keyword
https://read.qxmd.com/read/37612015/artificial-intelligence-bob-dylan-and-cardiovascular-scholarship
#21
EDITORIAL
Harold L Dauerman, Justine Varieur Turco, Valentin Fuster
No abstract text is available yet for this article.
August 29, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37587586/challenges-to-science-health-and-education-as-contributors-to-progress-a-call-to-the-young-generation
#22
EDITORIAL
Valentin Fuster, Justine Varieur Turco
No abstract text is available yet for this article.
August 22, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37558377/low-dose-colchicine-for-secondary-prevention-of-coronary-artery-disease-jacc-review-topic-of-the-week
#23
REVIEW
Kyle Nelson, Valentin Fuster, Paul M Ridker
Among statin-treated patients, inflammation assessed by means of high-sensitivity C-reactive protein (hsCRP) is a more powerful determinant of cardiovascular death and all-cause mortality than low-density-lipoprotein cholesterol (LDL-C). Several therapies that target residual inflammatory risk significantly reduce vascular event rates. For coronary artery disease patients already taking guideline-directed medical care, including statins, low-dose colchicine (0.5 mg/d orally) has been shown to safely lower major adverse cardiovascular events by 31% among those with stable atherosclerosis and by 23% after recent myocardial infarction...
August 15, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37531100/school-based-cardiovascular-health-promotion-in-adolescents-a-cluster-randomized-clinical-trial
#24
JOURNAL ARTICLE
Gloria Santos-Beneit, Juan M Fernández-Alvira, Anna Tresserra-Rimbau, Patricia Bodega, Amaya de Cos-Gandoy, Mercedes de Miguel, Sonia L Ramírez-Garza, Emily P Laveriano-Santos, Camila Arancibia-Riveros, Vanesa Carral, Xavier Orrit, Carla Rodríguez, Isabel Carvajal, Domenec Haro, Carles Peyra, Jesús Martínez-Gómez, Antonio Álvarez-Benavides, Ramón Estruch, Rosa M Lamuela-Raventós, Rodrigo Fernández-Jiménez, Valentín Fuster
IMPORTANCE: School-based interventions offer an opportunity for health promotion in adolescence. OBJECTIVE: To assess the effect of 2 multicomponent educational health promotion strategies of differing duration and intensity on adolescents' cardiovascular health (CVH). DESIGN, SETTING, AND PARTICIPANTS: The SI! Program for Secondary Schools is a 4-year cluster randomized clinical intervention trial conducted in 24 secondary schools from Barcelona and Madrid, Spain, from September 7, 2017, to July 31, 2021...
August 2, 2023: JAMA Cardiology
https://read.qxmd.com/read/37503629/sex-differences-in-coronary-atherosclerotic-phenotype-and-healing-pattern-on-optical-coherence-tomography-imaging
#25
JOURNAL ARTICLE
Lena Marie Seegers, Doreen DeFaria Yeh, Taishi Yonetsu, Tomoyo Sugiyama, Yoshiyasu Minami, Tsunenari Soeda, Makoto Araki, Akihiro Nakajima, Haruhito Yuki, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Hang Lee, Iris McNulty, Sunao Nakamura, Tsunekazu Kakuta, Valentin Fuster, Ik-Kyung Jang
BACKGROUND: Layered plaque, a signature of previous plaque disruption, is a known predictor of rapid plaque progression. Layered plaque can be identified in vivo by optical coherence tomography. Studies have reported differences in plaque burden between women and men, but sex differences in the pattern of layered plaque are unknown. METHODS: Preintervention optical coherence tomography images of 533 patients with chronic coronary syndromes were analyzed. Detailed plaque characteristics of layered and nonlayered plaques of the target lesion were compared between men and women...
July 28, 2023: Circulation. Cardiovascular Imaging
https://read.qxmd.com/read/37489131/economic-burden-associated-with-the-treatment-with-a-cardiovascular-polypill-in-secondary-prevention-in-spain-cost-effectiveness-results-of-the-neptuno-study
#26
JOURNAL ARTICLE
Alberto Cordero, Regina Dalmau González-Gallarza, Lluis Masana, Valentín Fuster, Jose Mª Castellano, José Emilio Ruiz Olivar, Ilonka Zsolt, Antoni Sicras-Mainar, Jose Ramón González Juanatey
PURPOSE: The aim of this study was to estimate health-care resources utilization, costs and cost-effectiveness associated with the treatment with CNIC-Polypill as secondary prevention of atherosclerotic cardiovascular disease (ASCVD) compared to other treatments, in clinical practice in Spain. PATIENTS AND METHODS: An observational, retrospective study was performed using medical records (economic results [healthcare perspective], NEPTUNO-study; BIG-PAC-database) of patients who initiated secondary prevention between 2015 and 2018...
2023: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/37452122/heart-transplantation-advances-in-expanding-the-donor-pool-and-xenotransplantation
#27
REVIEW
Stephanie Jou, Sean R Mendez, Jason Feinman, Lindsey R Mitrani, Valentin Fuster, Massimo Mangiola, Nader Moazami, Claudia Gidea
Approximately 65 million adults globally have heart failure, and the prevalence is expected to increase substantially with ageing populations. Despite advances in pharmacological and device therapy of heart failure, long-term morbidity and mortality remain high. Many patients progress to advanced heart failure and develop persistently severe symptoms. Heart transplantation remains the gold-standard therapy to improve the quality of life, functional status and survival of these patients. However, there is a large imbalance between the supply of organs and the demand for heart transplants...
January 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/37354170/interatrial-block-association-with-adverse-cardiovascular-outcomes-in-patients-without-a-history-of-atrial%C3%A2-fibrillation
#28
JOURNAL ARTICLE
Joshua Lampert, David Power, Shreyas Havaldar, Usha Govindarajulu, Iwanari Kawamura, Abhishek Maan, Marc A Miller, Kartikeya Menon, Jacob Koruth, William Whang, Emilia Bagiella, Antoni Bayes-Genis, Daniel Musikantow, Mohit Turagam, Antoni Bayes de Luna, Jonathan Halperin, Srinivas R Dukkipati, Akhil Vaid, Girish Nadkarni, Benjamin Glicksberg, Valentin Fuster, Vivek Y Reddy
BACKGROUND: Interatrial block (IAB) is associated with thromboembolism and atrial arrhythmias. However, prior studies included small patient cohorts so it remains unclear whether IAB predicts adverse outcomes particularly in context of atrial fibrillation (AF). OBJECTIVES: This study sought to determine whether IAB portends increased stroke risk in a large cohort in the presence or absence of AF. METHODS: We performed a 5-center retrospective analysis of 4,837,989 electrocardiograms (ECGs) from 1,228,291 patients...
June 21, 2023: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/37339167/subclinical-atherosclerosis-and-accelerated-epigenetic-age-mediated-by-inflammation-a-multi-omics-study
#29
JOURNAL ARTICLE
Fátima Sánchez-Cabo, Valentín Fuster, Juan Carlos Silla-Castro, Gema González, Erika Lorenzo-Vivas, Rebeca Alvarez, Sergio Callejas, Alberto Benguría, Eduardo Gil, Estefanía Núñez, Belén Oliva, José María Mendiguren, Marta Cortes-Canteli, Héctor Bueno, Vicente Andrés, Jose María Ordovás, Leticia Fernández-Friera, Antonio J Quesada, Jose Manuel Garcia, Xavier Rossello, Jesús Vázquez, Ana Dopazo, Antonio Fernández-Ortiz, Borja Ibáñez, Jose Javier Fuster, Enrique Lara-Pezzi
AIMS: Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association. METHODS AND RESULTS: Whole blood methylomics, transcriptomics, and plasma proteomics were obtained for 391 participants of the Progression of Early Subclinical Atherosclerosis study. Epigenetic age was calculated from methylomics data for each participant...
June 20, 2023: European Heart Journal
https://read.qxmd.com/read/37325406/-jacc-journals-pathway-forward-with%C3%A2-ai-tools-the-future-is-now
#30
EDITORIAL
Valentin Fuster, Biykem Bozkurt, Y Chandrashekhar, Julia Grapsa, Bonnie Ky, Douglas L Mann, David J Moliterno, Kalyanam Shivkumar, Candice K Silversides, Justine Varieur Turco, Jian'an Wang
No abstract text is available yet for this article.
May 2023: JACC. Basic to Translational Science
https://read.qxmd.com/read/37318685/rationale-and-design-of-the-sota-p-cardia-trial-atru-v-sotagliflozin-in-hfpef-patients-without-diabetes
#31
JOURNAL ARTICLE
Maeve Soto Pérez, Jorge Rodríguez-Capitán, Juan Antonio Requena-Ibáñez, Carlos G Santos-Gallego, M Urooj Zafar, Ginés Escolar, Donna Mancini, Sumeet Mitter, David Lam, Johanna P Contreras, Icilma Fergus, Farah Atallah-Lajam, Vivian Abascal, Anu Lala, Pedro Moreno, Noah Moss, Stamatios Lerakis, Javier Sanz, Valentin Fuster, Juan José Badimon
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure (HF). This syndrome is associated with an elevated morbi-mortality, and effective therapies are urgently needed. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are the first pharmacological class that has demonstrated to reduce hospitalization and cardiovascular mortality in large clinical trials in HFpEF. Furthermore, the dual SGLT 1/2 inhibitor sotagliflozin has shown a reduction in cardiovascular outcomes in diabetic HF patients, regardless of ejection fraction Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF) Trial, and prevents the development of HF in patients with diabetes and chronic kidney disease Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED) trial...
June 15, 2023: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/37181383/-jacc-journals-pathway-forward-with%C3%A2-ai-tools-the-future-is-now
#32
EDITORIAL
Valentin Fuster, Biykem Bozkurt, Y Chandrashekhar, Julia Grapsa, Bonnie Ky, Douglas L Mann, David J Moliterno, Kalyanam Shivkumar, Candice K Silversides, Justine Varieur Turco, Jian'an Wang
No abstract text is available yet for this article.
April 2023: JACC Asia
https://read.qxmd.com/read/37178070/advances-in-coronary-computed-tomographic-angiographic-imaging-of%C3%A2-atherosclerosis-for-risk-stratification-and%C3%A2-preventive-care
#33
REVIEW
Solomon Bienstock, Fay Lin, Ron Blankstein, Jonathon Leipsic, Rhanderson Cardoso, Amir Ahmadi, Annetine Gelijns, Krishna Patel, Lauren A Baldassarre, Michael Hadley, Gina LaRocca, Javier Sanz, Jagat Narula, Y S Chandrashekhar, Leslee J Shaw, Valentin Fuster
The diagnostic evaluation of coronary artery disease is undergoing a dramatic transformation with a new focus on atherosclerotic plaque. This review details the evidence needed for effective risk stratification and targeted preventive care based on recent advances in automated measurement of atherosclerosis from coronary computed tomography angiography (CTA). To date, research findings support that automated stenosis measurement is reasonably accurate, but evidence on variability by location, artery size, or image quality is unknown...
March 27, 2023: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/37153478/-jacc-journals-pathway-forward-with%C3%A2-ai-tools-the-future-is-now
#34
EDITORIAL
Valentin Fuster, Biykem Bozkurt, Y Chandrashekhar, Julia Grapsa, Bonnie Ky, Douglas L Mann, David J Moliterno, Kalyanam Shivkumar, Candice K Silversides, Justine Varieur Turco, Jian'an Wang
No abstract text is available yet for this article.
May 3, 2023: JACC. Case reports
https://read.qxmd.com/read/37144104/-jacc-journals-pathway-forward-with%C3%A2-ai-tools-the-future-is-now
#35
EDITORIAL
Valentin Fuster, Biykem Bozkurt, Y Chandrashekhar, Julia Grapsa, Bonnie Ky, Douglas L Mann, David J Moliterno, Kalyanam Shivkumar, Candice K Silversides, Justine Varieur Turco, Jian'an Wang
No abstract text is available yet for this article.
April 2023: JACC CardioOncology
https://read.qxmd.com/read/37140006/sleep-duration-and-its-association-with-adiposity-markers-in-adolescence-a-cross-sectional-and-longitudinal-study
#36
JOURNAL ARTICLE
Jesús Martínez-Gómez, Juan Miguel Fernández-Alvira, Amaya de Cos-Gandoy, Patricia Bodega, Mercedes de Miguel, Anna Tresserra-Rimbau, Emily P Laveriano-Santos, Vanesa Carral, Isabel Carvajal, Ramón Estruch, Rosa María Lamuela-Raventós, Gloria Santos-Beneit, Valentín Fuster, Rodrigo Fernández-Jiménez
BACKGROUND: Large studies linking adolescents' objectively measured sleep duration and adiposity markers are lacking. AIM: To characterize sleep duration and its cross-sectional and longitudinal associations with adiposity markers in adolescence. METHODS: Seven-day accelerometry was performed in a cohort of adolescents enrolled in the SI! Program for Secondary Schools trial in Spain at approximately age 12 (1216 adolescents, 49.6% girls), 14 (1026 adolescents, 51...
May 4, 2023: European Journal of Preventive Cardiology
https://read.qxmd.com/read/37137594/jacc-scientific-statements-a-new-pathway-forged-through%C3%A2-resilience
#37
EDITORIAL
Valentin Fuster, Justine Varieur Turco
No abstract text is available yet for this article.
May 9, 2023: Journal of the American College of Cardiology
https://read.qxmd.com/read/37064511/magnetic-resonance-imaging-reference-values-for-cardiac-morphology-function-and-tissue-composition-in-adolescents
#38
JOURNAL ARTICLE
Carlos Real, Rocío Párraga, Gonzalo Pizarro, Inés García-Lunar, Ernesto González-Calvo, Jesús Martínez-Gómez, Javier Sánchez-González, Patricia Sampedro, Irene Sanmamed, Mercedes De Miguel, Amaya De Cos-Gandoy, Patricia Bodega, Borja Ibanez, Gloria Santos-Beneit, Valentin Fuster, Rodrigo Fernández-Jiménez
BACKGROUND: Cardiovascular magnetic resonance (CMR) is a precise tool for the assessment of cardiac anatomy, function, and tissue composition. However, studies providing CMR reference values in adolescence are scarce. We aim to provide sex-specific CMR reference values for biventricular and atrial dimensions and function and myocardial relaxation times in this population. METHODS: Adolescents aged 15-18 years with no known cardiovascular disease underwent a non-contrast 3-T CMR scan between March 2021 and October 2021...
March 2023: EClinicalMedicine
https://read.qxmd.com/read/37042253/cardioprotective-effect-of-empagliflozin-and-circulating-ketone-bodies-during-acute-myocardial-infarction
#39
JOURNAL ARTICLE
Carlos G Santos-Gallego, Juan Antonio Requena-Ibáñez, Belen Picatoste, Brian Fardman, Kiyotake Ishikawa, Renata Mazurek, Michael Pieper, Samantha Sartori, Jorge Rodriguez-Capitán, Valentin Fuster, Juan J Badimon
BACKGROUND: SGLT2i (sodium-glucose cotransporter-2 inhibitors) improve clinical outcomes in patients with heart failure, but the mechanisms of action are not completely understood. SGLT2i increases circulating levels of ketone bodies, which has been demonstrated to enhance myocardial energetics and induce reverse ventricular remodeling. However, the role of SGLT2i or ketone bodies on myocardial ischemia reperfusion injury remains in the dark. The objective of this study is to investigate the cardioprotective potential of empagliflozin and ketone bodies during acute myocardial infarction (MI)...
April 2023: Circulation. Cardiovascular Imaging
https://read.qxmd.com/read/37042231/valentin-fuster-md-phd-one-of-the-most-widely-acclaimed-physicians-in-cardiovascular-science-and-medicine-talks-to-cardiopulse-about-luck-life-and-legendary-discoveries
#40
JOURNAL ARTICLE
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