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https://www.readbyqxmd.com/read/28744122/penetration-of-blood-brain-barrier-and-antitumor-activity-and-nerve-repair-in-glioma-by-doxorubicin-loaded-monosialoganglioside-micelles-system
#1
Dan Zou, Wei Wang, Daoxi Lei, Ying Yin, Peng Ren, Jinju Chen, Tieying Yin, Bochu Wang, Guixue Wang, Yazhou Wang
For the treatment of glioma and other central nervous system diseases, one of the biggest challenges is that most therapeutic drugs cannot be delivered to the brain tumor tissue due to the blood-brain barrier (BBB). The goal of this study was to construct a nanodelivery vehicle system with capabilities to overcome the BBB for central nervous system administration. Doxorubicin as a model drug encapsulated in ganglioside GM1 micelles was able to achieve up to 9.33% loading efficiency and 97.05% encapsulation efficiency by orthogonal experimental design...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28725237/a-novel-soybean-dirigent-gene-gmdir22-contributes-to-promotion-of-lignan-biosynthesis-and-enhances-resistance-to-phytophthora-sojae
#2
Ninghui Li, Ming Zhao, Tengfei Liu, Lidong Dong, Qun Cheng, Junjiang Wu, Le Wang, Xi Chen, Chuanzhong Zhang, Wencheng Lu, Pengfei Xu, Shuzhen Zhang
Phytophthora root and stem rot caused by the oomycete pathogen Phytophthora sojae is a destructive disease of soybean worldwide. Plant dirigent proteins (DIR) are proposed to have roles in biosynthesis of either lignan or lignin-like molecules, and are important for defense responses, secondary metabolism, and pathogen resistance. In the present work, a novel DIR gene expressed sequence tag is identified as up-regulated in the highly resistant soybean cultivar 'Suinong 10' inoculated with P. sojae. The full length cDNA is isolated using rapid amplification of cDNA ends, and designated GmDIR22 (GenBank accession no...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712282/deformable-image-registration-in-radiation-therapy
#3
REVIEW
Seungjong Oh, Siyong Kim
The number of imaging data sets has significantly increased during radiation treatment after introducing a diverse range of advanced techniques into the field of radiation oncology. As a consequence, there have been many studies proposing meaningful applications of imaging data set use. These applications commonly require a method to align the data sets at a reference. Deformable image registration (DIR) is a process which satisfies this requirement by locally registering image data sets into a reference image set...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28699001/identification-classification-and-transcriptional-profiles-of-dirigent-domain-containing-proteins-in-sugarcane
#4
Paula Macedo Nobile, Alexandra Bottcher, Juliana L S Mayer, Michael S Brito, Ivan A Dos Anjos, Marcos Guimarães de Andrade Landell, Renato Vicentini, Silvana Creste, Diego Mauricio Riaño-Pachón, Paulo Mazzafera
Dirigent (DIR) proteins, encoded by DIR genes, are referred to as "dirigent" because they direct the outcome of the coupling of the monolignol coniferyl alcohol into (+) or (-) pinoresinol, the first intermediates in the enantiocomplementary pathways for lignan biosynthesis. DIR domain-containing or DIR-like proteins are, thus, termed for not having a clear characterization. A transcriptome- and genome-wide survey of DIR domain-containing proteins in sugarcane was carried out, in addition to phylogenetic, physicochemical and transcriptional analyses...
July 11, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28697558/comparative-analysis-of-cortical-microinfarcts-and-microbleeds-using-3-0-tesla-postmortem-magnetic-resonance-images-and-histopathology
#5
Atsushi Niwa, Yuichiro Ii, Akihiro Shindo, Ko Matsuo, Hidehiro Ishikawa, Akira Taniguchi, Shinichi Takase, Masayuki Maeda, Hajime Sakuma, Hiroyasu Akatsu, Yoshio Hashizume, Hidekazu Tomimoto
Microvascular lesions including cortical microinfarctions (CMIs) and cerebral lobar microbleeds (CMBs) are usually caused by cerebral amyloid angiopathy (CAA) in the elderly and are correlated with cognitive decline. However, their radiological-histopathological coincidence has not been revealed systematically with widely used 3-Tesla (3T) magnetic resonance imaging (MRI). The purpose of the present study is to delineate the histopathological background corresponding to MR images of these lesions. We examined formalin-fixed 10-mm thick coronal brain blocks from 10 CAA patients (five were also diagnosed with Alzheimer's disease, three with dementia with Lewy bodies, and two with CAA only) with dementia and six non CAA patients with neurodegenerative disease...
July 5, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28678163/genome-sequences-of-marine-shrimp-exopalaemon-carinicauda-holthuis-provide-insights-into-genome-size-evolution-of-caridea
#6
Jianbo Yuan, Yi Gao, Xiaojun Zhang, Jiankai Wei, Chengzhang Liu, Fuhua Li, Jianhai Xiang
Crustacea, particularly Decapoda, contains many economically important species, such as shrimps and crabs. Crustaceans exhibit enormous (nearly 500-fold) variability in genome size. However, limited genome resources are available for investigating these species. Exopalaemoncarinicauda Holthuis, an economical caridean shrimp, is a potential ideal experimental animal for research on crustaceans. In this study, we performed low-coverage sequencing and de novo assembly of the E. carinicauda genome. The assembly covers more than 95% of coding regions...
July 5, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28644615/fluoromodules-consisting-of-a-promiscuous-rna-aptamer-and-red-or-blue-fluorogenic-cyanine-dyes-selection-characterization-and-bioimaging
#7
Xiaohong Tan, Tudor P Constantin, Kelly L Sloane, Alan S Waggoner, Marcel P Bruchez, Bruce A Armitage
An RNA aptamer selected for binding to the fluorogenic cyanine dye, dimethylindole red (DIR), also binds and activates another cyanine, oxazole thiazole blue (OTB), giving two well-resolved emission colors. The aptamer binds to each dye with submicromolar KD values, and the resulting fluoromodules exhibit fluorescence quantum yields ranging from 0.17 to 0.51 and excellent photostability. The aptamer was fused to a second aptamer previously selected for binding to the epidermal growth factor receptor (EGFR) to create a bifunctional aptamer that labels cell-surface EGFR on mammalian cells...
June 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28625473/effect-of-dir-uncertainty-on-prostate-passive-scattering-proton-therapy-dose-accumulation
#8
Yoshitomo Abe, Noriyuki Kadoya, Kazuhiro Arai, Yoshiki Takayama, Takahiro Kato, Kanako Kimura, Takashi Ono, Tatsuya Nakamura, Hitoshi Wada, Yasuhiro Kikuchi, Keiichi Jingu
Deformable image registration (DIR) is important in dose accumulation. Currently, the impact of DIR-algorithm-associated uncertainties in proton therapy is unclear. Here, we quantify the effect of DIR uncertainties on prostate passive-scattering proton therapy (PSPT) dose accumulation. Ten patients with an intermediate risk for prostate cancer formerly treated by PSPT (PTV D95=78GyE) were studied. Dose distributions from all verification CT images (five images per patient) were warped and accumulated in the planning CT geometries with DIR...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28619289/validation-of-a-method-for-dose-of-the-day-calculation-in-head-neck-tomotherapy-by-using-planning-ct-to-mvct-deformable-image-registration
#9
M Branchini, C Fiorino, I Dell'Oca, M L Belli, L Perna, N Di Muzio, R Calandrino, S Broggi
PURPOSE: The aim of this study was to test the feasibility and dosimetric accuracy of a method that employs planning CT-to-MVCT deformable image registration (DIR) for calculation of the daily dose for head and neck (HN) patients treated with Helical Tomotherapy (HT). METHODS: For each patient, the planning kVCT (CTplan) was deformably registered to the MVCT acquired at the 15th therapy session (MV15) with a B-Spline Free Form algorithm using Mattes mutual information (open-source software 3D Slicer), resulting in a deformed CT (CTdef)...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28607651/assessment-of-the-diagnostic-accuracy-of-double-inversion-recovery-sequence-compared-with-flair-and-t2w_tse-in-detection-of-cerebral-multiple-sclerosis-lesions
#10
Zahra Abidi, Fariborz Faeghi, Zahra Mardanshahi, Hasan Mortazavi
BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. MRI has an important role in early diagnosis of MS within diagnostic criteria. AIM: To determine the diagnostic value of the double inversion recovery (DIR) sequence in detection of brain MS lesions. METHODS: In this cross-sectional study, 55 patients were admitted to the MRI department in Vali-E-Asr Hospital in Qaemshahr, Iran, from May 2016 to February 2016...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28604969/-genetic-study-of-a-fetus-with-9p-direct-duplication-deletion-syndrome
#11
Shanshan Shi, Shaobin Lin, Xiangying Lou, Weijing Li
OBJECTIVE: To use next generation sequencing (NGS) to identify unknown abnormality of chromosome 9 in a fetus and explore its mechanism. METHODS: A pregnant woman with abnormal fetal ultrasound finding underwent amniocentesis for G-banded chromosomal analysis. Karyotyping was also performed on peripheral blood samples derived from its parents. Fetal blood sample was obtained for NGS testing to identify abnormality unrecognized by karyotyping. RESULTS: Analysis of amniocytes has revealed a 46,XX,der(9)(?::p21 to qter) karyotype, while both parents had a normal karyotype...
June 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28595311/evaluation-of-rectum-and-bladder-dose-accumulation-from-external-beam-radiotherapy-and-brachytherapy-for-cervical-cancer-using-two-different-deformable-image-registration-techniques
#12
Noriyuki Kadoya, YuYa Miyasaka, Takaya Yamamoto, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Yujiro Nakajima, Noriyoshi Takahashi, Masaki Kubozono, Rei Umezawa, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We evaluated dose-volume histogram (DVH) parameters based on deformable image registration (DIR) between brachytherapy (BT) and external beam radiotherapy (EBRT) that included a center-shielded (CS) plan. Eleven cervical cancer patients were treated with BT, and their pelvic and CS EBRT were studied. Planning CT images for EBRT and BT (except for the first BT, used as the reference image) were deformed with DIR to reference image. We used two DIR parameter settings: intensity-based and hybrid. Mean Dice similarity coefficients (DSCs) comparing EBRT with the reference for the uterus, rectum and bladder were 0...
June 8, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28592843/pluronic-f127-and-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-tpgs-mixed-micelles-for-targeting-drug-delivery-across-the-blood-brain-barrier
#13
Xin Meng, Jiansheng Liu, Xiangrong Yu, Jiajia Li, Xiaotong Lu, Teng Shen
A novel polymeric mixed micelle composed of Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) was developed to improve the delivery of fluorescent dyes and protein across the blood brain barrier (BBB). Rhodamine 123 (Rho123) and DiR loaded mixed micelles, composed of Pluronic F127 and TPGS with proportion of 4:1 (FT), were prepared by thin-film hydration, and β-galactosidase (β-Gal) loaded FT mixed micelles were prepared by self-assembly. The brain-targeted capability of FT mixed micelles were evaluated both in vitro and in vivo...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28588000/effect-of-maternal-obesity-on-fetal-growth-and-the-expression-of-placental-fatty-acid-transporters
#14
Kui Ye, Li Li, Dan Zhang, Yi Li, Hai Qing Wang, Han Lin Lai, Chuan Lai Hu
OBJECTIVE: To explore the effects of maternal high-fat diet induced obesity on fetal growth and the expression of placental nutrient transporters. METHODS: Maternal obesity was established in rats by 8 weeks of pre-pregnancy high-fat (HF) diet feeding, while rats in the control group were fed with normal (CON) diet. Diet induced obesity (DIO) rats and diet induced obesity resistant (DIR) rats were selected according to body weight gain over this period. After copulation, the CON rats were divided into two groups: switched to HF diet (CON-HF group) or maintained on the CON diet (CON-CON group)...
June 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28540184/detection-of-intramyocardially-injected-dir-labeled-mesenchymal-stem-cells-by-optical-and-optoacoustic-tomography
#15
Markus T Berninger, Pouyan Mohajerani, Moritz Wildgruber, Nicolas Beziere, Melanie A Kimm, Xiaopeng Ma, Bernhard Haller, Megan J Fleming, Stephan Vogt, Martina Anton, Andreas B Imhoff, Vasilis Ntziachristos, Reinhard Meier, Tobias D Henning
The distribution of intramyocardially injected rabbit MSCs, labeled with the near-infrared dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbo-cyanine-iodide (DiR) using hybrid Fluorescence Molecular Tomography-X-ray Computed Tomography (FMT-XCT) and Multispectral Optoacoustic Tomography (MSOT) imaging technologies, was investigated. Viability and induction of apoptosis of DiR labeled MSCs were assessed by XTT- and Caspase-3/-7-testing in vitro. 2 × 10(6), 2 × 10(5) and 2 × 10(4) MSCs labeled with 5 and 10 μg DiR/ml were injected into fresh frozen rabbit hearts...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28535910/dose-warping-performance-in-deformable-image-registration-in-lung
#16
Shunsuke Moriya, Hidenobu Tachibana, Nozomi Kitamura, Amit Sawant, Masanori Sato
PURPOSE: It is unclear that spatial accuracy can reflect the impact of deformed dose distribution. In this study, we used dosimetric parameters to compare an in-house deformable image registration (DIR) system using NiftyReg, with two commercially available systems, MIM Maestro (MIM) and Velocity AI (Velocity). METHODS: For 19 non-small-cell lung cancer patients, the peak inspiration (0%)-4DCT images were deformed to the peak expiration (50%)-4DCT images using each of the three DIR systems, which included computation of the deformation vector fields (DVF)...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28529253/relationship-between-blurring-and-refocus-flip-angle-in-3d-double-inversion-recovery-mri
#17
Tomoyuki Wada, Norio Hayashi, Shunichi Motegi, Hiroyuki Nagase, Kouichi Ujita, Akio Ogura, Toshihiro Ogura, Takehiro Shimada, Yoshito Tsushima
It is important to optimize imaging parameters in 3D-double inversion recovery (DIR) magnetic resonance imaging (MRI) for detecting cortical micro lesions. However, inadequate parameters markedly raise blurring in 3DDIR MRI. The purpose of this study was to evaluate the relationship between the blurring and refocus flip angle (RFA) in 3D-DIR MRI. White matter attenuated inversion recovery (WAIR) images as a test sample were obtained by 1.5T MRI with various RFA settings (30°, 40°, 60°, 100°, 140°, 180°, and variable refocus flip angle (VRFA))...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28506023/optimization-method-of-mri-scan-parameters-of-a-double-inversion-recovery-sequence-using-a-t1-map-and-a-developed-analysis-algorithm
#18
Norio Hayashi, Kazuma Yarita, Kozue Sakata, Shunichi Motegi, Hiroyuki Nagase, Kouichi Ujita, Akio Ogura, Toshihiro Ogura, Takehiro Shimada, Yoshito Tsushima
BACKGROUND: Optimizing scan parameters for double inversion recovery (DIR) sequences remains difficult. OBJECTIVE: To evaluate a new method for optimizing DIR sequence scan parameters using T1 mapping and a newly developed analysis algorithm. METHODS: Twelve healthy volunteers underwent T1 mapping and DIR magnetic resonance imaging. The following steps were used for image optimization including: 1) measurement of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) T1 values to create a T1 map; 2) calculation of optimized scan parameters by using a developed analysis algorithm; 3) performance assessment of DIR magnetic resonance imaging by using the calculated optimized imaging parameters...
May 6, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28494089/evaluation-of-the-tumor-registration-error-in-biopsy-procedures-performed-under-real-time-pet-ct-guidance
#19
Louise M Fanchon, Adytia Apte, C Ross Schmidtlein, Ellen Yorke, Yu-Chi Hu, Snjezana Dogan, Mathieu Hatt, Dimitris Visvikis, John L Humm, Stephen B Solomon, Assen S Kirov
PURPOSE: The purpose of this study is to quantify tumor displacement during real-time PET/CT guided biopsy and to investigate correlations between tumor displacement and false-negative results. METHODS: 19 patients who underwent real-time (18) F-FDG PET-guided biopsy and were found positive for malignancy were included in this study under IRB approval. PET/CT images were acquired for all patients within minute prior biopsy to visualize the FDG-avid region and plan the needle insertion...
May 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28490254/validating-dose-uncertainty-estimates-produced-by-autodirect-an-automated-program-to-evaluate-deformable-image-registration-accuracy
#20
Hojin Kim, Josephine Chen, Justin Phillips, Jason Pukala, Sue S Yom, Neil Kirby
Deformable image registration is a powerful tool for mapping information, such as radiation therapy dose calculations, from one computed tomography image to another. However, deformable image registration is susceptible to mapping errors. Recently, an automated deformable image registration evaluation of confidence tool was proposed to predict voxel-specific deformable image registration dose mapping errors on a patient-by-patient basis. The purpose of this work is to conduct an extensive analysis of automated deformable image registration evaluation of confidence tool to show its effectiveness in estimating dose mapping errors...
January 1, 2017: Technology in Cancer Research & Treatment
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