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https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#1
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28195164/ph-sensitive-micelles-for-the-intracellular-co-delivery-of-curcumin-and-pluronic-l61-unimers-for-synergistic-reversal-effect-of-multidrug-resistance
#2
Wei Hong, Hong Shi, Mingxi Qiao, Zehui Zhang, Wenting Yang, Lingying Dong, Fucheng Xie, Chunpeng Zhao, Li Kang
Pluronic L61 unimers, which are biomacromolecular modulators, and curcumin, a small-molecule modulator, were co-formulated into pH-sensitive micelles to reveal the full synergistic potential of combination drug treatments to reverse multidrug resistance (MDR). Compared to monotherapy, combined therapy significantly improved the cytotoxicity, cellular uptake and apoptotic effects of doxorubicin (DOX) against MCF-7/ADR cells. In mechanistic studies, both L61 and curcumin enhanced the cytotoxic effect by acting on mitochondrial signalling pathways...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183306/third-generation-drug-eluting-stent-des-with-biodegradable-polymer-in-diabetic-patients-5%C3%A2-years-follow-up
#3
Marcus Wiemer, Sinisa Stoikovic, Alexander Samol, Zisis Dimitriadis, Juan M Ruiz-Nodar, Ralf Birkemeyer, Jacques Monsegu, Gérard Finet, David Hildick-Smith, Damras Tresukosol, Enrique Garcia Novo, Jacques J Koolen, Emanuele Barbato, Gian Battista Danzi
OBJECTIVE: To report the long-term safety and efficacy data of a third generation drug eluting stent (DES) with biodegradable polymer in the complex patient population of diabetes mellitus after a follow-up period of 5 years. BACKGROUND: After percutaneous coronary intervention patients with diabetes mellitus are under higher risk of death, restenosis and stent thrombosis (ST) compared to non-diabetic patients. METHODS: In 126 centers worldwide 3067 patients were enrolled in the NOBORI 2 registry, 888 patients suffered from diabetes mellitus (DM), 213 of them (14%) being insulin dependent (IDDM)...
February 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28168934/a-comparative-evaluation-of-3-different-free-form-deformable-image-registration-and-contour-propagation-methods-for-head-and-neck-mri
#4
Sara Broggi, Elisa Scalco, Maria Luisa Belli, Gerlinde Logghe, Dirk Verellen, Stefano Moriconi, Anna Chiara, Anna Palmisano, Renata Mellone, Claudio Fiorino, Giovanna Rizzo
PURPOSE: To validate and compare the deformable image registration and parotid contour propagation process for head and neck magnetic resonance imaging in patients treated with radiotherapy using 3 different approaches-the commercial MIM, the open-source Elastix software, and an optimized version of it. MATERIALS AND METHODS: Twelve patients with head and neck cancer previously treated with radiotherapy were considered. Deformable image registration and parotid contour propagation were evaluated by considering the magnetic resonance images acquired before and after the end of the treatment...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28161434/deformable-image-registration-for-cervical-cancer-brachytherapy-dose-accumulation-organ-at-risk-dose-volume-histogram-parameter-reproducibility-and-anatomic-position-stability
#5
E Flower, V Do, J Sykes, C Dempsey, L Holloway, K Summerhayes, D I Thwaites
PURPOSE: The purpose of this study was to determine the effect of deformable image registration (DIR) on cumulative organ at risk dose-volume histogram (DVH) parameter summation for more than three brachytherapy fractions. The reproducibility of different methods of DIR was tested. DIR was then used to assess the stability of the anatomic position of the DVH parameters within the bladder and rectum. METHODS AND MATERIALS: DIR was completed for 39 consecutive cervical cancer brachytherapy patients' planning CTs...
February 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28158642/evaluation-of-the-performance-of-deformable-image-registration-between-planning-ct-and-cbct-images-for-the-pelvic-region-comparison-between-hybrid-and-intensity-based-dir
#6
Yoshiki Takayama, Noriyuki Kadoya, Takaya Yamamoto, Kengo Ito, Mizuki Chiba, Kousei Fujiwara, Yuya Miyasaka, Suguru Dobashi, Kiyokazu Sato, Ken Takeda, Keiichi Jingu
No abstract text is available yet for this article.
February 2, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28113548/visualization-of-deformable-image-registration-quality-using-local-image-dissimilarity
#7
Matthias Schlachter, Tobias Fechter, Miro Jurisic, Tanja Schimek-Jasch, Oliver Oehlke, Sonja Adebahr, Wolfgang Birkfellner, Ursula Nestle, Katja Buhler
Deformable image registration (DIR) has the potential to improve modern radiotherapy in many aspects, including volume definition, treatment planning and image-guided adaptive radiotherapy. Studies have shown its possible clinical benefits. However, measuring DIR accuracy is difficult without known ground truth, but necessary before integration in the radiotherapy workflow. Visual assessment is an important step towards clinical acceptance. We propose a visualization framework which supports the exploration and the assessment of DIR accuracy...
April 29, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28109567/evaluation-of-residual-abdominal-tumour-motion-in-carbon-ion-gated-treatments-through-respiratory-motion-modelling
#8
Giorgia Meschini, Matteo Seregni, Andrea Pella, Mario Ciocca, Piero Fossati, Francesca Valvo, Marco Riboldi, Guido Baroni
At the Italian National Centre for Oncologic Hadrontherapy (CNAO) patients with upper-abdominal tumours are being treated with carbon ion therapy, adopting the respiratory gating technique in combination with layered rescanning and abdominal compression to mitigate organ motion. Since online imaging of the irradiated volume is not feasible, this study proposes a modelling approach for the estimation of residual motion of the target within the gating window. The model extracts a priori respiratory motion information from the planning 4DCT using deformable image registration (DIR), then combines such information with the external surrogate signal recorded during dose delivery...
January 18, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28098510/dt-mri-microstructural-cortical-lesion-damage-does-not-explain-cognitive-impairment-in-ms
#9
Paolo Preziosa, Elisabetta Pagani, Maria E Morelli, Massimiliano Copetti, Vittorio Martinelli, Fiammetta Pirro, Andrea Falini, Giancarlo Comi, Massimo Filippi, Maria A Rocca
OBJECTIVE: We combined double inversion recovery (DIR) and diffusion tensor (DT) magnetic resonance imaging (MRI) to quantify the severity of cortical lesion (CL) microstructural tissue abnormalities in a large cohort of relapse-onset multiple sclerosis (MS) patients and its contribution to cognitive dysfunction. METHODS: DIR, DT, dual-echo, and three-dimensional (3D) T1-weighted scans were acquired from 149 MS patients and 40 controls. Cognitively impaired (CI) patients had ⩾2 abnormal neuropsychological tests...
January 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28095856/baff-index-and-cxcl13-levels-in-the-cerebrospinal-fluid-associate-respectively-with-intrathecal-igg-synthesis-and-cortical-atrophy-in-multiple-sclerosis-at-clinical-onset
#10
M Puthenparampil, L Federle, S Miante, A Zito, E Toffanin, S Ruggero, M Ermani, S Pravato, D Poggiali, P Perini, F Rinaldi, P Gallo
BACKGROUND: B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and immunoglobulin production within the central nervous system (CNS) in MS. METHODS: Paired cerebrospinal fluid (CSF) and serum specimens from 40 clinically isolated syndrome suggestive of MS or early-onset relapsing-remitting MS patients (CIS/eRRMS) and 17 healthy controls (HC) were analyzed for the intrathecal synthesis of IgG (quantitative formulae and IgG oligoclonal bands, IgGOB), CXCL13, BAFF, and IL-21...
January 17, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28081014/canny-edge-based-deformable-image-registration
#11
Vasant Kearney, Yihui Huang, Weihua Mao, Baohong Yuan, Liping Tang
This work focuses on developing a 2D Canny edge-based deformable image registration (Canny DIR) algorithm to register in vivo white light images taken at various time points. This method uses a sparse interpolation deformation algorithm to sparsely register regions of the image with strong edge information. A stability criterion is enforced which removes regions of edges that do not deform in a smooth uniform manner. Using a synthetic mouse surface ground truth model, the accuracy of the Canny DIR algorithm was evaluated under axial rotation in the presence of deformation...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28072693/comparative-evaluation-of-target-volumes-defined-by-deformable-and-rigid-registration-of-diagnostic-pet-ct-to-planning-ct-in-primary-esophageal-cancer
#12
COMPARATIVE STUDY
Yanluan Guo, Jianbin Li, Peng Zhang, Qian Shao, Min Xu, Yankang Li
BACKGROUND: To evaluate the geometrical differences of target volumes propagated by deformable image registration (DIR) and rigid image registration (RIR) to assist target volume delineation between diagnostic Positron emission tomography/computed tomography (PET/CT) and planning CT for primary esophageal cancer (EC). METHODS: Twenty-five patients with EC sequentially underwent a diagnostic F-fluorodeoxyglucose (F-FDG) PET/CT scan and planning CT simulation. Only 19 patients with maximum standardized uptake value (SUVmax) ≥ 2...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28072395/evaluation-of-adaptive-treatment-planning-for-patients-with-non-small-cell-lung-cancer
#13
Hualiang Zhong, Salim Siddiqui, Benjamin Movsas, Indrin Chetty
The purpose of this study was to develop metrics to evaluate uncertainties in deformable dose accumulation (DDA) for patients with non-small cell lung cancer (NSCLC). Initial treatment plans (primary) and cone-beam CT (CBCT) images were retrospectively processed for seven NSCLC patients, who showed significant tumor regression during the course of treatment. Each plan was developed with IMRT for 2 Gy��33 fractions. A B-spline-based DIR algorithm was used to register weekly CBCT images to a reference image acquired at fraction 21 and the resultant displacement vector fields (DVFs) were then modified using a finite element method (FEM)...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28069552/longitudinal-monitoring-of-skin-accumulation-of-nanocarriers-and-biologicals-with-fiber-optic-near-infrared-fluorescence-spectroscopy-fonirs
#14
James I Griffin, Michael J Benchimol, Dmitri Simberg
Systemically injected drug delivery systems distribute into various organs and tissues, including liver, spleen and kidneys. Recent reports pointed out a significant accumulation of systemically injected nanoparticles in the skin. Skin constitutes the largest organ in the body with important immune functions, and accumulation of drug delivery systems could have significant implications for skin toxicity in living subjects. Fiber optic-based near-infrared spectroscopy (FONIRS) setup was developed and tested for measuring of NIR (760nm excitation) emission spectra in the skin...
January 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28058533/the-numerical-stability-of-transformation-based-ct-ventilation
#15
Edward Castillo, Richard Castillo, Yevgeniy Vinogradskiy, Thomas Guerrero
: Computed tomography (CT)-derived ventilation imaging utilizes deformable image registration (DIR) to recover respiratory-induced tissue volume changes from inhale/exhale 4DCT phases. While current strategies for validating CT ventilation rely on analyzing its correlation with existing functional imaging modalities, the numerical stability of the CT ventilation calculation has not been characterized. PURPOSE: The purpose of this study is to examine how small changes in the DIR displacement field can affect the calculation of transformation-based CT ventilation...
January 5, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28048860/su-f-p-54-guidelines-to-check-image-registration-qa-of-a-clinical-deformation-registration-software-a-single-institution-preliminary-study
#16
G Gill, S Souri, A Rea, Y Chen, J Antone, X Qian, A Riegel, P Taylor, M Marrero, F Diaz, Y Cao, A Jamshidi, S Barley, V Sorell, G Karangelis, T Button, E Klein
PURPOSE: The objective of this study is to verify and analyze the accuracy of a clinical deformable image registration (DIR) software. METHODS: To test clinical DIR software qualitatively and quantitatively, we focused on lung radiotherapy and analyzed a single (Lung) patient CT scan. Artificial anatomical changes were applied to account for daily variations during the course of treatment including the planning target volume (PTV) and organs at risk (OAR). The primary CT (pCT) and the structure set (pST) was deformed with commercial tool (ImSimQA-Oncology Systems Limited) and after artificial deformation (dCT and dST) sent to another commercial tool (VelocityAI-Varian Medical Systems)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048843/su-f-j-134-evaluation-of-deformation-field-accuracy-using-regional-rigid-registrations-with-variable-size
#17
E Ahunbay, X Li
PURPOSE: How to quickly assess the uncertainty in the Deformation Field (DF) generated from Deformable Image Registration (DIR) over the imaged anatomy is a major issue. Here we introduce a method to determine the DF uncertainty using local rigid registrations of varying box size. METHODS: A series of 6-degree rigid registrations are performed with a cubic ROI centered on the voxel of the interest. The size of the registration box is varied from a large value, e...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048834/th-ef-bra-03-assessment-of-data-driven-respiratory-motion-compensation-methods-for-4d-cbct-image-registration-and-reconstruction-using-clinical-datasets
#18
M J Riblett, E Weiss, G E Christensen, G D Hugo
PURPOSE: To evaluate the performance of a 4D-CBCT registration and reconstruction method that corrects for respiratory motion and enhances image quality under clinically relevant conditions. METHODS: Building on previous work, which tested feasibility of a motion-compensation workflow using image datasets superior to clinical acquisitions, this study assesses workflow performance under clinical conditions in terms of image quality improvement. Evaluated workflows utilized a combination of groupwise deformable image registration (DIR) and image reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048798/su-f-j-88-comparison-of-two-deformable-image-registration-algorithms-for-ct-to-ct-contour-propagation
#19
A Gopal, H Xu, S Chen
PURPOSE: To compare the contour propagation accuracy of two deformable image registration (DIR) algorithms in the Raystation treatment planning system - the "Hybrid" algorithm based on image intensities and anatomical information; and the "Biomechanical" algorithm based on linear anatomical elasticity and finite element modeling. METHODS: Both DIR algorithms were used for CT-to-CT deformation for 20 lung radiation therapy patients that underwent treatment plan revisions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048776/su-f-j-77-variations-in-the-displacement-vector-fields-calculated-by-different-deformable-image-registration-algorithms-used-in-helical-axial-and-cone-beam-ct-images-of-a-mobile
#20
I Ali, J Jaskowiak, N Alsbou, S Ahmad
PURPOSE: To investigate quantitatively the displacement-vector-fields (DVF) obtained from different deformable image registration algorithms (DIR) in helical (HCT), axial (ACT) and cone-beam CT (CBCT) to register CT images of a mobile phantom and its correlation with motion amplitudes and frequencies. METHODS: HCT, ACT and CBCT are used to image a mobile phantom which includes three targets with different sizes that are manufactured from water-equivalent material and embedded in low density foam...
June 2016: Medical Physics
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