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Pre-conditioning

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https://www.readbyqxmd.com/read/29236177/effect-of-er-yag-laser-enamel-conditioning-and-moisture-on-the-microleakage-of-a-hydrophilic-sealant
#1
Zeynep Aslı Güçlü, Andrew Paul Hurt, Nazmiye Dönmez, Nichola Jayne Coleman
For a given sealant, successful pit and fissure sealing is principally governed by the enamel conditioning technique and the presence of moisture contamination. A new generation of hydrophilic resin sealants is reported to tolerate moisture. This study investigates the impact of Er:YAG laser pre-conditioning and moisture contamination on the microleakage of a recent hydrophilic sealant. Occlusal surfaces of extracted human molars were either acid etched (n = 30), or successively lased and acid etched (n = 30)...
December 13, 2017: Odontology
https://www.readbyqxmd.com/read/29220400/social-structure-opportunistic-punishment-and-the-evolution-of-honest-signaling
#2
Robin Clark, Steven O Kimbrough
Honest signaling is generally taken to be a necessary pre-condition for a stable signaling system, because deceptive signaling at a high enough rate should cause receivers to ignore the signal, which in turn undermines the utility of sending signals. Deception is normally thought to occur because of benefits it has to the deceiver. This raises the question of why signaling systems should exist and persist over time, especially in cases in which the interests of the senders and receivers are not well aligned...
2017: PloS One
https://www.readbyqxmd.com/read/29208472/role-of-transglutaminase-2-in-a1-adenosine-receptor-and-%C3%AE-2-adrenoceptor-mediated-pharmacological-pre-and-post-conditioning-against-hypoxia-reoxygenation-induced-cell-death-in-h9c2-cells
#3
Falguni S Vyas, Carl P Nelson, John M Dickenson
Pharmacologically-induced pre- and post-conditioning represent attractive therapeutic strategies to reduce ischaemia/reperfusion injury during cardiac surgery and following myocardial infarction. We have previously reported that transglutaminase 2 (TG2) activity is modulated by the A1 adenosine receptor and β2-adrenoceptor in H9c2 cardiomyoblasts. The primary aim of this study was to determine the role of TG2 in A1 adenosine receptor and β2-adrenoceptor-induced pharmacological pre- and post-conditioning in the H9c2 cells...
December 2, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29205959/maintenance-and-assessment-of-cell-viability-in-formulation-of-non-sporulating-bacterial-inoculants
#4
REVIEW
Teresa Berninger, Óscar González López, Ana Bejarano, Claudia Preininger, Angela Sessitsch
The application of beneficial, plant-associated microorganisms is a sustainable approach to improving crop performance in agriculture. However, microbial inoculants are often susceptible to prolonged periods of storage and deleterious environmental factors, which negatively impact their viability and ultimately limit efficacy in the field. This particularly concerns non-sporulating bacteria. To overcome this challenge, the availability of protective formulations is crucial. Numerous parameters influence the viability of microbial cells, with drying procedures generally being among the most critical ones...
December 4, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29203900/intracellular-immunization-against-hiv-infection-with-an-intracellular-antibody-that-mimics-hiv-integrase-binding-to-the-cellular-ledgf-protein
#5
Leyuan Bao, Clare Hannon, Abimael Cruz-Mignoni, Denis Ptchelkine, Mei-Yi Sun, Ami Miller, Wilawan Bunjobpol, Camilo E Quevedo, Mariliza Derveni, Jennifer Chambers, Alison Simmons, Simon E V Phillips, Terence H Rabbitts
Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technology to isolate a single VH antibody domain that binds to LEDGF. The crystal structure of the LEDGF-VH complex reveals that the single domain antibody mimics the effect of binding of HIV integrase to LEDGF which is crucial for HIV propagation...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29198726/neopterin-preconditioning-prevents-inflammasome-activation-in-mammalian-astrocytes
#6
Roberta de Paula Martins, Karina Ghisoni, Chai K Lim, Aderbal Silva Aguiar, Gilles J Guillemin, Alexandra Latini
Neopterin, a well-established biomarker for immune system activation, is found at increased levels in the cerebrospinal fluid of individuals affected by neurological/neurodegenerative diseases. Here, neopterin synthesis was investigated in different nerve cells (rodent and human) and in the mouse hippocampus under inflammatory stimuli. We also aimed to investigate whether neopterin preconditioning could modulate the inflammasome activation, a component of the innate immune system. Increased neopterin was detected in human nerve cells supernatants (highest secretion in astrocytes) exposed to lipopolysaccharide (LPS) and interferon-gamma (INF-γ) and in the hippocampus of mice receiving LPS (0...
November 30, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29187153/similar-but-different-structurally-related-azelaic-acid-and-hexanoic-acid-trigger-differential-metabolomic-and-transcriptomic-responses-in-tobacco-cells
#7
Arnaud T Djami-Tchatchou, Efficient N Ncube, Paul A Steenkamp, Ian A Dubery
BACKGROUND: Plants respond to various stress stimuli by activating an enhanced broad-spectrum defensive ability. The development of novel resistance inducers represents an attractive, alternative crop protection strategy. In this regard, hexanoic acid (Hxa, a chemical elicitor) and azelaic acid (Aza, a natural signaling compound) have been proposed as inducers of plant defense, by means of a priming mechanism. Here, we investigated both the mode of action and the complementarity of Aza and Hxa as priming agents in Nicotiana tabacum cells in support of enhanced defense...
November 29, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29180107/limited-transfer-of-visual-skill-to-locations-treated-by-pre-testing-and-subliminal-exposure
#8
Gesa Lange, Peter De Weerd
Substantial transfer of perceptual skill learning can be achieved across large distances in the visual field by a brief pre-test, training-plus-exposure, or a double-training paradigm (Current Biology 18 (2008) 1922-1926; Vision Research 50 (2010) 368-374; The Journal of Neuroscience 30 (2010) 12323-12328). Additionally, subliminal exposure has been shown to be beneficial for subsequent perceptual learning. Here, we tested the generalization of orientation discrimination learning from a fully trained location towards four other test locations, either in the same or opposite hemifield as the training location, which each were subjected to a different type of pre-conditioning...
November 24, 2017: Vision Research
https://www.readbyqxmd.com/read/29179571/the-role-of-basal-cells-in-producing-persistent-lentivirus-mediated-airway-gene-expression
#9
Nigel R Farrow, Martin Donnelley, Patricia Cmielewski, Eugene Roscioli, Nathan Rout-Pitt, Chantelle McIntyre, Ivan Bertoncello, David Parsons
RATIONALE: Cystic Fibrosis (CF) lung disease is an ideal candidate for a genetic therapy. We have previously shown that pre-conditioning with lysophosphatidylcholine (LPC) prior to lentiviral (LV) vector delivery results in long-term in vivo gene expression in the airway epithelium of CF mice. We hypothesise that this outcome is largely due to transduction of airway basal cells that in turn pass the transgene onto their progeny. OBJECTIVES: The aim of these studies was to confirm if the in vivo delivery of a HIV-1 VSV-G pseudotyped LV vector following LPC airway conditioning results in transduction of mouse airway basal cells in situ and if the transgene is passed onto their progeny...
November 27, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29177607/building-healthy-start-grantees-capacity-to-achieve-collective-impact-lessons-from-the-field
#10
Kimberly Bradley, Karuna S Chibber, Naima Cozier, Peggy Vander Meulen, Colleen Ayres-Griffin
Purpose While Healthy Start has emphasized the need for multi-sectorial community engagement and collaboration since its inception, in 2014 Healthy Start adopted Collective Impact (CI) as a framework for reducing infant mortality. This paper describes the development of a peer-focused capacity-building strategy that introduced key elements of CI and preliminary findings of Healthy Start grantees' progress with using CI as an approach to collaboration. Description The Collective Impact Peer Learning Networks (CI-PLNs) consisted of eight 90-min virtual monthly meetings and one face-to-face session that reviewed CI pre-conditions and conditions...
November 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29164625/mechanisms-and-mitochondrial-redox-signaling-in-photobiomodulation
#11
Michael R Hamblin
Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29155609/using-neural-networks-to-predict-hfacs-unsafe-acts-from-the-pre-conditions-of-unsafe-acts
#12
Don Harris, Wen-Chin Li
HFACS (Human Factors Analysis and Classification System) is based upon Reason's (1990; 1997) organizational model of human error which suggests that there is a 'one to many' mapping of condition tokens (HFACS level 2 psychological precursors) to unsafe act tokens (HFACS level 1 error and violations). Using accident data derived from 523 military aircraft accidents, the relationship between HFACS level 2 pre-conditions and level 1 unsafe acts was modelled using an artificial Neural Network (NN). This allowed an empirical model to be developed congruent with the underlying theory of HFACS...
November 18, 2017: Ergonomics
https://www.readbyqxmd.com/read/29149820/mechanisms-of-cardioprotection-of-halogenated-agents-during-extracorporeal-circulation-in-cardiac-surgery
#13
M Ramirez Aliaga, J J Escalona Belmonte, Alicia Ramirez-Fernandez, M Rubio Navarro, J Cruz Manas
The implementation of cardioprotective strategies involving pre-, intra-, and postoperative interventions is key during cardiac surgery requiring extracorporeal circulation (ECC). The primary goal of this study was to review the physiopathology of and protection strategies against myocardial damage secondary to ECC during cardiac surgery. The administration of halogenated anesthetics for cardiac anesthesia is commonplace due to their well-known cardioprotective effects and their capacity to ensure hypnosis...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29146411/metabolic-adaptation-to-intermittent-fasting-is-independent-of-peroxisome-proliferator-activated-receptor-alpha
#14
Guolin Li, Chad N Brocker, Tingting Yan, Cen Xie, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez
BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARA) is a major regulator of fatty acid oxidation and severe hepatic steatosis occurs during acute fasting in Ppara-null mice. Thus, PPARA is considered an important mediator of the fasting response; however, its role in other fasting regiments such as every-other-day fasting (EODF) has not been investigated. METHODS: Mice were pre-conditioned using either a diet containing the potent PPARA agonist Wy-14643 or an EODF regimen prior to acute fasting...
November 6, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29121035/ischemic-conditioning-of-human-heart-muscle-depends-on-opioid-receptor-system
#15
Marcin Kunecki, Tomasz Oleksy, Jolanta Biernat, Paweł Kukla, Katarzyna Szwajkos, Piotr Podolec, Marek Deja, Krzysztof Gołba, Wojciech Płazak
BACKGROUND: Despite progress in the invasive treatment of ischemic heart disease, the ability to limit ischemia-reperfusion (I/R) injury remains largely unrealized. Ischemic pre-conditioning (IPC) and post-conditioning (POC) induce the protective mechanisms of resistance against I/R injury. Stimulation of opioid receptors mimic the protective effect of IPC or POC in an animal models. We tested the hypothesis, that IPC and POC provide cardioprotection in opioid-dependent mechanism in human myocardium...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29120984/effects-of-different-resistance-training-systems-on-muscular-strength-and-hypertrophy-in-resistance-trained-older-women
#16
Alex S Ribeiro, Andreo F Aguiar, Brad J Schoenfeld, João Pedro Nunes, Edilaine F Cavalcanti, Eduardo L Cadore, Edilson S Cyrino
The purpose of this study was to investigate the effect of resistance training (RT) performed in a pyramid (PR) versus constant (CT) load system on muscular strength and hypertrophy in resistance-trained older women. Thirty-three older women (69.7±5.9 years, 69.1±15.0 kg, 156.6±6.2 cm, and 28.1±5.4 kg.m) were randomized into 2 groups: one that performed RT with a CT load (n = 16) and another group that performed RT in an ascending PR fashion (n = 17). Outcomes included 1 repetition maximum (RM) tests and assessment of skeletal muscle mass estimated by dual energy X-ray absorptiometry...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29098143/architecture-and-prototypical-implementation-of-a-semantic-querying-system-for-big-earth-observation-image-bases
#17
Dirk Tiede, Andrea Baraldi, Martin Sudmanns, Mariana Belgiu, Stefan Lang
Spatiotemporal analytics of multi-source Earth observation (EO) big data is a pre-condition for semantic content-based image retrieval (SCBIR). As a proof of concept, an innovative EO semantic querying (EO-SQ) subsystem was designed and prototypically implemented in series with an EO image understanding (EO-IU) subsystem. The EO-IU subsystem is automatically generating ESA Level 2 products (scene classification map, up to basic land cover units) from optical satellite data. The EO-SQ subsystem comprises a graphical user interface (GUI) and an array database embedded in a client server model...
2017: European Journal of Remote Sensing
https://www.readbyqxmd.com/read/29095944/mif-inhibition-interferes-with-the-inflammatory-and-t-cell-stimulatory-capacity-of-nod-macrophages-and-delays-autoimmune-diabetes-onset
#18
Hannelie Korf, Laura Breser, Jelter Van Hoeck, Janet Godoy, Dana P Cook, Benoit Stijlemans, Elien De Smidt, Carolien Moyson, João Paulo Monteiro Carvalho Mori Cunha, Virginia Rivero, Conny Gysemans, Chantal Mathieu
Macrophages contribute in the initiation and progression of insulitis during type 1 diabetes (T1D). However, the mechanisms governing their recruitment into the islets as well as the manner of retention and activation are incompletely understood. Here, we investigated a role for macrophage migration inhibitory factor (MIF) and its transmembrane receptor, CD74, in the progression of T1D. Our data indicated elevated MIF concentrations especially in long-standing T1D patients and mice. Additionally, NOD mice featured increased MIF gene expression and CD74+ leukocyte frequencies in the pancreas...
2017: PloS One
https://www.readbyqxmd.com/read/29081955/design-of-an-enantioselective-artificial-metallo-hydratase-enzyme-containing-an-unnatural-metal-binding-amino-acid
#19
Ivana Drienovská, Lur Alonso-Cotchico, Pietro Vidossich, Agustí Lledós, Jean-Didier Maréchal, Gerard Roelfes
The design of artificial metalloenzymes is a challenging, yet ultimately highly rewarding objective because of the potential for accessing new-to-nature reactions. One of the main challenges is identifying catalytically active substrate-metal cofactor-host geometries. The advent of expanded genetic code methods for the in vivo incorporation of non-canonical metal-binding amino acids into proteins allow to address an important aspect of this challenge: the creation of a stable, well-defined metal-binding site...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29079818/mmp-proteolytic-activity-regulates-cancer-invasiveness-by-modulating-integrins
#20
Alakesh Das, Melissa Monteiro, Amlan Barai, Sandeep Kumar, Shamik Sen
Cancer invasion through dense extracellular matrices (ECMs) is mediated by matrix metalloproteinases (MMPs) which degrade the ECM thereby creating paths for migration. However, how this degradation influences the phenotype of cancer cells is not fully clear. Here we address this question by probing the function of MMPs in regulating biophysical properties of cancer cells relevant to invasion. We show that MMP catalytic activity regulates cell spreading, motility, contractility and cortical stiffness by stabilizing integrins at the membrane and activating focal adhesion kinase...
October 27, 2017: Scientific Reports
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