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https://www.readbyqxmd.com/read/27914213/parental-support-for-human-papilloma-virus-vaccination-by-adolescents-in-ibadan-north-local-government-area-ibadan-nigeria
#1
Magbagbeola David Dairo, Moradeke Omoyemi Adeleke, Adetokunbo Taophic Salawu, Ayobami David Adewole
BACKGROUND: Despite changing sexual norms and mores generally perceived to be permissive of sexual expression, parents continue to serve as gateways to uptake of reproductive health services and commodities in our cultural settings. However, their support for adolescent uptake of human papilloma virus (HPV) vaccine are not well explored and documented. This study aims to assess parental knowledge and awareness of HPV infection and cervical cancer and their support for HPV vaccination for their adolescent children...
December 3, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27913230/effects-of-combined-oral-contraceptives-depot-medroxyprogesterone-acetate-and-the-levonorgestrel-releasing-intrauterine-system-on-the-vaginal-microbiome
#2
J Paul Brooks, David J Edwards, Diana L Blithe, Jennifer M Fettweis, Myrna G Serrano, Nihar U Sheth, Jerome F Strauss, Gregory A Buck, Kimberly K Jefferson
OBJECTIVES: Prior studies suggest that the composition of the vaginal microbiome may positively or negatively affect susceptibility to sexually transmitted infections (STI) and bacterial vaginosis (BV). Some female hormonal contraceptive methods also appear to positively or negatively influence STI transmission and BV. Therefore changes in the vaginal microbiome that are associated with different contraceptive methods may explain, in part, effects on STI transmission and BV. STUDY DESIGN: We performed a retrospective study of 16S rRNA gene survey data of vaginal samples from a subset of participants from the Human Vaginal Microbiome Project at Virginia Commonwealth University...
November 29, 2016: Contraception
https://www.readbyqxmd.com/read/27912985/immunogenicity-and-malaria-transmission-reducing-potency-of-pfs48-45-and-pfs25-encoded-by-dna-vaccines-administered-by-intramuscular-electroporation
#3
Dibyadyuti Datta, Geetha P Bansal, Dietlind L Gerloff, Barry Ellefsen, Drew Hannaman, Nirbhay Kumar
Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system during infection in the human host also makes it ideal for natural boosting. However, it has been challenging to produce a fully folded, functionally active Pfs48/45, using various protein expression platforms. In this study, we demonstrate that full-length Pfs48/45 encoded by DNA plasmids is able to induce significant transmission reducing immune responses...
November 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27910886/sequential-information-in-a-great-ape-utterance
#4
Pawel Fedurek, Klaus Zuberbühler, Christoph D Dahl
Birdsong is a prime example of acoustically sophisticated vocal behaviour, but its complexity has evolved mainly through sexual selection to attract mates and repel sexual rivals. In contrast, non-human primate calls often mediate complex social interactions, but are generally regarded as acoustically simple. Here, we examine arguably the most complex call in great ape vocal communication, the chimpanzee (Pan troglodytes schweinfurthii) 'pant hoot'. This signal consists of four acoustically distinct phases: introduction, build-up, climax and let-down...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908293/autosomal-genetic-control-of-human-gene-expression-does-not-differ-across-the-sexes
#5
Irfahan Kassam, Luke Lloyd-Jones, Alexander Holloway, Kerrin S Small, Biao Zeng, Andrew Bakshi, Andres Metspalu, Greg Gibson, Tim D Spector, Tonu Esko, Grant W Montgomery, Joseph E Powell, Jian Yang, Peter M Visscher, Allan F McRae
BACKGROUND: Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression. RESULTS: In this study, we use data from a mixture of pedigree and unrelated individuals with verified European ancestry to investigate the sex-specific genetic architecture of gene expression measured in whole blood across n=1048 males and n=1005 females by treating gene expression intensities in the sexes as two distinct traits and estimating the genetic correlation (r G) between them...
December 1, 2016: Genome Biology
https://www.readbyqxmd.com/read/27907884/factors-determining-human-to-human-transmissibility-of-zoonotic-pathogens-via-contact
#6
REVIEW
Mathilde Richard, Sascha Knauf, Philip Lawrence, Alison E Mather, Vincent J Munster, Marcel A Müller, Derek Smith, Thijs Kuiken
The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission...
November 28, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27907089/detection-of-human-papillomavirus-infection-in-patients-with-vaginal-intraepithelial-neoplasia
#7
Cristina Lamos, Charlotte Mihaljevic, Sebastian Aulmann, Thomas Bruckner, Christoph Domschke, Markus Wallwiener, Carmen Paringer, Herbert Fluhr, Sarah Schott, Christine Dinkic, Janina Brucker, Michael Golatta, Lisa Gensthaler, Michael Eichbaum, Christof Sohn, Joachim Rom
INTRODUCTION: Vaginal intraepithelial neoplasia (VAIN) is a pre-malignant lesion, potentially leading to vaginal cancer. It is a rare disease, representing less than 1% of all intraepithelial neoplasia of the female genital tract. Similar to cervical intraepithelial neoplasia (CIN), there are three different grades of VAIN. VAIN 1 is also known as a low-grade squamous intraepithelial lesion (LSIL), whereas VAIN 2 and VAIN 3 both represent high-grade squamous intraepithelial lesions (HSIL)...
2016: PloS One
https://www.readbyqxmd.com/read/27906881/stem-cells-and-clinical-practice-new-advances-and-challenges-at-the-time-of-emerging-problems-with-induced-pluripotent-stem-cell-therapies
#8
Mariusz Z Ratajczak, Kamila Bujko, Wojciech Wojakowski
Humans, like other species that reproduce sexually, originate from a fertilized oocyte (zygote), which is a totipotent stem cell giving rise to an adult organism. During the process of embryogenesis, stem cells at different levels of the developmental hierarchy establish all 3 germ layers and give rise to tissue‑committed stem cells, which are responsible for rejuvenation of a given tissue or organ. The robustness of the stem cell compartment is one of the major factors that directly impact life quality as well as lifespan...
November 10, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27906806/awareness-of-cervical-cancer-causes-and-predeterminants-of-likelihood-to-screen-among-women-in-haiti
#9
Schatzi H McCarthy, Kathy A Walmer, Joel C Boggan, Margaret W Gichane, William A Calo, Harry A Beauvais, Noel T Brewer
OBJECTIVES: Cervical cancer is the leading cause of cancer deaths among women in Haiti. Given this high disease burden, we sought to better understand women's knowledge of its causes and the sociodemographic and health correlates of cervical cancer screening. MATERIALS AND METHODS: Participants were 410 adult women presenting at clinics in Léogâne and Port-au-Prince, Haiti. We used bivariate and multivariate logic regression to identify correlates of Pap smear receipt...
November 30, 2016: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/27905998/sexually-transmitted-infections-and-pre-exposure-prophylaxis-challenges-and-opportunities-among-men-who-have-sex-with-men-in-the-us
#10
REVIEW
Hyman M Scott, Jeffrey D Klausner
Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM...
January 19, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905473/carcinogenic-human-papillomavirus-infection
#11
Mark Schiffman, John Doorbar, Nicolas Wentzensen, Silvia de Sanjosé, Carole Fakhry, Bradley J Monk, Margaret A Stanley, Silvia Franceschi
Infections with human papillomavirus (HPV) are common and transmitted by direct contact. Although the great majority of infections resolve within 2 years, 13 phylogenetically related, sexually transmitted HPV genotypes, notably HPV16, cause - if not controlled immunologically or by screening - virtually all cervical cancers worldwide, a large fraction of other anogenital cancers and an increasing proportion of oropharyngeal cancers. The carcinogenicity of these HPV types results primarily from the activity of the oncoproteins E6 and E7, which impair growth regulatory pathways...
December 1, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27904805/hypothesis-on-serenoa-repens-bartram-small-extract-inhibition-of-prostatic-5%C3%AE-reductase-through-an-in-silico-approach-on-5%C3%AE-reductase-x-ray-structure
#12
Paolo Governa, Daniela Giachetti, Marco Biagi, Fabrizio Manetti, Luca De Vico
Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor antagonists and 5α-reductase inhibitor, there is a large requirement for treatments with less adverse events on, e.g., blood pressure and sexual function: phytotherapy may be the right way to fill this need. Serenoa repens standardized extract has been widely studied and its ability to reduce lower urinary tract symptoms related to benign prostatic hyperplasia is comprehensively described in literature...
2016: PeerJ
https://www.readbyqxmd.com/read/27903871/decline-and-recovery-of-a-large-carnivore-environmental-change-and-long-term-trends-in-an-endangered-brown-bear-population
#13
Isabel Martínez Cano, Fernando González Taboada, Javier Naves, Alberto Fernández-Gil, Thorsten Wiegand
Understanding what factors drive fluctuations in the abundance of endangered species is a difficult ecological problem but a major requirement to attain effective management and conservation success. The ecological traits of large mammals make this task even more complicated, calling for integrative approaches. We develop a framework combining individual-based modelling and statistical inference to assess alternative hypotheses on brown bear dynamics in the Cantabrian range (Iberian Peninsula). Models including the effect of environmental factors on mortality rates were able to reproduce three decades of variation in the number of females with cubs of the year (Fcoy), including the decline that put the population close to extinction in the mid-nineties, and the following increase in brown bear numbers...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27902759/seroprevalence-and-associated-factors-of-9-valent-human-papillomavirus-hpv-types-among-men-in-the-multinational-him-study
#14
Shams Rahman, Christine M Pierce Campbell, Dana E Rollison, Wei Wang, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Anna R Giuliano
BACKGROUND: Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Recently a 9-valent HPV (9vHPV) prophylactic vaccine was licensed. Seroprevalence prior to vaccine dissemination is needed for monitoring vaccine effectiveness over time. Few studies have assessed the seroprevalence of 9vHPV types in men. OBJECTIVES: To investigate the seroprevalence of 9vHPV vaccine types and associated risk factors among men residing in Brazil, Mexico, and the United States...
2016: PloS One
https://www.readbyqxmd.com/read/27902685/getting-to-the-bottom-of-face-processing-species-specific-inversion-effects-for-faces-and-behinds-in-humans-and-chimpanzees-pan-troglodytes
#15
Mariska E Kret, Masaki Tomonaga
For social species such as primates, the recognition of conspecifics is crucial for their survival. As demonstrated by the 'face inversion effect', humans are experts in recognizing faces and unlike objects, recognize their identity by processing it configurally. The human face, with its distinct features such as eye-whites, eyebrows, red lips and cheeks signals emotions, intentions, health and sexual attraction and, as we will show here, shares important features with the primate behind. Chimpanzee females show a swelling and reddening of the anogenital region around the time of ovulation...
2016: PloS One
https://www.readbyqxmd.com/read/27902363/seroprevalence-of-cutaneous-human-papillomaviruses-hpv-among-men-in-the-multinational-him-study
#16
Shams Rahman, Christine M Pierce Campbell, Tim Waterboer, Dana E Rollison, Donna J Ingles, B Nelson Torres, Angelika Michel, Staci L Sudenga, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Amy R Borenstein, Wei Wang, Anna R Giuliano
Data on cutaneous HPV seroprevalence is primarily derived from skin cancer case-controls studies. Few studies have reported the seroprevalence of cutaneous HPV among healthy men. This study investigated the seroprevalence of cutaneous HPV types and associated risk factors among men residing in Brazil, Mexico, and the United States. Six hundred men were randomly selected from the HPV Infection in Men (HIM) Study. Archived serum specimens were tested for antibodies against 14 cutaneous HPV genotypes, β-HPV types (5/8/12/14/17/22/23/24/38/48), α-HPV 27, γ-HPV 4, µ-HPV1 and ν-HPV 41 using a GST L1-based multiplex serology assay...
October 6, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27901106/the-role-of-pim1-pim2-kinases-in-tumors-of-the-male-reproductive-system
#17
Manuel Pedro Jiménez-García, Antonio Lucena-Cacace, María José Robles-Frías, Maja Narlik-Grassow, Carmen Blanco-Aparicio, Amancio Carnero
The PIM family of serine/threonine kinases has three highly conserved isoforms (PIM1, PIM2 and PIM3). PIM proteins are regulated through transcription and stability by JAK/STAT pathways and are overexpressed in hematological malignancies and solid tumors. The PIM kinases possess weak oncogenic abilities, but enhance other genes or chemical carcinogens to induce tumors. We generated conditional transgenic mice that overexpress PIM1 or PIM2 in male reproductive organs and analyzed their contribution to tumorigenesis...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900931/hiv-positive-migrants-encounters-with-the-swedish-health-care-system
#18
Manijeh Mehdiyar, Rune Andersson, Katarina Hjelm, Lene Povlsen
BACKGROUND: There is limited knowledge about human immunodeficiency virus (HIV)-positive migrants and their experiences in the Swedish health care system. It is necessary to increase our knowledge in this field to improve the quality of care and social support for this vulnerable group of patients. OBJECTIVE: The aim of this study was to describe the experiences of HIV-positive migrants and their encounters with the health care system in Sweden. DESIGN: This is a Grounded Theory study based on qualitative interviews with 14 HIV-positive migrants living in Sweden, aged 29-55 years...
2016: Global Health Action
https://www.readbyqxmd.com/read/27899728/evolution-of-sex-differences-in-trait-and-age-specific-vulnerabilities
#19
David C Geary
Traits that facilitate competition for reproductive resources or that influence mate choice generally have a heightened sensitivity to stressors. They have evolved to signal resilience to infectious disease and nutritional and social stressors, and they are compromised by exposure to man-made toxins. Although these traits can differ from one species or sex to the next, an understanding of the dynamics of competition and choice can in theory be used to generate a priori predictions about sex-, age-, and trait-specific vulnerabilities for any sexually reproducing species...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27898576/sexually-transmitted-disease-testing-and-uptake-of-human-papillomavirus-vaccine-in-a-large-online-survey-of-us-men-who-have-sex-with-men-at-risk-for-hiv-infection-2012
#20
Erin M Kahle, Elissa Meites, R Craig Sineath, Muazzam Nasrullah, Kristina E Bowles, Elizabeth DiNenno, Patrick S Sullivan, Travis Sanchez
National guidelines recommend annual human immunodeficiency virus (HIV)/sexually transmitted disease testing for sexually active men who have sex with men (MSM) and vaccination against human papillomavirus for MSM through age 26. A 2012 online survey of 2,794 MSM found that 51%, 36%, and 14% reported receiving human immunodeficiency virus testing, sexually transmitted disease testing, and human papillomavirus vaccination, respectively.
November 28, 2016: Sexually Transmitted Diseases
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