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Premature contraction

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https://www.readbyqxmd.com/read/27909491/idiopathic-vpc-distribution-of-foci-and-tips-of-ablation
#1
REVIEW
Jose C Pachon M Md PhD, Tasso J Lobo Md, Enrique I Pachon M Md, Tomas G Santillana P Md, Carlos Tc Pachon Md, Juan C Pachon M Md, Remy N Albornoz V Md, Juan C Zerpa A Md, Felipe A Ortencio Md
Idiopathic Ventricular Premature Contraction (VPC) is currently more routinely referred for electrophysiology evaluation. Usually it carries a good prognosis but, when symptomatic or suspected to produce ventricular dysfunction, will require treatment. Nowadays, RF ablation has great advantages over antiarrhythmic drugs. Classically the outflow tract (right or left), with the typical inferior axis with left (eventually right) bundle brunch block like ECG morphology, is considered the most frequent site of origin for idiopathic VPC, but with the widespread of EP procedures and advancement of technology making possible to map and ablate difficult locations, it is possible to see a growing and changing population referred for idiopathic VPC ablation, displaying that, almost any region of the heart may be source of this kind of arrhythmia that can be successfully treated...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27906419/sch-79797-a-selective-par1-antagonist-protects-against-ischemia-reperfusion-induced-arrhythmias-in-the-rat-hearts
#2
O Y Mohamed, A A Al-Masri, E A El Eter, R Lateef
OBJECTIVE: Thrombin is implicated in the genesis of arrhythmias and activation of thrombin receptors exacerbated ventricular arrhythmias following coronary artery ligation. The present study was designed to investigate the possible protective effect of the protease-activated receptor-1 antagonist, SCH79797 against ischemia and reperfusion arrhythmias in the rat heart. MATERIALS AND METHODS: Healthy male Wistar rats (250-350 g) were anesthetized with urethane. Coronary artery ligation was performed for 5 minutes followed by 10 minutes reperfusion...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27890733/differences-in-the-onset-mode-of-ventricular-tachyarrhythmia-between-patients-with-j-wave-in-anterior-leads-versus-inferolateral-leads
#3
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
BACKGROUND: The pathophysiological mechanism of J wave in anterior leads (A-leads) and inferolateral leads (L-leads) remains unclear. OBJECTIVE: We investigated the onset mode and circadian distribution of ventricular tachyarrhythmia (VTA) episodes in patients with early repolarization syndrome (ERS) and Brugada syndrome (BrS). METHODS: The study enrolled 35 ERS patients and 52 type 1 BrS patients with spontaneous ventricular fibrillation who were divided into four groups: ERS(A+L) (n=15), ERS patients who had non-type 1 Brugada-pattern electrocardiogram (ECG) in any A-leads (2(nd) to 4(th) intercostal spaces) in control and/or after drug provocation tests; ERS(L) (n=20), ERS with J wave only in L-leads; BrS(A) (n=24), BrS without J wave in L-leads; and, BrS(A+L) (n=28), BrS with J wave in L-leads...
November 23, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27884152/use-of-self-gated-radial-cardiovascular-magnetic-resonance-to-detect-and-classify-arrhythmias-atrial-fibrillation-and-premature-ventricular-contraction
#4
Eve Piekarski, Teodora Chitiboi, Rebecca Ramb, Li Feng, Leon Axel
BACKGROUND: Arrhythmia can significantly alter the image quality of cardiovascular magnetic resonance (CMR); automatic detection and sorting of the most frequent types of arrhythmias during the CMR acquisition could potentially improve image quality. New CMR techniques, such as non-Cartesian CMR, can allow self-gating: from cardiac motion-related signal changes, we can detect cardiac cycles without an electrocardiogram. We can further use this data to obtain a surrogate for RR intervals (valley intervals: VV)...
November 25, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27875822/cellular-senescence-immunosenescence-and-hiv
#5
Tamàs Fülöp, Georges Herbein, Andrea Cossarizza, Jacek M Witkowski, Eric Frost, Gilles Dupuis, Graham Pawelec, Anis Larbi
Aging is a complex biological process that leads to several physiological changes. Among these changes, the most striking are those involving the innate and adaptive parts of the immune system. Furthermore, these changes are associated with a low-grade inflammation called inflamm-aging, which is the result of several lifelong antigenic stimulations, including chronic viral infections such as cytomegalovirus. Immunosenescence, concomitantly with inflamm-aging, is considered as the leading cause of age-related diseases including cardiovascular, neurodegenerative and metabolic diseases, and cancer...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27875131/non-invasive-personalisation-of-a-cardiac-electrophysiology-model-from-body-surface-potential-mapping
#6
Sophie Giffard-Roisin, Thomas Jackson, Lauren Fovargue, Jack Lee, Herve Delingette, Reza Razavi, Nicholas Ayache, Maxime Sermesant
Modelling cardiac electrophysiology (EP) can help understand pathologies and predict the response to therapies. Moreover, estimating patient-specific parameters of the EP model is crucial to obtain personalised information. The novelty of this paper is to use non-invasive data (body surface potential mapping, BSPM) in order to personalise the main parameters of a cardiac EP model for predicting different pacing conditions. First, an efficient forward model is proposed, coupling the Mitchell- Schaeffer transmembrane potential model with a current dipole formulation...
November 16, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27867361/calcium-sensing-receptor-regulates-cytosolic-ca-2-and-plays-a-major-role-in-the-development-of-pulmonary-hypertension
#7
REVIEW
Kimberly A Smith, Ramon J Ayon, Haiyang Tang, Ayako Makino, Jason X-J Yuan
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death. The increased PVR results in part from pulmonary vascular remodeling and sustained pulmonary vasoconstriction. Excessive pulmonary vascular remodeling stems from increased pulmonary arterial smooth muscle cell (PASMC) proliferation and decreased PASMC apoptosis. A rise in cytosolic free Ca(2+) concentration ([Ca(2+)]cyt) in PASMC is a major trigger for pulmonary vasoconstriction and a key stimulus for PASMC proliferation and migration, both contributing to the development of pulmonary vascular remodeling...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27867290/ranolazine-is-an-effective-and-safe-treatment-of-adults-with-symptomatic-premature-ventricular-contractions-due-to-triggered-ectopy
#8
Gary L Murray
Early and delayed afterdepolarizations (EAD/DAD) cause triggered ventricular ectopy. Because ranolazine (RAN) suppresses EAD/DAD, we postulated that RAN might be effective in reducing premature ventricular contractions (PVCs). To assess the effect of RAN in patients with symptomatic PVCs due to triggered ectopy and its safety and tolerability. A total of 59 patients with symptomatic PVCs were identified from full-disclosure Holters. Doses of 500 and 1,000 mg offlabel RAN, daily, were given to 34 and 66% patients, respectively, and repeat Holters were performed prospectively during mean followup of 3...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27862484/%C3%AE-1-adrenoceptor-autoantibodies-increase-the-susceptibility-of-ventricular-arrhythmias-involving-abnormal-repolarization-in-guinea-pigs
#9
Yu-Hui Zhao, Hai-Xia Huang, Ping Liu, Yun-Hui Du, Peng Wang, Wen Wang, Ye Wu, Li Wang, Chang-Sheng Ma, Hui-Rong Liu
High titers of autoantibodies against the second extracellular loop of β1 -adrenergic receptors (β1 -AA) can be detected in the sera from patients with ventricular arrhythmias, but a causal relationship between β1 -AAs and ventricular arrhythmias has not been established. In this work, electrocardiograms of guinea pigs and isolated guinea pig hearts were recorded. Ventricular tachycardia (VT) and ventricular fibrillation (VF) were evoked by programmed electrical stimulation of the left ventricular epicardium of isolated guinea pig hearts...
November 11, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27859845/interpolated-premature-ventricular-contraction-initiating-a-supraventricular-tachycardia-what-is-the-mechanism
#10
Marek Jastrzębski, Piotr Kukla, Danuta Czarnecka
No abstract text is available yet for this article.
November 18, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27833773/a-fatal-case-of-congenital-langerhans-cell-histiocytosis-with-disseminated-cutaneous-lesions-in-a-premature-neonate
#11
Michio Inoue, Yoko Tomita, Tsuyoshi Egawa, Tomoaki Ioroi, Masaaki Kugo, Shinsaku Imashuku
Background. The outcome of neonates with congenital cutaneous Langerhans cell histiocytosis (LCH) is variable. Observations. We report a case of LCH in a female premature neonate born at 33-week gestation. She had disseminated cutaneous lesions, which consisted of hemorrhagic papules and vesicles, with sparse healthy skin areas, and the hands and feet were contracted with scarring and blackened. She was in respiratory failure although no apparent pulmonary or bone lesions on X-rays were noted. Skin biopsy confirmed a diagnosis of LCH due to observation of CD1a(+) Langerhans cells, which lacked expression of E-cadherin and CD56...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27799254/phosphodiesterase-2-protects-against-catecholamine-induced-arrhythmia-and-preserves-contractile-function-after-myocardial-infarction
#12
Christiane Vettel, Marta Lindner, Matthias Dewenter, Kristina Lorenz, Constanze Schanbacher, Merle Riedel, Simon Lämmle, Simone Meinecke, Fleur E Mason, Samuel Sossalla, Andreas Geerts, Michael Hoffmann, Frank Wunder, Fabian J Brunner, Thomas Wieland, Hind Mehel, Sarah Karam, Patrick Lechêne, Jérôme Leroy, Grégoire Vandecasteele, Michael Wagner, Rodolphe Fischmeister, Ali El-Armouche
RATIONALE: Phosphodiesterase 2 (PDE2) is a dual substrate esterase, which has the unique property to be stimulated by cGMP, but primarily hydrolyses cAMP. Myocardial PDE2 is upregulated in human heart failure (HF), but its role in the heart is unknown. OBJECTIVE: To explore the role of PDE2 in cardiac function, propensity to arrhythmia and in myocardial infarction. METHODS AND RESULTS: Pharmacological inhibition of PDE2 (BAY 60-7550, BAY) led to a significant positive chronotropic effect on top of maximal β-adrenoceptor (β-AR) activation in healthy mice...
October 31, 2016: Circulation Research
https://www.readbyqxmd.com/read/27798051/risk-factors-for-premature-ventricular-contractions-in-young-and-healthy-adults
#13
Mirco von Rotz, Stefanie Aeschbacher, Matthias Bossard, Tobias Schoen, Steffen Blum, Susanna Schneider, Joel Estis, John Todd, Martin Risch, Lorenz Risch, David Conen
BACKGROUND: Premature ventricular contractions (PVCs) are associated with an increased risk of morbidity and mortality. Therefore, it was aimed to assess risk factors for the frequency of PVCs in young and healthy adults. METHODS: Our population-based study included 2048 healthy adults from the general population aged 25-41 years. PVC frequency was determined by 24-hour Holter ECG. We performed multivariable regression analysis using stepwise backward selection to identify factors independently associated with PVC frequency...
October 21, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27794538/methyl-cpg-binding-protein-2-function-in-cholinergic-neurons-mediates-cardiac-arrhythmogenesis
#14
José A Herrera, Christopher S Ward, Xander H T Wehrens, Jeffrey L Neul
Sudden unexpected death occurs in one quarter of deaths in Rett Syndrome (RTT), a neurodevelopmental disorder caused by mutations in Methyl-CpG-binding protein 2 (MECP2). People with RTT show a variety of autonomic nervous system (ANS) abnormalities and mouse models show similar problems including QTc interval prolongation and hypothermia. To explore the role of cardiac problems in sudden death in RTT, we characterized cardiac rhythm in mice lacking Mecp2 function. Male and female mutant mice exhibited spontaneous cardiac rhythm abnormalities including bradycardic events, sinus pauses, atrioventricular block, premature ventricular contractions, non-sustained ventricular arrhythmias, and increased heart rate variability...
October 18, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27788744/-clinical-analysis-of-19-cases-of-pregnant-women-with-rapid-arrhythmia-in-the-treatment-of-radiofrequency-catheter-ablation
#15
L Chu, J Zhang, Y N Li, D Y Long
: Objective: To investigate the risk of radiofrequency catheter ablation and maternal and infant in pregnant women with rapid arrhythmia during pregnancy. Methods: The clinical data of the 19 cases of pregnancy complicated with rapid arrhythmia were retrospectively analyzed and followed up, including the gestational week, the type of arrhythmia, the treatment, and the outcome of the mother and child in Beijing Anzhen Hospital of Capital Medical University from January 2002 to March 2016...
October 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27781328/preferential-conduction-during-posterior-papillary-muscle-origin-premature-ventricular-contractions-demonstrated-by-pace-mapping
#16
Taihei Itoh, Takumi Yamada
No abstract text is available yet for this article.
October 25, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27756708/a-type-2-ryanodine-receptor-variant-associated-with-reduced-ca-2-release-and-short-coupled-torsade-de-pointe-ventricular-arrhythmia
#17
Yusuke Fujii, Hideki Itoh, Seiko Ohno, Takashi Murayama, Nagomi Kurebayashi, Hisaaki Aoki, Malorie Blancard, Yoshihisa Nakagawa, Satoshi Yamamoto, Yumie Matsui, Mari Ichikawa, Keiko Sonoda, Tomoya Ozawa, Kimie Ohkubo, Ichiro Watanabe, Pascale Guicheney, Minoru Horie
BACKGROUND: Ventricular fibrillation (VF) may be caused by premature ventricular contractions (PVCs) whose coupling intervals are under 300ms, a characteristic of scTdP. OBJECTIVE: The purpose of this study is to analyze the underlying RyR2 variants in patients with the short-coupled variant of torsade de pointes (scTdP). METHODS: Seven patients with scTdP (34±12 years old, 3 females) were enrolled in this study. The RyR2 gene was screened by targeted gene sequencing methods, and variant minor allele frequency (MAF) was confirmed in three databases, and the pathogenicity was investigated in multiple in silico tools...
October 15, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27754285/me-04-3-epidemiology-and-consequences-of-early-vascular-aging
#18
Junichiro Hashimoto
Arterial structure and function change progressively with advancing age. Owing to long-lasting repetitive stretch with intermittent cardiac contraction, elastic fibers in the tunica media of large arteries gradually degenerate and are replaced by collagenous fibers. Such medial degeneration causes elastic arteries to stiffen and dilate. However, the speed of the vascular aging varies considerably among individuals; a discrepancy often exists between the chronological age of an individual and the biological age of his or her arteries...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753589/chorioamniotic-membrane-separation-found-on-routine-testing-in-an-otherwise-asymptomatic-woman-with-late-preterm-twin-gestation
#19
Sarah M Holmen, Tiki Bakhshi, Maria M Molina, Larissa F Weir
BACKGROUND: Chorioamniotic membrane separation (CMS) is a rare finding that is commonly preceded by invasive fetal procedures. The presence of CMS can also be associated with uncommon maternal or fetal conditions as well as preterm delivery, amniotic band syndrome, umbilical cord complications, and fetal and neonatal death. It is classified as a high-risk antepartum condition due to the significant fetal morbidity and mortality that may ensue. CASE REPORT: A 40-year-old gravida 5 para 1212 at 35 weeks presented for antepartum fetal testing...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27753176/jackhammer-esophagus-observations-on-a-european-cohort
#20
T V K Herregods, A J P M Smout, J L S Ooi, D Sifrim, A J Bredenoord
BACKGROUND: With the advent of high-resolution manometry (HRM), a new diagnosis, jackhammer esophagus, was introduced. Little is known about this rare condition, and the relationship between symptoms and hypercontractility is not always straightforward. The aim of our study was to describe a large cohort of patients with jackhammer esophagus and to investigate whether manometric findings are associated with the presence of symptoms. METHODS: All patients from 06, 2014 until 12, 2015 seen at two tertiary centers with at least one hypercontractile swallow (distal contractile integral [DCI] >8000 mm Hg/s/cm) on HRM were analyzed...
October 17, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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