Fátima Sánchez-Cabo, Valentín Fuster, Juan Carlos Silla-Castro, Gema González, Erika Lorenzo-Vivas, Rebeca Alvarez, Sergio Callejas, Alberto Benguría, Eduardo Gil, Estefanía Núñez, Belén Oliva, José María Mendiguren, Marta Cortes-Canteli, Héctor Bueno, Vicente Andrés, Jose María Ordovás, Leticia Fernández-Friera, Antonio J Quesada, Jose Manuel Garcia, Xavier Rossello, Jesús Vázquez, Ana Dopazo, Antonio Fernández-Ortiz, Borja Ibáñez, Jose Javier Fuster, Enrique Lara-Pezzi
AIMS: Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association. METHODS AND RESULTS: Whole blood methylomics, transcriptomics, and plasma proteomics were obtained for 391 participants of the Progression of Early Subclinical Atherosclerosis study. Epigenetic age was calculated from methylomics data for each participant...
June 20, 2023: European Heart Journal