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https://www.readbyqxmd.com/read/29333822/labial-adhesions-experience-in-a-children-s-hospital
#1
Anahí Rubinstein, Gisel Rahman, Paula Risso, Dolores Ocampo
Labial adhesions are defined as the complete or partial fusion of the pudendal cleft due to the agglutination of the labia minora in the midline. They most commonly occur between 3 months and 6 years of life. Between January 1st, 2002 and December 31st, 2015, 425 girls diagnosed with labial adhesions and seen at the Unit of Pediatric and Adolescent Gynecology of Hospital de Niños de La Plata, Argentina, were analyzed. Their average age was 2.7 years (standard deviation: 2.6 years). The most common presentation of labial adhesions was that involving more than 75% of the total length of the labia (p < 0...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29331876/app-go-protein-g%C3%AE-%C3%AE-complex-signaling-mediates-a%C3%AE-degeneration-and-cognitive-impairment-in-alzheimer-s-disease-models
#2
Elena Anahi Bignante, Nicolás Eric Ponce, Florencia Heredia, Juliana Musso, María C Krawczyk, Julieta Millán, Gustavo F Pigino, Nibaldo C Inestrosa, Mariano M Boccia, Alfredo Lorenzo
Deposition of amyloid-β (Aβ), the proteolytic product of the amyloid precursor protein (APP), might cause neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the direct involvement of APP in the mechanism of Aβ-induced degeneration in AD remains on debate. Here, we analyzed the interaction of APP with heterotrimeric Go protein in primary hippocampal cultures and found that Aβ deposition dramatically enhanced APP-Go protein interaction in dystrophic neurites. APP overexpression rendered neurons vulnerable to Aβ toxicity by a mechanism that required Go-Gβγ complex signaling and p38-mitogen-activated protein kinase activation...
December 20, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29319890/two-novel-unstable-hemoglobin-variants-due-to-in-frame-deletions-of-key-amino-acids-in-the-%C3%AE-globin-chain
#3
Karen Gabriela Scheps, Marcia Anahí Hasenahuer, Gustavo Parisi, Héctor M Targovnik, Eliana García, Ernesto Samuel Veber, Renée Crisp, Graciela Elena, Viviana Varela, María Silvina Fornasari
Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-frame deletions, leading to β-globin variants in pediatric patients in Argentina. The HBB gene of the probands and their parents was sequenced, and other markers of globin chain imbalance were analyzed...
January 10, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29315129/relative-contributions-of-adductor-canal-block-and-intrathecal-morphine-to-analgesia-and-functional-recovery-after-total-knee-arthroplasty-a-randomized-controlled-trial
#4
Abhijit Biswas, Anahi Perlas, Meela Ghosh, KiJinn Chin, Ahtsham Niazi, Barjind Pandher, Vincent Chan
BACKGROUND AND OBJECTIVES: Effective postoperative analgesia may enhance early rehabilitation after orthopedic surgery. This randomized double-blind trial investigates the relative contributions of adductor canal block and low-dose intrathecal morphine (ITM) to postoperative analgesia and functional recovery after total knee arthroplasty. METHODS: Two-hundred one patients undergoing elective unilateral total knee arthroplasty under spinal anesthesia were randomized to 3 groups...
January 9, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29277116/trixis-angustifolia-hexanic-extract-displays-%C3%A2-synergistic-antibacterial-activity-against-m-tuberculosis
#5
Anahí C Sánchez-Chávez, Anuar Salazar-Gómez, L Gerardo Zepeda-Vallejo, María de L Hernández de Jesús, Manuel Quintos-Escalante, Ma Elena Vargas-Díaz, Julieta Luna-Herrera
A phytochemical and antibacterial study of Trixis angustifolia, a species endemic to Mexico, was performed allowing the isolation of six flavones. The minimal inhibitory concentration (MIC) of the hexanic extract, against Mycobacterium tuberculosis H37Rv was 25 μg/mL. The hexanic extract caused a significant inhibition of intracellular mycobacterial growth at 12.5 μg/mL. The biodirected assay of hexane extract enabled the detection of an active fraction (AF) against M. tuberculosis (MIC = 12.5 μg/mL), and a major flavone 1 (pebrellin) with no antimycobacterial activity (MIC > 200 μg/mL)...
December 25, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29259986/apoptotic-signaling-pathways-in-glioblastoma-and-therapeutic-implications
#6
REVIEW
Silvia Anahi Valdés-Rives, Diana Casique-Aguirre, Liliana Germán-Castelán, Marco A Velasco-Velázquez, Aliesha González-Arenas
Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.
2017: BioMed Research International
https://www.readbyqxmd.com/read/29242585/risks-to-pollinators-and-pollination-from-invasive-alien-species
#7
REVIEW
Adam J Vanbergen, Anahí Espíndola, Marcelo A Aizen
Invasive alien species modify pollinator biodiversity and the services they provide that underpin ecosystem function and human well-being. Building on the Intergovernmental Science-Policy Platform for Biodiversity and Ecosystem Services (IPBES) global assessment of pollinators and pollination, we synthesize current understanding of invasive alien impacts on pollinators and pollination. Invasive alien species create risks and opportunities for pollinator nutrition, re-organize species interactions to affect native pollination and community stability, and spread and select for virulent diseases...
January 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29237780/early-inhibition-of-fatty-acid-synthesis-reduces-generation-of-memory-precursor-effector-t-cells-in-chronic-infection
#8
Samad A Ibitokou, Brian E Dillon, Mala Sinha, Bartosz Szczesny, Añahi Delgadillo, Doaa Reda Abdelrahman, Csaba Szabo, Lutfi Abu-Elheiga, Craig Porter, Demidmaa Tuvdendorj, Robin Stephens
Understanding the mechanisms of CD4 memory T cell (Tmem) differentiation in malaria is critical for vaccine development. However, the metabolic regulation of CD4 Tmem differentiation is not clear, particularly in persistent infections. In this study, we investigated the role of fatty acid synthesis (FAS) in Tmem development in Plasmodium chabaudi chronic mouse malaria infection. We show that T cell-specific deletion and early pharmaceutical inhibition of acetyl CoA carboxylase 1, the rate limiting step of FAS, inhibit generation of early memory precursor effector T cells (MPEC)...
December 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29232534/detection-of-dengue-virus-in-bat-flies-diptera-streblidae-of-common-vampire-bats-desmodus-rotundus-in-progreso-hidalgo-mexico
#9
Judith Abundes-Gallegos, Monica Salas-Rojas, Guillermo Galvez-Romero, Leonardo Perea-Martínez, Cirani Y Obregón-Morales, Juan B Morales-Malacara, Bruno B Chomel, Matthew J Stuckey, Hayde Moreno-Sandoval, Anahi García-Baltazar, Benjamin Nogueda-Torres, Gerardo Zuñiga, Alvaro Aguilar-Setién
Blood-feeding arthropods play a major role in the transmission of several flaviviruses, which represent an important problem for human health. Currently, dengue is one of the most important arboviral emerging diseases worldwide. Furthermore, some previous studies have reported the presence of viral nucleic acids and antibodies against dengue virus (DENV) in wild animals. Our knowledge of the role played by wildlife reservoirs in the sylvatic transmission and maintenance of DENV remains limited. Our objective was to screen blood-feeding ectoparasites (bat flies) and their common vampire bat (Desmodus rotundus) hosts, for flaviviruses in Hidalgo, Mexico...
December 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29230709/point-of-care-gastric-ultrasound-and-aspiration-risk-assessment-a-narrative-review
#10
Anahi Perlas, Cristian Arzola, Peter Van de Putte
This narrative review summarizes the current knowledge on point-of-care ultrasound (POCUS) of gastric contents in order to inform an assessment of aspiration risk and guide anesthetic management at the bedside. An I-AIM framework (Indication, Acquisition, Interpretation, and Medical decision-making) is used to summarize and organize the content areas. This narrative review spans the breadth of the literature on pediatric and adult subjects as well as on special patient populations such as obstetric and severely obese individuals...
December 11, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29228029/pockets-as-structural-descriptors-of-egfr-kinase-conformations
#11
Marcia Anahi Hasenahuer, German Patricio Barletta, Sebastián Fernandez-Alberti, Gustavo Parisi, María Silvina Fornasari
Epidermal Growth Factor Receptor (EGFR), a tyrosine kinase receptor, is one of the main tumor markers in different types of cancers. The kinase native state is mainly composed of two populations of conformers: active and inactive. Several sequence variations in EGFR kinase region promote the differential enrichment of conformers with higher activity. Some structural characteristics have been proposed to differentiate kinase conformations, but these considerations could lead to ambiguous classifications. We present a structural characterisation of EGFR kinase conformers, focused on active site pocket comparisons, and the mapping of known pathological sequence variations...
2017: PloS One
https://www.readbyqxmd.com/read/29206761/skeletal-muscle-mitochondrial-function-is-determined-by-burn-severity-sex-and-sepsis-and-is-associated-with-glucose-metabolism-and-functional-capacity-in-burned-children
#12
Victoria G Rontoyanni, Ioannis Malagaris, David N Herndon, Eric Rivas, Karel D Capek, Anahi D Delgadillo, Nisha Bhattarai, Armando Elizondo, Charles D Voigt, Celeste C Finnerty, Oscar E Suman, Craig Porter
BACKGROUND: Restoring normal mitochondrial function represents a new target for strategies aimed at mitigating the stress response to severe burn trauma and hastening recovery. Our objective was to investigate the determinants of skeletal muscle mitochondrial respiratory capacity and function and its association with glucose metabolism and functional capacity in burned children. METHODS: Data from burned children enrolled in the placebo arm of an ongoing prospective clinical trial were analyzed...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29152936/gastric-ultrasound-to-guide-anesthetic-management-in-elective-surgical-patients-non-compliant-with-fasting-instructions-a-retrospective-cohort-study
#13
Peter van de Putte, Jonathan van Hoonacker, Anahi Perlas
BACKGROUND: Perioperative aspiration leads to significant morbidity and mortality. Standard fasting periods are used to ensure an empty stomach in patients. Anesthesiologists are frequently confronted with cases of dubious adherence to these guidelines. Point-of-care gastric ultrasound is a diagnostic tool that offers information on the type and volume of gastric contents. METHODS: We performed a retrospective analysis of a departmental database containing clinical and sonographic information on elective surgical patients who had been non- compliant to the fasting guidelines...
November 17, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29121591/proteomic-and-enzymatic-response-under-cr-vi-overload-in-yeast-isolated-from-textile-dye-industry-effluent
#14
Verónica Irazusta, Anahí Romina Bernal, María Cristina Estévez, Lucía I C de Figueroa
Cyberlindnera jadinii M9 and Wickerhamomyces anomalus M10 isolated from textile-dye liquid effluents has shown capacity for chromium detoxification via Cr(VI) biological reduction. The aim of the study was to evaluate the effect of hexavalent chromium on synthesis of novel and/or specific proteins involved in chromium tolerance and reduction in response to chromium overload in two indigenous yeasts. A study was carried out following a proteomic approach with W. anomalus M10 and Cy. jadinii M9 strains. For this, proteins extracts belonging to total cell extracts, membranes and mitochondria were analyzed...
November 6, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29099114/d%C3%A3-pteros-ectopar%C3%A3-sitos-hemat%C3%A3-fagos-%C3%A2-reservorios-potenciales-del-virus-del-dengue
#15
Álvaro Aguilar Setién, Anahí García Baltazar, Ignacio Olave Leyva, Mónica Salas Rojas, Vadim Pérez Koldenkova, Mariem Pérez-Peña García, Nidia Aréchiga Ceballos, Guillermo Gálvez Romero, Edgar Olivier López Villegas, Juan Bibiano Morales Malacara, Cenia Almazán Marín
Recently, the presence of antibodies and dengue virus (DV) RNA in neotropical wild mammals, including Desmodus rotundus, was reported. In a previous study, DV was also found in a high percentage (39.6%) of ectoparasitic hematophagous dipters specifics of these hematophagous bats. In order to verify the susceptibility of these ectoparasites to DV, in this work experimental infections with VD2 of organs explants of Strebla wiedemanni and of Melophagus ovinus were performed using C6/36 cells as control. Viral titers (UFP/mL) were determined at 0, 48 and 96 hrs pi...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28994615/mtrr-a66g-rfc1-g80a-and-mthfr-c677t-and-a1298c-polymorphisms-and-disease-activity-in-mexicans-with-rheumatoid-arthritis-treated-with-methotrexate
#16
Mirna Gisel González-Mercado, Fernando Rivas, M Patricia Gallegos-Arreola, M Cristina Morán-Moguel, Mario Salazar-Páramo, Laura González-López, J Iván Gámez-Nava, J Francisco Muñoz-Valle, Ricardo Medina-Coss Y León, Anahí González-Mercado, Mario A Aceves, Nory O Dávalos, Agustín Macías-Chumacera, Ingrid P Dávalos
AIM: To investigate the relationships of polymorphisms in genes whose protein products are related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C, and disease activity in Mexican patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). MATERIALS AND METHODS: Sixty-eight patients with RA were included in the study who were being treated with MTX, either with or without other drugs. In addition to general data, disease activity was measured by the disease activity score 28 (DAS28)...
November 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28985178/sarcoidosis-mimicking-lytic-osseous-metastases
#17
Anahy M Brandy-García, Ivan Cabezas-Rodriguez, Luis Caminal-Montero, Carlos Suarez-Cuervo, Pilar Redondo-Buil
No abstract text is available yet for this article.
October 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28967042/a-systematic-review-of-leptospirosis-on-wild-animals-in-latin-america
#18
REVIEW
Anahi S Vieira, Priscila S Pinto, Walter Lilenbaum
Leptospirosis is a bacterial systemic infection which affects domestic animals and wildlife, as well as humans. Many wild animals act as reservoirs of leptospires. Nevertheless, the real role of wildlife animals as source of infection to livestock and humans, as well as the most important reservoirs and leptospiral strains remains unclear. This systematic review assesses the available data about wildlife and their biomes in Latin America, concerning to leptospiral infection. In addition, we discuss the development of the research on leptospirosis in wildlife in this region...
October 1, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28918600/morphology-and-size-of-blood-cells-of-rhinella-arenarum-hensel-1867-as-environmental-health-assessment-in-disturbed-aquatic-ecosystem-from-central-argentina
#19
Zulma Anahí Salinas, Mariana Baraquet, Pablo Raúl Grenat, Adolfo Ludovico Martino, Nancy Edith Salas
Four populations of Rhinella arenarum from aquatic environments with different degrees of disturbance in central Argentina were compared to assess the ability of cytomorphology and cytomorphometry of blood cells as a hematological biomarker. A total of 93 specimens of R. arenarum (adults sexually mature) were captured during the spring. From the analysis of cell, no variations were found in terms of morphology, whereas in nuclear and cell areas and Price-Jones curves, we observed a smaller size in erythrocytes of individuals inhabiting the site most altered, "Villa Dalcar," as well as for leukocytes, lymphocytes, neutrophils, and eosinophils for the same site...
November 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28860245/draft-genome-sequence-of-the-phytopathogenic-fungus-fusarium-euwallaceae-the-causal-agent-of-fusarium-dieback
#20
Enrique Ibarra-Laclette, Diana Sánchez-Rangel, Eric Hernández-Domínguez, Claudia-Anahí Pérez-Torres, Randy Ortiz-Castro, Emanuel Villafán, Alexandro Alonso-Sánchez, Benjamín Rodríguez-Haas, Abel López-Buenfil, Clemente García-Avila, José-Abrahán Ramírez-Pool
Here, we report the genome of Fusarium euwallaceae strain HFEW-16-IV-019, an isolate obtained from Kuroshio shot hole borer (a Euwallacea sp.). These beetles were collected in Tijuana, Mexico, from elm trees showing typical symptoms of Fusarium dieback. The final assembly consists of 287 scaffolds spanning 48,274,071 bp and 13,777 genes.
August 31, 2017: Genome Announcements
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