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https://www.readbyqxmd.com/read/28820983/a-sensitive-method-for-the-separation-and-quantification-of-low-level-adenine-nucleotides-using-porous-graphitic-carbon-based-liquid-chromatography-and-tandem-mass-spectrometry
#1
Sonia Bustamante, Robert B Gilchrist, Dulama Richani
A liquid chromatography coupled to heated electrospray ionization/tandem mass spectrometry (LC-HESI-MS/MS) method was developed for the simultaneous quantitative analysis of low nanomolar level adenine nucleotides AMP, ADP, ATP, cyclic AMP (cAMP), and the nucleoside adenosine. For analyte retention and separation, reverse phase chromatography using porous graphitic carbon (PGC) was employed as it provided full resolution. The erratic chromatographic behaviour characteristic of PGC, including deterioration of analyte resolution and increased peak tailing (leading to decreased sensitivity), was mitigated by incorporating acidic equilibration within runs using a quaternary gradient...
July 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28817483/time-course-study-on-left-ventricular-function-in-a-rabbit-model-of-ischemia-reperfusion-injury-with-morphine-preconditioning
#2
Baihua Zhao, Chengxiao Liu, Darong Pu, Shi Zeng, Xi Dai, Minghui Liu
AIMS: The study aimed to analyze the left ventricular longitudinal function in a rabbit model of myocardial ischemia-reperfusion with morphine preconditioning through strain rate imaging and evaluate the effect of morphine preconditioning. METHODS: A myocardial ischemia-reperfusion model was induced by occlusion and recanalization of the coronary artery in forty male New Zealand white rabbits, which were divided into a sham group, morphine group, and vehicle control group...
August 15, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28816238/acute-myeloid-leukemia-transforms-the-bone-marrow-niche-into-a-leukemia-permissive-microenvironment-through-exosome-secretion
#3
B Kumar, M Garcia, L Weng, X Jung, J L Murakami, X Hu, T McDonald, A Lin, A R Kumar, D L DiGiusto, A S Stein, V A Pullarkat, S K Hui, N Carlesso, Y-H Kuo, R Bhatia, G Marcucci, C-C Chen
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia-growth-permissive and normal-hematopoiesis-suppressive microenvironment through exosome secretion. Either engrafted AML cells or AML-derived exosomes increased mesenchymal stromal progenitors and blocked osteolineage development and bone formation in vivo. Pre-conditioning with AML-derived exosomes 'primed' the animals for accelerated AML growth...
August 17, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28813422/perceived-public-transport-infrastructure-modifies-the-association-between-public-transport-use-and-mental-health-multilevel-analyses-from-the-united-kingdom
#4
Xiaoqi Feng, Zhiqiang Feng, Thomas Astell-Burt
AIMS: Investments to promote public transport utilisation are being championed to achieve sustainable development, but the potential co-benefits for mental health are comparatively under-researched. We hypothesised that frequent users of public transport would be more likely to have better mental health (possibly due to increased levels of physical activity), but among the more frequent users, less favourable perceptions of public transport infrastructure (PPTI) could have a negative influence on mental health...
2017: PloS One
https://www.readbyqxmd.com/read/28808637/effects-of-air-abrasion-pressure-on-the-resin-bond-strength-to-zirconia-a-combined-cyclic-loading-and-thermocycling-aging-study
#5
Eman Z Al-Shehri, Afnan O Al-Zain, Alaa H Sabrah, Sarah S Al-Angari, Laila Al Dehailan, George J Eckert, Mutlu Özcan, Jeffrey A Platt, Marco C Bottino
OBJECTIVES: To determine the combined effect of fatigue cyclic loading and thermocycling (CLTC) on the shear bond strength (SBS) of a resin cement to zirconia surfaces that were previously air-abraded with aluminum oxide (Al2O3) particles at different pressures. MATERIALS AND METHODS: Seventy-two cuboid zirconia specimens were prepared and randomly assigned to 3 groups according to the air-abrasion pressures (1, 2, and 2.8 bar), and each group was further divided into 2 groups depending on aging parameters (n = 12)...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28777945/long-term-engraftment-of-primary-bone-marrow-stromal-cells-repairs-niche-damage-and-improves-hematopoietic-stem-cell-transplantation
#6
Jean-Paul Abbuehl, Zuzana Tatarova, Werner Held, Joerg Huelsken
Hematopoietic stem cell (HSC) transplantation represents a curative treatment for various hematological disorders. However, delayed reconstitution of innate and adaptive immunity often causes fatal complications. HSC maintenance and lineage differentiation are supported by stromal niches, and we now find that bone marrow stroma cells (BMSCs) are severely and permanently damaged by the pre-conditioning irradiation required for efficient HSC transplantation. Using mouse models, we show that stromal insufficiency limits the number of donor-derived HSCs and B lymphopoiesis...
August 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28769855/ratings-of-perceived-exertion-and-self-reported-mood-state-in-response-to-high-intensity-interval-training-a-crossover-study-on-the-effect-of-chronotype
#7
Jacopo A Vitale, Antonio La Torre, Roberto Baldassarre, Maria F Piacentini, Matteo Bonato
The aim of this study was to investigate the influence of chronotype on mood state and ratings of perceived exertion (RPE) before and in response to acute high intensity interval exercise (HIIE) performed at different times of the day. Based on the morningness-eveningness questionnaire, 12 morning-types (M-types; N = 12; age 21 ± 2 years; height 179 ± 5 cm; body mass 74 ± 12 kg) and 11 evening-types (E-types; N = 11; age 21 ± 2 years; height 181 ± 11 cm; body mass 76 ± 11 kg) were enrolled in a randomized crossover study...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28769546/the-development-of-the-mind-a-three-month-old-infant
#8
Simone Setterberg
Infant mental development occurs in interplay with a caregiver. The infant establishes an inner world, a psyche, by using his or her caregiver as transitional mental space for the development of a sense of self. This mental progress occurs simultaneously with motor elaboration, pre-conditioned by neurophysiological maturation. The bodily holding function of the caregiver, through initial skin-to-skin contact, enables the infant to develop a sense of bodily self. The pivotal role of the body as a first place of ego development is illustrated by the vignette of Nino, a 3-month-old infant whose caregiver is unable to provide the necessary physical contact, and therefore insufficiently containing the young infant...
February 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28760703/berberine-induced-cardioprotection-and-sirt3-modulation-in-doxorubicin-treated-h9c2-cardiomyoblasts
#9
Ana R Coelho, Tatiana R Martins, Renata Couto, Cláudia Deus, Cláudia V Pereira, Rui F Simões, Albert A Rizvanov, Filomena Silva, Teresa Cunha-Oliveira, Paulo J Oliveira, Teresa L Serafim
Doxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However, treatment with DOX is associated with cumulative cardiotoxicity inducing progressive cardiomyocyte death. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, regulates the activity of proteins involved in apoptosis, autophagy and metabolism. Our hypothesis is that pharmacological modulation by berberine (BER) pre-conditioning of Sirt3 protein levels decreases DOX-induced cardiotoxicity. Our results showed that DOX induces cell death in all experimental groups...
July 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28754835/in-vivo-functional-selection-identifies-cardiotrophin-1-as-a-cardiac-engraftment-factor-for-mesenchymal-stromal-cells
#10
Francesca Bortolotti, Giulia Ruozi, Antonella Falcione, Sara Doimo, Matteo Dal Ferro, Pierluigi Lesizza, Lorena Zentilin, Lawrence Banks, Serena Zacchigna, Mauro Giacca
Background -Transplantation of cells into the infarcted heart has significant potential to improve myocardial recovery; however, low efficacy of cell engraftment still limits therapeutic benefit. Here we describe a method for the unbiased, in vivo selection of cytokines that improve mesenchymal stromal cell (MSC) engraftment into the heart in both normal conditions and after myocardial infarction. Methods -An arrayed library of 80 secreted factors, including most of the currently known interleukins and chemokines, were individually cloned into adeno-associated viral (AAV) vectors...
July 28, 2017: Circulation
https://www.readbyqxmd.com/read/28750179/effects-of-propofol-on-conditioned-place-preference-in-male-rats-involvement-of-nitrergic-system
#11
Andleeb Shahzadi, Tuğçe Uskur, A Gökhan Akkan, Burcu Çevreli, Tayfun Uzbay
BACKGROUND: Drug-induced conditioned place preference (CPP) is linked to the addictive properties of the drug used. The number of studies that have investigated the effects of propofol on CPP is limited. Research findings suggest that nitric oxide (NO) might play an important role in substance use disorders. OBJECTIVES: The present study sought to investigate the role of the nitrergic system on the rewarding effects of propofol by using the CPP protocol in rats...
July 27, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28733950/tendon-end-separation-with-loading-in-an-achilles-tendon-repair-model-comparison-of-non-absorbable-vs-absorbable-sutures
#12
Michael R Carmont, Jan Herman Kuiper, Karin Grävare Silbernagel, Jón Karlsson, Katarina Nilsson-Helander
BACKGROUND: Rupture of the Achilles tendon often leads to long-term morbidity, particularly calf weakness associated with tendon elongation. Operative repair of Achilles tendon ruptures leads to reduced tendon elongation. Tendon lengthening is a key problem in the restoration of function following Achilles tendon rupture. A study was performed to determine differences in initial separation, strength and failure characteristics of differing sutures and numbers of core strands in a percutaneous Achilles tendon repair model in response to initial loading...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28724259/herbal-pre-conditioning-induces-proliferation-and-delays-senescence-in-wharton-s-jelly-mesenchymal-stem-cells
#13
Avinash Sanap, Bhawna Chandravanshi, Tejas Shah, Girish Tillu, Anand Dhanushkodi, Ramesh Bhonde, Kalpana Joshi
BACKGROUND: Mesenchymal Stem Cells (MSCs) are multipotent stem cells which are being explored for various clinical applications. Isolation and in-vitro expansion of MSCs remain important in achieving desired cell number for the therapy. However, in-vitro proliferation of MSCs is often associated with senescence and early onset of apoptosis which limits its therapeutic ability and long term clinical use. Tinospora cordifolia and Withania somnifera are used widely in Ayurveda: the traditional Indian system of medicine and are reported to have rejuvenating and anti-aging potential...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28711679/reproducibility-of-studies-on-text-mining-for-citation-screening-in-systematic-reviews-evaluation-and-checklist
#14
Babatunde Kazeem Olorisade, Pearl Brereton, Peter Andras
CONTEXT: Independent validation of published scientific results through study replication is a pre-condition for accepting the validity of such results. In computation research, full replication is often unrealistic for independent results validation, therefore, study reproduction has been justified as the minimum acceptable standard to evaluate the validity of scientific claims. The application of text mining techniques to citation screening in the context of systematic literature reviews is a relatively young and growing computational field with high relevance for software engineering, medical research and other fields...
July 12, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28697226/randomized-split-face-d%C3%A3-collet%C3%A3-comparative-trial-of-procedure-enhancement-system-for-fractional-non-ablative-laser-resurfacing-treatment
#15
Deanne Mraz Robinson, Ashton P Frulla
<p>INTRODUCTION: A topical proprietary procedural enhancement system (PES) containing a combination of active ingredients including a tripeptide and hexapeptide (TriHex Technology™, Alastin Procedure Enhancement Invasive System, ALASTIN Skincare™, Inc., Carlsbad, CA) has been used successfully to aid in healing and improve symptomatology following resurfacing procedures.</p> <p>METHODS: PES (Gentle Cleanser, Regenerating Skin Nectar with TriHex Technology™, Ultra Nourishing Moisturizer with TriHex Technology™, Soothe + Protect Recovery Balm, Broad Spectrum 30+ Sunscreen) was compared to a basic regimen (Aquaphor™, Cerave™ cleanser, Vanicream™, Alastin Broad Spectrum 30+ Sunscreen) in a split face/ décolleté trial following fractional non-ablative thulium-doped resurfacing treatment to the face or décolleté...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28690837/the-application-of-remote-ischemic-conditioning-in-cardiac-surgery
#16
REVIEW
Zeljko J Bosnjak, Zhi-Dong Ge
Perioperative myocardial ischemia and infarction are the leading causes of morbidity and mortality following anesthesia and surgery. The discovery of endogenous cardioprotective mechanisms has led to testing of new methods to protect the human heart. These approaches have included ischemic pre-conditioning, per-conditioning, post-conditioning, and remote conditioning of the myocardium. Pre-conditioning and per-conditioning include brief and repetitive periods of sub-lethal ischemia before and during prolonged ischemia, respectively; and post-conditioning is applied at the onset of reperfusion...
2017: F1000Research
https://www.readbyqxmd.com/read/28680375/tlr-myd88-mediated-innate-immunity-in-intestinal-graft-versus-host-disease
#17
REVIEW
Young-Kwan Lee, Myungsoo Kang, Eun Young Choi
Graft-versus-host disease (GHVD) is a severe complication after allogeneic hematopoietic stem cell transplantation. The degree of inflammation in the gastrointestinal tract, a major GVHD target organ, correlates with the disease severity. Intestinal inflammation is initiated by epithelial damage caused by pre-conditioning irradiation. In combination with damages caused by donor-derived T cells, such damage disrupts the epithelial barrier and exposes innate immune cells to pathogenic and commensal intestinal bacteria, which release ligands for Toll-like receptors (TLRs)...
June 2017: Immune Network
https://www.readbyqxmd.com/read/28680144/transplanted-adipose-derived-stem-cells-can-be-short-lived-yet-accelerate-healing-of-acid-burn-skin-wounds-a-multimodal-imaging-study
#18
Ghulam Muhammad, Jiadi Xu, Jeff W M Bulte, Anna Jablonska, Piotr Walczak, Miroslaw Janowski
The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured and without treatment options. Here, we have shown that transplantation of adipose-derived stem cells (ASCs) accelerates the process of acid burn wound-healing. Pre-conditioning of ASCs using ascorbic acid (AA) or hypoxic conditions provided additional benefit. While the wounds were ultimately healed in all mice, histological analysis revealed that, in non-transplanted animals, the number of hair follicles was reduced...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28679868/accelerated-tumor-growth-under-intermittent-hypoxia-is-associated-with-hypoxia-inducible-factor-1-dependent-adaptive-responses-to-hypoxia
#19
Dae Wui Yoon, Daeho So, Sra Min, Jiyoung Kim, Mingyu Lee, Roza Khalmuratova, Chung-Hyun Cho, Jong-Wan Park, Hyun-Woo Shin
Mounting evidence has revealed a causative role of intermittent hypoxia (IH) in cancer progression in mouse models of obstructive sleep apnea (OSA), but most studies have focused on the effects of IH following tumor implantation using an exposure to single IH frequency. Thus, we aimed to investigate 1) the potential effect of IH on the initial tumor growth in patients with OSA without an interaction with other mechanisms induced by IH in mice and 2) the influence of the IH frequency on tumor growth, which were tested using pre-conditioning with IH (Pre-IH) and 2 different IH frequencies, respectively...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28674683/infusion-of-sibling-marrow-in-a-patient-with-purine-nucleoside-phosphorylase-deficiency-leads-to-split-mixed-donor-chimerism-and-normal-immunity
#20
Laura Yeates, Mary A Slatter, Andrew R Gennery
Purine nucleoside phosphorylase (PNP) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (SCID). PNP, with adenosine deaminase (ADA), is part of the purine salvage pathway. The only curative therapy is hematopoietic stem cell transplantation. Myeloablative conditioning is recommended to prevent rejection caused by residual immune function...
2017: Frontiers in Pediatrics
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