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secretory immunoglobulin a

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https://www.readbyqxmd.com/read/28525303/low-level-laser-therapy-after-wisdom-teeth-surgery-evaluation-of-immunologic-markers-secretory-immunoglobulin-a-and-lysozyme-levels-and-thermographic-examination-placebo-controlled-study
#1
Tatjana Dostalova, Veronika Kroulikova, Stepan Podzimek, Helena Jelinková
OBJECTIVE: The goal of this investigation is to analyze the effect of therapeutic low-level laser therapy (LLLT) to have a possibility to check pain and inflammation connected with surgical removal of impacted lower third molars in general anesthesia or even phobia [not accompanied by pain or fear of dental treatment, using immunologic markers-secretory immunoglobulin A (sIgA) and lysozyme]. The healing process was also monitored by infrared thermography. BACKGROUND DATA: LLLT can accelerate the proliferation phase of healing and decrease the inflammatory reaction, but the effect is not really clear...
May 16, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28504097/humoral-immune-responses-of-experimentally-eimeria-ninakholyakimovae-infected-goat-kids
#2
Lorena Matos, María Del Carmen Muñoz, José Manuel Molina, Otilia Ferrer, Francisco Rodríguez, Davinia Pérez, Adassa María López, Sergio Martín, Carlos Hermosilla, Anja Taubert, Antonio Ruiz
Although cellular immune reactions seem to be crucial for protective immune responses in Eimeria spp. infections, there are also evidences on an active involvement of the humoral counterpart. In the present study, we have analyzed the humoral response of goat kids subjected to primary and challenge infections with Eimeria ninakholyakimovae. Specific levels of IgG and IgM in serum samples and IgA in the ileal mucus were estimated. In infected kids, significantly increased levels of IgG were observed from 3 weeks post infection onwards in addition to an enhancement of specific IgM and secretory IgA levels...
April 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28496443/higher-levels-of-secretory-iga-are-associated-with-low-disease-activity-index-in-patients-with-reactive-arthritis-and-undifferentiated-spondyloarthritis
#3
Fabián Salas-Cuestas, Wilson Bautista-Molano, Juan M Bello-Gualtero, Ivonne Arias, Diana Marcela Castillo, Lorena Chila-Moreno, Rafael Valle-Oñate, Daniel Herrera, Consuelo Romero-Sánchez
INTRODUCTION: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. OBJECTIVE: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28454394/variation-and-significance-of-secretory-immunoglobulin-a-interleukin-6-and-dendritic-cells-in-oral-cancer
#4
Suxin Zhang, Xin Zhang, Ke Yin, Tianke Li, Yang Bao, Zhong Chen
The present study aimed to determine changes in the concentration of secretory immunoglobulin A (SIgA) and interleukin 6 (IL-6) in the saliva of patients with oral cancer, to evaluate the abnormal expression of cluster of differentiation (CD) 1a, CD83, CD80 and CD86 on dendritic cells (DCs) of oral cancer tissues and to discuss the interaction between SIgA, IL-6 and DCs in oral cancer. A total of 40 patients between 27 and 70 years of age, median age 52 years, with primary oral cancer were enrolled in the present study, and a group of 20 healthy male and female volunteers was used as the control group...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28439488/randomized-double-blind-placebo-controlled-parallel-group-study-of-the-effect-of-lactobacillus-paracasei-k71-intake-on-salivary-release-of-secretory-immunoglobulin-a
#5
Yuhi Saito, Mikio Fujii, Toshiyuki Watanabe, Kentaro Maruyama, Yasuyuki Kowatari, Hiromaru Ogata, Takehisa Kumagai
Lactobacillus paracasei K71 was shown to be effective in alleviating the severity of atopic dermatitis in a randomized controlled trial, and a preliminary open-label trial suggested that strain K71 intake enhanced secretory immunoglobulin A (sIgA) release in the saliva. This study investigated the effect of K71 on sIgA release in a randomized, double-blind, placebo-controlled, parallel-group trial. The trial included 62 Japanese subjects aged 20-64 years with relatively low rates of salivary sIgA release. Subjects (n=31 in each group) were randomly given a tablet containing 100 mg (approximately 2 × 10(11) bacteria) of K71 or a placebo tablet daily for 12 weeks...
2017: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/28431078/effect-of-threonine-on-secretory-immune-system-using-a-chicken-intestinal-ex%C3%A2-vivo-model-with-lipopolysaccharide-challenge
#6
Q Zhang, X Chen, S D Eicher, K M Ajuwon, T J Applegate
Secretory IgA (sIgA) and its transcytosis receptor, polymeric immunoglobulin receptor (pIgR), along with mucus, form the first lines of intestinal defense. Threonine (Thr) is a major component of intestinal mucins and IgA, which are highly secreted under lipopolysaccharide (LPS) induced inflammation. In the current study, the effect of Thr on the secretory immune system was determined in an ex vivo chicken ileal explant model. Results showed that a 2-hour Thr-deprivation of culture medium induced a compensatory increase in the mRNA expression of interleukin-8 (IL-8), mucin 2 ( ), and IgA during LPS challenge, and this increase was suppressed with Thr addition to the media ( P  ≤ 0...
April 18, 2017: Poultry Science
https://www.readbyqxmd.com/read/28394978/-salivary-immunoglobulin-a-siga-kinetics-in-young-adults-with-an-average-or-excellent-aerobic-capacity-before-and-after-a-cardiopulmonary-graded-exercise-test
#7
Paulina Yesica Ochoa-Martínez, Javier Arturo Hall-López, Marco Antonio Martínez-García, Raúl Díaz-Molina, Ana María Miranda Botelho Teixeira, José Antonio Moncada-Jiménez
BACKGROUND: Aim: To compare the concentration of secretory immunoglobulin-A (sIgA) in young adults with average or excellent aerobic capacity before and after a cardiopulmonary graded exercise test. METHODS: Participants were nine apparently healthy physically active males (Mean age = 21.3 ± 2.1 yr.), randomly allocated in two groups based on their VO2max: a) average aerobic capacity (AEC, n = 5) or b) excellent aerobic capacity (EAC, n = 4). Participants performed the Bruce protocol to determine their aerobic capacity...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28383398/effect-of-probiotics-on-digestibility-and-immunity-in-infants-a-study-protocol-for-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Lingli Xiao, Guodong Ding, Yifang Ding, Chaoming Deng, Xiaolei Ze, Liang Chen, Yao Zhang, Lihua Song, Hongli Yan, Fang Liu, Xiaoming Ben
The gastrointestinal (GI) tract of a fetus in utero is sterile but it becomes colonized with environmental microorganisms shortly after birth. Since the gut microbiota undergoes substantial changes in early life, healthy gut microflora is essential to an infant's gut health and immune system and probably also has an effect on overall health status in later life. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although randomized controlled trials using probiotics in infants have shown promising results in the prevention and treatment of common diseases such as diarrhea and allergy, little is known about whether probiotics could offer benefits to healthy infants...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28380693/a-non-chromatographic-process-for-purification-of-secretory-immunoglobulins-from-caprine-whey
#9
Alexander Matlschweiger, Gottfried Himmler, Clemens Linhart, Michael Harasek, Rainer Hahn
Secretory immunoglobulins are an important antibody class being primarily responsible for immunoprotection of mucosal surfaces. A simple, non-chromatographic purification process for secretory immunoglobulins from caprine whey was developed. In the first process step whey was concentrated 30 - 40 fold on a 500 kDa membrane, thereby increasing the purity from 3% to 15%. The second step consisted of a fractionated PEG precipitation, in which high molecular weight impurities were removed first and in the second stage the secretory immunoglobulins were precipitated, leaving a majority of the low molecular weight proteins in solution...
April 5, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28379093/single-amino-acid-substitution-in-lc-cdr1-induces-russell-body-phenotype-that-attenuates-cellular-protein-synthesis-through-eif2%C3%AE-phosphorylation-and-thereby-downregulates-igg-secretion-despite-operational-secretory-pathway-traffic
#10
Haruki Hasegawa, Ann Hsu, Christine E Tinberg, Karen E Siegler, Aaron A Nazarian, Mei-Mei Tsai
Amino acid sequence differences in the variable region of immunoglobulin (Ig) cause wide variations in secretion outputs. To address how a primary sequence difference comes to modulate immunoglobulin (Ig) secretion, we investigated the biosynthetic process of two human IgG2κ monoclonal antibodies (mAbs) that differ only by one amino acid in the light chain complementarity-determining region 1 whilst showing ∼20-fold variance in secretion titer. Although poorly secreted, the lower-secreting mAb of the two was by no means defective in terms of its folding stability, antigen binding, and in vitro biologic activity...
April 5, 2017: MAbs
https://www.readbyqxmd.com/read/28368782/yoga-stretching-for-improving-salivary-immune-function-and-mental-stress-in-middle-aged-and-older-adults
#11
Nobuhiko Eda, Hironaga Ito, Kazuhiro Shimizu, Satomi Suzuki, Eunjae Lee, Takao Akama
Protection against age-related immune suppression is important in elderly individuals. This study determined the effect of yoga on mucosal immune function and mental stress. Saliva samples were collected from 23 adult women (age: 60.4 ± 10.4 years) before and after 90 minutes of yoga stretching or rest to measure secretory immunoglobulin A (SIgA), cortisol, and testosterone. The SIgA concentration and secretion rate were significantly higher after yoga than before (p < .05). The cortisol concentration and secretion rate were lower and testosterone secretion rate higher after yoga (p < ...
April 3, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28368034/protection-of-human-colon-cells-from-shiga-toxin-by-plant-based-recombinant-secretory-iga
#12
Katsuhiro Nakanishi, Shota Morikane, Shiori Ichikawa, Kohta Kurohane, Yasuo Niwa, Yoshihiro Akimoto, Sachie Matsubara, Hayato Kawakami, Hirokazu Kobayashi, Yasuyuki Imai
Shiga toxin is a major virulence factor of food-poisoning caused by Escherichia coli such as O157:H7. Secretory immunoglobulin (Ig) A (SIgA) is supposed to prevent infection of the mucosal surface and is a candidate agent for oral immunotherapy. We previously established a recombinant monoclonal antibody (mAb) consisting of variable regions from a mouse IgG mAb specific for the binding subunit of Shiga toxin 1 (Stx1) and the Fc region of mouse IgA. Here we produced a secretory form of the recombinant IgA (S-hyIgA) with transgenic Arabidopsis thaliana plant...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341876/consumption-of-green-tea-epigallocatechin-3-gallate-enhances-systemic-immune-response-antioxidative-capacity-and-hpa-axis-functions-in-aged-male-swiss-albino-mice
#13
Rohit Sharma, Anamika Sharma, Amita Kumari, Pankaj Markand Kulurkar, Rajneesh Raj, Ashu Gulati, Yogendra S Padwad
The present investigation assessed the potential of green tea phytochemical epigallocatechin-3-gallate (EGCG) in alleviating age-associated aberrations in immunity, hypothalamus-pituitary-adrenal (HPA) axis and redox homeostasis using 16 months old male Swiss albino mice. Four groups of animals (n = 6 per group) were supplemented with either aqueous EGCG at 25, 50 and 100 mg/kg/animal or vehicle control for 6 weeks. A concurrent analysis of CD4(+) and CD8(+) lymphocytes in splenocytes, differential leucocyte population, T cell differentiation markers in peripheral blood mononuclear cells (PBMCs), neutrophil functions, immunoglobulins profile in intestine, circulatory HPA axis hormonal levels as well as inflammatory and oxidative stress in the liver was performed...
June 2017: Biogerontology
https://www.readbyqxmd.com/read/28337878/salivary-cortisol-alpha-amylase-and-immunoglobulin-a-responses-to-a-morning-session-of-basketball-or-volleyball-training-in-boys-aged-14-18-years
#14
A Bruzda-Zwiech, M Konieczka, A Hilt, M Daszkowska, J Grzegorczyk, J Szczepańska
This study investigates whether a single session of routine morning basketball or volleyball training affects saliva levels of cortisol, alpha-amylase (sAA) and secretory immunoglobulin A (sIgA) in boys aged 14–18 years. Twenty-nine boys who participate in basketball or volleyball training, recruited from the Marcin Gortat’s Athletic Championship School in Lodz, were enrolled in the study. The 90-minute routine exercise program included 15 minutes of warm-up followed by basketball or volleyball practice. Unstimulated saliva samples were collected prior to and immediately after the exercise, and were analysed using ELISA...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337225/bufei-huoxue-capsule-attenuates-pm2-5-induced-pulmonary-inflammation-in-mice
#15
Yue Jing, Hongchun Zhang, Zhe Cai, Yukun Zhao, Ye Wu, Xuan Zheng, Ying Liu, Yuying Qin, Mingjie Gu, Jin Jin
Atmospheric fine particulate matter 2.5 (PM 2.5) may carry many toxic substances on its surface and this may pose a public health threat. Epidemiological research indicates that cumulative ambient PM2.5 is correlated to morbidity and mortality due to pulmonary and cardiovascular diseases and cancer. Mitigating the toxic effects of PM2.5 is therefore highly desired. Bufei Huoxue (BFHX) capsules have been used in China to treat pulmonary heart disease (cor pulmonale). Thus, we assessed the effects of BFHX capsules on PM2...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28336271/helminth-secretomes-reflect-different-lifestyles-and-parasitized-hosts
#16
Yesid Cuesta-Astroz, Francislon Silva de Oliveira, Laila Alves Nahum, Guilherme Oliveira
Helminths cause a number of medical and agricultural problems and are a major cause of parasitic infections in humans, animals and plants. Comparative analysis of helminth genes and genomes are important to understand the genomic biodiversity and evolution of parasites and their hosts in terms of different selective pressures in their habitats. The interactions between the infective organisms and their hosts are mediated in large part by secreted proteins, known collectively as the "secretome". Proteins secreted by parasites are able to modify a host's environment and modulate their immune system...
March 21, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28325675/placental-and-colostral-transfer-of-antibodies-reactive-with-enteropathogenic-escherichia-coli-intimins-%C3%AE-%C3%AE-or-%C3%AE
#17
Silvia P N Altman, Milene Tino-De-Franco, Cristiane B Carbonare, Patricia Palmeira, Solange B Carbonare
OBJECTIVE: Intimins are protein adhesins of enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) capable of inducing attachment and effacement lesions in enterocytes. Anti-intimin antibodies are important for the protection from EPEC and EHEC infections because these antibodies inhibit bacterial adhesion and impair the initial step of the pathogenesis. We studied the transfer of maternal anti-intimin antibodies from healthy Brazilian mothers to their newborns through the placenta and colostrum...
March 19, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28317217/effects-of-a-protected-inclusion-of-organic-acids-and-essential-oils-as-antibiotic-growth-promoter-alternative-on-growth-performance-intestinal-morphology-and-gut-microflora-in-broilers
#18
Yanli Liu, Xin Yang, Hongliang Xin, Si Chen, Chengbo Yang, Yulan Duan, Xiaojun Yang
This experiment was conducted to investigate the effects of protected essential oils and organic acids mixture on poultry feeding. A total of 450 1-day-old Cobb 500 chicks were randomly allotted into three treatments with six replicates. Birds were offered a basal diet (C), basal diet with 0.15 g/kg enramycin premix (A) and basal diet with 0.30 g/kg protected essential oils and organic acids mixture product (P). The results showed that protected essential oils and organic acids mixture supplementation reduced average daily feed intake and ratio of feed to gain (F/G) at 22-42 days of age, and F/G during 1-42 days of age also declined (P < 0...
March 20, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28298536/pasteurization-procedures-for-donor-human-milk-affect-body-growth-intestinal-structure-and-resistance-against-bacterial-infections-in-preterm-pigs
#19
Yanqi Li, Duc Ninh Nguyen, Marita de Waard, Lars Christensen, Ping Zhou, Pingping Jiang, Jing Sun, Anders Miki Bojesen, Charlotte Lauridsen, Jens Lykkesfeldt, Trine Kastrup Dalsgaard, Stine Brandt Bering, Per Torp Sangild
Background: Holder pasteurization (HP) destroys multiple bioactive factors in donor human milk (DM), and UV-C irradiation (UVC) is potentially a gentler method for pasteurizing DM for preterm infants.Objective: We investigated whether UVC-treated DM improves gut maturation and resistance toward bacterial infections relative to HP-treated DM.Methods: Bacteria, selected bioactive components, and markers of antioxidant capacity were measured in unpasteurized donor milk (UP), HP-treated milk, and UVC-treated milk (all from the same DM pool)...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28263433/salivary-secretory-iga-concentration-and-dental-caries-in-children-with-down-syndrome
#20
Lina N Hashizume, Carolina Schwertner, Maurício José Santos Moreira, Adriana Simon Coitinho, Lavinia Schuler Faccini
PURPOSE: To evaluate the relationship between salivary secretory immunoglobulin A (sIgA) concentration and dental caries in children with Down syndrome (DS) and compare it with findings in non-DS children. METHODS: The sample comprised 61 DS children and 52 non-DS children, aged 6 to 14 years. Caries experience, plaque index (PI), and gingival bleeding index (GBI) were recorded. Saliva samples were collected from all children. Total salivary sIgA concentrations were determined using an enzymatic assay method...
May 2017: Special Care in Dentistry
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