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https://www.readbyqxmd.com/read/28814245/benefits-of-sglt2-inhibitors-beyond-glycemic-control-a-focus-on-metabolic-cardiovascular-and-renal-outcomes
#1
Molly G Minze, Kayley Will, Brian T Terrell, Robin L Black, Brian K Irons
BACKGROUND: Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new pharmacotherapeutic class for the treatment of type 2 diabetes mellitus (T2DM). OBJECTIVE: To evaluate beneficial effects of the SGLT2 inhibitors on metabolic, cardiovascular, and renal outcomes. METHODS: A Pub-Med search (1966 to July 2017) was performed of published English articles using keywords sodium-glucose co-transporter 2 inhibitors, canagliflozin, dapagliflozin, and empagliflozin...
August 16, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28806822/-multiple-myeloma-current-status-in-diagnostic-testing-and-therapy
#2
Michael Kehrer, Sebastian Koob, Andreas Strauss, Dieter Christian Wirtz, Jan Schmolders
Background Multiple myeloma is a haematological blood cancer of the bone marrow and is classified by the World Health Organisation (WHO) as a plasma cell neoplasm. In multiple myeloma, normal plasma cells transform into malignant myeloma cells and produce large quantities of an abnormal immunoglobulin called monoclonal protein or M protein. This ultimately causes multiple myeloma symptoms such as bone damage or kidney problems. The annual worldwide incidence of multiple myeloma is estimated to be 6 - 7/100,000 and accounts for 1% of all cancer...
August 14, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28800057/experiences-of-gynecological-cancer-patients-receiving-care-from-specialist-nurses-a-qualitative-systematic-review
#3
Olivia Cook, Meredith McIntyre, Katrina Recoche, Susan Lee
BACKGROUND: The care needs of women with gynecological cancer are complex and change over the course of their cancer journey. Specialist nurses are well positioned to play a role in meeting the needs of women with gynecological cancer although their role and scope of practice have not been well defined. As patients are a key stakeholder, understanding their experience of care is an important step in better defining the role and scope of practice of specialist nurses in gynecological oncology in Australia and New Zealand...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28799854/proteomic-studies-in-the-discovery-of-cerebrospinal-fluid-biomarkers-for-amyotrophic-lateral-sclerosis
#4
Peggy Barschke, Patrick Oeckl, Petra Steinacker, Albert Ludolph, Markus Otto
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative motor neuron disease, which usually leads to death within a few years. The diagnosis is mainly based on clinical symptoms and there is a need for ALS-specific biomarkers to make an early and precise diagnosis, for development of disease-modifying drugs and to gain new insights into pathophysiology. Areas covered: In the present review, we summarize studies using mass spectrometric (MS) approaches to identify protein alterations in the cerebrospinal fluid (CSF) of ALS patients...
August 14, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28794585/current-status-of-robotic-single-port-surgery
#5
REVIEW
Ryan J Nelson, Jaya Sai S Chavali, Nitin Yerram, Paurush Babbar, Jihad H Kaouk
Robotic-assisted laparoscopic surgery in urology is an ever progressing field, and boundaries are constantly broken with the aid of new technology. Advancements in instrumentation have given birth to the era of robotic laparoendoscopic single-site technique (R-LESS). R-LESS however, has not gained widespread acceptance due to technical hurdles such as adequate triangulation, robotic arm clashing, decreased access for the bedside assistant, lack of wrist articulation, continued need for an axillary/accessory port, lack of robust retraction, and ergonomic discomfort...
July 2017: Urology Annals
https://www.readbyqxmd.com/read/28763184/-smartphone-use-in-nursing-population-a-narrative-review
#6
Gianluca Pucciarelli, Silvio Simeone, Giuseppe Madonna, Michele Virgolesi
INTRODUCTION: In healthcare, smartphone is becoming an important tool among nursing population. With the smartphones, it was possible to implement new care models. However, if used incorrectly, it could be the cause of nurses' distraction and nosocomial infection. AIM: To analyze the various apps used by the nursing population and describe the smartphones' positive and negative aspects on health care by review the literature. METHOD: PubMed, CINAHL, SCOPUS e Web of Knowledge, Google Schoolar, databases were used to perform this study...
April 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28761630/s100-b-a-new-concept-in-neurocritical-care
#7
REVIEW
Omidvar Rezaei, Hossein Pakdaman, Kurosh Gharehgozli, Leila Simani, Amir Vahedian-Azimi, Sina Asaadi, Zahra Sahraei, Mohammadreza Hajiesmaeili
After brain injuries, concentrations of some brain markers such as S100B protein in serum and cerebrospinal fluid (CSF) are correlated with the severity and outcome of brain damage. To perform an updated review of S100B roles in human neurocritical care domain, an electronic literature search was carried among articles published in English prior to March 2017. They were retrieved from PubMed, Scopus, EMBSCO, CINAHL, ISC and the Cochrane Library using keywords including "brain", "neurobiochemical marker", "neurocritical care", and "S100B protein"...
April 4, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28754582/catatonia-in-children-and-adolescents-new-perspectives
#8
Xavier Benarous, Marie Raffin, Vladimir Ferrafiat, Angèle Consoli, David Cohen
INTRODUCTION: Catatonia is a rare and severe psychomotor condition in children and adolescents. In the current report, we aimed to review the recent literature. METHOD: Using a PRISMA approach, we searched MEDLINE between 1982 and 2017 using the keywords 'CATATONIA' and 'CHILD' or 'ADOLESCENT'. In total, we reviewed 130 reports (controlled study, N=4; clinical chart, N=23; case report, N=54; and editorial/review, N=42). RESULTS: Several aspects seem to be age specific: (1) although the clinical presentation resembles that in adults, some symptoms are important in children and adolescents (e...
July 25, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28748861/current-evidences-for-the-use-of-uescope-in-airway-management
#9
REVIEW
Fu-Shan Xue, Ben-Quan Yang, Ya-Yang Liu, Hui-Xian Li, Gui-Zhen Yang
OBJECTIVE: UEscope is a new angulated videolaryngoscope (VL). This review aimed to describe the features of UEscope and provide clinical evidences regarding the efficacy and safety of this video device in adult tracheal intubation and its roles in airway management teaching. DATA SOURCES: The Wan Fang Data, CNKI, PubMed, Embase, Cochrane Library, and Google Scholar were searched for relevant English and Chinese articles published up to January 15, 2017, using the following keywords: "HC video laryngoscope", "UE videolaryngoscope", "video laryngoscope", and "videolaryngoscopy"...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28746534/brazilian-guidelines-for-the-diagnosis-and-treatment-of-cystic-fibrosis
#10
Rodrigo Abensur Athanazio, Luiz Vicente Ribeiro Ferreira da Silva Filho, Alberto Andrade Vergara, Antônio Fernando Ribeiro, Carlos Antônio Riedi, Elenara da Fonseca Andrade Procianoy, Fabíola Villac Adde, Francisco José Caldeira Reis, José Dirceu Ribeiro, Lídia Alice Torres, Marcelo Bicalho de Fuccio, Matias Epifanio, Mônica de Cássia Firmida, Neiva Damaceno, Norberto Ludwig-Neto, Paulo José Cauduro Maróstica, Samia Zahi Rached, Suzana Fonseca de Oliveira Melo
Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease...
May 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28742290/infant-related-intrusive-thoughts-of-harm-in-the-postpartum-period-a-critical-review
#11
Elke C Brok, Patricia Lok, Desiree B Oosterbaan, Aart H Schene, Indira Tendolkar, Philip F van Eijndhoven
BACKGROUND: Besides the expected warm and joyful thoughts, a new mother can be disturbed by sudden frightening thoughts or images of harm done to her baby: harming intrusions, an obsessive phenomenon. Its high prevalence and possible consequences in functioning and in mother-child bonding makes it desirable that clinicians are well informed regarding the current state of knowledge about harming intrusions. OBJECTIVE: To provide a comprehensive review of all studies that have investigated harming intrusions in postpartum women...
July 18, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28730285/an-update-on-implants-for-minimally-invasive-glaucoma-surgery-migs
#12
REVIEW
Ejaz Ansari
For several years, the gold standard for surgical treatment of glaucoma has been trabeculectomy. Although very successful at reducing intraocular pressure (IOP), there are several potential complications of trabeculectomy, including sight-threatening ones. This has stimulated much research aimed at the development of new and effective procedures to lower IOP with an enhanced safety profile. Minimally invasive glaucoma surgery (MIGS) procedures prioritise patient safety but also demonstrate efficacy in reducing IOP...
July 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28729846/what-s-new-in-addiction-prevention-in-young-people-a-literature-review-of-the-last-years-of-research
#13
REVIEW
Cédric Kempf, Pierre-Michel Llorca, Frank Pizon, Georges Brousse, Valentin Flaudias
Rationale: Addiction prevention is a major public health problem, particularly concerning young people. Despite the consensus that primary prevention is essential, the evaluation of its impact is questioned. Objective: The objective of this paper is to assess the latest knowledge of addiction prevention programs for young people. Method: Review a collection of research articles using a keyword-based search on three databases: Pubmed, Eric, and PsycInfo. The research was carried out using three groups of keywords and the eligibility study was completed using two criteria: articles published between 2010 and 2017, and articles in refereed journals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28729235/improving-adherence-to-web-based-and-mobile-technologies-for-people-with-psychosis-systematic-review-of-new-potential-predictors-of-adherence
#14
Clare Killikelly, Zhimin He, Clare Reeder, Til Wykes
BACKGROUND: Despite the boom in new technologically based interventions for people with psychosis, recent studies suggest medium to low rates of adherence to these types of interventions. The benefits will be limited if only a minority of service users adhere and engage; if specific predictors of adherence can be identified then technologies can be adapted to increase the service user benefits. OBJECTIVE: The study aimed to present a systematic review of rates of adherence, dropout, and approaches to analyzing adherence to newly developed mobile and Web-based interventions for people with psychosis...
July 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28723697/the-history-and-future-of-ablative-neurosurgery-for-major-depressive-disorder
#15
Matthew Volpini, Peter Giacobbe, G Rees Cosgrove, Anthony Levitt, Andres M Lozano, Nir Lipsman
BACKGROUND: There is an urgent need to develop safe and effective treatments for patients with treatment-resistant depression (TRD). Several neurosurgical procedures have been developed to treat the dysfunctional brain circuits implicated in major depression. OBJECTIVES: This review describes the most common ablative procedures used to treat major depressive disorder: anterior cingulotomy, subcaudate tractotomy, limbic leucotomy, and anterior capsulotomy. The efficacy and safety of each are discussed and compared with other current and emerging modalities, including deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS)...
July 20, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28723515/understanding-mechanisms-of-resistance-in-metastatic-castration-resistant-prostate-cancer-the-role-of-the-androgen-receptor
#16
REVIEW
Derya Tilki, Edward M Schaeffer, Christopher P Evans
CONTEXT: After initiation of androgen deprivation therapy (ADT), most patients progress to castration-resistant prostate cancer (CRPC) within 2 or 3 yr. In the USA, approximately 67000 men are estimated to have metastatic CRPC. OBJECTIVE: To provide an overview of different mechanisms driving resistance to therapy in metastatic CRPC, with a focus on androgen receptor (AR)-dependent pathways. EVIDENCE ACQUISITION: A Medline search via PubMed was performed using the keywords metastatic castration resistant prostate cancer (mCRPC), castration-resistant, CRPC, prostate cancer, androgen resistance, hormone-refractory, hormone-independent, androgen receptor, and androgen receptor axis...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28713796/multimodal-imaging-in-focal-therapy-planning-and-assessment-in-primary-prostate-cancer
#17
Hossein Jadvar
PURPOSE: There is increasing interest in focal therapy (male lumpectomy) of localized low-intermediate risk prostate cancer. Focal therapy is typically associated with low morbidity and provides the possibility of retreatment. Imaging is pivotal in stratification of men with localized prostate cancer for active surveillance, focal therapy or radical intervention. This article provides a concise review of focal therapy and the evolving role of imaging in this clinical setting. METHODS: We performed a narrative and critical literature review by searching PubMed/Medline database from January 1997 to January 2017 for articles in the English language and the use of search keywords "focal therapy", "prostate cancer", and "imaging"...
June 2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28708011/effect-of-local-zoledronate-delivery-on-osseointegration-a-systematic-review-of-preclinical-studies
#18
Sergio Varela Kellesarian, Shatha Subhi ALHarthi, Munerah Saleh Binshabaib, Fawad Javed
PURPOSE: The aim of the present systematic review was to assess the effect of local zoledronate (ZOL) delivery (topical or as implant surface coatings) on osseointegration. MATERIALS AND METHODS: In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. To address the focused question, 'Does local zoledronate delivery enhance osseointegration?' indexed databases were searched without time or language restrictions up to and including April 2017 using various combination of the following keywords: 'zoledronate', 'bisphosphonates', 'osseointegration' and 'topical administration'...
July 14, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28707586/an-overview-of-new-possible-treatments-of-alzheimer-s-disease-based-on-natural-products-and-semi-synthetic-compounds
#19
Enrico Zanforlin, Giuseppe Zagotto, Giovanni Ribaud
BACKGROUND: Dementias and all related neurodegenerative diseases of the Central Nervous System (CNS) are a current issue arousing a great deal of interest in the international scientific community. This is due to the increasing number of patients suffering from these diseases. These pathologies represent a serious problem, not only concerning the quality of life of the patient, but in addition, the enormous economic efforts that society has to do for their treatment. There are currently a few strategies that are available in order to prevent the progression or to mitigate symptoms of the aforementioned diseases...
July 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28707192/-geriatrics-or-geriatricization-of-medicine-quo-vadis-geriatrics
#20
REVIEW
G F Kolb
This article examines the question whether and how geriatrics will change in the future and whether in view of the demographic changes the trend will go more in the direction of a further expansion of geriatrics or more towards a geriatricization of individual specialist medical fields. The different development of geriatrics in the individual Federal States can only be understood historically and is absolutely problematic against the background of the new hospital remuneration system. Geriatrics is a typical cross-sectional faculty and still has demarcation problems with other faculties but has also not yet clearly defined the core competence...
July 13, 2017: Zeitschrift Für Gerontologie und Geriatrie
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