keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#2
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536623/gut-barrier-dysfunction-and-the-risk-of-icu-acquired-bacteremia-a-case-control-study
#3
JOURNAL ARTICLE
Meri R J Varkila, Diana M Verboom, Lennie P G Derde, Tom van der Poll, Marc J M Bonten, Olaf L Cremer
BACKGROUND: Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin. METHODS: We conducted a nested case-control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38536458/scabies-in-infants-and-children-a-narrative-review
#4
REVIEW
Anca E Chiriac, Adriana Diaconeasa, Raluca Miulescu, Uwe Wollina
Scabies is a human ectoparasitosis caused by Sarcoptes scabei var. hominis. World-wide around 300 million patients are affected. Infants and children have the highest incidence rates. Poverty and overcrowding are social factors contributing to a higher risk of transmission and treatment failure. The leading symptom of the infestation is itch. Complications are bacterial infections that are responsible for mortality. Diagnosis is clinical. Non-invasive imaging technologies like dermoscopy can be used. Polymerase chain reaction (PCR) is less sensitive and specific than microscopy of skin scrapings...
March 27, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38536097/macrophage-polarization-dynamics-in-biomaterials-implications-for-in-vitro-wound-healing
#5
JOURNAL ARTICLE
Pravin Shankar Giri, Subha Narayan Rath
The interaction between biomaterials and the immune system plays a pivotal role in determining the success or failure of implantable devices. Macrophages, as key orchestrators of immune responses, exhibit diverse reactions that influence tissue integration or lead to implant failure. This study focuses on unraveling the intricate relationship between macrophage phenotypes and biomaterials, specifically hydrogels, by employing THP-1 cells as a model. Through a comprehensive investigation using polysaccharide, polymer, and protein-based hydrogels, our research sheds light on how the properties of hydrogels influence macrophage polarization...
March 27, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38535599/alterations-in-n-glycosylation-of-hcv-e2-protein-in-children-patients-with-ifn-rbv-therapy-failure
#6
JOURNAL ARTICLE
Karolina Zimmer, Alicja M Chmielewska, Paulina Jackowiak, Marek Figlerowicz, Krystyna Bienkowska-Szewczyk
The glycosylation of viral envelope proteins plays an important role in virus biology and the immune response of the host to infection. Hepatitis C virus (HCV) envelope proteins E1 and E2, key players in virus entry and spread, are highly N-glycosylated and possess 4 (5 in certain genotypes) to 11 conserved glycosylation sites, respectively. Many published results based on recombinant proteins indicate that the glycan shield can mask the epitopes targeted by neutralizing antibodies. Glycan shifting within the conserved linear E2 region (412-423) could be one of the escape strategies used by HCV...
March 15, 2024: Pathogens
https://read.qxmd.com/read/38535253/three-dimensional-printing-methods-for-bioceramic-based-scaffold-fabrication-for-craniomaxillofacial-bone-tissue-engineering
#7
REVIEW
Zeeshan Sheikh, Vasudev Vivekanand Nayak, Umer Daood, Anupreet Kaur, Hanan Moussa, Abbas Canteenwala, Pierre-Luc Michaud, Ísis de Fátima Balderrama, Edisa de Oliveira Sousa, Nick Tovar, Andrea Torroni, Michael Glogauer, Huzefa Talib, Paulo G Coelho, Lukasz Witek
Three-dimensional printing (3DP) technology has revolutionized the field of the use of bioceramics for maxillofacial and periodontal applications, offering unprecedented control over the shape, size, and structure of bioceramic implants. In addition, bioceramics have become attractive materials for these applications due to their biocompatibility, biostability, and favorable mechanical properties. However, despite their advantages, bioceramic implants are still associated with inferior biological performance issues after implantation, such as slow osseointegration, inadequate tissue response, and an increased risk of implant failure...
March 1, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535079/skin-lesions-with-loss-of-tissue-and-cutaneous-onset-sepsis-the-skin-infection-sepsis-relationship
#8
JOURNAL ARTICLE
Adriana-Ionela Pătrașcu, Dan Vâță, Doinița Temelie-Olinici, Mădălina Mocanu, Dumitrița-Lenuța Guguluș, Mădălina Marinescu, Liviu Stafie, Bogdan-Marian Tarcău, Ioana Creţu, Ioana-Adriana Popescu, Carmen-Diana Cimpoeșu, Laura Gheucă-Solovăstru
Infectious and inflammatory dermatoses featuring skin lesions with loss of tissue expose skin layers to microbial invasions, disrupt the normal skin microbiome, and potentially lead to sepsis. However, literature data on the incidence of cutaneous-onset sepsis are scarce. This retrospective observational study assessed hospital admissions for primary skin lesions without bacterial infections and sepsis during 2020-2022 in the largest emergency hospital in NE Romania. Of 509 patients, 441 had infected lesions, 78 had sepsis caused by venous ulcers from microbial eczema cellulitis, superinfected bullous dermatoses, erysipelas, and erythroderma...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534957/comparative-effectiveness-and-safety-of-trastuzumab-biosimilars-to-herceptin-for-adjuvant-treatment-of-her2-breast-cancer
#9
JOURNAL ARTICLE
Caroline Muñoz, Xiaochen Tai, Jessica Arias, Andrea Eisen, Munaza Chaudhry, Scott Gavura, Kelvin K W Chan
Background: Ontario publicly funds reference trastuzumab (Herceptin) and four biosimilar trastuzumab products for adjuvant treatment of HER2+ breast cancer. We assessed the real-world safety and effectiveness of biosimilar trastuzumab compared to Herceptin for adjuvant treatment of patients with HER2+ breast cancer. Methods: This was a population-based, retrospective study comparing the safety and effectiveness of biosimilar trastuzumab and Herceptin for neoadjuvant/adjuvant treatment of HER2+ breast cancer from 2016 to 2021...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534716/assessment-of-colistin-heteroresistance-among-multidrug-resistant-klebsiella-pneumoniae-isolated-from-intensive-care-patients-in-europe
#10
JOURNAL ARTICLE
Anouk J M M Braspenning, Sahaya Glingston Rajakani, Adwoa Sey, Mariem El Bounja, Christine Lammens, Youri Glupczynski, Surbhi Malhotra-Kumar
Heteroresistance (HR) to colistin is especially concerning in settings where multi-drug-resistant (MDR) K. pneumoniae are prevalent and empiric use of colistin might lead to treatment failures. This study aimed to assess the frequency of occurrence of colistin HR (CHR) among (MDR) K. pneumoniae ( n = 676) isolated from patients hospitalized in 13 intensive care units (ICUs) in six European countries in a clinical trial assessing the impact of decolonization strategies. All isolates were whole-genome-sequenced and studied for in vitro colistin susceptibility...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534620/effect-of-hydrogel-stiffness-on-chemoresistance-of-breast-cancer-cells-in-3d-culture
#11
JOURNAL ARTICLE
Tianjiao Zeng, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Chemotherapy is one of the most common strategies for cancer treatment, whereas drug resistance reduces the efficiency of chemotherapy and leads to treatment failure. The mechanism of emerging chemoresistance is complex and the effect of extracellular matrix (ECM) surrounding cells may contribute to drug resistance. Although it is well known that ECM plays an important role in orchestrating cell functions, it remains exclusive how ECM stiffness affects drug resistance. In this study, we prepared agarose hydrogels of different stiffnesses to investigate the effect of hydrogel stiffness on the chemoresistance of breast cancer cells to doxorubicin (DOX)...
March 17, 2024: Gels
https://read.qxmd.com/read/38534497/a-study-of-the-associated-risk-factors-for-early-failure-and-the-effect-of-photofunctionalisation-in-full-arch-immediate-loading-treatment-based-on-the-all-on-four-concept
#12
JOURNAL ARTICLE
Takashi Uesugi, Yoshiaki Shimoo, Motohiro Munakata, Yu Kataoka, Daisuke Sato, Kikue Yamaguchi, Minoru Sanda, Michiya Fujimaki, Kazuhisa Nakayama, Tae Watanabe, Paulo Malo
Early implant failure occurring within 1 year after implantation has been attributed to various factors. Particularly, early failure can lead to challenges in maintaining a full-arch prosthetic device, necessitating prompt intervention, including reoperation. This study aimed to retrospectively examine implant- and patient-related factors and the effects of photofunctionalisation associated with early failure in patients who underwent treatment using the all-on-four concept in both the maxilla and mandible...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38533967/impact-of-a-medical-fitness-model-on-incident-major-adverse-cardiovascular-events-a-prospective-cohort-study-of-11%C3%A2-000-members
#13
JOURNAL ARTICLE
Ranveer Brar, Reid H Whitlock, Alan Katz, Michelle Di Nella, Paul Komenda, Clara Bohm, Claudio Rigatto, Navdeep Tangri, Carrie Solmundson, David Collister
BACKGROUND: Cardiovascular disease remains the leading cause of disease burden and death in the world. The medical fitness model may be an alternative public health strategy to address cardiovascular risk factors with medical integrated programming. METHODS AND RESULTS: We performed a retrospective cohort study between January 1, 2005, and December 31, 2015. Adults (aged ≥18 years) who did not have a prior major adverse cardiovascular event were included...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533053/il-22-promotes-liver-regeneration-after-portal-vein-ligation
#14
JOURNAL ARTICLE
Tao Zhang, Philipp Seeger, Yashin Simsek, Morsal Sabihi, Jöran Lücke, Dimitra E Zazara, Ahmad Mustafa Shiri, Jan Kempski, Tom Blankenburg, Lilan Zhao, Ioannis Belios, Andres Machicote, Baris Mercanoglu, Mohammad Fard-Aghaie, Sara Notz, Panagis M Lykoudis, Marius Kemper, Tarik Ghadban, Oliver Mann, Thilo Hackert, Jakob R Izbicki, Thomas Renné, Samuel Huber, Anastasios D Giannou, Jun Li
BACKGROUND: Insufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to liver failure and mortality. Portal vein ligation (PVL) prior to hepatectomy is subsequently introduced to increase the remnant liver volume and improve the outcome of hepatic malignancy. IL-22 has previously been reported to promote liver regeneration, while facilitating tumor development in the liver via Steap4 upregulation. Here we performed PVL in mouse models to study the role of IL-22 in liver regeneration post-PVL...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532828/clinical-characteristics-and-microorganisms-isolated-in-community-acquired-pneumonia-in-the-covid-19-period
#15
JOURNAL ARTICLE
Meritxell Gavalda, Maria Isabel Fullana, Adrià Ferre, Rebecca Rowena Peña, Julen Armendariz, Orla Torrallardona, Aina Magraner, Alejandro Lorenzo, Carles García, Gemma Mut, Lluís Planas, Carla Iglesias, Pablo Fraile-Ribot, Maria Dolores Macia Romero, Melchor Riera, Mercedes García-Gasalla
INTRODUCTION: Community-acquired pneumonia is a leading cause of mortality and hospital admissions. The aetiology remains unknown in 30-65% of the cases. Molecular tests are available for multiple pathogen detection and are under research to improve the causal diagnosis. METHODS: We carried out a prospective study to describe the clinical characteristics and aetiology of community-acquired pneumonia during the COVID-19 pandemic and to assess the diagnostic effectivity of the microbiological tests, including a molecular test of respiratory pathogens (FilmArray™ bioMérieux)...
2024: Canadian Journal of Infectious Diseases & Medical Microbiology
https://read.qxmd.com/read/38532609/proton-pump-inhibitors-enhance-macropinocytosis-mediated-extracellular-vesicle-endocytosis-by-inducing-membrane-v-atpase-assembly
#16
JOURNAL ARTICLE
Xinliang Lu, Zhengbo Song, Jiayue Hao, Xianghui Kong, Weiyi Yuan, Yingying Shen, Chengyan Zhang, Jie Yang, Pengfei Yu, Yun Qian, Gensheng Zhang, Huajun Feng, Jianli Wang, Zhenzhai Cai, Zhijian Cai
Besides participating in diverse pathological and physiological processes, extracellular vesicles (EVs) are also excellent drug-delivery vehicles. However, clinical drugs modulating EV levels are still lacking. Here, we show that proton pump inhibitors (PPIs) reduce EVs by enhancing macropinocytosis-mediated EV uptake. PPIs accelerate intestinal cell endocytosis of autocrine immunosuppressive EVs through macropinocytosis, thereby aggravating inflammatory bowel disease. PPI-induced macropinocytosis facilitates the clearance of immunosuppressive EVs from tumour cells, improving antitumor immunity...
April 2024: Journal of Extracellular Vesicles
https://read.qxmd.com/read/38532584/-nutritional-support-treatment-for-short-bowel-syndrome-related-intestinal-failure
#17
REVIEW
J Ke, L Kang
Intestinal failure is a syndrome characterized by a diminished intestinal function that is inadequate to maintain normal digestion and absorption, leading to systemic metabolic disorder and requiring long-term nutritional supplementation to sustain health and growth. Short bowel syndrome (SBS) is one of the primary causes of intestinal failure. Given the significant differences among SBS patients, nutritional treatment strategies should emphasize individualization. This review focuses on SBS, combining its anatomical and pathological characteristics, to introduce nutritional support treatment plans and experiences for patients with intestinal failure...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532523/comparing-the-effects-of-various-%C3%AE-blockers-on-cardiovascular-mortality-in-breast-cancer-patients
#18
JOURNAL ARTICLE
Mantasha Tabassum, Soumya G Chikermane, Camille Johnson, Noor M Abdulkareem, Elisabeth M Wang, Michael L Johnson, Meghana V Trivedi
BACKGROUND: Cardiovascular (CV) disease is a leading cause of death in breast cancer (BC) patients due to the increased age and treatments. While individual β-blockers have been investigated to manage CV complications, various β-blockers have not been compared for their effects on CV death in this population. We aimed to compare CV mortality in older BC patients taking one of the commonly used β-blockers. METHODS: This retrospective cohort study was conducted using the Surveillance, Epidemiology and End Results (SEER) - Medicare data (2010-2015)...
March 26, 2024: Cardio-Oncology
https://read.qxmd.com/read/38532484/which-roads-lead-to-access-a-global-landscape-of-six-covid-19-vaccine-innovation-models
#19
JOURNAL ARTICLE
Adrián Alonso Ruiz, Anna Bezruki, Erika Shinabargar, Kaitlin Large, Marcela Vieira, Iulia Slovenski, Yiqi Liu, Surabhi Agarwal, Anna Becker, Suerie Moon
BACKGROUND: Unequal and inequitable access to Covid-19 vaccines in low- and middle-income countries (L&MICs) was a major political, ethical and public health failure in the pandemic. However, vaccine developers' practices were not monolithic, but rather, took diverse approaches to supplying different countries, with important implications for global access. RESULTS: Using data on R&D investments, regulatory approvals, manufacturing and purchase agreements, and vaccine deliveries, we identified six distinct innovation models that apply across the 14 COVID-19 vaccines with more international presence from 2020-2022...
March 26, 2024: Globalization and Health
https://read.qxmd.com/read/38532430/needle%C3%A2-based-gastrocnemius-lengthening-a-novel-ultrasound%C3%A2-guided-noninvasive-technique-part-ii-clinical-results
#20
JOURNAL ARTICLE
A Iborra, M Villanueva, H Fahandezh-Saddi Díaz
BACKGROUND: Isolated gastrocnemius contracture has been associated with more than 30 lower limb disorders, including plantar heel pain/plantar fasciitis, Achilles tendinosis, equinus foot, adult flatfoot, and metatarsalgia. Although many techniques are available for gastrocnemius recession, potential anesthetic, cosmetic, and wound-related complications can lead to patient dissatisfaction. Open and endoscopic recession techniques usually require epidural or general anesthesia, exsanguination of the lower extremities and stitches and can damage the sural nerve, which is not under the complete control of the surgeon at all stages of the procedure...
March 26, 2024: Journal of Orthopaedic Surgery and Research
keyword
keyword
80143
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.