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https://www.readbyqxmd.com/read/29167717/composition-and-physicochemical-properties-of-calcium-silicate-based-sealers-a-review-article
#1
REVIEW
Farnaz Jafari, Sanaz Jafari
Background: Recently a new generation of endodontic sealers has been developed based on calcium silicate as MTA Fillapex, Endoseal MTA, Total Fill BC Sealer, EndoSequence BC Sealer, iRoot SP, Endo CPM sealer, MTA-Angelus and ProRoot Endo Sealer. A review of literature was conducted to discuss the composition, physicochemical properties, and clinical perspectives of calcium silicate based sealers. Material and Methods: A literature search was conducted in PubMed and web of knowledge databases with appropriate MeSh terms and keywords...
October 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29163851/checkpoint-inhibitors-in-endometrial-cancer-preclinical-rationale-and-clinical-activity
#2
REVIEW
Gloria Mittica, Eleonora Ghisoni, Gaia Giannone, Massimo Aglietta, Sofia Genta, Giorgio Valabrega
Context: Treatment of advanced and recurrent endometrial cancer (EC) is still an unmet need for oncologists and gynecologic oncologists. The Cancer Genome Atlas Research Network (TCGA) recently provided a new genomic classification, dividing EC in four subgroups. Two types of EC, the polymerase epsilon (POLE)-ultra-mutated and the microsatellite instability-hyper-mutated (MSI-H), are characterized by a high mutation rate providing the rationale for a potential activity of checkpoint inhibitors...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29159874/meta-synthesis-on-migraine-management
#3
REVIEW
Mia T Minen, Lita Anglin, Alexandra Boubour, Allison Squires, Linda Herrmann
BACKGROUND: Migraine is one of the top 10 most disabling conditions among adults worldwide. Most migraine research is quantitative and indicates concerns about medication adherence, stigma, and more. Qualitative studies might reveal an improved understanding of migraine patients' perspectives regarding migraine treatment. OBJECTIVE: The aim of this study was to synthesize the qualitative research on migraine patients' perspectives regarding migraine treatment to (a) identify common patterns across various types of migraine treatment studies and (b) inform future research...
November 21, 2017: Headache
https://www.readbyqxmd.com/read/29145008/morphological-changes-in-erythrocytes-of-people-with-type-2-diabetes-mellitus-evaluated-with-atomic-force-microscopy-a-brief-review
#4
REVIEW
Alejandra Loyola-Leyva, Juan Pablo Loyola-Rodríguez, Marco Atzori, Francisco Javier González
Prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Cardiovascular diseases are one of the main causes of death among people with T2DM. Morphological changes in erythrocytes have been associated with higher risk of cardiovascular diseases. Atomic force microscopy (AFM) is a new technique that allows non-invasive imaging of cells and the evaluation of changes in mechanical properties. AIM: To evaluate by AFM the erythrocytes morphological changes of people with T2DM METHODS: Search was conducted from in PubMed, ScienceDirect, Scielo, and Lilacs...
November 10, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29141538/curcumin-a-natural-pan-hdac-inhibitor-in-cancer
#5
Sara Saffar Soflaei, Amir Abbas Momtazi, Muhammed Majeed, Giuseppe Derosa, Pamela Maffioli, Amirhossein Sahebkar
BACKGROUND: Histone deacetylases (HDACs) are a group of histone modification enzymes with pivotal role in disease pathogenesis especially in cancer development. Increased activity of certain types of HDACs and positive effects of HDAC inhibition has been shown in several types of cancers. Furthermore, few HDAC inhibitors have been approved by the FDA for cancer treatment, and this has generated interest in finding new HDAC inhibitors as potential anti-cancer agents. Curcumin, a natural polyphenol extracted from turmeric, is a safe and bioactive phytochemical with a wide range of molecular targets and pharmacological activities including promising anti-cancer properties...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29138195/current-status-of-postnatal-depression-smartphone-applications-available-on-application-stores-an-information-quality-analysis
#6
Melvyn Wb Zhang, Roger Cm Ho, Alvona Loh, Tracey Wing, Olivia Wynne, Sally Wai Chi Chan, Josip Car, Daniel Shuen Sheng Fung
OBJECTIVES: It is the aim of the current research to identify some common functionalities of postnatal application, and to determine the quality of the information content of postnatal depression application using validated scales that have been applied for applications in other specialties. SETTINGS AND PARTICIPANTS: To determine the information quality of the postnatal depression smartphone applications, the two most widely used smartphone application stores, namely Apple iTunes as well as Google Android Play store, were searched between 20May and 31 May...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29124449/the-evolution-of-public-health-ethics-frameworks-systematic-review-of-moral-values-and-norms-in-public-health-policy
#7
REVIEW
Mahmoud Abbasi, Reza Majdzadeh, Alireza Zali, Abbas Karimi, Forouzan Akrami
Given the evolution of the public health (PH) and the changes from the phenomenon of globalization, this area has encountered new ethical challenges. In order to find a coherent approach to address ethical issues in PH policy, this study aimed to identify the evolution of public health ethics (PHE) frameworks and the main moral values and norms in PH practice and policy. According to the research questions, a systematic search of the literature, in English, with no time limit was performed using the main keywords in databases Web of Science (ISI) and PubMed...
November 9, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29121905/the-trafficking-of-women-and-girls-in-taiwan-characteristics-of-victims-perpetrators-and-forms-of-exploitation
#8
Lanying Huang
BACKGROUND: Prior to the passing of 2009 Human Trafficking Prevention Act (HTPA), human trafficking was underestimated in Taiwan. In the past, domestic trafficking in women and girls often targeted vulnerable groups such as young girls from poor families or minority groups. Since the 1990s, an increasing flow of immigrant women, mainly from Vietnam and Indonesia and some from China, into Taiwan has created a new group of Human Trafficking victims. The current study intends to identify, describe, and categorize reported and prosecuted human trafficking cases involving women and girls according to the HTPA in Taiwan...
November 9, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29117198/mining-author-relationship-in-scholarly-networks-based-on-tripartite-citation-analysis
#9
Feifei Wang, Xiaohan Wang, Siluo Yang
Following scholars in Scientometrics as examples, we develop five author relationship networks, namely, co-authorship, author co-citation (AC), author bibliographic coupling (ABC), author direct citation (ADC), and author keyword coupling (AKC). The time frame of data sets is divided into two periods: before 2011 (i.e., T1) and after 2011 (i.e., T2). Through quadratic assignment procedure analysis, we found that some authors have ABC or AC relationships (i.e., potential communication relationship, PCR) but do not have actual collaborations or direct citations (i...
2017: PloS One
https://www.readbyqxmd.com/read/29117014/what-s-new-in-pediatric-upper-extremity-sports-injuries
#10
Jennifer J Beck, Connor G Richmond, Marc A Tompkins, Ann Heyer, Kevin G Shea, Aristides I Cruz
BACKGROUND: Sports injuries are common in pediatric and adolescent patients and the evaluation and treatment of these injuries continues to evolve. The purpose of this review is to provide a comprehensive appraisal of the most recent literature, highlighting updates on sports-related upper extremity injuries in pediatric patients. METHODS: An electronic search of the PubMed, EMBASE, and Google Scholar databases was performed for keywords related to pediatric overhead athletes, osteochondritis dissecans (OCD) of the capitellum, medial epicondyle fractures, shoulder instability, and clavicle fractures...
November 7, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29106619/npass-natural-product-activity-and-species-source-database-for-natural-product-research-discovery-and-tool-development
#11
Xian Zeng, Peng Zhang, Weidong He, Chu Qin, Shangying Chen, Lin Tao, Yali Wang, Ying Tan, Dan Gao, Bohua Wang, Zhe Chen, Weiping Chen, Yu Yang Jiang, Yu Zong Chen
There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines. In-silico methods have been employed for facilitating these studies. These studies and the optimization of in-silico algorithms for NP applications can be facilitated by the quantitative activity and species source data of the NPs. A number of databases collectively provide the structural and other information of ∼470 000 NPs, including qualitative activity information for many NPs, but only ∼4000 NPs are with the experimental activity values...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29103823/multiple-sclerosis-genetics-results-from-meta-analyses-of-candidate-gene-association-studies
#12
REVIEW
Kalthoum Tizaoui
As a complex disease, multiple sclerosis (MS) susceptibility implicates many genetic and environmental factors. Usually, individual genetic association studies have several limitations, and results are specific to the population of study. The Meta-analysis approach has been proposed to resolve these limitations and to increase the power of statistical analyses. In this review, we summarize results from meta-analyses of candidate genes of MS. Using the keywords: multiple sclerosis, genetic polymorphism and meta-analysis, we searched electronic databases (PubMed, Embase and Web of Sciences) for published meta-analyses until May 2017...
November 2, 2017: Cytokine
https://www.readbyqxmd.com/read/29102483/the-digital-environment-in-men-s-sexual-disorders-a-systematic-review
#13
E García-Cruz, J Romero-Otero, M Fode, A Alcaraz
CONTEXT: The revolution of digital technologies constitutes a new setting for the patient-physician relationship and provides patients with a scenario of privacy and universal access to a vast amount of information. However, there is little information on how digital resources are used and what their advantages and disadvantages are. OBJECTIVES: To explore the scope of the scientific research on the use of digital technology related to men's sexual disorders and to analyze the primary sources of digital information related to this field...
November 1, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29095836/mapping-longitudinal-scientific-progress-collaboration-and-impact-of-the-alzheimer-s-disease-neuroimaging-initiative
#14
Xiaohui Yao, Jingwen Yan, Michael Ginda, Katy Börner, Andrew J Saykin, Li Shen
BACKGROUND: Alzheimer's disease neuroimaging initiative (ADNI) is a landmark imaging and omics study in AD. ADNI research literature has increased substantially over the past decade, which poses challenges for effectively communicating information about the results and impact of ADNI-related studies. In this work, we employed advanced information visualization techniques to perform a comprehensive and systematic mapping of the ADNI scientific growth and impact over a period of 12 years...
2017: PloS One
https://www.readbyqxmd.com/read/29084046/using-clinical-notes-and-natural-language-processing-for-automated-hiv-risk-assessment
#15
Daniel J Feller, Jason Zucker, Michael T Yin, Peter Gordon, Noémie Elhadad
OBJECTIVE: Universal HIV screening programs are costly, labor-intensive, and often fail to identify high-risk individuals. Automated risk assessment methods that leverage longitudinal electronic health records (EHRs) could catalyze targeted screening programs. While social and behavioral determinants of health are typically captured in narrative documentation, previous analyses have considered only structured EHR fields. We examined whether natural language processing (NLP) would improve predictive models of HIV diagnosis...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29070077/linagliptin-versus-sitagliptin-in-patients-with-type-2-diabetes-mellitus-a-network-meta-analysis-of-randomized-clinical-trials
#16
REVIEW
Khosro Keshavarz, Farhad Lotfi, Ehsan Sanati, Mahmood Salesi, Amir Hashemi-Meshkini, Mojtaba Jafari, Mohammad M Mojahedian, Behzad Najafi, Shekoufeh Nikfar
BACKGROUND: Diabetes is one of the most common chronic and costly diseases worldwide and type 2 diabetes is the most common type which accounts for about 90% of cases with diabetes. New medication-therapy regimens such as those containing linagliptin alone or in combination with other medications (within the category of DDP-4 inhibitors) must be evaluated in terms of efficacy and compared with other currently used drugs and then enter the medication list of the country. Hence, this study aimed to compare the clinical efficacy of the two drugs, i...
October 25, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29061600/global-research-trends-in-spinal-ultrasound-a-systematic-bibliometric-analysis
#17
Xiao Zhai, Jin Cui, Jie Shao, Qijin Wang, Xiao Chen, Xianzhao Wei, Xiaoyi Zhou, Ziqiang Chen, Yushu Bai, Ming Li
BACKGROUND: In recent years, there has been increased interest in the use of ultrasound technology in the evaluation of spinal and paraspinal regions. OBJECTIVE: This study aimed to investigate trends in spinal ultrasound research from 1994 to 2015 and compare the contributions of such research from different countries and authors. STUDY DESIGN: Bibliometric analysis. SETTING: Publications related to spinal ultrasound from 1994 to 2015 were retrieved from the Web of Science database...
October 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29038665/c-reactive-protein-as-an-independent-cardiovascular-risk-predictor-in-hiv-patients-a-focused-review-of-published-studies
#18
REVIEW
Tarvinder S Gilotra, Stephen A Geraci
Patients infected with the human immunodeficiency virus (HIV+) are living longer and at heightened risk for developing cardiovascular events (CVEs). Commonly used prediction tools appear to misrepresent their CVE risk to varying degrees and in varying directions. Inclusion of markers of cellular infection, chronic immune activation and/or systemic inflammation into risk models might provide better predictive accuracy. Observational studies assessing the relationship of high-sensitivity C-reactive protein (hs-CRP) to CVE in HIV+ patients have reported inconsistent findings...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29034670/-community-based-research-in-therapeutic-patient-education-practices-and-contributions-a-literature-review
#19
Olivia Gross, Vincent de Andrade, Rémi Gagnayre
INTRODUCTION: Community-based research (CBR) in health involves both researchers and people concerned by the results of the research. It aims to empower populations, using their exposure to the phenomenon being studied as a starting point. The use of CBR in the field of therapeutic patient education (TPE) is of interest, as the two share such characteristics as the desire to foster self-reliance and participation and a culture of interdisciplinarity. AIM: To characterize CBR in the therapeutic patient education field...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29032071/comparing-intestinal-versus-diffuse-gastric-cancer-using-a-peff-oriented-proteomic-pipeline
#20
Helisa Helena Wippel, Marlon Dias Mariano Santos, Milan Avila Clasen, Louise Ulrich Kurt, Fabio Cesar Sousa Nogueira, Carlos Eduardo Carvalho, Thaís Messias McCormick, Guilherme Pinto Bravo Neto, Lysangela Ronalte Alves, Maria da Gloria da Costa Carvalho, Paulo Costa Carvalho, Juliana de Saldanha da Gama Fischer
Gastric cancer is the fifth most common malignant neoplasia and the third leading cause of cancer death worldwide. Mac-Cormick et al. recently showed the importance of considering the anatomical region of the tumor in proteomic gastric cancer studies; more differences were found between distinct anatomical regions than when comparing healthy versus diseased tissue. Thus, failing to consider the anatomical region could lead to differential proteins that are not disease specific. With this as motivation, we compared the proteomic profiles of intestinal and diffuse adenocarcinoma from the same anatomical region, the corpus...
October 11, 2017: Journal of Proteomics
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