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https://www.readbyqxmd.com/read/29773777/seeking-biomarkers-of-early-childhood-malnutrition-s-long-term-effects
#1
Pedro A Valdés-Sosa, Janina R Galler, Cyralene P Bryce, Arielle G Rabinowitz, María L Bringas-Vega, Nibaldo Hernández-Mesa, Alberto Taboada-Crispi
Protein-energy malnutrition affects one in nine people worldwide and is most prevalent among children aged less than five years in low-income countries. Early childhood malnutrition can have damaging neurodevelopmental effects, with significant increases in cognitive, neurological and mental health problems over the lifespan, outcomes which can also extend to the next generation. This article describes a research collaboration involving scientists from five centers in Barbados, China, Cuba and the USA. It builds on longer-term joint work between the Barbados Nutrition Study (which, over a 45-year span, has extensively documented nutritional, health, behavioral, social and economic outcomes of individuals who experienced protein-energy malnutrition in the first year of life and healthy controls from the same classrooms and neighborhoods) and the Cuban Neuroscience Center (which has developed low-cost brain imaging methods that can be readily used in low income settings to identify biomarkers for early detection and treatment of adverse consequences of childhood malnutrition)...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773775/case-study-in-international-cooperation-cuba-s-molecular-immunology-center-and-roswell-park-cancer-institute
#2
Rachel Evans, Mary Reid, Brahm Segal, Scott I Abrams, Kelvin Lee
In 1961, the USA severed diplomatic relations with Cuba, and in 1962 an embargo was imposed on trade and financial relations with that country. It was not until five decades later that the USA and Cuba would reestablish relations. This opened the way for the New York State Trade Mission to Cuba in April 2015, during which Cuba's Molecular Immunology Center and Buffalo, New York's Roswell Park Cancer Institute signed a formal agreement that would set in motion biotechnology research collaboration to address one of the most important causes of death in both countries...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773772/promoting-scientific-cooperation-in-times-of-diplomatic-challenges-sustained-partnership-between-the-cuban-academy-of-sciences-and-the-american-association-for-the-advancement-of-science
#3
Sergio Jorge-Pastrana, Marga Gual-Soler, Tom C Wang
Scientific research cooperation between Cuba and the USA has a long history that dates back to the 19th century. For the past 200 years, the two countries' relationship has been subject to complex economic, political and social forces. In the second half of the 20th century, the Cuban revolution and the subsequent escalation of the US government embargo impacted every aspect of Cuban life. While science was no exception, scientific interactions never ceased. Over the past decade, scientific cooperation-led and facilitated by scientific organizations such as the Cuban Academy of Sciences, the American Association for the Advancement of Science and others-has steadily increased to address ever more critical issues facing both countries...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29769777/alopecia-areata-review-of-epidemiology-clinical-features-pathogenesis-and-new-treatment-options
#4
REVIEW
Evan Darwin, Penelope A Hirt, Raymond Fertig, Brett Doliner, Gina Delcanto, Joaquin J Jimenez
Alopecia areata (AA) is a complex autoimmune condition that causes nonscarring hair loss. It typically presents with sharply demarcated round patches of hair loss and may present at any age. In this article, we review the epidemiology, clinical features, pathogenesis, and new treatment options of AA, with a focus on the immunologic mechanism underlying the treatment. While traditional treatment options such as corticosteroids are moderately effective, a better understanding of the disease pathogenesis may lead to the development of new treatments that are more directed and effective against AA...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29768934/a-safety-profile-of-medications-used-to-treat-waldenstr%C3%A3-m-s-macroglobulinemia
#5
Ramón García-Sanz, Cristina Jiménez, Verónica González de la Calle, María Eugenia Sarasquete
Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disease with serum IgM monoclonal component and bone marrow infiltration by lymphoplasmacytic lymphoma. Traditional therapy was based on that regimens used for closely related entities, such as chronic lymphocytic leukemia or multiple myeloma. This resulted in a lack of drugs specifically approved for WM, until the discovery of the BTK inhibitors. Areas covered. Two main therapeutic attitudes are possible: 1) conventional therapies based on combinations with alkylating agents or proteasome inhibitors with steroids and anti-CD20 monoclonal antibodies, or; 2) new approaches with BTK inhibitors, usually alone...
May 17, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29768544/response-to-different-benznidazole-doses-in-animal-models-of-chronic-phase-chagas-disease-a-critical-review
#6
Cauê Benito Scarim, Aline Rimoldi Ribeiro, João Aristeu da Rosa, Chung Man Chin
Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN)...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#7
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29765058/linguistic-measures-of-chemical-diversity-and-the-keywords-of-molecular-collections
#8
Michał Woźniak, Agnieszka Wołos, Urszula Modrzyk, Rafał L Górski, Jan Winkowski, Michał Bajczyk, Sara Szymkuć, Bartosz A Grzybowski, Maciej Eder
Computerized linguistic analyses have proven of immense value in comparing and searching through large text collections ("corpora"), including those deposited on the Internet - indeed, it would nowadays be hard to imagine browsing the Web without, for instance, search algorithms extracting most appropriate keywords from documents. This paper describes how such corpus-linguistic concepts can be extended to chemistry based on characteristic "chemical words" that span more than traditional functional groups and, instead, look at common structural fragments molecules share...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760723/applications-of-mesenchymal-stem-cells-in-sinus-lift-augmentation-as-a-dental-implant-technology
#9
REVIEW
Feridoun Parnia, Javad Yazdani, Solmaz Maleki Dizaj
The potential application of stem cell biology in human dentistry is a new and emerging field of research. The objective of the current review was to study the efficiency of mesenchymal stem cells (MSCs) in sinus lift augmentation (SLA). A literature review was performed in PubMed Central using MeSH keywords such as sinus lift, MSCs, dental implants, and augmentation. The searches involved full-text papers written in English, published in the past 10 years (2007-2017). The review included in vitro and in vivo studies on the use of MSCs in SLA...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29752613/immune-homeostasis-effects-of-chinese-herbal-formulae-and-herb-derived-compounds-on-allergic-asthma-in-different-experimental-models
#10
REVIEW
Lu Liu, Lin-Peng Wang, Shan He, Yan Ma
Allergic asthma is thought to arise from an imbalance of immune regulation, which is characterized by the production of large quantities of IgE antibodies by B cells and a decrease of the interferon-γ/interleukin-4 (Th1/Th2) ratio. Certain immunomodulatory components and Chinese herbal formulae have been used in traditional herbal medicine for thousands of years. However, there are few studies performing evidence-based Chinese medicine (CM) research on the mechanisms and effificacy of these drugs in allergic asthma...
May 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29751304/heavy-metal-loss-from-agricultural-watershed-to-aquatic-system-a-scientometrics-review
#11
REVIEW
Wei Ouyang, Yidi Wang, Chunye Lin, Mengchang He, Fanghua Hao, Hongbin Liu, Weihong Zhu
Heavy metal pollution in soil and aquatic environments has attracted widespread attention due to its persistence, accumulation in the food chain and negative effects on ecological and human health. However, analyses of the watershed-scale migration mechanisms of heavy metal loss from agricultural systems to aquatic systems have seldom been studied systematically. Therefore, this review summarizes the available data in the literature (2003-2017) using CiteSpace software to provide insights into the specific characteristics of heavy metal loss from agricultural watersheds to aquatic systems and consequently shows global development trends that scientists can use for establishing future research directions...
May 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29745321/selected-applications-for-current-polymers-in-prosthetic-dentistry-state-of-the-art
#12
Maciej Kawala, Joanna Smardz, Lukasz Adamczyk, Natalia Grychowska, Mieszko Wieckiewicz
BACKGROUND: Polymers are widely applied in medicine, including dentistry, i.e. in prosthodontics. AIM: The following paper is aimed at demonstrating the applications of selected modern polymers in prosthetic dentistry based on the reported literature. MATERIAL AND METHODS: The study was conducted using the PubMed, SCOPUS and CINAHL databases in relation to documents published during 1999-2017. The following keywords were used: polymers with: prosthetic dentistry, impression materials, denture base materials, bite registration materials, denture soft liners, occlusal splint materials and 3D printing...
May 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29739108/using-blood-and-plasma-micrornas-as-a-non-invasive-biomarker-in-patients-with-colorectal-cancer
#13
Horatiu Stefanescu, Delia Muntean, Ciprian Pilut, Mircea Diaconu, Roxana Popescu, Delia Hutanu, Marius Moise, Lighezan Diana, Razvan Nitu, Alina Popa Cherecheanu, Silvius Negoita, Ciprian V Iovan, Emil Ungureanu, Valentin Calu, Ioana Ciuca
BACKGROUND: A high percentage of oncological patients die yearly because of colorectal cancer (CRC). Worldwide, CRC represents the fourth leading cause of death among oncological patients. Numerous studies have been conducted in order to identify new biomarkers for the early diagnosis of patients with CRC. From this point of view, an ideal biomarker is represented by the expression of microRNAs. In this paper, we wish to summarize the expressions of microRNAs in CRC and to present the pathophysiological and genetic interactions that microRNAs have with protein systems in these patients...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736230/towards-optimal-platform-based-robot-design-for-ankle-rehabilitation-the-state-of-the-art-and-future-prospects
#14
REVIEW
Qing Miao, Mingming Zhang, Congzhe Wang, Hongsheng Li
This review aims to compare existing robot-assisted ankle rehabilitation techniques in terms of robot design. Included studies mainly consist of selected papers in two published reviews involving a variety of robot-assisted ankle rehabilitation techniques. A free search was also made in Google Scholar and Scopus by using keywords "ankle∗ ," and "robot∗ ," and ("rehabilitat∗ " or "treat∗ "). The search is limited to English-language articles published between January 1980 and September 2016...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29728555/prosthetic-rehabilitation-using-a-telescopic-crown-constructed-with-computer-assisted-design-and-computer-assisted-manufacturing-a-case-report-with-a-2-year-follow-up
#15
Nasser M Al Ahmari
Aim and background: This case report describes a 74-year-old female patient whose teeth were rehabilitated using telescopic crowns (TCs) on abutments and fixed dental prostheses (FDPs) in the maxillary arch with the aid of computer-assisted design and computer-assisted manufacturing (CAD/CAM) technology. The mandibular arch was restored using casted removable dental prostheses (RDPs) and surveyed crowns. Case report: The treatment sequences were followed as recommended in the dental literature. First, existing defective restorations were eliminated, caries was removed, and excellent mouth preparation was performed...
April 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29725783/stem-cell-therapy-for-osteonecrosis-of-the-femoral-head-current-trends-and-comprehensive-review
#16
REVIEW
Lei Zhao, Alan David Kaye, Aaron J Kaye, Alaa Abd-Elsayed
PURPOSE OF REVIEW: Osteonecrosis of the femoral head (ONFH) is a common and frequently occurring disease. It is caused by interruption of blood supply with different etiologies. ONFH leads to degeneration and necrosis of the subchondral bone of the femoral head and eventually collapse of the femoral head. ONFH has a high disability rate, seriously affecting the quality of living of patients, and often involves middle-aged and younger people. RECENT FINDINGS: In recent years, the technology and understanding of stem cells and regenerative medicine have been developing rapidly...
May 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29724217/tools-and-resources-for-neuroanatomy-education-a-systematic-review
#17
M Arantes, J Arantes, M A Ferreira
BACKGROUND: The aim of this review was to identify studies exploring neuroanatomy teaching tools and their impact in learning, as a basis towards the implementation of a neuroanatomy program in the context of a curricular reform in medical education. METHODS: Computer-assisted searches were conducted through March 2017 in the PubMed, Web of Science, Medline, Current Contents Connect, KCI and Scielo Citation Index databases. Four sets of keywords were used, combining "neuroanatomy" with "education", "teaching", "learning" and "student*"...
May 3, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29722342/gastric-cancer-screening-by-combined-determination-of-serum-helicobacter-pylori-antibody-and-pepsinogen-concentrations-abc-method-for-gastric-cancer-screening
#18
REVIEW
Xian-Zhe Chen, Cheng-Zhi Huang, Wei-Xian Hu, Ying Liu, Xue-Qing Yao
Objective: Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29720107/the-experience-of-women-with-an-eating-disorder-in-the-perinatal-period-a-meta-ethnographic-study
#19
Sarah Fogarty, Rakime Elmir, Phillipa Hay, Virginia Schmied
BACKGROUND: Pregnancy is a time of enormous body transformation. For those with an eating disorder during pregnancy this time of transformation can be distressing and damaging to both the mother and the child. In this meta-ethnographic study, we aimed to examine the experiences of women with an Eating Disorder in the perinatal period; that is during pregnancy and two years following birth. METHOD: A meta-ethnographic framework was used in this review. After a systematic online search of the literature using the keywords such as pregnancy, eating disorders, anorexia, bulimia, binge eating disorder, perinatal, postnatal and post-partum, 11 papers, involving 94 women, were included in the review...
May 2, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29719344/meta-analysis-of-the-efficacy-and-safety-of-repetitive-transcranial-magnetic-stimulation-rtms-in-the-treatment-of-depression
#20
REVIEW
Yanyan Wei, Junjuan Zhu, Shengke Pan, Hui Su, Hui Li, Jijun Wang
Background: Repetitive transcranial magnetic stimulation (rTMS) is a new type of physiotherapy technology that has been widely used in the research of depression. Although many clinical trials have found that compared to the placebo interventions, rTMS has a significant effect on the improvement of depressive symptoms, the outcomes remain inconsistent due to differences in rTMS treatment frequency, parameter settings, and site for stimulation. Aims: This study systematically evaluated the safety and efficacy of rTMS combined with antidepressants for the treatment of depression in Chinese and English randomized, double-blind and sham controlled trials and explored the possible related factors affecting the efficacy and safety...
December 25, 2017: Shanghai Archives of Psychiatry
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