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https://www.readbyqxmd.com/read/27922681/cxcr4-promotes-cisplatin-resistance-of-non-small-cell-lung-cancer-in-a-cyp1b1-dependent-manner
#1
Songping Xie, Zhenbo Tu, Jie Xiong, Ganjun Kang, Lina Zhao, Weidong Hu, Haiyan Tan, Kingsley Miyanda Tembo, Qianshan Ding, Xinzhou Deng, Jie Huang, Qiuping Zhang
Chemoresistance is the main cause of treatment failure and high mortality in advanced lung cancer. Cisplatin, an important chemotherapeutic agent for lung cancer, has been observed to show enormously reduced chemotherapeutic efficacy owing to the development of chemoresistance. CXCR4, a stromal-derived-factor-1 specific chemokine receptor, is highly expressed in non-small cell lung cancer (NSCLC) tissues and participates in cancer progression by regulating cell growth, apoptosis or invasion. In this study, we therefore investigated whether CXCR4 plays a role in the cisplatin associated resistance in NSCLC...
December 2, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27922675/overexpression-of-sox18-promotes-prostate-cancer-progression-via-the-regulation-of-tcf1-c-myc-cyclin%C3%A2-d1-and-mmp-7
#2
Huaqi Yin, Zhengzuo Sheng, Xiaowei Zhang, Yiqing Du, Caipeng Qin, Huixin Liu, Yaojun Dun, Qi Wang, Chengyue Jin, Yanhui Zhao, Tao Xu
Sex determining region Y (SRY)-box 18 (SOX18) gene encodes transcription factors that have been recently confirmed to be overexpressed in various human types of cancer and maintain the malignant behavior of cancer cells. However, the role and its potential function in prostate cancer (PCa) has not been demonstrated and the mechanisms of SOX18 involved in tumor progression remain largely unclear. In the present study, the expression of SOX18 was analyzed in 98 PCa and 81 adjacent non-tumor tissues using immunohistochemistry...
December 2, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27922668/dual-inhibition-using-cabozantinib-overcomes-hgf-met-signaling-mediated-resistance-to-pan-vegfr-inhibition-in-orthotopic-and-metastatic-neuroblastoma-tumors
#3
Estelle Daudigeos-Dubus, Ludivine Le Dret, Olivia Bawa, Paule Opolon, Albane Vievard, Irène Villa, Jacques Bosq, Gilles Vassal, Birgit Geoerger
MET is expressed on neuroblastoma cells and may trigger tumor growth, neoangiogenesis and metastasis. MET upregulation further represents an escape mechanism to various anticancer treatments including VEGF signaling inhibitors. We developed in vitro a resistance model to pan-VEGFR inhibition and explored the simultaneous inhibition of VEGFR and MET in neuroblastoma models in vitro and in vivo using cabozantinib, an inhibitor of the tyrosine kinases including VEGFR2, MET, AXL and RET. Resistance in IGR-N91-Luc neuroblastoma cells under continuous in vitro exposure pressure to VEGFR1-3 inhibition using axitinib was associated with HGF and p-ERK overexpression...
December 6, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27922666/antimicrobial-peptide-ll-37-promotes-yb-1-expression-and-the-viability-migration-and-invasion-of-malignant-melanoma-cells
#4
Jinjing Jia, Yan Zheng, Wei Wang, Yongping Shao, Zhengxiao Li, Qiong Wang, Yuan Wang, Huling Yan
The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL‑37 serves a functional role in the development of numerous types of cancer including ovarian, breast, prostate and lung cancer. However, its role in the development of malignant melanoma (MM) remains unclear. To determine the role of LL‑37 and the potential interaction with Y-box binding protein 1 (YB‑1) in MM, RNA interference, western blot, reverse transcription-quantitative polymerase chain reaction, MTT and Transwell assays were performed...
December 2, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27922627/blood-based-and-urinary-prostate-cancer-biomarkers-a-review-and-comparison-of-novel-biomarkers-for-detection-and-treatment-decisions
#5
REVIEW
R J Hendriks, I M van Oort, J A Schalken
BACKGROUND: The diagnosis of prostate cancer (PCa) is currently based on serum PSA testing and/or abnormal digital rectal examination and histopathologic evaluation of prostate biopsies. The main drawback of PSA testing is the lack of specificity for PCa. To improve early detection of PCa more specific biomarkers are needed. In the past few years, many new promising biomarkers have been identified; however, to date, only a few have reached clinical practice. METHODS: In this review, we discuss new blood-based and urinary biomarker models that are promising for usage in PCa detection, follow-up and treatment decision-making...
December 6, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27922483/clinicopathologic-and-prognostic-significance-of-gelatinase-a-in-tunisian-colorectal-cancer-a-case-control-study
#6
Dalel Ben Néjima, Yosr Ben Zarkouna, Pascal Pujol, Amor Gammoudi, Hamouda Boussen, Mohamed Manai
Matrix metalloproteinase-2 (gelatinase A) is a well-known mediator of cancer metastasis, but it is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. In the present study, we investigate whether MMP-2 SNP, MMP-2 mRNAs, and MMP-2 protein are associated with the susceptibility to colorectal cancer in the Tunisian population. The TaqMan allele discrimination assay and DNA sequencing techniques were used for genotyping; MMP-2 expression of each genotype was analyzed by semiquantitative RT-PCR, and MMP-2 protein expression was analyzed by immunohistochemistry staining...
January 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27921232/biological-function-and-mechanism-of-mir-33a-in-prostate-cancer-survival-and-metastasis-via-downregulating-engrailed-2
#7
Q Li, S Lu, X Li, G Hou, L Yan, W Zhang, B Qiao
OBJECTIVE: Recent studies have identified Engrailed-2 (EN-2), a homeobox-containing transcription factor, as a candidate oncogene in prostate cancer (PC). Therapeutic targeting on EN-2, however, is limited because the mechanism underlying EN-2 overexpression in prostatic cancer cells is unknown. This study was to investigate the potential regulatory role of miR-33a on EN-2 expression and explore this signaling axis in ability of prostate cancer survival and metastasis. METHODS: The relative expression of miR-33a and EN-2 in paired prostate cancer tissue and adjacent normal tissue as well as in prostate cancer cell lines, PC3 and DU145, was determined using quantitative real-time PCR or western blot, respectively...
December 5, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27921230/upregulation-of-rock2-in-gastric-cancer-cell-promotes-tumor-cell-proliferation-metastasis-and-invasion
#8
Manhua Li, Jing Ke, Qiuhong Wang, Hongyan Qian, Lei Yang, Xunlei Zhang, Jinzhang Xiao, Haifang Ding, Xiaohang Shan, Qingqing Liu, Ying Xiao, Bojun Bao, Hua Huang
Rho-associated coiled-coil-containing protein kinase 2 (ROCK2) has been known as an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of ROCK2 in gastric cancer (GC) has not been identified. This study showed that ROCK2 expression significantly increased in clinical GC tissues compared with adjacent non-cancer tissues. Immunohistochemistrical analysis showed that high expression of ROCK2 was correlated with tumor grade, tumor-node-metastasis stage, infiltration depth, lymph node invasion and Ki-67, and predicted poor prognosis in 135 gastric cancer specimens...
December 5, 2016: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/27921192/actual-10-year-survivors-after-resection-of-hepatocellular-carcinoma
#9
Jian Zheng, Deborah Kuk, Mithat Gönen, Vinod P Balachandran, T Peter Kingham, Peter J Allen, Michael I D'Angelica, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Resection of hepatocellular carcinoma (HCC) offers a chance of cure, but recurrence is common and survival is often limited. The clinical and pathological characteristics of long-term survivors have not been well studied. METHODS: We retrospectively reviewed 212 patients who underwent partial hepatectomy for HCC with curative intent from 1992 to 2006. Fifty patients who survived beyond 10 years were compared with 109 patients who died of recurrence within 10 years...
December 5, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27920842/utility-of-electrocardiography-ecg-gated-computed-tomography-ct-for-preoperative-evaluations-of-thymic-epithelial-tumors
#10
Yoshiyuki Ozawa, Masaki Hara, Motoo Nakagawa, Yuta Shibamoto
BACKGROUND: Preoperative evaluation of invasion to the adjacent organs is important for the thymic epithelial tumors on CT. The purpose of our study was to evaluate the utility of electrocardiography (ECG)-gated CT for assessing thymic epithelial tumors with regard to the motion artifacts produced and the preoperative diagnostic accuracy of the technique. MATERIAL/METHODS: Forty thymic epithelial tumors (36 thymomas and 4 thymic carcinomas) were examined with ECG-gated contrast-enhanced CT using a dual source scanner...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27920648/synchronous-adenocarcinoma-of-the-colon-and-rectal-carcinoid
#11
Vamshidhar Vootla, Rafeeq Ahmed, Masooma Niazi, Bhavna Balar, Suresh Nayudu
Primary colonic adenocarcinoma and synchronous rectal carcinoids are rare tumors. Whenever a synchronous tumor with a nonmetastatic carcinoid component is encountered, its prognosis is determined by the associate malignancy. The discovery of an asymptomatic gastrointestinal carcinoid during the operative treatment of another malignancy will usually only require resection without additional treatment and will have little effect on the prognosis of the individual. This article reports a synchronous rectal carcinoid in a patient with hepatic flexure adenocarcinoma...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27920639/a-giant-gastrointestinal-stromal-tumor-of-the-stomach-with-extramural-growth
#12
Ryosuke Miyazaki, Seiji Arihiro, Eri Hayashi, Takuya Kitahara, Sayumi Oki, Syunsuke Kamba, Daisuke Ide, Nobuhiko Komoike, Kenichi Satoh, Tomohiro Kato, Masayuki Saruta, Hisao Tajiri, Hiroaki Aoki, Nobuo Omura, Norio Mitsumori, Takehiro Mitsuishi, Haruka Yanagisawa, Hiroyuki Takahashi
A 76-year-old man presented to our hospital with abdominal distention and loss of appetite. The 10% of weight lost relative to this patient in 1 month. Abdominal computed tomography and magnetic resonance imaging revealed a giant mass, with a major axis of 23 cm, containing solid components, not involving the upper abdominal organs. Esophagogastroduodenoscopy showed extramural compression from the middle gastric body to the antrum, as well as a normal mucosal surface. These findings were suggestive of a gastrointestinal stromal tumor attached to the anterior wall of the stomach without metastasis or invasion...
May 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27920521/celastrol-nanomicelles-attenuate-cytokine-secretion-in-macrophages-and-inhibit-macrophage-induced-corneal-neovascularization-in-rats
#13
Zhanrong Li, Jingguo Li, Lei Zhu, Ying Zhang, Junjie Zhang, Lin Yao, Dan Liang, Liya Wang
The aim of the present study was to investigate the inhibitory effects of celastrol-loaded nanomicelles (CNMs) on activated macrophage-induced corneal neovascularization (CNV) in rats and cytokine secretion in macrophages. Using an angiogenesis assay in vitro, we detected the effects of CNMs on human umbilical vein endothelial cell (HUVEC) migration and invasion. In addition, the expression levels of cytokines secreted from hypoxia-induced macrophages were assessed through cytokine array analysis. The expression of hypoxia-inducible factors-1α (HIF-1α), nuclear factor-kappa B p65 (NF-κB p65), phospho-nuclear factor-kappa B p65 (phospho-NF-κB p65), p38 mitogen-activated protein kinase (p38 MAPK), phospho-p38 MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2), and phospho-ERK1/2 was analyzed by western blotting...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27920478/diabetes-mellitus-may-affect-the-long-term-survival-of-hepatitis-b-virus-related-hepatocellular-carcinoma-patients-after-liver-transplantation
#14
Qing Zhang, Yong-Lin Deng, Chang Liu, Li-Hong Huang, Lei Shang, Xin-Guo Chen, Le-Tian Wang, Jin-Zan Du, Ying Wang, Pei-Xiao Wang, Hui Zhang, Zhong-Yang Shen
AIM: To determine whether diabetes mellitus (DM) affects prognosis/recurrence after liver transplantation (LT) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study was conducted between January 2000 and August 2013 on 1631 patients with HBV-related HCC who underwent LT with antiviral prophylaxis. Patient data were obtained from the China Liver Transplant Registry (https://www.cltr.org/). To compare the outcomes and tumor recurrence in the HBV-related HCC patients with or without DM, statistical analyses were conducted using χ(2) tests, Mann-Whitney tests, the Kaplan-Meier method, log-rank tests and multivariate step-wise Cox regression analysis...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27920206/activation-of-d2-dopamine-receptors-in-cd133-ve-cancer-stem-cells-in-non-small-cell-lung-carcinoma-inhibits-proliferation-clonogenic-ability-and-invasiveness-of-these-cells
#15
Soumyabrata Roy, Kai Lu, Mukti Kant Nayak, Avishek Bhuniya, Tithi Ghosh, Suman Kundu, Sarbari Ghosh, Rathindranath Baral, Partha Sarathi Dasgupta, Sujit Basu
Lung carcinoma is the leading cause of cancer-related death worldwide, and among this cancer, non-small cell lung carcinoma (NSCLC) comprises the majority of cases. Furthermore, recurrence and metastasis of NSCLC correlate well with CD133+ve tumor cells, a small population of tumor cells, which has been designated as cancer stem cells (CSC). We here for the first time have demonstrated high expression of D2 dopamine (DA) receptors in CD133+ve adenocarcinoma NSCLC cells. Also, activation of D2 DA receptors in these cells significantly inhibited their proliferation, clonogenic ability and invasiveness by suppressing extracellular-signal-regulated kinases 1/2 (ERK1/2) and AKT, downregulation of octamer-binding transcription factor 4 (Oct-4) expression and matrix metalloproteinase-9 (MMP-9) secretion by these cells...
December 5, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27920099/systematic-regional-lymph-node-dissection-for-upper-tract-urothelial-carcinoma-improves-patient-survival
#16
Hiroshi Furuse, Yuto Matsushita, Takashi Yajima, Taiki Kato, Takahisa Suzuki, Rikiya Matsumoto, Daisuke Motoyama, Takayuki Sugiyama, Atsushi Otsuka, Seiichiro Ozono
OBJECTIVE: Unlike for bladder cancer, the impact of regional lymph node dissection for upper tract urothelial carcinoma is unclear. We explored whether patient survival was influenced by systematic regional lymph node dissection, using resection templates according to the main tumor location, during radical nephroureterectomy for upper tract urothelial carcinoma. METHODS: The systematic regional lymph node dissection group was defined as cases in which the dissection of nodes and surrounding tissues followed the established template, and the non-systematic regional lymph node dissection group as cases undergoing limited or no lymph node dissection...
December 4, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27919990/validation-and-enhancement-of-the-clinicopathological-melanoma-nomogram-via-incorporation-of-a-molecular-marker-in-the-primary-tumor
#17
Samer A Naffouje, Rand Naffouje, Jinsong Chen, George I Salti
BACKGROUND/AIM: To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expression in primary melanoma cells can serve as a predictor of nodal status. Many efforts to identify the nodal spread in cutaneous melanoma using non-invasive means have been recently undertaken...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919988/up-regulation-of-cytoplasmic-cd24-expression-is-associated-with-malignant-transformation-but-favorable-prognosis-of-colorectal-adenocarcinoma
#18
Min-Kyung Yeo, Yong-Moon Lee, In-Ock Seong, Song-Yi Choi, Kwang-Sun Suh, Kyu Sang Song, Choong-Sik Lee, Jin Man Kim, Kyung-Hee Kim
AIM: Cluster of differentiation 24 (CD24) is known to be a putative marker of stem cell and tumor metastasis. This study aimed to verify the clinicopathological value of CD24 expression in colorectal adenocarcinoma (CRAC). MATERIALS AND METHODS: A total of seven whole-tissue sections of malignant polyps including the sequence non-neoplastic colorectal tissue-adenoma-CRAC, 48 adenomas and 161 CRACs arranged as tissue microarray were examined by immunohistochemistry for CD24 protein expression...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919984/clinical-significances-of-preoperative-classification-of-intrahepatic-cholangiocarcinoma-different-characteristics-of-perihilar-vs-peripheral-icc
#19
Yo-Ichi Yamashita, Huanlin Wang, Takeshi Kurihara, Eiji Tsujita, Akihiro Nishie, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Shinichi Aishima, Hideo Baba
BACKGROUND: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). PATIENTS AND METHODS: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. RESULTS: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9)...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919968/overexpression-of-pbk-topk-contributes-to-tumor-development-and-poor-outcome-of-esophageal-squamous-cell-carcinoma
#20
Takuma Ohashi, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Wataru Okajima, Taisuke Imamura, Jun Kiuchi, Keiji Nishibeppu, Toshiyuki Kosuga, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Hitoshi Tsuda, Eigo Otsuji
BACKGROUND: PDZ-binding kinase/T-cell-originated protein kinase (PBK/TOPK) is a serine-threonine kinase and overexpressed in various types of cancer. PBK/TOPK is associated with tumor cell development and progression through suppression of p53 function. In this study, we tested whether PBK acts as a cancer-promoting factor by being overexpressed in esophageal squamous cell carcinoma (ESCC). MATERIALS AND METHODS: We analyzed PBK/TOPK expression in 15 ESCC cell lines, and 54 primary ESCC tumors that were curatively resected between 1994 and 2007...
December 2016: Anticancer Research
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