keyword
MENU ▼
Read by QxMD icon Read
search

dir

keyword
https://www.readbyqxmd.com/read/28644615/fluoromodules-consisting-of-a-promiscuous-rna-aptamer-and-red-or-blue-fluorogenic-cyanine-dyes-selection-characterization-and-bioimaging
#1
Xiaohong Tan, Tudor P Constantin, Kelly L Sloane, Alan S Waggoner, Marcel P Bruchez, Bruce A Armitage
An RNA aptamer selected for binding to the fluorogenic cyanine dye, dimethylindole red (DIR), also binds and activates another cyanine, oxazole thiazole blue (OTB), giving two well-resolved emission colors. The aptamer binds to each dye with submicromolar KD values, and the resulting fluoromodules exhibit fluorescence quantum yields ranging from 0.17 to 0.51 and excellent photostability. The aptamer was fused to a second aptamer previously selected for binding to the epidermal growth factor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on mammalian cells...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28625473/effect-of-dir-uncertainty-on-prostate-passive-scattering-proton-therapy-dose-accumulation
#2
Yoshitomo Abe, Noriyuki Kadoya, Kazuhiro Arai, Yoshiki Takayama, Takahiro Kato, Kanako Kimura, Takashi Ono, Tatsuya Nakamura, Hitoshi Wada, Yasuhiro Kikuchi, Keiichi Jingu
Deformable image registration (DIR) is important in dose accumulation. Currently, the impact of DIR-algorithm-associated uncertainties in proton therapy is unclear. Here, we quantify the effect of DIR uncertainties on prostate passive-scattering proton therapy (PSPT) dose accumulation. Ten patients with an intermediate risk for prostate cancer formerly treated by PSPT (PTV D95=78GyE) were studied. Dose distributions from all verification CT images (five images per patient) were warped and accumulated in the planning CT geometries with DIR...
June 15, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28619289/validation-of-a-method-for-dose-of-the-day-calculation-in-head-neck-tomotherapy-by-using-planning-ct-to-mvct-deformable-image-registration
#3
M Branchini, C Fiorino, I Dell'Oca, M L Belli, L Perna, N Di Muzio, R Calandrino, S Broggi
PURPOSE: The aim of this study was to test the feasibility and dosimetric accuracy of a method that employs planning CT-to-MVCT deformable image registration (DIR) for calculation of the daily dose for head and neck (HN) patients treated with Helical Tomotherapy (HT). METHODS: For each patient, the planning kVCT (CTplan) was deformably registered to the MVCT acquired at the 15th therapy session (MV15) with a B-Spline Free Form algorithm using Mattes mutual information (open-source software 3D Slicer), resulting in a deformed CT (CTdef)...
June 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28607651/assessment-of-the-diagnostic-accuracy-of-double-inversion-recovery-sequence-compared-with-flair-and-t2w_tse-in-detection-of-cerebral-multiple-sclerosis-lesions
#4
Zahra Abidi, Fariborz Faeghi, Zahra Mardanshahi, Hasan Mortazavi
BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. MRI has an important role in early diagnosis of MS within diagnostic criteria. AIM: To determine the diagnostic value of the double inversion recovery (DIR) sequence in detection of brain MS lesions. METHODS: In this cross-sectional study, 55 patients were admitted to the MRI department in Vali-E-Asr Hospital in Qaemshahr, Iran, from May 2016 to February 2016...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28604969/-genetic-study-of-a-fetus-with-9p-direct-duplication-deletion-syndrome
#5
Shanshan Shi, Shaobin Lin, Xiangying Lou, Weijing Li
OBJECTIVE: To use next generation sequencing (NGS) to identify unknown abnormality of chromosome 9 in a fetus and explore its mechanism. METHODS: A pregnant woman with abnormal fetal ultrasound finding underwent amniocentesis for G-banded chromosomal analysis. Karyotyping was also performed on peripheral blood samples derived from its parents. Fetal blood sample was obtained for NGS testing to identify abnormality unrecognized by karyotyping. RESULTS: Analysis of amniocytes has revealed a 46,XX,der(9)(?::p21 to qter) karyotype, while both parents had a normal karyotype...
June 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28595311/evaluation-of-rectum-and-bladder-dose-accumulation-from-external-beam-radiotherapy-and-brachytherapy-for-cervical-cancer-using-two-different-deformable-image-registration-techniques
#6
Noriyuki Kadoya, YuYa Miyasaka, Takaya Yamamoto, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Noriyoshi Takahashi, Masaki Kubozono, Rei Umezawa, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We evaluated dose-volume histogram (DVH) parameters based on deformable image registration (DIR) between brachytherapy (BT) and external beam radiotherapy (EBRT) that included a center-shielded (CS) plan. Eleven cervical cancer patients were treated with BT, and their pelvic and CS EBRT were studied. Planning CT images for EBRT and BT (except for the first BT, used as the reference image) were deformed with DIR to reference image. We used two DIR parameter settings: intensity-based and hybrid. Mean Dice similarity coefficients (DSCs) comparing EBRT with the reference for the uterus, rectum and bladder were 0...
June 8, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28592843/pluronic-f127-and-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-tpgs-mixed-micelles-for-targeting-drug-delivery-across-the-blood-brain-barrier
#7
Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB). Rhodamine 123 (Rho123) and DiR loaded mixed micelles, composed of Pluronic F127 and TPGS with proportion of 4:1 (FT), were prepared by thin-film hydration, and β-galactosidase (β-Gal) loaded FT mixed micelles were prepared by self-assembly. The brain-targeted capability of FT mixed micelles were evaluated both in vitro and in vivo...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588000/effect-of-maternal-obesity-on-fetal-growth-and-the-expression-of-placental-fatty-acid-transporters
#8
Kui Ye, Li Li, Dan Zhang, Yi Li, Hai Qing Wang, Han Lin Lai, Chuan Lai Hu
OBJECTIVE: To explore the effects of maternal high-fat diet induced obesity on fetal growth and the expression of placental nutrient transporters. METHODS: Maternal obesity was established in rats by 8 weeks of pre-pregnancy high-fat (HF) diet feeding, while rats in the control group were fed with normal (CON) diet. Diet induced obesity (DIO) rats and diet induced obesity resistant (DIR) rats were selected according to body weight gain over this period. After copulation, the CON rats were divided into two groups: switched to HF diet (CON-HF group) or maintained on the CON diet (CON-CON group)...
June 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28540184/detection-of-intramyocardially-injected-dir-labeled-mesenchymal-stem-cells-by-optical-and-optoacoustic-tomography
#9
Markus T Berninger, Pouyan Mohajerani, Moritz Wildgruber, Nicolas Beziere, Melanie A Kimm, Xiaopeng Ma, Bernhard Haller, Megan J Fleming, Stephan Vogt, Martina Anton, Andreas B Imhoff, Vasilis Ntziachristos, Reinhard Meier, Tobias D Henning
The distribution of intramyocardially injected rabbit MSCs, labeled with the near-infrared dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbo-cyanine-iodide (DiR) using hybrid Fluorescence Molecular Tomography-X-ray Computed Tomography (FMT-XCT) and Multispectral Optoacoustic Tomography (MSOT) imaging technologies, was investigated. Viability and induction of apoptosis of DiR labeled MSCs were assessed by XTT- and Caspase-3/-7-testing in vitro. 2 × 10(6), 2 × 10(5) and 2 × 10(4) MSCs labeled with 5 and 10 μg DiR/ml were injected into fresh frozen rabbit hearts...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28535910/dose-warping-performance-in-deformable-image-registration-in-lung
#10
Shunsuke Moriya, Hidenobu Tachibana, Nozomi Kitamura, Amit Sawant, Masanori Sato
PURPOSE: It is unclear that spatial accuracy can reflect the impact of deformed dose distribution. In this study, we used dosimetric parameters to compare an in-house deformable image registration (DIR) system using NiftyReg, with two commercially available systems, MIM Maestro (MIM) and Velocity AI (Velocity). METHODS: For 19 non-small-cell lung cancer patients, the peak inspiration (0%)-4DCT images were deformed to the peak expiration (50%)-4DCT images using each of the three DIR systems, which included computation of the deformation vector fields (DVF)...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28529253/relationship-between-blurring-and-refocus-flip-angle-in-3d-double-inversion-recovery-mri
#11
Tomoyuki Wada, Norio Hayashi, Shunichi Motegi, Hiroyuki Nagase, Kouichi Ujita, Akio Ogura, Toshihiro Ogura, Takehiro Shimada, Yoshito Tsushima
It is important to optimize imaging parameters in 3D-double inversion recovery (DIR) magnetic resonance imaging (MRI) for detecting cortical micro lesions. However, inadequate parameters markedly raise blurring in 3DDIR MRI. The purpose of this study was to evaluate the relationship between the blurring and refocus flip angle (RFA) in 3D-DIR MRI. White matter attenuated inversion recovery (WAIR) images as a test sample were obtained by 1.5T MRI with various RFA settings (30°, 40°, 60°, 100°, 140°, 180°, and variable refocus flip angle (VRFA))...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28506023/optimization-method-of-mri-scan-parameters-of-a-double-inversion-recovery-sequence-using-a-t1-map-and-a-developed-analysis-algorithm
#12
Norio Hayashi, Kazuma Yarita, Kozue Sakata, Shunichi Motegi, Hiroyuki Nagase, Kouichi Ujita, Akio Ogura, Toshihiro Ogura, Takehiro Shimada, Yoshito Tsushima
BACKGROUND: Optimizing scan parameters for double inversion recovery (DIR) sequences remains difficult. OBJECTIVE: To evaluate a new method for optimizing DIR sequence scan parameters using T1 mapping and a newly developed analysis algorithm. METHODS: Twelve healthy volunteers underwent T1 mapping and DIR magnetic resonance imaging. The following steps were used for image optimization including: 1) measurement of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) T1 values to create a T1 map; 2) calculation of optimized scan parameters by using a developed analysis algorithm; 3) performance assessment of DIR magnetic resonance imaging by using the calculated optimized imaging parameters...
May 6, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28494089/evaluation-of-the-tumor-registration-error-in-biopsy-procedures-performed-under-real-time-pet-ct-guidance
#13
Louise M Fanchon, Adytia Apte, C Ross Schmidtlein, Ellen Yorke, Yu-Chi Hu, Snjezana Dogan, Mathieu Hatt, Dimitris Visvikis, John L Humm, Stephen B Solomon, Assen S Kirov
PURPOSE: The purpose of this study is to quantify tumor displacement during real-time PET/CT guided biopsy and to investigate correlations between tumor displacement and false-negative results. METHODS: 19 patients who underwent real-time (18) F-FDG PET-guided biopsy and were found positive for malignancy were included in this study under IRB approval. PET/CT images were acquired for all patients within minute prior biopsy to visualize the FDG-avid region and plan the needle insertion...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28490254/validating-dose-uncertainty-estimates-produced-by-autodirect-an-automated-program-to-evaluate-deformable-image-registration-accuracy
#14
Hojin Kim, Josephine Chen, Justin Phillips, Jason Pukala, Sue S Yom, Neil Kirby
Deformable image registration is a powerful tool for mapping information, such as radiation therapy dose calculations, from one computed tomography image to another. However, deformable image registration is susceptible to mapping errors. Recently, an automated deformable image registration evaluation of confidence tool was proposed to predict voxel-specific deformable image registration dose mapping errors on a patient-by-patient basis. The purpose of this work is to conduct an extensive analysis of automated deformable image registration evaluation of confidence tool to show its effectiveness in estimating dose mapping errors...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28477378/evaluating-the-accuracy-of-4d-ct-ventilation-imaging-first-comparison-with-technegas-spect-ventilation
#15
Fiona Hegi-Johnson, Paul Keall, Jeff Barber, Chuong Bui, John Kipritidis
INTRODUCTION: Computed tomography ventilation imaging (CTVI) is a highly accessible functional lung imaging modality that can unlock the potential for functional avoidance in lung cancer radiation therapy. Previous attempts to validate CTVI against clinical ventilation single-photon emission computed tomography (V-SPECT) have been hindered by radioaerosol clumping artifacts. This work builds on those studies by performing the first comparison of CTVI with (99m) Tc-carbon ('Technegas'), a clinical V-SPECT modality featuring smaller radioaerosol particles with less clumping...
May 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28477340/a-neural-network-approach-for-fast-automated-quantification-of-dir-performance
#16
John Neylon, Yugang Min, Daniel A Low, Anand Santhanam
PURPOSE: A critical step in adaptive radiotherapy (ART) workflow is deformably registering the simulation CT with the daily or weekly volumetric imaging. Quantifying the deformable image registration accuracy under these circumstances is a complex task due to the lack of known ground-truth landmark correspondences between the source data and target data. Generating landmarks manually (using experts) is time-consuming, and limited by image quality and observer variability. While image similarity metrics (ISM) may be used as an alternative approach to quantify the registration error, there is a need to characterize the ISM values by developing a non-linear cost function and translate them to physical distance measures in order to enable fast, quantitative comparison of registration performance...
May 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28475493/adaptive-radiotherapy-for-nsclc-patients-utilizing-the-principle-of-energy-conservation-to-evaluate-dose-mapping-operations
#17
Hualiang Zhong, Indrin J Chetty
Tumor regression during the course of fractionated radiotherapy confounds the ability to accurately estimate the total dose delivered to tumor targets. Here we present a new criterion to improve the accuracy of image intensity-based dose mapping operations for adaptive radiotherapy for patients with non-small cell lung cancer (NSCLC). Six NSCLC patients were retrospectively investigated in this study. An image intensity-based B-spline registration algorithm was used for deformable image registration (DIR) of weekly CBCT images to a reference image...
May 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28472925/registration-error-of-the-liver-ct-using-deformable-image-registration-of-mim-maestro-and-velocity-ai
#18
Nobuyoshi Fukumitsu, Kazunori Nitta, Toshiyuki Terunuma, Toshiyuki Okumura, Haruko Numajiri, Yoshiko Oshiro, Kayoko Ohnishi, Masashi Mizumoto, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
BACKGROUND: Understanding the irradiated area and dose correctly is important for the reirradiation of organs that deform after irradiation, such as the liver. We investigated the spatial registration error using the deformable image registration (DIR) software products MIM Maestro (MIM) and Velocity AI (Velocity). METHODS: Image registration of pretreatment computed tomography (CT) and posttreatment CT was performed in 24 patients with liver tumors. All the patients received proton beam therapy, and the follow-up period was 4-14 (median: 10) months...
May 4, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28472349/dirigent-proteins-in-plants-modulating-cell-wall-metabolism-during-abiotic-and-biotic-stress-exposure
#19
Candelas Paniagua, Anna Bilkova, Phil Jackson, Siarhei Dabravolski, Willi Riber, Vojtech Didi, Josef Houser, Nora Gigli-Bisceglia, Michaela Wimmerova, Eva Budinska, Thorsten Hamann, Jan Hejatko
Dirigent (DIR) proteins were found to mediate regio- and stereoselectivity of bimolecular phenoxy radical coupling during lignan biosynthesis. Here we summarize the current knowledge of the importance of DIR proteins in lignan and lignin biosynthesis and highlight their possible importance in plant development. We focus on the still rather enigmatic Arabidopsis DIR gene family, discussing the few members with known functional importance. We comment on recent discoveries describing the detailed structure of two DIR proteins with implications in the mechanism of DIR-mediated catalysis...
May 3, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28426189/issues-confronting-rural-pharmacies-after-a-decade-of-medicare-part-d
#20
Fred Ullrich, Abiodun Salako, Keith Mueller
Purpose. The RUPRI Center for Rural Health Policy Analysis has been monitoring the status of rural independent pharmacies since the implementation of Medicare Part D in 2005. After a decade of Part D, we reassess in this brief the issues that concern rural pharmacies and may ultimately challenge their provision of services. This reassessment is based on survey responses from rural pharmacists. Key Findings: (1) Rural pharmacists indicated that two challenges--direct and indirect remuneration (DIR) fees, and delayed maximum allowable cost (MAC) adjustment--ranked highest on scales of both magnitude and immediacy...
April 2017: Rural Policy Brief
keyword
keyword
80121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"