Elizabeth Head, Heather L Murphey, Amy L S Dowling, Katie L McCarty, Samuel R Bethel, Jonathan A Nitz, Melanie Pleiss, Jenna Vanrooyen, Mike Grossheim, Jeffery R Smiley, M Paul Murphy, Tina L Beckett, Dieter Pagani, Frederick Bresch, Curt Hendrix
Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of amyloid-β (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD. Aged dogs naturally develop learning and memory impairments, human-type Aβ deposits, and oxidative damage in the brain...
2012: Journal of Alzheimer's Disease: JAD