keyword
MENU ▼
Read by QxMD icon Read
search

alpha lipoic acid, memory

keyword
https://www.readbyqxmd.com/read/26912408/alpha-lipoic-acid-mediated-activation-of-muscarinic-receptors-improves-hippocampus-and-amygdala-dependent-memory
#1
Aamra Mahboob, Syeda Mehpara Farhat, Ghazala Iqbal, Mustafeez Mujtaba Babar, Najam-us-Sahar Sadaf Zaidi, Seyed Mohammad Nabavi, Touqeer Ahmed
Aluminum (Al) is a neurotoxic agent which readily crosses the blood-brain-barrier (BBB) and accumulates in the brain leading to neurodegenerative disorders, characterised by cognitive impairment. Alpha-lipoic acid (ALA) is an antioxidant and has a potential to improve cognitive functions. This study aimed to evaluate the neuroprotective effect of ALA in AlCl3-induced neurotoxicity mouse model. Effect of ALA (25mg/kg/day) was evaluated in the AlCl3-induced neurotoxicity (AlCl3 150 mg/kg/day) mouse model on learning and memory using behaviour tests and on the expression of muscarinic receptor genes (using RT-PCR), in hippocampus and amygdala...
April 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26801406/cognitive-remission-a-novel-objective-for-the-treatment-of-major-depression
#2
REVIEW
Beatrice Bortolato, Kamilla W Miskowiak, Cristiano A Köhler, Michael Maes, Brisa S Fernandes, Michael Berk, André F Carvalho
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD...
January 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/26374445/mitochondrial-modulators-improve-lipid-composition-and-attenuate-memory-deficits-in-experimental-model-of-huntington-s-disease
#3
COMPARATIVE STUDY
Arpit Mehrotra, Abhilasha Sood, Rajat Sandhir
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of succinate dehydrogenase and induces neuropathological changes similar to those observed in Huntington's disease (HD). The objective of the present study was to investigate neuroprotective effect of mitochondrial modulators; alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALCAR) on 3-NP-induced alterations in mitochondrial lipid composition, mitochondrial structure and memory functions. Experimental model of HD was developed by administering 3-NP at sub-chronic doses, twice daily for 17 days...
December 2015: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26187709/lipoic-acid-and-pentoxifylline-mitigate-nandrolone-decanoate-induced-neurobehavioral-perturbations-in-rats-via-re-balance-of-brain-neurotransmitters-up-regulation-of-nrf2-ho-1-pathway-and-down-regulation-of-tnfr1-expression
#4
Maha A E Ahmed, Sally A El-Awdan
Behavioral perturbations associated with nandrolone decanoate abuse by athletes and adolescents may be attributed to oxidative stress and inflammation. However, the underlying mechanisms are not yet fully explored. On the other hand, the natural antioxidant lipoic acid can pass the blood brain barrier and enhance Nrf2/HO-1 (nuclear factor erythroid-2 related factor 2/heme oxygenase-1) pathway. In addition, the phosphodiesterase-IV inhibitor xanthine derivative pentoxifylline has a remarkable inhibitory effect on tumor necrosis factor-alpha (TNF-α)...
July 2015: Hormones and Behavior
https://www.readbyqxmd.com/read/25937462/alpha-lipoic-acid-alone-and-combined-with-clozapine-reverses-schizophrenia-like-symptoms-induced-by-ketamine-in-mice-participation-of-antioxidant-nitrergic-and-neurotrophic-mechanisms
#5
Germana Silva Vasconcelos, Naiara Coelho Ximenes, Caren Nádia Soares de Sousa, Tatiana de Queiroz Oliveira, Laio Ladislau Lopes Lima, David Freitas de Lucena, Clarissa Severino Gama, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos
Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a natural antioxidant synthesized in human tissues with clinical uses. We studied the effect of ALA or clozapine (CLZ) alone or in combination in the reversal of schizophrenia-like alterations induced by ketamine (KET). Adult male mice received saline or KET for 14 days. From 8th to 14th days mice were additionally administered saline, ALA (100 mg/kg), CLZ 2.5 or 5 mg/kg or the combinations ALA+CLZ2.5 or ALA+CLZ5. Schizophrenia-like symptoms were evaluated by prepulse inhibition of the startle (PPI) and locomotor activity (positive-like), social preference (negative-like) and Y maze (cognitive-like)...
July 2015: Schizophrenia Research
https://www.readbyqxmd.com/read/25534501/effects-of-alpha-lipoic-acid-on-spatial-learning-and-memory-oxidative-stress-and-central-cholinergic-system-in-a-rat-model-of-vascular-dementia
#6
Ran-Ran Zhao, Fei Xu, Xiao-Chen Xu, Guo-Jun Tan, Liang-Min Liu, Ning Wu, Wen-Zhong Zhang, Ji-Xiang Liu
Brain oxidative stress due to chronic cerebral hypoperfusion was considered to be the major risk factor in the pathogenesis of vascular dementia. In this study, we investigated the protective efficacy of alpha-lipoic acid, an antioxidant, against vascular dementia in rats, as well as the potential mechanism. Bilateral common carotid arteries occlusion (BCCAO) induced severe cognitive deficits tested by Morris water maze (MWM), along with oxidative stress and disturbance of central cholinergic system. However, administration of alpha-lipoic acid (50mg/kg, i...
February 5, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/24291247/combination-of-n-acetylcysteine-%C3%AE-lipoic-acid-and-%C3%AE-tocopherol-substantially-prevents-the-brain-synaptosomal-alterations-and-memory-and-learning-deficits-of-aged-rats
#7
Ishita Guha Thakurta, Priyanjalee Banerjee, Maria Bindu Bagh, Arindam Ghosh, Arghyadip Sahoo, Sita Chattopadhyay, Sasanka Chakrabarti
This study has compared several synaptosomal parameters in three groups of rats: young (46 months), aged (22-24 months) and antioxidant supplemented aged rats (antioxidant supplementation given with the diet as a combination of N-acetylcysteine, α-lipoic acid and α-tocopherol from 18 months onwards till 22-24 months). The synaptosomes from aged rat brain, in comparison to those of young animals, exhibit an increased membrane potential with altered contents of Na(+) and K(+) under basal incubation condition and in the presence of depolarizing agents...
February 2014: Experimental Gerontology
https://www.readbyqxmd.com/read/23510274/early-effects-of-whole-body-56-fe-irradiation-on-hippocampal-function-in-c57bl-6j-mice
#8
Gwendolen E Haley, Lauren Yeiser, Reid H J Olsen, Matthew J Davis, Lance A Johnson, Jacob Raber
Relatively little is known about early irradiation effects on hippocampal function in wild-type mice. In this study, the effects of (56)Fe irradiation on hippocampal function were assessed starting 2 weeks after whole-body irradiation. Compared to sham irradiation, radiation impaired novel object recognition in female and male C57BL/6J wild-type mice. There were no effects of irradiation on contextual fear conditioning or spatial memory retention in the water maze. It is possible that oxidative damage might contribute to radiation-induced cognitive changes...
May 2013: Radiation Research
https://www.readbyqxmd.com/read/23051895/effects-of-alpha-lipoic-acid-on-associative-and-spatial-memory-of-sham-irradiated-and-56fe-irradiated-c57bl-6j-male-mice
#9
Laura E Villasana, Rosalind A Rosenthal, Susan R Doctrow, Timothy Pfankuch, Damian G Zuloaga, Alexandra Maccoll Garfinkel, Jacob Raber
Cranial irradiation with (56)Fe, a form of space radiation, causes hippocampus-dependent cognitive changes. (56)Fe irradiation also increases reactive oxygen species (ROS) levels, which may contribute to these changes. Therefore, we investigated the effects of the antioxidant alpha lipoic acid (ALA) on cognition following sham-irradiation and irradiation. Male mice were irradiated (brain only) with (56)Fe (3 Gy) or sham-irradiated at 6-9 months of age. Half of the mice remained fed a regular chow and the other half of the mice were fed a caloric-matched diet containing ALA starting two-weeks prior to irradiation and throughout cognitive testing...
January 2013: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/22886019/a-combination-cocktail-improves-spatial-attention-in-a-canine-model-of-human-aging-and-alzheimer-s-disease
#10
Elizabeth Head, Heather L Murphey, Amy L S Dowling, Katie L McCarty, Samuel R Bethel, Jonathan A Nitz, Melanie Pleiss, Jenna Vanrooyen, Mike Grossheim, Jeffery R Smiley, M Paul Murphy, Tina L Beckett, Dieter Pagani, Frederick Bresch, Curt Hendrix
Alzheimer's disease (AD) involves multiple pathological processes in the brain, including increased inflammation and oxidative damage, as well as the accumulation of amyloid-β (Aβ) plaques. We hypothesized that a combinatorial therapeutic approach to target these multiple pathways may provide cognitive and neuropathological benefits for AD patients. To test this hypothesis, we used a canine model of human aging and AD. Aged dogs naturally develop learning and memory impairments, human-type Aβ deposits, and oxidative damage in the brain...
2012: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/22785389/effect-of-alpha-lipoic-acid-on-memory-oxidation-and-lifespan-in-samp8-mice
#11
Susan A Farr, Tulin O Price, William A Banks, Nuran Ercal, John E Morley
Oxidative damage is associated with neurodegenerative disorders such as Alzheimer's disease (AD). The antioxidant alpha-lipoic acid has been found to improve memory in mouse models of AD. Here, we administered alpha-lipoic acid daily to SAMP8 mice starting at 11 months of age and continuing until death. We found that treatment with alpha-lipoic acid decreased survival from 34 weeks in those receiving vehicle to 20 weeks. A subset of 18 month old mice given alpha-lipoic acid for two weeks and then tested in an object-place recognition paradigm had improved memory...
2012: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/21615001/reversing-brain-damage-in-former-nfl-players-implications-for-traumatic-brain-injury-and-substance-abuse-rehabilitation
#12
Daniel G Amen, Joseph C Wu, Derek Taylor, Kristen Willeumier
Brain injuries are common in professional American football players. Finding effective rehabilitation strategies can have widespread implications not only for retired players but also for patients with traumatic brain injury and substance abuse problems. An open label pragmatic clinical intervention was conducted in an outpatient neuropsychiatric clinic with 30 retired NFL players who demonstrated brain damage and cognitive impairment. The study included weight loss (if appropriate); fish oil (5.6 grams a day); a high-potency multiple vitamin; and a formulated brain enhancement supplement that included nutrients to enhance blood flow (ginkgo and vinpocetine), acetylcholine (acetyl-l-carnitine and huperzine A), and antioxidant activity (alpha-lipoic acid and n-acetyl-cysteine)...
January 2011: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/20646354/ibuprofen-and-lipoic-acid-diamide-as-co-drug-with-neuroprotective-activity-pharmacological-properties-and-effects-in-beta-amyloid-1-40-infused-alzheimer-s-disease-rat-model
#13
A Di Stefano, P Sozio, L S Cerasa, A Iannitelli, A Cataldi, S Zara, G Giorgioni, C Nasuti
Both oxidative stress and inflammation are elevated in brains of Alzheimer's disease patients, but their pathogenic significance still remains unclear. Current evidence support the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) and antioxidant therapy might protect against the development of Alzheimer's disease, and ibuprofen has the strongest epidemiological support. In the present work our attention was focused on (R)-alpha-lipoic acid considered as a potential neuroprotective agent in Alzheimer's disease therapy...
April 2010: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/20450659/-hyperglycaemic-memory-in-human-umbilical-vein-endothelial-cells-mediated-by-interacting-loop-of-protein-kinase-cbeta-2-reactive-oxygen-species
#14
Xue-bo Lin, Bo Zhou, Fang Sun, Fang-fang Chen
OBJECTIVE: To investigate the roles of protein kinase C (PKC) beta(2) and reactive oxygen species (ROS) in the mRNA expression of vascular endothelial growth factor(VEGF) and vascular cell adhesion molecule-1(VCAM-1) in human umbilical vein endothelial cells (HUVECs), imitating 'hyperglycemic memory' in vitro and the relationship between them. METHODS: The HUVECs were divided into 5 groups: normal glucose (NG, D-glucose 5 mmol/L x 3 weeks) group, high glucose (HG, D-glucose 25 mmol/L x 3 weeks) group, memory (M, 25 mmol/L D-glucose x 2 weeks + 5 mmol/L D-glucose x 1 weeks) group, memory transfected with PKCbeta(2) (MB, M + Ad5-PKCbeta(2)) group, memory plus alpha-lipoic acid (MA, M + 62...
March 2010: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/20127037/the-combination-of-exercise-training-and-alpha-lipoic-acid-treatment-has-therapeutic-effects-on-the-pathogenic-phenotypes-of-alzheimer-s-disease-in-nse-appsw-transgenic-mice
#15
Joon Y Cho, Hyun S Um, Eun B Kang, In H Cho, Chul H Kim, Jung S Cho, Dae Y Hwang
Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study. Therefore, the purpose of this study was to investigate the effects of combining exercise training with the administration of antioxidants on the pathological phenotype of AD. To accomplish this, non-transgenic mice (Non-Tg) and NSE/APPsw Tg mice were treated with alpha-lipoic acid and treadmill exercised for 16 weeks, after which their brains were evaluated to determine whether any changes in the pathological phenotype-related factors occurred...
March 2010: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/19342064/the-effect-of-acetyl-l-carnitine-and-r-alpha-lipoic-acid-treatment-in-apoe4-mouse-as-a-model-of-human-alzheimer-s-disease
#16
Justin C Shenk, Jiankang Liu, Kathryn Fischbach, Kui Xu, Michel Puchowicz, Mark E Obrenovich, Eldar Gasimov, Ludis Morales Alvarez, Bruce N Ames, Joseph C Lamanna, Gjumrakch Aliev
We measured age-dependent effects of human ApoE4 on cerebral blood flow (CBF) using ApoE4 transgenic mice compared to age-matched wild-type (WT) mice by use of [(14)C] iodoantipyrene autoradiography. ApoE4 associated factors reduce CBF gradually to create brain hypoperfusion when compared to WT, and the differences in CBF are greatest as animals age from 6-weeks to 12-months. Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells...
August 15, 2009: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/18655815/lipoic-acid-as-an-anti-inflammatory-and-neuroprotective-treatment-for-alzheimer-s-disease
#17
REVIEW
Annette Maczurek, Klaus Hager, Marlene Kenklies, Matt Sharman, Ralph Martins, Jürgen Engel, David A Carlson, Gerald Münch
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that destroys patient memory and cognition, communication ability with the social environment and the ability to carry out daily activities. Despite extensive research into the pathogenesis of AD, a neuroprotective treatment - particularly for the early stages of disease - remains unavailable for clinical use. In this review, we advance the suggestion that lipoic acid (LA) may fulfil this therapeutic need. A naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, LA has been shown to have a variety of properties which can interfere with the pathogenesis or progression of AD...
October 2008: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/18006086/memory-impairment-oxidative-damage-and-apoptosis-induced-by-space-radiation-ameliorative-potential-of-alpha-lipoic-acid
#18
Kailash Manda, Megumi Ueno, Kazunori Anzai
Exposure to high-energy particle radiation (HZE) may cause oxidative stress and cognitive impairment in the same manner that seen in aged mice. This phenomenon has raised the concerns about the safety of an extended manned mission into deep space where a significant portion of the radiation burden would come from HZE particle radiation. The present study aimed at investigating the role of alpha-lipoic acid against space radiation-induced oxidative stress and antioxidant status in cerebellum and its correlation with cognitive dysfunction...
March 5, 2008: Behavioural Brain Research
https://www.readbyqxmd.com/read/17622567/acetyl-l-carnitine-and-alpha-lipoic-acid-supplementation-of-aged-beagle-dogs-improves-learning-in-two-landmark-discrimination-tests
#19
N W Milgram, J A Araujo, T M Hagen, B V Treadwell, B N Ames
Beagle dogs between 7.6 and 8.8 years of age administered a twice daily supplement of alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC) over approximately 2 months made significantly fewer errors in reaching the learning criterion on two landmark discrimination tasks compared to controls administered a methylcellulose placebo. Testing started after a 5 day wash-in. The dogs were also tested on a variable delay version of a previously acquired spatial memory task; results were not significant. The improved performance on the landmark task of dogs supplemented with LA + ALC provides evidence of the effectiveness of this supplement in improving discrimination and allocentric spatial learning...
November 2007: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/17605107/the-effects-and-mechanisms-of-mitochondrial-nutrient-alpha-lipoic-acid-on-improving-age-associated-mitochondrial-and-cognitive-dysfunction-an-overview
#20
REVIEW
Jiankang Liu
We have identified a group of nutrients that can directly or indirectly protect mitochondria from oxidative damage and improve mitochondrial function and named them "mitochondrial nutrients". The direct protection includes preventing the generation of oxidants, scavenging free radicals or inhibiting oxidant reactivity, and elevating cofactors of defective mitochondrial enzymes with increased Michaelis-Menten constant to stimulate enzyme activity, and also protect enzymes from further oxidation, and the indirect protection includes repairing oxidative damage by enhancing antioxidant defense systems either through activation of phase 2 enzymes or through increase in mitochondrial biogenesis...
January 2008: Neurochemical Research
keyword
keyword
80131
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"