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secretory immunoglobulin a

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https://www.readbyqxmd.com/read/29774758/evaluation-of-natural-bv-as-a-novel-feed-additive-in-fast-growing-broilers
#1
Da Hye Kim, Sang Mi Han, Moung Cheul Keum, Sang Lee, Byoung Ki An, Sang-Rak Lee, Kyung-Woo Lee
1. The present study was designed to evaluate purified bee venom (BV) as an alternative to antibiotics in broiler chickens. The experimental treatment diets were formulated by adding BV into a maize-soybean meal-based diet to give 0, 10, 50, 100, and 500 μg BV per kg of diet. 2. Dietary BV quadratically improved (P<0.05) feed conversion ratio and increased body weight gain at 1-21 days as level in diet increased. Higher BV levels lowered relative weight of spleen (linear and quadratic, P<0.05), bursa of Fabricius (quadratic, P<0...
May 18, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29772785/comparison-of-human-milk-immunoglobulin-survival-during-gastric-digestion-between-preterm-and-term-infants
#2
Veronique Demers-Mathieu, Mark A Underwood, Robert L Beverly, Søren D Nielsen, David C Dallas
Human milk provides immunoglobulins (Igs) that supplement the passive immune system of neonates; however, the extent of survival of these Igs during gastric digestion and whether this differs between preterm and term infants remains unknown. Human milk, and infant gastric samples at 2 h post-ingestion were collected from 15 preterm (23⁻32 week gestational age (GA)) mother-infant pairs and from 8 term (38⁻40 week of GA) mother-infant pairs within 7⁻98 days postnatal age. Samples were analyzed via ELISA for concentration of total IgA (secretory IgA (SIgA)/IgA), total secretory component (SC/SIgA/SIgM), total IgM (SIgM/IgM), and IgG as well as peptidomics...
May 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29762161/anti-hiv-igm-protects-against-mucosal-shiv-transmission
#3
Siqi Gong, Khamis Tomusange, Viraj Kulkarni, Opeyemi S Adeniji, Samir K Lakhashe, Dinesh Hariraju, Amanda Strickland, Elizabeth Plake, Patrice A Frost, Sarah J Ratcliffe, Liping Wang, Eileen M Lafer, Ruth M Ruprecht
OBJECTIVE: Worldwide, most new HIV infections occur through mucosal exposure. Immunoglobulin M (IgM) is the first antibody class generated in response to infectious agents; IgM is present in the systemic circulation and in mucosal fluids as secretory IgM. We sought to investigate for the first time the role of IgM in preventing AIDS virus acquisition in vivo. DESIGN: Recombinant polymeric monoclonal IgM was generated from the neutralizing monoclonal IgG1 antibody 33C6-IgG1, tested in vitro, and given by passive intrarectal (i...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758053/behavior-and-physiology-of-two-different-sow-breeds-in-a-farrowing-environment-during-late-35-day-lactation
#4
Honggui Liu, Ran Yi, Chao Wang, Peng Zhao, Mingyue Zhang, Shiwen Xu, Jun Bao
To improve the overall welfare levels of sows and to reduce stress levels at late 35-day lactation, we selected targeted behavioral indicators that might be associated with stress. Therefore, we monitored and evaluated the adaptive capability of two different breeds of sows to the farrowing environment. In this study, Damin sows (Large White × Min pig sows, n = 20) and Large White sows (n = 20) were farrowed in individual pens. Saliva was collected and tested for cortisol density at -15 min, and then at +15, 30, 60, 90, 120, 180 and 240 min after an adrenocorticotropic hormone (ACTH) stimulation test conducted at 20, 27 and 34 d post-partum...
2018: PloS One
https://www.readbyqxmd.com/read/29751532/the-role-of-the-polymeric-immunoglobulin-receptor-and-secretory-immunoglobulins-during-mucosal-infection-and-immunity
#5
REVIEW
Holly Turula, Christiane E Wobus
The gastrointestinal tract houses millions of microbes, and thus has evolved several host defense mechanisms to keep them at bay, and prevent their entry into the host. One such mucosal surface defense is the secretion of secretory immunoglobulins (SIg). Secretion of SIg depends on the polymeric immunoglobulin receptor (pIgR), which transports polymeric Ig (IgA or IgM) from the basolateral surface of the epithelium to the apical side. Upon reaching the luminal side, a portion of pIgR, called secretory component (SC) is cleaved off to release Ig, forming SIg...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29705025/linking-stress-and-immunity-immunoglobulin-a-as-a-non-invasive-physiological-biomarker-in-animal-welfare-studies
#6
REVIEW
Molly Staley, Melinda G Conners, Katie Hall, Lance J Miller
As the animal welfare community strives to empirically assess how care and management practices can help maintain or even enhance welfare, the development of tools for non-invasively measuring physiological biomarkers is essential. Of the suite of physiological biomarkers, Immunoglobulin A (IgA), particularly the secretory form (Secretory IgA or SIgA), is at the forefront because of its crucial role in mucosal immunity and links to physical health, stress, and overall psychological well-being. While interpretation of SIgA values on short time scales is complex, long-term SIgA patterns are consistent: conditions that create chronic stress lead to suppression of SIgA...
April 26, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29689740/pilot-feasibility-study-to-detect-mesenchymal-stem-cell-biomarkers-of-bronchopulmonary-dysplasia-in-the-tracheal-aspirate-fluid-of-preterm-infants
#7
R G LaGrandeur, M Singhal, F Bany-Mohammed, C Uy, R Koeppel, F Zaldivar, F Haddad, A Nalbandian, P Donovan, D M Cooper, M Aslam
OBJECTIVE: This study aimed to detect novel mesenchymal stem cell peptides/biomarkers of bronchopulmonary dysplasia (BPD) in the tracheal aspirate fluid (TAF) of preterm infants. STUDY DESIGN: Participants included infants less than 32 weeks' gestational age or birth weight under 1500 grams who required endotracheal intubation and mechanical ventilation within first 24 hours of life. TAF sample collection was performed at the time of the first clinically indicated routine suctioning...
2018: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29684605/development-of-monoclonal-antibodies-against-igm-of-sea-bass-lateolabrax-japonicus-and-analysis-of-phagocytosis-by-migm-lymphocytes
#8
Shun Yang, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
B cells in some fish were recently found to have potent phagocytic activities. Sea bass (Lateolabrax japonicus) as an important economical marine fish species, it could be used as an appropriate model to study the functions of B cells in phagocytosis. In the paper, three positive hybridomas designated as 1E11, 2H4 and 3F3 secreting monoclonal antibodies (MAbs) against sea bass immunoglobulin M (IgM) were produced and used as research tools. Indirect enzyme-linked immunosorbent assay showed that all the three MAbs had a high binding capacity with sea bass serum IgM...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29660060/dietary-effects-of-bacillus-subtilis-fmbj-on-growth-performance-small-intestinal-morphology-and-its-antioxidant-capacity-of-broilers
#9
Kaiwen Bai, Chengcheng Feng, Luyi Jiang, Ligen Zhang, Jingfei Zhang, Lili Zhang, Tian Wang
This paper aimed to study the dietary effects of Bacillus subtilis fmbj (BS fmbj) on growth performance, small intestinal histomorphology, and its antioxidant capacity of broilers at 21 d of raising. A total of 300 1-d old male Arbor Acres broilers were randomly assigned to 5 groups: broilers fed the basal diets with 0 g/kg BS fmbj (CON), 0.2 g/kg BS fmbj (BS-1), 0.3 g/kg BS fmbj (BS-2), 0.4 g/kg BS fmbj (BS-3), and 0.5 g/kg BS fmbj (BS-4). The results showed that there were no differences in the growth performance among treatments during the trail...
April 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29659876/effects-of-lactobacillus-reuteri-lr1-on-the-growth-performance-intestinal-morphology-and-intestinal-barrier-function-in-weaned-pigs
#10
Hongbo Yi, Guangda Yang, Yunxia Xiong, Xiaolu Wen, Zhilin Wang, Xuefen Yang, Kaiguo Gao, Li Wang, Zongyong Jiang
The objective of this study was to investigate the effects of Lactobacillus reuteri LR1, a new strain isolated from the feces of weaned pigs, on the growth performance, intestinal morphology, immune responses, and intestinal barrier function in weaned pigs. A total of 144 weaned pigs (Duroc × Landrace × Yorkshire, 21 d of age) with an initial BW of 6.49 ± 0.02 kg were randomly assigned to 3 dietary treatments with 8 replicate pens, each of per treatment and 6 pigs. Pigs were fed a basal diet (CON, controls), the basal diet supplemented with 100 mg/kg olaquindox and 75 mg/kg aureomycin (OA) or the basal diet supplemented with 5×1010 cfu/kg L...
April 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29658063/effects-of-modified-palygorskite-supplementation-on-egg-quality-and-mineral-element-content-and-intestinal-integrity-and-barrier-function-of-laying-hens
#11
Y Su, Y P Chen, Y F Cheng, C Wen, Y M Zhou
This study was conducted to investigate effects of modified palygorskite (MPal) supplementation on the laying performance, egg quality and mineral element content, immunity, oxidative status, and intestinal integrity and barrier function of laying hens. A total of 360 52-week-old Hyline Brown hens were randomly assigned into four dietary treatments for a 7-week feeding trial. The birds were fed a basal diet supplemented with 0 (control group), 0.25, 0.5, and 1 g/kg MPal, respectively. The supplementation of MPal did not alter laying performance and egg quality among groups...
April 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29650518/secretory-igm-exacerbates-tumor-progression-by-inducing-accumulations-of-mdscs-in-mice
#12
Chih-Hang Anthony Tang, Shiun Chang, Ayumi Hashimoto, Yi-Ju Chen, Chang Won Kang, Anthony R Mato, Juan R Del Valle, Dmitry Gabrilovich, Chih-Chi Andrew Hu
Chronic lymphocytic leukemia cells can secrete immunoglobulin M. However, it is not clear whether secretory IgM (sIgM) plays a role in disease progression. We crossed the Eμ-TCL1 mouse model of CLL, in which the expression of human TCL1 oncogene was driven by the V(H) promoter-Ig(H)-Eμ enhancer, with MD4 mice whose B cells produced B cell receptor (membrane-bound IgM) and sIgM with specificity for hen egg lysozyme (HEL). CLL cells developed in these MD4/Eμ-TCL1 mice reactivated a parental Ig gene allele and secreted IgM, and did not recognize HEL...
April 12, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29627864/exercise-intensity-and-its-impact-on-relationships-between-salivary-immunoglobulin-a-saliva-flow-rate-and-plasma-cortisol-concentration
#13
Christof A Leicht, Victoria L Goosey-Tolfrey, Nicolette C Bishop
INTRODUCTION: Salivary secretory immunoglobulin A (sIgA), saliva flow rate and plasma cortisol concentrations have been shown to be influenced by exercise, particularly the intensity exercise is performed at, and circadian variation. The autonomic nervous system partly regulates salivary secretion, but it is not yet known whether cortisol also explains some variation in salivary parameters. METHODS: Twelve moderately trained male individuals ([Formula: see text]peak legs : 46...
April 7, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29626602/protective-properties-of-combined-fungal-polysaccharides-from-cordyceps-sinensis-and-ganoderma-atrum-on-colon-immune-dysfunction
#14
Song-Tao Fan, Shao-Ping Nie, Xiao-Jun Huang, Sunan Wang, Jie-Lun Hu, Jun-Hua Xie, Qi-Xing Nie, Ming-Yong Xie
In vivo an ecological network of polysaccharides utilization by gut microbiota is not only an intense competition but also an impressive cooperation pattern. The present study evaluated the in vivo protective effect of combined fungal polysaccharides (CFP) from Cordyceps sinensis and Ganoderma atrum on colon immune dysfunction, induced by 150 mg/kg cyclophosphamide (CP). The results showed that C. sinensis polysaccharides (CSP) significantly promoted microbial-derived butyrate to improve histone h3 acetylation mediating regulatory T (Treg) cell specific Foxp3, as well as significantly restored CP-induced elevation of interleukin (IL)-17 and IL-21...
April 4, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29597003/prenatal-and-postnatal-cigarette-and-cannabis-exposure-effects-on-secretory-immunoglobulin-a-in-early-childhood
#15
Danielle S Molnar, Douglas A Granger, Shannon Shisler, Rina D Eiden
AIMS: Secretory Immunoglobulin A (SIgA) plays a critical role in immune functioning by preventing pathogens from adhering to epithelial mucosa. Most infectious agents enter the body via mucosal surfaces, thus SIgA serves in the defense against respiratory, intestinal, and urinogenitary infections, as well as periodontal disease and caries. This study examined the possibility that pre- and postnatal exposure to cigarette and cannabis is associated with individual differences in Secretory Immunoglobulin A (SIgA) levels in early childhood...
March 26, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29567956/the-molecular-mechanism-for-activating-iga-production-by-pediococcus-acidilactici-k15-and-the-clinical-impact-in-a-randomized-trial
#16
Tadaomi Kawashima, Naho Ikari, Tomoko Kouchi, Yasuyuki Kowatari, Yoshiro Kubota, Naoki Shimojo, Noriko M Tsuji
IgA secretion at mucosal sites is important for host defence against pathogens as well as maintaining the symbiosis with microorganisms present in the small intestine that affect IgA production. In the present study, we tested the ability of 5 strains of lactic acid bacteria stimulating IgA production, being Pediococcus acidilactici K15 selected as the most effective on inducing this protective immunoglobulin. We found that this response was mainly induced via IL-10, as efficiently as IL-6, secreted by K15-stimulated dendritic cells...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29546302/theobromine-is-responsible-for-the-effects-of-cocoa-on-the-antibody-immune-status-of-rats
#17
Mariona Camps-Bossacoma, Francisco J Pérez-Cano, Àngels Franch, Margarida Castell
Background: A 10% cocoa-enriched diet influences immune system functionality including the prevention of the antibody response and the induction of lower immunoglobulin (Ig) concentrations. However, neither cocoa polyphenols nor cocoa fiber can totally explain these immunoregulatory properties. Objectives: This study aimed to establish the influence of cocoa theobromine in systemic and intestinal Ig concentrations and to determine the effect of cocoa or theobromine feeding on lymphoid tissue lymphocyte composition...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29498209/an-ice-binding-and-tandem-beta-sandwich-domain-containing-protein-in-shewanella-frigidimarina-is-a-potential-new-type-of-ice-adhesin
#18
Tyler D R Vance, Laurie A Graham, Peter L Davies
Out of the dozen different ice-binding protein (IBP) structures known, the DUF3494 domain is the most widespread, having been passed many times between prokaryotic and eukaryotic microorganisms by horizontal gene transfer. This ~25-kDa β-solenoid domain with an adjacent parallel α-helix is most commonly associated with an N-terminal secretory signal peptide. However, examples of the DUF3494 domain preceded by tandem Bacterial Immunoglobulin-like (BIg) domains are sometimes found, though uncharacterized. Here, we present one such protein (SfIBP_1) from the Antarctic bacterium Shewanella frigidimarina...
April 2018: FEBS Journal
https://www.readbyqxmd.com/read/29489723/upper-respiratory-tract-infection-and-mucosal-immunity-in-young-ice-hockey-players-during-the-pre-tournament-training-period
#19
Joanna Orysiak, Konrad Witek, Jadwiga Malczewska-Lenczowska, Agnieszka Zembron-Lacny, Andrzej Pokrywka, Dariusz Sitkowski
The aim of this study was to determine the effects of 17 days of training during preparation for the Ice Hockey Under 18 World Championship of the Polish ice hockey national team on the mucosal immune function and monitor upper respiratory tract infection (URTI) incidence before, during and after the competition. Twelve male ice hockey players (age 17.7±0.5 years) were recruited for this study. The first saliva/blood collection took place at the beginning of the training camp (without training at the training camp), the second one was conducted on the 9th day of the training camp immediately after the intensification of training, and the third collection was carried out on the 13th day of training (4 days before leaving for the World Championship) in the tapering phase...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29477386/visualisation-of-intracellular-production-bottlenecks-in-suspension-adapted-cho-cells-producing-complex-biopharmaceuticals-using-fluorescence-microscopy
#20
Sven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz, Harald Bradl, Ingo Gorr, Martin Gamer, Kerstin Otte
With the advance of complex biological formats such as bispecific antibodies or fusion proteins, mammalian expression systems often show low performance. Described determining factors may be accumulation or haltering of heterologous proteins within the different cellular compartments disturbing transport or secretion. In case of the investigated bispecific antibody (bsAb)-producing Chinese hamster ovary (CHO) cell line neither impaired transcription nor decreased translation processes were identified and thus satisfactorily explained its low production capacity...
April 10, 2018: Journal of Biotechnology
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