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https://www.readbyqxmd.com/read/28214993/scaleus-semantic-web-services-integration-for-biomedical-applications
#1
Pedro Sernadela, Lorena González-Castro, José Luís Oliveira
In recent years, we have witnessed an explosion of biological data resulting largely from the demands of life science research. The vast majority of these data are freely available via diverse bioinformatics platforms, including relational databases and conventional keyword search applications. This type of approach has achieved great results in the last few years, but proved to be unfeasible when information needs to be combined or shared among different and scattered sources. During recent years, many of these data distribution challenges have been solved with the adoption of semantic web...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28212290/defining-clinical-response-criteria-and-early-response-criteria-for-precision-oncology-current-state-of-the-art-and-future-perspectives
#2
Vivek Subbiah, Hubert H Chuang, Dhiraj Gambhire, Kalevi Kairemo
In this era of precision oncology, there has been an exponential growth in the armamentarium of genomically targeted therapies and immunotherapies. Evaluating early responses to precision therapy is essential for "go" versus "no go" decisions for these molecularly targeted drugs and agents that arm the immune system. Many different response assessment criteria exist for use in solid tumors and lymphomas. We reviewed the literature using the Medline/PubMed database for keywords "response assessment" and various known response assessment criteria published up to 2016...
February 15, 2017: Diagnostics
https://www.readbyqxmd.com/read/28210454/managing-patients-taking-edoxaban-in-dentistry
#3
REVIEW
Adrian Curto, Daniel Curto, Jorge Sanchez
BACKGROUND: Anticoagulation therapy is used in several conditions to prevent or treat thromboembolism. A new group of oral anticoagulants with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. The Food and Drug Administration has approved edoxaban, dabigatran, rivaroxaban and apixaban. Their advantages include: predictable pharmacokinetics, drug interactions and limited food, rapid onset of action and short half-life...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210451/dental-management-of-patients-taking-novel-oral-anticoagulants-noas-dabigatran
#4
REVIEW
Adrian Curto, Alberto Albaladejo, Alfonso Alvarado
BACKGROUND: A new group of oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban) with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. Patients being treated with oral anticoagulants are at higher risk for bleeding when undergoing dental treatments. MATERIAL AND METHODS: A literature search was conducted through April 2016 for publications in the ISI Web of Knowledge, PubMed and Cochrane Library using the keywords "dabigatran", "rivaroxaban", "apixaban", "edoxaban", "new oral anticoagulants", "novel oral anticoagulants", "bleeding" and "dental treatment"...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28206730/sinus-presurgical-evaluation-a-literature-review-and-a-new-classification-proposal
#5
Lorenzo Tavelli, Andrea E Borgonovo, Dino Re, Carlo Maiorana
Presurgical evaluation with cone beam computed tomography (CBCT) or computed tomography (CT) has become an essential tool for diagnosis and surgical planning, including maxillary sinus floor elevation. Before performing a sinus lift, the clinician's attention should not be only directed to the patency of the ostium through CBCT or CT, because many anatomical features could influence the surgical approach of sinus floor elevation. The goal of this article was to facilitate the communication between clinicians regarding the type of maxillary sinus, encourage in-depth analysis prior to surgery and reduce the risk of complications due to possible underestimation of important parameters...
February 15, 2017: Minerva Stomatologica
https://www.readbyqxmd.com/read/28195271/recent-trends-in-surface-treatment-methods-for-bonding-composite-cement-to-zirconia-a-reveiw
#6
Aftab Ahmed Khan, Abdul Aziz A Al Kheraif, Syed Jamaluddin, Mohamad Elsharawy, Darshan Devang Divakar
PURPOSE: To evaluate the in vitro studies conducted in the last six years on new zirconia materials to discover and explore current trends in bonding composite cement to zirconia substrate. MATERIALS AND METHODS: An in-depth review of the in vitro studies performed between 2010 and 2016 was conducted, focusing on the current trends in surface conditioning methods for zirconia ceramic. PubMed was used for searching the literature. Resin composite bonding to zirconia, zirconia surface coating, and zirconia surface treatment method were the keywords used...
February 10, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28190380/passive-prosthetic-hands-and-tools-a-literature-review
#7
Bartjan Maat, Gerwin Smit, Dick Plettenburg, Paul Breedveld
BACKGROUND: The group of passive prostheses consists of prosthetic hands and prosthetic tools. These can either be static or adjustable. Limited research and development on passive prostheses has been performed although many people use these prosthesis types. Although some publications describe passive prostheses, no recent review of the peer-reviewed literature on passive prostheses is available. OBJECTIVE: Review the peer-reviewed literature on passive prostheses for replacement of the hand...
February 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28185576/var2go-a-web-based-tool-for-gene-variants-selection
#8
Ilaria Granata, Mara Sangiovanni, Francesco Maiorano, Marco Miele, Mario Rosario Guarracino
BACKGROUND: One of the most challenging issue in the variant calling process is handling the resulting data, and filtering the genes retaining only the ones strictly related to the topic of interest. Several tools permit to gather annotations at different levels of complexity for the detected genes and to group them according to the pathways and/or processes they belong to. However, it might be a time consuming and frustrating task. This is partly due to the size of the file, that might contain many thousands of genes, and to the search of associated variants that requires a gene-by-gene investigation and annotation approach...
November 8, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28183295/meta-analysis-of-gene-expression-in-relapsed-childhood-b-acute-lymphoblastic-leukemia
#9
Yock-Ping Chow, Hamidah Alias, Rahman Jamal
BACKGROUND: Relapsed pediatric B-acute lymphoblastic leukemia (B-ALL) remains as the leading cause of cancer death among children. Other than stem cell transplantation and intensified chemotherapy, no other improved treatment strategies have been approved clinically. Gene expression profiling represents a powerful approach to identify potential biomarkers and new therapeutic targets for various diseases including leukemias. However, inadequate sample size in many individual experiments has failed to provide adequate study power to yield translatable findings...
February 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28174067/health-literacy-in-the-ehealth-era-a-systematic-review-of-the-literature
#10
REVIEW
Henna Kim, Bo Xie
OBJECTIVES: This study aimed to identify studies on online health service use by people with limited health literacy, as the findings could provide insights into how health literacy has been, and should be, addressed in the eHealth era. METHODS: To identify the relevant literature published since 2010, we performed four rounds of selection-database selection, keyword search, screening of the titles and abstracts, and screening of full texts. This process produced a final of 74 publications...
January 28, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28163978/gmove-group-level-mobility-modeling-using-geo-tagged-social-media
#11
Chao Zhang, Keyang Zhang, Quan Yuan, Luming Zhang, Tim Hanratty, Jiawei Han
Understanding human mobility is of great importance to various applications, such as urban planning, traffic scheduling, and location prediction. While there has been fruitful research on modeling human mobility using tracking data (e.g., GPS traces), the recent growth of geo-tagged social media (GeoSM) brings new opportunities to this task because of its sheer size and multi-dimensional nature. Nevertheless, how to obtain quality mobility models from the highly sparse and complex GeoSM data remains a challenge that cannot be readily addressed by existing techniques...
August 2016: KDD: Proceedings
https://www.readbyqxmd.com/read/28158165/ketamine-an-update-on-cellular-and-subcellular-mechanisms-with-implications-for-clinical-practice
#12
Gary J Iacobucci, Ognjen Visnjevac, Leili Pourafkari, Nader Djalal Nader
BACKGROUND: Ketamine is one of the oldest hypnotic agents used to provide an anesthetic agent with analgesic properties and minimal suppressive effects on respiration. The ability of ketamine in modulating glutamatergic (N-methyl D-aspartate) pain receptors has made this anesthetic drug a new option for the management of patients with chronic pain syndromes. Further preclinical and clinical findings suggest ketamine may have wide ranging effects on both cognition and development. Recent advances have revealed an unprecedented role for ketamine in the acute management of depression...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28152846/cancer-communication-in-the-social-media-age-could-twitter-help-clinical-trial-accrual
#13
Roger B Cohen, Raina M Merchant, Marilyn M Schapira
: 194 Background: Twitter, a social networking site, is transforming communication. Effective use of Twitter might be one way to communicate with the public about cancer clinical trials and increase awareness and perhaps enrollment. We conducted a content analysis of tweets about lung cancer, describing dialogues specific to lung cancer clinical trials and seeing where embedded-links in tweets about therapeutic trials are leading the public. METHODS: We used the Twitter search engine to identify a cohort of 26,059 tweets with the keyword "lung cancer" from January 5 - 21, 2015...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28135103/ultrafast-molecular-stitching-of-graphene-films-at-the-ethanol-water-interface-for-high-volumetric-capacitance
#14
Gang Lian, Chia-Chi Tuan, Liyi Li, Shilong Jiao, Kyoung-Sik Moon, Qilong Wang, Deliang Cui, Ching-Ping Wong
Compact graphene film electrodes with high ion-accessible surface area have the promising potential to realize high-density electrochemical energy storage (or high volumetric capacitance), which is vital for the development of flexible, portable and wearable energy storage devices. Here, a novel, ultrafast strategy for stitching graphene sheets into films, in which p-phenylenediamine (PPD) molecules are uniformly intercalated between the graphene sheets, is simply constructed at the ethanol/water interface...
January 30, 2017: Nano Letters
https://www.readbyqxmd.com/read/28128466/accounts-of-bullying-on-twitter-in-relation-to-dentofacial-features-and-orthodontic-treatment
#15
C Austin, J S Antoun, K C Morgaine, M Farella
BACKGROUND: Social media offers an accessible resource for gaining unrestricted insights into the social culture of bullying. OBJECTIVE: To qualitatively analyze Twitter posts for common themes relating to dentofacial features, braces, and bullying. METHODS: Twitter's database was searched from 2010 to 2014 using keywords relevant to bullying, teeth and orthodontics. Two investigators assessed the Twitter posts, and selected those that conveyed the experiences or opinions of bullying victims...
January 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28108483/measuring-hip-muscle-strength-in-patients-with-femoroacetabular-impingement-and-other-hip-pathologies-a-systematic-review
#16
E Mayne, A Memarzadeh, P Raut, A Arora, V Khanduja
OBJECTIVES: The aim of this study was to systematically review the literature on measurement of muscle strength in patients with femoroacetabular impingement (FAI) and other pathologies and to suggest guidelines to standardise protocols for future research in the field. METHODS: The Cochrane and PubMed libraries were searched for any publications using the terms 'hip', 'muscle', 'strength', and 'measurement' in the 'Title, Abstract, Keywords' field. A further search was performed using the terms 'femoroacetabular' or 'impingement'...
January 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28100439/considerations-for-an-access-centered-design-of-the-fever-thermometer-in-low-resource-settings-a-literature-review
#17
REVIEW
Rikako Iwamoto, Ana Laura Rodrigues Santos, Niels Chavannes, Ria Reis, Jan Carel Diehl
BACKGROUND: The lack of adequate information about fever in low-resource settings, its unreliable self-assessment, and poor diagnostic practices may result in delayed care and under-or-overdiagnosis of diseases such as malaria. The mismatches of existing fever thermometers in the context of use imply that the diagnostic tools and connected services need to be studied further to address the challenges of fever-related illnesses and their diagnostics. OBJECTIVE: This study aims to inform a product-service system approach to design a reliable and accessible fever thermometer and connected services, as well as contribute to the identification of innovative opportunities to improve health care in low-resource settings...
January 18, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28099838/osteoarthritis-year-in-review-2016-biomarkers-biochemical-markers
#18
REVIEW
A Mobasheri, A-C Bay-Jensen, W E van Spil, J Larkin, M C Levesque
PURPOSE: The aim of this "Year in Review" article is to summarize and discuss the implications of biochemical marker related articles published between the Osteoarthritis Research Society International (OARSI) 2015 Congress in Seattle and the OARSI 2016 Congress in Amsterdam. METHODS: The PubMed/MEDLINE bibliographic database was searched using the combined keywords: 'biomarker' and 'osteoarthritis'. The PubMed/MEDLINE literature search was conducted using the Advanced Search Builder function (http://www...
February 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28095262/biosimilars-in-inflammatory-bowel-disease-accumulating-clinical-evidence
#19
Sean McConachie, Sheila M Wilhelm, Pramodini B Kale-Pradhan
Biologic antagonists to tumor necrosis factor alpha (TNF- α) are effective medications and have become well established in the treatment of both Crohn's disease and ulcerative colitis. Biosimilar medications, which are medications deemed to be equivalent to reference biologic products in terms of clinical effectiveness, safety, pharmacokinetic analysis, and immunogenicity, have now been approved in inflammatory bowel diseases (IBD) based on indication exploration from clinical data in alternate disease states...
January 29, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28092758/between-a-rock-and-a-hard-place-economic-expansion-and-social-responsibility-in-uk-media-discourses-on-the-global-alcohol-industry
#20
Mary Thornton, Benjamin Hawkins
CONTEXT: Transnational alcohol corporations (TACs) employ a range of strategies to achieve their business objectives, including attempts to frame perceptions of their activities in media debates. TACs aim to achieve a favourable regulatory environment by presenting themselves as socially responsible actors. However, the need to secure financial investment means they must also emphasise their potential for growth. This article investigates tensions between these objectives in coverage of the global alcohol industry in the UK print media...
February 2017: Social Science & Medicine
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