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alpha lipoic acid, memory

Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Germana Silva Vasconcelos, Ingridy da Silva Medeiros, Márcia Calheiros Chaves Silva, Fayçal Mouaffak, Oussama Kebir, Cláudio Manuel Gonçalves da Silva Leite, Manoel Cláudio Azevedo Patrocinio, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when combined to antidepressants. Female mice received vehicle or corticosterone (CORT) 20 mg/kg, s.c. for 14 days. From the 15th to 21st day, the animals were divided in groups: vehicle, CORT, CORT+desvenlafaxine (DVS) 10 or 20 mg/kg, ALA 100 or 200 mg/kg, DVS10+ALA100, DVS20+ALA100, DVS10+ALA200, or DVS20+ALA200. Tail suspension (TST), social interaction (SIT), novel object recognition (NOR), and Y-maze tests were conducted...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Luis Rafael Leite Sampaio, Francisco Maurício Sales Cysne Filho, Jamily Cunha de Almeida, Danilo Dos Santos Diniz, Cláudio Felipe Vasconcelos Patrocínio, Caren Nádia Soares de Sousa, Manoel Cláudio Azevedo Patrocínio, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos
Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats...
March 1, 2018: Neuroscience
Laura E Villasana, Tunde Akinyeke, Sydney Weber, Jacob Raber
In humans, apoE, which plays a role in repair, is expressed in three isoforms: E2, E3, and E4. E4 is a risk factor for age-related cognitive decline (ACD) and Alzheimer's disease (AD), particularly in women. In contrast, E2 is a protective factor for ACD and AD. E2 and E4 might also differ in their response to cranial137 Cs irradiation, a form of radiation typically used in a clinical setting for the treatment of cancer. This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion...
September 29, 2017: Oncotarget
Aamra Mahboob, Syeda Mehpara Farhat, Ghazala Iqbal, Mustafeez Mujtaba Babar, Najam-us-Sahar Sadaf Zaidi, Seyed Mohammad Nabavi, Touqeer Ahmed
Aluminum (Al) is a neurotoxic agent which readily crosses the blood-brain-barrier (BBB) and accumulates in the brain leading to neurodegenerative disorders, characterised by cognitive impairment. Alpha-lipoic acid (ALA) is an antioxidant and has a potential to improve cognitive functions. This study aimed to evaluate the neuroprotective effect of ALA in AlCl3-induced neurotoxicity mouse model. Effect of ALA (25mg/kg/day) was evaluated in the AlCl3-induced neurotoxicity (AlCl3 150 mg/kg/day) mouse model on learning and memory using behaviour tests and on the expression of muscarinic receptor genes (using RT-PCR), in hippocampus and amygdala...
April 2016: Brain Research Bulletin
Beatrice Bortolato, Kamilla W Miskowiak, Cristiano A Köhler, Michael Maes, Brisa S Fernandes, Michael Berk, André F Carvalho
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD...
January 22, 2016: BMC Medicine
Arpit Mehrotra, Abhilasha Sood, Rajat Sandhir
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of succinate dehydrogenase and induces neuropathological changes similar to those observed in Huntington's disease (HD). The objective of the present study was to investigate neuroprotective effect of mitochondrial modulators; alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALCAR) on 3-NP-induced alterations in mitochondrial lipid composition, mitochondrial structure and memory functions. Experimental model of HD was developed by administering 3-NP at sub-chronic doses, twice daily for 17 days...
December 2015: Molecular and Cellular Biochemistry
Maha A E Ahmed, Sally A El-Awdan
Behavioral perturbations associated with nandrolone decanoate abuse by athletes and adolescents may be attributed to oxidative stress and inflammation. However, the underlying mechanisms are not yet fully explored. On the other hand, the natural antioxidant lipoic acid can pass the blood brain barrier and enhance Nrf2/HO-1 (nuclear factor erythroid-2 related factor 2/heme oxygenase-1) pathway. In addition, the phosphodiesterase-IV inhibitor xanthine derivative pentoxifylline has a remarkable inhibitory effect on tumor necrosis factor-alpha (TNF-α)...
July 2015: Hormones and Behavior
Germana Silva Vasconcelos, Naiara Coelho Ximenes, Caren Nádia Soares de Sousa, Tatiana de Queiroz Oliveira, Laio Ladislau Lopes Lima, David Freitas de Lucena, Clarissa Severino Gama, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos
Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of schizophrenia-like alterations induced by ketamine (KET). Adult male mice received saline or KET for 14 days. From 8th to 14th days mice were additionally administered saline, ALA (100 mg/kg), CLZ 2.5 or 5 mg/kg or the combinations ALA+CLZ2.5 or ALA+CLZ5. Schizophrenia-like symptoms were evaluated by prepulse inhibition of the startle (PPI) and locomotor activity (positive-like), social preference (negative-like) and Y maze (cognitive-like)...
July 2015: Schizophrenia Research
Ran-Ran Zhao, Fei Xu, Xiao-Chen Xu, Guo-Jun Tan, Liang-Min Liu, Ning Wu, Wen-Zhong Zhang, Ji-Xiang Liu
Brain oxidative stress due to chronic cerebral hypoperfusion was considered to be the major risk factor in the pathogenesis of vascular dementia. In this study, we investigated the protective efficacy of alpha-lipoic acid, an antioxidant, against vascular dementia in rats, as well as the potential mechanism. Bilateral common carotid arteries occlusion (BCCAO) induced severe cognitive deficits tested by Morris water maze (MWM), along with oxidative stress and disturbance of central cholinergic system. However, administration of alpha-lipoic acid (50mg/kg, i...
February 5, 2015: Neuroscience Letters
Ishita Guha Thakurta, Priyanjalee Banerjee, Maria Bindu Bagh, Arindam Ghosh, Arghyadip Sahoo, Sita Chattopadhyay, Sasanka Chakrabarti
This study has compared several synaptosomal parameters in three groups of rats: young (46 months), aged (22-24 months) and antioxidant supplemented aged rats (antioxidant supplementation given with the diet as a combination of N-acetylcysteine, α-lipoic acid and α-tocopherol from 18 months onwards till 22-24 months). The synaptosomes from aged rat brain, in comparison to those of young animals, exhibit an increased membrane potential with altered contents of Na(+) and K(+) under basal incubation condition and in the presence of depolarizing agents...
February 2014: Experimental Gerontology
Gwendolen E Haley, Lauren Yeiser, Reid H J Olsen, Matthew J Davis, Lance A Johnson, Jacob Raber
Relatively little is known about early irradiation effects on hippocampal function in wild-type mice. In this study, the effects of (56)Fe irradiation on hippocampal function were assessed starting 2 weeks after whole-body irradiation. Compared to sham irradiation, radiation impaired novel object recognition in female and male C57BL/6J wild-type mice. There were no effects of irradiation on contextual fear conditioning or spatial memory retention in the water maze. It is possible that oxidative damage might contribute to radiation-induced cognitive changes...
May 2013: Radiation Research
Laura E Villasana, Rosalind A Rosenthal, Susan R Doctrow, Timothy Pfankuch, Damian G Zuloaga, Alexandra Maccoll Garfinkel, Jacob Raber
Cranial irradiation with (56)Fe, a form of space radiation, causes hippocampus-dependent cognitive changes. (56)Fe irradiation also increases reactive oxygen species (ROS) levels, which may contribute to these changes. Therefore, we investigated the effects of the antioxidant alpha lipoic acid (ALA) on cognition following sham-irradiation and irradiation. Male mice were irradiated (brain only) with (56)Fe (3 Gy) or sham-irradiated at 6-9 months of age. Half of the mice remained fed a regular chow and the other half of the mice were fed a caloric-matched diet containing ALA starting two-weeks prior to irradiation and throughout cognitive testing...
January 2013: Pharmacology, Biochemistry, and Behavior
Elizabeth Head, Heather L Murphey, Amy L S Dowling, Katie L McCarty, Samuel R Bethel, Jonathan A Nitz, Melanie Pleiss, Jenna Vanrooyen, Mike Grossheim, Jeffery R Smiley, M Paul Murphy, Tina L Beckett, Dieter Pagani, Frederick Bresch, Curt Hendrix
Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of amyloid-β (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD. Aged dogs naturally develop learning and memory impairments, human-type Aβ deposits, and oxidative damage in the brain...
2012: Journal of Alzheimer's Disease: JAD
Susan A Farr, Tulin O Price, William A Banks, Nuran Ercal, John E Morley
Oxidative damage is associated with neurodegenerative disorders such as Alzheimer's disease (AD). The antioxidant alpha-lipoic acid has been found to improve memory in mouse models of AD. Here, we administered alpha-lipoic acid daily to SAMP8 mice starting at 11 months of age and continuing until death. We found that treatment with alpha-lipoic acid decreased survival from 34 weeks in those receiving vehicle to 20 weeks. A subset of 18 month old mice given alpha-lipoic acid for two weeks and then tested in an object-place recognition paradigm had improved memory...
2012: Journal of Alzheimer's Disease: JAD
Daniel G Amen, Joseph C Wu, Derek Taylor, Kristen Willeumier
Brain injuries are common in professional American football players. Finding effective rehabilitation strategies can have widespread implications not only for retired players but also for patients with traumatic brain injury and substance abuse problems. An open label pragmatic clinical intervention was conducted in an outpatient neuropsychiatric clinic with 30 retired NFL players who demonstrated brain damage and cognitive impairment. The study included weight loss (if appropriate); fish oil (5.6 grams a day); a high-potency multiple vitamin; and a formulated brain enhancement supplement that included nutrients to enhance blood flow (ginkgo and vinpocetine), acetylcholine (acetyl-l-carnitine and huperzine A), and antioxidant activity (alpha-lipoic acid and n-acetyl-cysteine)...
January 2011: Journal of Psychoactive Drugs
A Di Stefano, P Sozio, L S Cerasa, A Iannitelli, A Cataldi, S Zara, G Giorgioni, C Nasuti
Both oxidative stress and inflammation are elevated in brains of Alzheimer's disease patients, but their pathogenic significance still remains unclear. Current evidence support the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) and antioxidant therapy might protect against the development of Alzheimer's disease, and ibuprofen has the strongest epidemiological support. In the present work our attention was focused on (R)-alpha-lipoic acid considered as a potential neuroprotective agent in Alzheimer's disease therapy...
April 2010: International Journal of Immunopathology and Pharmacology
Xue-bo Lin, Bo Zhou, Fang Sun, Fang-fang Chen
OBJECTIVE: To investigate the roles of protein kinase C (PKC) beta(2) and reactive oxygen species (ROS) in the mRNA expression of vascular endothelial growth factor(VEGF) and vascular cell adhesion molecule-1(VCAM-1) in human umbilical vein endothelial cells (HUVECs), imitating 'hyperglycemic memory' in vitro and the relationship between them. METHODS: The HUVECs were divided into 5 groups: normal glucose (NG, D-glucose 5 mmol/L x 3 weeks) group, high glucose (HG, D-glucose 25 mmol/L x 3 weeks) group, memory (M, 25 mmol/L D-glucose x 2 weeks + 5 mmol/L D-glucose x 1 weeks) group, memory transfected with PKCbeta(2) (MB, M + Ad5-PKCbeta(2)) group, memory plus alpha-lipoic acid (MA, M + 62...
March 2010: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Joon Y Cho, Hyun S Um, Eun B Kang, In H Cho, Chul H Kim, Jung S Cho, Dae Y Hwang
Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/APPsw Tg mice were treated with alpha-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred...
March 2010: International Journal of Molecular Medicine
Justin C Shenk, Jiankang Liu, Kathryn Fischbach, Kui Xu, Michel Puchowicz, Mark E Obrenovich, Eldar Gasimov, Ludis Morales Alvarez, Bruce N Ames, Joseph C Lamanna, Gjumrakch Aliev
We measured age-dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age-matched wild-type (WT) mice by use of [(14)C] iodoantipyrene autoradiography. ApoE4 associated factors reduce CBF gradually to create brain hypoperfusion when compared to WT, and the differences in CBF are greatest as animals age from 6-weeks to 12-months. Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells...
August 15, 2009: Journal of the Neurological Sciences
Annette Maczurek, Klaus Hager, Marlene Kenklies, Matt Sharman, Ralph Martins, Jürgen Engel, David A Carlson, Gerald Münch
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment - particularly for the early stages of disease - remains unavailable for clinical use. In this review, we advance the suggestion that lipoic acid (LA) may fulfil this therapeutic need. A naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, LA has been shown to have a variety of properties which can interfere with the pathogenesis or progression of AD...
October 2008: Advanced Drug Delivery Reviews
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