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https://www.readbyqxmd.com/read/29333123/evaluation-of-deformable-image-registration-dir-methods-for-dose-accumulation-in-nasopharyngeal-cancer-patients-during-radiotherapy
#1
Wannapha Nobnop, Imjai Chitapanarux, Hudsaleark Neamin, Somsak Wanwilairat, Vicharn Lorvidhaya, Taweap Sanghangthum
Introduction: Deformable image registration (DIR) is used to modify structures according to anatomical changes for observing the dosimetric effect. In this study, megavoltage computed tomography (MVCT) images were used to generate cumulative doses for nasopharyngeal cancer (NPC) patients by various DIR methods. The performance of the multiple DIR methods was analysed, and the impact of dose accumulation was assessed. Patients and methods: The study consisted of five NPC patients treated with a helical tomotherapy unit...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29323552/using-the-american-college-of-radiology-dose-index-registry-to-evaluate-practice-patterns-and-radiation-dose-estimates-of-pediatric-body-ct
#2
Benjamin Wildman-Tobriner, Keith J Strauss, Mythreyi Bhargavan-Chatfield, Nadja Kadom, Peter Vock, Kimberly E Applegate, Donald P Frush
OBJECTIVE: Imaging registries afford opportunities to study large, heterogeneous populations. The purpose of this study was to examine the American College of Radiology CT Dose Index Registry (DIR) for dose-related demographics and metrics of common pediatric body CT examinations. MATERIALS AND METHODS: Single-phase CT examinations of the abdomen and pelvis and chest submitted to the DIR over a 5-year period (July 2011-June 2016) were evaluated (head CT frequency was also collected)...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29317344/redox-responsive-micelles-from-disulfide-bond-bridged-hyaluronic-acid-tocopherol-succinate-for-the-treatment-of-melanoma
#3
Junping Xia, Yunai Du, Liping Huang, Birendra Chaurasiya, Jiaheng Tu, Thomas J Webster, Chunmeng Sun
Nanotechnology-based chemotherapy is efficient in cancer treatment due to the targeted delivery of small molecules via nano-carriers, which are usually regarded as "inert". However, nano-materials are more preferred as carriers since many cause synergistic anti-tumor effects along with the drug cargo. In this study, a "bioactive" tocopherol succinate (TOS) was grafted to hyaluronic acid (HA) via of disulfide bonds to obtain HA-ss-TOS conjugates which can assemble into nano-micelles but dissociate when exposed to reducing environments in vitro and in vivo...
January 6, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29306379/variation-assessment-of-deformable-registration-in-stereotactic-radiosurgery
#4
C-S Chang, R Shih, J-M Hwang, K-S Chuang
INTRODUCTION: The regular functions of CT-MRI registration include delineation of targets and organs-at-risk (OARs) in radiosurgery planning. The question of whether deformable image registration (DIR) could be applied to stereotactic radiosurgery (SRS) in its place remains a subject of debate. METHODS: This study collected data regarding 16 patients who had undergone single-fraction SRS treatment. All lesions were located close to the brainstem. CT and MRI two image sets were registered by both rigid image registration (RIR) and DIR algorithms...
February 2018: Radiography
https://www.readbyqxmd.com/read/29303317/neutral-d%C3%A2-kk-decays-as-discovery-channels-for-charm-cp-violation
#5
Ulrich Nierste, Stefan Schacht
We point out that the CP asymmetries in the decays D^{0}→K_{S}K^{*0} and D^{0}→K_{S}K[over ¯]^{*0} are potential discovery channels for charm CP violation in the standard model. We stress that no flavor tagging is necessary, the untagged CP asymmetry a_{CP}^{dir}(D[over (-)]→K_{S}K^{*0}) is essentially equal to the tagged one, so that the untagged measurement comes with a significant statistical gain. Depending on the relevant strong phase, |a_{CP}^{dir,untag}| can be as large as 0.003. The CP asymmetry is dominantly generated by exchange diagrams and does not require nonvanishing penguin amplitudes...
December 22, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29299917/near-infrared-cyanine-loaded-liposome-like-nanocapsules-of-camptothecin-floxuridine-conjugate-for-enhanced-chemophotothermal-combination-cancer-therapy
#6
Chuang Gao, Xiaolong Liang, Shanyan Mo, Nisi Zhang, Desheng Sun, Zhifei Dai
A dual-in-dual synergistic strategy was proposed based on the self-assembly of combinatorial nanocapsules (NCs) from Janus camptothecin-floxuridine (CF) conjugate and near infrared absorber of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) by introducing PEGylated phospholipid of DSPE-PEG2000 to help NCs escape the rapid clearance from the bloodstream. Due to the use of amphiphilic CF and DiR themselves to form liposome-like nanocapsules, the obtained CF-DiR NCs owned significantly high loading content, stable co-delivery drug combinations, no premature release and excellent photothermal conversion efficiency...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29299117/a-new-bioluminescent-reporter-system-to-study-the-biodistribution-of-systematically-injected-tumor-derived-bioluminescent-extracellular-vesicles-in-mice
#7
Prakash Gangadaran, Xiu Juan Li, Ho Won Lee, Ji Min Oh, Senthilkumar Kalimuthu, Ramya Lakshmi Rajendran, Seung Hyun Son, Se Hwan Baek, Thoudam Debraj Singh, Liya Zhu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
In vivo biodistribution and fate of extracellular vesicles (EVs) are still largely unknown and require reliable in vivo tracking techniques. In this study, in vivo bioluminescence imaging (BLI) using Renilla luciferase (Rluc) was developed and applied to monitoring of EVs derived from thyroid cancer (CAL-62 cells) and breast cancer (MDA-MB-231) in nude mice after intravenous administration and was compared with a dye-based labeling method for EV derived from CAL-62 cells. The EVs were successfully labeled with Rluc and visualized by BLI in mice...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297939/technical-note-the-impact-of-deformable-image-registration-methods-on-dose-warping
#8
An Qin, Jian Liang, Xiao Han, Nicolette O'Connell, Di Yan
PURPOSE: To investigate the clinical-relevant discrepancy between doses warped by pure-image based deformable image registration (IM-DIR) and by biomechanical-model based DIR (BM-DIR) on intensity homogeneous organs. METHODS AND MATERIALS: Ten patients (5Head&Neck, 5Prostate) were included. A research DIR tool (ADMRIE_v1.12) was utilized for IM-DIR. After IM-DIR, BM-DIR was carried out for organs (parotids, bladder, and rectum) which often encompass sharp dose gradient...
January 3, 2018: Medical Physics
https://www.readbyqxmd.com/read/29297699/on-the-search-for-retrotransposons-alternative-protocols-to-obtain-sequences-to-learn-profile-hidden-markov-models
#9
Carlos N Fischer, Victor De A Campos, Victor H Barella
Profile hidden Markov models (pHMMs) have been used to search for transposable elements (TEs) in genomes. For the learning of pHMMs aimed to search for TEs of the retrotransposon class, the conventional protocol is to use the whole internal nucleotide portions of these elements as representative sequences. To further explore the potential of pHMMs in such a search, we propose five alternative ways to obtain the sets of representative sequences of TEs other than the conventional protocol. In this study, we are interested in Bel-PAO, Copia, Gypsy, and DIRS superfamilies from the retrotransposon class...
January 3, 2018: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29290405/ct-ventilation-imaging-derived-from-breath-hold-ct-exhibits-good-regional-accuracy-with-galligas-pet
#10
Enid M Eslick, John Kipritidis, Denis Gradinscak, Mark J Stevens, Dale L Bailey, Benjamin Harris, Jeremy T Booth, Paul J Keall
BACKGROUND AND PURPOSE: CT ventilation imaging (CTVI) derived from four dimensional CT (4DCT) has shown only moderate spatial accuracy in humans due to 4DCT image artefacts. Here we assess the accuracy of an improved CTVI using high quality exhale/inhale breath-hold CT (BHCT). MATERIALS AND METHODS: Eighteen lung cancer patients underwent exhale/inhale BHCT, 4DCT and Galligas PET ventilation scans in a single imaging session. For each BHCT and 4DCT scan, we performed deformable image registration (DIR) between the inhale and exhale phase images to quantify ventilation using three published metrics: (i) breathing induced lung density change, CTVIDIR-HU (ii) breathing induced volume change CTVIDIR-Jac and (iii) the regional air-tissue product, CTVIHU Spatial accuracy was reported as the voxel-wise Spearman correlation r between CTVI and Galligas PET...
December 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29285813/resveratrol-attenuates-reproductive-alterations-in-type-1-diabetes-induced-rats
#11
Joana Noguères Simas, Talita Biude Mendes, Camila Cicconi Paccola, Vanessa Vendramini, Sandra Maria Miraglia
The progression of diabetes mellitus leads to several complications including overproduction of reactive oxygen species and reproductive alterations. As resveratrol (RES) is a powerful anti-oxidant and an anti-apoptotic compound, we hypothesized that side effects of type-1 diabetes (DM1) on male reproduction could be reduced by the RES treatment. Eighty-four prepubertal male rats were distributed into seven groups: sham-control (SC), RES-treated (R), resveratrol-vehicle-treated (RV), diabetic (D), diabetic-insulin-treated (DI), diabetic-RES-treated (DR), diabetic-insulin and RES-treated (DIR)...
December 29, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29276253/direct-and-indirect-remuneration-fees-the-controversy-continues
#12
Michael Gabay
The Centers for Medicare and Medicaid Services (CMS) initially created direct and indirect remuneration (DIR) fees with the enactment of Medicare Part D in order to track rebates and other price adjustments made to pharmacy benefit managers (PBMs). PBMs have expanded the use of these fees to "claw back" money from pharmacies on already dispensed medications. Community and specialty pharmacies claim these fees are not transparent, hurt patients and taxpayers, and negatively impact their fiscal bottom line, while PBMs assert that these fees actually reduce premiums for patients...
December 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29251777/an-adaptive-motion-regularization-technique-to-support-sliding-motion-in-deformable-image-registration
#13
Yabo Fu, Shi Liu, H Harold Li, Hua Li, Deshan Yang
PURPOSE: Isotropic smoothing has been conventionally used to regularize deformation vector fields (DVFs) in deformable image registration (DIR). However, the isotropic smoothing method enforces global smoothness and therefore cannot accurately model the complex tissue deformation, such as sliding motion at organ boundaries. To accurately model and estimate sliding tissue motion, an adaptive direction-dependent DVF regularization technique was developed in this study. METHODS: A DVF is computed and updated iteratively by minimizing the intensity differences between the images...
December 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/29249335/an-automated-dose-tracking-system-for-adaptive-radiation-therapy
#14
Chang Liu, Jinkoo Kim, Akila Kumarasiri, Essa Mayyas, Stephen L Brown, Ning Wen, Farzan Siddiqui, Indrin J Chetty
BACKGROUND AND OBJECTIVE: The implementation of adaptive radiation therapy (ART) into routine clinical practice is technically challenging and requires significant resources to perform and validate each process step. The objective of this report is to identify the key components of ART, to illustrate how a specific automated procedure improves efficiency, and to facilitate the routine clinical application of ART. METHODS: Data was used from patient images, exported from a clinical database and converted to an intermediate format for point-wise dose tracking and accumulation...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29247685/comparison-among-different-revealers-in-the-study-of-accelerated-blood-clearance-phenomenon
#15
Kaifan Liang, Lirong Wang, Yuqing Su, Mengyang Liu, Rui Feng, Yanzhi Song, Yihui Deng
The markers are the "revealers" of accelerated blood clearance (ABC) phenomenon. PEGylated nanocarriers labeled with various markers have been used to explore the mechanism of ABC. However, different markers were labeled on different nanocarriers, and the influence of different markers on ABC phenomenon is questionable. In this study, tocopheryl nicotinate (TN), N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, triethylammonium salt (NBD-DPPE), and 1,1'-dioctadecyl-3,3,3',3'-tetra-methylindotricarbocyanine iodide (DiR) were selected as markers...
December 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29238005/the-advantage-of-synthetic-mri-for-the-visualization-of-anterior-temporal-pole-lesions-on-double-inversion-recovery-dir-phase-sensitive-inversion-recovery-psir-and-myelin-images-in-a-patient-with-cadasil
#16
Lauren Wallaert, Akifumi Hagiwara, Christina Andica, Masaaki Hori, Kazuo Yamashiro, Saori Koshino, Tomoko Maekawa, Koji Kamagata, Shigeki Aoki
No abstract text is available yet for this article.
December 12, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29225433/supervoxels-for-graph-cuts-based-deformable-image-registration-using-guided-image-filtering
#17
Adam Szmul, Bartłomiej W Papież, Andre Hallack, Vicente Grau, Julia A Schnabel
In this work we propose to combine a supervoxel-based image representation with the concept of graph cuts as an efficient optimization technique for 3D deformable image registration. Due to the pixels/voxels-wise graph construction, the use of graph cuts in this context has been mainly limited to 2D applications. However, our work overcomes some of the previous limitations by posing the problem on a graph created by adjacent supervoxels, where the number of nodes in the graph is reduced from the number of voxels to the number of supervoxels...
October 4, 2017: Journal of Electronic Imaging
https://www.readbyqxmd.com/read/29218838/intended-and-unintended-targeting-of-polymeric-nanocarriers-the-case-of-modified-poly-glycerol-adipate-nanoparticles
#18
Verena M Weiss, Henrike Lucas, Thomas Mueller, Petr Chytil, Tomáš Etrych, Toufik Naolou, Jörg Kressler, Karsten Mäder
Biodegradable nanoparticles based on stearic acid-modified poly(glycerol adipate) (PGAS) are promising carriers for drug delivery. In order to investigate the impact of the particle interface characteristics on the biological fate, PGAS nanoparticles are covalently and noncovalently coated with N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers. HPMA copolymer-modified PGAS nanoparticles have similar particle sizes, but less negative zeta-potentials. Nanoparticles are double labeled with the fluorescent dyes DiR (noncovalently) and DYOMICS-676 (covalently bound to HPMA copolymer), and their biodistribution is investigated noninvasively by multispectral optical imaging...
December 8, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29198389/cumulative-dose-of-radiation-therapy-of-hepatocellular-carcinoma-patients-and-its-deterministic-relation-to-radiation-induced-liver-disease
#19
Pu Huang, Gang Yu, Daniel S Kapp, Xue-Feng Bian, Chang-Sheng Ma, Hong-Sheng Li, Jin-Hu Chen, Yue-Qiang Liang, Yang Zhang, Shao-Hua Qin, Yao-Qin Xie, Yong Yang, Yong Yin, Lei Xing, Deng-Wang Li
This study aimed to investigate the relationship between dose and radiation-induced liver disease (RILD) in patients with hepatocellular carcinoma (HCC) receiving 3-dimensional conformal radiotherapy (3DCRT). Twenty-three patients with HCC who received conventional fractionated 3DCRT, including 7 who were diagnosed with classic RILD, were enrolled in this retrospective investigation. Cone-beam computed tomography (CBCT) scans were acquired at the time of treatment for each patient. The beams from each patient's treatment plan were applied to each pretreatment CBCT (the modified CBCT or mCBCT) to construct the delivered dose distribution of the day considering inter-treatment anatomy changes...
November 29, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29195561/dose-accumulation-of-multiple-high-dose-rate-prostate-brachytherapy-treatments-in-two-commercially-available-image-registration-systems
#20
Joel Poder, Johnson Yuen, Andrew Howie, Andrej Bece, Joseph Bucci
PURPOSE: The purpose of this study was to assess whether deformable image registration (DIR) is required for dose accumulation of multiple high dose rate prostate brachytherapy (HDRPBT) plans treated with the same catheter pattern on two different CT datasets. METHOD: DIR was applied to 20 HDRPBT patients' planning CT images who received two treatment fractions on sequential days, on two different CT datasets, with the same implant. Quality of DIR in Velocity and MIM image registration systems was assessed by calculating the Dice Similarity Coefficient (DSC) and mean distance to agreement (MDA) for the prostate, urethra and rectum contours...
November 2017: Physica Medica: PM
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