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https://www.readbyqxmd.com/read/28199170/antibody-repertoire-development-in-swine
#1
J E Butler, Nancy Wertz, Marek Sinkora
We describe the domestication of the species, explore its value to agriculture and bioscience, and compare its immunoglobulin (Ig) genes to those of other vertebrates. For encyclopedic information, we cite earlier reviews and chapters. We provide current gene maps for the heavy and light chain loci and describe their polygeny and polymorphy. B-cell and antibody repertoire development is a major focus, and we present findings that challenge several mouse-centric paradigms. We focus special attention on the role of ileal Peyer's patches, the largest secondary lymphoid tissues in newborn piglets and a feature of all artiodactyls...
February 8, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/28193209/secretion-of-biologically-active-pancreatitis-associated-protein-i-pap-by-genetically-modified-dairy-lactococcus-lactis-nz9000-in-the-prevention-of-intestinal-mucositis
#2
Rodrigo D Carvalho, Natalia Breyner, Zelia Menezes-Garcia, Nubia M Rodrigues, Luisa Lemos, Tatiane U Maioli, Danielle da Gloria Souza, Denise Carmona, Ana M C de Faria, Philippe Langella, Jean-Marc Chatel, Luis G Bermúdez-Humarán, Henrique C P Figueiredo, Vasco Azevedo, Marcela S de Azevedo
BACKGROUND: Mucositis is one of the most relevant gastrointestinal inflammatory conditions in humans, generated by the use of chemotherapy drugs, such as 5-fluoracil (5-FU). 5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort. As current therapy drugs presents limitations in alleviating mucositis symptoms, alternative strategies are being pursued. Recent studies have shown that the antimicrobial pancreatitis-associated protein (PAP) has a protective role in intestinal inflammatory processes...
February 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28183153/effects-of-armillariella-tabescens-mycelia-on-the-growth-performance-and-intestinal-immune-response-and-microflora-of-early-weaned-pigs
#3
Wen-Bin Chen, Mao-Ji Cheng, Yun-Bo Tian, Qin-Hua Wang, Bing Wang, Mei-Jun Li, Re-Jun Fang
This study was performed to evaluate effects of Armillariella tabescens (A. tabescens) on the growth performance and intestinal immune response and microflora in early-weaned pigs when used as feed additive. A. tabescens mycelia were added to basal diets at concentrations of 0%, 0.1%, 0.3% or 0.9% (w/w). A total of 144 commercial cross-bred piglets were randomly allocated to one of these four diets and fed for 30 days. The growth performance of early-weaned piglets displayed improvement with diets containing 0...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28162181/-effect-of-serum-interleukin-21-on-b-cell-secretory-capacity-and-apoptosis-in-patients-with-systemic-lupus-erythematosus
#4
L T Zheng, L D Zhao, C Zhao, Y Zhao, X Zhang, F C Zhang, X F Zeng, F L Tang, X You
Objective: To investigate the secretory capacity and apoptosis of interleukin (IL)-21 induced normal B cells by co-culture with serum from patients with systemic lupus erythematosus (SLE). Methods: Serum from twenty new-onset SLE patients and 20 healthy donors were collected. CD(19)(+) B cells from the normal controls were co-cultured with serum from SLE patients in the presence or absence of IL-21-R-FC(4 μg/ml). Supernatant IgG and IgM concentration were measured by immunoturbidimetric assay on day 5. Supernatant anti-dsDNA level was determined by ELISA...
February 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28151031/modulation-by-bovine-lactoferrin-of-parameters-associated-with-the-iga-response-in-the-proximal-and-distal-small-intestine-of-balb-c-mice
#5
Marycarmen Godínez-Victoria, Teresita Rocío Cruz-Hernández, Humberto Reyna-Garfias, Reyna Elizabeth Barbosa-Cabrera, Maria Elisa Drago-Serrano, María Cristina Sánchez-Gómez, Rafael Campos-Rodríguez
BACKGROUND: Secretory IgA (SIgA) and the polymeric immunoglobulin receptor (pIgR) have a pivotal role in gut homeostasis. Bovine lactoferrin (bLf) has been shown to modulate intestinal immunity and endogenous corticosterone. Considering the regionalization of the intestinal immune response, the aim of this work was to compare the impact of bLf on the IgA response in the proximal versus distal small intestine under physiological conditions. METHODS: Groups of healthy male BALB/c mice were orally treated with one daily dose of bLf (50, 500, or 5000 μg) or untreated (control) for 7 d, and then sacrificed...
February 2, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28150752/rainbow-trout-oncorhynchus-mykiss-secretory-component-binds-to-commensal-bacteria-and-pathogens
#6
Cecelia Kelly, Fumio Takizawa, J Oriol Sunyer, Irene Salinas
Commensal bacteria co-exist on the mucosal surfaces of all vertebrates. The host's mucosal immune system must tolerate commensals while fighting pathogens. One of the mechanisms used by the mucosal immune system to maintain homeostasis is the secretion of immunoglobulins (Igs) across epithelial barriers, which is achieved via the polymeric immunoglobulin receptor (pIgR). Rainbow trout pIgR is known to transport IgT and IgM across epithelia. However, other biological functions for trout pIgR or trout secretory component (tSC) remain unknown...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118501/immunoglobulin-a-and-nutrients-in-milk-from-great-apes-throughout-lactation
#7
Miriam Garcia, Michael L Power, Kasey M Moyes
: Differences in macronutrients between human and ape milks appear relatively small, but variation in other components such as immunoglobulins (Ig) may be greater. This study characterized the macronutrient and secretory (sIgA) profiles in milk from gorillas and orangutans throughout lactation. Fifty-three milk samples from four gorillas and three orangutans were collected throughout 48 and 22 months postpartum (MPP), respectively. Samples were grouped in five stages of lactation (0 to 6 months, more than 6 months to 12 months, more than 12 months to 18 months, more than 18 months to 36 months, and more than 36 months to 48 months)...
March 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28115360/saccharomyces-boulardii-administration-can-inhibit-the-formation-of-gastric-lymphoid-follicles-induced-by-helicobacter-suis-infection
#8
Lin Yang, Zi-Bin Tian, Ya-Nan Yu, Cui-Ping Zhang, Xiao-Yu Li, Tao Mao, Xue Jing, Wen-Jun Zhao, Xue-Li Ding, Ruo-Ming Yang, Shuai-Qing Zhang
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces (S.) boulardii has been established as an adjunct to Helicobacter pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of Helicobacter suis and inhibited the formation of lymphoid follicles in the stomach post-infection...
January 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28066935/effects-of-corn-distillers-dried-grains-with-solubles-on-performance-oxidative-status-intestinal-immunity-and-meat-quality-of-chinese-yellow-broilers
#9
D Ruan, S Q Jiang, Y J Hu, F Y Ding, Q L Fan, F Chen, X J Lin, L Li, Y Wang
The study assessed the effects of different dietary levels of corn distillers dried grains with solubles (DDGS) on performance, oxidation status, intestinal immunity and meat quality in Chinese Yellow broilers aged from 1 to 63 days. Lingnan male hatchings (1440) were randomly assigned to six treatments, each consisting of six replicates of 40 birds. The basal diet (I) was a typical corn-soya bean ration while the experimental diets (II to VI) partially substituted corn DDGS for soya bean meal. The level of substitution in starter, grower and finisher diets was as follows: II, 2%, 4% then 6%; III, 4%, 8% then 12%; IV, 6%, 12% then 18%; V, 8%, 16% then 24%; VI, 10%, 20% then 30%...
January 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28062226/molecular-characterization-and-expression-analysis-of-three-subclasses-of-igt-in-rainbow-trout-oncorhynchus-mykiss
#10
Nu Zhang, Xu-Jie Zhang, Dan-Dan Chen, J Oriol Sunyer, Yong-An Zhang
As the teleost specific immunoglobulin, IgT plays important roles in systemic and mucosal immunity. In the current study, in rainbow trout, we have cloned the heavy chain (Igτ) genes of a secretory form of IgT2 as well as the membrane and secretory forms of a third IgT subclass, termed IgT3. Conserved cysteine and tryptophan residues that are crucial for the folding of the immunoglobulin domain as well as hydrophobic and hydrophilic residues within CART motif were identified in all IgT subclasses. Through analysis of the rainbow trout genome assembly, Igτ3 gene was found localized upstream of Igτ1 gene, while Igτ2 gene situated on another scaffold...
January 3, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28017697/anti-inflammatory-and-antioxidant-effect-of-modified-bazhengsan-in-a-rat-model-of-chronic-bacterial-prostatitis
#11
Youyi Xiong, Xingtao Qiu, Weijing Shi, Hao Yu, Xiaolin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Bazhengsan is a commonly used traditional Chinese prescription for the treatment of the urogenital system diseases for thousands of years, which decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty. AIM OF THE STUDY: In this study, the potential of modified Bazhengsan (mBazhengsan) as a chronic bacterial prostate inflammation inhibitor was investigated in a rat model. MATERIALS AND METHODS: Rat prostates were injected with Escherichia coli to induce inflammation by the sterile operation...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28008276/non-secretory-multiple-myeloma-from-biology-to-clinical-management
#12
REVIEW
Megan Murray Dupuis, Sascha A Tuchman
Multiple myeloma (MM) is the second most common hematologic malignancy in the US. It is typically characterized by production of large amounts of defective immunoglobulin (Ig). Diagnosing MM and monitoring treatment response, including eventual relapse, are largely based on sequential measurements of Ig. However, a small subset of MM called non-secretory multiple myeloma (NSMM) produces no detectable Ig. This subset of true NSMM has become even smaller over time, as the advent of the serum free light chain assay has resulted in the majority of NSMM patients being recategorized as light-chain MM - that is, MM cells that produce only the light-chain component of Ig...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27933057/glutamine-induced-secretion-of-intestinal-secretory-immunoglobulin-a-a-mechanistic-perspective
#13
REVIEW
Wenkai Ren, Kai Wang, Jie Yin, Shuai Chen, Gang Liu, Bie Tan, Guoyao Wu, Fuller W Bazer, Yuanyi Peng, Yulong Yin
Secretory immunoglobulin A (SIgA) is one important line of defense in the intestinal mucosal surface to protect the intestinal epithelium from enteric toxins and pathogenic microorganisms. Multiple factors, such as intestinal microbiota, intestinal cytokines, and nutrients are highly involved in production of SIgA in the intestine. Recently, glutamine has been shown to affect intestinal SIgA production; however, the underlying mechanism by which glutamine stimulates secretion of intestinal SIgA is unknown. Here, we review current knowledge regarding glutamine in intestinal immunity and show that glutamine-enhanced secretion of SIgA in the intestine may involve intestinal microbiota, intestinal antigen sampling and presentation, induction pathways for SIgA production by plasma cells (both T-dependent and T-independent pathway), and even transport of SIgA...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27925366/oral-administration-of-saccharomyces-boulardii-alters-duodenal-morphology-enzymatic-activity-and-cytokine-production-response-in-broiler-chickens
#14
Yajing Sun, Imran Rashid Rajput, Muhammad Asif Arain, Yanfei Li, Dost Muhammad Baloch
The present study evaluated the effects of Saccharomyces boulardii on duodenal digestive enzymes, morphology and cytokine induction response in broiler chicken. A total of 200 birds were allotted into two groups (n = 100) and each group divided into five replications (n = 20). The control group was fed basal diet in addition to antibiotic (virginiamycin 20 mg/kg), and treatment group received (1 × 10(8)  colony-forming units/kg feed) S. boulardii in addition to basal diet lasting for 72 days. The results compared to control group revealed that adenosine triphosphatase, gamma glutamyl transpeptidase, lipase and trypsin activities were higher, while, no significant improvement was observed in amylase activities in the duodenum of the treatment group...
December 7, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27921401/effects-of-soybean-isoflavone-on-intestinal-antioxidant-capacity-and-cytokines-in-young-piglets-fed-oxidized-fish-oil
#15
Lin Huang, Xian-Yong Ma, Zong-Yong Jiang, You-Jun Hu, Chun-Tian Zheng, Xue-Fen Yang, Li Wang, Kai-Guo Gao
To investigate the effect of glycitein, a synthetic soybean isoflavone (ISF), on the intestinal antioxidant capacity, morphology, and cytokine content in young piglets fed oxidized fish oil, 72 4-d-old male piglets were assigned to three treatments. The control group was fed a basal diet containing fresh fish oil, and the other two groups received the same diet except for the substitution with the same dosage of oxidized fish oil alone or with ISF (oxidized fish oil plus ISF). After 21 d of feeding, supplementation of oxidized fish oil increased the levels of malondialdehyde (MDA), oxidized glutathione (GSSG), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), nuclear factor κ B (NF-κB), inducible nitric oxide synthase (iNOS), NO, and Caspase-3 in jejunal mucosa, and decreased the villous height in duodenum and the levels of secretory immunoglobulin A (sIgA) and IL-4 in the jejunal mucosa compared with supplementation with fresh oil...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27920758/effectiveness-of-f18-fimbrial-antigens-released-by-a-novel-autolyzed-salmonella-expression-system-as-a-vaccine-candidate-against-lethal-f18-stec-infection
#16
Gayeon Won, John H Lee
Porcine edema disease (ED) caused by Shiga toxin 2e producing Escherichia coli expressing F18ab(+) fimbriae (F18ab(+)STEC) frequently occurs in post-weaned piglets, resulting in a significant economic loss in swine industries worldwide. In the present study, we proposed an efficient prevention scheme against ED in which the attenuated Salmonella Typhimurium inactivated by the E-mediated cell lysis to deliver target antigens, FedF and FedA, which function in fimbrial-mediated adhesion and as a major subunit of F18ab+fimbriae, respectively...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27911098/siga-deficiency-in-individual-small-airways-is-associated-with-persistent-inflammation-and-remodeling
#17
Vasiliy V Polosukhin, Bradley W Richmond, Rui-Hong Du, Justin M Cates, Pingsheng Wu, Hui Nian, Pierre P Massion, Lorraine B Ware, Jae Woo Lee, Alexey V Kononov, William E Lawson, Timothy S Blackwell
RATIONALE: Maintenance of a surface immune barrier is important for homeostasis in organs with mucosal surfaces that interface with the external environment; however, the role of the mucosal immune system in chronic lung diseases is incompletely understood. OBJECTIVES: We examined the relationship between secretory immunoglobulin A (SIgA) on the mucosal surface of small airways and parameters of inflammation and airway wall remodeling in chronic obstructive pulmonary disease (COPD)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27870858/first-report-of-the-occurrence-of-trichinella-specific-antibodies-in-domestic-pigs-in-central-and-eastern-uganda
#18
Kristina Roesel, Karsten Nöckler, Maximilian P O Baumann, Reinhard Fries, Michel M Dione, Peter-Henning Clausen, Delia Grace
Previous research on trichinellosis in Africa focused on isolating Trichinella from wildlife while the role of domestic pigs has remained highly under-researched. Pig keeping in Uganda is historically recent, and evidence on zoonotic pig diseases, including infection with Trichinella species, is scarce. A cross-sectional survey on Trichinella seroprevalence in pigs was conducted in three districts in Central and Eastern Uganda from April 2013 to January 2015. Serum from a random sample of 1125 pigs from 22 villages in Eastern and Central Uganda was examined to detect immunoglobulin G (IgG) against any Trichinella spp...
2016: PloS One
https://www.readbyqxmd.com/read/27857820/detection-of-specific-antibody-reactivity-to-toxocara-larval-excretory-secretory-antigens-in-asthmatic-patients-5-15-years
#19
Mahdi Mosayebi, Latif Moini, Reza Hajihossein, Mojtaba Didehdar, Zahra Eslamirad
BACKGROUND & PURPOSE: Humans act as an intermediate host for Toxocara canis and Toxocara cati. Toxocara may be an important risk factor for asthma in humans. The aim of the present study was to evaluate immunoglobulin G (IgG) anti-Toxocara canis antibody, using enzyme-linked immunosorbent assay (ELISA) in asthmatic patients (aged 5-15 years), referring to a clinic of pulmonary diseases in Arak, Iran. MATERIALS & METHODS: In this bi-group cross sectional study, serum samples were collected from 110 children with confirmed asthma and 70 children without asthma within one year...
2016: Open Microbiology Journal
https://www.readbyqxmd.com/read/27819440/self-reported-parenting-style-is-associated-with-children-s-inflammation-and-immune-activation
#20
Michelle L Byrne, Paul B Badcock, Julian G Simmons, Sarah Whittle, Adam Pettitt, Craig A Olsson, Lisa K Mundy, George C Patton, Nicholas B Allen
Family environments and parenting have been associated with inflammation and immune activation in children and adolescents; however, it remains unclear which specific aspects of parenting drive this association. In this study, we cross-sectionally examined the association between 5 discrete parenting styles and inflammation and immune activation in late childhood. Data were drawn from 102 families (55 with female children, mean age 9.50 years, SD = 0.34) participating in the Imaging Brain Development in the Childhood to Adolescence Transition Study...
November 7, 2016: Journal of Family Psychology: JFP
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