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https://www.readbyqxmd.com/read/29903008/immunomodulatory-properties-of-quercetin-3-o-%C3%AE-l-rhamnopyranoside-from-rapanea-melanophloeos-against-influenza-a-virus
#1
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29884169/pregnant-women-s-views-on-how-to-promote-the-use-of-a-decision-aid-for-down-syndrome-prenatal-screening-a-theory-informed-qualitative-study
#2
Titilayo Tatiana Agbadjé, Matthew Menear, Michèle Dugas, Marie-Pierre Gagnon, Samira Abbasgholizadeh Rahimi, Hubert Robitaille, Anik M C Giguère, François Rousseau, Brenda J Wilson, France Légaré
BACKGROUND: For pregnant women and their partners, the decision to undergo Down syndrome prenatal screening is difficult. Patient decision aids (PtDA) can help them make an informed decision. We aimed to identify behaviour change techniques (BCTs) that would be useful in an intervention to promote the use of a PtDA for Down syndrome prenatal screening, and to identify which of these BCTs pregnant women found relevant and acceptable. METHODS: Using the Behaviour Change Wheel and the Theoretical Domains Framework, we conducted a qualitative descriptive study...
June 8, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29873867/pediatric-emergency-research-canada-perc-patient-family-informed-research-priorities-for-pediatric-emergency-medicine
#3
Liza Bialy, Amy C Plint, Stephen B Freedman, David W Johnson, Janet A Curran, Antonia S Stang
BACKGROUND: A growing body of literature supports patient and public involvement in the design, prioritization and dissemination of research and evidence based medicine. The objectives of this project were to engage patients and families in developing a prioritized list of research topics for Pediatric Emergency Medicine (PEM) and to compare results with prior research prioritization initiatives in the ED (emergency department) setting. METHODS: We utilized a systematic process to combine administrative data on frequency of patient presentations to the ED with multiple stakeholder input including an initial stakeholder survey followed by a modified Delphi consensus methodology consisting of two web-based surveys and a face-to-face meeting...
June 6, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29873132/perceived-support-for-medical-cannabis-use-among-approved-medical-cannabis-users-in-canada
#4
Cesar Leos-Toro, Samantha Shiplo, David Hammond
INTRODUCTION AND AIMS: Very little is known about the social experience of medical cannabis use, including the experience of stigma among approved users. The current study examined perceptions of support from physicians, family and friends as well as the prevalence of 'hiding' medicinal cannabis use. DESIGN AND METHODS: An online cross-sectional survey (N = 276) was conducted from 29 April to 8 June 2015. No public sampling frame was available from which to sample approved medical cannabis users (MCU)...
June 5, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29871376/functional-connectivity-alterations-novel-therapy-and-future-implications-in-chronic-pain-management
#5
Stephen L Thorp, Thomas Suchy, Nalini Vadivelu, Erik M Helander, Richard D Urman, Alan D Kaye
BACKGROUND: Chronic pain is a major public health problem resulting in physical and emotional pain for individuals and families, loss of productivity, and an annual cost of billions of dollars. The lack of objective measures available to aid in diagnosis and evaluation of therapies for chronic pain continues to be a challenge for the clinician. OBJECTIVES: Functional magnetic resonance imaging (fMRI) is an imaging technique that can establish regional areas of interest and examine synchronous neuronal activity in functionally related but anatomically distinct regions of the brain, known as functional connectivity...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29852397/organs-and-organisations-situating-ethics-in-organ-donation-after-circulatory-death-in-the-uk
#6
Jessie Cooper
Controlled organ donation after circulatory death (DCD) has recently been revived in the UK, as part of attempts to increase organ donation rates. The re-introduction of DCD has subsequently become the focus of bioethical controversy, since it necessitates intervening in the care of dying patients to obtain quality donor organs. Transplant policy responses to these concerns have generated new legal and ethical guidelines to address uncertainties around DCD, producing claims that the UK has overcome' the ethical challenge of DCD...
May 25, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29793987/advocating-for-life-support-training-of-children-parents-caregivers-school-personnel-and-the-public
#7
James M Callahan, Susan M Fuchs
Out-of-hospital cardiac arrest occurs frequently among people of all ages, including more than 6000 children annually. Pediatric cardiac arrest in the out-of-hospital setting is a stressful event for family, friends, caregivers, classmates, school personnel, and witnesses. Immediate bystander cardiopulmonary resuscitation and the use of automated external defibrillators are associated with improved survival in adults. There is some evidence in which improved survival in children who receive immediate bystander cardiopulmonary resuscitation is shown...
May 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29793985/advocating-for-life-support-training-of-children-parents-caregivers-school-personnel-and-the-public
#8
Susan M Fuchs
Pediatric cardiac arrest in the out-of-hospital setting is a traumatic event for family, friends, caregivers, classmates, and school personnel. Immediate bystander cardiopulmonary resuscitation and the use of automatic external defibrillators have been shown to improve survival in adults. There is some evidence to show improved survival in children who receive immediate bystander cardiopulmonary resuscitation. Pediatricians, in their role as advocates to improve the health of all children, are uniquely positioned to strongly encourage the training of children, parents, caregivers, school personnel, and the lay public in the provision of basic life support, including pediatric basic life support, as well as the appropriate use of automated external defibrillators...
May 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29790923/missed-opportunities-to-prescribe-preexposure-prophylaxis-in-south-carolina-2013-2016
#9
Dawn K Smith, Man-Huei Chang, Wayne A Duffus, Stella Okoye, Sharon Weissman
Introduction: Expanding use of preexposure prophylaxis (PrEP) in ways that address current racial/ethnic disparities is an important HIV prevention goal. We investigated missed opportunities to provide PrEP during healthcare visits occurring prior to HIV infection. Methods: This retrospective cohort study linked South Carolina HIV case surveillance data to 3 statewide healthcare databases. Characteristics of patients, health care visits and providers, sexually transmitted diseases (STD), and other diagnoses, were assessed for medical encounters occurring before an initial HIV diagnosis...
May 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29783246/-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B1-%C3%B1-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B1-%C3%B1-%C3%B1-%C3%B0%C2%BA-%C3%B0-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B1-%C3%B0-%C3%B0-%C3%B0-%C3%B1-%C3%B1-%C3%B1-%C3%B1-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0-%C3%B0
#10
Nataliia O Rynhach, Vasyl M Mykhalchuk, Anatolii H Krut
OBJECTIVE: Introduction: This publication focuses on role of physical activity in promoting and protecting health and well-being. Physical activity is a significant risk factor for noncommunicable diseases. The public's awareness of the risk factors of non-communicable diseases is an important component of their control. The aim: To estimate the level of knowledge of the working age population regarding the essence of a healthy lifestyle and risk factors for non-communicable diseases (with an emphasis on lack of physical activity and its consequences) according to qualitative and quantitative sociological research...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29777097/gwas-on-family-history-of-alzheimer-s-disease
#11
Riccardo E Marioni, Sarah E Harris, Qian Zhang, Allan F McRae, Saskia P Hagenaars, W David Hill, Gail Davies, Craig W Ritchie, Catharine R Gale, John M Starr, Alison M Goate, David J Porteous, Jian Yang, Kathryn L Evans, Ian J Deary, Naomi R Wray, Peter M Visscher
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. We show that self-report of parental history of Alzheimer's dementia for case ascertainment in a genome-wide association study of 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases) is a valid proxy for an AD genetic study. After meta-analysing with published consortium data (n = 74,046 with 25,580 cases across the discovery and replication analyses), three new AD-associated loci (P < 5 × 10-8 ) are identified...
May 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29765565/the-rediscovery-of-the-social-side-of-medicine-philosophy-and-value-of-the-international-classification-of-functioning-disability-and-health-icf
#12
EDITORIAL
Wolfgang Seger
Medicine is at risk of sliding into a sole repair service for the malfunction of organs. But the patients' hope and confidence towards doctors practicing this repair work go far beyond that: after acute medical treatment many patients suffer from chronic impairments due to the natural course of the disease or as a result of medical interventions. Despite resulting handicaps, patients aim at participating in family and social life, retaining a workplace and receiving support to remain a valued member of the family and the community...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764296/-medicine-doesn-t-cure-my-worries-understanding-the-drivers-of-mental-distress-in-older-nepalese-women-living-in-the-uk
#13
Lalita Kumari Sah, Rochelle Ann Burgess, Rajeeb Kumar Sah
The mental health of migrant communities is an important public health concern. A growing body of literature suggests that social and cultural determinants of health significantly contribute to the mental health and wellbeing of older migrants in their host countries. Despite the increasing population of older Nepalese migrants in the UK, there is little research exploring the mental health needs of this community. This article explores older Nepalese women's experiences of drivers of mental distress in London...
May 15, 2018: Global Public Health
https://www.readbyqxmd.com/read/29741734/society-of-behavioral-medicine-sbm-position-statement-sbm-urges-congress-to-preserve-and-extend-funding-for-medicaid-services
#14
Pamela Behrman, Jill Demirci, Betina Yanez, Nisha Beharie, Helena Laroche
In May 2017, the Trump administration proposed steep cuts to Medicaid funding. This proposal was met with bipartisan criticism, as this program provides vital healthcare coverage for vulnerable children, adults, and families, including those living below the federal poverty line. In addition to the proposed funding cuts, federally authorized state restrictions to Medicaid access (e.g., work requirements) have been proposed, putting the Medicaid coverage of scores of enrollees at risk. Overwhelming health costs from inadequate or absent insurance are found to contribute to financial problems, including bankruptcy...
May 8, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29741728/interprofessional-healthcare-teams-in-the-military-a-scoping-literature-review
#15
Lara Varpio, Karlen S Bader, Holly S Meyer, Steven J Durning, Anthony R Artino, Meghan K Hamwey
Introduction: Research into healthcare delivered via interprofessional healthcare teams (IHTs) has uncovered that IHT can improve patient satisfaction, enhance collaborative behaviors, reduce clinical error rates, and streamline management of care delivery. Importantly, these achievements are attained by IHTs that have been trained via interprofessional education (IPE). Research indicates that interprofessional healthcare team training must be contextualized to suit the demands of each care context...
May 8, 2018: Military Medicine
https://www.readbyqxmd.com/read/29736071/assessing-the-extent-of-utilization-of-biopsychosocial-model-in-doctor-patient-interaction-in-public-sector-hospitals-of-a-developing-country
#16
Maha Nadir, Muhammad Hamza, Nadir Mehmood
Background: Biopsychosocial (BPS) model has been a mainstay in the ideal practice of modern medicine. It is attributed to improve patient care, compliance, and satisfaction and to reduce doctor-patient conflict. The study aimed to understand the importance given to BPS model while conducting routine doctor-patient interactions in public sector hospitals of a developing country where health resources are limited. The study was conducted in Rawalpindi, Pakistan. Materials and Methods: The study design is qualitative...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29733372/cnf1-like-deamidase-domains-common-lego-bricks-among-cancer-promoting-immunomodulatory-bacterial-virulence-factors
#17
Mengfei Ho, Amel Mettouchi, Brenda A Wilson, Emmanuel Lemichez
Alterations of the cellular proteome over time due to spontaneous or toxin-mediated enzymatic deamidation of glutamine (Gln) and asparagine (Asn) residues contribute to bacterial infection and might represent a source of aging-related diseases. Here, we put into perspective what is known about the mode of action of the CNF1 toxin from pathogenic E. coli, a paradigm of bacterial deamidases that activate Rho GTPases, to illustrate the importance of determining whether exposure to these factors are risk factors in the etiology age-related diseases, such as cancer...
May 3, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29692920/brain-tumor-biobanking-in-the-precision-medicine-era-building-a-high-quality-resource-for-translational-research-in-neuro-oncology
#18
REVIEW
Quinn T Ostrom, Karen Devine, Jordonna Fulop, Yingli Wolinsky, Peter Liao, Lindsay Stetson, Marta Couce, Andrew E Sloan, Jill S Barnholtz-Sloan
The growth of precision medicine has made access to biobanks with high-quality, well-annotated neuro-oncology biospecimens critical. Developing and maintaining neuro-oncology biobanks is best accomplished through multidisciplinary collaboration between clinicians and researchers. Balancing the needs and leveraging the skills of all stakeholders in this multidisciplinary effort is of utmost importance. Collaboration with a multidisciplinary team of clinicians, health care team members, and institutions, as well as patients and their families, is essential for access to participants in order to obtain informed consent, collect samples under strict standard operating procedures, and accurate and relevant clinical annotation...
December 2017: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29672820/a-review-of-the-toxicity-of-compounds-found-in-herbal-dietary-supplements
#19
Amy Hudson, Elizabeth Lopez, Ahmad J Almalki, Amy L Roe, Angela I Calderón
Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food and Drug Administration has made efforts to prohibit the sale of unsafe herbal dietary supplements, numerous reports have proliferated of adverse events due to these supplements. This literature review investigates bioactive plant compounds commonly used in herbal dietary supplements and their relative toxicities...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29665873/impact-of-paternal-deployment-to-the-conflicts-in-iraq-and-afghanistan-and-paternal-post-traumatic-stress-disorder-on-the-children-of-military-fathers
#20
Nicola T Fear, Ruth V Reed, Sarah Rowe, Howard Burdett, David Pernet, Alyson Mahar, Amy C Iversen, Paul Ramchandani, Alan Stein, Simon Wessely
BACKGROUND: Little is known about the social and emotional well-being of children whose fathers have been deployed to the conflicts in Iraq/Afghanistan or who have post-traumatic stress disorder (PTSD).AimsTo examine the emotional and behavioural well-being of children whose fathers are or have been in the UK armed forces, in particular the effects of paternal deployment to the conflicts in Iraq or Afghanistan and paternal PTSD. METHOD: Fathers who had taken part in a large tri-service cohort and had children aged 3-16 years were asked about the emotional and behavioural well-being of their child(ren) and assessed for symptoms of PTSD via online questionnaires and telephone interview...
June 2018: British Journal of Psychiatry: the Journal of Mental Science
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