have identified some key neural differences related to monogamy and non-monogamy. Specifically, densities of the vasopressin V1a receptor and dopamine D2 receptors in subcortical reward-related and limbic areas of the brain have been linked to monogamous behavior in prairie voles (Microtus ochrogaster). Similar brain areas have been shown to be correlated with feelings of romantic love in monogamously pair-bonded humans...
September 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28904953/nonpaternity-and-half-siblingships-as-objective-measures-of-extramarital-sex-mathematical-modeling-and-simulations
#18
Ryosuke Omori, Nico Nagelkerke, Laith J Abu-Raddad
BACKGROUND: Understanding the epidemiology of HIV and other sexually transmitted infections (STIs) requires knowledge of sexual behavior, but self-reported behavior has limitations. We explored the reliability and validity of nonpaternity and half-siblings ratios as biomarkers of current and past extramarital sex. METHODS: An individual-based Monte Carlo simulation model was constructed to describe partnering and conception in human populations with a focus on Sub-Saharan Africa (SSA)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904199/calcitonin-gene-related-peptide-induces-hiv-1-proteasomal-degradation-in-mucosal-langerhans-cells
#19
Morgane Bomsel, Yonatan Ganor
The neuro-immune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens. LCs rapidly internalize human immunodeficiency virus type 1 (HIV-1) upon its sexual transmission and then trans-infect CD4+ T-cells. We recently found that the neuropeptide calcitonin gene-related peptide (CGRP), secreted mucosally from peripheral neurons, inhibits LCs-mediated HIV-1 trans-infection. Herein, we investigated the mechanism of CGRP-induced inhibition, focusing on HIV-1 degradation in LCs and its interplay with trans-infection...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28903180/diamine-derivative-anti-trichomonas-vaginalis-and-anti-tritrichomonas-foetus-activities-by-effect-on-polyamine-metabolism
#20
Graziela Vargas Rigo, Márcia Rodrigues Trein, Danielle da Silva Trentin, Alexandre José Macedo, Bruno Assis de Oliveira, Angelina Maria de Almeida, Raquel Brandt Giordani, Mauro Vieira de Almeida, Tiana Tasca
Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated...
September 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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