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https://www.readbyqxmd.com/read/27933491/nlrp3-is-required-for-complement-mediated-caspase-1-and-il-1beta-activation-in-ich-short-title-for-running-head-nlrp3-is-required-for-ich
#1
Sheng-Tao Yao, Fang Cao, Jia-Lin Chen, Wei Chen, Rui-Ming Fan, Gang Li, You-Chao Zeng, Song Jiao, Xiang-Ping Xia, Chong Han, Qi-Shan Ran
Complement-mediated inflammation plays a vital role in intracerebral hemorrhage (ICH), implicating pro-inflammatory factor interleukin-1beta (IL-1β) secretion. Brain samples and contralateral hemiencephalon were all collected and detected by Western blot. NLRP3 expression was located by dual immunofluorescence staining at 1, 3, and 5 days post-ICH. Brain water content was examined post-ICH. The neural deficit scores were evaluated by observers blindly. ILs were detected by ELISA. SiRNAs targeting NLRP3 (siNLRP3), siASC, and siControl were injected to inhibit NLRP3 function...
December 8, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27933424/-home-practice-is-the-program-parents-practice-of-program-skills-as-predictors-of-outcomes-in-the-new-beginnings-program-effectiveness-trial
#2
Cady Berkel, Irwin N Sandler, Sharlene A Wolchik, C Hendricks Brown, Carlos G Gallo, Amanda Chiapa, Anne M Mauricio, Sarah Jones
An examination of the content and processes of evidence-based programs is critical for empirically evaluating theories about how programs work, the "action theory" of the program (West et al. in American Journal of Community Psychology, 21, 571-605, 1993). The New Beginnings Program (NBP; Wolchik et al., 2007), a parenting-after-divorce preventive intervention, theorizes that program-induced improvements in parenting across three domains: positive relationship quality, effective discipline, and protecting children from interparental conflict, will reduce the negative outcomes that are common among children from divorced families...
December 8, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27932860/rebound-macular-edema-following-oral-acetazolamide-therapy-for-juvenile-x-linked-retinoschisis-in-an-italian-family
#3
Maria Silvana Galantuomo, Maurizio Fossarello, Alberto Cuccu, Roberta Farci, Markus N Preising, Birgit Lorenz, Pietro Emanuele Napoli
BACKGROUND: Juvenile X-linked retinoschisis (RS1, OMIM: 312700) is a hereditary vitreoretinal dystrophy characterized by bilateral foveal schisis and, in half of the patients, splitting through the nerve fiber layer in the peripheral retina. In the first decade of life, patients usually develop a decrease in visual acuity. Long-term visual outcomes can be poor due to the limited number of known successful treatments. PURPOSE: The purposes of this study were to present, for the first time, a p...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27932597/parent-experience-of-neonatal-encephalopathy-the-need-for-family-centered-outcomes
#4
Monica E Lemmon, Pamela K Donohue, Charlamaine Parkinson, Frances J Northington, Renee D Boss
We aimed to characterize the parent experience of caring for an infant with neonatal encephalopathy. In this mixed-methods study, we performed semistructured interviews with parents whose infants were enrolled in an existing longitudinal cohort study of therapeutic hypothermia between 2011 and 2014. Thematic saturation was achieved after 20 interviews. Parent experience of caring for a child with neonatal encephalopathy was characterized by 3 principal themes. Theme 1: Many families described cumulative loss and grief throughout the perinatal crisis, critical neonatal course, and subsequent missed developmental milestones...
December 8, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27932588/mental-health-among-jail-and-prison-inmates
#5
Youngmin Yi, Kristin Turney, Christopher Wildeman
Previous studies provide insight into the mental health of jail and prison inmates, but this research does not compare the two groups of inmates. Using data from the Fragile Families and Child Wellbeing Study, this article examines how the association between incarceration and self-reported mental health varies by facility type, net of an array of demographic and socioeconomic characteristics. Both jail and prison inmates report high rates of depression, life dissatisfaction, heavy drinking, and illicit drug use...
December 7, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27932550/spermaurin-an-la1-like-peptide-from-the-venom-of-the-scorpion-scorpio-maurus-palmatus-improves-sperm-motility-and-fertilization-in-different-mammalian-species
#6
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932092/quality-assessment-of-postmortem-tissue-donors-in-a-university-hospital-detection-and-generation-tissue-indicators
#7
R Roque, C Rodriguez-Villar, A Ruiz, D Paredes, R Gelpi, X Garcia, F Vizcaíno, S Saavedra, S Rodríguez, M Quijada, M Bohils, R Adalia
BACKGROUND: Defining quality assessment and measurement tools in the area of tissue donation should be considered to be one of the most important strategies for developing health centers. The aim of this project was to identify, define, and analyze a set of indicators to assess the most important steps in the tissue donor detection and generation processes. METHODS: A prospective, descriptive, and comparative study of all potential tissue donors (TDs) detected and generated in a university hospital was performed...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932011/child-physical-development-in-the-uk-the-imprint-of-time-and-socioeconomic-status
#8
B H Apouey
OBJECTIVES: Social health inequalities remain a key policy challenge. The existing literature has not presented a synthetic view on the evolution of inequalities in physical development across childhood. We examine social disparities as children grow older using a range of different outcomes. STUDY DESIGN: Population-based secondary data analysis. METHODS: We employ longitudinal data on British children aged 9 months to 12 years from the Millennium Cohort Study (n = 13,811-18,987) and focus on multiple child physical measures: weight, body mass index (BMI), overweight, fat mass and waist circumference...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931859/contemporary-trends-in-the-management-and-outcomes-of-patients-with-familial-hypercholesterolemia-in-canada-a%C3%A2-prospective-observational-study
#9
Liam R Brunham, Lubomira Cermakova, Terry Lee, Ida Priecelova, Karine Alloul, Marilyn de Chantal, Gordon A Francis, Jiri Frohlich
BACKGROUND: Heterozygous familial hypercholesterolemia (HeFH) is one of the most common genetic diseases in the world and an important cause of premature cardiovascular (CV) disease. The purpose of this study was to characterize the clinical features, current treatment patterns, and CV outcomes of patients with HeFH in British Columbia, Canada. METHODS: We conducted a longitudinal observational study of patients with HeFH attending a specialized lipid clinic. We collected data on lipid levels, medication use, and CV events at baseline and last follow-up...
September 3, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27931573/survival-predictors-in-liver-transplantation-time-varying-effect-of-red-blood-cell-transfusion
#10
C Real, D Sobreira Fernandes, P Sá Couto, F Correia de Barros, S Esteves, I Aragão, L Fonseca, J Aguiar, T Branco, Z Fernandes Moreira
BACKGROUND: Many attempts have been undertaken to better predict outcome after liver transplantation. The aim of this study was to identify the pre- and intraoperative variables that may influence the survival after liver transplantation, at a single institution. METHODS: Anesthetic records from 543 consecutive patients who underwent liver transplantation from June 2006 to June 2014 were reviewed in this retrospective study. Patients undergoing retransplantation were excluded from the analysis, as were patients with familial amyloid polyneuropathy...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931533/care-transition-interventions-for-children-with-asthma-in-the-emergency-department
#11
REVIEW
Molly A Martin, Valerie G Press, Sharmilee M Nyenhuis, Jerry A Krishnan, Kim Erwin, Giselle Mosnaim, Helen Margellos-Anast, S Margaret Paik, Stacy Ignoffo, Michael McDermott
The emergency department (ED) is a critical point of identification and treatment for some of the most high-risk children with asthma. This review summarizes the evidence regarding care transition interventions originating in the ED for children with uncontrolled asthma, with a focus on care coordination and self-management education. Although many interventions on care transition for pediatric asthma have been tested, only a few were actually conducted in the ED setting. Most of these targeted both care coordination and self-management education but ultimately did not improve attendance at follow-up appointments with primary care providers, improve asthma control, or reduce health care utilization...
December 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27931124/the-contribution-of-role-satisfaction-meaning-in-life-and-work-home-conflict-to-explaining-well-being-among-working-grandparents
#12
Liat Kulik, Sagit Shilo-Levin, Gabriel Liberman
BACKGROUND AND OBJECTIVES: The study aimed to examine the relationship of satisfaction with occupied roles as well as the sense of meaning in life and experience of work-home conflict to well-being among working grandparents in Israel. DESIGN AND METHODS: The research sample consisted of 316 employed grandparents aged 50-80 (153 grandfathers, and 163 grandmothers), who were employed in various types of organizations. Data were collected using structured questionnaires...
December 8, 2016: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/27931090/prenatal-diagnosis-of-susceptibility-loci-for-neurodevelopmental-disorders-genetic-counseling-and-pregnancy-outcome-in-57-cases
#13
Lutgarde Govaerts, Malgorzata Srebniak, Karin Diderich, Marieke Joosten, Sam Riedijk, Maarten Knapen, Attie Go, Dimitri Papatsonis, Katja de Graaf, Toon Toolenaar, Sanne van der Steen, Gido Huijbregts, Jeroen Knijnenburg, Femke de Vries, Diane Van Opstal, Robert-Jan Galjaard
BACKGROUND: Whole genome array testing not only provides an increased diagnostic yield of pathogenic causative findings, but it may also reveal so called susceptibility loci (SL) for neurodevelopmental disorders. The goal of this study was to evaluate the pregnancy outcomes in SL cases and to establish a protocol for pregnancy management, follow-up and additional investigations. METHODS: 57 cases were evaluated: 34 with and 23 without ultrasound anomalies at referral...
December 8, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27931048/neurodevelopment-and-health-related-quality-of-life-in-infants-born-with-gastroschisis-a-6-year-retrospective-french-study
#14
Barthelemy Tosello, Meriem Zahed, Floriane Guimond, Karine Baumstarck, Alice Faure, Fabrice Michel, Olivier Claris, Jerome Massardier, Catherine Gire, Thierry Merrot
Introduction Quantify quality of life (QoL) outcomes in gastroschisis children is little assessed. The primary objective was to describe the long-term outcome of newborns with gastroschisis treated in three tertiary care hospitals of France in terms of neurodevelopment and QoL. Materials and Methods The study reported was a cross-sectional, descriptive multicentric retrospective study assessing the outcome of newborns with gastroschisis, born between January 1, 2009, and December 31, 2014, treated at two large and French level III neonatal intensive care units...
December 8, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27930696/risk-factors-for-incidence-of-cardiovascular-diseases-and-all-cause-mortality-in-a-middle-eastern-population-over-a-decade-follow-up-tehran-lipid-and-glucose-study
#15
Mahsa Sardarinia, Samaneh Akbarpour, Mojtaba Lotfaliany, Farideh Bagherzadeh-Khiabani, Mohammadreza Bozorgmanesh, Farhad Sheikholeslami, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: To examine the association between potentially modifiable risk factors with cardiovascular disease (CVD) and all-cause mortality and to quantify their population attributable fractions (PAFs) among a sample of Tehran residents. METHODS: Overall, 8108 participants (3686 men) aged≥30 years, were investigated. To examine the association between risk factors and outcomes, multivariate sex-adjusted Cox proportional hazard regression analysis were conducted, using age as time-scale in two models including general/central adiposity: 1)adjusted for different independent variables including smoking, education, family history of CVD and sex for both outcomes and additionally adjusted for prevalent CVD for all-cause mortality 2)further adjusted for obesity mediators (hypertension, diabetes, lipid profile and chronic kidney disease)...
2016: PloS One
https://www.readbyqxmd.com/read/27929671/development-and-initial-psychometrics-for-a-therapist-competence-instrument-for-cbt-for-youth-anxiety
#16
Bryce D McLeod, Michael A Southam-Gerow, Adriana Rodríguez, Alexis M Quinoy, Cassidy C Arnold, Philip C Kendall, John R Weisz
Therapist competence is an important component of treatment integrity. This article reports on the development and initial psychometric assessment of the Cognitive-Behavioral Treatment for Anxiety in Youth Competence Scale (CBAY-C), an observational instrument designed to capture therapist limited-domain competence (i.e., competence in the delivery of core interventions and delivery methods found in a specific psychosocial treatment program) in the delivery of the core practice elements in individual cognitive-behavioral treatment (ICBT) for youth anxiety...
December 8, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27929661/an-evaluation-of-parent-child-interaction-therapy-with-and-without-motivational-enhancement-to-reduce-attrition
#17
Haley J Webb, Rae Thomas, Leanne McGregor, Elbina Avdagic, Melanie J Zimmer-Gembeck
Although many interventions for child externalizing behavior report promising outcomes for families, high attrition prior to program completion remains a problem. Many programs report dropout rates of 50% or higher. In this trial we sought to reduce attrition and improve outcomes by augmenting a well-known evidence-based intervention, Parent-Child Interaction Therapy (PCIT), with a 3-session individual motivational enhancement component. Participants were 192 Australian caregivers (91.7% female; Mage = 34...
December 8, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27929318/family-involvement-and-parent-teacher-relationships-for-students-with-autism-spectrum-disorders
#18
S Andrew Garbacz, Laura Lee McIntyre, Rachel T Santiago
Family educational involvement and parent-teacher relationships are important for supporting student outcomes and have unique implications for families of children with autism spectrum disorder (ASD). However, little research has examined child and family characteristics among families of children with ASD as predictors of family involvement and parent-teacher relationships. The present study examined child and family variables that may affect family involvement and parent-teacher relationships for families of children with ASD...
December 2016: School Psychology Quarterly
https://www.readbyqxmd.com/read/27929303/correction-to-campos-melady-et-al-2016
#19
(no author information available yet)
Reports an error in "The Effect of Therapists' Adherence and Competence in Delivering the Adolescent Community Reinforcement Approach on Client Outcomes" by Marita Campos-Melady, Jane Ellen Smith, Robert J. Meyers, Susan H. Godley and Mark D. Godley (Psychology of Addictive Behaviors, Advanced Online Publication, Oct 13, 2016, np). In the original article, the disclosed interest for Mark D. Godley in the author note is misrepresented. The accurate representation is that the organization employing Mark D. Godley, Chestnut Health Systems, receives fees for A-CRA training...
December 8, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27929227/intimate-partner-violence
#20
Daniel Dicola, Elizabeth Spaar
Intimate partner violence (IPV) is a prevalent worldwide health problem, affecting women more commonly than men. IPV is underreported and underrecognized by health care professionals. Even when IPV is recognized, it remains an underaddressed issue. In addition to physical injury and death, IPV causes significant physical and psychiatric health problems commonly treated by family physicians. The U.S. Preventive Services Task Force recommends screening all female patients of childbearing age for IPV. There are several brief screening tools that have been proven effective at detecting IPV and that can be used in the office setting...
October 15, 2016: American Family Physician
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