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secretory immunoglobulin a

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https://www.readbyqxmd.com/read/27911098/siga-deficiency-in-individual-small-airways-is-associated-with-persistent-inflammation-and-remodeling
#1
Vasiliy V Polosukhin, Bradley W Richmond, Rui-Hong Du, Justin M Cates, Pingsheng Wu, Hui Nian, Pierre P Massion, Lorraine B Ware, Jae Woo Lee, Alexey V Kononov, William E Lawson, Timothy S Blackwell
RATIONALE: Maintenance of a surface immune barrier is important for homeostasis in organs with mucosal surfaces that interface with the external environment; however, the role of the mucosal immune system in chronic lung diseases is incompletely understood. OBJECTIVES: We examined the relationship between secretory immunoglobulin A (SIgA) on the mucosal surface of small airways and parameters of inflammation and airway wall remodeling in chronic obstructive pulmonary disease (COPD)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27870858/first-report-of-the-occurrence-of-trichinella-specific-antibodies-in-domestic-pigs-in-central-and-eastern-uganda
#2
Kristina Roesel, Karsten Nöckler, Maximilian P O Baumann, Reinhard Fries, Michel M Dione, Peter-Henning Clausen, Delia Grace
Previous research on trichinellosis in Africa focused on isolating Trichinella from wildlife while the role of domestic pigs has remained highly under-researched. Pig keeping in Uganda is historically recent, and evidence on zoonotic pig diseases, including infection with Trichinella species, is scarce. A cross-sectional survey on Trichinella seroprevalence in pigs was conducted in three districts in Central and Eastern Uganda from April 2013 to January 2015. Serum from a random sample of 1125 pigs from 22 villages in Eastern and Central Uganda was examined to detect immunoglobulin G (IgG) against any Trichinella spp...
2016: PloS One
https://www.readbyqxmd.com/read/27857820/detection-of-specific-antibody-reactivity-to-toxocara-larval-excretory-secretory-antigens-in-asthmatic-patients-5-15-years
#3
Mahdi Mosayebi, Latif Moini, Reza Hajihossein, Mojtaba Didehdar, Zahra Eslamirad
BACKGROUND & PURPOSE: Humans act as an intermediate host for Toxocara canis and Toxocara cati. Toxocara may be an important risk factor for asthma in humans. The aim of the present study was to evaluate immunoglobulin G (IgG) anti-Toxocara canis antibody, using enzyme-linked immunosorbent assay (ELISA) in asthmatic patients (aged 5-15 years), referring to a clinic of pulmonary diseases in Arak, Iran. MATERIALS & METHODS: In this bi-group cross sectional study, serum samples were collected from 110 children with confirmed asthma and 70 children without asthma within one year...
2016: Open Microbiology Journal
https://www.readbyqxmd.com/read/27819440/self-reported-parenting-style-is-associated-with-children-s-inflammation-and-immune-activation
#4
Michelle L Byrne, Paul B Badcock, Julian G Simmons, Sarah Whittle, Adam Pettitt, Craig A Olsson, Lisa K Mundy, George C Patton, Nicholas B Allen
Family environments and parenting have been associated with inflammation and immune activation in children and adolescents; however, it remains unclear which specific aspects of parenting drive this association. In this study, we cross-sectionally examined the association between 5 discrete parenting styles and inflammation and immune activation in late childhood. Data were drawn from 102 families (55 with female children, mean age 9.50 years, SD = 0.34) participating in the Imaging Brain Development in the Childhood to Adolescence Transition Study...
November 7, 2016: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/27796459/quantitation-of-human-milk-proteins-and-their-glycoforms-using-multiple-reaction-monitoring-mrm
#5
Jincui Huang, Muchena J Kailemia, Elisha Goonatilleke, Evan A Parker, Qiuting Hong, Rocchina Sabia, Jennifer T Smilowitz, J Bruce German, Carlito B Lebrilla
Human milk plays a substantial role in the child growth, development and determines their nutritional and health status. Despite the importance of the proteins and glycoproteins in human milk, very little quantitative information especially on their site-specific glycosylation is known. As more functions of milk proteins and other components continue to emerge, their fine-detailed quantitative information is becoming a key factor in milk research efforts. The present work utilizes a sensitive label-free MRM method to quantify seven milk proteins (α-lactalbumin, lactoferrin, secretory immunoglobulin A, immunoglobulin G, immunoglobulin M, α1-antitrypsin, and lysozyme) using their unique peptides while at the same time, quantifying their site-specific N-glycosylation relative to the protein abundance...
October 29, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27754716/storage-of-unfed-and-leftover-pasteurized-human-milk
#6
Ting Meng, Maryanne T Perrin, Jonathan C Allen, Jason Osborne, Frances Jones, April D Fogleman
OBJECTIVE: To determine the impact of storage on bacterial growth and immunological activity of pasteurized human milk and leftover pasteurized human milk that has been exposed to the microflora in an infant's mouth. MATERIALS AND METHODS: Eighteen mother-infant dyads participated in two separate studies. Mother's milk was pasteurized, and each baby was fed 1 to 2 ounces. Pasteurized and leftover pasteurized milk were stored at room (24°C) and refrigerated temperatures (4°C)...
October 18, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27739086/genetic-loss-of-immunoglobulin-a-does-not-influence-development-of-alcoholic-steatohepatitis-in-mice
#7
Tatsuo Inamine, An-Ming Yang, Lirui Wang, Kuei-Chuan Lee, Cristina Llorente, Bernd Schnabl
BACKGROUND: Chronic alcohol abuse is associated with intestinal dysbiosis and bacterial translocation. Translocated commensal bacteria contribute to alcoholic liver disease. Secretory immunoglobulin A (IgA) in the intestine binds bacteria and prevents bacterial translocation. METHODS: To investigate the functional role of IgA in ethanol (EtOH)-induced liver disease in mice, we subjected wild type (WT) and IgA-deficient littermate mice to Lieber-DeCarli models of chronic EtOH administration and the model of chronic and binge EtOH feeding (the NIAAA model)...
December 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27732965/nucleoside-5-o-monophosphorothioates-as-modulators-of-the-p2y14-receptor-and-mast-cell-degranulation
#8
Edyta Gendaszewska-Darmach, Edyta Węgłowska, Aurelia Walczak-Drzewiecka, Kaja Karaś
Mast cells (MCs) are long-lived resident cells known for their substantial role in antigen-induced anaphylaxis and other immunoglobulin E-mediated allergic reactions as well as tumor promotion. MCs' activation results in the release of pro-inflammatory factors such as histamine, tryptase, tumor necrosis factor or carboxypeptidase A stored in secretory granules. IgE-dependent hypersensitivity has been thought to be the major pathway mediating degranulation of mast cells, but the P2Y14 nucleotide receptor activated by UDP-glucose (UDPG) may also enhance this process...
October 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27696678/effects-of-a-progressive-muscle-relaxation-intervention-on-dementia-symptoms-activities-of-daily-living-and-immune-function-in-group-home-residents-with-dementia-in-japan
#9
Shiho Ikemata, Yumiko Momose
AIM: To evaluate the effects of progressive muscle relaxation on the behavioral and psychological symptoms of dementia, activities of daily living, and immune function of elderly patients with dementia in group homes. METHODS: The participants were ranked by their group home unit. Odd ranks were assigned to the intervention group and even ranks to the control group. The intervention group participated in progressive muscle relaxation for 15 min each day for 90 days in the group environment; the control group members continued with their normal routine...
October 3, 2016: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/27693834/effects-of-polysaccharide-from-mycelia-of-ganoderma-lucidum-on-intestinal-barrier-functions-of-rats
#10
Mingliang Jin, Yimin Zhu, Dongyan Shao, Ke Zhao, Chunlan Xu, Qi Li, Hui Yang, Qingsheng Huang, Junling Shi
The intestinal mucosal barriers play essential roles not only in the digestion and absorption of nutrients, but also the innate defense against most intestinal pathogens. In the present study, polysaccharide from the mycelia of Ganoderma lucidum was given via oral administration to rats (100mg/kg body weight, 21days) to investigate its effects on intestinal barrier functions, including the mechanical barrier, immunological barrier and biological barrier function. It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-κB p65 (NF-κB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum...
September 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27692097/secretory-immunoglobulin-a-and-immunoglobulin-g-in-horse-saliva
#11
Anna-Karin E Palm, Ove Wattle, Torbjörn Lundström, Eva Wattrang
This study aimed to increase the knowledge on salivary antibodies in the horse since these constitute an important part of the immune defence of the oral cavity. For that purpose assays to detect horse immunoglobulin A (IgA) including secretory IgA (SIgA) were set up and the molecular weights of different components of the horse IgA system were estimated. Moreover, samples from 51 clinically healthy horses were tested for total SIgA and IgG amounts in saliva and relative IgG3/5 (IgG(T)) and IgG4/7 (IgGb) content were tested in serum and saliva...
November 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27682136/effect-of-conjugated-linoleic-acid-enriched-butter-after-24-hours-of-intestinal-mucositis-induction
#12
Patrícia Aparecida Vieira de Barros, Simone de Vasconcelos Generoso, Maria Emília Rabelo Andrade, Marco Antonio Sundfeld da Gama, Fernando Cesar Ferraz Lopes, Éricka Lorenna de Sales E Souza, Flaviano Dos Santos Martins, Sued Eustáquio Mendes Miranda, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso
Mucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days...
September 28, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27661555/-the-role-of-gut-microbiota-in-the-regulation-of-the-immune-response
#13
Pedro Alarcón, Margarita González, Érica Castro
The gastrointestinal tract hosts around 10(14) bacterial microorganisms, in a constantly growing density from the stomach to the distal colon. This microbiota is composed by more than 500 species of bacteria, which are quickly acquired after birth, fairly stable during the host’s life, and essential for human homeostasis. These bacteria have important functions, such as stimulating the immune system, protecting the host from invading bacteria and viruses, and improving digestion, especially of complex carbohydrates...
July 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27661071/influence-of-ophthalmic-solutions-on-tear-components
#14
Chika Shigeyasu, Masakazu Yamada, Yoko Akune
Tear fluids are a mixture of secretions derived from lacrimal glands, accessory lacrimal glands, conjunctiva, and meibomian glands. Compositional changes to tears occur in the normal state and during ocular surface disease, such as dry eye conditions. We have investigated compositional changes to tears after topical application of ophthalmic solutions, with regard to tear-specific proteins (secretory immunoglobulin A, lactoferrin, lipocalin-1, and lysozyme) and ocular surface mucin in normal and dry eye conditions using high-performance liquid chromatography...
November 2016: Cornea
https://www.readbyqxmd.com/read/27649663/the-involvement-of-igh-enhancer-hs1-2-in-the-pathogenesis-of-crohn-s-disease-how-the-immune-system-can-influence-a-multifactorial-disease
#15
R Cianci, S Lolli, D Pagliari, G Gambassi, S Frosali, R Marmo, G Melioli, A Orlando, E E Newton, E Serone, R Landolfi, F Pandolfi, D Frezza
OBJECTIVE: To study the 3' immunoglobulin heavy-chain regulatory region (3'RR) enhancer complex, active in class switching recombination and in B-cells, in Crohn's disease. PATIENTS AND METHODS: A total of 167 patients [79 females (47.3%) and 88 males (52.7%)] affected by Crohn's disease were enrolled in the study. As a control, we included 64 healthy subjects, age and sex matched, from the same geographical area. Blood tests were performed on all subjects to determine their antibody levels and to detect the presence of any possible infections...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27644793/vacuolar-deposition-of-recombinant-proteins-in-plant-vegetative-organs-as-a-strategy-to-increase-yields
#16
Vanesa Soledad Marin Viegas, Carolina Gabriela Ocampo, Silvana Petruccelli
Delivery of recombinant proteins to vegetative tissue vacuoles was considered inconvenient since this compartment was expected to be hydrolytic; nevertheless there is growing evidence that certain foreign proteins accumulate at high yields in vacuoles. For example avidin, cellulolytic enzymes, endolysin, and transglutaminases were produced at high yields when were sorted to leaf central vacuole avoiding the detrimental effect of these proteins on plant growth. Also, several secretory mammalian proteins such as collagen, α1-proteinase inhibitor, complement-5a, interleukin-6 and immunoglobulins accumulated at higher yields in leaf vacuoles than in the apoplast or cytosol...
September 20, 2016: Bioengineered
https://www.readbyqxmd.com/read/27641915/the-microbiome-a-revolution-in-treatment-for-rheumatic-diseases
#17
REVIEW
James T Rosenbaum, Mark J Asquith
PURPOSE OF REVIEW: The microbiome is the term that describes the microbial ecosystem that cohabits an organism such as humans. The microbiome has been implicated in a long list of immune-mediated diseases which include rheumatoid arthritis, ankylosing spondylitis, and even gout. The mechanisms to account for this effect are multiple. The clinical implications from observations on the microbiome and disease are broad. RECENT FINDINGS: A growing number of microbiota constituents such as Prevotella copri, Porphyromonas gingivalis, and Collinsella have been correlated or causally related to rheumatic disease...
October 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27641057/serum-free-immunoglobulin-light-chain-fingerprint-identifies-a-subset-of-newly-diagnosed-multiple-myeloma-patients-with-worse-outcome
#18
Irit Avivi, Yael C Cohen, Erel Joffe, Noam Benyamini, Viki Held-Kuznetsov, Svetlana Trestman, Evangelos Terpos, Meletios A Dimopoulos, Efstathios Kastritis
Multiple myeloma (MM) is a multi-subclonal malignancy with relatively high heterogeneity. Patients who initially presented with both monoclonal-protein (MP) and free light chain (FLC) secretion but then relapsed with a light chain escape pattern have been shown to reflect disease clonal evolution and to bare a worse prognosis. We hypothesized that a discordant MP/FLC pattern at diagnosis may reflect a similar clonal evolution that had occurred prior to diagnosis of active myeloma, conferring a worse outcome...
September 19, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27611298/effect-of-bovine-lactoferrin-treatment-followed-by-acute-stress-on-the-iga-response-in-small-intestine-of-balb-c-mice
#19
Ma Concepción Peña-Juárez, Rafael Campos-Rodríguez, Marycarmen Godínez-Victoria, Teresita Rocío Cruz-Hernández, Humberto Reyna-Garfias, Reyna Elizabeth Barbosa-Cabrera, Maria Elisa Drago-Serrano
Secretory IgA (SIgA) has a pivotal role in gut homeostasis, which can be disturbed by stress. SIgA is formed by IgA-dimers (associated by the J-chain) and the secretory component, a protein derivative of polymeric immunoglobulin receptor (pIgR). Given the gut immuno-modulatory properties of bovine lactoferrin (bLf), the aim of this study was to compare, after bLf treatment followed by acute stress, the IgA response and IgA-associated parameters in proximal versus distal small intestine. Male BALB/c mice (n = 6) were orally treated with bLf (50, 500, and 5000 μg) for 7 days, then stressed by immobilization for 1 h, and sacrificed...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27605252/the-distribution-of-siga-and-igg-antibody-secreting-cells-in-the-palatine-tonsils-of-bactrian-camels-camelus-bactrianus-of-different-ages
#20
Shuai Jia, Wangdong Zhang, Xuefen Tan, Wanhong He, Wenhui Wang
Secretory immunoglobulin A (SIgA) antibody-secreting cells (ASCs) are the major effector cells of mucosal immunity, and immunoglobulin G (IgG) ASCs are also associated with mucosal immunity. This study aimed to explore the distribution of these 2 ASC populations in the palatine tonsils of Bactrian camels of different ages. Eighteen Bactrian camels were divided into the following three age groups: pubertal (3-5 years), middle-aged (6-16 years) and old (17-20 years). SIgA and IgG ASCs within different sites of the palatine tonsils were observed through histological and immunohistochemical techniques, and their densities were analyzed using statistical methods...
September 8, 2016: Histology and Histopathology
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